Thu A Doan, Tadg S Forward, Johnathon B Schafer, Erin D Lucas, Ira Fleming, Aspen Uecker-Martin, Edgardo Ayala, Jenna J Guthmiller, Jay R Hesselberth, Thomas E Morrison, Beth A Jirón Tamburini
Antigens from viruses or immunizations can persist or are archived in lymph node stromal cells such as lymphatic endothelial cells (LEC) and fibroblastic reticular cells (FRC). Here, we find that, during the time frame of antigen archiving, LEC apoptosis caused by a second, but unrelated, innate immune stimulus such as vaccina viral infection or CpG DNA administration resulted in cross-presentation of archived antigens and boosted memory CD8 + T cells specific to the archived antigen. In contrast to "bystander" activation associated with unrelated infections, the memory CD8 + T cells specific to the archived antigen from the immunization were significantly higher than memory CD8 + T cells of a different antigen specificity...
March 21, 2024: NPJ Vaccines