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Collagen Cross-linking

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https://www.readbyqxmd.com/read/29903589/-corneal-collagen-cross-linking-to-treat-infectious-keratitis
#1
REVIEW
R Atia, L Jouve, J Knoeri, C Georgeon, L Laroche, V Borderie, N Bouheraoua
Infectious keratitis are a frequent cause of ocular morbidity. Today, new treatments are necessary to combat the emergence of antibiotic resistant germs. Corneal collagen cross-linking has been suggested to treat corneal infectious (PACK-CXL). Its action would be both antimicrobial and protective for the cornea, increasing its biochemical resistence to proteolytic enzymes. In vivo, PACK-CXL might demonstrate good efficacy against bacterial keratitis, contrary to herpetic keratitis for which it is contraindicated...
June 11, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29895115/-the-clinical-study-of-corneal-cross-linking-with-preserved-corneal-epithelial-flap-in-thin-keratoconic-corneas
#2
J J Sun, X J Huang, W Y Shi, T Wang
Objective: To evaluate the therapeutic effect of corneal collagen cross-linking (CXL) with preserved corneal epithelial flap and isotonic riboflavin for treatment of keratoconus eyes with thin corneas. Methods: Prospective case-control study. Twenty two eyes of 20 patients (16 males and 4 females, with age of 23.5±4.9), who have been diagnosed with progressive keratoeonus and the comeal stroma thickness of whom were less than 400μm (without the epithelium), were included in this study. Corneal collagen crosslinking was performed under preserved corneal epithelial flap (8...
June 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29891536/uncoupling-of-the-itim-receptor-g6b-b-from-the-tyrosine-phosphatases-shp1-and-shp2-disrupts-platelet-homeostasis-in-mice
#3
Mitchell J Geer, Johanna P van Geffen, Piraveen Gopalasingam, Timo Vögtle, Christopher W Smith, Silke Heising, Marijke J E Kuijpers, Bibian M E Tullemans, Gavin E Jarvis, Johannes A Eble, Mark Jeeves, Michael Overduin, Johan W M Heemskerk, Alexandra Mazharian, Yotis A Senis
The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor G6b-B has emerged as a key regulator of platelet homeostasis. However, it remains unclear how it mediates its effects. Tyrosine phosphorylation of the ITIM and immunoreceptor tyrosine-based switch motif (ITSM) within the cytoplasmic tail of G6b-B provides a docking site for SH2 domain-containing protein-tyrosine phosphatases Shp1 and Shp2, which are also critical regulators of platelet production and function. In this study, we investigate the physiological consequences of uncoupling G6b-B from Shp1 and Shp2...
June 11, 2018: Blood
https://www.readbyqxmd.com/read/29873266/multiscale-mechanical-effects-of-native-collagen-cross-linking-in-tendon
#4
Jeremy D Eekhoff, Fei Fang, Spencer P Lake
The hierarchical structure of tendon allows for attenuation of mechanical strain down decreasing length scales. While reorganization of collagen fibers accounts for microscale strain attenuation, cross-linking between collagen molecules contributes to deformation mechanisms at the fibrillar and molecular scales. Divalent and trivalent enzymatic cross-links form during the development of collagen fibrils through the enzymatic activity of lysyl oxidase (LOX). By establishing connections between telopeptidyl and triple-helical domains of adjacent molecules within collagen fibrils, these cross-links stiffen the fibrils by resisting intermolecular sliding...
June 6, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29872930/manufacture-and-characterisation-of-emderm-novel-hierarchically-structured-bio-active-scaffolds-for-tissue-regeneration
#5
Xuxin Lim, Matthew Potter, Zhanfeng Cui, Julian F Dye
There are significant challenges for using emulsion templating as a method of manufacturing macro-porous protein scaffolds. Issues include protein denaturation by adsorption at hydrophobic interfaces, emulsion instability, oil droplet and surfactant removal after protein gelation, and compatible cross-linking methods. We investigated an oil-in-water macro-emulsion stabilised with a surfactant blend, as a template for manufacturing protein-based nano-structured bio-intelligent scaffolds (EmDerm) with tuneable micro-scale porosity for tissue regeneration...
June 5, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29868962/cross-linked-collagen-gels-using-gold-nanoparticles
#6
Katarzyna Slowinska
Cross-linking collagen results in the formation of a collagen matrix that is one of the most widely used biomaterials for applications in drug delivery, tissue engineering, molecular scaffolds, and materials for wound dressing. The properties of the collagen matrix depend on the cross-linking strategy employed. Here we describe the preparation and characterization of a nonfibrillar collagen matrix stabilized by cross-linking with tiopronin-protected, 3-4 nm polyvalent gold nanoparticles.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29863545/changes-in-central-corneal-thickness-with-corneal-collagen-cross-linking
#7
Maddalena De Bernardo, Nicola Rosa
No abstract text is available yet for this article.
May 31, 2018: Cornea
https://www.readbyqxmd.com/read/29862655/comparison-of-corneal-collagen-cross-linking-pack-cxl-and-voriconazole-treatments-in-experimental-fungal-keratitis
#8
Hüseyin Baran Özdemir, Ayşe Kalkancı, Kamil Bilgihan, Pınar Uyar Göçün, Betül Öğüt, Funda Karakurt, Merve Erdoğan
PURPOSE: To compare the antifungal efficacy of corneal collagen cross-linking with photoactivated riboflavin (PACK-CXL) and voriconazole in experimental Fusarium solani and Candida albicans keratitis models. METHODS: Sixty-four corneas of 32 New Zealand rabbits were included and divided into two main groups. Intrastromal injection of Fusarium and Candida suspensions was performed, and it was observed that keratitis was formed on the third day. Both groups were randomly separated into the following four groups: control, PACK-CXL, voriconazole and PACK-CXL combined with voriconazole...
June 4, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29862488/green-tea-polyphenol-epigallocatechin-3-gallate-increases-atherosclerotic-plaque-stability-in-apolipoprotein-e-deficient-mice-fed-a-high-fat-diet
#9
Qiming Wang, Jian Zhang, Yafei Li, Haojie Shi, Hao Wang, Bingrui Chen, Fang Wang, Zemu Wang, Zhijian Yang, Liansheng Wang
BACKGROUND: Epigallocatechin-3-gallate (EGCG), which is the principal component of green tea, has been shown to prevent the formation of atherosclerosis. However, the effect of EGCG on atherosclerotic plaque stability remains unknown. AIM: This study aimed to assess whether EGCG can enhance atherosclerotic plaque stability and to investigate the underlying mechanisms. METHODS: Apolipoprotein E-deficient mice fed a high-fat diet were injected intraperitoneally with EGCG (10 mg/kg ) for 16 weeks...
June 4, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29847492/comparison-of-epithelium-off-versus-transepithelial-corneal-collagen-cross-linking-for-keratoconus-a-systematic-review-and-meta-analysis
#10
Daizong Wen, Benhao Song, Qi Li, Ruixue Tu, Yingying Huang, Qinmei Wang, Colm McAlinden, David OʼBrart, Jinhai Huang
PURPOSE: To systematically compare standard epithelium-off corneal collagen cross-linking (SCXL) and transepithelial corneal collagen cross-linking (TECXL) for treating keratoconus. METHODS: PubMed, EMBASE, the Cochrane Library, the US trial registry (ClinicalTrials.gov), VIP Database, Wanfang Databse, and China National Knowledge Infrastructure searches up to February 2017 were conducted. Primary outcomes were changes at 1 year in uncorrected distance visual acuity, maximum keratometry (Kmax), and mean keratometry (mean K)...
May 25, 2018: Cornea
https://www.readbyqxmd.com/read/29845770/circulating-sclerostin-is-not-suppressed-following-a-single-bout-of-exercise-in-young-men
#11
Katelyn I Guerriere, Julie M Hughes, Erin Gaffney-Stomberg, Jeffery S Staab, Ronald W Matheny
The aim of this study was to determine whether an acute bout of exercise reduces serum sclerostin under diet-controlled conditions that stabilize the parathyroid hormone (PTH)-1,alpha-hydroxylase axis. Fourteen male volunteers (age, 22.1 years ± 4.05; BMI, 27.3 kg/m2  ± 3.8) completed a randomized crossover study in which they performed 10 sets of 10 repetitions of plyometric jumps at 40% of their estimated one-repetition maximum leg press or a nonexercise control period. A calcium-controlled diet (1000 mg/day) was implemented prior to, and throughout each study period...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29844053/thrombospondin-1-promotes-matrix-homeostasis-by-interacting-with-collagen-and-lysyl-oxidase-precursors-and-collagen-cross-linking-sites
#12
Silvia Rosini, Nicholas Pugh, Arkadiusz M Bonna, David J S Hulmes, Richard W Farndale, Josephine C Adams
Fibrillar collagens of the extracellular matrix are critical for tissue structure and physiology; however, excessive or abnormal deposition of collagens is a defining feature of fibrosis. Regulatory mechanisms that act on collagen fibril assembly potentially offer new targets for antifibrotic treatments. Tissue weakening, altered collagen fibril morphologies, or both, are shared phenotypes of mice lacking matricellular thrombospondins. Thrombospondin-1 (TSP1) plays an indirect role in collagen homeostasis through interactions with matrix metalloproteinases and transforming growth factor-β1 (TGF-β1)...
May 29, 2018: Science Signaling
https://www.readbyqxmd.com/read/29808272/carbodiimide-cross-linking-counteracts-the-detrimental-effects-of-gamma-irradiation-on-the-physical-properties-of-collagen-hyaluronan-sponges
#13
Jay M Patel, Ryan C Jackson, Greta L Schneider, Salim A Ghodbane, Michael G Dunn
Collagen-based scaffolds are extensively used in biomaterials and tissue engineering applications. These scaffolds have shown great biocompatibility and versatility, but their relatively low mechanical properties may limit use in orthopaedic load-bearing applications. Moreover, terminal sterilization with gamma irradiation, as is commonly performed with commercial devices, presents concerns over structural integrity and enzymatic stability. Therefore, the goal of this study was to test the hypothesis that EDC/NHS cross-linking (10 mM/5 mM) can protect collagen-hyaluronan sponges from the damaging effects of gamma irradiation...
May 28, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29806415/-dopamine-modified-and-cartilage-derived-morphogenetic-protein-1-laden-polycaprolactone-hydroxyapatite-composite-scaffolds-fabricated-by-three-dimensional-printing-improve-chondrogenic-differentiation-of-human-bone-marrow-mesenchymal-stem-cells
#14
Yan Xu, Bo Wei, Jin Zhou, Qingqiang Yao, Liming Wang, Jian Na
Objective: To prepare dopamine modified and cartilage derived morphogenetic protein 1 (CDMP1) laden polycaprolactone-hydroxyapatite (PCL-HA) composite scaffolds by three-dimensional (3D) printing and evaluate the effect of 3D scaffolds on in vitro chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). Methods: A dimensional porous PCL-HA scaffold was fabricated by 3D printing. Dopamine was used to modify the surface of PCL-HA and then CDMP-1 was loaded into scaffolds...
February 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29804113/optimizing-genipin-concentration-for-corneal-collagen-cross-linking-an-ex-vivo-study
#15
Almutez M Gharaibeh, Virginia Saez, Nerea Garcia, Laurent Bataille, Jorge L Alió
PURPOSE: Studying genipin variable concentrations, treatment durations, and delivery methods as a substance to increase corneal stiffness by inducing corneal collagen cross-linking (CXL). MATERIALS AND METHODS: 100 bovine corneas treated with different genipin concentrations (0.1, 0.5, and 1%) and treatment durations (15 min, 40 min, 2 h, and 3 days) through different delivery methods compared to 10 controls treated with riboflavin/UV. Histology examination, enzymatic digestion with collagenase and thermal differential scanning calorimetry were performed on the different samples...
May 25, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29801150/bmp-and-activin-membrane-bound-inhibitor-regulates-the-extracellular-matrix-in-the-trabecular-meshwork
#16
Humberto Hernandez, J Cameron Millar, Stacy M Curry, Abbot F Clark, Colleen M McDowell
Purpose: The trabecular meshwork (TM) has an important role in the regulation of aqueous humor outflow and IOP. Regulation of the extracellular matrix (ECM) by TGFβ2 has been studied extensively. Bone morphogenetic protein (BMP) and activin membrane-bound inhibitor (BAMBI) has been shown to inhibit or modulate TGFβ2 signaling. We investigate the role of TGFβ2 and BAMBI in the regulation of TM ECM and ocular hypertension. Methods: Mouse TM (MTM) cells were isolated from B6;129S1-Bambitm1Jian/J flox mice, characterized for TGFβ2 and dexamethasone (DEX)-induced expression of fibronectin, collagen-1, collagen-4, laminin, α-smooth muscle actin, cross-linked actin networks (CLANs) formation, and DEX-induced myocilin (MYOC) expression...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29799025/hepatitis-transactivator-protein-x-promotes-extracellular-matrix-modification-through-hif-lox-pathway-in-liver-cancer
#17
Aki Pui-Wah Tse, Karen Man-Fong Sze, Queenie Tsung-Kwan Shea, Elley Yung-Tuen Chiu, Felice Ho-Ching Tsang, David Kung-Chun Chiu, Misty Shuo Zhang, Derek Lee, Iris Ming-Jing Xu, Cerise Yuen-Ki Chan, Hui-Yu Koh, Chun-Ming Wong, Yong-Ping Zheng, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Hepatocellular carcinoma (HCC), accounting for 90% of primary liver cancer, is a lethal malignancy that is tightly associated with chronic hepatitis B virus (HBV) infection. HBV encodes a viral onco-protein, transactivator protein X (HBx), which interacts with proteins of hepatocytes to promote oncogenesis. Our current study focused on the interaction of HBx with a transcription factor, hypoxia-inducible factor-1α (HIF-1α), which is stabilized by low O2 condition (hypoxia) and is found to be frequently overexpressed in HCC intra-tumorally due to poor blood perfusion...
May 25, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29787337/multiple-functions-of-lysyl-oxidase-like-2-in-oral-fibroproliferative-processes
#18
D Saxena, F Mahjour, A D Findlay, E A Mously, A Kantarci, P C Trackman
Gingival overgrowth is a side effect of certain medications, including calcium channel blockers, cyclosporin A, and phenytoin. Phenytoin-induced gingival overgrowth is fibrotic. Lysyl oxidases are extracellular enzymes that are required for biosynthetic cross-linking of collagens, and members of this enzyme family are upregulated in fibrosis. Previous studies in humans and in a mouse model of phenytoin-induced gingival overgrowth have shown that LOXL2 is elevated in the epithelium and connective tissue in gingival overgrowth tissues and not in normal tissues...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29785021/advanced-septa-size-quantitation-determines-the-evaluation-of-histological-fibrosis-outcome-in-chronic-hepatitis-b-patients
#19
Bingqiong Wang, Yameng Sun, Jialing Zhou, Xiaoning Wu, Shuyan Chen, Shanshan Wu, Hui Liu, Tailing Wang, Xiaojuan Ou, Jidong Jia, Hong You
Hepatitis B (HBV)-related fibrosis can be reversed after effective antiviral therapy. However, detailed changes of collagen characteristics during fibrosis regression remain unclear. Paired biopsy samples obtained from chronic hepatitis B patients were imaged with second harmonic generation/two photon excitation fluorescence (SHG/TPEF)-based microscopy to identify and quantify collagen features in portal, septal, and fibrillar areas. According to the changes of Ishak stage and qFibrosis score, a total of 117 patients with paired liver biopsy appeared to have four different outcomes after 78-week antiviral therapy: fast reverse (9%), reverse (63%), stable (15%), or progress (13%) on fibrosis...
May 21, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29780142/diabetes-mellitus-induced-bone-fragility
#20
Ippei Kanazawa, Toshitsugu Sugimoto
Accumulating evidence has shown that the risk of osteoporotic fractures is increased in patients with diabetes mellitus (DM). Thus, DM-induced bone fragility has been recently recognized as a diabetic complication. Because the fracture risk is independent of the reduction in bone mineral density, deterioration of the bone quality may be the main cause of bone fragility. Although its mechanism remains poorly understood, accumulated collagen cross-links of advanced glycation end-products (AGEs) and dysfunctions of osteoblast and osteocyte may be involved...
May 18, 2018: Internal Medicine
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