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https://www.readbyqxmd.com/read/28914632/stepwise-guided-photorefractive-keratectomy-in-treatment-of-irregular-astigmatism-after-penetrating-keratoplasty-and-deep-anterior-lamellar-keratoplasty
#1
Nir Sorkin, Adi Einan-Lifshitz, Sagi Abelson, Tanguy Boutin, Mahmood Showail, Armand Borovik, Zach Ashkenazy, Clara C Chan, David S Rootman
PURPOSE: To report the outcome of stepwise ablation using topography-guided photorefractive keratectomy to treat irregular astigmatism after either penetrating keratoplasty (PKP) or deep anterior lamellar keratoplasty (DALK). METHODS: This is a retrospective, interventional analysis including patients with irregular astigmatism after either PKP or DALK, who underwent topography-guided photorefractive keratectomy. The entire cohort was analyzed, as well as the PKP and DALK groups separately...
September 12, 2017: Cornea
https://www.readbyqxmd.com/read/28902914/oxidative-stress-induces-dysregulated-autophagy-in-corneal-epithelium-of-keratoconus-patients
#2
Rohit Shetty, Anupam Sharma, Natasha Pahuja, Priyanka Chevour, Neeraja Padmajan, Kamesh Dhamodaran, Chaitra Jayadev, Rudy M M A Nuijts, Arkasubhra Ghosh, Jeyabalan Nallathambi
Oxidative stress is one of the key factors that contributes to the pathogenesis of keratoconus (KC). Macroautophagy is a vital cellular mechanism that is activated in response to oxidative stress. The aim of this study was to understand the role of the autophagic lysosomal pathway in the oxidative damage of KC corneal epithelium and the human corneal epithelial cell line (HCE).The corneal epithelium was collected from 78 KC patients undergoing corneal cross-linking or topography guided photorefractive keratectomy...
2017: PloS One
https://www.readbyqxmd.com/read/28885543/3d-printed-microgroove-pattern-driven-generation-of-oriented-ligamentous-architectures
#3
Chan Ho Park, Kyoung-Hwa Kim, Yong-Moo Lee, William V Giannobile, Yang-Jo Seol
Specific orientations of regenerated ligaments are crucially required for mechanoresponsive properties and various biomechanical adaptations, which are the key interplay to support mineralized tissues. Although various 2D platforms or 3D printing systems can guide cellular activities or aligned organizations, it remains a challenge to develop ligament-guided, 3D architectures with the angular controllability for parallel, oblique or perpendicular orientations of cells required for biomechanical support of organs...
September 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28884680/thigmo-responses-the-fungal-sense-of-touch
#4
Mariana Cruz Almeida, Alexandra C Brand
The growth and development of most fungi take place on a two-dimensional surface or within a three-dimensional matrix. The fungal sense of touch is therefore critical for fungi in the interpretation of their environment and often signals the switch to a new developmental state. Contact sensing, or thigmo-based responses, include thigmo differentiation, such as the induction of invasion structures by plant pathogens in response to topography; thigmonasty, where contact with a motile prey rapidly triggers its capture; and thigmotropism, where the direction of hyphal growth is guided by physical features in the environment...
April 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28880340/topography-guided-photorefractive-keratectomy-in-the-treatment-of-corneal-scarring
#5
Nir Sorkin, Adi Einan-Lifshitz, Tanguy Boutin, Mahmood Showail, Armand Borovik, Clara C Chan, David S Rootman
PURPOSE: To report the outcome of topography-guided photorefractive keratectomy (TG-PRK) in the treatment of patients with corneal scarring. METHODS: A retrospective, interventional case series including 6 eyes of 6 patients with corneal scarring and irregular astigmatism who underwent TG-PRK. The etiologies for scarring were: infectious corneal ulcers, foreign body trauma, LASIK flap buttonhole, and lamellar keratoplasties performed to correct corneal perforation secondary to corneal melting...
September 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28841184/experimental-investigation-on-surface-quality-processed-by-self-excited-oscillation-pulsed-waterjet-peening
#6
Xiaolong Ding, Yong Kang, Deng Li, Xiaochuan Wang, Dongping Zeng
High-speed waterjet peening technology has attracted a lot of interest and is now being widely studied due to its great ability to strengthen metal surfaces. In order to further improve the mechanical properties of metals, self-excited oscillation pulsed waterjets (SOPWs) were used for surface peening with an experimental investigation focused on the surface topography and properties. By impinging the aluminum alloy (5052) specimens with SOPWs issuing from an organ-pipe oscillation nozzle, the hardness and roughness at various inlet pressures and stand-off distances were measured and analyzed, as well as the residual stress...
August 25, 2017: Materials
https://www.readbyqxmd.com/read/28836025/anatomical-topography-of-the-inferior-lumbar-triangle-for-transversus-abdominis-block
#7
Gkionoul Nteli Chatzioglou, Hassan Bagheri, Yelda Pinar, Figen Govsa
BACKGROUND: Rapid development of anesthetic techniques of thoracic paravertebral block required to redefine anatomical landmarks of the inferior lumbar (Petit) triangle (ILT). Anesthesiologists are mainly interested in the ILT to perform the transversus abdominis plane (TAP) block. The aim of this study was to provide comprehensive information of the ILT to improve the success of TAP block. METHODS: Descriptional anatomy of ILTs such as dimensions, space, area, and types was analyzed in 25 preserved adult male cadavers...
August 23, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28831306/polar-value-analysis-of-low-to-moderate-astigmatism-with-wavefront-guided-sub-bowman-keratomileusis
#8
Pisong Yan, Zhiyu Du, Yu Zhang
PURPOSE: To evaluate the astigmatic outcomes of wavefront-guided sub-Bowman keratomileusis (WFG-SBK) for low to moderate myopic astigmatism. METHODS: This study enrolled 100 right eyes from 100 patients who underwent WFG-SBK for the correction of myopia and astigmatism. The polar value method was performed with anterior and posterior corneal astigmatism measured with Scheimpflug camera combined with Placido corneal topography (Sirius, CSO) and refractive astigmatism preoperatively and 1 month, 3 months, and 6 months postoperatively...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28819093/non-seminomatous-germ-cell-tumor-presenting-with-superior-vena-cava-syndrome
#9
Paolo K Soriano, Muhammad F Iqbal, Omar M Siddiqui, Jeff F Wang, Meghna R Desai
BACKGROUND Primary mediastinal non-seminomatous germ cell tumors (NSGCTs) are aggressive and carry a poor five-year disease free survival rate even with aggressive treatment. We describe a young adult male with primary mediastinal NSGCT presenting with airway obstruction and superior vena cava syndrome (SVCS). CASE REPORT The patient presented with four weeks of nonproductive cough, weight loss, and right-sided pleuritic chest pain. Chest computed topography (CT) imaging demonstrated a right-sided mediastinal mass determined as a yolk sac tumor on biopsy...
August 18, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28815971/topographical-and-electrical-stimulation-of-neuronal-cells-through-microwrinkled-conducting-polymer-biointerfaces
#10
Alberto Bonisoli, Attilio Marino, Gianni Ciofani, Francesco Greco
The development of smart biointerfaces combining multiple functions is crucial for triggering a variety of cellular responses. In this work, wrinkled organic interfaces based on the conducting polymer poly(3,4-ethylene dioxythiophene) doped with poly(styrene sulfonate) are developed with the aim to simultaneously convey electrical and topographical stimuli to cultured cells. The surface wrinkling of thin films on heat-shrink polymer sheets allows for rapid patterning of self-assembled anisotropic topographies characterized by micro/sub-microscale aligned wrinkles...
August 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28774013/additive-manufacturing-of-patient-customizable-scaffolds-for-tubular-tissues-using-the-melt-drawing-method
#11
Yu Jun Tan, Xipeng Tan, Wai Yee Yeong, Shu Beng Tor
Polymeric fibrous scaffolds for guiding cell growth are designed to be potentially used for the tissue engineering (TE) of tubular organs including esophagi, blood vessels, tracheas, etc. Tubular scaffolds were fabricated via melt-drawing of highly elastic poly(l-lactide-co-ε-caprolactone) (PLC) fibers layer-by-layer on a cylindrical mandrel. The diameter and length of the scaffolds are customizable via 3D printing of the mandrel. Thickness of the scaffolds was varied by changing the number of layers of the melt-drawing process...
November 3, 2016: Materials
https://www.readbyqxmd.com/read/28759818/histological-topography-of-the-atrioventricular-node-and-its-extensions-in-relation-to-the-cardiothoracic-surgical-landmarks-in-normal-human-hearts
#12
Arpandeep Randhawa, Tulika Gupta, Anjali Aggarwal, Daisy Sahni, Rana Sandip Singh
BACKGROUND: Atrioventricular (AV) nodal injury which results in cardiac conduction disorders is one of the potential complications of heart valve surgeries and radiofrequency catheter ablations. Understanding the topography of the AV conduction system in relation to the tricuspid and mitral valves will help in reducing these complications. METHODS: A tissue block of 3cmx4cm, which contain the AV node, bundle of His and the AV nodal extensions, was excised at the AV septal junction in 20 apparently normal human hearts...
September 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28757164/surface-topography-guides-morphology-and-spatial-patterning-of-induced-pluripotent-stem-cell-colonies
#13
Giulio Abagnale, Antonio Sechi, Michael Steger, Qihui Zhou, Chao-Chung Kuo, Gülcan Aydin, Carmen Schalla, Gerhard Müller-Newen, Martin Zenke, Ivan G Costa, Patrick van Rijn, Arnold Gillner, Wolfgang Wagner
The relevance of topographic cues for commitment of induced pluripotent stem cells (iPSCs) is largely unknown. In this study, we demonstrate that groove-ridge structures with a periodicity in the submicrometer range induce elongation of iPSC colonies, guide the orientation of apical actin fibers, and direct the polarity of cell division. Elongation of iPSC colonies impacts also on their intrinsic molecular patterning, which seems to be orchestrated from the rim of the colonies. BMP4-induced differentiation is enhanced in elongated colonies, and the submicron grooves impact on the spatial modulation of YAP activity upon induction with this morphogen...
August 8, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28744097/comparison-of-corneal-power-obtained-from-verion-image-guided-surgery-system-and-four-other-devices
#14
Hung-Yuan Lin, Hsin-Yang Chen, Han Bor Fam, Ya-Jung Chuang, Ronald Yeoh, Pi-Jung Lin
PURPOSE: To assess the corneal keratometric values obtained using the VERION image-guided surgery system and other devices. METHODS: This study evaluated the right eyes of 115 cataract patients before intraocular lens (IOL) implantation through consecutive tests using 5 devices: VERION Reference Unit, Placido-based corneal topography (OPD-Scan III), monochromatic light-emitting diodes (LenStar LS900 and AL-Scan), and rotary prism technology (auto kerato-refractometer KR-8800)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28728969/a-nanoporous-titanium-surface-promotes-the-maturation-of-focal-adhesions-and-formation-of-filopodia-with-distinctive-nanoscale-protrusions-by-osteogenic-cells
#15
Dainelys Guadarrama Bello, Aurélien Fouillen, Antonella Badia, Antonio Nanci
While topography is a key determinant of the cellular response to biomaterials, the mechanisms implicated in the cell-surface interactions are complex and still not fully elucidated. In this context, we have examined the effect of nanoscale topography on the formation of filopodia, focal adhesions, and gene expression of proteins associated with cell adhesion and sensing. Commercially pure titanium discs were treated by oxidative nanopatterning with a solution of H2SO4/H2O2 50:50 (v/v). Scanning electron microscopy and atomic force microscopy characterizations showed that this facile chemical treatment efficiently creates a unique nanoporous surface with a root-mean-square roughness of 11...
July 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28724823/topography-guided-neutralization-technique-for-the-management-of-flap-complication-in-laser-in-situ-keratomileusis
#16
Rohit Shetty, Rushad Shroff, Tushar Grover, T Roshan, Chaitra Jayadev
A 29-year-old male was referred following a flap loss after the creation of a thin, irregular flap with a visual acuity of logMAR 0.1 with -2.0 DS-2.75 DC × 175°. Corneal topography and anterior segment optical coherence tomography revealed an irregular corneal curvature and epithelial profile. Phototherapeutic keratectomy (PTK) followed by Topography - Guided Custom Ablation Treatment (TCAT), as a modification of the topographic neutralization technique protocol, was planned to regularize the corneal surface and treat the residual refractive error...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28714577/direct-laser-interference-patterning-of-cocr-alloy-surfaces-to-control-endothelial-cell-and-platelet-response-for-cardiovascular-applications
#17
Romain Schieber, Federico Lasserre, Michael Hans, Marc Fernández-Yagüe, Maribel Díaz-Ricart, Ginés Escolar, Maria-Pau Ginebra, Frank Mücklich, Marta Pegueroles
The main drawbacks of cardiovascular bare-metal stents (BMS) are in-stent restenosis and stent thrombosis as a result of an incomplete endothelialization after stent implantation. Nano- and microscale modification of implant surfaces is a strategy to recover the functionality of the artery by stimulating and guiding molecular and biological processes at the implant/tissue interface. In this study, cobalt-chromium (CoCr) alloy surfaces are modified via direct laser interference patterning (DLIP) in order to create linear patterning onto CoCr surfaces with different periodicities (≈3, 10, 20, and 32 µm) and depths (≈20 and 800 nm)...
July 17, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28706442/topography-modified-refraction-adjustment-of-treated-cylinder-amount-and-axis-to-the-topography-versus-standard-clinical-refraction-in-myopic-topography-guided-lasik
#18
COMMENT
https://www.readbyqxmd.com/read/28667901/fibrous-scaffolds-potentiate-the-paracrine-function-of-mesenchymal-stem-cells-a-new-dimension-in-cell-material-interaction
#19
Ni Su, Peng-Lai Gao, Kai Wang, Jin-Yang Wang, Yi Zhong, Ying Luo
While the studies on the material interaction with mesenchymal stem cells (MSCs) have been mainly focused on the ability of materials to provide environment to regulate cell viability, proliferation or differentiation, the therapeutic effects of MSC-material constructs may result from the secretion of immunomodulatory and angiogenic cytokines from MSCs. Here, electrospun scaffolds composed of fibers in random, aligned and mesh-like patterns were fabricated, and the paracrine behavior of adipose-derived MSCs (Ad-MSCs) on the scaffolds were investigated in comparison to the cell culture via conventional microplates...
June 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/28637399/biomineralized-recombinant-collagen-based-scaffold-mimicking-native-bone-enhances-mesenchymal-stem-cell-interaction-and-differentiation
#20
Gloria Belén Ramirez-Rodríguez, Monica Montesi, Silvia Panseri, Simone Sprio, Anna Tampieri, Monica Sandri
The need of synthetic bone grafts that recreate from macro to nanoscale level the biochemical and biophysical cues of bone extracellular matrix (ECM) has been a major driving force for the development of new generation of biomaterials. In this study, synthetic bone substitutes have been synthesized via biomimetic mineralization of a recombinant collagen type I derived peptide (RCP), enriched in tri-amino acid sequence arginine-glycine-aspartate (RGD). 3D isotropic porous scaffolds of three different compositions are developed by freeze-drying: non-mineralized (RCP, as a control), mineralized (Ap/RCP) and mineralized scaffolds in presence of magnesium (MgAp/RCP) that closely imitate bone composition...
June 22, 2017: Tissue Engineering. Part A
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