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https://www.readbyqxmd.com/read/29226640/association-of-paraoxonase-1-polymorphism-and-serum-25-hydroxyvitamin-d-with-the-risk-of-cardiovascular-disease-in-patients-with-rheumatoid-arthritis
#1
Sawsan O Khoja, Yasser El Miedany, Archana P Iyer, Sami M Bahlas, Khadijah S Balamash, Mohamed F Elshal
BACKGROUND: Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality that are not accounted for by traditional risk factors alone. Paraoxonase 1 (PON1) and 25-hydroxyvitamin D have been shown to be involved in the pathogenesis of CV diseases. Objective: This study aimed to investigate PON1 gene polymorphism and serum 25-hydroxyvitamin D concentrations in RA patients, and to determine their association with CV risk in RA. METHODS: Serum samples from 46 RA patients and 45 healthy controls were tested for PON1 R192Q genotypes and serum vitamin D concentrations...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29217620/risk-of-second-malignant-neoplasm-and-mortality-in-patients-with-rheumatoid-arthritis-treated-with-biological-dmards-a-danish-population-based-cohort-study
#2
Lene Dreyer, René L Cordtz, Inger Marie J Hansen, Lars Erik Kristensen, Merete L Hetland, Lene Mellemkjaer
OBJECTIVE: To study the risk of a second malignant neoplasm (SMN) and mortality in patients with rheumatoid arthritis (RA) with a history of a primary cancer diagnosis and treated with biological disease-modifying antirheumatic drugs (bDMARD). METHODS: Among patients with RA (n=15 286) registered in the DANBIO Register during 2000-2011, 1678 had a primary cancer according to the Danish Cancer Registry. HRs for SMN and death were calculated. RESULTS: During follow-up there were 279 patients with RA contributing person-years to the bDMARDs use before their primary cancer diagnosis, 220 to the only after, 92 to the both before and after, while 1203 patients with RA contributed to the non-use strata...
December 7, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29193951/-disseminated-tuberculosis-in-a-patient-with-overlap-syndrome-challenges-in-preventing
#3
Sergio García-Méndez, Lamberto Miguel Caballero-Zavala, Imelda García-Olivera, Fortunato Vásquez-Manuel, Gerardo Pérez-Bustamante, Fabián Tafoya-Ramírez
Patients with autoimmune rheumatic diseases are at increased risk for developing infections and these are associated with increased morbidity and mortality from these diseases, especially in patients with systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis and autoimmune inflammatory myopathies. The objective of this paper is to address the challenges in detecting latent tuberculosis in immunosuppressed patients and the initiation of prophylactic treatment because currently there are no well-defined guidelines indicating what action to take for detection and treatment; so far the available scientific evidence is scarce and some methodological shortcomings...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29193837/weight-change-in-the-early-rheumatoid-arthritis-period-and-risk-for-subsequent-mortality-among-women-with-ra-and-matched-comparators
#4
Jeffrey A Sparks, Shun-Chiao Chang, Uyen-Sa Nguyen, Medha Barbhaiya, Sara K Tedeschi, Bing Lu, David J Kreps, Karen H Costenbader, Yuqing Zhang, Hyon K Choi, Elizabeth W Karlson
OBJECTIVE: We investigated whether weight change during the early RA period was associated with subsequent mortality and evaluated for an RA-specific effect. METHODS: We identified incident RA during the Nurses' Health Study (1976-2016) and created a comparison cohort, matching each RA case with up to 10 non-RA comparators by age and year of RA diagnosis (index date). To capture weight change around the early RA period ("peri-RA/index"), we used weight measures 2-4 years before and after index date...
November 30, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29155735/quantification-of-monocyte-transmigration-and-foam-cell-formation-from-individuals-with-chronic-inflammatory-conditions
#5
Thomas A Angelovich, Anna C Hearps, Anna Maisa, Theodoros Kelesidis, Anthony Jaworowski
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Atherosclerosis, a leading cause of CAD, is initiated by the transmigration of innate immune monocytes to inflammatory sites of deposited lipid called fatty streaks, which are present in arterial walls of medium to large arteries. The key pathogenic feature of lesions at this early stage of atherosclerosis is the maturation of monocytes which migrate into arteries to form foam cells or lipid-laden macrophages. Considerable evidence supports the hypothesis that risk of atherosclerosis is increased by chronic inflammatory conditions accompanying diseases such as rheumatoid arthritis and HIV, as well as general ageing, and that this risk is predicted by monocyte activation...
October 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29141572/a-clinical-update-and-global-economic-burden-of-rheumatoid-arthritis
#6
Syed Ali Fazal, Mohammad Khan, Shamima Easmin Nishi, Fahmida Alam, Nowshin Zarin, Mohammad Tariful Bari, Ghulam Md Ashraf
Rheumatoid arthritis (RA) is a predominant inflammatory autoimmune disorder. The incidence and prevalence of RA is increasing with considerable morbidity and mortality worldwide. The pathophysiology of RA has become clearer due to many significant research outputs during the last two decades. Many inflammatory cytokines involved in RA pathophysiology and the presence of autoantibodies are being used as potential biomarkers via the use of effective diagnostic techniques for the early diagnosis of RA. Currently, several disease-modifying anti-rheumatic drugs are being prescribed targeting RA pathophysiology, which have shown significant contributions in improving the disease outcomes...
November 14, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29138606/mortality-in-italian-patients-with-rheumatoid-arthritis-evidence-for-a-low-mortality-rate-from-cancer-and-infections-in-patients-followed-up-at-a-tertiary-center
#7
Daniela Iacono, Serena Fasano, Virginia D'Abrosca, Ilenia Pantano, Gabriele Valentini
Objectives: Mortality in patients with rheumatoid arthritis (RA) has never been investigated in Italy. This study is devoted to investigating all the distinct causes of mortality in Italian RA patients. Methods: Clinical charts of patients consecutively admitted to an Italian tertiary center, from January 1, 2008 to December 31, 2014, were reviewed. Mortality rates (incidence mortality rate [IMR] and standardized mortality rate [SMR]) and causes of death as assessed at December 31, 2015, were registered...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29120746/segmented-filamentous-bacteria-provoke-lung-autoimmunity-by-inducing-gut-lung-axis-th17-cells-expressing-dual-tcrs
#8
C Pierce Bradley, Fei Teng, Krysta M Felix, Teruyuki Sano, Debdut Naskar, Katharine E Block, Haochu Huang, Kenneth S Knox, Dan R Littman, Hsin-Jung Joyce Wu
Lung complications are a major cause of rheumatoid arthritis-related mortality. Involvement of gut microbiota in lung diseases by the gut-lung axis has been widely observed, but the underlying mechanism remains mostly unknown. Using an autoimmune arthritis model, we show that a constituent of the gut microbiota, segmented filamentous bacteria (SFB), distantly provoke lung pathology. SFB induce autoantibodies in lung during the pre-arthritic phase, and SFB-dependent lung pathology requires the T helper 17 (Th17) responses...
November 8, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29119259/rheumatoid-arthritis-associated-interstitial-lung-disease-current-concepts
#9
REVIEW
Yoel Brito, Marilyn K Glassberg, Dana P Ascherman
PURPOSE OF REVIEW: Among the many extra-articular complications of rheumatoid arthritis (RA), interstitial lung disease (ILD) contributes significantly to morbidity and mortality. Prevalence estimates for RA-ILD vary widely depending on the specific clinical, radiographic, and functional criteria used to establish the diagnosis. A key unresolved issue is whether early, subclinical forms of RA-ILD represent a precursor to end stage, fibrotic lung disease. Based on uncertainties surrounding the natural history of RA-ILD, incomplete understanding of underlying disease pathogenesis, and lack of controlled clinical trials, evidence-based therapeutic strategies remain largely undefined...
November 9, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29118859/pleuropulmonary-manifestation-in-patients-with-rheumatoid-arthritis-in-saudi-arabia
#10
Omer S B Alamoudi, Suzan Mansour Attar
BACKGROUND AND OBJECTIVES: Pleuropulmonary (PP) involvement in rheumatoid arthritis (RA) is associated with high morbidity and mortality. Nevertheless, limited data are available regarding lung complications in the Middle East, especially in Saudi Arabia. The objectives of the current study were to determine the prevalence of PP manifestations and to identify the associated risk factors. METHODS: This was a retrospective study involving 419 patients diagnosed at a tertiary center over a 12...
October 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29107339/comorbidities-in-rosacea-a-systematic-review-and-update
#11
REVIEW
Roger Haber, Maria El Gemayel
BACKGROUND: Rosacea is linked to abnormalities of cutaneous vasculature and dysregulation of the inflammatory response. Recent reports on rosacea have shown a significant association with cardiovascular, gastrointestinal, and psychiatric diseases, all of which may affect morbidity and mortality among these patients. OBJECTIVE: To review available data regarding comorbidities associated with rosacea, discuss their pathogenesis, and highlight the evaluation of affected patients...
October 26, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29106028/association-of-high-anti-cyclic-citrullinated-peptide-seropositivity-and%C3%A2-lean-mass-index-with-low-bone-mineral-density-in-rheumatoid-arthritis
#12
Katherine D Wysham, Dolores M Shoback, John B Imboden, Patricia P Katz
OBJECTIVE: Osteoporotic fractures are associated with high morbidity and mortality. Persons with rheumatoid arthritis (RA) have twice the risk of osteoporosis-related fracture than age-matched controls, the causes for which remain unknown. We investigated contributions of RA characteristics, medication use, and body composition to low bone mineral density (BMD) in patients with RA. METHODS: Data were from the Arthritis, Body Composition, and Disability Study (n=138; 82 women, 56 men)...
November 5, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29101015/dna-damage-metabolism-and-aging-in-pro-inflammatory-t-cells-rheumatoid-arthritis-as-a-model-system
#13
REVIEW
Yinyin Li, Jörg J Goronzy, Cornelia M Weyand
The aging process is the major driver of morbidity and mortality, steeply increasing the risk to succumb to cancer, cardiovascular disease, infection and neurodegeneration. Inflammation is a common denominator in age-related pathologies, identifying the immune system as a gatekeeper in aging overall. Among immune cells, T cells are long-lived and exposed to intense replication pressure, making them sensitive to aging-related abnormalities. In successful T cell aging, numbers of naïve cells, repertoire diversity and activation thresholds are preserved as long as possible; in maladaptive T cell aging, protective T cell functions decline and pro-inflammatory effector cells are enriched...
November 8, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29097373/predictors-of-revision-prosthetic-joint-infection-and-mortality-following-total-hip-or-total-knee-arthroplasty-in-patients-with-rheumatoid-arthritis-a-nationwide-cohort-study-using-danish-healthcare-registers
#14
Rene Lindholm Cordtz, Kristian Zobbe, Pil Højgaard, Lars Erik Kristensen, Søren Overgaard, Anders Odgaard, Hanne Lindegaard, Lene Dreyer
OBJECTIVES: To investigate predictors of 10-year risk of revision and 1-year risk of prosthetic joint infection (PJI) and death following total hip/total knee arthroplasty (THA/TKA) in (1) patients with rheumatoid arthritis (RA) compared with patients with osteoarthritis (OA); and (2) patients with RA treated with biological disease-modifying antirheumatic drugs (bDMARD) within 90 days preceding surgery compared with non-treated. METHODS: Register-based cohort study using the Danish National Patient Register, the DANBIO rheumatology register (RA-specific confounders and treatment episodes) and the Danish Hip and Knee Arthroplasty Registers...
November 2, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29094181/cardiovascular-disease-in-patients-with-autoinflammatory-syndromes
#15
REVIEW
Rainer Hintenberger, Agnes Falkinger, Kathrin Danninger, Herwig Pieringer
Autoinflammatory syndromes (AIS) are characterized by recurring events of inflammation, leading to a variety of organ manifestations and fever attacks. A subgroup of AIS is commonly referred to as hereditary periodic fever syndromes (HPFS). There is substantial evidence that autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are strongly associated with cardiovascular morbidity and mortality. The link between AIS and cardiovascular disease is not that clear, even if the concept of continuous inflammation as a risk factor for cardiovascular disease is widely accepted...
November 1, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29092064/perspectives-on-polycystic-ovary-syndrome-is-polycystic-ovary-syndrome-research-underfunded
#16
Soumia Brakta, Daria Lizneva, Kateryna Mykhalchenko, Adonis Imam, Walidah Walker, Michael P Diamond, Ricardo Azziz
Context: The Polycystic Ovary Syndrome (PCOS) is a common endocrine-metabolic abnormality with a worldwide prevalence of 4%-21%, depending on diagnostic criteria. The National Institutes of Health (NIH) is the largest single funding agency in the world, invests nearly $30.0 billion annually in biomedical research. Evidence Acquisition: Utilizing the NIH RePorter system we searched for all grants awarded by the NIH for PCOS and three other disorders with comparable degrees of morbidity, and similar or lower mortality and prevalences (i...
September 19, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29081616/biological-response-modifiers-in-rheumatoid-arthritis-systematic-review-and-meta-analysis-of-safety
#17
Nitishkumar D Tank, Bharti N Karelia, Bhavisha N Vegada
OBJECTIVE: To analyze available evidence on the safety of different biological response modifiers which are used for a treatment of rheumatoid arthritis (RA). MATERIALS AND METHODS: We searched systematically for randomized controlled clinical trials on treatment of RA with different biological response modifiers, followed by a systematic review with meta-analysis. Trials were searched from MEDLINE and Cochrane Library databases. The following safety parameters reported in the selected trials were analyzed: number of patients suffering any adverse event (AE), withdrawal due to AEs, serious AE (SAEs), infections, serious infections, infusion reactions, injection site reactions, malignancies, and overall mortality...
July 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29081614/an-overview-of-the-extraarticular-involvement-in-rheumatoid-arthritis-and-its-management
#18
REVIEW
Subham Das, Prasanta Padhan
Rheumatoid arthritis (RA) is an autoimmune systemic disease characterized by long-standing inflammation and significant joint destruction. Despite significant research and success toward the treatment modalities, complete remission still remains a challenge. Even then a number of early and late extraarticular manifestations (EAMs) of the disease further complicate the disease progression. Various EAM encountered in RA can involve more than one organ or system in the body and their clinical features also show lot of variations, mostly involving cutaneous, cardiovascular, and pulmonary systems...
July 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29078844/risk-of-ischemic-heart-disease-in-patients-with-sj%C3%A3-gren-s-syndrome
#19
Faraz Khan Luni, Sonia Ali Malik, Abdur Rahman Khan, Haris Riaz, Hemindermeet Singh, Douglas Federman, Yusuf Kanjwal, Osama Dasa, Sadik Khuder, Ameer Kabour
BACKGROUND: Ischemic heart disease (IHD) has emerged as a major cause of morbidity and mortality in patients with autoimmune conditions such as systemic lupus erythematosus and rheumatoid arthritis, but the risk of IHD in Sjögren's syndrome (SjS) is unknown. To fill this knowledge gap, we estimated the prevalence and risk of IHD with SjS compared to controls from the general population using the Healthcare Cost and Utilization Project National Inpatient Sample 2011 database. MATERIALS AND METHODS: The Healthcare Cost and Utilization Project administrative longitudinal database contains encounter-level information on inpatient stays, emergency department visits and ambulatory surgery in all U...
October 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29063462/the-role-of-microalbuminuria-as-a-predictor-of-subclinical-cardiovascular-events-in-rheumatoid-arthritis-patients-and-its-relation-to-disease-activity
#20
D W Nada, S El Morsy, M H Abu-Zaid, M A Aboelhawa, Mohammad A Zakaria, E A El Sheikh, R A Gaber
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects many body tissues and leads to major morbidity and mortality. Renal disease in RA is clinically important because it restricts the management of primary disease and increases mortality. The objectives of this study are to (1) investigate the difference between RA patients with and without microalbuminuria (MAU) and (2) find out the relation between MAU and disease activity as well as subclinical cardiovascular effects. Ninety RA patients were divided into two groups according to the presence of MAU, in addition to 30 healthy volunteers...
October 23, 2017: Clinical Rheumatology
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