keyword
Keywords Chronic pancreatitis calcifica...

Chronic pancreatitis calcification risk factors

https://read.qxmd.com/read/32253728/primary-hyperparathyroidism-and-pancreatitis
#21
JOURNAL ARTICLE
R A Misgar, M H Bhat, T A Rather, S R Masoodi, A I Wani, M I Bashir, M A Wani, A A Malik
PURPOSE: The true association between primary hyperparathyroidism (PHPT) and pancreatitis continues to be controversial. In this study, we present clinical data, investigative profile, management and follow-up of PHPT patients with pancreatitis and compare this group with PHPT patients without pancreatitis. METHODS: Records of 242 patients with PHPT managed at our center over 24 years were retrospectively analyzed for demographic and laboratory data. The diagnosis of pancreatitis was entertained in the presence of at least two of the three following features: abdominal pain, levels of serum amylase greater than three times the normal or characteristic features at imaging...
October 2020: Journal of Endocrinological Investigation
https://read.qxmd.com/read/32213024/multiple-risk-factors-for-diabetes-mellitus-in-patients-with-chronic-pancreatitis-a-multicentre-study-of-1117-cases
#22
JOURNAL ARTICLE
Søren S Olesen, Jakob L Poulsen, Srdan Novovic, Camilla Nøjgaard, Evangelos Kalaitzakis, Nanna M Jensen, Trond Engjom, Erling Tjora, Anne Waage, Truls Hauge, Stephan L Haas, Miroslav Vujasinovic, Giedrius Barauskas, Aldis Pukitis, Imanta Ozola-Zālīte, Alexey Okhlobystin, Mikael Parhiala, Johanna Laukkarinen, Asbjørn M Drewes
BACKGROUND: Diabetes mellitus is a common complication of chronic pancreatitis. It is traditionally considered to develop as a consequence of beta cell loss, but there might be additional factors. Recent studies have highlighted the importance of type 2 diabetes-related risk factors in this context and population-based studies show increased risk of diabetes following acute pancreatitis. The aim of this study was to explore multiple risk factors for diabetes in patients with chronic pancreatitis...
January 17, 2020: United European Gastroenterology Journal
https://read.qxmd.com/read/32107194/natural-course-of-chronic-pancreatitis-and-predictors-of-its-progression
#23
JOURNAL ARTICLE
Samagra Agarwal, Sanchit Sharma, Deepak Gunjan, Namrata Singh, Kanav Kaushal, Shekhar Poudel, Abhinav Anand, Srikant Gopi, Srikant Mohta, Ujjwal Sonika, Anoop Saraya
BACKGROUND: The natural course of chronic pancreatitis(CP) and its complications has been inadequately explored. We aimed to describe the natural history and factors affecting the progression of alcoholic(ACP), idiopathic juvenile(IJCP) and idiopathic senile(ISCP) variants of CP. METHODS: This study was a retrospective analysis from a prospectively maintained database of patients with CP following up at a tertiary care centre from 1998 to 2019. Cumulative rates of pain resolution, diabetes, steatorrhea, pseudocysts and pancreatic cancer were computed using Kaplan-Meier analysis, and the factors affecting their incidence were identified on multivariable-adjusted Cox-proportional-hazards model...
April 2020: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/32045995/pancreatic-fibrosis-and-chronic-pancreatitis-mini-review-of-non-histologic-diagnosis-for-clinical-applications
#24
REVIEW
Chung-Tsui Huang, Cheng-Kuan Lin, Tzong-Hsi Lee, Yao-Jen Liang
Pancreatic fibrosis is the dominant reversible pathological change and diagnostic factor in early chronic pancreatitis, defined by a mechanistic approach proposed in 2016. Main guidelines for chronic pancreatitis were published by the American Pancreas Association in 2014, the Japanese Society of Gastroenterology in 2015, and United European Gastroenterology in 2017. All three sets of guidelines mentioned that the staging of chronic pancreatitis is important but challenging. There are various image modalities for the non-histologic diagnosis of pancreatic fibrosis: (1) shear wave elastography, such as an acoustic radiation force impulse with a cut-off value of 1...
February 7, 2020: Diagnostics
https://read.qxmd.com/read/31860051/diagnosis-and-management-of-chronic-pancreatitis-a-review
#25
REVIEW
Vikesh K Singh, Dhiraj Yadav, Pramod K Garg
IMPORTANCE: Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas with a prevalence of 42 to 73 per 100 000 adults in the United States. OBSERVATIONS: Both genetic and environmental factors are thought to contribute to the pathogenesis of CP. Environmental factors associated with CP include alcohol abuse (odds ratio [OR], 3.1; 95% CI, 1.87-5.14) for 5 or more drinks per day vs abstainers and light drinkers as well as smoking (OR, 4...
December 24, 2019: JAMA
https://read.qxmd.com/read/31593013/risk-factors-associated-with-progression-toward-endocrine-insufficiency-in-chronic-pancreatitis
#26
JOURNAL ARTICLE
Barite W Gutama, Yi Yang, Gregory J Beilman, Martin L Freeman, Varvara A Kirchner, Timothy L Pruett, Srinath Chinnakotla, Elissa M Downs, Guru Trikudanathan, Sarah J Schwarzenberg, James S Hodges, Melena D Bellin
OBJECTIVE: Little data exist describing the change over time in islet function and glycemic control in patients with chronic pancreatitis (CP). METHODS: In 325 CP patients who underwent 2 mixed meal tolerance tests and/or glycated hemoglobin (HbA1c) levels, we estimated the rate of change in metabolic measures per 6 months and assessed the association between potential risk factors for diabetes and rate of change using multivariate regression models. RESULTS: Per 6-month time, HbA1c increased by 0...
October 2019: Pancreas
https://read.qxmd.com/read/31462382/pancreatic-calcifications-associate-with-diverse-aetiological-risk-factors-in-patients-with-chronic-pancreatitis-a-multicentre-study-of-1500-cases
#27
MULTICENTER STUDY
Søren S Olesen, Maria Valeryevna Lisitskaya, Asbjørn M Drewes, Srdan Novovic, Camilla Nøjgaard, Evangelos Kalaitzakis, Nanna M Jensen, Trond Engjom, Friedemann Erchinger, Anne Waage, Truls Hauge, Stephan L Haas, Miroslav Vujasinovic, Björn Lindkvist, Kristina Zviniene, Aldis Pukitis, Imanta Ozola-Zālīte, Alexey Okhlobystin, Mikael Parhiala, Johanna Laukkarinen, Jens B Frøkjær
BACKGROUND: Pancreatic calcifications is a common finding in patients with chronic pancreatitis (CP), but the underlying pathophysiology is incompletely understood. Past studies for risk factors of calcifications have generally been focused on single parameters or limited by small sample sizes. The aim of this study was to explore several patient and disease characteristics and their associations with pancreatic calcifications in a large cohort of CP patients with diverse aetiological risk factors...
October 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/31378749/a-new-insight-into-chronic-pancreatitis
#28
REVIEW
Tooru Shimosegawa
Chronic pancreatitis (CP) is a pancreatic disease with poor prognosis characterized clinically by abdominal pain, morphologically by pancreatic stones/calcification, duct dilatation and atrophy, and functionally by pancreatic exocrine and endocrine insufficiency. CP is also known as a risk factor for the development of pancreatic cancer. CP has long been understood based on a fixed disease concept deduced from the clinical and morphological features of the end-stage disease. However, identification of causal genes for hereditary pancreatitis and success in the isolation and culture of pancreatic stellate cells have advanced the understanding of the underlying pathological mechanisms, the early-stage pathophysiology, and the mechanisms behind pancreatic fibrosis...
August 2019: Tohoku Journal of Experimental Medicine
https://read.qxmd.com/read/31111533/significance-of-pancreatic-calcification-on-preoperative-computed-tomography-of-intraductal-papillary-mucinous-neoplasms
#29
COMPARATIVE STUDY
Masahiro Tsujimae, Atsuhiro Masuda, Hideyuki Shiomi, Hirochika Toyama, Keitaro Sofue, Eisuke Ueshima, Kohei Yamakawa, Shigeto Ashina, Yasutaka Yamada, Takeshi Tanaka, Shunta Tanaka, Ryota Nakano, Yu Sato, Takuya Ikegawa, Manabu Kurosawa, Seiji Fujigaki, Takashi Kobayashi, Arata Sakai, Hiromu Kutsumi, Yoh Zen, Tomoo Itoh, Takumi Fukumoto, Yuzo Kodama
BACKGROUND AND AIM: Chronic pancreatitis is a risk factor for pancreatic cancer. Pancreatic calcification is a characteristic of chronic pancreatitis; however, its significance for intraductal papillary mucinous neoplasm (IPMN) oncogenesis remains unknown. Therefore, we investigated the relationship between pancreatic calcification and invasive IPMN. METHODS: This study included 157 patients who underwent resection for IPMN between April 2001 and October 2016 (intraductal papillary mucinous adenoma, n = 76; noninvasive intraductal papillary mucinous carcinoma [IPMC], n = 32; and invasive IPMC, n = 49)...
September 2019: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/30903611/impact-of-calcifications-on-diagnostic-yield-of-endoscopic-ultrasound-guided-fine-needle-aspiration-for-pancreatic-ductal-adenocarcinoma
#30
JOURNAL ARTICLE
Anoop K Koshy, Rao B Harshavardhan, Ismail Siyad, Rama P Venu
INTRODUCTION: Chronic calcific pancreatitis (CCP) is a major risk factor for pancreatic ductal adenocarcinoma (PDAC) and is common in southern India. Endoscopic ultrasound fine-needle aspiration (EUS-FNA) is useful for tissue acquisition in patients with solid pancreatic lesions. Multiple factors may affect the diagnostic yield of FNA samples. The present study was performed to assess the impact of pancreatic calcifications on the diagnostic yield of EUS-FNA in PDAC. METHODS: All patients with confirmed PDAC from January 2013 to December 2017 were included...
April 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/28880010/chronic-pancreatitis
#31
REVIEW
Jorg Kleeff, David C Whitcomb, Tooru Shimosegawa, Irene Esposito, Markus M Lerch, Thomas Gress, Julia Mayerle, Asbjørn Mohr Drewes, Vinciane Rebours, Fatih Akisik, J Enrique Domínguez Muñoz, John P Neoptolemos
Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the pancreas in individuals with genetic, environmental and/or other risk factors who develop persistent pathological responses to parenchymal injury or stress. Potential causes can include toxic factors (such as alcohol or smoking), metabolic abnormalities, idiopathic mechanisms, genetics, autoimmune responses and obstructive mechanisms. The pathophysiology of chronic pancreatitis is fairly complex and includes acinar cell injury, acinar stress responses, duct dysfunction, persistent or altered inflammation, and/or neuro-immune crosstalk, but these mechanisms are not completely understood...
September 7, 2017: Nature Reviews. Disease Primers
https://read.qxmd.com/read/28741615/patient-and-disease-characteristics-associated-with-the-presence-of-diabetes-mellitus-in-adults-with-chronic-pancreatitis-in-the-united-states
#32
JOURNAL ARTICLE
Melena D Bellin, David C Whitcomb, Judah Abberbock, Stuart Sherman, Bimaljit S Sandhu, Timothy B Gardner, Michelle A Anderson, Michele D Lewis, Samer Alkaade, Vikesh K Singh, John Baillie, Peter A Banks, Darwin Conwell, Gregory A Cote, Nalini M Guda, Thiruvengadam Muniraj, Gong Tang, Randall E Brand, Andres Gelrud, Stephen T Amann, Christopher E Forsmark, C Mel Wilcox, Adam Slivka, Dhiraj Yadav
OBJECTIVES: Diabetes mellitus (DM) is a common complication of chronic pancreatitis (CP). Past studies for DM risk factors in CP have been limited to single centers or highly focused on a single etiology such as alcoholic or hereditary disease. We studied risk factors for DM in a large population of patients with CP of all etiologies enrolled in the North American Pancreatitis 2 studies. METHODS: Participants (1,171) with CP (n=383 with DM, n=788 without DM) were enrolled prospectively from 26 participating centers...
September 2017: American Journal of Gastroenterology
https://read.qxmd.com/read/28520452/-relapsing-autoimmune-pancreatitis-type-1-case-report
#33
REVIEW
Alena Ondrejková, Bohuslav Kianička, Hana Nechutová, Lukáš Hruška, Ivo Novotný, Miroslav Souček
Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis, classified into 2 subtypes - AIP type 1 and AIP type 2. We present a case of a 31-years-old female admitted to our institution with upper abdominal pain and obstructive jaundice. Endoscopic retrograde cholangiopancreatoscopy (ERCP) revealed stenosis of intrapancreatic distal bile duct. Diffuse parenchymal enlargement and typical features of AIP were shown by computed tomography (CT) and endoscopic ultrasonography (EUS). The patient´s serum IgG4 was elevated at 3...
December 0: Vnitr̆ní Lékar̆ství
https://read.qxmd.com/read/28315036/diagnosing-chronic-pancreatitis
#34
REVIEW
Ahmad Anaizi, Phil A Hart, Darwin L Conwell
Diagnosing CP can range from routine in those with severe disease and obvious calcifications on CT imaging to elusive in those patients with early changes in CP. The workup of suspected CP should follow a progressively noninvasive to more invasive STEP-wise approach in a patient with a suspicious clinical presentation and risk factors that raise their pretest probability of disease. After a thorough history and physical examination, basic laboratories should be obtained such as lipase, amylase, metabolic panel, and indirect PFTs (fecal elastase-1, serum trypsin)...
July 2017: Digestive Diseases and Sciences
https://read.qxmd.com/read/28027749/pancreatic-cancer-in-patients-with-chronic-calcifying-pancreatitis-computed-tomography-findings-a-retrospective-analysis-of-48-patients
#35
JOURNAL ARTICLE
Amir Mohamed, Ahmet Ayav, Arthur Belle, Xavier Orry, Jean-Baptiste Chevaux, Valerie Laurent
OBJECTIVE: Chronic calcifying pancreatitis (CCP) is a risk factor for pancreatic cancer (PC). Symptoms of PC are non-specific in patients with CCP, and diagnostic imaging can be difficult. Some studies have shown that diagnosis may take several months, leading to delays in treatment (Lin et al., 2015; Lennon et al., 2014) [2,3]. The aim of this study was to describe the radiological signs of PC in patients with CCP. METHODS: This retrospective, single-center study was conducted between January 2004 and December 2014...
January 2017: European Journal of Radiology
https://read.qxmd.com/read/27527745/racial-differences-in-the-clinical-profile-causes-and-outcome-of-chronic-pancreatitis
#36
JOURNAL ARTICLE
C Mel Wilcox, Bimaljit S Sandhu, Vikesh Singh, Andres Gelrud, Judah N Abberbock, Stuart Sherman, Gregory A Cote, Samer Al-Kaade, Michelle A Anderson, Timothy B Gardner, Michele D Lewis, Christopher E Forsmark, Nalini M Guda, Joseph Romagnuolo, John Baillie, Stephen T Amann, Thiruvengadam Muniraj, Gong Tang, Darwin L Conwell, Peter A Banks, Randall E Brand, Adam Slivka, David Whitcomb, Dhiraj Yadav
OBJECTIVES: Racial differences in susceptibility and progression of pancreatitis have been reported in epidemiologic studies using administrative or retrospective data. There has been little study, however, on the clinical profile, causes, and outcome of chronic pancreatitis (CP) in black patients. METHODS: We analyzed data on black patients with CP prospectively enrolled in the multicenter North American Pancreatitis Studies from 26 US centers during the years 2000-2014...
October 2016: American Journal of Gastroenterology
https://read.qxmd.com/read/27312075/spanish-multicenter-study-to-estimate-the-incidence-of-chronic-pancreatitis
#37
MULTICENTER STUDY
J Enrique Domínguez Muñoz, Alfredo José Lucendo Villarín, L Fernando Carballo Álvarez, Jose María Tenías, Julio Iglesias García
OBJECTIVE: To estimate the incidence of chronic pancreatitis in Spain as diagnosed with endoscopic ultrasound (EUS), and to assess the risk factors and complications detected. MATERIAL AND METHOD: A descriptive, observational study of chronic pancreatitis cases diagnosed in Spanish health care centers with an EUS unit. A structured questionnaire was used to evaluate the incidence of the disease (cases identified over 18 months: from January 2011 to June 2012), risk factors, EUS criteria, Rosemont classification, and frequency of local complications...
July 2016: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/26958679/chronic-pancreatitis-in-a-patient-with-the-p-asn34ser-homozygous-spink1-mutation-own-experience
#38
JOURNAL ARTICLE
Agnieszka Magdalena Rygiel, Małgorzata Wojnicka-Stolarz, Katarzyna Niepokój, Grzegorz Oracz, Jerzy Bal, Katarzyna Wertheim-Tysarowska, Krzysztof Gutkowski
Chronic pancreatitis (CP) is characterized by progressive damage to the exocrine and endocrine cell structures and pancreatic ducts with subsequent fibrosis of the organ. Patients with no apparent etiological factor are classified as having idiopathic CP (ICP). Genetic studies indicate the importance of mutations in the serine protease inhibitor, Kazal type 1 gene (SPINK1) in the pathogenesis of CP This report describes a case of a 29-year-old Polish-Vietnamese patient with the p.Asn34Ser (p.N34S) homozygous mutation in the SPINK1 gene...
July 2015: Developmental Period Medicine
https://read.qxmd.com/read/26924663/chronic-pancreatitis-an-international-draft-consensus-proposal-for-a-new-mechanistic-definition
#39
JOURNAL ARTICLE
David C Whitcomb, Luca Frulloni, Pramod Garg, Julia B Greer, Alexander Schneider, Dhiraj Yadav, Tooru Shimosegawa
BACKGROUND: A definition of chronic pancreatitis (CP) is needed for diagnosis and distinguishing CP from other disorders. Previous definitions focused on morphology. Advances in epidemiology, genetics, molecular biology, modeling and other disciplines provide new insights into pathogenesis of CP, and allow CP to be better defined. METHODS: Expert physician-scientists from the United States, India, Europe and Japan reviewed medical and scientific literature and clinical experiences...
March 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/26601825/association-between-smoking-and-the-progression-of-computed-tomography-findings-in-chronic-pancreatitis
#40
JOURNAL ARTICLE
Jeong Woo Lee, Ho Gak Kim, Dong Wook Lee, Jimin Han, Hyuk Yong Kwon, Chang Jin Seo, Ji Hye Oh, Joo Hyoung Lee, Jin Tae Jung, Joong Goo Kwon, Eun Young Kim
BACKGROUND/AIMS: Smoking and alcohol intake are two wellknown risk factors for chronic pancreatitis. However, there are few studies examining the association between smoking and changes in computed tomography (CT) findings in chronic pancreatitis. The authors evaluated associations between smoking, drinking and the progression of calcification on CT in chronic pancreatitis. METHODS: In this retrospective study, 59 patients with chronic pancreatitis who had undergone initial and follow-up CT between January 2002 and September 2010 were included...
May 23, 2016: Gut and Liver
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