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Collagen Cross-linking

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https://www.readbyqxmd.com/read/27914659/corneal-collagen-cross-linking-a-review-of-its-clinical-applications
#1
K Balparda, M J Maldonado
OBJECTIVE: To perform a literature review of the current clinical applications of corneal collagen cross-linking. METHODS: An exhaustive literature search was made, including the main biomedical databases, and encompassing all years since the introduction of cross-linking in ophthalmology practice. RESULTS: Corneal collagen cross-linking using UVA irradiation and riboflavin is a surgical technique that is currently being optimised, and is supported by a good amount of pre-clinical and clinical studies...
November 30, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27910295/combined-application-of-prophylactic-corneal-cross-linking-and-laser-in-situ-keratomileusis-a-review-of-literature
#2
REVIEW
Tommy C Y Chan, Alex L K Ng, Karen K W Chan, George P M Cheng, Ian Y H Wong, Vishal Jhanji
Laser in-situ keratomileusis (LASIK) is safe and effective laser refractive procedures in treating refractive errors. However, regression of treatment and iatrogenic keratectasia remain to be a major concern, especially in treating thin cornea with high ametropia. Collagen cross-linking (CXL) is an effective method in stopping keratoconus progression through increasing the biomechanical strength of the cornea. Adjuvant cross-linking to refractive procedures can theoretically help prevent regression and reduce the risk of keratectasia development by increasing the mechanical stability of cornea...
December 2, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27895039/region-specific-effect-of-the-decellularized-meniscus-extracellular-matrix-on-mesenchymal-stem-cell-based-meniscus-tissue-engineering
#3
Kazunori Shimomura, Benjamin B Rothrauff, Rocky S Tuan
BACKGROUND: The meniscus is the most commonly injured knee structure, and surgical repair is often ineffective. Tissue engineering-based repair or regeneration may provide a needed solution. Decellularized, tissue-derived extracellular matrices (ECMs) have received attention for their potential use as tissue-engineered scaffolds. In considering meniscus-derived ECMs (mECMs) for meniscus tissue engineering, it is noteworthy that the inner and outer regions of the meniscus have different structural and biochemical features, potentially directing the differentiation of cells toward region-specific phenotypes...
November 28, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27893524/visual-outcomes-after-smile-lasek-and-lasek-combined-with-corneal-collagen-cross-linking-for-high-myopic-correction
#4
Sangyoon Hyun, Seongjun Lee, Jae-Hyung Kim
PURPOSE: To compare the visual and refractive outcomes of small-incision lenticule extraction (SMILE), laser-assisted subepithelial keratomileusis (LASEK), and LASEK combined with corneal collagen cross-linking (LASEK-CXL) surgery for high-degree myopia. METHODS: Medical records of patients with spherical equivalent (SE) greater than -6.00 diopters (D) treated with SMILE, LASEK, and LASEK-CXL were reviewed. Uncorrected distance visual acuity (UCVA), SE, and corneal haze were followed up in the 3 groups for 6 months...
November 23, 2016: Cornea
https://www.readbyqxmd.com/read/27892838/effect-of-bioactive-primers-on-bacterial-induced-secondary-caries-at-the-tooth-resin-interface
#5
G E Kim, A A Leme-Kraus, R Phansalkar, G Viana, C Wu, S-N Chen, G F Pauli, Akb Bedran-Russo
Secondary caries at the tooth-resin interface is the primary reason for replacement of resin composite restorations. The tooth-resin interface is formed by the interlocking of resin material with hydroxyapatite crystals in enamel and collagen mesh structure in dentin. Efforts to strengthen the tooth-resin interface have identified chemical agents with dentin collagen cross-linking potential and antimicrobial activities. The purpose of the present study was to assess protective effects of bioactive primer against secondary caries development around enamel and dentin margins of class V restorations, using an in vitro bacterial caries model...
November 28, 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27885831/a-bioinspired-ultraporous-nanofiber-hydrogel-mimic-of-the-cartilage-extracellular-matrix
#6
Florian A Formica, Ece Öztürk, Samuel C Hess, Wendelin J Stark, Katharina Maniura-Weber, Markus Rottmar, Marcy Zenobi-Wong
A true biomimetic of the cartilage extracellular matrix (ECM) could greatly contribute to our ability to regenerate this tissue in a mechanically demanding, often inflamed environment. Articular cartilage is a composite tissue made of cells and fibrillar proteins embedded in a hydrophilic polymeric meshwork. Here, a polyanionic functionalized alginate is used to mimic the glycosaminoglycan component of the native ECM. To create the fibrillar component, cryoelectrospinning of poly(ε-caprolactone) on a -78 °C mandrel, subsequently treated by O2 plasma, is used to create a stable, ultraporous and hydrophillic nanofiber network...
November 25, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27882004/efficacy-and-safety-of-transepithelial-collagen-cross-linking-for-progressive-keratoconus
#7
Sameer Shahid Ameen, Mohammad Asim Mehboob, Kashif Ali
OBJECTIVE: To evaluate the efficacy and safety of transepithelial (TE) collagen cross-linking (CXL) in patients with progressive keratoconus (KC). METHODS: This Quasi Experimental Study was conducted at PNS Shifa Naval Hospital, Karachi from June 2015 to June 2016. Sixty eyes of 32 patients who underwent TE CXL for progressive KC from June 2015 to June 2016 were analysed to ascertain efficacy and safety of TE CXL procedure. Statistical analysis of the data was done using SPSS version 17...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27878326/a-novel-72-kda-leukocyte-derived-osteoglycin-enhances-the-activation-of-toll-like-receptor-4-and-exacerbates-cardiac-inflammation-during-viral-myocarditis
#8
Marieke Rienks, Anna Papageorgiou, Kristiaan Wouters, Wouter Verhesen, Rick van Leeuwen, Paolo Carai, Georg Summer, Dirk Westermann, Stephane Heymans
BACKGROUND: Viral myocarditis can severely damage the myocardium through excessive infiltration of immune cells. Osteoglycin (OGN) is part of the small leucine-rich repeat proteoglycan (SLRP) family. SLRP's may affect inflammatory and fibrotic processes, but the implication of OGN in cardiac inflammation and the resulting injury upon viral myocarditis is unknown. METHODS AND RESULTS: This study uncovered a previously unidentified 72-kDa variant of OGN that is predominant in cardiac human and mouse samples of viral myocarditis...
November 23, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27876853/collagen-cross-linking-insights-on-the-evolution-of-metazoan-extracellular-matrix
#9
Fernando Rodriguez-Pascual, David Anthony Slatter
Collagens constitute a large family of extracellular matrix (ECM) proteins that play a fundamental role in supporting the structure of various tissues in multicellular animals. The mechanical strength of fibrillar collagens is highly dependent on the formation of covalent cross-links between individual fibrils, a process initiated by the enzymatic action of members of the lysyl oxidase (LOX) family. Fibrillar collagens are present in a wide variety of animals, therefore often being associated with metazoan evolution, where the emergence of an ancestral collagen chain has been proposed to lead to the formation of different clades...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27875930/hybrid-aorta-constructs-via-in-situ-crosslinking-of-poly-glycerol-sebacate-elastomer-within-a-decellularized-matrix
#10
Selcan Guler, Pezhman Hosseinian, Halil Murat Aydin
Decellularization of tissues and organs has high potential to obtain unique conformation and composition as native tissue structure but may result with weaken tissue mechanical strength. In this study poly(glycerol-sebacate) (PGS) elastomers were combined with decellularized aortae fragments to investigate the changes in mechanical properties. PGS prepolymer was synthesized via microwave irradiation then in-situ cross-linked within the decellularized aorta ECM. Tensile strength (σ) values were found comparable as 0...
November 22, 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27873076/the-association-of-testosterone-sex-hormone-binding-globulin-and-insulin-like-growth-factor-1-with-bone-parameters-in-korean-men-aged-50%C3%A2-years-or-older
#11
Hye-Jung Kim, Hyung Suk Koo, Young-Sang Kim, Moon Jong Kim, Kwang-Min Kim, Nam-Seok Joo, Ji-Hee Haam
Testosterone and insulin-like growth factor-1 (IGF-1) are essential factors for the maintenance of bone health in men. However, the results for the association of testosterone and IGF-1 with bone parameters were not consistent in prior studies. We evaluated the relationship of testosterone, sex hormone-binding globulin (SHBG), and IGF-1 with bone mineral density (BMD) and bone turnover markers (BTMs) in Korean men. We enrolled 1227 men aged ≥50 years in this cross-sectional study. Serum levels of total testosterone (TT), SHBG, IGF-1, osteocalcin, and C-terminal cross-linking telopeptide of type I collagen (CTX) were measured...
November 21, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27862940/chitosan-nhac-plga-microsphere-vehicle-for-sustained-release-of-rhbmp-2-and-its-derived-synthetic-oligopeptide-for-bone-regeneration
#12
Yanhui Ji, Mingbo Wang, Weiqiang Liu, Changsheng Chen, Wei Cui, Tingfang Sun, Qingling Feng, Xiaodong Guo
Both of the osteogenic factor and the suitable delivery system in bone tissue engineering are essential for bone regeneration. In this study, we manufactured two kinds of composite vehicles for sustained release of rhBMP-2 and its derived synthetic oligopeptide (Peptide-24, abbreviated as P24) for osteogenesis and bone defect repair. The composite vehicle was based on cross-linked chitosan, nano-hydroxyapatite/collagen (nHAC), and poly (lactide-co-glycolide) acid microsphere. The physicochemical properties of the composite vehicles (abbreviated as CS/nHAC/PLGA-MS) were investigated...
November 10, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27862353/glutaraldehyde-collagen-cross-linking-stabilizes-resin-dentin-interfaces-and-reduces-bond-degradation
#13
Joshua Lee, Camila Sabatini
This study evaluated the stability of resin-dentin interfaces treated with glutaraldehyde-containing agents, and assessed collagen degradation in dentin matrices treated with Gluma. Microtensile bond strength (μTBS) was evaluated 24 h and 6 months after treatment with three desensitizers (Gluma Desensitizer, Gluma Desensitizer Power Gel, and MicroPrime G) and two etch-and-rinse adhesives (Comfort Bond & Desensitizer and iBond TE). Demineralized beams of human dentin were treated with water or Gluma, and the degradation of collagen in these beams was assessed by quantification of the dry mass loss and of the amount of hydroxyproline released from hydrolyzed specimens after 1 or 4 wk...
November 16, 2016: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/27861308/ocular-surface-disease-parameters-after-collagen-cross-linking-for-keratoconus
#14
José I Recalde, Arantxa Acera, Iñaki Rodríguez-Agirretxe, Miguel A Sánchez-Tena, Juan San-Cristóbal, Juan A Durán
PURPOSE: To analyze the variations in tear quantity and quality after corneal collagen cross-linking (CXL) in patients with keratoconus. METHODS: This is a prospective observational study of 24 eyes with keratoconus that underwent epithelium-off CXL. The variables studied were tear film osmolarity, subjective symptoms (Ocular Surface Disease Index), tear breakup time, Schirmer test (SCH) score, tear clearance, fluorescein staining, and lissamine green staining. Variables were determined preoperatively and 3, 6, and 12 months after CXL...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27859600/differences-in-extracellular-matrix-proteins-between-friesian-horses-with-aortic-rupture-unaffected-friesians-and-warmblood-horses
#15
M Ploeg, A Gröne, C H A van de Lest, V Saey, L Duchateau, P Wolsein, K Chiers, R Ducatelle, P R van Weeren, M de Bruijn, C Delesalle
BACKGROUND: Aortic rupture is quite common in Friesian horses unlike in Warmblood horses and a hereditary trait is suspected in Friesians. The aortic connective tissue in affected Friesians shows histological changes such as medial necrosis, elastic fibre fragmentation, mucoid material accumulation and fibrosis with aberrant collagen morphology. However, ultrastructural examination of the collagen fibres of the mid-thoracic aorta was inconclusive when trying to further elucidate the pathogenesis of the disease...
November 16, 2016: Equine Veterinary Journal
https://www.readbyqxmd.com/read/27856711/pulmonary-vascular-collagen-content-not-cross-linking-contributes-to-right-ventricular-pulsatile-afterload-and-overload-in-early-pulmonary-hypertension
#16
Zhijie Wang, David A Schreier, Hinnah Abid, Timothy A Hacker, Naomi C Chesler
Hypoxic pulmonary hypertension (HPH) is associated with pulmonary artery (PA) remodeling and right ventricular (RV) overload. We have previously uncovered collagen-mediated mechanisms of proximal PA stiffening in early HPH by manipulating collagen degradation and crosslinking using a transgenic mouse strain and a potent collagen cross-link inhibitor β-aminopropionitrile (BAPN). However, the roles of collagen in distal PA remodeling, overall RV afterload and RV hypertrophy in HPH remain unknown. Here, we used the same experimental strategy to investigate the impact of pulmonary vascular collagen content and cross-linking on steady and pulsatile RV afterload as well as RV hypertrophy in early HPH...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27856169/pulsed-electromagnetic-field-ameliorates-cartilage-degeneration-by-inhibiting-mitogen-activated-protein-kinases-in-a-rat-model-of-osteoarthritis
#17
Jun Zhou, Yuan Liao, Haitao Xie, Ying Liao, Huifang Liu, Yahua Zeng, Neng Li
OBJECTIVES: We assessed the effects of pulsed electromagnetic field (PEMF) on cartilage degeneration, and expression of mitogen-activated protein kinases (MAPKs) and matrix metalloproteinases (MMPs), in an experimental rat model of osteoarthritis induced by anterior cruciate ligament transection (ACLT). DESIGN: Experimental. SETTING: University animal laboratory. PARTICIPANTS: 30 male Sprague-Dawley rats. MAIN OUTCOME MEASURES: We performed histological examination, enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, to assess cartilage degeneration, urine C-terminal cross-linking telopeptide of type II collagen (CTX-II), and mRNA expression of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (c-Jun), p38, and MMPs...
October 27, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/27851951/viscoplasticity-enables-mechanical-remodeling-of%C3%A2-matrix-by-cells
#18
Sungmin Nam, Joanna Lee, Doug G Brownfield, Ovijit Chaudhuri
Living tissues consist largely of cells and extracellular matrices (ECMs). The mechanical properties of ECM have been found to play a key role in regulating cell behaviors such as migration, proliferation, and differentiation. Although most studies to date have focused on elucidating the impact of matrix elasticity on cell behaviors, recent studies have revealed an impact of matrix viscoelasticity on cell behaviors and reported plastic remodeling of ECM by cells. In this study, we rigorously characterized the plasticity in materials commonly used for cell culture...
November 15, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27832315/bazedoxifene-ameliorates-homocysteine-induced-apoptosis-and-accumulation-of-advanced-glycation-end-products-by-reducing-oxidative-stress-in-mc3t3-e1-cells
#19
Ippei Kanazawa, Tsutomu Tomita, Shun Miyazaki, Eiji Ozawa, Luis A Yamamoto, Toshitsugu Sugimoto
Elevated plasma homocysteine (Hcy) level increases the risk of osteoporotic fracture by deteriorating bone quality. However, little is known about the effects of Hcy on osteoblast and collagen cross-links. This study aimed to investigate whether Hcy induces apoptosis of osteoblastic MC3T3-E1 cells as well as affects enzymatic and nonenzymatic collagen cross-links and to determine the effects of bazedoxifene, a selective estrogen receptor modulator, on the Hcy-induced apoptosis and deterioration of collagen cross-links in the cells...
November 10, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27829051/scleral-cross-linking-using-riboflavin-uva-irradiation-for-the-prevention-of-myopia-progression-in-a-guinea-pig-model-blocked-axial-extension-and-altered-scleral-microstructure
#20
Shuai Liu, Shengjie Li, Bingjie Wang, Xiao Lin, Yi Wu, Hong Liu, Xiaomei Qu, Jinhui Dai, Xingtao Zhou, Hao Zhou
PURPOSE: To develop methods of collagen cross-linking (CXL) in the sclera for the treatment of progressive myopia and to investigate the biomechanical and histological changes that occur in as a result. METHODS: Twenty 14-day-old guinea pigs were divided into 3 groups: the cross-linking group (CL, n = 8), non cross-linking group (NCL, n = 8), and control group (n = 4). The scleras of the right eyes of the guinea pigs in the CL group were surgically exposed and riboflavin was dropped onto the irradiation zone for 20 seconds prior to ultraviolet-A (UVA) irradiation...
2016: PloS One
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