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developmental regression

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https://www.readbyqxmd.com/read/29228154/comparative-transcriptomic-analysis-of-human-placentae-at-term-and-preterm-delivery
#1
Alison G Paquette, Heather M Brockway, Nathan D Price, Louis J Muglia
Purpose: Preterm birth affects 1 out of every 10 infants in the United States, resulting in substantial neonatal morbidity and mortality. Currently, there are few predictive markers and few treatment options to prevent preterm birth. A healthy, functioning placenta is essential to positive pregnancy outcomes. Previous studies have suggested that placental pathology may play a role in preterm birth etiology. Therefore, we tested the hypothesis that preterm placentae may exhibit unique transcriptomic signatures compared to term samples reflective of their abnormal biology leading to this adverse outcome...
December 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29227958/limited-access-to-special-education-services-for-school-aged-children-with-developmental-delay
#2
Erica Twardzik, Ellen Smit, Bridget Hatfield, Michelle C Odden, Alicia Dixon-Ibarra, Megan MacDonald
BACKGROUND: Current policy in Oregon limits eligibility of children diagnosed with developmental delay for school-based services. Due to eligibility definitions, children with developmental delay may face additional barriers transitioning from early intervention/early childhood special education into school-based special education services. AIMS: Examine the relationship between enrollment in school-based special education programs given a change in primary disability diagnosis...
December 8, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29226600/loss-of-skills-and-onset-patterns-in-neurodevelopmental-disorders-understanding-the-neurobiological-mechanisms
#3
Audrey Thurm, Elizabeth M Powell, Jeffrey L Neul, Ann Wagner, Lonnie Zwaigenbaum
Patterns of onset in Autism Spectrum Disorder, including a pattern that includes loss of previously acquired skills, have been identified since the first reports of the disorder. However, attempts to study such "regression" have been limited to clinical studies, that until recently mostly involved retrospective reports. The current report reflects discussion that occurred at an NIMH convened meeting in 2016 with the purpose of bridging clinical autism research with basic and translational work in this area...
December 11, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29225770/sex-determination-mode-does-not-affect-body-or-genital-development-of-the-central-bearded-dragon-pogona-vitticeps
#4
Sarah L Whiteley, Clare E Holleley, Wendy A Ruscoe, Meghan Castelli, Darryl L Whitehead, Juan Lei, Arthur Georges, Vera Weisbecker
Background: The development of male- or female-specific phenotypes in squamates is typically controlled by either temperature-dependent sex determination (TSD) or chromosome-based genetic sex determination (GSD). However, while sex determination is a major switch in individual phenotypic development, it is unknownhow evolutionary transitions between GSD and TSD might impact on the evolution of squamate phenotypes, particularly the fast-evolving and diverse genitalia. Here, we take the unique opportunity of studying the impact of both sex determination mechanisms on the embryological development of the central bearded dragon (Pogona vitticeps)...
2017: EvoDevo
https://www.readbyqxmd.com/read/29221530/parenting-practices-and-associations-with-development-delays-among-young-children-in-dominican-republic
#5
Omolara Thomas Uwemedimo, Afrin Howlader, Giselina Pierret
BACKGROUND: According to the World Health Organization, >200 million children in low- and middle-income countries experience developmental delays. However, household structure and parenting practices have been minimally explored as potential correlates of developmental delay in low- and middle-income countries, despite potential as areas for intervention. OBJECTIVE: The objective of the study was to examine associations of developmental delays with use of World Health Organization-recommended parenting practices among a clinic-based cohort of children aged 6-60 months attending in La Romana, Dominican Republic...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29218767/maternal-communicative-behaviours-and-interaction-quality-as-predictors-of-language-development-findings-from-a-community-based-study-of-slow-to-talk-toddlers
#6
Laura J Conway, Penny A Levickis, Jodie Smith, Fiona Mensah, Melissa Wake, Sheena Reilly
BACKGROUND: Identifying risk and protective factors for language development informs interventions for children with developmental language disorder (DLD). Maternal responsive and intrusive communicative behaviours are associated with language development. Mother-child interaction quality may influence how children use these behaviours in language learning. AIMS: To identify (1) communicative behaviours and interaction quality associated with language outcomes; (2) whether the association between a maternal intrusive behaviour (directive) and child language scores changed alongside a maternal responsive behaviour (expansion); and (3) whether interaction quality modified these associations...
December 7, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29216570/the-effects-of-alcohol-hangover-on-future-drinking-behavior-and-the-development-of-alcohol-problems
#7
Kelly E Courtney, Matthew Worley, Norma Castro, Susan F Tapert
INTRODUCTION: Alcohol hangover experiences in young adulthood have been shown to predict more subsequent alcohol problems. Hangover susceptibility appears to be partially heritable and related to family history of alcohol use disorders. However, very little is known about the developmental course of these associations and whether they are accounted for by an individual's drinking history. The goal of this study is to investigate the prospective and unique relationships between family history of alcohol use disorders, severity of alcohol hangover experiences in adolescence, and later alcohol use and related problems measured over 13years...
November 28, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29215206/once-frail-always-frail-frailty-transitions-in-home-care-users-with-intellectual-and-developmental-disabilities
#8
Lynn Martin, Katherine McKenzie, Hélène Ouellette-Kuntz
AIM: Frailty is understood as a dynamic non-linear process, and used to indicate age-related decline. Recent work has shown that adults with intellectual and developmental disabilities experience higher rates of frailty at much earlier ages than the general population. The present study describes transitions in frailty status (i.e. non-frail, pre-frail, frail) over 1 year, and explores the association between baseline frailty status and worsening/death over time. METHODS: Results are based on secondary analysis of 2893 individuals with intellectual and developmental disabilities receiving community-based home care services in Ontario (Canada)...
December 7, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29215142/cortical-thickness-resting-state-heart-rate-and-heart-rate-variability-in-female-adolescents
#9
Julian Koenig, Peter Parzer, Corinna Reichl, Ayaka Ando, Julian F Thayer, Romuald Brunner, Michael Kaess
Resting state heart rate variability (HRV) is a psychophysiological marker that has gained increasing research interest, in particular in developmental neuroscience. HRV has been shown to be associated with mental and physical health, beyond simple measures of heart rate (HR) and shows inter- and intraindividual variance across aging. Recently, three studies reported on a positive correlation between resting state HRV and cortical thickness in selected regions of interest (ROIs) in adult samples. Structural thickness, HRV, and HR change during the sensitive period of adolescence...
December 7, 2017: Psychophysiology
https://www.readbyqxmd.com/read/29210515/intrafamilial-variability-in-the-clinical-manifestations-of-mucopolysaccharidosis-type-ii-data-from-the-hunter-outcome-survey-hos
#10
Can Ficicioglu, Roberto Giugliani, Paul Harmatz, Nancy J Mendelsohn, Virginie Jego, Rossella Parini
Several cases of phenotypic variability among family members with mucopolysaccharidosis type II (MPS II) have been reported, but the data are limited. Data from patients enrolled in the Hunter Outcome Survey (HOS) were used to investigate intrafamilial variability in male siblings with MPS II. As of July 2015, data were available for 78 patients aged ≥5 years at last visit who had at least one affected sibling (39 sibling pairs). These patients were followed prospectively (i.e., they were alive at enrollment in HOS)...
December 6, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29206797/instability-of-the-hip-joint-after-posterior-acetabular-wall-fracture-independent-risk-factors-remain-elusive
#11
Jay H Patel, Berton R Moed
BACKGROUND: Exact determinants of hip instability have not been established for fractures of the posterior wall of the acetabulum involving ≤50% of the wall. Therefore, examination of the hip under anesthesia (EUA) is routinely performed. Recently, the superior exit point of the fracture has been reported to be an important identifiable risk factor. Pre-existing adult hip dysplasia (developmental dysplasia of the hip [DDH]) is thought to have a similar role. The purpose of this study was to determine if any known radiographic measurements and signs associated with DDH, or any fracture characteristics, are independent risk factors for hip instability after fracture of the posterior wall of the acetabulum...
December 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29206765/the-new-york-sepsis-severity-score-development-of-a-risk-adjusted-severity-model-for-sepsis
#12
Gary S Phillips, Tiffany M Osborn, Kathleen M Terry, Foster Gesten, Mitchell M Levy, Stanley Lemeshow
OBJECTIVES: In accordance with Rory's Regulations, hospitals across New York State developed and implemented protocols for sepsis recognition and treatment to reduce variations in evidence informed care and preventable mortality. The New York Department of Health sought to develop a risk assessment model for accurate and standardized hospital mortality comparisons of adult septic patients across institutions using case-mix adjustment. DESIGN: Retrospective evaluation of prospectively collected data...
December 4, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29205696/teacher-child-relationships-and-classroom-learning-behaviours-of-children-with-developmental-language-disorders
#13
Anna Rhoad-Drogalis, Laura M Justice, Brook E Sawyer, Ann A O'Connell
BACKGROUND: Children with developmental language disorders (DLDs) often struggle with classroom behaviour. No study has examined whether positive teacher-child relationships may act as a protective factor for children with DLDs in that these serve to enhance children's important classroom-learning behaviours. AIMS: To examine the association between the quality of teacher-child relationships and teacher-rated classroom-learning behaviours of children with DLDs in both preschool and kindergarten...
December 5, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29197109/prospective-test-of-the-developmental-propensity-model-of-antisocial-behavior-from-childhood-and-adolescence-into-early-adulthood
#14
Benjamin B Lahey, Quetzal A Class, David H Zald, Paul J Rathouz, Brooks Applegate, Irwin D Waldman
BACKGROUND: The developmental propensity model of antisocial behavior posits that several dispositional characteristics of children transact with the environment to influence the likelihood of learning antisocial behavior across development. Specifically, greater dispositional negative emotionality, greater daring, and lower prosociality-operationally, the inverse of callousness- and lower cognitive abilities are each predicted to increase risk for developing antisocial behavior. METHODS: Prospective tests of key predictions derived from the model were conducted in a high-risk sample of 499 twins who were assessed on dispositions at 10-17 years of age and assessed for antisocial personality disorder (APD) symptoms at 22-31 years of age...
December 2, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29191607/pik3ca-mutation-as-a-distinctive-genetic-feature-of-non-small-cell-lung-cancer-with-chronic-obstructive-pulmonary-disease-a-comprehensive-mutational-analysis-from-a-multi-institutional-cohort
#15
Kenji Sawa, Yasuhiro Koh, Tomoya Kawaguchi, Satoshi Kambayashi, Kazuhisa Asai, Shigeki Mitsuoka, Tatsuo Kimura, Naruo Yoshimura, Naoki Yoshimoto, Akihito Kubo, Hideo Saka, Akihide Matsumura, Hideki Wanibuchi, Nobuyuki Yamamoto, Noritoshi Nishiyama, Kazuto Hirata
OBJECTIVES: Non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD) have been proposed to have a mutual developmental mechanism, but their association has not been fully understood. We aimed to examine the association of the mutational landscape of NSCLC with co-morbid COPD. MATERIALS AND METHODS: A total of 197 surgical specimens of early stage NSCLC were retrospectively collected from two independent sources, namely, the Japan Molecular Epidemiology for Lung Cancer Study and the Osaka City University Hospital cohort from 2010 to 2013...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29190237/impact-of-etiology-on-the-outcome-of-pediatric-rhegmatogenous-retinal-detachment
#16
Ying-Chen Huang, Yen-Chang Chu, Nan-Kai Wang, Chi-Chun Lai, Kuan-Jen Chen, Yih-Shiou Hwang, Wei-Chi Wu
PURPOSE: To evaluate the clinical features and surgical outcomes of rhegmatogenous retinal detachment in pediatric patients and to identify the independent effect of each etiology on the outcome. METHODS: A review of patients younger than 18 years who underwent vitreoretinal surgery was conducted at Chang Gung Memorial Hospital, Taoyuan, between 2008 and 2013. Patients were classified according to etiology. Multivariate logistic regression analysis was performed to evaluate the association between outcomes and each etiologic factor...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29189292/closed-set-speech-discrimination-tests-for-assessing-young-children
#17
Deborah A Vickers, Brian C J Moore, Arooj Majeed, Natalie Stephenson, Hala Alferaih, Thomas Baer, Josephine E Marriage
OBJECTIVE: The main objective of this study is to obtain data assessing normative scores, test-retest reliability, critical differences, and the effect of age for two closed-set consonant-discrimination tests. DESIGN: The two tests are intended for use with children aged 2 to 8 years. The tests were evaluated using normal-hearing children within the appropriate age range. The tests were (1) the closed-set consonant confusion test (CCT) and (2) the consonant-discrimination subtest of the closed-set Chear Auditory Perception Test (CAPT)...
November 16, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29188752/patterns-of-adverse-childhood-experiences-in-juveniles-who-sexually-offended
#18
Steffen Barra, Cornelia Bessler, Markus A Landolt, Marcel Aebi
Juveniles who sexually offended (JSOs) are differentially burdened with adverse childhood experiences (ACEs). The present study used Latent Class Analysis (LCA) to derive subtypes of JSOs according to their patterns of 10 different ACEs. An extensive file analysis of 322 male JSOs ( M = 14.14, SD = 1.94) revealed five subtypes with (a) multiple (9.0%), (b) mainly family related (17.1%), (c) mainly peer related (21.7%), (d) mainly neglectful (18.6%), and (e) little/no (33.5%) ACEs. Differences among ACE subtypes with regard to several offense and victim characteristics (e...
March 1, 2017: Sexual Abuse: a Journal of Research and Treatment
https://www.readbyqxmd.com/read/29187063/nutrition-deficiencies-in-children-with-intestinal-failure-receiving-chronic-parenteral-nutrition
#19
Shweta S Namjoshi, Sarah Muradian, Hannah Bechtold, Laurie Reyen, Robert S Venick, Elizabeth A Marcus, Jorge H Vargas, Laura J Wozniak
BACKGROUND: Home parenteral nutrition (PN) is a lifesaving therapy for children with intestinal failure (IF). Our aims were to describe the prevalence of micronutrient deficiencies (vitamin D, zinc, copper, iron, selenium) in a diverse population of children with IF receiving PN and to identify and characterize risk factors associated with micronutrient deficiencies, including hematologic abnormalities. METHODS: Data were collected on 60 eligible patients through retrospective chart review between May 2012 and February 2015...
February 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29187023/biopsy-proven-hepatocellular-carcinoma-in-a-53-year-old-woman-with-arginase-deficiency
#20
Matthew Koo, Gerald S Lipshutz, Stephen D Cederbaum, Charles Lassman
Arginase 1 deficiency, the least common urea cycle disorder, commonly presents with childhood-onset spastic paraplegia, progressive neurologic impairment, epilepsy, and developmental delay or regression. Biopsy-proven cirrhosis and hepatocellular carcinoma diagnosed via clinical and imaging studies (but without biopsy confirmation) have been previously reported. We report, herein, a case of a 53-year-old woman with arginase 1 deficiency who developed symptoms of "abdominal bloating." Imaging studies (ultrasound and magnetic resonance imaging) demonstrated 2 dominant hepatic masses, measuring 5...
January 1, 2017: Pediatric and Developmental Pathology
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