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https://www.readbyqxmd.com/read/29236801/effect-of-atenolol-pre-treatment-in-heart-damage-in-a-model-of-intestinal-ischemia-reperfusion
#1
Mieko Okada, Luiz Fernando Reis Falcão, David Ferez, José Luiz Martins, Paolo Ruggero Errante, Francisco Sandro Menezes Rodrigues, Afonso Caricati-Neto, Márcia Marinho, Guilherme Fenelon, Itamar Souza
PURPOSE: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. METHODS: Adult Wistar male rats were randomly (n=8), anesthetized and divided in: Sham: submitted to operation only; group SS+IR: intravenous saline infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); group AT+IR: intravenous atenolol infusion (2 mg/kg) following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); and group AT+I+AT+R: intravenous atenolol infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and in the time 45 minutes other atenolol doses were administrated and the artery was open for 120 minutes (reperfusion), all animals were submitted to muscular relaxation for mechanical ventilation...
November 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29232836/spasticity-management-in-disorders-of-consciousness
#2
REVIEW
Géraldine Martens, Steven Laureys, Aurore Thibaut
Background: Spasticity is a motor disorder frequently encountered after a lesion involving the central nervous system. It is hypothesized to arise from an anarchic reorganization of the pyramidal and parapyramidal fibers and leads to hypertonia and hyperreflexia of the affected muscular groups. While this symptom and its management is well-known in patients suffering from stroke, multiple sclerosis or spinal cord lesion, little is known regarding its appropriate management in patients presenting disorders of consciousness after brain damage...
December 9, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29222849/bone-marrow-transplantation-improves-motor-activity-in-a-mouse-model-of-ataxia
#3
David Díaz, Marina Piquer-Gil, Javier Sánchez Recio, María Magdalena Martínez-Losa, José Ramón Alonso, Eduardo Weruaga, Manuel Álvarez-Dolado
Ataxias are locomotor disorders that can have an origin both neural and muscular, although both impairments are related. Unfortunately, ataxia has no cure and the current therapies are aimed at motor re-education or muscular reinforcement. Nevertheless, cell therapy is becoming a promising approach to deal with incurable neural diseases, including neuro-muscular ataxias. Here we have used a model of ataxia, the PCD mutant mouse, to study the effect of healthy (wild-type) bone marrow transplantation on the restoration of defective mobility...
December 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29222416/functional-analysis-of-human-intrafusal-fiber-innervation-by-human-%C3%AE-motoneurons
#4
A Colón, X Guo, N Akanda, Y Cai, J J Hickman
Investigation of neuromuscular deficits and diseases such as SMA, as well as for next generation prosthetics, utilizing in vitro phenotypic models would benefit from the development of a functional neuromuscular reflex arc. The neuromuscular reflex arc is the system that integrates the proprioceptive information for muscle length and activity (sensory afferent), to modify motoneuron output to achieve graded muscle contraction (actuation efferent). The sensory portion of the arc is composed of proprioceptive sensory neurons and the muscle spindle, which is embedded in the muscle tissue and composed of intrafusal fibers...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29215066/pharmacological-inhibition-of-rev-erb-stimulates-differentiation-inhibits-turnover-and-reduces-fibrosis-in-dystrophic-muscle
#5
Ryan D Welch, Cyrielle Billon, Aurore-Cecile Valfort, Thomas P Burris, Colin A Flaveny
Duchenne muscular dystrophy (DMD) is a debilitating X-linked disorder that is fatal. DMD patients lack the expression of the structural protein dystrophin caused by mutations within the DMD gene. The absence of functional dystrophin protein results in excessive damage from normal muscle use due to the compromised structural integrity of the dystrophin associated glycoprotein complex. As a result, DMD patients exhibit ongoing cycles of muscle destruction and regeneration that promote inflammation, fibrosis, mitochondrial dysfunction, satellite cell (SC) exhaustion and loss of skeletal and cardiac muscle function...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214629/targeting-early-pkc%C3%AE-dependent-t-cell-infiltration-of-dystrophic-muscle-reduces-disease-severity-in-a-mouse-model-of-muscular-dystrophy
#6
Biliana Lozanoska-Ochser, Anna Benedetti, Giuseppe Rizzo, Valeria Marrocco, Rosanna Di Maggio, Piera Fiore, Marina Bouche
Chronic muscle inflammation is a critical feature of Duchenne muscular dystrophy and contributes to muscle fibre injury and disease progression. Although previous studies have implicated T cells in the development of muscle fibrosis, little is known about their role during the early stages of muscular dystrophy. Here, we show that T cells are among the first cells to infiltrate mdx mouse dystrophic muscle, prior to the onset of necrosis, suggesting an important role in early disease pathogenesis. Based on our comprehensive analysis of the kinetics of the immune response, we further identify the early pre-necrotic stage of muscular dystrophy as the relevant time frame for T cell-based interventions...
December 7, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29208475/cortical-bone-trajectory-screws-fixation-in-lumbar-adjacent-segment-disease-a-technique-note-with-case-series
#7
Chao-Hsuan Chen, Hsieng-Ming Huang, Der-Cherng Chen, Chih-Ying Wu, Han-Chun Lee, Der-Yang Cho
Lumbar adjacent segment disease after lumbar fusion surgery often requires surgical intervention. However, subsequent surgical treatment often needs to expose and remove all of the previous instruments. This additional surgery leads to significant post-operative pain, muscular fibrosis, poor wound healing and infection, etc. From October 2015 to March 2016, we collected six cases underwent cortical bone trajectory screws fixation with minimal invasive inter-body cage fusion for lumbar adjacent segment disease...
December 2, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29203713/therapeutic-potential-of-heat-shock-protein-induction-for-muscular-dystrophy-and-other-muscle-wasting-conditions
#8
REVIEW
Savant S Thakur, Kristy Swiderski, James G Ryall, Gordon S Lynch
Duchenne muscular dystrophy is the most common and severe of the muscular dystrophies, a group of inherited myopathies caused by different genetic mutations leading to aberrant expression or complete absence of cytoskeletal proteins. Dystrophic muscles are prone to injury, and regenerate poorly after damage. Remorseless cycles of muscle fibre breakdown and incomplete repair lead to progressive and severe muscle wasting, weakness and premature death. Many other conditions are similarly characterized by muscle wasting, including sarcopenia, cancer cachexia, sepsis, denervation, burns, and chronic obstructive pulmonary disease...
January 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29203220/bilateral-spontaneous-anterior-shoulder-dislocation-a-missed-orthopedic-injury-mistaken-as-proximal-neuropathy
#9
Khalil Ahmad, Saeed Bin Ayaz, Heyyan Bin Khalil, Sumeera Matee
A number of orthopedic injuries can occur during epileptic seizures. Anterior shoulder dislocation is one such orthopedic injury that is quite rare. The shoulder dislocation may injure the brachial plexus. Besides seizures, the nerves can also be damaged by anticonvulsive therapy. Muscle wasting following a seizure can misguide a clinician to investigate only neural or muscular pathologies. We report here an individual with epilepsy who was referred to us for electrodiagnostic evaluation of proximal muscle wasting related to a suspected proximal neuropathy...
November 4, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29199551/royal-sun-culinary-medicinal-mushroom-agaricus-brasiliensis-agaricomycetes-supplement-in-training-capacity-improvement-parameters
#10
Flávio F Silva, Guilherme A C de Oliveira, Hugo C Martins Costa, Wiliam C B Regis
People seek a greater quality of life and healthy aging that culminates in improved self-esteem and vitality in the performance of daily activities; this is generating a growing number of people enrolled in gyms in search of quick results. However, this training can result in physical and metabolic damage. During physical exercise, under conditions of oxidative stress, changes take place that lead to the onset of fatigue. The Agaricus brasiliensis mushroom is native to Brazil and has therapeutic potential, with widely studied antioxidant and immunomodulatory capabilities...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29198019/muscle-proteolytic-system-modulation-through-the-effect-of-taurine-on-mice-bearing-muscular-atrophy
#11
Rania M Khalil, Walied S Abdo, Ahmed Saad, Eman G Khedr
Skeletal muscle atrophy occurs in different catabolic conditions and mostly accompanied with upregulation of Muscle ring finger 1 (MuRF1) gene which is one of the master regulatory genes in muscle atrophy. Taurine amino acid is widely distributed in different tissues and has anti-inflammatory and antioxidant effects. This study aimed to investigate the potential influence of taurine on muscle atrophy induced by reduced mechanical loading. Twenty-eight Albino mice were used, and divided equally into four groups: group I (control); group II (immobilization); group III (immobilization + taurine); and group IV (taurine)...
December 2, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29193255/evaluation-of-the-single-medial-circummuscular-perforator-diep-flap-outcomes-and-comparison-to-traditional-transmuscular-single-perforator-flap
#12
Jessica F Rose, Dmitry Zavlin, Amanda E Garrett, Vishwanath Chegireddy, Warren A Ellsworth
INTRODUCTION: Successful breast reconstruction using deep inferior epigastric perforator (DIEP) flaps depends on optimal perforator choice. Circummuscular wraparound medial perforators allow for no rectus dissection and minimal fascial incisions, often presenting as an ideal option. The aim of our study is to evaluate outcomes of the single medial wraparound perforator flap in comparison to more traditional transmuscular single-perforator DIEP flaps. PATIENTS AND METHODS: A retrospective chart review was conducted of all DIEP flaps performed by the senior author from 2011 to 2016, yielding 269 flaps on 157 patients...
November 29, 2017: Microsurgery
https://www.readbyqxmd.com/read/29188135/benefits-of-prenatal-taurine-supplementation-in-preventing-the-onset-of-acute-damage-in-the-mdx-mouse
#13
Robert G Barker, Deanna Horvath, Chris van der Poel, Robyn M Murphy
Introduction: Duchenne Muscular Dystrophy (DMD) is a debilitating muscle wasting disorder with no cure. Safer supplements and therapies are needed to improve the severity of symptoms, as severe side effects are associated with the only effective treatment, corticosteroids. The amino acid taurine has shown promise in ameliorating dystrophic symptoms in mdx mice, an animal model of DMD, however little work is in 21-28 (d)ay animals, the period of natural peak damage. Methods: This study compares the effect of prenatal taurine supplementation on tibialis anterior (TA) in situ contractile function, histopathological characteristics and the abundance of Ca2+-handling as well as pathologically relevant proteins in non-exercised mdx mice at 28 and 70 d...
September 22, 2017: PLoS Currents
https://www.readbyqxmd.com/read/29188128/influenza-a-virus-infection-damages-zebrafish-skeletal-muscle-and-exacerbates-disease-in-zebrafish-modeling-duchenne-muscular-dystrophy
#14
Michelle Goody, Denise Jurczyszak, Carol Kim, Clarissa Henry
INTRODUCTION: Both genetic and infectious diseases can result in skeletal muscle degeneration, inflammation, pain, and/or weakness. Duchenne muscular dystrophy (DMD) is the most common congenital muscle disease. DMD causes progressive muscle wasting due to mutations in Dystrophin. Influenza A and B viruses are frequently associated with muscle complications, especially in children. Infections activate an immune response and immunosuppressant drugs reduce DMD symptoms. These data suggest that the immune system may contribute to muscle pathology...
October 25, 2017: PLoS Currents
https://www.readbyqxmd.com/read/29184336/speech-signal-analysis-and-pattern-recognition-in-diagnosis-of-dysarthria
#15
Minu George Thoppil, C Santhosh Kumar, Anand Kumar, John Amose
Background: Dysarthria refers to a group of disorders resulting from disturbances in muscular control over the speech mechanism due to damage of central or peripheral nervous system. There is wide subjective variability in assessment of dysarthria between different clinicians. In our study, we tried to identify a pattern among types of dysarthria by acoustic analysis and to prevent intersubject variability. Objectives: (1) Pattern recognition among types of dysarthria with software tool and to compare with normal subjects...
October 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29183282/bilateral-muscle-fiber-and-nerve-influences-by-tnf-alpha-in-response-to-unilateral-muscle-overuse-studies-on-tnf-receptor-expressions
#16
Lina Renström, Per Stål, Yafeng Song, Sture Forsgren
BACKGROUND: TNF-alpha is suggested to be involved in muscle damage and muscle inflammation (myositis). In order to evaluate whether TNF-alpha is involved in the myositis that occurs in response to muscle overuse, the aim was to examine the expression patterns of TNF receptors in this condition. METHODS: A rabbit muscle overuse model leading to myositis in the soleus muscle was used. The expression patterns of the two TNF receptors Tumor Necrosis Factor Receptor type 1 (TNFR1) and Tumor Necrosis Factor Receptor type 2 (TNFR2) were investigated...
November 28, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29181643/vibrational-spectroscopy-of-muscular-tissue-intoxicated-by-snake-venom-and-exposed-to-photobiomodulation-therapy
#17
Willians Fernando Vieira, Bruno Kenzo-Kagawa, Maria Helena Mesquita Britto, Helder José Ceragioli, Kumiko Koibuchi Sakane, Vitor Baranauskas, Maria Alice da Cruz-Höfling
The pathogenesis of myonecrosis caused by myotoxins from bothropic venom is associated with local extracellular matrix (ECM) disintegration, hemorrhage, and inflammation. Search for alternative methods associated with serum therapy is mandatory to neutralize the fast development of local damage following snakebites. The experimental use of photobiomodulation therapy (PBMT) in murine models has shown promising results relative to structural and functional recovery from bothropic snakebite-induced myonecrosis...
November 28, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29177540/the-distance-of-the-gluteal-nerve-in-relation-to-anatomical-landmarks-an-anatomic-study
#18
David Putzer, Matthias Haselbacher, Romed Hörmann, Martin Thaler, Michael Nogler
INTRODUCTION: Gluteal insufficiency is of concern with lateral approaches to total hip arthroplasty. Damage to the branches of the superior gluteal nerve may cause degeneration of the innervated muscles. The direct anterior approach exploits the intermuscular and internerval interval between tensor fasciae latae laterally and sartorius and rectus femoris muscle medially. In this study, the distance of the superior gluteal nerve in relation to anatomical landmarks was determined. MATERIALS AND METHODS: Two experienced surgeons implanted trial components in 15 alcohol glycerol fixed cadavers with 30 hips...
November 25, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29176415/discussion-protective-effect-of-hydrogen-gas-inhalation-on-muscular-damage-using-a-mouse-hindlimb-ischemia-reperfusion-injury-model
#19
Indranil Sinha, Giorgio Giatsidis, Dennis P Orgill
No abstract text is available yet for this article.
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29175948/increased-non-hdl-cholesterol-levels-cause-muscle-wasting-and-ambulatory-dysfunction-in-the-mouse-model-of-lgmd2b
#20
Stephanie L Sellers, Nadia Milad, Zoe White, Chris D Pascoe, Rayleigh Chan, Geoffrey W Payne, Chun Y Seow, Fabio Rossi, Michael A Seidman, Pascal N Bernatchez
Progressive limb and girdle muscle atrophy leading to loss of ambulation is a hallmark of dysferlinopathies, which include limb-girdle muscular dystrophy type 2B and Miyoshi myopathy. However, animal models fail to fully reproduce the disease severity observed in humans, with Dysferlin-null (Dysf-/-) mice exhibiting minor muscle damage and weakness without dramatic ambulatory dysfunction. As we have previously reported significant Dysf expression in blood vessels, we investigated the role of vascular function in development of muscle pathology by generating a Dysf-deficient mouse model with vascular disease...
November 25, 2017: Journal of Lipid Research
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