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https://www.readbyqxmd.com/read/29754993/topography-guided-lasik-versus-small-incision-lenticule-extraction-long-term-refractive-and-quality-of-vision-outcomes
#1
Anastasios John Kanellopoulos
No abstract text is available yet for this article.
May 10, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29741115/the-role-of-biomaterials-in-implantation-for-central-nervous-system-injury
#2
Yu-Shuan Chen, Horng-Jyh Harn, Tzyy-Wen Chiou
Permanent deficits that occur in memory, sensation, and cognition can result from central nervous system (CNS) trauma that causes dysfunction and/or unregulated CNS regeneration. Some therapeutic approaches are preferentially applied to the human body. Therefore, cell transplantation, one of the therapeutic strategies, may be used to benefit people. However, poor cell viability and low efficacy are the limitations to cell transplantation strategies. Biomaterials have been widely used in several fields (e.g...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29728714/why-the-impact-of-mechanical-stimuli-on-stem-cells-remains-a-challenge
#3
REVIEW
Roman Goetzke, Antonio Sechi, Laura De Laporte, Sabine Neuss, Wolfgang Wagner
Mechanical stimulation affects growth and differentiation of stem cells. This may be used to guide lineage-specific cell fate decisions and therefore opens fascinating opportunities for stem cell biology and regenerative medicine. Several studies demonstrated functional and molecular effects of mechanical stimulation but on first sight these results often appear to be inconsistent. Comparison of such studies is hampered by a multitude of relevant parameters that act in concert. There are notorious differences between species, cell types, and culture conditions...
May 4, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29702292/tissue-engineered-spiral-nerve-guidance-conduit-for-peripheral-nerve-regeneration
#4
Wei Chang, Munish B Shah, Paul Lee, Xiaojun Yu
Recently in peripheral nerve regeneration, preclinical studies have shown that the use of nerve guidance conduits (NGCs) with multiple longitudinally channels and intra-luminal topography enhance the functional outcomes when bridging a nerve gap caused by traumatic injury. These features not only provide guidance cues for regenerating nerve, but also become the essential approaches for developing a novel NGC. In this study, a novel spiral NGC with aligned nanofibers and wrapped with an outer nanofibrous tube was first developed and investigated...
April 24, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29690856/human-amniotic-membrane-with-aligned-electrospun-fiber-as-scaffold-for-aligned-tissue-regeneration
#5
Hanis Nazihah Hasmad, Mohd Reusmaazran Yusof, Zainul Rashid Mohd Razi, Ruszymah Binti Haji Idrus, Shiplu Roy Chowdhury
Fabrication of composite scaffolds is one of the strategies proposed to enhance the functionality of tissue engineered scaffolds for improved tissue regeneration. By combining multiple elements together, unique biomimetic scaffolds with desirable physical and mechanical properties can be tailored for tissue-specific applications. Despite having a highly porous structure, the utility of electrospun fibers (EF) as scaffold is usually hampered by their insufficient mechanical strength. In this study, we attempted to produce a mechanically competent scaffold with cell-guiding ability by fabricating aligned PLGA fibers on decellularized human amniotic membrane (HAM), known to possess favorable tensile and wound healing properties...
April 25, 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29677181/exploiting-glycan-topography-for-computational-design-of-env-glycoprotein-antigenicity
#6
Wen-Han Yu, Peng Zhao, Monia Draghi, Claudia Arevalo, Christina B Karsten, Todd J Suscovich, Bronwyn Gunn, Hendrik Streeck, Abraham L Brass, Michael Tiemeyer, Michael Seaman, John R Mascola, Lance Wells, Douglas A Lauffenburger, Galit Alter
Mounting evidence suggests that glycans, rather than merely serving as a "shield", contribute critically to antigenicity of the HIV envelope (Env) glycoprotein, representing critical antigenic determinants for many broadly neutralizing antibodies (bNAbs). While many studies have focused on defining the role of individual glycans or groups of proximal glycans in bNAb binding, little is known about the effects of changes in the overall glycan landscape in modulating antibody access and Env antigenicity...
April 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29675388/consistent-comparison-of-angle-kappa-adjustment-between-oculyzer-and-topolyzer-vario-topography-guided-lasik-for-myopia-by-ex500-excimer-laser
#7
Ming-Shen Sun, Li Zhang, Ning Guo, Yan-Zheng Song, Feng-Ju Zhang
AIM: To evaluate and compare the uniformity of angle Kappa adjustment between Oculyzer and Topolyzer Vario topography guided ablation of laser in situ keratomileusis (LASIK) by EX500 excimer laser for myopia. METHODS: Totally 145 cases (290 consecutive eyes )with myopia received LASIK with a target of emmetropia. The ablation for 86 cases (172 eyes) was guided manually based on Oculyzer topography (study group), while the ablation for 59 cases (118 eyes) was guided automatically by Topolyzer Vario topography (control group)...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29668260/rational-design-of-semiconductor-nanostructures-for-functional-subcellular-interfaces
#8
Ramya Parameswaran, Bozhi Tian
One of the fundamental questions guiding research in the biological sciences is how cellular systems process complex physical and environmental cues and communicate with each other across multiple length scales. Importantly, aberrant signal processing in these systems can lead to diseases that can have devastating impacts on human lives. Biophysical studies in the past several decades have demonstrated that cells can respond to not only biochemical cues but also mechanical and electrical ones. Thus, the development of new materials that can both sense and modulate all of these pathways is necessary...
April 18, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29620843/biofunctionalized-3d-nanopillar-arrays-fostering-cell-guidance-and-promoting-synapse-stability-and-neuronal-activity-in-networks
#9
Hayder Amin, Michele Dipalo, Francesco De Angelis, Luca Berdondini
A controlled geometry of in vitro neuronal networks allows investigation of the cellular mechanisms that underlie neuron-to-neuron and neuron-extracellular matrix interactions, which are essential to biomedical research. Herein, we report a selective guidance of primary hippocampal neurons by using arrays of three-dimensional vertical nanopillars (NPs) functionalized with a specific adhesion-promoting molecule-poly-dl-ornithine (PDLO). We show that 90% of neuronal cells are guided exclusively on the combinatorial PDLO/NP substrate...
April 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29610714/visual-and-refractive-outcomes-of-topography-guided-laser-assisted-in-situ-keratomileusis-in-virgin-eyes
#10
Sharif Hashmani, Nauman Hashmani, Husna Haroon, Yusra Hashmi
Introduction We wanted to assess the efficacy, predictability, and stability of topography-guided, laser-assisted in situ keratomileusis (TGL) on normal untreated eyes with a preoperative best corrected visual acuity (BCVA) of 20/20. Methods This was a retrospective, non-randomized, and single arm study evaluating the outcomes of TGL in eyes with a preoperative BCVA of 20/20. We included 50 eyes of 50 patients who presented to the Hashmanis Hospital, Pakistan and were followed for six months postoperatively...
January 31, 2018: Curēus
https://www.readbyqxmd.com/read/29610024/topography-guided-transepithelial-photorefractive-keratectomy-to-correct-irregular-refractive-errors-after-radial-keratotomy
#11
Mohammad Ghoreishi, Alireza Peyman, Nima Koosha, Khodayar Golabchi, Mohsen Pourazizi
PURPOSE: To evaluate the efficacy and safety of topography-guided transepithelial photorefractive keratectomy (PRK) in a group of patients with post-radial keratotomy (RK) showing irregular corneas. SETTING: Feiz University Hospital, Isfahan, Iran. DESIGN: Prospective case series. METHODS: Consecutive patients who had irregular astigmatism after RK with stable refraction and topography for at least 1 year were recruited...
March 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29528795/cross-linking-multilayers-of-poly-l-lysine-and-hyaluronic-acid-effect-on-mesenchymal-stem-cell-behavior
#12
Marcus S Niepel, Fadi Almouhanna, Bhavya K Ekambaram, Matthias Menzel, Andreas Heilmann, Thomas Groth
BACKGROUND: Cells possess a specialized machinery through which they can sense physical as well as chemical alterations in their surrounding microenvironment that affect their cellular behavior. AIM: In this study, we aim to establish a polyelectrolyte multilayer system of 24 layers of poly-l-lysine and hyaluronic acid to control stem cell response after chemical cross-linking. METHODS AND RESULTS: The multilayer build-up process is monitored using different methods, which show that the studied polyelectrolyte multilayer system grows exponentially following the islands and islets theory...
February 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29522224/clinical-outcomes-of-smile-with-a-triple-centration-technique-and-corneal-wavefront-guided-transepithelial-prk-in-high-astigmatism
#13
Ikhyun Jun, David Sung Yong Kang, Dan Z Reinstein, Samuel Arba-Mosquera, Timothy J Archer, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To comparatively investigate the clinical outcomes, vector parameters, and corneal aberrations of small incision lenticule extraction (SMILE) with a triple centration technique and corneal wavefront-guided transepithelial photorefractive keratectomy (PRK) for the correction of high astigmatism. METHODS: This retrospective, comparative case series study included 89 eyes (89 patients) that received treatment for myopia with high astigmatism (≥ 2.50 diopters) using SMILE with a triple centration technique (SMILE group; 45 eyes) and corneal wavefront-guided transepithelial PRK (transepithelial PRK group; 44 eyes)...
March 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29488841/dissociable-signatures-of-visual-salience-and-behavioral-relevance-across-attentional-priority-maps-in-human-cortex
#14
Thomas C Sprague, Sirawaj Itthipuripat, Vy A Vo, John T Serences
Computational models posit that visual attention is guided by activity within spatial maps that index the image-computable salience and the behavioral relevance of objects in the scene. These spatial maps are theorized to be instantiated as activation patterns across a series of retinotopic visual regions in occipital, parietal, and frontal cortex. While previous research has identified sensitivity to either the behavioral relevance or the image-computable salience of different scene elements, the simultaneous influence of these factors on neural 'attentional priority maps' in human cortex is not well understood...
February 28, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29457860/controlling-the-outgrowth-and-functions-of-neural-stem-cells-the-effect-of-surface-topography
#15
REVIEW
Chara Simitzi, Kanelina Karali, Anthi Ranella, Emmanuel Stratakis
Neural stem cells (NSCs) are self-renewing cells that generate the major cell types of the central nervous system, namely neurons, astrocytes and oligodendrocytes, during embryonic development and in the adult brain. NSCs reside in a complex niche where they are exposed to a plethora of signals, including both soluble and physical signals such as compressive and shear stresses, but also discontinuities and differences in morphology of the extracellular environment, termed as topographical features. Different approaches that incorporate artificial micro- and nano-scale surface topographical features have been developed aiming to recapitulate the in vivo NSC niche discontinuities and features, particularly for in vitro studies...
February 19, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29454641/beyond-the-frn-broadening-the-time-course-of-eeg-and-erp-components-implicated-in-reward-processing
#16
REVIEW
James E Glazer, Nicholas J Kelley, Narun Pornpattananangkul, Vijay A Mittal, Robin Nusslock
Most reward-related electroencephalogram (EEG) studies focus exclusively on the feedback-related negativity (FRN, also known as feedback negativity or FN, medial-frontal negativity or MFN, feedback error-related negativity or fERN, and reward positivity or RewP). This component is usually measured approximately 200-300 ms post-feedback at a single electrode in the frontal-central area (e.g., Fz or FCz). The present review argues that this singular focus on the FRN fails to leverage EEG's greatest strength, its temporal resolution, by underutilizing the rich variety of event-related potential (ERP) and EEG time-frequency components encompassing the wider temporal heterogeneity of reward processing...
February 15, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29425391/incidence-and-outcomes-of-optical-zone-enlargement-and-recentration-after-previous-myopic-lasik-by-topography-guided-custom-ablation
#17
Dan Z Reinstein, Timothy J Archer, Glenn I Carp, Alastair J Stuart, Elizabeth L Rowe, Andrew Nesbit, Tara Moore
PURPOSE: To report the incidence, visual and refractive outcomes, optical zone enlargement, and recentration using topography-guided CRS-Master TOSCA II software with the MEL 80 excimer laser (Carl Zeiss Meditec AG, Jena, Germany) after primary myopic laser refractive surgery. METHODS: Retrospective analysis of 73 eyes (40 patients) with complaints of night vision disturbances due to either a decentration or small optical zone following a primary myopic laser refractive surgery procedure using the MEL 80 laser...
February 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29425177/nano-pore-size-of-alumina-affects-osteoblastic-response
#18
Federico Mussano, Tullio Genova, Francesca Giulia Serra, Massimo Carossa, Luca Munaron, Stefano Carossa
The rapid development and application of nanotechnology to biological interfaces has impacted the bone implant field, allowing researchers to finely modulate the interface between biomaterials and recipient tissues. In the present study, oxidative anodization was exploited to generate two alumina surfaces with different pore diameters. The former displayed surface pores in the mean range of 16-30 nm, while in the latter pores varied from to 65 to 89 nm. The samples were characterized by Field Emission Scanning Electron Microscopy (FESEM) and Energy Dispersive X-ray spectroscopy (EDX) analysis prior to being tested with pre-osteoblastic MC3T3-E1 cells...
February 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29375990/5-year-follow-up-of-combined-non-topography-guided-photorefractive-keratectomy-and-corneal-collagen-cross-linking-for-keratoconus
#19
Abdulrahman Mohammed Al-Amri
AIM: To evaluate the visual outcomes of simultaneous non-topography guided photorefractive keratectomy (PRK) and corneal collagen cross-linking (CXL) in eyes with keratoconus 5y after the procedure. METHODS: Prospective, interventional, non-randomized, and non-controlled case series design was used. Sixty eyes of 30 patients (16 males and 14 females; age: 21-41y) with mild, non-progressive (stages 1-2) keratoconus were enrolled. Refraction, uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA), flat and steep keratometry readings, and adverse events were evaluated preoperatively and postoperatively...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29340362/synergetic-topography-and-chemistry-cues-guiding-osteogenic-differentiation-in-bone-marrow-stromal-cells-through-erk1-2-and-p38-mapk-signaling-pathway
#20
Xinran Zhang, Haotian Li, Chucheng Lin, Congqin Ning, Kaili Lin
Both the topographic surface and chemical composition modification can enhance rapid osteogenic differentiation and bone formation. Till now, the synergetic effects of topography and chemistry cues guiding biological responses have been rarely reported. Herein, the ordered micro-patterned topography and classically essential trace element of strontium (Sr) ion doping were selected to imitate topography and chemistry cues, respectively. The ordered micro-patterned topography on Sr ion-doped bioceramics was successfully duplicated using the nylon sieve as the template...
January 30, 2018: Biomaterials Science
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