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Andrés Retamal C, Giancarlo Schiappacasse F, Lizbet Pérez M, Pablo Alvayay Q, Isabel Schild W
Pediatric cancer is the second cause of death in children older than 5 years in our country, after trauma. Positron emission tomography/computed tomography (PET/CT) is a hybrid technique that involves radiation, which has been used for some time in adults and is being progressively imple mented in children. This technique allows morphological and functional assessments of the body with applications in neoplastic and non-neoplastic pathology. Its main role in oncology is in the evaluation and control of lymphomas, sarcomas and neuroblastomas, among others...
December 2017: Revista Chilena de Pediatría
Li-Fen Yang, Liang-Ming Cai, Ming Li, Jin-Tao Liu, Zhao-Ni Wang, Wei-Hao Wang, Qin-Tai Yang, Zhuang-Gui Chen
Objective: To investigate the alterative spectrum and trends of aeroallergens sensitization in children with allergic rhinitis (AR) in Guangzhou, China in the past 10 years. Participants and methods: In this retrospective study, 4,111 children with complaints of nasal hyper-reactivity who visited the Pediatric Department and/or Otolaryngology Department from January 2007 to November 2016 were enrolled. Serum specific immunoglobulin E was measured and positive detection was made in 3,328 patients, who were, therefore, diagnosed with AR...
2018: Therapeutics and Clinical Risk Management
Özlem Ece Demir-Lira, Salomi S Asaridou, Anjali Raja Beharelle, Anna E Holt, Susan Goldin-Meadow, Steven L Small
Gesture is an integral part of children's communicative repertoire. However, little is known about the neurobiology of speech and gesture integration in the developing brain. We investigated how 8- to 10-year-old children processed gesture that was essential to understanding a set of narratives. We asked whether the functional neuroanatomy of gesture-speech integration varies as a function of (1) the content of speech, and/or (2) individual differences in how gesture is processed. When gestures provided missing information not present in the speech (i...
March 8, 2018: Developmental Science
Souheil Hallit, Chantal Raherison, Mirna Waked, Rabih Hallit, Nelly Layoun, Pascale Salameh
BACKGROUND: Few studies used various scales to assess the QOL in Lebanon in general but none was specific to asthma. Our objective was to assess the asthma-related quality of life, using the mini Pediatric Asthma Quality of Life Questionnaire (PAQLQ), in Lebanese asthmatic children, check its validity compared to the original version, and identify clinical and sociodemographic risk factors that might affect these children's QOL. METHODS: This retrospective study included 300 children aged between 7-16 years (51...
March 7, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Andrew M Campbell, Shannon L Thompson, Tara L Harris, Sarah E Wiehe
The risk of harm/injury in homes where intimate partner violence (IPV) occurs is not limited to humans; animals reside in as many as 80% of these homes and may be at substantial risk of suffering severe or fatal injury. Gaining a better understanding of IPV-pet abuse overlap is imperative in more accurately identifying the risks of harm for all individuals and animals residing in these homes. The objectives of this study were to utilize law enforcement officers' observations and IPV victim reports from the scene of the incident to (a) determine the prevalence of pet abuse perpetration among suspects involved in IPV incidents, (b) compare characteristics of IPV incidents and the home environments in which they occur when the suspect has a history of pet abuse with incidents involving suspects with no reported history of pet abuse, and (c) compare IPV incident outcomes involving suspects with a history of pet abuse with those involving suspects with no reported history of pet abuse...
March 1, 2018: Journal of Interpersonal Violence
Emily L Dennis, Talin Babikian, Christopher C Giza, Paul M Thompson, Robert F Asarnow
Traumatic brain injury (TBI) is a significant public health problem in the United States, especially for children and adolescents. Current epidemiological data estimate over 600,000 patients younger than 20 years are treated for TBI in emergency rooms annually. While many patients experience a full recovery, for others there can be long-lasting cognitive, neurological, psychological, and behavioral disruptions. TBI in youth can disrupt ongoing brain development and create added family stress during a formative period...
February 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Sreedharan Thankarajan Arunraj, Girish Kumar Parida, Nishikant Avinash Damle, Saurabh Arora, Sreenivasa Reddy, Dhritiman Chakraborty, Meghna Prabhu, Madhavi Tripathi, Chandrasekhar Bal
Medulloblastoma, also known as cerebellar primitive neuroectodermal tumor, is the most common brain tumor in children and arises in the posterior cranial fossa. We present the case of a patient with desmoplastic type of medulloblastoma, which showed recurrence more than once. When Ga-DOTANOC PET-CT was done, the lesions showed somatostatin receptor expression, opening another potential therapeutic option for this patient.
February 27, 2018: Clinical Nuclear Medicine
Sylvia Villeneuve, Jacob W Vogel, Julie Gonneaud, Alexa Pichet Binette, Pedro Rosa-Neto, Serge Gauthier, Randall J Bateman, Anne M Fagan, John C Morris, Tammie L S Benzinger, Sterling C Johnson, John C S Breitner, Judes Poirier
Importance: Alzheimer disease (AD) develops during several decades. Presymptomatic individuals might be the best candidates for clinical trials, but their identification is challenging because they have no symptoms. Objective: To assess whether a sporadic parental estimated years to symptom onset calculation could be used to identify information about amyloid-β (Aβ) levels in asymptomatic individuals with a parental history of AD dementia. Design, Setting, and Participants: This cohort study analyzed Aβ1-42 in cerebrospinal fluid (CSF) specimens from 101 cognitively normal individuals who had a lumbar puncture as part of the Presymptomatic Evaluation of Novel or Experimental Treatments for Alzheimer Disease (PREVENT-AD) cohort from September 1, 2011, through November 30, 2016 (374 participants were enrolled in the cohort during this period)...
February 26, 2018: JAMA Neurology
Valthierre Nunes de Lima, Gustavo Antonio Correa Momesso, Luara Teixeira Colombo, Gabriel Mulinari-Santos, Cecília Alves de Sousa, Tárik Ocon Braga Polo, Idelmo Rangel Garcia-Júnior, Leonardo Perez Faverani
The frequency of accidents due to dog bite in children is high, and in the most cases, the child already knows the aggressor dog. Patient, 3 years, female, melanoderm, victim of pet dog attack on the right side of the face region. After the physical examination, conscious sedation was performed with the supplementation of oxygen by pediatrics and the suture by oral and maxillofacial surgeon, under local anesthesia with adrenergic vasoconstrictor, with internal points in the muscles using vicryl 4-0 and in the skin with 5-0 nylon; the lesser number of stitches were performed in the lower region of the wound, allowing spontaneous drainage spaces...
February 23, 2018: Journal of Craniofacial Surgery
Sabrina Bressieux-Degueldre, Damien Schaffner, Michaël Hofer, Nicole Sekarski, Federica Vanoni
The cause of Kawasaki disease (KD) is still unknown, but an infectious origin and genetic susceptibility have been suggested. The American Heart Association has changed the guidelines for diagnosis and treatment of KD in 2017. One goal is to better identify patients most at risk, particularly young children with « incomplete » KD. In case of intravenous immunoglobulin resistance, alternative treatments to the traditional use of corticosteroids, such as TNF-alpha inhibitors have been proposed. For all patients with coronary aneurisms, regular assessment of myocardial perfusion is recommended, either with stress echocardiography, MRI, scintigraphy or PET-scan...
February 14, 2018: Revue Médicale Suisse
M Bedolla-Barajas, J Morales-Romero, T I Bedolla-Pulido, T R Bedolla-Pulido, C Meza-López, N A Pulido-Guillén
INTRODUCTION: The association regarding the exposure to pets, especially cats and dogs, and the prevalence of allergic diseases is inconsistent. OBJECTIVE: We analyzed the role played by early exposure to dogs or cats in the prevalence of allergic diseases amongst school-aged children. METHOD: Through a cross-sectional study, we examined 756 children, aged 6-7; these candidates were selected through cluster sampling. We inquired about the exposure that these children had had to dogs and cats, and whether these pets spent most of their time indoors or outdoors during the first year of the child's life...
February 15, 2018: Allergologia et Immunopathologia
Marguerite T Parisi, Jeffrey P Otjen, A Luana Stanescu, Barry L Shulkin
With the exception of radiolabeled monoclonal antibodies, antibody fragments and radiolabeled peptides which have seen little application in the pediatric population, the nuclear medicine imaging procedures used in the evaluation of infection and inflammation are the same for both adults and children. These procedures include (1) either a two- or a three-phase bone scan using technetium-99m methylene diphosphonate; (2) Gallium 67-citrate; (3) in vitro radiolabeled white blood cell imaging (using111 Indium-oxine or99m Technetium hexamethyl-propylene-amine-oxime-labeled white blood cells); and (4) hybrid imaging with18 F-FDG...
March 2018: Seminars in Nuclear Medicine
Hillary Klonoff-Cohen, Ana Navarro, Elizabeth A Klonoff
OBJECTIVES: Every day 43 children are newly diagnosed with cancer. Fortunately, almost 90% of these childhood cancer patients will survive. However, 60-90% of these survivors will experience late effects, health problems that occur months or years after treatment has ended. Late effects could occur as a result of the disease, its treatment, and patient-related factors. The two main objectives of this research are to: 1) Examine the existence of all web-based resources for childhood cancer survivors with acute lymphocytic leukemia which focus on medical and psychological aspects of late effects, and 2) Create an innovative website specifically designed to fill this void...
2018: PloS One
Sarah A Kelley, Shenandoah Robinson, Nathan E Crone, Bruno P Soares
INTRODUCTION: Bottom-of-sulcus focal cortical dysplasias are an under recognized, surgically treatable cause of focal epilepsy. Resection can dramatically reduce the seizure burden for children with refractory epilepsy, or eliminate seizures altogether. MATERIAL AND METHODS: We report the case and present the results of multimodality evaluation of a 15-year-old young man who presented with long-standing partial epilepsy affecting his right leg, which over the years became refractory to therapy...
February 14, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Mitchell A Pet, Ryan Dodge, Babette Siebold, Sara Kinter, Jonathan Perkins, Raymond W Tse
OBJECTIVE: This study compares speech and surgical outcomes in internationally adopted and nonadopted patients undergoing cleft palate repair, and examines the influence of age at initial palatoplasty. DESIGN: Retrospective cohort study setting: Tertiary Care Children's Hospital. PATIENTS: 70 international adoptees and 211 nonadoptees with Veau type III and IV clefts (without associated syndrome) repaired at our institution. OUTCOME MEASURES: Outcomes included VPI, compensatory misarticulations, intelligibility, nasal air emission, oronasal fistula, and secondary speech surgery...
March 2018: Cleft Palate-craniofacial Journal
Martin Mamach, Florian Wilke, Martin Durisin, Frank A Beger, Mareike Finke, Andreas Büchner, Barbara Schultz, Arthur Schultz, Lilli Geworski, Frank M Bengel, Thomas Lenarz, Anke Lesinski-Schiedat, Georg Berding
BACKGROUND: 15O-Water positron emission tomography (PET) enables functional imaging of the auditory system during stimulation via a promontory electrode or cochlear implant, which is not possible using functional magnetic resonance imaging (fMRI). Although PET has been introduced in this context decades ago, its feasibility when performed during general anesthesia has not yet been explored. However, due to a shift to earlier (and bilateral) auditory implantation, the need to study children during general anesthesia appeared, since they are not able to cooperate during scanning...
February 5, 2018: EJNMMI Research
Raheel Ahmed, Luc Rubinger, Cristina Go, James M Drake, James T Rutka, O Carter Snead, Elysa Widjaja
PURPOSE: In patients with medically refractory epilepsy and normal magnetic resonance imaging (MRI), high-resolution dedicated MRI may identify cryptic lesions. The aim of this study was to assess improvement in lesion detection and its impact on clinical management, using additional high-resolution dedicated 3T MRI in children with medically refractory epilepsy who had normal 3T epilepsy protocol MRI. MATERIALS AND METHODS: Children who had resective epilepsy surgery and suspected focal cortical dysplasia (FCD) or normal 3T epilepsy protocol MRI were included...
February 2, 2018: Epilepsy Research
Kathryn A Kerns, Kaela L Stuart-Parrigon, Karin G Coifman, Manfred H M van Dulmen, Amanda Koehn
Despite interest in human-animal interaction, few studies have tested whether the presence of a dog facilitates children's emotional responding. Preadolescents (n = 99) were randomly assigned to complete the Trier Social Stress Test either with or without their pet dog. Children rated their positive and negative affect, and high frequency heart rate variability (HF-HRV) was assessed throughout the session. Children reported higher positive affect when they completed the task with their pet dog, although there were no differences for negative affect or HF-HRV...
February 2018: Social Development
Daniel L Gustafson, Dawn L Duval, Daniel P Regan, Douglas H Thamm
Pet dogs are becoming increasingly recognized as a population with the potential to inform medical research through their treatment for a variety of maladies by veterinary health professionals. This is the basis of the One Health initiative, supporting the idea of collaboration between human and animal health researchers and clinicians to study spontaneous disease processes and treatment in animals to inform human health. Cancer is a major health burden in pet dogs, accounting for approximately 30% of deaths across breeds...
January 26, 2018: Pharmacology & Therapeutics
Juan Carlos Cuevas-Gonzalez, María Elisa Vega-Memíje, Socorro Aída Borges-Yáñez, Erika Rodríguez-Lobato
BACKGROUND: Actinic prurigo (AP) is an idiopathic photodermatosis. Although its initial manifestations can appear in 6 to 8-year-old children, cases are diagnosed later, between the second and fourth decades of life, when the injuries are exacerbated. OBJECTIVE: To identify risk factors associated with clinical manifestations of AP such as skin and mucosal lesions. METHODS: Thirty patients with AP and 60 controls were included in the study, the dependent variable was the presence of skin or labial mucosal lesions, the independent variables were age, sex, solar exposure, living with pets or farm animals, exposure to wood smoke, smoking habit, years smoking, and hours spent per day and per week in contact with people who smoke...
November 2017: Anais Brasileiros de Dermatologia
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