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https://www.readbyqxmd.com/read/28339981/transcriptome-analysis-of-comb-and-testis-from-rose-comb-silky-chicken-r1-r1-and-beijing-fatty-wild-type-chicken-r-r
#1
Y Wang, J Li, C Feng, Y Zhao, X Hu, N Li
Rose-comb was one of the chicken comb-variants first used by Bateson and Punnet in 1902 to demonstrate Mendelian inheritance in animals. Rose-comb is a monogenic trait that has been widely described in chickens. It is caused by a large structural rearrangement that leads to mis-expression of transcription factor MNR2 on chromosome 7. Rose-comb has pleiotropic effects in homozygous roosters, which is associated with poor sperm mobility. It was postulated that this is caused by the disruption of the CCDC108 gene located at the distal inversion breakpoint...
March 2, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339176/identification-of-likely-associations-between-cerebral-folate-deficiency-and-complex-genetic-and-metabolic-pathogenesis-of-autism-spectrum-disorders-by-utilization-of-a-pilot-interaction-modeling-approach
#2
Daniel Krsička, Jan Geryk, Markéta Vlčková, Markéta Havlovicová, Milan Macek, Radka Pourová
Recently, cerebral folate deficiency (CFD) was suggested to be involved in the pathogenesis of autism spectrum disorders (ASD). However, the exact role of folate metabolism in the pathogenesis of ASD, identification of underlying pathogenic mechanisms and impaired metabolic pathways remain unexplained. The aim of our study was to develop and test a novel, unbiased, bioinformatics approach in order to identify links between ASD and disturbed cerebral metabolism by focusing on abnormal folate metabolism, which could foster patient stratification and novel therapeutic interventions...
March 24, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28338989/a-simple-stable-carbon-isotope-method-for-investigating-changes-in-the-use-of-recent-versus-old-carbon-in-oak
#3
Danny McCarroll, Matthew Whitney, Giles H F Young, Neil J Loader, Mary H Gagen
Stable carbon isotope ratios from early-wood (EW) and late-wood (LW) are used to test competing models of carbon storage and allocation, providing a cost-effective alternative to measuring and dating non-structural carbohydrates in mature temperate broad-leaf forest trees growing under natural conditions. Annual samples of EW and LW from seven mature oaks (Quercus robur L.) from Scotland, covering AD 1924-2012, were pooled, treated to isolate alpha-cellulose and pyrolysed to measure the carbon isotope ratios...
March 18, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28337955/examining-the-in-vitro-efficacy-of-the-iap-antagonist-birinapant-as-a-single-agent-or-in-combination-with-dacarbazine-to-induce-melanoma-cell-death
#4
Vesna Vetma, Jan Rožanc, Emilie M Charles, Christian T Hellwig, Leonidas G Alexopoulos, Markus Rehm
Antagonists of inhibitor of apoptosis proteins (IAPs), alone or in combination with genotoxic therapeutics, have been shown to efficiently induce cell death in various solid tumours. The IAP antagonist birinapant is currently being tested in phase II clinical trials. We herein aimed to investigate the in vitro anti-tumour efficacy of dacarbazine, both as a single agent and in combination with birinapant, in melanoma cell lines. Covering clinically relevant drug concentration ranges, we conducted a total of 5400 measurements in a panel of 12 human melanoma cell lines representing different stages of disease progression...
March 23, 2017: Oncology Research
https://www.readbyqxmd.com/read/28337433/occupational-stress-and-burnout-among-surgeons-in-fiji
#5
Rajeev Patel, Peter Huggard, Annik van Toledo
AIM: This study examined the levels of occupational stress and burnout among surgeons in Fiji. METHODS: A document set comprising a cover letter; a consent form; a sociodemographic and supplementary information questionnaire; the Maslach Burnout Inventory (MBI); the 12-item General Health Questionnaire (GHQ-12); the Alcohol Use Disorders Identification Test (AUDIT); and the Professional Quality of Life (ProQOL) questionnaires were provided to surgeons from three public divisional hospitals in Fiji...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28337132/habituation-training-improves-locomotor-performance-in-a-forced-running-wheel-system-in-rats
#6
Angel Toval, Raúl Baños, Ernesto De la Cruz, Nicanor Morales-Delgado, Jesús G Pallarés, Abdelmalik Ayad, Kuei Y Tseng, Jose L Ferran
Increasing evidence supports that physical activity promotes mental health; and regular exercise may confer positive effects in neurological disorders. There is growing number of reports that requires the analysis of the impact of physical activity in animal models. Exercise in rodents can be performed under voluntary or forced conditions. The former presents the disadvantage that the volume and intensity of exercise varies from subject to subject. On the other hand, a major challenge of the forced training protocol is the low level of performance typically achieved within a given session...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28336485/low-dose-computed-tomography-for-lung-cancer-screening-clinical-and-coding-considerations
#7
REVIEW
Yiwey Shieh, Martin Bohnenkamp
Lung cancer screening with low-dose computed tomography (LDCT) was shown to reduce lung cancer mortality in the National Lung Screening Trial, a large randomized-controlled trial of high-risk current and former smokers. Despite ongoing uncertainty over the effectiveness of LDCT in the real-world setting, the Centers for Medicare and Medicaid Services (CMS) decided to cover LDCT as a preventive service. As part of its national coverage determination, CMS set forth a series of requirements for reimbursement of LDCT, including a counseling and shared decision-making visit prior to a LDCT being ordered...
March 21, 2017: Chest
https://www.readbyqxmd.com/read/28335799/convergent-and-sequential-synthesis-designs-implications-for-conducting-and-reporting-systematic-reviews-of-qualitative-and-quantitative-evidence
#8
Quan Nha Hong, Pierre Pluye, Mathieu Bujold, Maggy Wassef
BACKGROUND: Systematic reviews of qualitative and quantitative evidence can provide a rich understanding of complex phenomena. This type of review is increasingly popular, has been used to provide a landscape of existing knowledge, and addresses the types of questions not usually covered in reviews relying solely on either quantitative or qualitative evidence. Although several typologies of synthesis designs have been developed, none have been tested on a large sample of reviews. The aim of this review of reviews was to identify and develop a typology of synthesis designs and methods that have been used and to propose strategies for synthesizing qualitative and quantitative evidence...
March 23, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28335545/reference-values-of-14-serum-trace-elements-for-pregnant-chinese-women-a-cross-sectional-study-in-the-china-nutrition-and-health-survey-2010-2012
#9
Xiaobing Liu, Yu Zhang, Jianhua Piao, Deqian Mao, Yajie Li, Weidong Li, Lichen Yang, Xiaoguang Yang
The development of reference values of trace elements is recognized as a fundamental prerequisite for the assessment of trace element nutritional status and health risks. In this study, a total of 1400 pregnant women aged 27.0 ± 4.5 years were randomly selected from the China Nutrition and Health Survey 2010-2012 (CNHS 2010-2012). The concentrations of 14 serum trace elements were determined by high-resolution inductively coupled plasma mass spectrometry. Reference values were calculated covering the central 95% reference intervals (P2...
March 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28335486/implicit-regularization-for-reconstructing-3d-building-rooftop-models-using-airborne-lidar-data
#10
Jaewook Jung, Yoonseok Jwa, Gunho Sohn
With rapid urbanization, highly accurate and semantically rich virtualization of building assets in 3D become more critical for supporting various applications, including urban planning, emergency response and location-based services. Many research efforts have been conducted to automatically reconstruct building models at city-scale from remotely sensed data. However, developing a fully-automated photogrammetric computer vision system enabling the massive generation of highly accurate building models still remains a challenging task...
March 19, 2017: Sensors
https://www.readbyqxmd.com/read/28334653/the-impact-of-transitions-in-insurance-coverage-on-gp-visiting-among-children-in-ireland
#11
Anne Nolan, Richard Layte
The use of direct out-of-pocket payments to finance general practitioner (GP) care by the majority of the population in Ireland is unusual in a European context. Currently, approximately 40 per cent of the population have means-tested access to free GP care, while the remainder must pay the full out-of-pocket cost. In this paper, we use nationally representative data from the Growing up in Ireland (GUI) study to examine the impact of transitions in insurance coverage on GP utilisation among children. GUI surveys two cohorts of nearly 20,000 children (aged 9 months and 9 years at baseline); we use data from the first two waves of each cohort (which covers the period 2007-2012)...
March 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28333472/how-stable-is-the-personal-past-stability-of-most-important-autobiographical-memories-and-life-narratives-across-eight-years-in-a-life-span-sample
#12
Christin Köber, Tilmann Habermas
Considering life stories as the most individual layer of personality (McAdams, 2013) implies that life stories, similar to personality traits, exhibit some stability throughout life. Although stability of personality traits has been extensively investigated, only little is known about the stability of life stories. We therefore tested the influence of age, of the proportion of normative age-graded life events, and of global text coherence on the stability of the most important memories and of brief entire life narratives as 2 representations of the life story...
March 23, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28332480/honey-bee-hairs-and-pollenkitt-are-essential-for-pollen-capture-and-removal
#13
Guillermo J Amador, Marguerite Matherne, D'Andre Waller, Megha Mathews, Stanislav N Gorb, David L Hu
While insect grooming has been observed and documented for over one hundred years, we present the first quantitative analysis of this highly dynamic process. Pollinating insects, like honey bees, purposely cover themselves with millions of pollen particles that, if left ungroomed, would make sensing and controlled flight difficult. How do they get clean? We show that the hairs on insect eyes are tuned to the pollen they collect; namely, the hairs are spaced so that they suspend pollen above the body for easy removal by the forelegs...
March 23, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28331587/a-simple-fast-and-repeatable-survey-method-for-underwater-visual-3d-benthic-mapping-and-monitoring
#14
Oscar Pizarro, Ariell Friedman, Mitch Bryson, Stefan B Williams, Joshua Madin
Visual 3D reconstruction techniques provide rich ecological and habitat structural information from underwater imagery. However, an unaided swimmer or diver struggles to navigate precisely over larger extents with consistent image overlap needed for visual reconstruction. While underwater robots have demonstrated systematic coverage of areas much larger than the footprint of a single image, access to suitable robotic systems is limited and requires specialized operators. Furthermore, robots are poor at navigating hydrodynamic habitats such as shallow coral reefs...
March 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28330416/the-way-to-cover-prediction-for-cytotoxicity-for-all-existing-nano-sized-metal-oxides-by-using-neural-network-method
#15
Natalja Fjodorova, Marjana Novic, Agnieszka Gajewicz, Bakhtiyor Rasulev
The regulatory agencies should fulfil the data gap in toxicity for new chemicals including nano-sized compounds, like metal oxides nanoparticles (MeOx NPs) according to the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) legislation policy. The present study demonstrates the perspective capability of neural network models for prediction of cytotoxicity of MeOx NPs to bacteria Escherichia coli (E. coli) for the widest range of metal oxides extracted from Periodic table. The Counter Propagation Artificial Neural Network (CP ANN) models for prediction of cytotoxicity of MeOx NPs for data sets of 17, 36 and 72 metal oxides were employed in the study...
March 23, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28330075/a-novel-multiplex-pcr-method-for-the-detection-of-virulence-associated-genes-of-escherichia-coli-o157-h7-in-food
#16
Vo Van Giau, Thuy Trang Nguyen, Thi Kim Oanh Nguyen, Thi Thuy Hang Le, Tien Dung Nguyen
Shiga toxin-producing Escherichia coli O157:H7 (E. coli O157:H7) strains are foodborne infectious agents that cause a number of life-threatening diseases, including hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). Shiga toxin 1 (stx1), shiga toxin 2 (stx2), or a combination of both are responsible for most clinical symptoms of these diseases. Hence, various diagnostic methods have been developed so far to detect shiga toxins such as cell culture, ELISA, Rapid Latex Agglutination (RPLA) and hybridization, but due to high costs and labor time in addition to low sensitivity, they have not received much attention...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329639/development-and-validation-of-the-basal-and-squamous-cell-carcinoma-quality-of-life-basqol-questionnaire
#17
Rick Waalboer-Spuij, Loes M Hollestein, Reinier Timman, Lonneke V Van de Poll-Franse, Tamar E C Nijsten
Health-related quality of life is increasingly important in the management of patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). A few disease-specific questionnaires exist, but all with substantial flaws. We developed and validated a quality of life questionnaire suitable for use in all BCC and SCC patients. In an extensive four-phase trajectory, as recommended by the European Organisation for Research and Treatment of Cancer (EORTC), 33 items were selected and rephrased into a preliminary questionnaire...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328350/risk-factors-for-and-spatial-distribution-of-lymphoproliferative-disease-virus-lpdv-in-wild-turkeys-meleagris-gallopavo-in-new-york-state-usa
#18
Katrina Alger, Elizabeth Bunting, Krysten Schuler, Christopher M Whipps
Lymphoproliferative disease virus (LPDV) is an oncogenic avian retrovirus that was previously thought to exclusively infect domestic turkeys but was recently shown to be widespread in Wild Turkeys ( Meleagris gallopavo ) throughout most of the eastern US. In commercial flocks, the virus spreads between birds housed in close quarters, but there is little information about potential risk factors for infection in wild birds. Initial studies focused on distribution of LPDV nationally, but investigation of state-level data is necessary to assess potential predictors of infection and detect patterns in disease prevalence and distribution...
March 22, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28328026/alternative-mass-reference-standards-for-direct-analysis-in-real-time-mass-spectrometry
#19
Robert B Cody, A John Dane
RATIONALE: Mass spectra were acquired with the Direct Analysis in Real Time (DART®) ion source for an amine-terminated polyether used as positive-ion mass reference standards and for several fluorinated materials commonly used as negative-ion reference standards for mass spectrometry. METHODS: A commercial time-of-flight mass spectrometer equipped with a DART ion source was used for all measurements. Mass reference standards deposited onto the sealed end of a glass melting point tube were suspended in the DART gas stream for analysis...
May 30, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28327742/pair-natural-orbital-and-canonical-coupled-cluster-reaction-enthalpies-involving-light-to-heavy-alkali-and-alkaline-earth-metals-the-importance-of-sub-valence-correlation
#20
Yury Minenkov, Giovanni Bistoni, Christoph Riplinger, Alexander A Auer, Frank Neese, Luigi Cavallo
In this work, we tested canonical and domain based pair natural orbital coupled cluster methods (CCSD(T) and DLPNO-CCSD(T), respectively) for a set of 32 ligand exchange and association/dissociation reaction enthalpies involving ionic complexes of Li, Be, Na, Mg, Ca, Sr, Ba and Pb(ii). Two strategies were investigated: in the former, only valence electrons were included in the correlation treatment, giving rise to the computationally very efficient FC (frozen core) approach; in the latter, all non-ECP electrons were included in the correlation treatment, giving rise to the AE (all electron) approach...
March 22, 2017: Physical Chemistry Chemical Physics: PCCP
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