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https://www.readbyqxmd.com/read/29689243/whole-exome-sequencing-identifies-unique-mutations-and-copy-number-losses-in-calcifying-fibrous-tumor-of-the-pleura-report-of-three-cases-and-review-of-the-literature
#1
Mitra Mehrad, William A LaFramboise, Maureen A Lyons, Humberto E Trejo Bittar, Samuel A Yousem
Calcifying fibrous tumor of the pleura (CFTP) is a rare mesenchymal tumor of unknown pathogenesis. The diagnosis often requires exclusion of other common entities. Our aim was to determine if genomic changes were associated with CFTP that could contribute to mechanisms underlying tumorigenesis. Three cases of CFTP with their corresponding uninvolved control lung tissue were identified. Two patients were male, and one was female (age range: 21-32years). Tumors were multifocal in two cases and solitary in one...
April 21, 2018: Human Pathology
https://www.readbyqxmd.com/read/29685023/extracorporeal-shockwave-therapy-versus-exercise-program-in-patients-with-low-back-pain-short-term-results-of-a-randomised-controlled-trial
#2
A Notarnicola, G Maccagnano, M F Gallone, L Mastromauro, F Rifino, V Pesce, I Covelli, B Moretti
The physiotherapy treatment of low back pain (LBP) with physical stimulation offers different possibilities of application. Until now, the physical therapies used in LBP are laser therapy, ultrasonotherapy and currents. We conducted a clinical trial in order to verify whether shockwave therapy, which is very effective in treating tendinopathies and fracture consolidation delays, leads to clinical and electromyographic improvement in patients affected by LBP. We randomized thirty patients affected by LBP treated with shock waves (shockwave group) or a standard protocol characterized by rehabilitative exercises (control group)...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29682749/stable-gastric-pentadecapeptide-bpc-157-in-honeybee-apis-mellifera-therapy-to-control-nosema-ceranae-invasions-in-apiary-conditions
#3
I Tlak Gajger, J Ribarić, M Smodiš Škerl, J Vlainić, P Sikirić
Nosema ceranae can cause major problems, such as immune suppression, gut epithelial cell degeneration, reduced honeybee lifespan, or suddenly colony collapse. As a novel approach in therapy, we hypothesize the stable gastric pentadecapeptide BPC 157 in honeybee therapy, to control N. ceranae invasions in apiary conditions: BPC 157 treated sugar syrup (0.25 L sugar syrup supplemented with 0.1 μg/ml BPC 157), as well as the pure sugar syrup (0.25 L sugar syrup; control), was administered to honeybee colonies in feeders situated under the roof of the hives, during 21 consecutive days, at the end of beekeeping season...
April 23, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29670905/cortical-bone-trajectory-screws-in-posterior-lumbar-interbody-fusion-minimally-invasive-surgery-for-maximal-muscle-sparing-a-prospective-comparative-study-with-the-traditional-open-technique
#4
Nicola Marengo, Marco Ajello, Michele Federico Pecoraro, Giulia Pilloni, Giovanni Vercelli, Fabio Cofano, Francesco Zenga, Alessandro Ducati, Diego Garbossa
Introduction: A prospective comparative study between classical posterior interbody fusion with peduncular screws and the new technique with divergent cortical screws was conducted. Material and Methods: Only patients with monosegmental degenerative disease were recruited into this study. We analyzed a cohort of 40 patients treated from January 2015 to March 2016 divided into 2 groups (20 patients went to traditional open surgery and 20 patients under mini-invasive strategy)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29669436/heme-oxygenase-1-influences-satellite-cells-and-progression-of-duchenne-muscular-dystrophy-in-mice
#5
Katarzyna Pietraszek-Gremplewicz, Magdalena Kozakowska, Iwona Bronisz-Budzynska, Maciej Ciesla, Olga Mucha, Paulina Podkalicka, Magdalena Madej, Urszula Glowniak, Krzysztof Tomasz Szade, Jacek Stepniewski, Mateusz Jez, Kalina Andrysiak, Karolina Bukowska-Strakova, Anna Kaminska, Anna Kostera-Pruszczyk, Alicja Jozkowicz, Agnieszka Loboda, Jozef Dulak
AIMS: Muscle damage in Duchenne Muscular Dystrophy (DMD) caused by the lack of dystrophin is strongly linked to inflammation. Heme oxygenase-1 (HO-1; Hmox1) is an anti-inflammatory and cytoprotective enzyme affecting myoblasts differentiation by inhibiting myomirs. The role of HO-1 has not been so far well addressed in DMD. RESULTS: In dystrophin-deficient mdx mice expression of Hmox1 in limb skeletal muscles and diaphragm is higher than in wild-type animals, being consistently elevated from 8 up to 52 weeks, both in myofibres and inflammatory leukocytes...
April 19, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29651255/sex-specific-skeletal-muscle-fatigability-and-decreased-mitochondrial-oxidative-capacity-in-adult-rats-exposed-to-postnatal-hyperoxia
#6
Laura H Tetri, Gary M Diffee, Gregory P Barton, Rudolf K Braun, Hannah E Yoder, Kristin Haraldsdottir, Marlowe W Eldridge, Kara N Goss
Premature birth affects more than 10% of live births, and is characterized by relative hyperoxia exposure in an immature host. Long-term consequences of preterm birth include decreased aerobic capacity, decreased muscular strength and endurance, and increased prevalence of metabolic diseases such as type 2 diabetes mellitus. Postnatal hyperoxia exposure in rodents is a well-established model of chronic lung disease of prematurity, and also recapitulates the pulmonary vascular, cardiovascular, and renal phenotype of premature birth...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29625557/case-report-lactic-acidosis-and-rhabdomyolysis-during-telbivudine-and-tenofovir-treatment-for-chronic-hepatitis-b
#7
Yue Ying, Yue-Kai Hu, Jia-Lin Jin, Ji-Ming Zhang, Wen-Hong Zhang, Yu-Xian Huang
BACKGROUND: Current treatment options for chronic hepatitis B (CHB) are pegylated interferon alpha and nucleoside analogues (NAs). NAs have relatively fewer side effects than interferon alpha, and generally well tolerated. Previously 12.9% of patients on telbivudine treatment were reported to develop severe elevation of serum creatine phosphokinase (CPK) levels, but related clinical disease, like lactic acidosis (LA) and rhabdomyolysis (RM) were rare. The pathophysiology may be mitochondrial toxicity, for the NAs inhibit not only hepatitis B virus (HBV) polymerase, but also the host mitochondrial DNA polymerase γ...
April 6, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29581825/novel-inhibitor-candidates-of-trpv2-prevent-damage-of-dystrophic-myocytes-and-ameliorate-against-dilated-cardiomyopathy-in-a-hamster-model
#8
Yuko Iwata, Yoshimi Katayama, Yasushi Okuno, Shigeo Wakabayashi
Transient receptor potential cation channel, subfamily V, member 2 (TRPV2) is a principal candidate for abnormal Ca2+ -entry pathways, which is a potential target for therapy of muscular dystrophy and cardiomyopathy. Here, an in silico drug screening and the following cell-based screening to measure the TRPV2 activation were carried out in HEK293 cells expressing TRPV2 using lead compounds (tranilast or SKF96365) and off-patent drug stocks. We identified 4 chemical compounds containing amino-benzoyl groups and 1 compound (lumin) containing an ethylquinolinium group as candidate TRPV2 inhibitors...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29574248/embryonic-only-arsenic-exposure-alters-skeletal-muscle-satellite-cell-function-in-killifish-fundulus-heteroclitus
#9
Dana B Szymkowicz, Katey L Schwendinger, Caroline M Tatnall, John R Swetenburg, Lisa J Bain
Arsenic is a contaminant found worldwide in drinking water and food. Epidemiological studies have correlated arsenic exposure with reduced weight gain and improper muscular development, while in vitro studies show that arsenic exposure impairs myogenic differentiation. The purpose of this study was to use Fundulus heteroclitus or killifish as a model organism to determine if embryonic-only arsenic exposure permanently reduces the number or function of muscle satellite cells. Killifish embryos were exposed to 0, 50, 200, or 800 ppb arsenite (AsIII ) until hatching, and then juvenile fish were raised in clean water...
March 19, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29564513/molecular-and-histomorphological-evaluation-of-female-rats-urethral-tissues-after-an-innovative-trauma-model-of-prolonged-vaginal-distention-immediate-short-term-and-long-term-effects
#10
Maria A T Bortolini, Suellen M Feitosa, Andreisa P M Bilhar, Gisela G R Salerno, Edmar Zanoteli, Manuel J Simões, Rodrigo A Castro
INTRODUCTION AND HYPOTHESIS: An animal model of vaginal distention (VD) was developed to reproduce the acute urethral injury and deficiency underlying stress urinary incontinence (SUI). Data on the chronic effects of urethral trauma and the recovery process are still scarce. We investigated acute, short- and long-term histomorphological and molecular changes in the urethra of rats post 12-h intermittent VD. METHODS: We evaluated the urethra of four groups of female rats (n = 72): control without trauma, 1 h, 7 days and 30 days post VD...
March 21, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29562315/the-protective-effect-of-melatonin-against-age-associated-sarcopenia-dependent-tubular-aggregates-formation-lactate-depletion-and-mitochondrial-changes
#11
Ramy K A Sayed, Marisol Fernández-Ortiz, María E Diaz-Casado, Iryna Rusanova, Ibtissem Rahim, Germaine Escames, Luis C López, Doaa M Mokhtar, Darío Acuña-Castroviejo
To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild type C57BL/6J female mice, were examined by magnetic resonance and microscopy. Locomotor activity, lactate production and nuclear apoptosis were also assessed. The results support the early onset of sarcopenia at 12 months of age, with reduction of muscle fibers' number, muscle weight/body weight ratio, lactate, and locomotor activity...
March 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29561896/the-dual-ccr2-ccr5-chemokine-receptor-antagonist-cenicriviroc-reduces-macrophage-infiltration-and-disease-severity-in-duchenne-muscular-dystrophy-dmdmdx-4cv-mice
#12
Feng Liang, Christian Giordano, Dong Shang, Qian Li, Basil J Petrof
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness which is ultimately fatal, most often due to involvement of the diaphragm. Macrophage infiltration of dystrophic muscles has been strongly linked to muscle damage and fibrosis in DMD. We hypothesized that cenicriviroc (CVC), a dual chemokine receptor (CCR2/CCR5) antagonist currently under clinical evaluation for other diseases, could prevent macrophage accumulation and blunt disease progression in the diaphragms of mdx mice (genetic homologue of DMD)...
2018: PloS One
https://www.readbyqxmd.com/read/29558930/downregulation-of-the-nlrp3-inflammasome-by-adiponectin-rescues-duchenne-muscular-dystrophy
#13
Raphaël Boursereau, Michel Abou-Samra, Sophie Lecompte, Laurence Noel, Sonia M Brichard
BACKGROUND: The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant activation leads to several inflammatory or immune diseases. Here we investigated the expression of the NLRP inflammasome in skeletal muscle and its contribution to DMD...
March 20, 2018: BMC Biology
https://www.readbyqxmd.com/read/29557512/-infantile-convulsions-in-the-early-nineteenth-century-abnormal-brain-blood-flow-and-leeches-teething-and-gums-scarification-and-food-and-purgatives-the-historical-contribution-of-john-clarke-1760-1815
#14
EDITORIAL
Francesco Brigo, Simona Lattanzi, Eugen Trinka, Raffaele Nardone, Nicola Luigi Bragazzi, Martino Ruggieri, Ignazio Vecchio, Mariano Martini
In this article, we discuss on the role of the British physician and midwifery practitioner John Clarke (1760-1815) in the characterisation of the various types of seizures and epilepsy and related phenomena ('convulsions') occurring in children. In his unfinished work Commentaries on Some of the Most Important Diseases of Children (1815), Clarke discussed the pathophysiology of convulsions and was the first to describe, 12 years before the French neurologist Louis Francois Bravais (1801-1843) and more than 30 years before the Irish-born physician Robert Bentley Todd (1809-1860), the postictal paresis...
March 20, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29526991/protective-effects-of-astaxanthin-on-a-combination-of-d-%C3%A2-galactose-and-jet-lag-induced-aging-model-in-mice
#15
Yinhua Ni, Tao Wu, Luna Yang, Yang Xu, Tsuguhito Ota, Zhengwei Fu
Oxidative stress caused free radical and mitochondrial damage plays a critical role in the progression of aging and age-related damage at the cellular and tissue levels. Antioxidant supplementation has received growing attention and the effects of antioxidant on aging are increasingly assessed in both animal and human studies. However, additional and more promising treatments that contribute to the expansion of anti-aging therapies are needed. Astaxanthin, a super antioxidant carotenoid and free radical scavenger, inhibits lipid peroxidation more potently than vitamin E...
March 10, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29504836/changes-in-physiological-and-performance-variables-in-non-professional-triathletes-after-taking-part-in-an-olympic-distance-triathlon
#16
Guillermo Olcina, Rafael Timón, Javier Brazo-Sayavera, Ismael Martínez-Guardado, Marta Marcos-Serrano, Carmen Crespo
Given increasing popularity of triathlon, the objective of this study was to evaluate the acute effects upon the health of triathletes. To do so, with a sample of 23 male athletes (34.4 ± 7.9 years old), an assessment was carried out both before and after an Olympic distance triathlon, of the bodily composition, the jumping ability and the BORG and VAS scales, as well as a blood analysis of the following: Lactate (mmol/L), Hematrocrit (%), Glucose (mg/dL), Total proteins (mg/dL), Triglycerides (mg/dL), Bilirubin (mg/dL), GOT (IU/L), GPT (IU/L), LDH (IU/L), CPK (IU/L)...
March 5, 2018: Research in Sports Medicine
https://www.readbyqxmd.com/read/29504090/some-peculiarities-of-local-distribution-of-multipotent-mesenchymal-stromal-cells-after-their-injection-into-intact-muscle-tissue-in-experiment
#17
I V Maiborodin, V V Morozov, A A Anikeev, R V Maslov, N F Figurenko, V A Matveeva, V I Maiborodina
Changes in the muscular tissue after subcutaneous injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and additionally stained with cell membrane dye Vybrant CM-Dil in the projection of ligated femoral vein were studied by light microscopy with luminescence. Stromal cells injected through the skin can appear not only in the damaged tissue where acceleration of regeneration processes is required, but also in intact structures located in superficial or deeper layers...
March 4, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29475207/the-impact-of-soccer-match-play-on-the-muscle-damage-response-in-youth-female-athletes
#18
Jonathan D Hughes, Katrina Denton, Rhodri S Lloyd, Jon L Oliver, Mark De Ste Croix
Post-match assessment of creatine kinase (CK) activity and delayed-onset muscle soreness (DOMS) are common markers of exercise-induced muscle damage and recovery status in soccer players. These responses have not been examined in youth female players. This study examined the effect of competitive match play on CK activity and DOMS in elite youth players. Thirty-four elite female players, divided into three chronological age groups (U13, n=11; U15, n=10; U17 n=12). Players completed baseline testing for CK and DOMS that was repeated immediately (for DOMS), 80, 128 and 168 h post-competitive match play for CK...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29467464/loss-of-the-drosophila-m-aaa-mitochondrial-protease-paraplegin-results-in-mitochondrial-dysfunction-shortened-lifespan-and-neuronal-and-muscular-degeneration
#19
Gautam Pareek, Ruth E Thomas, Leo J Pallanck
The progressive accumulation of dysfunctional mitochondria is implicated in aging and in common diseases of the elderly. To oppose this occurrence, organisms employ a variety of strategies, including the selective degradation of oxidatively damaged and misfolded mitochondrial proteins. Genetic studies in yeast indicate that the ATPase Associated with diverse cellular Activities (AAA+ ) family of mitochondrial proteases account for a substantial fraction of this protein degradation, but their metazoan counterparts have been little studied, despite the fact that mutations in the genes encoding these proteases cause a variety of human diseases...
February 21, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29461420/the-effect-of-ibuprofen-on-muscle-hematological-and-renal-function-hydric-balance-pain-and-performance-during-intense-long-distance-running
#20
Raphael Fabricio de Souza, Dihogo Gama de Matos, Alexandre Reis Pires Ferreira, Philip Chilibeck, Natalie de Almeida Barros, Alan Santos de Oliveira, Luana Mendonça Cercato, Danielle Soares da Silva, Felipe José Aidar
The aim of this study was to investigate the effect of prophylactic use of nonsteroidal anti-inflammatory drugs (NSAID, i.e. Ibuprofen) on physical performance, vertical jump, muscle biomarkers, liver, kidney, acute pain and hydration status of participants in the 42 km Trail Running Challenge, a long-distance race integrated over mountain routes. The sample consisted of 20 males randomly divided into two groups: a control group (CG) and an experimental group (EG) with 12 completing the race (41.1±8.8 y; 75...
February 14, 2018: Journal of Strength and Conditioning Research
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