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PET IN CHILDREN

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https://www.readbyqxmd.com/read/29772552/pet-ct-in-the-diagnosis-and-prognosis-of-osteosarcoma
#1
Xiaojuan Zhang, Zhe Guan
Osteosarcoma is an aggressive malignancy that usually occurs in children and young adults, and long-term survival is only about 20% in patients with metastasis or recurrent disease. Traditional non-invasive techniques, such as positron-emission tomography (PET) scanning, magnetic resonance imaging (MRI) or computed tomography (CT) scanning, may not identify single lesions in the early stage or accurately detect small lesions. A novel technique, positron emission tomography/computed tomography (PET/CT), which is widely used in clinical practice, shows more accuracy, sensitivity, and specificity in the diagnosis of osteosarcoma...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29768461/pet-keeping-in-childhood-and-asthma-and-allergy-among-children-in-tianjin-area-china
#2
Shugang Luo, Yuexia Sun, Jing Hou, Xiangrui Kong, Pan Wang, Qingnan Zhang, Jan Sundell
This study aims to find out the relationship between pet keeping in childhood and asthma and allergy among children aged 0-8 years old in Tianjin, China. Parental or guardians reports of 7360 children were analyzed. 1490 (21.6%) families kept pets at the time of the survey (current), among them 4.0% cats, and 14.7% dogs. For the first year of life of children (early), 1196 (18.4%) families kept pets, and among them 3.2% cats, and 13.7% dogs. Exposure to a pet in early childhood significantly increased the risk of current wheeze, current dry cough, and diagnosed rhinitis...
2018: PloS One
https://www.readbyqxmd.com/read/29751416/household-environmental-exposures-during-gestation-and-birth-outcomes-a-cross-sectional-study-in-shanghai-china
#3
Wei Liu, Chen Huang, Jiao Cai, Xueying Wang, Zhijun Zou, Chanjuan Sun
Several studies have reported that certain aspects of the household environments are associated with adverse birth outcomes, but associations have been inconsistent. Few of these studies have been conducted in China. During 2011-2012, we conducted a retrospective cross-sectional study and collected 13,335 parents-reported questionnaires for 4-6-year-olds children in Shanghai, China. We investigated associations of household environmental factors (environmental tobacco smoke (ETS), cooking fuel, dampness, pet-keeping, and home renovation) during gestation with preterm birth (PTB, gestational age<37weeks), low birth weight (LBW, birth weight<2500g), term low birth weight (T-LBW, LBW when the gestational age was ≥37weeks), and small for gestational age (SGA, birth weight<10th percentile of birth weight for gestational age)...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29750397/fdg-pet-ct-in-the-evaluation-of-primary-and-secondary-pancreatic-malignancies
#4
Casey E Bohl, Sara M Federico, Giles W Robinson, Armita Bahrami, Barry L Shulkin
PURPOSE: Primary pancreatic carcinoma and pancreatic metastases are rare in the pediatric population. Pancreatoblastoma is the most common pancreatic malignant tumor in young children and solid-pseudopapillary tumor in teenagers. Pancreatic adenocarcinoma is extremely rare under the age of 40 and is usually associated with underlying genetic abnormalities. Secondary malignancies of the pancreas occur more frequently than primary pancreatic malignancies in children and are most commonly seen with non-Hodgkin lymphomas (NHL) and mesenchymal sarcomas...
May 11, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29729041/wheeze-trajectories-are-modifiable-through-early-life-intervention-and-predict-asthma-in-adolescence
#5
Arthur H Owora, Allan B Becker, Moira Chan-Yeung, Edmond S Chan, Rishma Chooniedass, Clare Ramsey, Wade Ta Watson, Meghan B Azad
BACKGROUND: The objective of this study was to identify developmental trajectories of wheezing using data-driven methodology and examine whether trajectory membership differentially impacts the effectiveness of primary preventive efforts that target modifiable asthma risk factors. METHODS: Secondary analysis of the Canadian Asthma Primary Prevention Study, a multifaceted prenatal intervention among children at high risk for asthma, followed from birth to 15 years...
May 5, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29724189/pretherapeutic-fdg-pet-total-metabolic-tumor-volume-predicts-response-to-induction-therapy-in-pediatric-hodgkin-s-lymphoma
#6
Julian M M Rogasch, Patrick Hundsdoerfer, Frank Hofheinz, Florian Wedel, Imke Schatka, Holger Amthauer, Christian Furth
BACKGROUND: Standardized treatment in pediatric patients with Hodgkin's lymphoma (HL) follows risk stratification by tumor stage, erythrocyte sedimentation rate and tumor bulk. We aimed to identify quantitative parameters from pretherapeutic FDG-PET to assist prediction of response to induction chemotherapy. METHODS: Retrospective analysis in 50 children with HL (f:18; m:32; median age, 14.8 [4-18] a) consecutively treated according to EuroNet-PHL-C1 (n = 42) or -C2 treatment protocol (n = 8)...
May 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29720109/altered-cerebral-glucose-metabolism-normalized-in-a-patient-with-a-pediatric-autoimmune-neuropsychiatric-disorder-after-streptococcal-infection-pandas-like-condition-following-treatment-with-plasmapheresis-a-case-report
#7
A H Nave, P Harmel, R Buchert, L Harms
BACKGROUND: Pediatric autoimmune neuropsychiatric disorder after streptococcal infection (PANDAS) is a specific autoimmune response to group-A streptococcal infections in children and adolescents with a sudden onset of obsessive-compulsive disorders or tic-like symptoms. Cerebral metabolic changes of patients have not yet been observed. CASE PRESENTATION: We present a case of an 18-year old male with a PANDAS-like condition after developing tic-like symptoms and involuntary movements three weeks after cardiac surgery...
May 2, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29692922/-18-f-fdopa-pet-mri-for-monitoring-early-response-to-bevacizumab-in-children-with-recurrent-brain-tumors
#8
Karen Gauvain, Maria Rosana Ponisio, Amy Barone, Michael Grimaldi, Ephraim Parent, Hayden Leeds, Manu Goyal, Joshua Rubin, Jonathan McConathy
Background: Noninvasively predicting early response to therapy in recurrent pediatric brain tumors provides a challenge. 3,4-dihydroxy-6-[18 F]fluoro-L-phenylalanine (18 F-FDOPA) PET/MRI has not been previously studied as a tool to evaluate early response to antiangiogenic therapy in children. The purpose of this study was to evaluate the safety and feasibility of using 18 F-FDOPA PET/MRI to assess response to bevacizumab in children with relapsed brain tumors. Materials and Methods: Six patients with recurrent gliomas (5 low-grade, 1 high-grade) planned to undergo treatment with bevacizumab were enrolled...
March 2018: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29686953/prevalence-and-associated-risk-factors-of-bronchial-asthma-in-children-in-santo-domingo-dominican-republic
#9
Stephanie G Mejias, Kamleshun Ramphul
Background Bronchial asthma is an important health problem worldwide. There is insufficient data on the prevalence of bronchial asthma among school children in Santo Domingo, Dominican Republic. Objective The objective of this study is to assess the prevalence of asthma and its related risk factors among school children in Santo Domingo, Dominican Republic. Materials and methods A cross-sectional study using a modified questionnaire was conducted in Santo Domingo among 600 children aged three to 11 eleven years...
February 20, 2018: Curēus
https://www.readbyqxmd.com/read/29685489/imaging-pediatric-gastrointestinal-stromal-tumor-gist
#10
REVIEW
Moriz Herzberg, Meinrad Beer, Sudha Anupindi, Kurt Vollert, Thomas Kröncke
BACKGROUND: Gastrointestinal stromal tumors (GIST) are extremely rare in children. Imaging plays a key role in staging and monitoring therapy (surgical and with tyrosine kinase inhibitors). The vast majority of articles addressing imaging of GIST base on adults and are based on CT. The subtype "pediatric GIST" - if at all - is only mentioned in a dependent clause. Although the imaging features in children and adults are similar, histology, clinical course and thus imaging approach are different...
March 29, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29672310/significance-of-fdg-pet-hypermetabolism-in-children-with-intractable-focal-epilepsy
#11
Solon Schur, Victoria Allen, Andrew White, David Mirsky, Nicholas Stence, Brent O'Neill, Michael Handler, Roy Dudley, Pramote Laoprasert
BACKGROUND: Interictal 18F-fluorodeoxyglucose-positron emission topography (FDG-PET) hypometabolism is routinely used in the presurgical workup of children with medically intractable epilepsy (MIE). FDG-PET hypermetabolism, however, is rarely seen, and the significance of this finding in the epilepsy workup is not well established. METHODS: We performed a retrospective study of patients who underwent FDG-PET during the presurgical workup of MIE over a 4-year period, between 1 January 2010 and 31 December 2013, at the Children's Hospital Colorado, CO, USA...
April 19, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29667143/diagnostic-performance-of-18-f-fdg-pet-ct-and-whole-body-diffusion-weighted-imaging-with-background-body-suppression-dwibs-in-detection-of-lymph-node-and-bone-metastases-from-pediatric-neuroblastoma
#12
Hiroaki Ishiguchi, Shinji Ito, Katsuhiko Kato, Yusuke Sakurai, Hisashi Kawai, Naotoshi Fujita, Shinji Abe, Atsushi Narita, Nobuhiro Nishio, Hideki Muramatsu, Yoshiyuki Takahashi, Shinji Naganawa
OBJECTIVE: Recent many studies have shown that whole body "diffusion-weighted imaging with background body signal suppression" (DWIBS) seems a beneficial tool having higher tumor detection sensitivity without ionizing radiation exposure for pediatric tumors. In this study, we evaluated the diagnostic performance of whole body DWIBS and 18 F-FDG PET/CT for detecting lymph node and bone metastases in pediatric patients with neuroblastoma. METHODS: Subjects in this retrospective study comprised 13 consecutive pediatric patients with neuroblastoma (7 males, 6 females; mean age, 2...
April 17, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29659063/parents-acceptance-and-their-children-s-choice-of-pet-for-animal-assisted-therapy-a-a-t-in-3-to-12-year-old-children-in-the-dental-operatory-a-questionnaire-based-pilot-study
#13
Nidhi Gupta, Tushar Yadav
AIM: To evaluate the parents' acceptance to therapy pets, child's most favoured pet, child's choice of soft toy as compared to live pet, and child's preference of his own pet versus therapy pet. METHODS: Sixty-two children of age groups 3-6 year, 6-9 year, and 9-12 year were selected. The data from completed questionnaires were statistically analysed and subjected to z test, Chi-squared test with P value<0.05 considered as significant. RESULTS: The consent to the presence of pet was given by 41...
April 16, 2018: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29648910/usefulness-of-positron-emission-tomography-ct-for-diagnosis-of-primary-bone-marrow-lymphoma-in-children
#14
Kyoko Moritani, Naoko Nakano, Sachiko Yonezawa, Fumihiro Ochi, Hisamichi Tauchi, Minenori Eguchi-Ishimae, Mariko Eguchi, Eiichi Ishii, Kozo Nagai
Primary bone marrow lymphoma (PBML) is hard to diagnose in children, due to the difficult identification of malignant cells in bone marrow. The first case, a 5-year-old boy, showed knee swelling with an intermittent fever. The second case, a 12-year-old girl, showed fever of unknown origin without lymphadenopathy or hepatosplenomegaly. In both cases, the diagnosis was not confirmed despite the repeated bone marrow aspirations. Finally, bone marrow aspiration and biopsy at the positive site by positron emission tomography (PET)-CT contributed to definitive diagnosis of PBML...
April 12, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29626122/age-specific-18-f-fdg-image-processing-pipelines-and-analysis-are-essential-for-individual-mapping-of-seizure-foci-in-paediatric-patients-with-intractable-epilepsy
#15
Bianca De Blasi, Anna Barnes, Ilaria Boscolo Galazzo, Chia-Ho Hua, Barry Shulkin, Matthias Koepp, Martin Tisdall
Fluoro-18-deoxyglucose positron emission tomography (FDG-PET) is an important tool for the pre-surgical assessment of children with drug-resistant epilepsy. Standard assessment is carried out visually and this is often subjective and highly user-dependent. Voxel-wise statistics can be used to remove user-dependent biases by automatically identifying areas of significant hypo/hyper-metabolism, associated to the epileptogenic area. In the clinical settings, this analysis is carried out using commercially available software...
April 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29620679/diagnostic-accuracy-of-18f-fdg-pet-ct-in-the-staging-and-assessment-of-response-to-chemotherapy-in-children-with-ewing-sarcoma
#16
Antonio Ruggiero, Valerio Lanni, Alberto Librizzi, Palma Maurizi, Giorgio Attinà, Stefano Mastrangelo, Alessandro Giordano, Riccardo Riccardi
INTRODUCTION: The purpose of this study was to evaluate the potential role of fluorine-18 fluorodeoxyglucose (18F-FDG) positron-emission tomography/computed tomography (PET-CT) in the staging and assessment of chemotherapy response in Ewing sarcoma. MATERIALS AND METHODS: For 13 patients with Ewing sarcoma, whole-body FDG PET-CT was assessed for site of primary disease, disease extent, and response to therapy. Chest CT, localized magnetic resonance imaging or CT of primary site, and bone scintigrams were evaluated for imaging features of the primary lesion and presence or absence of metastatic disease...
May 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29599087/a-novel-method-for-strict-intranasal-delivery-of-non-replicating-rsv-vaccines-in-cotton-rats-and-non-human-primates
#17
Michael P Citron, Manishkumar Patel, Mona Purcell, Shu-An Lin, Daniel J Rubins, Paul McQuade, Cheryl Callahan, Alexa Gleason, Ioan Petrescu, Walter Knapp, Chinedu Orekie, Sai Chamarthy, Zhiyun Wen, Sinoeun Touch, Matthew Pine, Jane Fontenot, Cameron Douglas, Xiaoping Liang, Amy S Espeseth
Respiratory syncytial virus (RSV) is the most common viral cause of bronchiolitis and pneumonia in children twelve months of age or younger and a significant cause of lower respiratory disease in older adults. As various clinical and preclinical candidates advance, cotton rats (Sigmodon hispidus) and non-human primates (NHP) continue to play a valuable role in RSV vaccine development, since both animals are semi-permissive to human RSV (HRSV). However, appropriate utilization of the models is critical to avoid mis-interpretation of the preclinical findings...
March 26, 2018: Vaccine
https://www.readbyqxmd.com/read/29594160/job-related-stress-in-forensic-interviewers-of-children-with-use-of-therapy-dogs-compared-with-facility-dogs-or-no-dogs
#18
Diane Walsh, Mariko Yamamoto, Neil H Willits, Lynette A Hart
Sexually abused children providing essential testimony regarding crimes in forensic interviews now sometimes are provided facility dogs or therapy dogs for comfort. Facility dogs are extensively trained to work with forensic interviewers; when using therapy dogs in interviews, volunteers are the dog handlers. Interviews can impact child welfare workers' mental health causing secondary traumatic stress (STS). To investigate this stress, first data were gathered on stress retrospectively for when interviewers initially started the job prior to working with a dog, and then currently, from forensic interviewers using a facility dog, a therapy or pet dog, or no dog...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29587881/teddi-radiotherapy-delivery-in-deep-inspiration-for-pediatric-patients-a-nopho-feasibility-study
#19
Anni Young Lundgaard, Lisa Lyngsie Hjalgrim, Laura Ann Rechner, Mirjana Josipovic, Morten Joergensen, Marianne Camille Aznar, Anne Kill Berthelsen, Lise Borgwardt, Christoffer Johansen, Annika Loft, Akmal Safwat, Leila Vaalavirta, Lena Specht, Maja Vestmoe Maraldo
BACKGROUND: Radiotherapy (RT) delivered in deep inspiration breath-hold (DIBH) is a simple technique, in which changes in patient anatomy can significantly reduce the irradiation of the organs at risk (OARs) surrounding the treatment target. DIBH is routinely used in the treatment of some adult patients to diminish the risk of late effects; however, no formalized studies have addressed the potential benefit of DIBH in children. METHODS/DESIGN: TEDDI is a multicenter, non-randomized, feasibility study...
March 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29577654/flea-market-finds-and-global-exports-four-multistate-outbreaks-of-human-salmonella-infections-linked-to-small-turtles-united-states-2015
#20
K Gambino-Shirley, L Stevenson, J Concepción-Acevedo, E Trees, D Wagner, L Whitlock, J Roberts, N Garrett, S Van Duyne, G McAllister, B Schick, L Schlater, V Peralta, R Reporter, L Li, H Waechter, T Gomez, J Fernández Ordenes, S Ulloa, C Ragimbeau, J Mossong, M Nichols
Zoonotic transmission of Salmonella infections causes an estimated 11% of salmonellosis annually in the United States. This report describes the epidemiologic, traceback and laboratory investigations conducted in the United States as part of four multistate outbreaks of Salmonella infections linked to small turtles. Salmonella isolates indistinguishable from the outbreak strains were isolated from a total of 143 ill people in the United States, pet turtles, and pond water samples collected from turtle farm A, as well as ill people from Chile and Luxembourg...
March 25, 2018: Zoonoses and Public Health
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