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https://www.readbyqxmd.com/read/29929518/obliterative-bronchiolitis-associated-with-rheumatoid-arthritis-analysis-of-a-single-center-case-series
#1
Erica Lin, Andrew H Limper, Teng Moua
BACKGROUND: Rheumatoid arthritis (RA) is a systemic autoimmune condition characterized by erosive inflammation of the joints. One rare pulmonary manifestation is obliterative bronchiolitis (OB), a small airways disease characterized by the destruction of bronchiolar epithelium and airflow obstruction. METHODS: We retrospectively reviewed the clinical data of patients with rheumatoid arthritis-associated obliterative bronchiolitis (RA-OB) from 01/01/2000 to 12/31/2015...
June 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29929117/psychiatric-comorbidity-increases-mortality-in-immune-mediated-inflammatory-diseases
#2
Ruth Ann Marrie, Randy Walld, James M Bolton, Jitender Sareen, Scott B Patten, Alexander Singer, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein
OBJECTIVE: We determined the association between any common mental disorder (CMD: depression, anxiety disorder, bipolar disorder) and mortality and suicide in three immune-mediated inflammatory diseases (IMID), inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA), versus age-, sex- and geographically-matched controls. METHODS: Using administrative data, we identified 28,384 IMID cases (IBD: 8695; MS: 5496; RA: 14,503) and 141,672 matched controls...
June 7, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29925278/sirukumab-for-the-treatment-of-rheumatoid-arthritis-update-on-sirukumab-2018
#3
Francesca Bartoli, Sangmee Bae, Laura Cometi, Marco Matucci Cerinic, Daniel E Furst
Interleukin-6 (IL-6) is well-known for its pro-inflammatory properties, has been proven to target a wide range of cells in the joint and has been implicated in extra-articular and articular manifestations in rheumatoid arthritis (RA). Tocilizumab (TCZ) is now widely used in patients with active RA and a number of additional agents that target the IL-6 pathways are under development, including sirukumab (SRK). Areas covered: SRK is a IgG1κ human anti-IL-6 monoclonal antibody which binds to IL-6 and prevents IL-6 mediated downstream effects...
June 21, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29922080/factors-correlated-with-the-improvement-of-endothelial-dysfunction-during-abatacept-therapy-in-patients-with-rheumatoid-arthritis
#4
Maurizio Benucci, Francesca Bandinelli, Arianna Damiani, Francesca Li Gobbi, Maria Infantino, Valentina Grossi, Mariangela Manfredi
Background: Rheumatoid arthritis patients are exposed to a high risk of cardiovascular morbidity and mortality even in the early phases of the disease. Methods: We evaluated carotid common carotid intimal media thickness (ccIMT) intimal thickness and brachial flow-mediated dilation (FMD) of 45 rheumatoid arthritis patients without known cardiovascular risk factors or heart disease on a stable dose of prednisone 5.2±1.2 mg/day and Methotrexate 11.5±2.1 mg at baseline (T0) and after 12 months (T1) of treatment with Abatacept 125 mg/week...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29905812/defective-cholesterol-metabolism-in-haematopoietic-stem-cells-promotes-monocyte-driven-atherosclerosis-in-rheumatoid-arthritis
#5
Dragana Dragoljevic, Michael J Kraakman, Prabhakara R Nagareddy, Devi Ngo, Waled Shihata, Helene L Kammoun, Alexandra Whillas, Man Kit Sam Lee, Annas Al-Sharea, Gerard Pernes, Michelle C Flynn, Graeme I Lancaster, Mark A Febbraio, Jaye Chin-Dusting, Beatriz Y Hanaoka, Ian P Wicks, Andrew J Murphy
Aim: Rheumatoid arthritis (RA) is associated with an approximately two-fold elevated risk of cardiovascular (CV)-related mortality. Patients with RA present with systemic inflammation including raised circulating myeloid cells, but fail to display traditional CV risk-factors, particularly dyslipidaemia. We aimed to explore if increased circulating myeloid cells is associated with impaired atherosclerotic lesion regression or altered progression in RA. Methods and results: Using flow cytometry, we noted prominent monocytosis, neutrophilia, and thrombocytosis in two mouse models of RA...
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29895751/bimodal-function-of-anti-tnf-treatment-shall-we-be-concerned-about-anti-tnf-treatment-in-patients-with-rheumatoid-arthritis-and-heart-failure
#6
REVIEW
Przemyslaw J Kotyla
Treatment with anti-TNF-α (tumor necrosis factor), one of the pivotal cytokines, was introduced to clinical practice at the end of last century and revolutionized the treatment of rheumatoid arthritis (RA) as well as many other inflammatory conditions. Such a treatment may however bring many safety issues regarding infections, tuberculosis, as well as cardiovascular diseases, including heart failure. Given the central role of proinflammatory cytokines in RA, atherosclerosis, and congestive heart failure (CHF), such a treatment might result in better control of the RA process on the one side and improvement of heart function on the other...
June 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29885537/impact-of-obesity-on-autoimmune-arthritis-and-its-cardiovascular-complications
#7
REVIEW
Katrien Van Raemdonck, Sadiq Umar, Zoltán Szekanecz, Ryan K Zomorrodi, Shiva Shahrara
Obesity can instigate and sustain a systemic low-grade inflammatory environment that can amplify autoimmune disorders and their associated comorbidities. Metabolic changes and inflammatory factors produced by the adipose tissue have been reported to aggravate autoimmunity and predispose the patient to cardiovascular disease (CVD) and metabolic comorbidities. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are autoimmune arthritic diseases, often linked with altered body mass index (BMI). Severe joint inflammation and bone destruction have a debilitating impact on the patient's life; there is also a staggering risk of cardiovascular morbidity and mortality...
June 6, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29879317/clinical-effectiveness-of-influenza-vaccination-in-patients-with-rheumatoid-arthritis
#8
Chun-Ming Chen, Hsuan-Ju Chen, Wei-Shan Chen, Che-Chen Lin, Chih-Cheng Hsu, Yueh-Han Hsu
OBJECTIVE: To determine the clinical effectiveness of influenza vaccination in patients with rheumatoid arthritis (RA). METHODS: The present study was conducted by using the Taiwan National Health Insurance Research Database. In this retrospective nationwide study, we included 3748 RA patients who received influenza vaccinations in 2008, 2009 and 2010, and 3748 matched RA patients who did not receive influenza vaccinations. We followed the patients from 4 weeks after influenza vaccination to the end of the influenza season in each year...
June 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29851818/difficulty-in-tracheal-extubation-followed-by-tracheal-collapse-after-balloon-dilatation-for-tracheal-stenosis-therapy-a-case-report
#9
Nana Li, Linjia Zhu, Jie Sun, Yinbing Pan, Mei Gao
RATIONALE: Tracheobronchomalacia (TBM) refers to the weakening trachea or the trachea loss of structural integrity of airway cartilaginous structures. It causes tracheal stenosis, resulting in significantly high rates of mortality. Bronchoplasty by high-pressure balloon dilation under general anesthesia is a simple but effective and safe method to treat tracheobronchial stenosis. However, recurrent postoperative dyspnea after extubation due to tracheal collapse is still a challenge for anesthetists...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29850453/transcriptome-analysis-of-porcine-pbmcs-reveals-the-immune-cascade-response-and-gene-ontology-terms-related-to-cell-death-and-fibrosis-in-the-progression-of-liver-failure
#10
YiMin Zhang, Li Shao, Ning Zhou, JianZhou Li, Yu Chen, Juan Lu, Jie Wang, ErMei Chen, ZhongYang Xie, LanJuan Li
Background: The key gene sets involved in the progression of acute liver failure (ALF), which has a high mortality rate, remain unclear. This study aims to gain a deeper understanding of the transcriptional response of peripheral blood mononuclear cells (PBMCs) following ALF. Methods: ALF was induced by D-galactosamine (D-gal) in a porcine model. PBMCs were separated at time zero (baseline group), 36 h (failure group), and 60 h (dying group) after D-gal injection...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29846814/cardiovascular-safety-of-biologics-and-jak-inhibitors-in-patients-with-rheumatoid-arthritis
#11
REVIEW
Eun Ha Kang, Katherine P Liao, Seoyoung C Kim
PURPOSE OF REVIEW: Increased cardiovascular (CV) risk and associated mortality in rheumatoid arthritis (RA) are not fully explained by traditional CV risk factors. This review discusses the epidemiology and mechanisms of increased CV risk in RA and treatment effects on CV risk focusing on biologic disease-modifying anti-rheumatic drugs (DMARDs) and JAK inhibitors. RECENT FINDINGS: Intermediary metabolic changes by inflammatory cytokines are observed in body composition, lipid profile, and insulin sensitivity of RA patients, leading to accelerated atherosclerosis and increased CV risk...
May 30, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29806092/the-lung-in-rheumatoid-arthritis-focus-on-interstitial-lung-disease
#12
REVIEW
Paolo Spagnolo, Joyce C Lee, Nicola Sverzellati, Giulio Rossi, Vincent Cottin
Interstitial lung disease (ILD) is an increasingly recognized complication of rheumatoid arthritis (RA) and is associated with significant morbidity and mortality. In addition, approximately one-third of patients have subclinical disease with varying degrees of functional impairment. While risk factors for RA-ILD are well established (e.g., older age, male gender, ever smoking history and seropositivity to rheumatoid factor and anti-cyclic citrullinated peptide antibodies) little is known about optimal disease assessment, treatment and monitoring, particularly in patients with progressive disease...
May 27, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29796636/rheumatoid-arthritis-and-excess-mortality-down-but-not-out-a-primary-care-cohort-study-using-data-from-clinical-practice-research-datalink
#13
Abhishek Abhishek, Georgina Nakafero, Chang-Fu Kuo, Christian Mallen, Weiya Zhang, Matthew J Grainge, Michael Doherty
Objectives: To examine temporal trends in all-cause and cause-specific mortality in RA. Methods: Data from the Clinical Practice Research Datalink were used. Incident RA cases and four age-, sex- and general practice-matched controls were identified from at-risk cohorts for each calendar year and followed-up for up to 5 years. Mortality rates and 95% CIs were computed. Cox proportional hazard ratios (HRs) were calculated to estimate associations and adjusted for covariates...
June 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29775082/profile-of-renal-aa-amyloidosis-in-older-and-younger-individuals-a-single-centre-experience
#14
Siyar Erdogmus, Zeynep Kendi Celebi, Serkan Akturk, Gizem Kumru, Neval Duman, Kenan Ates, Sehsuvar Erturk, Gokhan Nergizoglu, Sim Kutlay, Sule Sengul, Kenan Keven
OBJECTIVE: In epidemiological studies of amyloid A (AA) amyloidosis from Turkey, the most frequently cause was familial Mediterranean fever (FMF) and it occurs generally in young age population. However, there are no sufficient data regarding aetiology, clinical presentation and prognosis of renal AA amyloidosis in advanced age patients. In this study, we aimed to investigate demographic, clinical presentation, aetiology and outcomes of adults aged 60 years or older patients with biopsy-proven renal AA amyloidosis...
May 18, 2018: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/29759122/early-diagnosis-and-treatment-of-rheumatoid-arthritis
#15
REVIEW
Emily A Littlejohn, Seetha U Monrad
Rheumatoid arthritis is the most common inflammatory arthritis, and a significant cause of morbidity and mortality. Primary care providers should be able to distinguish the clinical presentation of rheumatoid arthritis from osteoarthritis, because the treatment and outcomes differ greatly between these 2 common forms of arthritis. This article provides a current overview of our understanding of rheumatoid arthritis, with an emphasis on early diagnosis and approaches to treatment.
June 2018: Primary Care
https://www.readbyqxmd.com/read/29748892/updated-pharmacological-management-of-rheumatoid-arthritis-for-women-before-during-and-after-pregnancy-reflecting-recent-guidelines
#16
Kieran E Murray, Louise Moore, Celine O'Brien, Anne Clohessy, Caroline Brophy, Patricia Minnock, Oliver FitzGerald, Eamonn S Molloy, Anne-Barbara Mongey, Shane Higgins, Mary F Higgins, Fionnuala M Mc Auliffe, Douglas J Veale
BACKGROUND: Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease which can cause significant disability, morbidity, mortality, and impaired fertility. It commonly affects women of childbearing age. Managing rheumatoid arthritis (RA) in the perinatal period poses challenges. There is concern about the teratogenic effects of many traditional disease-modifying anti-rheumatic drugs (DMARDs) and an ever-growing list of new therapeutic options with limited data in pregnancy and breastfeeding...
May 10, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29741136/mortality-and-its-predictors-in-patients-with-rheumatoid-arthritis-a-danish-population-based-inception-cohort-study
#17
J K Pedersen, R Holst, J Primdahl, A J Svendsen, K Hørslev-Petersen
OBJECTIVES: To investigate mortality and its predictors in a retrospectively defined population-based rheumatoid arthritis (RA) inception cohort Method: We included patients ascertained with incident RA from a region in the southern part of Denmark from 1995 to 2002. All patients fulfilled the 1987 American College of Rheumatology criteria for RA. The patients were followed from RA classification until death, emigration, or end of follow-up on 31 December 2013. We used personal record linkage with national public registers to obtain information on education, employment, cohabitation, comorbidity, and vital status...
May 9, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29731716/protective-effect-of-casperome-%C3%A2-an-orally-bioavailable-frankincense-extract-on-lipopolysaccharide-induced-systemic-inflammation-in-mice
#18
Konstantin Loeser, Semjon Seemann, Stefanie König, Isabell Lenhardt, Mona Abdel-Tawab, Andreas Koeberle, Oliver Werz, Amelie Lupp
Introduction: Despite recent advances in critical care, sepsis remains a crucial cause of morbidity and mortality in intensive care units. Therefore, the identification of new therapeutic strategies is of great importance. Since ancient times, frankincense is used in traditional medicine for the treatment of chronic inflammatory disorders such as rheumatoid arthritis. Thus, the present study intends to evaluate if Casperome® (Casp), an orally bioavailable soy lecithin-based formulation of standardized frankincense extract, is able to ameliorate systemic effects and organ damages induced by severe systemic inflammation using a murine model of sepsis, i...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29722740/rheumatoid-meningitis-a-case-review
#19
Angela M Parsons, Leslie A Zuniga, Joseph M Hoxworth, Mark Lyons, Fawad Aslam, Brent P Goodman
INTRODUCTION: Rheumatoid meningitis (RM) is a rare complication of rheumatoid arthritis (RA) and has a high mortality rate. It can present as a first diagnosis of RA, in long-standing disease, or in active or well-controlled disease. Neurological manifestations vary widely. CASE REPORT: A patient with a 30-year history of RA, well controlled with methotrexate therapy, presented with new-onset seizures. Magnetic resonance imaging showed leptomeningeal and pachymeningeal enhancement...
May 2018: Neurologist
https://www.readbyqxmd.com/read/29717163/in-patient-outcomes-of-hematopoietic-stem-cell-transplantation-in-patients-with-immune-mediated-inflammatory-diseases-a-nationwide-study
#20
Kathan Mehta, Palashkumar Jaiswal, Farren Briggs, William A Faubion, James H Tabibian, Fabio Cominelli, Maneesh Dave
The impact of underlying immune-mediated inflammatory diseases (IMID) in patients undergoing hematopoietic stem cell transplant (HSCT) is unclear. Hematopoietic cell transplantation co-morbidity index (HCT-CI) is gaining acceptance as a reliable clinical method to score pre-transplant co-morbidities. Higher HCT-CI from a co-morbid IMID implies higher NRM. However, HCT-CI integrates many IMIDs with different pathogenesis and treatment together which may lead to spurious results. We performed a cross-sectional study using Nationwide Inpatient Sample dataset from 1998 to 2011 to compare the outcomes of HSCT in patients with different co-morbid IMIDs with patients without any co-morbid IMIDs...
May 1, 2018: Scientific Reports
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