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Collagen Cross-linking

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https://www.readbyqxmd.com/read/29217454/patient-related-barriers-to-rigid-gas-permeable-rgp-lens-wear-among-keratoconus-patients-in-jordan
#1
May M Bakkar, Mera F Haddad, Mohammad Al Qadire
PURPOSE: To assess potential patient-related barriers to rigid gas permeable (RGP) lens wear for vision rehabilitation in a sample of keratoconus (KC) patients in Jordan. METHODS: Barriers for RGP contact lens wear among KC patients were discussed and specified by a focus group which consisted of five optometrists who are involved in contact lens practice. The focus group addressed potential barriers for RGP lens wear from the patient's perspective. The identified barriers were then used to design the final questionnaire used in the study...
December 4, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29215447/cross-sectional-study-of-four-serological-bone-turnover-markers-for-the-risk-assessment-of-medication-related-osteonecrosis-of-the-jaw
#2
Andre Peisker, Gregor F Raschke, Mina D Fahmy, Arndt Guentsch, Korosh Roshanghias, Kai C König, Stefan Schultze-Mosgau
BACKGROUND: Despite the benefits related to the use of bisphosphonates and denosumab, medication-related osteonecrosis of the jaw (MRONJ) is a serious complication. The purpose of this study was to investigate the utility of 4 biochemical markers including serum c-terminal telopeptide cross-link of type I collagen (s-CTX), serum osteocalcin (s-OC), serum parathormon (s-PTH), and serum bone-specific alkaline phosphatase (s-BAP) as useful clinical tools to help assess the risk for MRONJ prior to invasive oral surgery...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29215396/outcomes-of-corneal-cross-linking-correlate-with-cone-specific-lysyl-oxidase-expression-in-patients-with-keratoconus
#3
Rohit Shetty, Nimisha Rajiv Kumar, Natasha Pahuja, Rashmi Deshmukh, KrishnaPoojita Vunnava, Valsala Gopalakrishnan Abilash, Abhijit Sinha Roy, Arkasubhra Ghosh
PURPOSE: To evaluate the correlation of visual and keratometry outcomes after corneal cross-linking (CXL) in patients with keratoconus with cone epithelium-specific gene expression levels. METHODS: Corneal epithelium was obtained from 35 eyes that underwent accelerated CXL (KXLII, 9 mW/cm for 10 min). Using corneal topography, epithelium over the cone and periphery was obtained separately from each subject. The ratio of gene expression for lysyl oxidase (LOX), matrix metalloproteinase 9 (MMP9), bone morphogenic protein 7, tissue inhibitor of metalloproteinase 1, collagen, type I, alpha 1, and collagen, type IV, alpha 1 (COL IVA1) from the cone and peripheral cornea was correlated with the outcome of cross-linking surgery...
December 5, 2017: Cornea
https://www.readbyqxmd.com/read/29209937/sugar-based-collagen-membrane-cross-linking-increases-barrier-capacity-of-membranes
#4
Po-Ju Chia-Lai, Anna Orlowska, Sarah Al-Maawi, Andre Dias, Yunxin Zhang, Xuejiu Wang, Niklas Zender, Robert Sader, C James Kirkpatrick, Shahram Ghanaati
OBJECTIVES: This study examines the permeability and barrier capacity of a sugar cross-linked resorbable collagen membrane ex vivo and in vivo. MATERIALS AND METHODS: In an ex vivo study, injectable platelet-rich fibrin (i-PRF), a peripheral blood-derived human leukocyte-and-platelet-rich plasma was used to analyze membrane permeability. in vivo subcutaneous implantation in Wistar rats (n = 4 per time point and group) was used to investigate the barrier capacity of the membrane...
December 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29204959/insights-into-the-bisphosphonate-holiday-a-preliminary-ftiri-study
#5
A L Boskey, L Spevak, Y Ma, H Wang, D C Bauer, D M Black, A V Schwartz
Bone composition evaluated by FTIRI analysis of iliac crest biopsies from post-menopausal women treated with alendronate for 10 years, continuously or alendronate for 5 years, followed by a 5-year alendronate-holiday, only differed with the discontinued biopsies having increased cortical crystallinity and heterogeneity of acid phosphate substitution and decreased trabecular crystallinity heterogeneity. INTRODUCTION: Bisphosphonates (BP) are the most commonly used and effective drugs to prevent fragility fractures; however, concerns exist that prolonged use may lead to adverse events...
December 5, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29204268/role-of-metastasis-induced-protein-s100a4-in-human-non-tumor-pathophysiologies
#6
REVIEW
Fei Fei, Jie Qu, Chunyuan Li, Xinlu Wang, Yuwei Li, Shiwu Zhang
S100A4, an important member of the S100 family of proteins, is best known for its significant role in promoting cancer progression and metastasis. In addition to its expression in tumors, upregulation of S100A4 expression has been associated with various non-tumor pathophysiology processes. However, the mechanisms underlying the role of S100A4 remain unclear. Activated "host" cells (fibroblasts, immunocytes, vascular cells, among others) secrete S100A4 into the extracellular space in various non-tumor human disorders, where it executes its biological functions by interacting with intracellular target proteins...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29199891/immune-response-of-bovine-sourced-cross-linked-collagen-sponge-for-hemostasis
#7
Lin Zhang, Xufeng Niu, Lei Sun, Zhending She, Rongwei Tan, Wei Wang
A comprehensive immunogenicity scheme is proposed to examine immune response of bovine sourced hemostasis collagen sponge to establish foundation for further researches and decrease the incidence of adverse reaction in clinical trials. Compared with negative control group without any implant, spleen and lymph nodes morphology show no apparent swelling in mice with different doses of collagen sponge implants. Immune cells population, especially lymph nodes cells population, is practically coincident with organs...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29196963/serum-lipid-and-bone-metabolism-effects-of-toremifene-vs-letrozole-as-adjuvant-therapy-for-postmenopausal-early-breast-cancer-patients-results-of-a-multicenter-open-randomized-study
#8
Tadahiko Shien, Hiroyoshi Doihara, Nobuaki Sato, Keisei Anan, Kansei Komaki, Keisuke Miyauchi, Yasuhiro Yanagita, Tomomi Fujisawa, Shoshu Mitsuyama, Chizuko Kanbayashi, Mikihiro Kusama, Morihiko Kimura, Hiromitsu Jinno, Muneaki Sano, Tadashi Ikeda
A prospective randomized phase II trial was conducted to evaluate the time course effects of toremifene (TOR) and letrozole (LET), as adjuvant hormone therapy, on serum lipid profiles and bone metabolism in estrogen receptor (ER)-positive, postmenopausal breast cancer patients.Fifty-four postmenopausal breast cancer patients [ER positive, HER2 negative, T1-2, node metastases (n = 0-3), M0] who had undergone curative resection were enrolled. They were randomized to receive either TOR 40 mg/day or LET 2...
December 1, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29192682/corneal-collagen-cross-linking-in-keratoconus-primum-non-nocere
#9
H Oliphant, M Zarei-Ghanavati, A Shalaby Bardan, A Vasquez-Perez, D O'Brart, C Liu
No abstract text is available yet for this article.
December 1, 2017: Eye
https://www.readbyqxmd.com/read/29187183/low-bone-turnover-in-premenopausal-women-with-type-2-diabetes-mellitus-as-an-early-process-of-diabetes-associated-bone-alterations-a-cross-sectional-study
#10
Dyah Purnamasari, Melisa D Puspitasari, Bambang Setiyohadi, Pringgodigdo Nugroho, Harry Isbagio
BACKGROUND: Individuals with Diabetes Mellitus (DM) are at increased risk for fracture due to the decrease in bone strength and quality. Serum procollagen type I intact N-terminal (P1NP) and serum C-terminal cross-linking telopeptide of type I collagen (CTX) as markers of bone formation and resorption, respectively, have been reported to be decreased in T2DM. It remains unclear whether diabetes-associated alterations in the bone turnover of T2DM individuals are related to the longer duration of the disease or may occur earlier...
November 29, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29182642/elevated-n-telopeptide-as-a-potential-diagnostic-marker-for-bone-metastasis-in-lung-cancer-a-meta-analysis
#11
Boxuan Liu, Yun Zhao, Jingyan Yuan, Lizhong Zeng, Ruiying Sun, Xia Meng, Shuanying Yang
BACKGROUND: Growing evidence indicates that the cross-linked N-telopeptide of type I collagen (NTx) is likely to be involved in the development of bone metastasis among lung cancer patients. We perform a meta-analysis to disclose the correlation between bone metastasis and NTx and also to evaluate its value in diagnosis of bone metastasis (BM) in lung cancer. METHOD: Electronic databases were searched and calculated the weighted mean difference (WMD) with 95% confidence interval (CI) to assess the expression difference of NTx between BM+ and BM- lung cancer patients...
2017: PloS One
https://www.readbyqxmd.com/read/29176563/visualising-the-3d-microstructure-of-stained-and-native-intervertebral-discs-using-x-ray-microtomography
#12
C M Disney, K Madi, A J Bodey, P D Lee, J A Hoyland, M J Sherratt
Intervertebral disc degeneration (IVDD) is linked to low back pain. Microstructural changes during degeneration have previously been imaged using 2D sectioning techniques and 3D methods which are limited to small specimens and prone to inducing artefacts from sample preparation. This study explores micro computed X-ray tomography (microCT) methods with the aim of resolving IVD 3D microstructure whilst minimising sample preparation artefacts. Low X-ray absorption contrast in non-mineralised tissue can be enhanced using staining and phase contrast techniques...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29176450/corneal-cross-linking-with-verteporfin-and-nonthermal-laser-therapy
#13
Saleh A Alageel, Samer N Arafat, Borja Salvador-Culla, Paraskevi E Kolovou, Khadijeh Jahanseir, Adam Kozak, Gavin J C Braithwaite, Joseph B Ciolino
PURPOSE: To test whether verteporfin with a nonthermal laser increases corneal mechanical stiffness and resistance to enzymatic degradation ex vivo. METHODS: Thirty human corneas (n = 5 per group) were treated with verteporfin alone (V), irradiated with nonthermal laser therapy (689 nm) alone (NTL), or received combined treatment of verteporfin with nonthermal laser therapy for 1 sequence (V+NTL1) or 6 sequences (V+NTL6) of 1 minute of NTL exposure. Positive controls were pretreated with 0...
November 22, 2017: Cornea
https://www.readbyqxmd.com/read/29167580/pyridoxamine-improves-survival-and-limits-cardiac-dysfunction-after-mi
#14
Dorien Deluyker, Vesselina Ferferieva, Ronald B Driesen, Maxim Verboven, Ivo Lambrichts, Virginie Bito
Advanced glycation end products (AGEs) play a key role in the progression of heart failure. Whether treatments limiting AGEs formation would prevent adverse left ventricular remodeling after myocardial infarction (MI) remain unknown. We investigated whether pyridoxamine (PM) could limit adverse cardiac outcome in MI. Rats were divided into MI, MI + PM and Sham. Echocardiography and hemodynamic parameters were used to assess cardiac function 8 weeks post-surgery. Total interstitial collagen, collagen I and collagen III were quantified using Sirius Red and polarized light microscopy...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167120/acute-lysyl-oxidase-inhibition-alters-microvascular-function-in-normotensive-but-not-hypertensive-men-and-women
#15
Daniel H Craighead, Huilei Wang, Lakshmi Santhanam, Lacy M Alexander
The Lysyl oxidase (LOX) family of enzymes regulates collagen cross-linking. LOX is upregulated in hypertension, increasing vascular stiffness. In vivo human research is sparse as long-term LOX inhibition in animals causes vascular instability. Our aim was to evaluate the effects of LOX inhibition on cutaneous microvascular function to determine if LOX function was upregulated in hypertensive humans. Four intradermal microdialysis fibers were placed in the forearm of 10 young (age: 24±1 y, MAP: 87±2 mmHg), 10 normotensive (age: 50±2 y, MAP: 84±1 mmHg), and 10 hypertensive (age: 53±2 y, MAP 112±2 mmHg) subjects...
November 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29160595/advanced-anterior-segment-imaging-in-keratoconus-a-review
#16
REVIEW
Akilesh Gokul, Hans R Vellara, Dipika V Patel
Advances in anterior segment imaging have enhanced our ability to detect keratoconus in its early stages and characterise the pathologic changes that occur. Computerised corneal tomography has elucidated the alterations in shape of the anterior and posterior corneal surfaces and alterations in thickness as the disease progresses. Automated screening indices such as the keratoconus screening index were developed to assist in detecting keratoconus in suspicious cases. In vivo assessment of keratoconic corneas has revealed that compromised corneal biomechanics can now be measured clinically...
November 21, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29158188/experimental-use-of-an-acrolein-based-primer-as-collagen-cross-linker-for-dentine-bonding
#17
Tatjana Maravic, Lorenzo Breschi, Allegra Comba, Sandra Ribeiro Cunha, Valeria Angeloni, Cesare Nucci, Josimeri Hebling, David Pashley, Franklin Tay, Annalisa Mazzoni
OBJECTIVES: The objective of the present study was to investigate the long-term effect of 0.01% acrolein (ACR) aqueous solution, employed as an additional primer, on the mechanical durability and enzymatic activity of resin-dentine interfaces created with a simplified etch-and-rinse adhesive. METHODS: Dentine surfaces were etched with 35% phosphoric acid for 15s, rinsed and blot-dried. Specimens were then assigned to: Group 1: dentine pre-treated with 0.01% ACR aqueous solution for 1min and bonded with Adper Scotchbond 1 XT (SB1XT), a 2-step etch-and-rinse adhesive; Group 2: SB1XT was applied on untreated acid-etched dentine (control)...
November 20, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29155964/effects-of-replacing-soybean-meal-with-chickpea-seeds-in-the-diet-on-mechanical-and-thermal-properties-of-tendon-tissue-in-broiler-chicken
#18
S Muszynski, M Kwiecien, M Swietlicki, P Dobrowolski, J Tatarczak, B Gladyszewska
The efficiency of the musculoskeletal system of broiler chickens, in particular during locomotion and in ensuring its supportive function, depends directly on the adequate function and mechanical endurance of soft tissues, including tendons. However, little is known whether the properties of musculoskeletal soft tissues can be influenced by changes of dietary protein. We substituted soybean meal with raw chickpea seeds as the primary protein source in the diet and studied the effects it had on the mechanical and thermal properties of drumstick tendons in broiler Ross 308 chickens...
November 15, 2017: Poultry Science
https://www.readbyqxmd.com/read/29155868/tocilizumab-potentially-prevents-bone-loss-in-patients-with-anticitrullinated-protein-antibody-positive-rheumatoid-arthritis
#19
Yi-Ming Chen, Hsin-Hua Chen, Wen-Nan Huang, Tsai-Ling Liao, Jun-Peng Chen, Wen-Cheng Chao, Ching-Tsai Lin, Wei-Ting Hung, Chia-Wei Hsieh, Tsu-Yi Hsieh, Yi-Hsing Chen, Der-Yuan Chen
Rheumatoid arthritis (RA) is associated with a high risk of osteoporosis and fracture. Interleukin (IL)-6 inhibitors may suppress osteoclast activation. Anticitrullinated protein antibody (ACPA) titers are inversely associated with bone mineral density (BMD). However, the differential effect of ACPA on bone turnover marker (BTM) and BMD changes after IL-6 inhibition remains unclear. This prospective study recruited patients with active RA with inadequate response to methotrexate or biologics. BMD was measured before and after 2-year tocilizumab (TCZ) treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29142546/comparison-of-analgesic-effect-of-preoperative-topical-diclofenac-versus-ketorolac-on-postoperative-pain-after-corneal-collagen-cross-linkage
#20
Murtaza Sameen, Muhammad Saim Khan, Asad Habib, Muhammad Amer Yaqub, Mazhar Ishaq
Objective: To compare post-operative pain relieving effect of topical diclofenac 0.1% versus ketorolac 0.5% in Corneal Collagen Cross Linking (CXL) for patients diagnosed with keratoconus. Methods: This randomized controlled trial was carried out for six months from October 2016 to March 2017. We included young patients having keratoconus with k-readings greater than 47D and central corneal thickness more than 400 microns. All the patients received single dose one drop of topical diclofenac 0...
September 2017: Pakistan Journal of Medical Sciences Quarterly
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