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https://www.readbyqxmd.com/read/28094105/sonographic-alteration-of-substantia-nigra-is-related-to-parkinsonism-predominant-course-of-x-linked-dystonia-parkinsonism
#1
Uwe Walter, Raymond Rosales, Alessandro Rocco, Ana Westenberger, Aloysius Domingo, Criscely L Go, Norbert Brüggemann, Christine Klein, Lillian V Lee, Dirk Dressler
INTRODUCTION: X-linked recessive dystonia-parkinsonism (XDP, DYT3) is highly prevalent in the Philippines and manifests with varying phenotype. We sought to evaluate the significance of transcranial brain sonography as a biomarker for parkinsonism-predominant phenotype. METHODS: 90 Filipino participants were enrolled into a cross-sectional study: 39 patients with XDP, 21 asymptomatic first-degree relatives of XDP patients, and 30 healthy control subjects. Echogenicity of the substantia nigra and the lenticular nuclei was digitally quantified...
January 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28070965/the-consequences-of-avian-ocular-trauma-histopathological-evidence-and-implications-of-acute-and-chronic-disease
#2
Bret A Moore, Leandro B C Teixeira, William E Sponsel, Richard R Dubielzig
OBJECTIVE: To present a description and categorization of the histopathological lesions in avian ocular trauma. ANIMAL STUDIED: Seventy-five birds diagnosed with ocular trauma at to the Comparative Ocular Pathology Laboratory of Wisconsin. PROCEDURES: Histological slides were reviewed, and the type of trauma was classified by cause into either (i) blunt trauma or (ii) penetrating trauma and by duration into (i) acute or (ii) chronic. RESULTS: Blunt trauma was the most common source of trauma, and the most frequent lesions were observed in the retina (91%), with 71% of retinas having a tear or detachment and 46% of retinas showing chronic degenerative changes...
January 10, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28068443/possible-risk-factors-and-clinical-effects-of-opaque-bubble-layer-in-small-incision-lenticule-extraction-smile
#3
Gisung Son, Junghyun Lee, Cheolwon Jang, Ki Yong Choi, Beom Jin Cho, Tae Hyung Lim
PURPOSE: To report the development of an opaque bubble layer (OBL) during small incision lenticule extraction (SMILE) and analyze its potential risk factors and the clinical outcome. METHODS: A retrospective review of medical records was performed. The patients were divided into two groups in terms of OBL area following a posterior lenticule cut: OBL less than 5% of cornea and OBL greater than 5% of cornea. Preoperative parameters and clinical outcomes were compared...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28059382/improving-the-performance-of-an-electrowetting-lenticular-lens-array-by-using-a-thin-polycarbonate-chamber
#4
Junsik Lee, Junoh Kim, Cheoljoong Kim, Dooseub Shin, Gyohyun Koo, Jee Hoon Sim, Yong Hyub Won
In this paper, we used a thin polycarbonate (PC) chamber to improve the performance of an electrowetting lenticular lens array. The polycarbonate chamber changed the radius of curvature (ROC) of the oil acting as a lens, which increased the dioptric power of the liquid lens to 1666.7D. The increase in dioptric power required a reduction in the distance between the optical center of the lens and the display pixels under the chamber, which was accomplished by reducing the thickness of the chamber. The optimal thickness of the chamber was determined to be 0...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28044393/cataracts-in-the-norwegian-buhund-current-prevalence-and-characteristics
#5
Elin Kristiansen, Tobias Revold, Frode Lingaas, Kristina Narfström, Pia Bjerre Pedersen, Camilla Kielland, Stein Dahl, Ernst-Otto Ropstad
OBJECTIVE: To evaluate prevalence and characteristics of cataracts in the Norwegian Buhund breed 20 years after high reported prevalence of especially pulverulent nuclear cataracts (PNCs). ANIMALS STUDIED: Two hundred and fifty Norwegian Buhund dogs in Norway, Sweden, and Denmark (117 males and 133 females) with previously unknown eye health status were included. Forty-five dogs had multiple examinations (two to six times over a 6-year period). Median age was 4...
January 3, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27966834/outcomes-of-scleral-buckling-using-chandelier-endoillumination
#6
Yuntao Hu, Shancheng Si, Ke Xu, Huijin Chen, Liang Han, Xin Wang, Zhizhong Ma
PURPOSE: To report the results and complications of scleral buckling for the treatment of rhegmatogenous retinal detachment (RRD) using 25-gauge chandelier endoillumination. METHODS: A total of 61 patients (61 eyes) with RRD were treated with scleral buckling. For the sclera buckling procedure, a 25-gauge chandelier was inserted through the pars plana for intra-ocular illumination, and retinal tears were identified and treated with episcleral cryotherapy under surgical microscope...
December 14, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27930991/identification-of-phytoconstituents-and-in-vitro-evaluation-of-the-putative-anticataractogenic-effect-of-an-ethanolic-root-extract-of-leucas-aspera
#7
Mahalingam Sundararajan, Philip A Thomas, Karuppan Babyshalini, Pitchairaj Geraldine
Modern herbal medicine has played a significant role in treating oxidative stress and related complications. In the present investigation, gas chromatography-mass spectrometric analysis of ethanolic extracts of the leaf and of the root of Leucas aspera (L. aspera) (Willd.) Link separately showed the presence of various phytoconstituents; major components have already been reported to possess various biological, including antioxidant, activities. Of the two extracts analyzed, the root extract exhibited more potential antioxidant activity than did the leaf extract...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27919335/cataractogenesis-following-high-let-radiation-exposure
#8
Nobuyuki Hamada, Tatsuhiko Sato
Biological effectiveness of ionizing radiation differs with its linear energy transfer (LET) such that high-LET radiation is more effective for various biological endpoints than low-LET radiation. Human exposure to high-LET radiation occurs in cancer patients, nuclear workers, aviators, astronauts and other space travellers. From the radiation protection viewpoint, the ocular lens is among the most radiosensitive tissues in the body, and cataract (a clouding of the normally transparent lens) is classified as tissue reactions (formerly called nonstochastic or deterministic effects) with a threshold below which no effect would occur...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27916313/influence-of-the-flap-on-outcomes-in-corneal-refractive-surgery-with-femtosecond-laser-smile-vs-flex
#9
J L Alió, M El Bahrawy, A Angelov, D Ortiz, P Yébana
OBJECTIVE: To investigate the influence of creating a flap on the postoperative optical quality of the cornea in terms of predicted corneal curvature and Seidel aberrations after 2 modalities of femtosecond assisted corneal lenticule extraction laser for the correction of myopia and myopic astigmatism: The flapless procedure small incision lenticular extraction (SMILE) and the flap-based femtosecond lenticular extraction (FLEx). METHODS: The study is a prospective consecutive non-randomised comparative interventional case series including 64 eyes with myopic or myopic astigmatism refractive errors...
December 1, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27911425/-biometric-parameters-of-vitrectomized-eyes
#10
S V Asatryan, V K Surguch, S I Kharlap, T A Shchegoleva
AIM: To analyze changes in various biometric parameters after vitrectomy. MATERIAL AND METHODS: A total of 50 patients (50 eyes) were followed up. All of them underwent vitrectomy for idiopathic epiretinal fibrosis and macular hole. In addition to the standard ophthalmic examination, we performed a combined ultrasound study and ultrasound biomicroscopy before and after the surgery (at 2-3 weeks and 6 months). Variation statistics was applied to assess the results using the SPSS Statistica 20 software...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27885765/conversion-of-the-native-24-mer-ferritin-nanocage-into-its-non-native-16-mer-analogue-by-insertion-of-extra-amino-acid-residues
#11
Shengli Zhang, Jiachen Zang, Wenming Wang, Hai Chen, Xiaorong Zhang, Fudi Wang, Hongfei Wang, Guanghua Zhao
Protein assemblies with high symmetry are widely distributed in nature. Most efforts so far have focused on repurposing these protein assemblies, a strategy that is ultimately limited by the structures available. To overcome this limitation, methods for fabricating novel self-assembling proteins have received intensive interest. Herein, by reengineering the key subunit interfaces of native 24-mer protein cage with octahedral symmetry through amino acid residues insertion, we fabricated a 16-mer lenticular nanocage whose structure is unique among all known protein cages...
December 23, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27863741/shear-targeted-drug-delivery-to-stenotic-blood-vessels
#12
Mark Epshtein, Netanel Korin
In this review we focus on shear targeted drug delivery as a novel strategy to selectively deliver drugs to sites of vascular obstruction. We review the physics of stenotic (abnormally narrowed) blood vessels, while focusing mainly on the hemodynamics and transport phenomena at these sites. We then discuss how the local abnormal levels of shear stress, which can mechanically activate platelets, can be leveraged for localized drug delivery. We describe the development of Shear Activated Nano-particle Aggregates (SA-NPAs) that are designed to release and localize their nanoparticle drug carriers at sites of vascular stenosis...
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27843230/preclinical-cataract-masquerading-as-post-lasik-regression
#13
Rohit Shetty, Nikhil Negalur, Mathew Kurian, Rushad Shroff
The purpose of this case report is to bring forth a rare clinical scenario where preclinical cataract mimics post-LASIK regression and to describe the role of aberrometry in detecting higher order aberrations (HOAs) and early lens changes. A 36-year-old female presented with blurring of vision since 1 year after having undergone an uneventful LASIK surgery 3 years prior. Corneal topography and aberrometry were within normal limits. Although the lens was morphologically normal on slit lamp examination, increased HOAs and lenticular density were detected...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27821692/combining-footwear-with-public-health-iconography-to-prevent-soil-transmitted-helminth-infections
#14
Sarah B Paige, Sagan Friant, Lucie Clech, Carly Malavé, Catherine Kemigabo, Richard Obeti, Tony L Goldberg
Shoes are effective for blocking soil-transmitted helminths (STHs) that penetrate the skin. Unfortunately, shoe-wearing is uncommon in many areas where STHs are prevalent, in part because local populations are unaware of the health benefits of wearing shoes. This is especially true in low-literacy populations, where information dissemination through written m essages is not possible. We launched a public health intervention that combines a public health image with sandals. The image is a "lenticular image" that combines two alternating pictures to depict the efficacy of shoes for preventing STH infection...
November 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27810790/evaluation-of-decreased-uptake-of-18f-fluorodeoxyglucose-in-the-cerebral-cortex-of-patients-with-intracranial-non-hodgkin-s-lymphoma-lesions-through-pet-ct
#15
Qingbo Zhang, Tian Tian, Li Wang, Hongxia Qiu, Danming Li
BACKGROUND: This study aims to investigate whether basal ganglia can be utilised as reference for measuring ratios between standardised uptake values (SUV), namely, SUVmax and SUVmean, of 18F-fluoro-deoxyglucose (18F-FDG) uptake, in the ipsilateral cerebral cortex and basal ganglia of patients with non-Hodgkin's lymphoma lesions. METHODS: Fifty-three patients with pathologically confirmed highly metabolic non-Hodgkin's lymphoma were retrospectively analysed; these patients were subjected to treatment strategy and underwent positron emission tomography/computed tomography (PET/CT)...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27789327/chronic-administration-of-ethanol-leaf-extract-of-moringa-oleifera-lam-moringaceae-may-compromise-glycaemic-efficacy-of-sitagliptin-with-no-significant-effect-in-retinopathy-in-a-diabetic-rat-model
#16
Comfort Olurishe, Helen Kwanashie, Abdulkadiri Zezi, Nuhu Danjuma, Bisalla Mohammed
ETHNOPHARMACOLOGICAL RELEVANCE: Moringa oleifera Lam. (Moringaceae) has gained awareness for its antidiabetic effect, and is used as alternative therapy or concurrently with orthodox medicines such as sitagliptin in diabetes mellitus. This is without ascertaining the possibility of drug-herb interactions, which could either lead to enhanced antidiabetic efficacy, increased toxicity, or compromised glycaemic control with negative consequence in diabetic retinopathy. AIM OF THE STUDY: To investigate the effect, of sitagliptin (50mg/kg), Moringa oleifera (300mg/kg) leaf extract, and a combination of both on glycaemic control parameters, lenticular opacity and changes in retinal microvasculature in alloxan (150mg/kg i...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27770229/whole-brain-analysis-of-postmortem-density-changes-of-grey-and-white-matter-on-computed-tomography-by-statistical-parametric-mapping
#17
Yuichi Nishiyama, Hidekazu Kanayama, Hiroshi Mori, Keiji Tada, Yasushi Yamamoto, Takashi Katsube, Haruo Takeshita, Kazunori Kawakami, Hajime Kitagaki
OBJECTIVES: This study examined the usefulness of statistical parametric mapping (SPM) for investigating postmortem changes on brain computed tomography (CT). METHODS: This retrospective study included 128 patients (23 - 100 years old) without cerebral abnormalities who underwent unenhanced brain CT before and after death. The antemortem CT (AMCT) scans and postmortem CT (PMCT) scans were spatially normalized using our original brain CT template, and postmortem changes of CT values (in Hounsfield units; HU) were analysed by the SPM technique...
October 21, 2016: European Radiology
https://www.readbyqxmd.com/read/27744053/olmesartan-an-angiotensin-ii-receptor-blocker-inhibits-the-progression-of-cataract-formation-in-cadmium-chloride-induced-hypertensive-albino-rats
#18
Rajesh Choudhary, Surendra H Bodakhe
AIMS: Previously we found that cadmium chloride (CdCl2) exposure substantially elevates hypertension and potentiates cataract formation. In the present study, we investigated the protective effects of olmesartan, an angiotensin II receptor blocker against cataractogenesis in the CdCl2-induced hypertensive animal model. MAIN METHODS: Male Sprague-Dawley albino rats (150-180g) were randomly selected and assigned to four groups (n=6). Among the four groups, one group (normal) received 0...
December 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27728893/magnesium-taurate-prevents-cataractogenesis-via-restoration-of-lenticular-oxidative-damage-and-atpase-function-in-cadmium-chloride-induced-hypertensive-experimental-animals
#19
Rajesh Choudhary, Surendra H Bodakhe
Previously we found that hypertension potentiates the risk the cataractogenesis. In the present study, we investigated the protective effects of magnesium taurate (MgT) on hypertension and associated lenticular damages against cadmium chloride (CdCl2)-induced hypertensive animals. Male Sprague-Dawley albino rats (150-180g) were assigned to five experimental groups (n=6). Among the five groups, normal group received 0.3% carboxymethyl cellulose (10ml/kg/day, p.o.). Hypertension control group received CdCl2 (0...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27721986/a-combination-of-intrastromal-and-intracameral-injections-of-amphotericin-b-in-the-treatment-of-severe-fungal-keratitis
#20
Jianzhang Hu, Jingjin Zhang, Yanling Li, Xiaoli Han, Weidong Zheng, Juan Yang, Guoxing Xu
Purpose. To evaluate the efficacy of a combination of intrastromal and intracameral injections of amphotericin B in the treatment of severe recalcitrant fungal keratitis. Methods. Patients with severe fungal keratitis who were resistant to conventional antifungal medical treatments and needed potential surgical intervention were recruited at the First Affiliated Hospital of Fujian Medical University between January 2012 and July 2013. The patients were treated with a combination of intrastromal and intracameral injections of amphotericin B (25 μg/mL and 50 μg/mL, resp...
2016: Journal of Ophthalmology
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