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Collagen Cross-linking

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https://www.readbyqxmd.com/read/28341762/a-prospective-observational-study-on-effect-of-short-term-periodic-steroid-premedication-on-bone-metabolism-in-gastrointestinal-cancer-espresso-01
#1
Michio Nakamura, Atsushi Ishiguro, Tetsuhito Muranaka, Hiraku Fukushima, Satoshi Yuki, Kota Ono, Taichi Murai, Chika Matsuda, Ayane Oba, Kazufumi Itaya, Takayuki Sone, Masataka Yagisawa, Yuta Koike, Ayana Endo, Yoko Tsukuda, Yuji Ono, Takahiko Kudo, Atsushi Nagasaka, Shuji Nishikawa, Yoshito Komatsu
BACKGROUND: A multicenter prospective observational study evaluated the effect of gastrointestinal cancer chemotherapy with short-term periodic steroid premedication on bone metabolism. PATIENTS AND METHODS: Seventy-four patients undergoing chemotherapy for gastrointestinal cancer were studied. The primary endpoints were changes in bone mineral densities (BMDs) and metabolic bone turnover 16 weeks after initiation of chemotherapy. BMDs, measured by dual-energy x-ray absorptiometry, and serum cross-linked N-telopeptides of type I collagen (sNTX), and bone alkaline phosphatase (sBAP) were assessed for evaluation of bone resorption and formation, respectively...
March 24, 2017: Oncologist
https://www.readbyqxmd.com/read/28340021/phenamil-an-amiloride-derivative-restricts-long-bone-growth-and-alters-keeled-sternum-bone-architecture-in-growing-chickens
#2
Tara R Price, Kristin Moncada, Hector Leyva-Jimenez, Kye Won Park, Peter Tontonoz, Rosemary L Walzem
"Broiler-type" chickens are fast-grow-ing, heavy-bodied birds with high demands on bone quality. Phenamil increased mineralization in cultured murine mesenchymal stem cells. Phenamil effects were tested in 2 groups of weight and gender matched day-old broiler chickens (n = 13). Oral administration of 30 mg phenamil/kg body weight d 1 to 13 reduced growth of chicks d 5 to 14 (P = 0.002); with phenamil-treated (PT) chick body weight being 84% of vehicle-treated (VT) chicks' body weight on d 14. Tissues collected on d 15 showed that femur lengths and widths did not differ, but tibias from PT chicks were 6% shorter (P = 0...
March 3, 2017: Poultry Science
https://www.readbyqxmd.com/read/28337057/accelerated-corneal-collagen-cross-linking-in-pediatric-keratoconus-one-year-study
#3
Amani E Badawi
PURPOSE: To evaluate the safety and effectiveness of accelerated corneal collagen crosslinking (CXL) in pediatric keratoconus. DESIGN: Prospective non-randomized observational study. METHODS: 33 eyes of 25 children with keratoconus were included. The corneal epithelium was mechanically removed. Next, riboflavin/hydroxypropyl methylcellulose solution) was applied for 10 min. Accelerated CXL (10 mW/cm(2) for 9 min), was accomplished. Visual acuity, slit lamp examination, refraction, keratometry readings, pachymetry, anterior and posterior elevations, average progression indices, and Q values were recorded...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28336149/the-acl-injury-response-a-collagen-based-analysis
#4
Joshua S Everhart, John H Sojka, Christopher C Kaeding, Alicia L Bertone, David C Flanigan
BACKGROUND: Anterior cruciate ligament (ACL) injuries do not effectively heal. Tendon graft tissue after reconstruction shows rapid tissue turnover and 'ligamentization.' It is unknown whether native torn ACL tissue undergoes significant collagen turnover after injury or is arrested by the intraarticular environment. It is also unknown whether injury mechanism or chronicity affect torn ligament tissue turnover. METHODS: Thirty-three mid-substance ACL biopsies were obtained during primary arthroscopic ACL reconstruction (n=31; nine contact injuries, 22 non-contact injuries, 22 males, 11 females; mean age 28...
March 20, 2017: Knee
https://www.readbyqxmd.com/read/28324004/bone-turnover-is-suppressed-in-insulin-resistance-independent-of-adiposity
#5
K T Tonks, C P White, J R Center, D Samocha-Bonet, J R Greenfield
Context: The contribution of insulin resistance vs. adiposity to bone mineral density (BMD), bone turnover and fractures in humans remains unclear. Objective: Evaluate BMD and bone turnover markers (BTM) in lean (n=18) and overweight/obese individuals with (n=17) and without type 2 diabetes (n=34, deemed insulin-sensitive [Obsensitive, n=15] or insulin-resistant [Obresistant, n=19] by HOMA-IR). Design: Observational study. Outcome measures: Insulin sensitivity assessed by hyperinsulinemic-euglycemic clamp; whole body BMD and fat mass (FM) by DXA; and BTM (osteocalcin [OC], procollagen type-1 propeptide [P1NP] and collagen type-1 cross-linked C-telopeptide [CTx]) fasting and during clamp hyperinsulinemia...
January 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323143/effect-of-age-and-gender-on-serum-periostin-relationship-to-cortical-measures-bone-turnover-and-hormones
#6
Jennifer S Walsh, Fatma Gossiel, Jessica R Scott, Margaret A Paggiosi, Richard Eastell
Periostin is an extracellular matrix protein, and in bone is expressed most highly in the periosteum. It increases bone formation through osteoblast differentiation, cell adhesion, Wnt signalling and collagen cross-linking. We hypothesised that serum periostin would be high at times of life when cortical modeling is active, in early adulthood and in older age, and that it would correlate with cortical bone measures, bone turnover and hormones that regulate cortical modeling. We conducted a cross-sectional observational study of 166 healthy men and women at three skeletal stages; the end of longitudinal growth (16-18years), peak bone mass (30-32years) and older age (over 70years)...
March 16, 2017: Bone
https://www.readbyqxmd.com/read/28322951/initiating-fibro-proliferation-through-interfacial-interactions-of-myoglobin-colloids-with-collagen-in-solution
#7
Madhumitha Dhanasekaran, Aruna Dhathathreyan
This work examines fibro-proliferation through interaction of myoglobin (Mb), a globular protein with collagen, an extracellular matrix fibrous protein. Designed colloids of Mb at pH 4.5 and 7.5 have been mixed with collagen solution at pH 7.5 and 4.5 in different concentrations altering their surface charges. For the Mb colloids, 100-200nm sizes have been measured from Transmission electron micrographs and zeta sizer. CD spectra shows a shift to beta sheet like structure for the protein in the colloids. Interaction at Mb/Collagen interface studied using Dilational rheology, Quartz crystal microbalance with dissipation and Differential Scanning calorimetry show that the perturbation is not only by the charge compensation arising from the difference in pH of the colloids and collagen, but also by the organized assembly of collagen at that particular pH...
March 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28321061/effects-of-denosumab-on-bone-metabolic-markers-and-bone-mineral-density-in-patients-treated-with-glucocorticoids
#8
Masato Sawamura, Atsushi Komatsuda, Masaru Togashi, Hideki Wakui, Naoto Takahashi
Objective We performed a prospective study to determine the efficacy and safety of denosumab on bone metabolic indices and bone mineral density (BMD) in 29 patients receiving long-term glucocorticoids (GCs) who had clinical risk factors for fracture. Methods Among these patients, 16 had systemic lupus erythematosus (SLE), 6 RA, 4 other autoimmune diseases, and 3 renal diseases. All patients received donosumab 60 mg at baseline and 6 months. Serum N-terminal cross-linked telopeptide of type I collagen (NTX) and bone-specific alkaline phosphatase (BAP) levels were measured as bone metabolic indices...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28315501/mechanical-properties-and-biocompatibility-of-in-situ-enzymatically-cross-linked-gelatin-hydrogels
#9
Nada Z Alarake, Patrick Frohberg, Thomas Groth, Markus Pietzsch
OBJECTIVES: Gelatin, a degraded collagen, has been widely used as a scaffolding material in tissue engineering applications. In this work, we aimed at the development of in situ, cross-linking, cytocompatible hydrogels by the use of transglutaminase as a cross-linker for potential application in the regeneration of tissues. METHODS: Hydrogels were prepared from gelatin of different concentrations and bloom degree (175 (G175) or 300 (G300) bloom gelatin) and cross-linked with various amounts of microbial transglutaminase (mTG) at 37°C...
March 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28299638/the-impact-of-aging-on-cardiac-extracellular-matrix
#10
REVIEW
Cesar A Meschiari, Osasere Kelvin Ero, Haihui Pan, Toren Finkel, Merry L Lindsey
Age-related changes in cardiac homeostasis can be observed at the cellular, extracellular, and tissue levels. Progressive cardiomyocyte hypertrophy, inflammation, and the gradual development of cardiac fibrosis are hallmarks of cardiac aging. In the absence of a secondary insult such as hypertension, these changes are subtle and result in slight to moderate impaired myocardial function, particularly diastolic function. While collagen deposition and cross-linking increase during aging, extracellular matrix (ECM) degradation capacity also increases due to increased expression of matrix metalloproteinases (MMPs)...
February 2017: Geroscience
https://www.readbyqxmd.com/read/28299302/cornea-collagen-cross-linking-for-keratoconus-a-comparison-between-accelerated-and-conventional-methods
#11
Hasan Razmjoo, Alireza Peyman, Ali Rahimi, Hoda Jafari Modrek
BACKGROUND: Keratoconus is a progressive degenerative disorder of the cornea in which structural changes in the cornea cause it to become thin and conical in shape. Recently, collagen cross-linking (CXL) has been introduced as an effective intervention in management of progressive keratoconus. Accelerated CXL is a new protocol of this procedure which reduces corneal ultraviolet irradiation exposure time to 5 min. This study aimed to compare visual acuity, keratometry and topographic criteria of keratoconic eyes after conventional and accelerated CXL with a six-month follow-up...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28297584/improvement-of-in-vitro-three-dimensional-cartilage-regeneration-by-a-novel-hydrostatic-pressure-bioreactor
#12
Jie Chen, Zhaoyuan Yuan, Yu Liu, Rui Zheng, Yao Dai, Ran Tao, Huitang Xia, Hairong Liu, Zhiyong Zhang, Wenjie Zhang, Wei Liu, Yilin Cao, Guangdong Zhou
In vitro three-dimensional (3D) cartilage regeneration is a promising strategy for repair of cartilage defects. However, inferior mechanical strength and tissue homogeneity greatly restricted its clinical translation. Simulation of mechanical stress through a bioreactor is an important approach for improving in vitro cartilage regeneration. The current study developed a hydrostatic pressure (HP) bioreactor based on a novel pressure-transmitting mode achieved by slight deformation of a flexible membrane in a completely sealed stainless steel device...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28297026/biomechanical-changes-after-in-vivo-collagen-cross-linking-with-rose-bengal-green-light-and-riboflavin-uva
#13
Nandor Bekesi, Patricia Gallego-Muñoz, Lucía Ibarés-Frías, Pablo Perez-Merino, M Carmen Martinez-Garcia, Irene E Kochevar, Susana Marcos
Purpose: To compare corneal biomechanical properties after in vivo and ex vivo cross-linking (CXL) using rose bengal-green light (RGX) or riboflavin-UVA (UVX). Methods: Corneas of 30 rabbits were treated in vivo by the two CXL modalities monolaterally (Group 1) or bilaterally (Group 2). Rabbits in Group 1 were euthanized 1 month after treatments and in Group 2 two months after treatment. Ex vivo CXL was also performed. Eyes were measured by Scheimpflug air puff corneal deformation imaging (Corvis ST) under constant IOP...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28290599/infrared-microspectroscopic-determination-of-collagen-cross-links-in-articular-cartilage
#14
Lassi Rieppo, Harri T Kokkonen, Katariina A M Kulmala, Vuokko Kovanen, Mikko J Lammi, Juha Töyräs, Simo Saarakkala
No abstract text is available yet for this article.
March 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28282110/collagen-based-photoactive-agent-for-tissue-bonding
#15
Justina Pupkaite, Manuel Ahumada, Sarah Mclaughlin, Maha Temkit, Sura Alaziz, Richard Seymour, Marc Ruel, Irene Kochevar, May Griffith, Erik J Suuronen, Emilio I Alarcon
Using a combination of methacrylated collagen and the photosensitizer rose Bengal, a new light-activated biomimetic material for tissue sutureless bonding was developed. This formulation was cross-linked using green light. In vivo tests in mice demonstrate the suitability of the material for sutureless wound closure.
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28274549/protease-inhibitor-associated-bone-mineral-density-loss-is-related-to-hypothyroidism-and-related-bone-turnover-acceleration
#16
Ei Kinai, Hiroyuki Gatanaga, Daisuke Mizushima, Takeshi Nishijima, Takahiro Aoki, Ikumi Genka, Katsuji Teruya, Kunihisa Tsukada, Yoshimi Kikuchi, Shinichi Oka
BACKGROUND: Clinical and experiments evidence indicate that protease inhibitors (PI) can cause bone mineral density (BMD) loss. However, the mechanism of such loss remains obscure. METHODS: This single-center, cross-sectional study included 184 HIV-infected patients treated with PI who underwent dual-energy X-ray absorptiometry scan. Serum phosphorus, percentage of tubular reabsorption of phosphate (%TRP), thyroid and parathyroid function (iPTH), vitamin D, osteocalcin (OC), urinary deoxypyridinoline (DPD), and urinary cross-linked N-telopeptide of type I collagen (u-NTx) were measured...
March 5, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28266598/treatment-of-rabbit-growth-plate-injuries-with-oriented-ecm-scaffold-and-autologous-bmscs
#17
Wenchao Li, Ruijiang Xu, Jiangxiang Huang, Xing Bao, Bin Zhao
Tissue-engineered technology has provided a promising method for the repair of growth plate injuries using biocompatible and biodegradable scaffolds and appropriate cells. The aim of this study was to fabricate oriented ECM scaffolds to imitate the material and structure of a natural growth plate and to investigate whether BMSCs in a scaffold could prevent the formation of bone bridges in an injured growth plate. We developed a natural, acellular and oriented scaffold derived from a growth plate. The oriented scaffold was fabricated using new freeze-drying technology and by cross-linking the microfilaments in the growth plate...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264133/why-non-contact-tonometry-tests-cannot-evaluate-the-effects-of-corneal-collagen-cross-linking
#18
Ángel Ortillés, José F Rodríguez-Matas, Miguel Á Ariza-Gracia, Gemma Pascual, Begoña Calvo
PURPOSE: To assess the feasibility of characterizing and following up the mechanical behavior of the corneal tissue after corneal cross-linking (CXL) by using a combined mechanical (in vivo indentation and in vitro uniaxial tensile tests) and morphological (immunohisto-chemistry) experimental protocol. METHODS: CXL (3 mW/cm(2); 370 nm) for 20 minutes (total dose 3.6 J/cm(2)) was performed on 12 New Zealand rabbits. The mechanical behavior of the cornea was characterized in small and large strain regimens using an in vivo indentation test with a laboratory device and an in vitro uniaxial tensile test, respectively...
March 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28264131/ex-vivo-study-of-transepithelial-corneal-cross-linking
#19
Andrea Cruzat, Anita N Shukla, Samer N Arafat, Saleh Alageel, Clara Colon, James Chodosh, Joseph B Ciolino
PURPOSE: To perform in vitro assessment of different techniques of transepithelial corneal cross-linking (CXL) and to compare the results to deepithelialized CXL. METHODS: Transepithelial CXL was performed after pre-treatment with or without penetration enhancers (gum cellulose, 0.44% sodium chloride, and 0.01% benzalkonium chloride) for 15 or 60 minutes. Deepithelialized corneas underwent CXL after pretreatment with riboflavin for 15 minutes, according to the Dresden protocol...
March 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28254305/a-novel-hydrogel-of-poloxamer-407-and-chitosan-obtained-by-gamma-irradiation-exhibits-physicochemical-properties-for-wound-management
#20
Gerardo Leyva-Gómez, Erika Santillan-Reyes, E Lima, Abigail Madrid-Martínez, E Krötzsch, D Quintanar-Guerrero, David Garciadiego-Cázares, Alejandro Martínez-Jiménez, M Hernández Morales, Silvestre Ortega-Peña, M E Contreras-Figueroa, G E Cortina-Ramírez, René Fernando Abarca-Buis
Application of polymers cross-linked by gamma irradiation on cutaneous wounds has resulted in the improvement of healing. Chitosan (CH) and poloxamer 407 (P407)-based hydrogels confer different advantages in wound management. To combine the properties of both compounds, a gamma-irradiated mixture of 0.75/25% (w/w) CH and P407, respectively, was obtained (CH-P), and several physical, chemical, and biological analyses were performed. Notably, gamma radiation induced changes in the mixture's thermal behavior, viscosity, and swelling, and exhibited stability at neutral pH...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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