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https://www.readbyqxmd.com/read/27899371/refractive-improvements-and-safety-with-topography-guided-corneal-crosslinking-for-keratoconus-1-year-results
#1
Maria Nordström, Maria Schiller, Anneli Fredriksson, Anders Behndig
PURPOSE: To assess the refractive improvements and the corneal endothelial safety of an individualised topography-guided regimen for corneal crosslinking in progressive keratoconus. METHODS: An open-label prospective randomised clinical trial was performed at the Department of Clinical Sciences, Ophthalmology, Umeå University Hospital, Umeå, Sweden. Thirty-seven patients (50 eyes) with progressive keratoconus planned for corneal crosslinking were included. The patients were randomised to topography-guided crosslinking (photorefractive intrastromal crosslinking (PiXL); n=25) or uniform 9 mm crosslinking (corneal collagen crosslinking (CXL); n=25)...
November 29, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898448/laser-vision-correction-in-treating-myopia
#2
Germano Leal Ehlke, Ronald R Krueger
Myopia is a generally benign refractive error with an increasing prevalence worldwide. It can be corrected temporarily with glasses and contact lenses and permanently with laser vision correction. The 2 main procedures currently being performed for myopia correction are photorefractive keratectomy and laser-assisted in situ keratomileusis. Each technique has its advantages, but they appear to yield similar visual outcomes 1 year after surgery. Laser vision correction for myopia was considered a paradigm shift because healthy eyes could now undergo a surgical procedure to permanently and safely correct the error by altering the center of the cornea, which was previously off limits because of the potential for loss of transparency...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898297/a-novel-pfib-sample-preparation-protocol-for-correlative-3d-x-ray-cnt-and-fib-tof-sims-tomography
#3
Agnieszka Priebe, Guillaume Audoit, Jean-Paul Barnes
We present a novel sample preparation method that allows correlative 3D X-ray Computed Nano-Tomography (CNT) and Focused Ion Beam Time-Of-Flight Secondary Ion Mass Spectrometry (FIB-TOF-SIMS) tomography to be performed on the same sample. In addition, our invention ensures that samples stay unmodified structurally and chemically between the subsequent experiments. The main principle is based on modifying the topography of the X-ray CNT experimental setup before FIB-TOF-SIMS measurements by incorporating a square washer around the sample...
November 19, 2016: Ultramicroscopy
https://www.readbyqxmd.com/read/27888100/harnessing-wharton-s-jelly-stem-cell-differentiation-into-bone-like-nodule-on-calcium-phosphate-substrate-without-osteoinductive-factors
#4
S Mechiche Alami, H Rammal, C Boulagnon-Rombi, F Velard, F Lazar, R Drevet, D Laurent Maquin, S C Gangloff, J Hemmerlé, J C Voegel, G Francius, P Schaaf, F Boulmedais, H Kerdjoudj
An important aim of bone regenerative medicine is to design biomaterials with controlled chemical and topographical features to guide stem cell fate towards osteoblasts without addition of specific osteogenic factors. Herein, we find that sprayed bioactive and biocompatible calcium phosphate substrates (CaP) with controlled topography induce, in a well-orchestrated manner, Wharton's jelly stem cells (WJ-SCs) differentiation into osteoblastic lineage without any osteogenic supplements. The resulting WJ-SCs commitment exhibits features of native bone, through the formation of three-dimensional bone-like nodule with osteocyte-like cells embedded into a mineralized type I collagen...
November 22, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27843292/topography-modified-refraction-tmr-adjustment-of-treated-cylinder-amount-and-axis-to-the-topography-versus-standard-clinical-refraction-in-myopic-topography-guided-lasik
#5
Anastasios John Kanellopoulos
PURPOSE: To evaluate the safety, efficacy, and contralateral eye comparison of topography-guided myopic LASIK with two different refraction treatment strategies. SETTING: Private clinical ophthalmology practice. PATIENTS AND METHODS: A total of 100 eyes (50 patients) in consecutive cases of myopic topography-guided LASIK procedures with the same refractive platform (FS200 femtosecond and EX500 excimer lasers) were randomized for treatment as follows: one eye with the standard clinical refraction (group A) and the contralateral eye with the topographic astigmatic power and axis (topography-modified treatment refraction; group B)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27837120/recommendations-for-high-risk-clinical-target-volume-definition-with-computed-tomography-for-three-dimensional-image-guided-brachytherapy-in-cervical-cancer-patients
#6
Tatsuya Ohno, Masaru Wakatsuki, Takafumi Toita, Yuko Kaneyasu, Ken Yoshida, Shingo Kato, Noriko Li, Sunao Tokumaru, Hitoshi Ikushima, Takashi Uno, Shin-Ei Noda, Tomoko Kazumoto, Yoko Harima
Our purpose was to develop recommendations for contouring the computed tomography (CT)-based high-risk clinical target volume (CTVHR) for 3D image-guided brachytherapy (3D-IGBT) for cervical cancer. A 15-member Japanese Radiation Oncology Study Group (JROSG) committee with expertise in gynecological radiation oncology initiated guideline development for CT-based CTVHR (based on a comprehensive literature review as well as clinical experience) in July 2014. Extensive discussions occurred during four face-to-face meetings and frequent email communication until a consensus was reached...
November 10, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27824375/visual-outcomes-after-lasik-using-topography-guided-vs-wavefront-guided-customized-ablation-systems
#7
Ikuko Toda, Takeshi Ide, Teruki Fukumoto, Kazuo Tsubota
PURPOSE: To evaluate the visual performance of two customized ablation systems (wavefront-guided ablation and topography-guided ablation) in LASIK. METHODS: In this prospective, randomized clinical study, 68 eyes of 35 patients undergoing LASIK were enrolled. Patients were randomly assigned to wavefront-guided ablation using the iDesign aberrometer and STAR S4 IR Excimer Laser system (Abbott Medical Optics, Inc., Santa Ana, CA) (wavefront-guided group; 32 eyes of 16 patients; age: 29...
November 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27824280/the-combined-effect-of-substrate-stiffness-and-surface-topography-on-chondrogenic-differentiation-of-mesenchymal-stem-cells
#8
Yingnan Wu, Zheng Yang, Jaslyn Bee Khuan Law, Ai Yu He, Azlina A Abbas, Vinitha Denslin, Tunku Kamarul, James H Hui, Eng Hin Lee
Stem cell differentiation is guided by contact with the physical microenvironment, influence by both the topography and mechanical properties of the matrix. In this study, the combined effect of substratum nano-topography and mechanical stiffness in directing mesenchymal stem cell (MSC) chondrogenesis was investigated. Three polyesters of varying stiffness were thermally imprinted to create nano-grating or pillar patterns of the same dimension. The surface of the nano-patterned substrate was coated with chondroitin sulfate (CS) to provide an even surface chemistry, with cell-adhesive and chondro-inductive properties, across all polymeric substrates...
November 8, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27819793/in-depth-tem-characterization-of-block-copolymer-pattern-transfer-at-germanium-surfaces
#9
Cian Cummins, Timothy W Collins, Roisin A Kelly, Eoin K McCarthy, Michael A Morris
Dry plasma etching for the pattern transfer of mask features is fundamental to semiconductor processing and the development of device and electrically conducting elements becomes more challenging as features reach the deep nanoscale regime. In this work, high resolution transmission electron microscopy (TEM) coupled with energy dispersive x-ray (EDX) characterization were used to analyze the pattern transfer of graphoepitaxially aligned block copolymer (BCP) features to germanium (Ge) substrates as a function of time...
December 2, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27805532/visual-rehabilitation-after-penetrating-keratoplasty
#10
Leyla Asena, Dilek D Altınörs
OBJECTIVES: Here, our aim was to report our treatment strategies and their results performed for visual rehabilitation after penetrating keratoplasty. MATERIALS AND METHODS: The medical records of 98 patients (54 male/44 female), with results from 104 eyes, who underwent penetrating keratoplasty between January 2013 and January 2015 at the Baskent University Faculty of Medicine, Department of Ophthalmology were reviewed. Patient age, indication for penetrating keratoplasty, interventions performed for visual rehabilitation, follow-up duration, topographic and refractive astigmatism at the end of follow-up, and final best corrected visual acuity results were recorded...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27789947/effects-of-nanoporous-anodic-titanium-oxide-on-human-adipose-derived-stem-cells
#11
Katarzyna Malec, Joanna Góralska, Magdalena Hubalewska-Mazgaj, Paulina Głowacz, Magdalena Jarosz, Pawel Brzewski, Grzegorz D Sulka, Marian Jaskuła, Iwona Wybrańska
The aim of current bone biomaterials research is to design implants that induce controlled, guided, successful, and rapid healing. Titanium implants are widely used in dental, orthopedic, and reconstructive surgery. A series of studies has indicated that cells can respond not only to the chemical properties of the biomaterial, but also, in particular, to the changes in surface topography. Nanoporous materials remain in focus of scientific queries due to their exclusive properties and broad applications. One such material is nanostructured titanium oxide with highly ordered, mutually perpendicular nanopores...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27757010/refractive-lenticule-extraction-relex-through-a-small-incision-smile-for-correction-of-myopia-and-myopic-astigmatism-current-perspectives
#12
Alper Ağca, Ahmet Demirok, Yusuf Yıldırım, Ali Demircan, Dilek Yaşa, Ceren Yeşilkaya, İrfan Perente, Muhittin Taşkapılı
Small-incision lenticule extraction (SMILE) is an alternative to laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) for the correction of myopia and myopic astigmatism. SMILE can be performed for the treatment of myopia ≤-12 D and astigmatism ≤5 D. The technology is currently only available in the VisuMax femtosecond laser platform. It offers several advantages over LASIK and PRK; however, hyperopia treatment, topography-guided treatment, and cyclotorsion control are not available in the current platform...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27736057/scanning-electrochemical-microscopy-a-comprehensive-review-of-experimental-parameters-from-1989-to-2015
#13
David Polcari, Philippe Dauphin-Ducharme, Janine Mauzeroll
Scanning electrochemical microscopy (SECM) is an electroanalytical scanning probe technique capable of imaging substrate topography and local reactivity with high resolution. Since its inception in 1989, it has expanded into a wide variety of research areas including biology, corrosion, energy, kinetics, instrumental development, and surface modification. In the past 25 years, over 1800 peer-reviewed publications have focused on SECM, including several topical reviews. However, these reviews often omit key details, forcing readers to search the literature...
October 13, 2016: Chemical Reviews
https://www.readbyqxmd.com/read/27728957/reconciling-visual-field-defects-and-retinal-nerve-fibre-layer-asymmetric-patterns-in-retrograde-degeneration-an-extended-case-series
#14
Barbara Zangerl, Andrew Whatham, Juno Kim, Agnes Choi, Nagi N Assaad, Michael P Hennessy, Michael Kalloniatis
BACKGROUND: Accurate diagnosis in patients presenting with lesions at various locations within the visual pathway is challenging. This study investigated functional and structural changes secondary to such lesions to identify patterns useful to guide early and effective management. METHODS: Over 10,000 records from patients referred for optic nerve head assessment were reviewed and 31 patients with a final diagnosis of likely neuropathic lesions posterior to the eye were included in the current study...
October 11, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27716184/amino-acid-pet-versus-mri-guided-re-irradiation-in-patients-with-recurrent-glioblastoma-multiforme-gliaa-protocol-of-a-randomized-phase-ii-trial-noa-10-aro-2013-1
#15
Oliver Oehlke, Michael Mix, Erika Graf, Tanja Schimek-Jasch, Ursula Nestle, Irina Götz, Sabine Schneider-Fuchs, Astrid Weyerbrock, Irina Mader, Brigitta G Baumert, Susan C Short, Philipp T Meyer, Wolfgang A Weber, Anca-Ligia Grosu
BACKGROUND: The higher specificity of amino-acid positron emission tomography (AA-PET) in the diagnosis of gliomas, as well as in the differentiation between recurrence and treatment-related alterations, in comparison to contrast enhancement in T1-weighted MRI was demonstrated in many studies and is the rationale for their implementation into radiation oncology treatment planning. Several clinical trials have demonstrated the significant differences between AA-PET and standard MRI concerning the definition of the gross tumor volume (GTV)...
October 5, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27697248/outcomes-of-topography-guided-versus-wavefront-optimized-laser-in-situ-keratomileusis-for-myopia-in-virgin-eyes
#16
Arun Kumar Jain, Chintan Malhotra, Anand Pasari, Pawan Kumar, Majid Moshirfar
PURPOSE: To compare the outcomes of topography-guided and wavefront-optimized treatment in patients having laser in situ keratomileusis (LASIK) for myopia. SETTING: Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India. DESIGN: Prospective contralateral-eye case study. METHODS: Patients had topography-guided LASIK in 1 eye and wavefront-optimized LASIK in the contralateral eye using the Customized Refractive Surgery Master software and Mel 80 excimer laser...
September 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27696229/radon-levels-in-romanian-caves-an-occupational-exposure-survey
#17
Alexandra Cucoş Dinu, Monica I Călugăr, Bety D Burghele, Oana A Dumitru, Constantin Cosma, Bogdan P Onac
A comprehensive radon survey has been carried out in seven caves located in the western half of Romania's most significant karst regions. Touristic and non-touristic caves were investigated with the aim to provide a reliable distribution of their radon levels and evaluate the occupational exposure and associated effective doses. Radon gas concentrations were measured with long-term diffusion-type detectors during two consecutive seasons (warm and cold). All investigated caves exceed the European Union reference level of radon gas at workplaces (300 Bq/m(3))...
October 1, 2016: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/27687762/temporal-stability-analysis-of-surface-soil-water-content-on-two-karst-hillslopes-in-southwest-china
#18
Sheng Wang, Hong Song Chen, Zhiyong Fu, Kelin Wang
Knowledge of the temporal variability of soil water content (SWC) at the hillslope scale is essential for guiding rehabilitation strategies and for optimizing water resource management in the karst region of southwest China. This study aimed to use temporal stability analysis to upscale point-scale measurements to represent mean areal SWC on two typical karst hillslopes. Based on a grid sampling scheme (10 m × 10 m) applied to two 90 m × 120 m plots located on two hillslops, the SWC at a depth of 0-16 cm was measured 11-12 times across 259 sampling points, using time domain reflectometry (TDR) from April 2011 to October 2012...
September 29, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27676584/a-beginner-s-guide-to-atomic-force-microscopy-probing-for-cell-mechanics
#19
Núria Gavara
Atomic Force microscopy (AFM) is becoming a prevalent tool in cell biology and biomedical studies, especially those focusing on the mechanical properties of cells and tissues. The newest generation of bio-AFMs combine ease of use and seamless integration with live-cell epifluorescence or more advanced optical microscopies. As a unique feature with respect to other bionanotools, AFM provides nanometer-resolution maps for cell topography, stiffness, viscoelasticity, and adhesion, often overlaid with matching optical images of the probed cells...
September 27, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27663699/integrating-entropy-based-na%C3%A3-ve-bayes-and-gis-for-spatial-evaluation-of-flood-hazard
#20
Rui Liu, Yun Chen, Jianping Wu, Lei Gao, Damian Barrett, Tingbao Xu, Xiaojuan Li, Linyi Li, Chang Huang, Jia Yu
Regional flood risk caused by intensive rainfall under extreme climate conditions has increasingly attracted global attention. Mapping and evaluation of flood hazard are vital parts in flood risk assessment. This study develops an integrated framework for estimating spatial likelihood of flood hazard by coupling weighted naïve Bayes (WNB), geographic information system, and remote sensing. The north part of Fitzroy River Basin in Queensland, Australia, was selected as a case study site. The environmental indices, including extreme rainfall, evapotranspiration, net-water index, soil water retention, elevation, slope, drainage proximity, and density, were generated from spatial data representing climate, soil, vegetation, hydrology, and topography...
September 24, 2016: Risk Analysis: An Official Publication of the Society for Risk Analysis
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