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A Carver, K Chell, T E Davison, B M Masser
BACKGROUND AND OBJECTIVES: Effective recruitment and retention of male donors are vital for the ongoing provision of blood products. Compared with females, male donors are less likely to be medically deferred or experience vasovagal reactions and are typically preferred for plasmapheresis donation in voluntary non-remunerated settings. However, females outnumber males among donors aged under 40 years. This systematic review aimed to synthesize evidence and identify key motivators for blood donation among males to inform targeted recruitment/retention campaigns...
April 2018: Vox Sanguinis
Hong Wang, Yuan Huang, Chun-Wei Xu, Li Lin
OBJECTIVE: To analyze the differences of the clinical characteristics and risk factors between tumor and non-tumor patients complicated with pulmonary embolism. METHODS: A retrospective analysis was conducted on 96 hospitalized patients complicated with pulmonary embolism admitted into 307 Hospital of PLA from January 2009 to December 2014. 96 cases were divided into tumor group (n=52) and non-tumor group (n=44) according to whether they were accompanied with malignant tumors...
2015: International Journal of Clinical and Experimental Medicine
Takashi Sugiyama, Tsuyoshi Uchiyama, Hirotsugu Takashima, Daisuke Yamamoto, Keishiro Sato, Takako Shimizu, Yoshiro Otsuki, Toshihiko Ohashi
One explanation for cerebral infarctions that occur as a complication of pneumococcal meningitis is blood coagulation abnormalities. We investigated the clinical features, laboratory test results, magnetic resonance imaging (MRI) findings, and pathological features of 10 patients with pneumococcal meningitis between 2006 and 2013 to examine the abnormal findings that may be associated with prognosis. Five patients (50%) that had Glasgow Outcome Scale scores between 1 and 4 were classified as the poor outcome group...
2015: Rinshō Shinkeigaku, Clinical Neurology
Ali Modarressi
Autologous fat transfer offers many qualities of a ideal soft tissue filler. Main advantages of fat grafting ensue from the fact that the lipoaspirate tissue is an abundant source of regenerative pluripotential cells. However, the reported rates of fat cell survival vary greatly in the medical literature (10-90%). Different techniques of harvesting, processing, and reinjecting the fat cells are so claimed to be responsible for these differences, without any agreement concerning the best way to process. To address this important disadvantage, we propose the addition of autologous platelet rich plasma (PRP) which is known as a natural reservoir of growth factors stimulating tissue repair and regeneration...
January 2013: World Journal of Plastic Surgery
Anna L Dengate, Marie-Christine Morel-Kopp, Julia A Beatty, Vanessa Barrs, Jody A Braddock, Richard K Churcher, Bethany J Wilson, Christopher M Ward
OBJECTIVE: To optimize the overall hemostasis potential (OHP) assay for use with canine platelet-poor plasma and determine reference intervals in healthy dogs. ANIMALS: 40 healthy dogs. PROCEDURES: Blood was collected from the dogs into citrated tubes, and platlet-poor plasma was obtained. The OHP assay and standard coagulation assays (prothrombin time, activated partial thromboplastin time, and fibrinogen concentration) were performed for each sample...
December 2013: American Journal of Veterinary Research
Yan-ting Cao, Jin-ning Lou, Wen-jian Zhang, Li-ya Ye, Hong-lin Liu, Cheng-hui Li
OBJECTIVE: To investigate the effects of platelet on intercellular adhesion between leukocyte and liver sinusoidal endothelial cell(LSEC) and the transendothelial migration under the hypoxia-reoxygenation condition, as well as the role of relevant adhesion molecules. METHOD: LSEC was cultured for 24 hours under hypoxia condition and then reoxygenated for 2 hours (hypoxia-reoxygenation, HR). This hypoxia-reoxygenation model was used to simulate the clinical liver ischemia-reperfusion injury process (IRI)...
April 2, 2013: Zhonghua Yi Xue za Zhi [Chinese medical journal]
J Fassl, H Riha, H Ramakrishna, N Singh, T Wyckoff, C Roscher, J G T Augoustides
The hybrid operating room is the venue for transcatheter therapy with the convergence of three specialties: cardiac surgery, cardiovascular anesthesiology, and interventional cardiology. Transcatheter aortic valve replacement is proof that cardiac specialists have embraced the endovascular revolution. Since pharmacologic and ischemic myocardial conditioning are safe and effective, they are currently the focus of multiple trials. Angiotensin blockade, anemia and endoscopic saphenous vein harvesting worsen outcome after coronary artery bypass grafting (CABG)...
2010: HSR Proceedings in Intensive Care & Cardiovascular Anesthesia
Tiziana Martinello, Ilaria Bronzini, Anna Perazzi, Stefania Testoni, Gulia Maria De Benedictis, Alessandro Negro, Giovanni Caporale, Francesco Mascarello, Ilaria Iacopetti, Marco Patruno
Tendon injuries, degenerative tendinopathies, and overuse tendinitis are common in races horses. Novel therapies aim to restore tendon functionality by means of cell-based therapy, growth factor delivery, and tissue engineering approaches. This study examined the use of autologous mesenchymal stromal cells derived from peripheral blood (PB-MSCs), platelet-rich plasma (PRP) and a combination of both for ameliorating experimental lesions on deep digital flexor tendons (DDFT) of Bergamasca sheep. In particular, testing the combination of blood-derived MSCs and PRP in an experimental animal model represents one of the few studies exploring a putative synergistic action of these treatments...
February 2013: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Mahlon D Johnson, Mary O'Connell, M Anwar Iqbal, Jacqueline P Williams
PURPOSE: The pathogenesis of meningiomas remains largely unknown, but there is evidence that exposure radiation increases the risk of meningiomas. We therefore evaluated whether radiation stimulates human leptomeningeal cell proliferation and activates growth regulatory pathways. MATERIALS AND METHODS: Cultures from six human primary leptomeningeal cells were established and irradiated with 0.5, 1 or 2 Gy. Cells were subsequently maintained for approximately 3-6 months and then treated with the mitogen, platlet-derived growth factor-BB (PDGF-BB), or human cerebrospinal fluid (CSF) obtained from patients with no neurological disease...
July 2012: International Journal of Radiation Biology
J Vanithamani, V Selvi, B G Krishnaswamy
Diabetes mellitus, a metabolic disorder, is characterized by hyperglycemia and altered metabolism. The administration of D-Nil plus (a polyherbal drug) showed effective treatment for alloxan induced diabetes in rats. In diabetic rats, haematological profiles namely RBC, WBC, platlet count and haemoglobin were decreased whereas ESR was increased. Similarly biochemical parameters creatinine, urea and protein were decreased but cholesterol level was increased. After the treatment with D-Nil plus, haematological parameters and biochemical parameters were reversed...
January 2006: Ancient Science of Life
Zhen-zhen Sun, Ke-ming Zhu, Xiao-ming Deng
No abstract text is available yet for this article.
August 2011: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, Chinese Critical Care Medicine, Zhongguo Weizhongbing Jijiuyixue
E Ippolito, A Molinari, S Romagnoli, G Belcaro, M R Cesarone, F Urgnani, P Bonadeo
AIM: Locoregional thrombolytic therapy has emerged in the last years as the treatment of choise for iliofemoral deep vein thrombosis, preserving the structural and functional integrity of vein walls. We studied the efficacy and complication rates of direct regional thrombolytic therapy in acute venous thrombosis of lower extremities. METHODS: Between January 2002 and March 2007, 8 selected patients with acute extensive and symptomatic iliofemoral or femoral-popliteal venous thrombosis were treated with flow-direct regional thrombolytic therapy...
October 2008: Minerva Cardioangiologica
Sorabh Kapoor, Sujoy Pal, Peush Sahni, Tushar K Chattopadhyay
BACKGROUND AND AIMS: Non-cirrhotic portal hypertension due to extrahepatic portal vein thrombosis (EHO) and non-cirrhotic portal fibrosis (NCPF) is a major cause of upper gastrointestinal hemorrhage in India. Hypercoagulability has been proposed to explain the thrombosis in the portal vein in EHO and intrahepatic portal vein radicals in NCPF. However, some authors have reported hypocoagulability in these patients. Thromboelastography (TEG), which gives a dynamic assessment of coagulation, has potential for evaluating coagulation in these patients but has not been used so far...
June 2009: Journal of Gastroenterology and Hepatology
Vjekoslav Gerc, Marko Buksa
Statins are utilised in the primary and secondary prevention of coronary heart disease, due to their efficacy at lowering lipid levels. However, statins may also prevent atherosclerosis disease by non-lipid or pleiotropic effects, for example, improving endothelial function by promoting the production of NO. By increasing NO production, statins may interfere with atherosclerosis lesion developement, stabilise plaque, inhibit platlet aggregation, improve blood flow and protect against ischaemia. Therofore, the ability of statins to improve endothelial function through the release of NO may partialy account for their beneficial effects at reducing the incidence of cardiovascular events...
2006: Medicinski Arhiv
Ai-hua Liang, Chang-an Yu, Chun-ying Li, Bao-yun Xue, Jin-hua Wang, Lu-qu Huang
OBJECTIVE: To compare the development of thrombosis animal model induced by endotoxin(LPS) in combination with carrageenan (Ca) in different animals. METHOD: Two species of rats (SD and Wistar) and three species of mice (Kunming, ICR and Balb/c mice) were employed in the study. The animals of each species were randomly divided into control group and model group (LPS/Ca treatment). The animals in the model group were pretreated with Ca ip at the doses of 25 mg x kg(-1) for rats and 150 mg x kg(-1) for mice, and then treated by LPS iv sixteen hours later, while in the control group were given normal saline (NS)...
January 2006: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Shao-Ling Gu, Can Liao, Shao-Qing Wu, Jin-Song Chen, Zun-Peng Xu, Bin Liu
The objective of this research was to explore whether the number of CD34(+)CD38(+) cells infused affects hematopoietic reconstitution after cord blood transplantation. The number of CD34(+)CD38(+) cells in cord blood was analysed with flow cytometry after freezethawing. The body weight and time for neutrophil and platelet recovery were measured in 20 children with acute leukemia. The results showed that the median number of CD34(+)CD38(+) cells infused was 29.47 (9.85 - 325.71) x 10(4)/kg. A median time for neutrophil recovery (> 5 x 10(8)/L) in 20 patients was 18...
August 2003: Zhongguo Shi Yan Xue Ye Xue za Zhi
Fumio Kimura, Hiroshi Itoh, Satoshi Ambiru, Hiroaki Shimizu, Akira Togawa, Hiroyuki Yoshidome, Masayuki Ohtsuka, Yoshiaki Shimizu, Fumihiko Shimamura, Masaru Miyazaki
OBJECTIVE: Although splenectomy is a standard surgical treatment for chronic idiopathic thrombocytopenic purpura, partial splenic embolization is another treatment option. We retrospectively studied the long-term results of initial and repeated partial splenic embolization. MATERIALS AND METHODS: Thirty-nine patients, 15 men and 24 women, underwent initial embolization; 12 of the 39 underwent a repeated embolization. The therapeutic effects of the initial and repeated embolization were classified as a complete response if the patient's platelet count rose to more than 10 x 10(4)/ micro L without medication 1 year after the initial or repeated embolization, as a partial response if the platlet count reached 5-10 x 10(4)/ micro L under the same circumstances, or as no response...
November 2002: AJR. American Journal of Roentgenology
Z Tian, N Gao, L Li, J Yu, X Luo
OBJECTIVE: To find and define the effective fraction of Lycopus lucidus on coagulation. METHODS: Method of comparing turbidity, method of cutting a part of the mice tail and method of breaking glass tube. RESULTS: The two extracted fraction from lycopus lucidus F04-0A and F04-B could inhibit rats platlet aggregation in vitro and mice platelet aggregation in vivo. They could also prolong mice blood coagulation time. However, they had no effect on bleeding time...
July 2001: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
H Endo, T Naito, T Asahara, M Kajima, H Shiota
PURPOSE: To determine the relation between vascular endothelial growth factor (VEGF) and platlet-derived growth factor (PDGF) in the vitreous fluids from patients with proliferative diabetic retinopathy (PDR). SUBJECTS AND METHOD: Concentrations of VEGF and PDGF in the vitreous fluids from 53 eyes, 31 eyes in 30 PDR patients and 22 eyes in 22 non diabetes mellitus(DM) patients serving as controls, were measured by enzyme-linked immunosolvent assay. The levels of VEGF and PDGF were compared between PDR and non DM patients...
October 2000: Nippon Ganka Gakkai Zasshi
T Hashimoto
Clinicopathologically, Behçet's disease is characterized by neutrophil and platlet hyperfunction. Lesions are formed presumably because neutrophils infiltrating the affected tissue release active oxygen and lysosomal enzymes in large amounts. The mechanisms of neutrophil hyperfunction was obscure, but in recent years attention has focused on the effects of cytokines released by mononuclear cells. As more has been learned about the etiopathogenesis of Behçet's disease, novel anti-inflammatory drugs, immunosuppressants, anti-thrombotic agents, and anticoagulants have helped to achieve remarkable progress of treatment...
February 1999: Nihon Rinsho. Japanese Journal of Clinical Medicine
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