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https://www.readbyqxmd.com/read/28734576/predictive-validity-analysis-of-six-reference-equations-for-the-6-minute-walk-test-in-healthy-brazilian-men-a-cross-sectional-study
#1
Alexandher Negreiros, Rosimeire Simprini Padula, Rosane Andrea Bretas Bernardes, Mônica Vasconcelos de Moraes, Raquel Simoni Pires, Luciana Dias Chiavegato
BACKGROUND: The six-minute walk test (6MWT) is an important tool for evaluating functional capacity and exercise tolerance. The reference equations for the 6MWT in healthy subjects were established on the basis of American and European populations, but reference equations have been proposed with different variables for the Brazilian population. OBJECTIVE: To analyze the predictive validity of six reference equations for the six-minute walking distance (6MWD) in healthy adult men...
July 4, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28734350/dried-urine-spots-a-novel-sampling-technique-for-comprehensive-lc-ms-n-drug-screening
#2
Julian A Michely, Markus R Meyer, Hans H Maurer
Dried matrix spot (DMS) technique as alternative sampling strategy, especially dried urine spots (DUS), might be an alternative for drug screening. So far only particular drugs or drug classes were covered in DMS screenings. Therefore, workup of DUS for a broad comprehensive library-based LC-MS(n) screening was developed. It consisted of enzymatic on-spot deconjugation followed by liquid extraction and LC-MS(n) analysis. This workup was compared to established urine precipitation (UP) and validated according to international guidelines for qualitative approaches, using exemplary compounds of several drug classes (antidepressants, benzodiazepines, cardiovascular drugs, neuroleptics, opioids, stimulants, etc...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28733785/fertiliser-management-effects-on-dissolved-inorganic-nitrogen-in-runoff-from-australian-sugarcane-farms
#3
Grant Fraser, Ken Rohde, Mark Silburn
Dissolved inorganic nitrogen (DIN) movement from Australian sugarcane farms is believed to be a major cause of crown-of-thorns starfish outbreaks which have reduced the Great Barrier Reef coral cover by ~21% (1985-2012). We develop a daily model of DIN concentration in runoff based on >200 field monitored runoff events. Runoff DIN concentrations were related to nitrogen fertiliser application rates and decreased after application with time and cumulative rainfall. Runoff after liquid fertiliser applications had higher initial DIN concentrations, though these concentrations diminished more rapidly in comparison to granular fertiliser applications...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28733478/growth-and-morbidity-of-extremely-preterm-infants-after-early-full-enteral-nutrition
#4
Christoph Maas, Axel R Franz, Stefanie von Krogh, Jörg Arand, Christian F Poets
OBJECTIVES: To evaluate feasibility and consequences of accelerated feeding advancement on short-term outcomes in extremely low gestational age neonates (ELGANs) who stayed in our institution for >28 days. METHODS: Retrospective single-centre cohort analysis covering the years 2011-2013. Data are presented as median (IQR). RESULTS: Infants '(n=77) birth weight was 745 (640 to 960) g and gestational age at birth 26.7 (25.1 to 27.4) weeks...
July 21, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28733149/a-comprehensive-pain-assessment-tool-compat-for-chronic-pancreatitis-development-face-validation-and-pilot-evaluation
#5
K Teo, M H Johnson, A M Drewes, J A Windsor
BACKGROUND/OBJECTIVES: Chronic pancreatitis (CP) pain is challenging to treat. Treatment selection is hampered by there being no validated pain assessment tool that accounts for the complexity of CP pain and its underlying mechanisms. This study aims to develop a comprehensive pain assessment tool (COMPAT) specific for CP, evaluate its face validity with experts and patients and test it with a pilot cohort of patients. METHODS: COMPAT was developed from existing pain assessment tools and a literature review...
July 8, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28732223/effect-of-piezoelectric-units-on-the-implantable-cardioverter-and-defibrillator
#6
Gonzalo Gómez Val, Fernando Jara, Baltasar Sánchez, Miguel Roig, Ricard Ferrer, Fernando Duran-Sindreu
PURPOSE: Evidence-based research appears to conflict on the potential risk of electromagnetic interference (EMI) between piezoelectric units (Pzs) and implantable cardioverters and defibrillators (ICDs). The purpose of this study was to observe whether the EMI produced by Pzs is hazardous for ICDs. MATERIALS AND METHODS: A cross-sectional study of 6 Pzs was conducted in vitro for EMI using an ICD system. To simulate the human body's electrical resistance, electrographic recordings were made of the ICD and lead that were immersed in a bath of saline solution...
June 29, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28732098/variability-of-the-pressure-measurements-exerted-by-the-tip-of-laryngoscope-during-laryngeal-sensory-testing-a-clinical-demonstration
#7
Asako Kaneoka, Jessica M Pisegna, Gintas P Krisciunas, Takaharu Nito, Michael P LaValley, Cara E Stepp, Susan E Langmore
Purpose: Clinicians often test laryngeal sensation by touching the laryngeal mucosa with the tip of a flexible laryngoscope. However, the pressure applied to the larynx by using this touch method is unknown, and the expected responses elicited by this method are uncertain. The variability in pressure delivered by clinicians using the touch method was investigated, and the subject responses to the touches were also reported. Methods: A fiberoptic pressure sensor passed through the working channel of a laryngoscope, with its tip positioned at the distal port of the channel...
July 21, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28731979/global-positioning-system-analysis-of-a-high-school-football-scrimmage
#8
Benjamin H Gleason, Matthew L Sams, John T Salley, A Andrew Pustina, Michael H Stone
Gleason, BH, Sams, M, Salley, JT, Pustina, A, and Stone, MH. Global positioning system analysis of a high school football scrimmage. J Strength Cond Res 31(8): 2183-2188, 2017-The purpose of this study was to examine the physical demands of a high school American football scrimmage. Male high school football players (N = 25) participated in a spring scrimmage. Global positioning system data and game film were recorded throughout the entirety of the scrimmage to determine the total distance covered, the distance covered in different velocity bands, the number of accelerations and decelerations performed, and the work-to-rest ratio of the scrimmage...
August 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28731437/computerized-cognitive-screen-cocosc-a-self-administered-computerized-test-for-screening-for-cognitive-impairment-in-community-social-centers
#9
Adrian Wong, Ching-Hang Fong, Vincent Mok, Kam Tat Leung, Raymond Kai-Yu Tong
BACKGROUND: Computerized cognitive tests may serve as a preliminary, low-cost method to identify individuals with suspected cognitive impairment in the community. OBJECTIVE: To develop a self-administered computerized test, namely the "Computerized Cognitive Screen (CoCoSc), Hong Kong version", for screening of individuals with cognitive impairment (CI) in community settings. METHODS: The CoCoSc is a 15-min computerized cognitive screen covering memory, executive functions, orientation, attention and working memory, and prospective memory administered on a touchscreen computer...
July 19, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731000/appropriateness-based-reimbursement-of-elective-invasive-coronary-procedures-in-low-and-middle-income-countries-preliminary-assessment-of-feasibility-in-india
#10
Ganesan Karthikeyan, Umesh Shirodkar, Meeta Rajiv Lochan, Stephen Birch
BACKGROUND: Elective coronary interventional procedures are often overused and sometimes inappropriately used. The incentives for overuse are greater in low- and middle-income countries, where much of healthcare is provided by poorly regulated, fee-for-service systems. Overuse and inappropriate use increase healthcare costs and are potentially harmful to patients. Linking appropriate use of elective procedures to their reimbursement might deter overuse. METHODS: We explored the feasibility of introducing appropriateness criteria as a precondition to settling reimbursement claims in a publicly funded health insurance scheme in Maharashtra, India...
January 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28730936/an-industry-update-what-is-the-latest-news-in-therapeutic-delivery
#11
Iain Simpson
This Industry Update covers the period from 1 through 30 April 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. Biogen expanded its portfolio of developmental drugs targeting neurological diseases by licensing a drug from Bristol-Myers Squibb which is currently under investigation for the treatment of progressive supranuclear palsy. Takeda announced a deal with NuBiyota focused on developing treatments for gastrointestinal disorders, based on the manipulation of microbes living in the gut...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28729755/social-cognition-deficits-current-position-and-future-directions-for-neuropsychological-interventions-in-cerebrovascular-disease
#12
REVIEW
Progress Njomboro
Neuropsychological assessments of cognitive dysfunction in cerebrovascular illness commonly target basic cognitive functions involving aspects of memory, attention, language, praxis, and number processing. Here, I highlight the clinical importance of often-neglected social cognition functions. These functions recruit a widely distributed neural network, making them vulnerable in most cerebrovascular diseases. Sociocognitive deficits underlie most of the problematic social conduct observed in patients and are associated with more negative clinical outcomes (compared to nonsocial cognitive deficits)...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28728489/idarucizumab-for-the-treatment-of-hemorrhage-and-dabigatran-reversal-in-patients-requiring-urgent-surgery-or-procedures
#13
Ovidiu Vornicu, Anne-Sophie Larock, Anne-Sophie Dincq, Jonathan Douxfils, Jean-Michel Dogné, François Mullier, Sarah Lessire
Idarucizumab is a specific antagonist for dabigatran etexilate (DE). The recent market authorization of idarucizumab in Europe and the USA may reassure prescribers of DE, as it can increase the safety of the emergency management of patients taking this anticoagulant. However, idarucizumab use should be limited to specific indications to avoid unnecessary risks to patients and costs to healthcare systems. Areas covered: The authors provide an overview of idarucizumab development and its pharmacokinetic and pharmacodynamic properties...
July 20, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28728124/thin-ferrihydrite-sediment-capping-sequestrates-phosphorus-experiencing-redox-conditions-in-a-shallow-temperate-lacustrine-wetland
#14
Yuanchun Zou, Michael R Grace, Keryn L Roberts, Xiaofei Yu
Synthesized ferrihydrite (Fh) with the dosages of 0.3, 0.6 and 0.9 cm thickness (labeled as Fh, 2Fh and 3Fh respectively, equivalent to 248-774 g/m(2)) were deployed to serve as the reactive capping layer covering the Ornamental Lake sediments, the Royal Botanic Garden of Melbourne. The sediments were exposed to an alternating regime of oxic/anoxic conditions using laboratory reactors for 45 days. Dynamics of dissolved oxygen (DO), pH, filterable reactive phosphorus (FRP), filterable ammonium (NH4(+)), nitrate and nitrite (NOx), total dissolved nitrogen (TDN) and dissolved iron (Fe) of overlying water were examined...
July 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28728110/development-of-a-bioanalytical-test-battery-for-water-quality-monitoring-fingerprinting-identified-micropollutants-and-their-contribution-to-effects-in-surface-water
#15
Peta A Neale, Rolf Altenburger, Selim Aït-Aïssa, François Brion, Wibke Busch, Gisela de Aragão Umbuzeiro, Michael S Denison, David Du Pasquier, Klára Hilscherová, Henner Hollert, Daniel A Morales, Jiří Novák, Rita Schlichting, Thomas-Benjamin Seiler, Helene Serra, Ying Shao, Andrew J Tindall, Knut Erik Tollefsen, Timothy D Williams, Beate I Escher
Surface waters can contain a diverse range of organic pollutants, including pesticides, pharmaceuticals and industrial compounds. While bioassays have been used for water quality monitoring, there is limited knowledge regarding the effects of individual micropollutants and their relationship to the overall mixture effect in water samples. In this study, a battery of in vitro bioassays based on human and fish cell lines and whole organism assays using bacteria, algae, daphnids and fish embryos was assembled for use in water quality monitoring...
July 9, 2017: Water Research
https://www.readbyqxmd.com/read/28727985/comparative-study-and-analytical-verification-of-pcr-methods-for-the-diagnosis-of-congenital-chagas-disease
#16
Carolina Inés Cura, Juan Carlos Ramírez, Marcelo Rodríguez, Constanza Lopez-Albízu, Lucía Irazu, Karenina Scollo, Sergio Sosa-Estani
Congenital infection is currently the first cause of new cases of Chagas disease in Argentina and nonendemic areas worldwide. Its diagnosis is of utmost importance to guarantee curative treatment. To improve such diagnosis, a transfer process of PCR tests to the national laboratory network has been initiated. We performed a comparative study of four PCR assays [two end-point PCR and two duplex real-time quantitative PCR (qPCR) procedures] to detect Trypanosoma cruzi DNA in blood samples. Because satellite DNA and kinetoplastid DNA qPCR methods have the best performance and the use of two different molecular targets for confirmatory purposes has been recommended, these methods selected to perform the transfer process and, in consequence, subjected to an analytical verification protocol based on international guidelines...
July 17, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28727828/spatial-and-temporal-dynamics-of-shifting-cultivation-in-the-middle-amazonas-river-expansion-and-intensification
#17
Catarina Conte Jakovac, Loïc Paul Dutrieux, Latifah Siti, Marielos Peña-Claros, Frans Bongers
Shifting cultivation is the main land-use system transforming landscapes in riverine Amazonia. Increased concentration of the human population around villages and increasing market integration during the last decades may be causing agricultural intensification. Studies have shown that agricultural intensification, i.e. higher number of swidden-fallow cycles and shorter fallow periods, reduces crop productivity of swiddens and the regrowth capacity of fallows, undermining the resilience of the shifting cultivation system as a whole...
2017: PloS One
https://www.readbyqxmd.com/read/28727722/an-attenuated-shigella-mutant-lacking-the-rna-binding-protein-hfq-provides-cross-protection-against-shigella-strains-of-broad-serotype
#18
Jiro Mitobe, Ritam Sinha, Soma Mitra, Dhrubajyoti Nag, Noriko Saito, Ken Shimuta, Nobuo Koizumi, Hemanta Koley
Few live attenuated vaccines protect against multiple serotypes of bacterial pathogen because host serotype-specific immune responses are limited to the serotype present in the vaccine strain. Here, immunization with a mutant of Shigella flexneri 2a protected guinea pigs against subsequent infection by S. dysenteriae type 1 and S. sonnei strains. This deletion mutant lacked the RNA-binding protein Hfq leading to increased expression of the type III secretion system via loss of regulation, resulting in attenuation of cell viability through repression of stress response sigma factors...
July 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28727200/landscape-genetic-analyses-reveal-fine-scale-effects-of-forest-fragmentation-in-an-insular-tropical-bird
#19
Aurélie Khimoun, William Peterman, Cyril Eraud, Bruno Faivre, Nicolas Navarro, Stéphane Garnier
Within the framework of landscape genetics, resistance surface modelling is particularly relevant to explicitly test competing hypotheses about landscape effects on gene flow. To investigate how fragmentation of tropical forest affects population connectivity in a forest-specialist bird species, we optimized resistance surfaces without a priori specification, using least-cost (LCP) or resistance (IBR) distances. We implemented a two-step procedure in order i) to objectively define the landscape thematic resolution (level of detail in classification scheme to describe landscape variables) and spatial extent (area within the landscape boundaries) and then ii) to test the relative role of several landscape features (elevation, roads, land cover) in genetic differentiation in the Plumbeous Warbler (Setophaga plumbea)...
July 20, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28726696/a-novel-freeze-protection-strategy-for-shallow-buried-sewer-pipes-temperature-modelling-and-field-investigation
#20
Youen Pericault, Mikael Risberg, Mattias Vesterlund, Maria Viklander, Annelie Hedström
The burial of sewer and water pipes below the maximum ground frost depth can be very costly and laborious in regions with cold winters. If a freeze protection measure is applied, the utility lines can be installed in a shallower trench to reduce the excavation needs. One freeze protection measure, so called heat tracing, consists of supplying heat along the pipes. In this work, the use of 4th generation district heating as a heat tracing solution was investigated at a pilot site in Kiruna, Sweden. The influence of the system on sewer and water pipe temperatures was studied at a snow-free and snow-covered cross section...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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