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Scintigraphy and child

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https://www.readbyqxmd.com/read/27875519/expression-of-somatostatin-receptors-2-and-5-in-circulating-tumour-cells-from-patients-with-neuroendocrine-tumours
#1
Alexa Childs, Clare Vesely, Leah Ensell, Helen Lowe, Tu Vinh Luong, Martyn E Caplin, Christos Toumpanakis, Christina Thirlwell, John A Hartley, Tim Meyer
BACKGROUND: Neuroendocrine tumours (NET) overexpress somatostatin receptors (SSTR) that can be targeted for therapy. Somatostatin receptor expression is routinely measured by molecular imaging but the resolution is insufficient to define heterogeneity. We hypothesised that SSTR expression could be measured on circulating tumour cells (CTCs) and used to investigate heterogeneity of expression and track changes during therapy. METHODS: MCF-7 cells were transfected with SSTR2 or 5 and spiked into donor blood for analysis by CellSearch...
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27540503/incremental-value-of-spect-ct-in-detection-of-meckel-s-diverticulum-in-a-10-year-old-child
#2
Qian Xie, Qingjie Ma, Bin Ji, Shi Gao, Qiang Wen
INTRODUCTION: Meckel's diverticulum is a common congenital abnormality of gastrointestinal tract in children. Planar scintigraphy using Technetium-99m pertechnetate is widely used in the diagnosis of Meckel's diverticulum. Single photon emission computed tomography/computed tomography (SPECT/CT) fusion imaging may help to locate the Meckel's diverticulum lesion. We now present a Meckel's diverticulum case which tends to be missed. CASE DESCRIPTION: The patient was diagnosed with Mecke's diverticulum by planar scintigraphy in 2007...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27534385/total-internal-biliary-diversion-during-liver-transplantation-for-type-1-progressive-familial-intrahepatic-cholestasis-a-novel-approach
#3
V P Mali, A Fukuda, T Shigeta, H Uchida, Y Hirata, T H Rahayatri, H Kanazawa, K Sasaki, J de Ville de Goyet, M Kasahara
LT for PFIC type 1 is often complicated by postoperative diarrhea and recurrent graft steatosis. A 26-month-old female child with cholestatic jaundice, pruritus, diarrhea, and growth retardation revealed total bilirubin 9.1 mg/dL, gamma-glutamyl transpeptidase 64 IU/L, and TBA 295.8 μmol/L. Genetic analysis confirmed ATP8B1 defects. A LT (segment 2, 3 graft) from the heterozygous father was performed. Biliary diversion was performed by a 35-cm jejunum conduit between the graft hepatic duct and the mid-transverse colon...
August 17, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27485064/liver-function-declines-with-increased-age
#4
Kasia P Cieslak, Onno Baur, Joanne Verheij, Roelof J Bennink, Thomas M van Gulik
INTRODUCTION: Age itself is not considered a contraindication for high impact surgery. However, the aging process of the liver remains largely unknown. This study evaluates age-dependent changes in liver function using a quantitative liver function test. METHODS: Between January 2005 and December 2014, 508 patients underwent (99m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) for the assessment of liver function. These included 203 patients with healthy livers (group A) and 57 patients with HCC and Child-Pugh A (group B)...
August 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27442699/extreme-hydronephrosis-due-to-uretropelvic-junction-obstruction-in-infant-case-report
#5
Grażyna Krzemień, Agnieszka Szmigielska, Przemysław Bombiński, Marzena Barczuk, Agnieszka Biejat, Stanisław Warchoł, Teresa Dudek-Warchoł
BACKGROUND: Hydronephrosis is the one of the most common congenital abnormalities of urinary tract. The left kidney is more commonly affected than the right side and is more common in males. AIM OF THE STUDY: To determine the role of ultrasonography, renal dynamic scintigraphy and lowerdose computed tomography urography in preoperative diagnostic workup of infant with extreme hydronephrosis. CASE REPORT: We presented the boy with antenatally diagnosed hydronephrosis...
April 2016: Developmental Period Medicine
https://www.readbyqxmd.com/read/27275365/growth-arrest-line-mimicking-lymphoma-involvement-the-findings-of-99m-tc-mdp-bone-spect-ct-and-serial-bone-scan-in-a-child-with-non-hodgkin-s-lymphoma
#6
Chanwoo Kim, Ji Young Kim, Yun Young Choi, Seunghun Lee, Young-Ho Lee
Growth arrest lines appear as dense sclerotic lines parallel to the growth plate of long bones on radiography. We describe the case of a 9-year-old female with growth arrest lines initially masquerading as lymphoma involvement on (99m)Tc-MDP bone scintigraphy who had been treated with chemotherapy for non-Hodgkin's lymphoma about 3 years previously. Subsequent regional bone SPECT/CT clearly diagnosed the growth arrest lines, and retrograde review of previous bone scintigraphy demonstrated line migration in this patient...
June 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27191796/intrathecal-baclofen-therapy-in-a-child-with-severe-scoliosis-report-of-2-cases
#7
Natsu Sasaki, Hideki Ogiwara
OBJECTIVE: Scoliosis is commonly found in children with cerebral palsy. Many patients with cerebral palsy and scoliosis undergo intrathecal baclofen (ITB) pump placement. The authors report 2 cases with cerebral palsy and severe scoliosis treated with intrathecal baclofen. METHOD: The case of a 7-year-old boy with shunted hydrocephalus required surgical revision of the intrathecal catheter, while the other patient without shunt did not require revision. In the patient with shunted hydrocephalus, after the initial placement of baclofen pump and catheter at Th3 level, spasticity of lower extremities did not improve...
August 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27185180/role-of-yttrium-90-in-the-management-of-unresectable-hepatocellular-carcinoma-and-hepatic-metastases
#8
Vankadari Kousik, Pankaj Promila, Ritu Verma, Arun Gupta
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is the sixth most common cancer and third leading cause of cancer-related death in the world. The management of unresectable HCC and hepatic metastases from various solid tumors is a clinical dilemma. There is paucity of data on the treatment of unresectable HCC and hepatic metastases with yttrium-90 (90Y) radioembolization. METHODS: Thirty patients (mean age; 55.2 years; range 43-82 years) comprising 21 patients with HCC (12 patients have cirrhosis of which 3 patients belong to Child-Pugh class A and 9 patients belong to Child-Pugh class B), 7 patients with metastasis from colorectal cancer, 1 patient with metastasis from melanoma, and 1 patient with metastasis from ovarian carcinoma underwent resin-based 90Y radioembolization between 2013 and 2015 in our study...
May 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/26898031/diuretic-99mtc-dtpa-renography-in-assessment-of-renal-function-and-drainage-in-infants-with-antenatally-detected-hydronephrosis
#9
Marija Radulović, Dragan Pucar, Ljiljana Jauković, Marija Sisić, Zoran Krstić, Boris Ajdinović
BACKGROUND/AIM: The controversy over the postnatal management of infants with antenataly detected hydronephrosis (ANH) still exists. We presented the results of diuretic 99mTc diethylenetriamine pentaacetic acid (DTPA) renography in 30 infants with the antenatal diagnosis of unilateral renal pelvic dilatation. The aim of this study was to assess the renal function determined by the pattern of drainage and split renal function (SRF) on diuretic renography and to correlate these findings with anteroposterior pelvic diameter (APD) estimated by ultrasonography...
December 2015: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/26886916/safety-and-effectiveness-of-percutaneous-cholecystostomy-in-critically-ill-children-who-are-immune-compromised
#10
Carrie M Schaefer, Richard B Towbin, David J Aria, Robin D Kaye
BACKGROUND: Acalculous cholecystitis is known to develop in critically ill patients without cystic duct obstruction. In the past, treatment for acalculous cholecystitis has been cholecystectomy; however, many children who are critically ill are Percutaneous cholecystostomy is likely the procedure of choice in this subgroup of patients. OBJECTIVE: To assess the safety and effectiveness of percutaneous cholecystostomy in critically ill and immune-compromised children with acalculous cholecystitis...
June 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/26761917/giant-bone-island-of-the-tibia-in-a-child
#11
Nikolaos K Sferopoulos
Giant bone islands have been previously diagnosed only in adults. A symptomatic giant bone island of the tibial diaphysis in a 10-year-old boy is presented in this case report. Imaging investigation included plain radiographs, scintigraphy, computed tomography, and magnetic resonance imaging. Although the findings suggested a giant bone island, the appearance of several atypical imaging features necessitated an open biopsy. Histology confirmed the diagnosis of a giant bone island. Its length, which exceeded 10...
January 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/26576531/primary-orbital-neuroblastoma-with-intraocular-extension
#12
Muthukrishnan Vallinayagam, Vasudev Anand Rao, Datta Gulnar Pandian, John Davis Akkara, Niruban Ganesan
Neuroblastoma is an undifferentiated malignancy of primitive neuroblasts. Neuroblastoma is among the most common solid tumors of childhood. Orbital neuroblastoma is typically a metastatic tumor. In this case report, we describe a 2-year-old child with a rapidly progressing orbital tumor. Computed tomography revealed an orbital mass lesion with extraocular and intraocular components. An incisional biopsy was done, and a histopathological examination showed features suggestive of neuroblastoma. Systemic workup including ultrasonography of the abdomen, chest roentgenogram, whole body computed tomography, and bone scintigraphy showed no evidence of systemic involvement...
August 2015: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/26574694/technetium-99m-labelled-red-blood-cells-scintigraphy-and-not-iminodiacetic-acid-cholescintigraphy-facilitates-the-discrimination-of-hepatic-cirrhosis-from-fibrosis
#13
COMPARATIVE STUDY
Vassilios Papantoniou, Pipitsa Valsamaki, Lamprini Skorda, Ioannis Papantoniou, Zisis Delichas, George Zacharakis, Spyridon Michopoulos, Meletios Dimopoulos, Ioannis Koskinas
OBJECTIVE: This pilot study was designed to investigate the efficacy of technetium-99m labelled red blood cells ((99m)Tc-RBC) compared with (99m)Tc-mebrofenin cholescintigraphy ((99m)Tc-MHS), in the diagnosis of hepatic dysfunction at early stages. SUBJECTS AND METHODS: Twenty four patients, 8 with hepatic fibrosis and 16 with cirrhosis, at Child-Pugh stage A to C and 20 age-matched controls were examined by (99m)Tc-RBC and by (99m)Tc-MHS. Dynamic acquisition and static images were semiquantitatively analused by studying the liver-to-heart (L/H) ratio estimated by both the (99m)Tc-RBC and (99m)Tc-MHS methods...
September 2015: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/26557043/asplenia-in-children-with-congenital-heart-disease-as-a-cause-of-poor-outcome
#14
Semiha Bahceci Erdem, Ferah Genel, Baris Erdur, Erhan Ozbek, Nesrin Gulez, Timur Mese
The absence of a spleen is a well-known risk factor for severe bacterial infections, especially due to encapsulated bacteria. Congenital asplenia can be part of multiple congenital abnormalities as in heterotaxy including Ivemark syndrome with congenital anomalies of the heart or great vessels, or it can be isolated, which is extremely rare. In these cases, asplenia is an important factor effecting mortality. In this report, the clinical courses of five children with asplenia and concomitant minor or complex cardiac anomalies are presented...
2015: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/26502655/-scintigraphic-imaging-in-the-diagnosis-of-failed-intrathecal-baclofen-therapy-a-case-report-of-a-7-year-old-boy-with-ventriculoperitoneal-shunt
#15
Akiko Shibata, Mariko Yamamoto, Yu Watanabe, Hiroshi Terashima, Hirofumi Kashii, Masaya Kubota, Nobuhito Morota
Intrathecal baclofen (ITB) therapy is popular for the management of intractable spasticity. In 2007, the indications of ITB therapy expanded to include spasticity of children in Japan. In this report, we assessed the utility of radioisotopic scintigraphy in the diagnosis of failed ITB therapy. A 7-year-old boy with schizencephaly, hydrocephalus, and spastic quadriplegia had an ITB pump implanted. In his infancy, he had undergone ventriculoperitoneal shunt implantation. One month after the ITB operation, the ITB therapeutic effect diminished...
September 2015: No to Hattatsu. Brain and Development
https://www.readbyqxmd.com/read/26496260/pyogenic-sacroiliitis-in-a-13-month-old-child-a-case-report-and-literature-review
#16
REVIEW
Julien Leroux, Leroux Julien, Isabelle Bernardini, Bernardini Isabelle, Lucie Grynberg, Grynberg Lucie, Claire Grandguillaume, Grandguillaume Claire, Paul Michelin, Michelin Paul, Mourad Ould Slimane, Ould Slimane Slimane, Eric Nectoux, Nectoux Eric, François Deroussen, Deroussen François, Richard Gouron, Gouron Richard, Audrey Angelliaume, Angelliaume Audrey, Brice Ilharreborde, Ilharreborde Brice, Mariette Renaux-Petel, Renaux-Petel Mariette
Pyogenic sacroiliitis is exceptional in very young children. Diagnosis is difficult because clinical examination is misleading. FABER test is rarely helpful in very young children. Inflammatory syndrome is frequent. Bone scintigraphy and MRI are very sensitive for the diagnosis. Joint fluid aspiration and blood cultures are useful to identify the pathogen. Appropriate antibiotic therapy provides rapid regression of symptoms and healing. We report the case of pyogenic sacroiliitis in a 13-month-old child.Clinical, biological, and imaging data of this case were reviewed and reported retrospectively...
October 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26486517/pharmacokinetic-and-pharmacodynamic-study-of-tariquidar-xr9576-a-p-glycoprotein-inhibitor-in-combination-with-doxorubicin-vinorelbine-or-docetaxel-in-children-and-adolescents-with-refractory-solid-tumors
#17
Elizabeth Fox, Brigitte C Widemann, Devang Pastakia, Clara C Chen, Sherry X Yang, Diane Cole, Frank M Balis
PURPOSE: P-glycoprotein (Pgp), an ATP-dependent transport protein, confers multidrug resistance in cancer cells. Tariquidar binds and inhibits Pgp. To assess the toxicity, pharmacokinetics (PK), and pharmacodynamics of tariquidar, we conducted a phase I trial of tariquidar in combination with doxorubicin, docetaxel, or vinorelbine in children and adolescents with recurrent or refractory solid tumors. METHODS: Patients less than 19 years of age with refractory or recurrent solid tumors were eligible...
December 2015: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/26417712/123i-mibg-scintigraphy-and-18f-fdg-pet-imaging-for-diagnosing-neuroblastoma
#18
REVIEW
Gitta Bleeker, Godelieve A M Tytgat, Judit A Adam, Huib N Caron, Leontien C M Kremer, Lotty Hooft, Elvira C van Dalen
BACKGROUND: Neuroblastoma is an embryonic tumour of childhood that originates in the neural crest. It is the second most common extracranial malignant solid tumour of childhood.Neuroblastoma cells have the unique capacity to accumulate Iodine-123-metaiodobenzylguanidine (¹²³I-MIBG), which can be used for imaging the tumour. Moreover, ¹²³I-MIBG scintigraphy is not only important for the diagnosis of neuroblastoma, but also for staging and localization of skeletal lesions. If these are present, MIBG follow-up scans are used to assess the patient's response to therapy...
September 29, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26415989/radiofrequency-ablation-under-3d-intraoperative-iso-c-c-arm-navigation-for-the-treatment-of-osteoid-osteomas
#19
Feng Yu, Xiao-Hui Niu, Qing Zhang, Hai-Tao Zhao, Li-Hui Xu, Zhi-Ping Deng
OBJECTIVE: To evaluate the efficacy of intraoperative three-dimensional (3D) Iso-C C-arm-navigated percutaneous radiofrequency ablation (RFA) of osteoid osteomas. METHODS: 35 patients (20 males and 15 females) with osteoid osteomas underwent treatment with intraoperative 3D Iso-C C-arm navigation-guided RFA. The tumour was first biopsied for pathological examination, the core needle was removed and the RFA needle was inserted into the nidus. Post-operative X-rays and CT scans were performed to evaluate the degree of ablation and to assess for recurrence at 3-month follow-up...
2015: British Journal of Radiology
https://www.readbyqxmd.com/read/26390100/hormonal-radiological-np-59-scintigraphy-and-pathological-correlations-in-patients-with-cushing-s-syndrome-due-to-primary-pigmented-nodular-adrenocortical-disease-ppnad
#20
Delphine Vezzosi, Florence Tenenbaum, Laure Cazabat, Frédérique Tissier, Marie Bienvenu, Carmen A Carrasco, Marie Laloi-Michelin, Gaëlle Barrande, Hervé Lefebvre, Sylvie Hiéronimus, Antoine Tabarin, Xavier Bertagna, Paul Legmann, Marie-Christine Vantyghem, Jérôme Bertherat
CONTEXT: Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH-independent Cushing's syndrome that may occur in an isolated form or as part of Carney complex. The diagnosis of this disease can be difficult preoperatively because computed tomography (CT) scan can be normal or suggest unilateral adrenal lesion, which can impede the correct diagnosis of bilateral adrenal disease. OBJECTIVE: The aim of our study was to describe the results of preoperative imaging (adrenal [6β-(131)I]iodomethyl-19-norcholesterol] [NP-59] scintigraphy and standard adrenal CT scan) and their correlations with clinical, pathological, and genetics investigations in patients with PPNAD...
November 2015: Journal of Clinical Endocrinology and Metabolism
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