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https://www.readbyqxmd.com/read/29340362/synergetic-topography-and-chemistry-cues-guiding-osteogenic-differentiation-in-bone-marrow-stromal-cells-through-erk1-2-and-p38-mapk-signaling-pathway
#1
Xinran Zhang, Haotian Li, Chucheng Lin, Congqin Ning, Kaili Lin
Both the topographic surface and chemical composition modification can enhance rapid osteogenic differentiation and bone formation. Till now, the synergetic effects of topography and chemistry cues guiding biological responses have been rarely reported. Herein, the ordered micro-patterned topography and classically essential trace element of strontium (Sr) ion doping were selected to imitate topography and chemistry cues, respectively. The ordered micro-patterned topography on Sr ion-doped bioceramics was successfully duplicated using the nylon sieve as the template...
January 17, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29331438/characterization-of-surface-properties-of-glass-vials-used-as-primary-packaging-material-for-parenterals
#2
Dominique Ditter, Hanns-Christian Mahler, Holger Roehl, Michael Wahl, Joerg Huwyler, Alejandra Nieto, Andrea Allmendinger
The appropriate selection of adequate primary packaging, such as the glass vial, rubber stopper, and crimp cap for parenteral products is of high importance to ensure product stability, microbiological quality (integrity) during storage as well as patient safety. A number of issues can arise when inadequate vial material is chosen, and sole compliance to hydrolytic class I is sometimes not sufficient when choosing a glass vial. Using an appropriate pre-treatment, such as surface modification or coating of the inner vial surface after the vial forming process the glass container quality is often improved and interactions of the formulation with the surface of glass may be minimized...
January 10, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29301768/topography-guided-identification-of-leakage-point-in-central-serous-chorioretinopathy-a-base-for-fluorescein-angiography-free-focal-laser-photocoagulation
#3
Dmitrii S Maltsev, Alexei N Kulikov, Jay Chhablani
PURPOSE: To identify optical coherence tomography (OCT) findings associated with the leakage points in patients with central serous chorioretinopathy (CSC) to provide fluorescein angiography (FA)-free focal laser photocoagulation (FLP) of the leakage point. METHODS: A retrospective study included 48 patients with CSC (48 eyes). Colocalisation of leakage points with pigment epithelial detachments (PEDs) and with areas of photoreceptor outer segments (PROS) layer thinning was evaluated with OCT...
January 4, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29291162/upregulation-of-osteogenesis-of-mesenchymal-stem-cells-with-virus-based-thin-films
#4
REVIEW
Huong Giang Nguyen, Kamolrat Metavarayuth, Qian Wang
A major aim of tissue engineering is to develop biomimetic scaffolding materials that can guide the proliferation, self-renewal and differentiation of multipotent stem cells into specific lineages. Cellular functions can be controlled by the interactions between cells and biomaterials. Therefore, the surface chemistry and topography of support materials play a pivotal role in modulating cell behaviors at many stages of cell growth and development. Due to their highly ordered structure and programmable surface chemistries, which provide unique topography as biomaterials, viral nanoparticles have been utilized as building blocks for targeted cell growth and differentiation...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/29283000/topographic-cues-guide-the-attachment-of-diatom-cells-and-algal-zoospores
#5
Linlin Xiao, John A Finlay, Michael Röhrig, Sophie Mieszkin, Matthias Worgull, Hendrik Hölscher, James A Callow, Maureen E Callow, Michael Grunze, Axel Rosenhahn
Surface topography plays a key role in the colonization of substrata by the colonizing stages of marine fouling organisms. For the innovation of marine antifouling coatings, it is essential to understand how topographic cues affect the settlement of these organisms. In this study, tapered, spiked microstructures and discrete honeycombs of varying feature dimensions were designed and fabricated in order to examine the influence of topography on the attachment of zoospores of the green macroalga Ulva linza and cells of the diatom (microalga) Navicula incerta...
December 28, 2017: Biofouling
https://www.readbyqxmd.com/read/29279863/combinatorial-inputs-to-the-ventral-striatum-from-the-temporal-cortex-frontal-cortex-and-amygdala-implications-for-segmenting-the-striatum
#6
Eun Young Choi, Song-Lin Ding, Suzanne N Haber
The canonical striatal map, based predominantly on frontal corticostriatal projections, divides the striatum into ventromedial-limbic, central-association, and dorsolateral-motor territories. While this has been a useful heuristic, recent studies indicate that the striatum has a more complex topography when considering converging frontal and nonfrontal inputs from distributed cortical networks. The ventral striatum (VS) in particular is often ascribed a "limbic" role, but it receives diverse information, including motivation and emotion from deep brain structures, cognition from frontal cortex, and polysensory and mnemonic signals from temporal cortex...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29215394/visual-outcomes-and-aberrometric-changes-with-topography-guided-photorefractive-keratectomy-treatment-of-irregular-astigmatism-after-penetrating-keratoplasty
#7
Francisco Bandeira E Silva, Rossen Mihaylov Hazarbassanov, Eduardo Martines, José Luis Güell, Ana L Hofling-Lima
PURPOSE: To evaluate the visual acuity and keratometric and aberrometric changes in patients with corneal transplants (PKP), who underwent topography-guided photorefractive keratectomy (TG-PRK) with mitomycin C (MMC). METHODS: In this case study, 15 patients with spherical equivalents ranging from -11.00 to -0.25 diopters (D) who underwent penetrating corneal transplantation and had irregular astigmatism ranging from -7.5 to -2.0 D underwent TG-PRK with MMC. Corneal topography and wavefront of all patients were measured preoperatively and 12 months postoperatively...
December 5, 2017: Cornea
https://www.readbyqxmd.com/read/29212065/development-of-the-visual-system-in-a-burrow-nesting-seabird-leach-s-storm-petrel
#8
Mindaugas Mitkus, Gabrielle A Nevitt, Almut Kelber
Little is known about the development of vision in wild birds. It is unknown, for example, whether the ability to see can be predicted by the level of prenatal growth or whether the eyes are open at hatching in a particular species. In this study, we investigated the growth of eyes, the formation of retinal ganglion cell topography, and the appearance of simple, visually guided behaviours in chicks of a small procellariiform seabird, Leach's storm petrel (Oceanodroma leucorhoa). This semi-precocial species, which has a well-developed sense of smell, nests in underground burrows where adults provision chicks for 6-8 weeks in the dark before fledging...
December 7, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/29205431/anatomic-delineation-of-tarsal-tunnel-innervation-via-ultrasonography
#9
Alvaro Iborra, Manuel Villanueva, Stephen L Barrett, Edgardo Rodriguez-Collazo, Pablo Sanz
OBJECTIVES: High-resolution ultrasonography (US) can play an important role in studying nerves, as it has several advantages. Entrapments of distal tibial nerve branches can be mapped out or diagnosed with selective anesthetic blocks, and US can guide therapeutic procedures, such as radiofrequency ablation and selective infiltrations of specific nerve branches. The aim of this study was to verify that US is an effective method for accurately locating the posterior tibial nerve and its terminal branches, such as the medial calcaneal branch, the first calcaneal branch, and the medial and lateral plantar nerves...
December 4, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29163020/what-drives-bird-vision-bill-control-and-predator-detection-overshadow-flight
#10
REVIEW
Graham R Martin
Although flight is regarded as a key behavior of birds this review argues that the perceptual demands for its control are met within constraints set by the perceptual demands of two other key tasks: the control of bill (or feet) position, and the detection of food items/predators. Control of bill position, or of the feet when used in foraging, and timing of their arrival at a target, are based upon information derived from the optic flow-field in the binocular region that encompasses the bill. Flow-fields use information extracted from close to the bird using vision of relatively low spatial resolution...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29152570/the-mediterranean-overflow-in-the-gulf-of-cadiz-a-rugged-journey
#11
Ricardo F Sánchez-Leal, María Jesús Bellanco, Luis Miguel Fernández-Salas, Jesús García-Lafuente, Marc Gasser-Rubinat, César González-Pola, Francisco J Hernández-Molina, Josep L Pelegrí, Alvaro Peliz, Paulo Relvas, David Roque, Manuel Ruiz-Villarreal, Simone Sammartino, José Carlos Sánchez-Garrido
The pathways and transformations of dense water overflows, which depend on small-scale interactions between flow dynamics and erosional-depositional processes, are a central piece in the ocean's large-scale circulation. A novel, high-resolution current and hydrographic data set highlights the intricate pathway travelled by the saline Mediterranean Overflow as it enters the Atlantic. Interaction with the topography constraints its spreading. Over the initial 200 km west of the Gibraltar gateway, distinct channels separate the initial gravity current into several plunging branches depth-sorted by density...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29117953/brain-microbleeds-anticoagulation-and-hemorrhage-risk-meta-analysis-in-stroke-patients-with-af
#12
REVIEW
Andreas Charidimou, Christopher Karayiannis, Tae-Jin Song, Dilek Necioglu Orken, Vincent Thijs, Robin Lemmens, Jinkwon Kim, Su Mei Goh, Thanh G Phan, Cathy Soufan, Ronil V Chandra, Lee-Anne Slater, Shamir Haji, Vincent Mok, Solveig Horstmann, Kam Tat Leung, Yuichiro Kawamura, Nobuyuki Sato, Naoyuki Hasebe, Tsukasa Saito, Lawrence K S Wong, Yannie Soo, Roland Veltkamp, Kelly D Flemming, Toshio Imaizumi, Velandai Srikanth, Ji Hoe Heo
OBJECTIVES: To assess the association between cerebral microbleeds (CMBs) and future spontaneous intracerebral hemorrhage (ICH) risk in ischemic stroke patients with nonvalvular atrial fibrillation (AF) taking oral anticoagulants. METHODS: This was a meta-analysis of cohort studies with >50 patients with recent ischemic stroke and documented AF, brain MRI at baseline, long-term oral anticoagulation treatment, and ≥6 months of follow-up. Authors provided summary-level data on stroke outcomes stratified by CMB status...
December 5, 2017: Neurology
https://www.readbyqxmd.com/read/29104650/predictive-factors-of-pancreatic-necrosectomy-following-percutaneous-catheter-drainage-as-a-primary-treatment-of-patients-with-infected-necrotizing-pancreatitis
#13
Xi Cao, Feng Cao, Ang Li, Xiang Gao, Xiao-Hui Wang, Dian-Gang Liu, Yu Fang, Dong-Hai Guo, Fei Li
Pancreatic necrosectomy (PN) following percutaneous catheter drainage (PCD) is an effective method of treating patients with necrotizing pancreatitis, however, the predictive factors for PN after PCD have not yet been identified. A total of 74 patients with suspected infected necrotizing pancreatitis (INP) and peripancreatic fluid collection were enrolled in the current study between October 2010 and October 2015. These patients received ultrasound or computer topography guided PCD followed by PN. Patients were divided into two groups: i) A PCD-alone group (n=32) and ii) a PCD+necrosectomy group (n=42)...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29075798/microelectrode-array-induced-neuronal-alignment-directs-neurite-outgrowth-analysis-using-a-fast-fourier-transform-fft
#14
Viktorija Radotić, Dries Braeken, Damir Kovačić
Many studies have shown that the topography of the substrate on which neurons are cultured can promote neuronal adhesion and guide neurite outgrowth in the same direction as the underlying topography. To investigate this effect, isotropic substrate-complementary metal-oxide-semiconductor (CMOS) chips were used as one example of microelectrode arrays (MEAs) for directing neurite growth of spiral ganglion neurons. Neurons were isolated from 5 to 7-day-old rat pups, cultured 1 day in vitro (DIV) and 4 DIV, and then fixed with 4% paraformaldehyde...
December 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29016430/an-anatomic-and-radiographic-study-of-the-distal-tibial-epiphysis
#15
Cynthia V Nguyen, Janelle D Greene, Daniel R Cooperman, Raymond W Liu
BACKGROUND: Although the undulating shape of the distal tibial epiphysis is well recognized, its anatomic features have not been well quantified in the literature. To guide the placement of surgical implants about the distal tibial physis, we investigated the topographical anatomy of the distal tibial epiphysis and explored the ability of standard radiographs to visualize the physis. METHODS: We studied 30 cadaveric distal tibial epiphyses in specimens 3 to 14 years of age...
October 9, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28994886/is-there-a-real-benefit-of-hyperbaric-oxygenotherapy-in-the-treatment-of-necrotizing-otitis-externa
#16
Ali Mardassi, Senda Turki, Rim Lahiani, Hajer Mbarek, Sonia Benzarti, Hédi Gharsallah
INTRODUCTION: Necrotizing otitis externa remains a severe and sometimes life-threatening disease in diabetic patient. Many therapeutic approaches have been described but what about the real benefit of hyperbaric oxygenotherapy in the management of this disease? METHODS: The authors reported a retrospective study about 42 patients treated for necrotizing external otitis over a period of 9 years (2006 to 2014). The patients were treated either by only antibiotherapy (23 cases) or with both antibiotherapy and hyperbaric oxygenotherapy (19 cases)...
December 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28991336/four-stage-procedure-for-keratoconus-icrs-implantation-corneal-cross-linking-toric-phakic-intraocular-lens-implantation-and-topography-guided-photorefractive-keratectomy
#17
Efekan Coskunseven, Daya Papalkar Sharma, Michael A Grentzelos, Onurcan Sahin, George D Kymionis, Ioannis Pallikaris
PURPOSE: To evaluate a four-stage combined treatment for keratoconus including intrastromal corneal ring segment (ICRS) implantation followed by corneal cross-linking (CXL), toric phakic intraocular lens (IOL) implantation, and topography-guided photorefractive keratectomy (TG-PRK). METHODS: In this retrospective interventional case series, 11 eyes of 7 patients with progressive keratoconus were treated with a four-stage procedure including the following: Keraring ICRS (Mediphacos Ltda, Belo Horizonte, Brazil) implantation followed by CXL, phakic IOL implantation, and TG-PRK (minimum 6 months between each stage)...
October 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28979199/empathy-pain-and-attention-cues-that-predict-pain-stimulation-to-the-partner-and-the-self-capture-visual-attention
#18
Lingdan Wu, Ursula Kirmse, Tobias Flaisch, Ganna Boiandina, Anna Kenter, Harald T Schupp
Empathy motivates helping and cooperative behaviors and plays an important role in social interactions and personal communication. The present research examined the hypothesis that a state of empathy guides attention towards stimuli significant to others in a similar way as to stimuli relevant to the self. Sixteen couples in romantic partnerships were examined in a pain-related empathy paradigm including an anticipation phase and a stimulation phase. Abstract visual symbols (i.e., arrows and flashes) signaled the delivery of a Pain or Nopain stimulus to the partner or the self while dense sensor event-related potentials (ERPs) were simultaneously recorded from both persons...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28945581/terrain-model-reconstruction-from-terrestrial-lidar-data-using-radial-basis-functions
#19
Jules Morel, Alexandra Bac, Cedric Vega
The presence of vegetation and the terrain topography itself generate strong occlusions causing large gaps in terrestrial laser scanning (TLS) data at the ground level as well as a risk of integrating above-ground objects. This article introduces a surface-approximation algorithm dedicated to extracting digital terrain models (DTMs) from terrestrial TLS data acquired in forest areas. The proposed method is based on the combination of a quadtree subdivision of space guided by the local density and distribution of data together with a surface modeling via radial basis functions, which are used as partitions of unity for merging local quadratic approximating patches...
2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28940157/climbing-fiber-development-is-impaired-in-postnatal-car8-wdl-mice
#20
Lauren N Miterko, Roy V Sillitoe
The cerebellum is critical for an array of motor functions. During postnatal development, the Purkinje cells (PCs) guide afferent topography to establish the final circuit. Perturbing PC morphogenesis or activity during development can result in climbing fiber (CF) multi-innervation or mis-patterning. Structural defects during circuit formation typically have long-term effects on behavior as they contribute to the phenotype of movement disorders such as cerebellar ataxia. The Car8 (wdl) mouse is one model in which early circuit destruction influences movement...
September 22, 2017: Cerebellum
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