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https://www.readbyqxmd.com/read/28527229/effects-of-interactive-metronome-training-on-upper-extremity-function-adl-and-qol-in-stroke-patients
#1
Ga-Hui Yu, Jae-Shin Lee, Su-Kyoung Kim, Tae-Hyun Cha
BACKGROUND: Rhythm and timing training is stimulation that substitutes for a damaged function controls muscular movement or temporal element, which has positive impacts on the neurological aspect and movement of the brain. OBJECTIVE: This study is to assess the changes caused by rhythm and timing training using an interactive metronome (IM) on upper extremity function, ADL and QOL in stroke patients. METHODS: In order to assess the effects of IM training, a group experiment was conducted on 30 stroke patients...
May 19, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28526870/time-course-responses-of-circulating-micrornas-to-three-resistance-training-protocols-in-healthy-young-men
#2
Shufang Cui, Biao Sun, Xin Yin, Xia Guo, Dingming Chao, Chunni Zhang, Chen-Yu Zhang, Xi Chen, Jizheng Ma
Circulating microRNAs (c-miRNAs) in human plasma have been described as a potential marker of exercise. The present study investigated the effects of three acute resistance training (RT) protocols on the time-course changes of the c-miRNAs profiles in young males. The subjects (n = 45) were randomly divided into three groups: muscular strength endurance (SE), muscular hypertrophy (MH) and maximum strength (MS). Venous blood samples were obtained before exercise and immediately, 1 h and 24 h after each RT protocol to assess the following biological parameters: c-miRNAs, anabolic and catabolic hormones, inflammatory cytokines and muscle damage markers...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28520806/als-skeletal-muscle-shows-enhanced-tgf-%C3%AE-signaling-fibrosis-and-induction-of-fibro-adipogenic-progenitor-markers
#3
David Gonzalez, Osvaldo Contreras, Daniela L Rebolledo, Juan Pablo Espinoza, Brigitte van Zundert, Enrique Brandan
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motoneurons degenerate leading to muscle wasting, paralysis and eventually death from respiratory failure. Several studies indicate that skeletal muscle contributes to disease progression; however the molecular mechanisms remain elusive. Fibrosis is a common feature in skeletal muscle under chronic damage conditions such as those caused by muscular dystrophies or denervation. However, the exact mechanisms of fibrosis induction and the cellular bases of this pathological response are unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28512793/5-azacytidine-mediated-hmsc-behaviour-on-electrospun-scaffolds-for-skeletal-muscle-regeneration
#4
Ines Fasolino, Vincenzo Guarino, Valentina Cirillo, Luigi Ambrosio
Incomplete regeneration after trauma or muscular dysfunction is a common problem in muscle replacement therapies. Recent approaches in tissue engineering allow for the replication of skeletal muscle structure and function in vitro and in vivo by molecular therapies and implantable scaffolds which properly address muscle cells towards myotube differentiation and maturation. Here, we investigate the in vitro response of human Mesenchymal Stem Cells (hMSC) on electrospun fibres made of Polycaprolactone (PCL) in the presence of 5-azacytidine (5-AZA) to evaluate how fibrous network may influence the therapeutic effect of drug during in vitro myogenesis...
May 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28503323/severe-cervical-flexion-myelopathy-with-long-tract-signs-a-case-report-and-a-review-of-literature
#5
Takahito Fujimori, Akiko Tamura, Toshitada Miwa, Motoki Iwasaki, Takenori Oda
INTRODUCTION: Hirayama disease, a type of cervical flexion myelopathy, is a rare neurological disease characterized by muscular atrophy of the forearms and hands. Generally, the pathology is limited to the gray matter of the anterior horns in the lower cervical spinal cord. However, in rare cases the damage can spread to the white matter and present as long tract signs. CASE PRESENTATION: We report on a 30-year-old female whose onset presented as unilateral muscle atrophy of the right hand in her teens...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28493972/positive-radionuclide-imaging-of-mirna-expression-using-riles-and-the-human-sodium-iodide-symporter-as-reporter-gene-is-feasible-and-supports-a-protective-role-of-mirna-23a-in-response-to-muscular-atrophy
#6
Viorel Simion, Julien Sobilo, Rudy Clemoncon, Sharuja Natkunarajah, Safia Ezzine, Florence Abdallah, Stephanie Lerondel, Chantal Pichon, Patrick Baril
MicroRNAs (miRNAs) are key players in many biological processes and are considered as an emerging class of pharmacology drugs for diagnosis and therapy. However to fully exploit the therapeutic potential of miRNAs, it is becoming crucial to monitor their expression pattern using medical imaging modalities. Recently, we developed a method called RILES, for RNAi-Inducible Luciferase Expression System that relies on an engineered regulatable expression system to switch-ON the expression of the luciferase gene when a miRNA of interest is expressed in cells...
2017: PloS One
https://www.readbyqxmd.com/read/28483381/brains-and-brawn-toxoplasma-infections-of-the-central-nervous-system-and-skeletal-muscle
#7
REVIEW
Elizabeth A Wohlfert, Ira J Blader, Emma H Wilson
Toxoplasma gondii is a widespread parasitic pathogen that infects over a third of the world's population. Following an acute infection, the parasite can persist within its mammalian host as intraneuronal or intramuscular cysts. Cysts will occasionally reactivate, and - depending on the host's immune status and site of reactivation - encephalitis or myositis can develop. Because these diseases have high levels of morbidity and can be lethal, it is important to understand how Toxoplasma traffics to these tissues, how the immune response controls parasite burden and contributes to tissue damage, and what mechanisms underlie neurological and muscular pathologies that toxoplasmosis patients present with...
May 5, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28481856/systematic-review-of-animal-models-used-in-research-of-origins-and-treatments-of-fecal-incontinence
#8
Judith Evers, James F X Jones, P Ronan O'Connell
BACKGROUND: Fecal incontinence is a common disorder, but its pathophysiology is not completely understood. OBJECTIVE: The aim of this review is to present animal models that have a place in the study of fecal incontinence. DATA SOURCES: A literature review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines performed in August 2016 revealed 50 articles of interest. Search terms included fecal/faecal incontinence and animal model or specific species...
June 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28475846/resistance-exercise-attenuates-skeletal-muscle-oxidative-stress-systemic-pro-inflammatory-state-and-cachexia-in-walker-256-tumor-bearing-rats
#9
Camila Souza Padilha, Fernando H Borges, Lilian Eslaine Costa Mendes da Silva, Fernando Tadeu Trevisan Frajacomo, Alceu Afonso Jordao, José Alberto Duarte, Rubens Cecchini, Flávia Alessandra Guarnier, Rafael Deminice
The aim of this study was to investigate the effects of resistance exercise training (RET) on oxidative stress, systemic inflammatory markers and muscle wasting in Walker-256 tumor-bearing rats. Male (Wistar) rats were divided into 4 groups: sedentary controls (n=9); tumor-bearing (n=9); exercised (n=9); and tumor-bearing exercised (n=10). Exercised and tumor-bearing exercised rats were exposed to resistance exercise of climbing a ladder apparatus with weights tied to their tails during 6-wks. The physical activity of control and tumor-bearing rats was confined to the space of the cage...
May 5, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28474077/-the-impact-of-personality-traits-on-adolescents-adaptation-and-compliance-to-clear-retainers
#10
Fan Xu, Guo-Hua Tang
PURPOSE: The aim of this study was to evaluate the adolescents' adaptation and compliance to clear retainers, and to investigate their associations with personality traits. METHODS: Fifty adolescents at the end of fixed orthodontic treatment were consecutively recruited. After debonding the fixed orthodontic appliances, clear retainers were used. Participants were asked to fill questionnaires 2 months after wearing the clear retainers. A questionnaire was designed to evaluate their adaptation and compliance for clear retianers...
February 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28472288/oxidative-stress-in-duchenne-muscular-dystrophy-focus-on-the-nrf2-redox-pathway
#11
Sara Petrillo, Laura Pelosi, Fiorella Piemonte, Lorena Travaglini, Laura Forcina, Michela Catteruccia, Stefania Petrini, Margherita Verardo, Adele D'Amico, Antonio Musarò, Enrico Bertini
Oxidative stress is involved in the pathogenesis of Duchenne muscular dystrophy (DMD), an X-linked genetic disorder caused by mutations in the dystrophin gene and characterized by progressive, lethal muscle degeneration and chronic inflammation. In this study, we explored the expression and signaling pathway of a master player of the anti-oxidant and anti-inflammatory response, namely NRF2, in muscle biopsies of DMD patients. We classified DMD patients in two age groups (Class I, 0-2 years and Class II, 2-9 years), in order to evaluate the antioxidant pathway expression during the disease progression...
May 3, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28470591/high-intensity-interval-training-in-facioscapulohumeral-muscular-dystrophy-type-1-a-randomized-clinical-trial
#12
Grete Andersen, Karen Heje, Astrid Emile Buch, John Vissing
Increasing evidence suggests that high-intensity training (HIT) is a time-efficient exercise strategy to improve fitness. HIT has never been explored in neuromuscular diseases, likely because it may seem counterintuitive. A single session of high-intensity exercise has been studied without signs of muscle damage in facioscapulohumeral muscular dystrophy type 1 (FSHD1). We aimed to determine whether HIT is safe and effective in FSHD1 in a randomized, controlled parallel study. Untrained adults with genetically verified FSHD1 (n = 13) able to perform cycle-ergometer exercise were randomized to 8 weeks of supervised HIT (n = 6) (3 × 10-min cycle-ergometer-HIT/week) or 8 weeks of usual care (n = 7)...
May 3, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28463682/potential-therapeutic-action-of-adiponectin-in-duchenne-muscular-dystrophy
#13
Michel Abou-Samra, Raphaël Boursereau, Sophie Lecompte, Laurence Noel, Sonia M Brichard
Adiponectin (ApN) is a hormone that exhibits anti-inflammatory effects on skeletal muscle exposed to acute and chronic inflammation. We have previously tested the implication of ApN in Duchenne muscular dystrophy (DMD) using mdx mice, a model of DMD, and by generating transgenic mdx mice overexpressing ApN. We showed that ApN can act as a preventive agent and delay disease progression by reducing muscle inflammation/injury and improving force/myogenesis. Herein, we took an opposite approach and crossed mdx mice with ApN knockout mice, to obtain mdx mice with ApN depletion...
April 29, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28461862/effectiveness-of-coenzyme-q10-on-echocardiographic-parameters-of-patients-with-duchenne-muscular-dystrophy
#14
Forod Salehi, Aliakbar Zeinaloo, Hamid Reza Riasi, Alireza Sepehri Shamloo
BACKGROUND: Myocardial damage is a common complication in patients with Duchenne muscular dystrophy (DMD) that occurs due to myocardial replacement by fat and fibrosis. In recent years, efforts have been made toward finding new pharmacological agents with fewer complications which can be used as prophylactic before the symptoms. Coenzyme Q10 plays a central role in production of bioenergy in heart muscle and antioxidant in reperfusion condition of myocardial damaged muscle and leads to membrane stability and prevents cell death...
March 2017: Electronic Physician
https://www.readbyqxmd.com/read/28456937/muscle-microdialysis-to-investigate-inflammatory-biomarkers-in-facioscapulohumeral-muscular-dystrophy
#15
Giorgio Tasca, Mauro Monforte, Maddalena Corbi, Giuseppe Granata, Donatella Lucchetti, Alessandro Sgambato, Enzo Ricci
Recent progresses in the understanding of facioscapulohumeral muscular dystrophy (FSHD) genetics opened the way to the development of targeted therapies. However, knowledge about pathophysiology of muscle damage is still limited and there is increasing need to identify biomarkers of disease activity in the perspective of clinical trial readiness.We analyzed inflammatory mediators in the interstitial fluid of muscles with different MRI signal in FSHD patients, comparing muscles displaying early lesions on short-tau inversion recovery (STIR) sequences with normal ones...
April 29, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28446779/functional-neuronal-differentiation-of-injury-induced-muscle-derived-stem-cell-like-cells-with-therapeutic-implications
#16
Kinga Vojnits, Haiying Pan, Xiaojing Dai, Hao Sun, Qingchun Tong, Radbod Darabi, Johnny Huard, Yong Li
Mammalian skeletal muscles contain a number of heterogeneous cell populations. Our previous study characterized a unique population of myogenic lineage stem cells that can be isolated from adult mammalian skeletal muscles upon injury. These injury-induced muscle-derived stem cell-like cells (iMuSCs) displayed a multipotent state with sensitiveness and strong migration abilities. Here, we report that these iMuSCs have the capability to form neurospheres that represent multiple neural phenotypes. The induced neuronal cells expressed various neuron-specific proteins, their mRNA expression during neuronal differentiation recapitulated embryonic neurogenesis, they generated action potentials, and they formed functional synapses in vitro...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28445518/use-of-human-fat-grafting-in-the-prevention-of-perineural-adherence-experimental-study-in-athymic-mouse
#17
Mario Cherubino, Igor Pellegatta, Alessandro Crosio, Luigi Valdatta, Stefano Geuna, Rosalba Gornati, Pierluigi Tos
Perineural adherences represent a problem after surgery involving peripheral neural system. Fat-grafting with adipose derived stem cells (ASCs) with their pro-regenerative characteristics can be important to prevent the neural damage or to facilitate the neural regeneration. Our idea was to use the fat-grafting as an anti-adherence device and test its efficacy on a postsurgical scar animal model and comparing to an antiadhesive gel. 32 athymic mice were operated under magnification, we exposed both sciatic nerves...
2017: PloS One
https://www.readbyqxmd.com/read/28444416/control-of-dna-integrity-in-skeletal-muscle-under-physiological-and-pathological-conditions
#18
REVIEW
Yara Bou Saada, Vlada Zakharova, Boris Chernyak, Carla Dib, Gilles Carnac, Svetlana Dokudovskaya, Yegor S Vassetzky
Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health...
April 25, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28444094/jumping-in-aquatic-environment-after-sciatic-nerve-compression-nociceptive-evaluation-and-morphological-characteristics-of-the-soleus-muscle-of-wistar-rats
#19
Jéssica Aline Malanotte, Camila Mayumi Martin Kakihata, Jhenifer Karvat, Rose Meire Costa Brancalhão, Lucinéia de Fátima Chasko Ribeiro, Gladson Ricardo Flor Bertolini
Objective: To evaluate the effect of jumping in aquatic environment on nociception and in the soleus muscle of trained and not trained Wistar rats, in the treatment of compressive neuropathy of the sciatic nerve. Methods: Twenty-five Wistar rats were distributed into five groups: Control, Lesion, Trained + Lesion, Lesion + Exercise, and Trained + Lesion + Exercise. The training was jumping exercise in water environment for 20 days prior to injury, and treatment after the injury...
January 2017: Einstein
https://www.readbyqxmd.com/read/28440464/proteomic-profiling-of-mdx-4cv-serum-reveals-highly-elevated-levels-of-the-inflammation-induced-plasma-marker-haptoglobin-in-muscular-dystrophy
#20
Sandra Murphy, Paul Dowling, Margit Zweyer, Michael Henry, Paula Meleady, Rustam R Mundegar, Dieter Swandulla, Kay Ohlendieck
X-linked muscular dystrophy is caused by primary abnormalities in the Dmd gene and is characterized by the almost complete loss of the membrane cytoskeletal protein dystrophin, which triggers sarcolemmal instability, abnormal calcium homeostasis, increased proteolysis and impaired excitation‑contraction coupling. In addition to progressive necrosis, crucial secondary pathologies are represented by myofibrosis and the invasion of immune cells in damaged muscle fibres. In order to determine whether these substantial changes within the skeletal musculature are reflected by an altered rate of protein release into the circulatory system or other plasma fluctuations, we used label‑free mass spectrometry to characterize serum from the mdx‑4cv model of Duchenne muscular dystrophy...
June 2017: International Journal of Molecular Medicine
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