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PET IN CHILDREN

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https://www.readbyqxmd.com/read/28944759/optimization-of-an-ultralow-dose-high-resolution-pediatric-pet-scanner-design-based-on-monolithic-scintillators-with-dual-sided-digital-sipm-readout-a-simulation-study
#1
Ekaterina Mikhaylova, Valerio Tabacchini, Giacomo Borghi, Pieter Mollet, Ester D'Hoe, Dennis R Schaart, Stefaan Vandenberghe
The goal of this simulation study is the performance evaluation and comparison of six potential designs for a time-of-flight PET scanner for pediatric patients of up to about 12 years of age. It is designed to have a high sensitivity and provide high-contrast and high-resolution images. The simulated pediatric PET is a full ring scanner, consisting of 32 × 32 mm<sup>2</sup> monolithic LYSO:Ce crystals coupled to digital silicon photomultiplier (dSiPM) arrays. The six considered designs differ in axial lengths (27...
September 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28942820/domestic-reptiles-as-source-of-zoonotic-bacteria-a-mini-review
#2
REVIEW
Valentina Virginia Ebani
Captive reptiles, always more often present in domestic environment as pets, may harbor and excrete a large variety of zoonotic pathogens. Among them, Salmonella is the most well-known agent, whereas there are very scant data about infections by mycobacteria, chlamydiae and leptospirae in cold-blooded animals. However, the investigations that found antibody reactions and/or the bacteria in samples collected from free-ranging and captive reptiles show that herpetofauna may be involved in the epidemiology of these infections...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28941773/exploring-the-associations-between-parent-reported-biological-indoor-environment-and-airway-related-symptoms-and-allergic-diseases-in-children
#3
Alisa Weber, Nina Fuchs, Susanne Kutzora, Lana Hendrowarsito, Uta Nennstiel-Ratzel, Erika von Mutius, Caroline Herr, Stefanie Heinze
OBJECTIVES: Asthma and allergic rhinitis are diseases which require special attention in childhood. Risk factors for these diseases are manifold and include environmental factors. Previous studies have shown associations between indoor mould and respiratory diseases in children. Besides indoor mould, organic waste storage, potted plants, pets and crowding could influence the microbial indoor environment at home and the respiratory health of children. Our aim was therefore to explore the associations of these factors with airway-related symptoms and respiratory diseases in preschoolers...
September 6, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28940144/erratum-to-racial-differences-in-pet-ownership-in-families-of-children-with-asthma
#4
Shahid I Sheikh, Judy Pitts, Nancy A Ryan-Wenger, Karen S McCoy, Don Hayes
No abstract text is available yet for this article.
June 22, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28939248/early-life-home-environment-and-risk-of-asthma-among-inner-city-children
#5
George T O'Connor, Susan V Lynch, Gordon R Bloomberg, Meyer Kattan, Robert A Wood, Peter J Gergen, Katy F Jaffee, Agustin Calatroni, Leonard B Bacharier, Avrahman Beigelman, Megan T Sandel, Christine C Johnson, Ali Faruqi, Clark Santee, Kei E Fujimura, Douglas Fadrosh, Homer Boushey, Cynthia M Visness, James E Gern
BACKGROUND: Environmental exposures in early life appear to play an important role in the pathogenesis of childhood asthma, but the potentially modifiable exposures that lead to asthma remain uncertain. OBJECTIVE: We sought to identify early-life environmental risk factors for childhood asthma in a birth cohort of high-risk inner-city children. METHODS: We examined the relationship of prenatal and early-life environmental factors to the occurrence of asthma at 7 years of age among 442 children...
September 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28934093/combined-prenatal-pesticide-exposure-and-folic-acid-intake-in-relation-to-autism-spectrum-disorder
#6
Rebecca J Schmidt, Vladimir Kogan, Janie F Shelton, Lora Delwiche, Robin L Hansen, Sally Ozonoff, Claudia C Ma, Erin C McCanlies, Deborah H Bennett, Irva Hertz-Picciotto, Daniel J Tancredi, Heather E Volk
BACKGROUND: Maternal folic acid (FA) protects against developmental toxicity from certain environmental chemicals. OBJECTIVE: We examined combined exposures to maternal FA and pesticides in relation to autism spectrum disorder (ASD). METHODS: Participants were California children born from 2000-2007 who were enrolled in the Childhood Autism Risks from Genetics and the Environment (CHARGE) case-control study at age 2-5 y, were clinically confirmed to have ASD (n=296) or typical development (n=220), and had information on maternal supplemental FA and pesticide exposures...
September 8, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28929965/-a-negleted-bacteria-with-a-case-bartonella-henselae
#7
Kamuran Türker, Bekir Çelebi, Şeyda Andaç, Pınar Bulut, Şenay Yalçın, Saniye Dolhan
Bartonella henselae the causative agent of cat scratch disease (CSD), is a gram-negative, coccobacillus, facultative intracellular bacterium CSD usually presents as a clinical form of benign local lymphadenopathy (LAP) but sometimes it may progress to severe life threatening complications. Despite the fact that CSD is known to be a common disease, which is one of the important causes of local LAPs in the world, there are few publications in our country. For the diagnosis, the clinician should suspect for CSD and has to ask to the patient whether there is a story of cat scratch or not...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28923091/intestinal-parasitic-infections-and-risk-factors-a-cross-sectional-survey-of-some-school-children-in-a-suburb-in-accra-ghana
#8
Akua Obeng Forson, Isaac Arthur, Michael Olu-Taiwo, Kathrine Korkor Glover, Prince Jonathan Pappoe-Ashong, Patrick F Ayeh-Kumi
OBJECTIVE: This study aimed to determine the prevalence and establish some risk factors associated with the acquisition of gastrointestinal parasitic infections in school children in Accra, Ghana. RESULTS: The overall prevalence of intestinal parasitic infection was 15%. Giardia lamblia (10%) and Schistosoma mansoni (1.7%) were the common parasites found. Out of the 15% students postive for intestinal parasites, 13.6% had single parasites and 1.3% had double parasitic infections...
September 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28922191/acr-spr-str-practice-parameter-for-the-performance-of-cardiac-positron-emission-tomography-computed-tomography-pet-ct-imaging
#9
Rathan M Subramaniam, Warren R Janowitz, Geoffrey B Johnson, Martin A Lodge, Marguerite T Parisi, Mark R Ferguson, Jeffrey C Hellinger, Gregory W Gladish, Narainder K Gupta
This clinical practice parameter has been developed collaboratively by the American College of Radiology (ACR), the Society for Pediatric Radiology (SPR), and the Society of Thoracic Radiology (STR). This document is intended to act as a guide for physicians performing and interpreting positron emission tomography-computed tomography (PET/CT) of cardiac diseases in adults and children. The primary value of cardiac PET/CT imaging include evaluation of perfusion, function, viability, inflammation, anatomy, and risk stratification for cardiac-related events such as myocardial infarction and death...
September 15, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28913340/caregiver-reports-of-interactions-between-children-up-to-6-years-and-their-family-dog-implications-for-dog-bite-prevention
#10
Christine Arhant, Andrea Martina Beetz, Josef Troxler
In children up to 6 years, interactions such as interfering with the dog's resources and also benign behaviors (e.g., petting) commonly precede a bite incident with the family dog. Therefore, the aim of the present study was to explore the development of everyday interactions between children up to 6 years and their family dogs and whether parents' attitudes to supervision are related to those interactions. Additionally, we investigated whether behavior of dogs that had lived in the family for longer than the child differed from those that grew up with children...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28910997/paediatric-nuclear-medicine-imaging
#11
Lorenzo Biassoni, Marina Easty
Background: Nuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving. Sources of data: The data presented comes from clinical experience and some milestone papers on the subject...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28891483/emergency-surgery-for-refractory-status-epilepticus
#12
Abhijeet Botre, Vrajesh Udani, Neelu Desai, Spoorthy Jagadish, Milind Sankhe
BACKGROUND: Management of refractory status epilepticus in children is extremely challenging. CASE CHARACTERISTICS: Two children with medically refractory status epilepticus, both of whom had lesional pathology on MRI and concordant data on EEG and PET scan. INTERVENTION: Emergency hemispherotomy performed in both patients. A complete, sustained seizure freedom obtained postoperatively. MESSAGE: Emergency surgery is a treatment option in selected cases of drug refractory status epilepticus with lesional pathology and concordant data...
August 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28888516/effects-of-animal-assisted-activities-on-biobehavioral-stress-responses-in-hospitalized-children-a-randomized-controlled-study
#13
Sandra M Branson, Lisa Boss, Nikhil S Padhye, Thea Trötscher, Alexandra Ward
PURPOSE: This study assessed the effectiveness of animal-assisted activities (AAA) on biobehavioral stress responses (anxiety, positive and negative affect, and salivary cortisol and C-reactive protein [CRP] levels) in hospitalized children. DESIGN AND METHODS: This was a randomized, controlled study. METHOD: Forty-eight participants were randomly assigned to receive a 10-minute AAA (n=24) or a control condition (n=24). Anxiety, positive and negative affect, and levels of salivary biomarkers were assessed before and after the intervention...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28855921/diagnosis-and-treatment-of-hyperinsulinaemic-hypoglycaemia-and-its-implications-for-paediatric-endocrinology
#14
REVIEW
Huseyin Demirbilek, Sofia A Rahman, Gonul Gulal Buyukyilmaz, Khalid Hussain
Glucose homeostasis requires appropriate and synchronous coordination of metabolic events and hormonal activities to keep plasma glucose concentrations in a narrow range of 3.5-5.5 mmol/L. Insulin, the only glucose lowering hormone secreted from pancreatic β-cells, plays the key role in glucose homeostasis. Insulin release from pancreatic β-cells is mainly regulated by intracellular ATP-generating metabolic pathways. Hyperinsulinaemic hypoglycaemia (HH), the most common cause of severe and persistent hypoglycaemia in neonates and children, is the inappropriate secretion of insulin which occurs despite low plasma glucose levels leading to severe and persistent hypoketotic hypoglycaemia...
2017: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/28846790/can-lateral-nasopharyngeal-radiographs-be-used-to-predict-eustachian-tube-dysfunction
#15
Karen Hawley, Neil Vachhani, Samantha Anne
The objective of our case-control study was to determine whether craniofacial features on lateral nasopharyngeal radiographs (LNPRs) can predict eustachian tube dysfunction (ETD). The study included patients seen in the otolaryngology clinic from 2005 to 2011. Patients 0 to 10 years old with pressure equalization tube (PET) placement and LNPR within 6 months were included. Measurements were compared with age-matched controls selected at random to identify craniofacial features associated with ETD. Using receiver operating curve methodology, selected measurements were used to correlate age, craniofacial features, and ETD...
August 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28845428/variations-in-the-prevalence-of-childhood-asthma-and-wheeze-in-medall-cohorts-in-europe
#16
Eleonora P Uphoff, Philippa K Bird, Joseph Maria Antó, Mikel Basterrechea, Andrea von Berg, Anna Bergström, Jean Bousquet, Leda Chatzi, Maria Pia Fantini, Amparo Ferrero, Ulrike Gehring, Davide Gori, Joachim Heinrich, Thomas Keil, Inger Kull, Susanne Lau, Dieter Maier, Isabelle Momas, Silvia Narduzzi, Daniela Porta, Fanny Ranciere, Theano Roumeliotaki, Tamara Schikowski, Henriette A Smit, Marie Standl, Jordi Sunyer, John Wright
While there is evidence for variations in prevalence rates of childhood wheeze and asthma between countries, longitudinal, individual-level data are needed to understand these differences. The aim of this study was to examine variations in prevalence rates of childhood asthma, wheeze and wheeze with asthma in Europe. We analysed datasets from 10 MeDALL (Mechanisms of the Development of ALLergy) cohorts in eight countries, representing 26 663 children, to calculate prevalence rates of wheeze and asthma by child age and wheeze with asthma at age 4 years...
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28841702/prognostic-value-of-fdg-pet-indices-for-the-assessment-of-histological-response-to-neoadjuvant-chemotherapy-and-outcome-in-pediatric-patients-with-ewing-sarcoma-and-osteosarcoma
#17
Clement Bailly, Rodolphe Leforestier, Loic Campion, Estelle Thebaud, Anne Moreau, Francoise Kraeber-Bodere, Thomas Carlier, Caroline Bodet-Milin
PURPOSE: The objective of this retrospective work was to evaluate the prognostic value on histological response and survival of quantitative indices derived from FDG-PET performed before and after chemotherapy (CHT), in a homogeneous pediatric Ewing sarcoma (EWS) and Osteosarcoma (OST) population. METHODS: Thirty-one patients with EWS and 31 with OST were included. All patients were treated with neoadjuvant CHT, and underwent surgery for local control. All patients had FDG-PET at diagnosis and after CHT, prior to surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28832434/perceived-facilitators-and-barriers-to-local-health-department-workers-participation-in-infectious-disease-emergency-responses
#18
Lainie Rutkow, Amy Paul, Holly A Taylor, Daniel J Barnett
CONTEXT: Local health departments play a key role in emergency preparedness and respond to a wide range of threats including infectious diseases such as seasonal influenza, tuberculosis, H1N1, Ebola virus disease, and Zika virus disease. To successfully respond to an infectious disease outbreak, local health departments depend upon the participation of their workforce; yet, studies indicate that sizable numbers of workers would not participate in such a response. The reasons why local health department workers participate, or fail to participate, in infectious disease responses are not well understood...
August 21, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28832001/acquired-epileptic-opercular-syndrome-related-to-a-heterozygous-deleterious-substitution-in-grin2a
#19
Claudine Sculier, Anne-Sophie Tilmant, Xavier De Tiège, Sanda Giurgea, Philippe Paquier, Gabrielle Rudolf, Gaetan Lesca, Patrick Van Bogaert
Epileptic encephalopathies with continuous spike-and-waves during sleep (CSWS) are characterized by cognitive or language impairment, and are occasionally associated with pathogenic variants of the GRIN2A gene. In these disorders, speech dysfunction could be either related to cerebral dysfunction caused by the GRIN2A deleterious variant or intense interictal epileptic activity. Here, we present a patient with apraxia of speech, clearly linked to severity of epilepsy, carrying a GRIN2A variant. A 6-year-old boy developed acute regression of expressive language following epileptic seizures, leading to complete mutism, at which time EEG revealed CSWS...
August 23, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28829352/a-review-of-salmonella-and-squamates-lizards-snakes-and-amphisbians-implications-for-public-health
#20
REVIEW
Harriet Whiley, Michael G Gardner, Kirstin Ross
Globally, there has been an increase in squamates (particularly lizards and snakes) being kept as pets. Additionally, urban spread has resulted in greater human encroachment and interaction with the natural habitat of wild squamates. A potential consequence of increasing human interaction with squamates is the increased potential for disease transfer. This review collates the literature describing clinical salmonellosis cases that were definitively linked to a squamate through testing of the animal and population-based studies which investigate the risk of salmonellosis linked to pet squamates...
August 22, 2017: Pathogens
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