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https://www.readbyqxmd.com/read/28737373/construction-of-a-multi-cage-based-mof-with-a-unique-network-for-e%C3%AF-cient-co2-capture
#1
Mei-Hui Yu, Ping Zhang, Rui Feng, Zhao-Quan Yao, Yi-Chen Yu, Tong-Liang Hu, Xian-He Bu
As a kind of MOFs, cage-based MOFs usually carry large voids and small windows, which are advantageous to the storage of small molecules that remain kinetically trapped inside the cages (confinement effect). By adjusting the size of windows via reticular synthesis, the cage-based MOFs can selectively capture and separate the suitable size molecules. Here, considering angle-directed and face-directed strategies, a novel multi-cage-based MOF NUM-3 with a new (3,4,5)-connected topology was successfully constructed in the mixed-ligands assembly...
July 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28736332/5-hydroxytryptamine-2a-receptors-of-the-dorsal-raphe-nucleus-mediate-panic-like-behaviours-and-fear-induced-antinociception-elicited-by-neuronal-activation-in-the-central-nucleus-of-the-inferior-colliculus
#2
Raimundo da Silva Soares, Luiz Luciano Falconi-Sobrinho, Tayllon Dos Anjos-Garcia, Norberto Cysne Coimbra
It has been established that chemical stimulation of the inferior colliculus (IC) of laboratory animals evokes fear-related defensive responses, which are considered panic attack-like behaviours. In addition, there is evidence that defensive reactions provoked by chemical stimulation of midbrain tectum neurons may induce an antinociceptive response. Morphologically, the IC receives projections from other mesencephalic structures, such as the dorsal raphe nucleus (DRN), a region rich in serotonergic neurons that play a critical role in the control of defensive behaviours...
July 20, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28736303/the-good-and-the-bad-collagens-of-fibrosis-their-role-in-signaling-and-organ-function
#3
M A Karsdal, S H Nielsen, D J Leeming, L L Langholm, M J Nielsen, T Manon-Jensen, A Siebuhr, N S Gudmann, S Rønnow, J M Sand, S J Daniels, J H Mortensen, D Schuppan
Usually the dense extracellular structure in fibrotic tissues is described as extracellular matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already exemplified by the variant morphological characteristics of fibrosis due to viral versus cholestatic, autoimmune or toxic liver injury, with reticular, chicken wire and bridging fibrosis. Importantly, the overall composition of the ECM, especially the relative amounts of the many types of collagens, which represent the most abundant ECM molecules and which centrally modulate cellular functions and physiological processes, changes dramatically during fibrosis progression...
July 20, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28733485/il-17-promotes-differentiation-of-splenic-lsk-lymphoid-progenitors-into-b-cells-following-plasmodium-yoelii-infection
#4
Debopam Ghosh, Susie L Brown, Jason S Stumhofer
Lineage(-)Sca-1(+)c-Kit(-) (LSK(-)) cells are a lymphoid progenitor population that expands in the spleen and preferentially differentiates into mature B cells in response to Plasmodium yoelii infection in mice. Furthermore, LSK(-) derived B cells can subsequently contribute to the ongoing immune response through the generation of parasite-specific Ab-secreting cells, as well as germinal center and memory B cells. However, the factors that promote their differentiation into B cells in the spleen postinfection are not defined...
July 21, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28729371/geographic-atrophy-phenotype-identification-by-cluster-analysis
#5
Jordi Monés, Marc Biarnés
BACKGROUND/AIMS: To identify ocular phenotypes in patients with geographic atrophy secondary to age-related macular degeneration (GA) using a data-driven cluster analysis. METHODS: This was a retrospective analysis of data from a prospective, natural history study of patients with GA who were followed for ≥6 months. Cluster analysis was used to identify subgroups within the population based on the presence of several phenotypic features: soft drusen, reticular pseudodrusen (RPD), primary foveal atrophy, increased fundus autofluorescence (FAF), greyish FAF appearance and subfoveal choroidal thickness (SFCT)...
July 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729115/arousal-and-drug-abuse
#6
REVIEW
Francisco J Urbano, Verónica Bisagno, Edgar Garcia-Rill
The reticular activating system (RAS) is not an amorphous region but distinct nuclei with specific membrane properties that dictate their firing during waking and sleep. The locus coeruleus and raphe nucleus fire during waking and slow wave sleep, with the pedunculopontine nucleus (PPN) firing during both waking and REM sleep, the states manifesting arousal-related EEG activity. Two important discoveries in the PPN in the last 10 years are, 1) that some PPN cells are electrically coupled, and 2) every PPN cell manifests high threshold calcium channels that allow them to oscillate at beta/gamma band frequencies...
July 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28725546/pulmonary-involvement-in-adult-still-s-disease-case-report-and-brief-review-of-literature
#7
Aldo Guerrieri, Giulia Angeletti, Massimiliano Mazzolini, Ilaria Bassi, Stefano Nava
BACKGROUND: Adult onset Still disease (AOSD) is a rare condition characterized by elevated fever along with arthritic symptoms, elevated polymorphonuclear neutrophil count, evanescent rash, and hyperferritinemia. Diagnosis can be made only after have ruled out more frequent conditions, and Yamagouchi or Fautrel criteria should be applied. Parenchimal lung involvement (PLI) is present in less than 5% of AOSD cases and ranges from aspecific reticular interstitial opacities to life threatening conditions, such as acute respiratory distress syndrome (ARDS)...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28725185/reticular-formation-and-pain-the-past-and-the-future
#8
REVIEW
Isabel Martins, Isaura Tavares
The involvement of the reticular formation (RF) in the transmission and modulation of nociceptive information has been extensively studied. The brainstem RF contains several areas which are targeted by spinal cord afferents conveying nociceptive input. The arrival of nociceptive input to the RF may trigger alert reactions which generate a protective/defense reaction to pain. RF neurons located at the medulla oblongata and targeted by ascending nociceptive information are also involved in the control of vital functions that can be affected by pain, namely cardiovascular control...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28724360/injury-of-ascending-reticular-activating-system-associated-with-delayed-post-hypoxic-leukoencephalopathy-a-case-report
#9
Sung Ho Jang, Hyeok Gyu Kwon
BACKGROUND: Delayed post-hypoxic leukoencephalopathy (DPHL) is a demyelinating syndrome characterized by neurological relapse after an initial recovery from hypoxic brain injury. We describe a patient with impaired consciousness following DPHL, concurrent with injury of the ascending reticular activating system (ARAS) shown using diffusion tensor tractography (DTT). CASE PRESENTATION: A 50-year-old male patient was in a drowsy mental state after exposure to carbon monoxide (CO) for about ten hours...
July 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28722174/astrocytes-follow-ganglion-cell-axons-to-establish-an-angiogenic-template-during-retinal-development
#10
Matthew L O'Sullivan, Vanessa M Puñal, Patrick C Kerstein, Joseph A Brzezinski, Tom Glaser, Kevin M Wright, Jeremy N Kay
Immature astrocytes and blood vessels enter the developing mammalian retina at the optic nerve head and migrate peripherally to colonize the entire retinal nerve fiber layer (RNFL). Retinal vascularization is arrested in retinopathy of prematurity (ROP), a major cause of bilateral blindness in children. Despite their importance in normal development and ROP, the factors that control vascularization of the retina remain poorly understood. Because astrocytes form a reticular network that appears to provide a substrate for migrating endothelial cells, they have long been proposed to guide angiogenesis...
July 19, 2017: Glia
https://www.readbyqxmd.com/read/28718368/remodeling-of-extracellular-matrix-of-the-lamina-propria-in-the-uninvolved-human-rectal-mucosa-10-and-20%C3%A2-cm-away-from-the-malignant-tumor
#11
Sanja Z Despotović, Novica M Milićević, Dragoslav P Milošević, Nebojša Despotović, Predrag Erceg, Petar Svorcan, Udo Schumacher, Sebastian Ullrich, Gordana Mihajlović, Dragan Kalem, Srđan Marković, Ivana M Lalić, Aleksandar J Krmpot, Mihailo D Rabasović, Dejan V Pantelić, Svetlana Z Jovanić, Thomas Rösch, Živana Milićević
In recent years, it has been demonstrated that malignancy arises and advances through the molecular interplay between tumor cells and non-malignant elements of the tumor stroma, that is, fibroblasts and extracellular matrix. However, in contrast to the mounting evidence about the role of tumor stroma in the genesis and progression of the malignant disease, there are very few data regarding the uninvolved stromal tissue in the remote surrounding of the tumor. Using the objective morphometric approach in patients with adenocarcinoma, we demonstrate the remodeling of extracellular matrix of the lamina propria in the uninvolved rectal mucosa 10 and 20 cm away from the neoplasm...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28716782/the-reticular-activating-system-in-the-wake-of-temporal-lobe-epilepsy-dazed-and-confused
#12
EDITORIAL
John D Rolston
No abstract text is available yet for this article.
July 17, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28716439/renal-cell-carcinoma-unclassified-with-medullary-phenotype-poorly-differentiated-adenocarcinomas-overlapping-with-renal-medullary-carcinoma
#13
Deepika Sirohi, Steven C Smith, Chisato Ohe, Piergiuseppe Colombo, Mukul Divatia, Ema Dragoescu, Priya Rao, Michelle S Hirsch, Ying-Bei Chen, Rohit Mehra, Mahul B Amin
Renal medullary carcinoma (RMC) is a highly aggressive renal cell carcinoma, arising in the collecting system, and requiring careful correlation with status of sickle cell trait. A panel of international experts has recently proposed provisional diagnostic terminology, renal cell carcinoma, unclassified, with medullary phenotype (RCCU-MP), based on encountering an extraordinarily rare tumor with RMC morphology and immunophenotype in an individual proven not to have a hemoglobinopathy. Herein, we extend this observation to a cohort of five such tumors, morphologically similar to RMC, lacking SMARCB1 expression by immunohistochemistry, but each without evidence of a hemoglobinopathy...
July 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28714107/the-braf-and-nras-mutation-prevalence-in-dermoscopic-subtypes-of-acquired-naevi-reveals-constitutive-mapk-pathway-activation
#14
J M Tan, L N Tom, K Jagirdar, D Lambie, H Schaider, R A Sturm, H P Soyer, M S Stark
BACKGROUND: Acquired naevi can have unique dermoscopic patterns that correspond to distinct microanatomical growth patterns. Previous studies on acquired naevi stratified according to dermoscopic pattern, focused on the frequency of somatic BRAF mutations, whereas NRAS mutations remained to be elucidated. OBJECTIVES: To investigate the BRAF and NRAS mutation prevalence and activation of the MAPK pathway in distinct dermoscopic subtypes of acquired naevi. METHODS: Common mutations present in BRAF and NRAS were assessed in 40 globular, reticular, and peripheral rim of globules (PG) subtypes of acquired naevi from 27 participants (19 male, 8 female; mean age 46...
July 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28705285/childhood-onset-keratosis-lichenoides-chronica-accompanied-by-severe-hair-loss
#15
Sibel Dogan, Efsun Kılınç, Gül Erkin Özaygen, Nilgün Atakan, Özay Gököz, Sibel Ersoy Evans
A 37-year-old woman attended the dermatology outpatient clinic because of recent hair loss from the eyebrows and axillae. Her past medical history revealed mild generalized erythema and hyperpigmented papules and plaques since childhood. On dermatologic examination, there were flat-topped, purple to brown hyperkeratotic lichenoid papules and linear plaques on the elbows, trunk, and buttocks, some of which coalesced into hyperpigmented reticular plaques on the axillae, neck, and groin. Mild erythema was noted...
2017: Skinmed
https://www.readbyqxmd.com/read/28701742/tissue-engineered-trachea-from-a-3d-printed-scaffold-enhances-whole-segment-tracheal-repair
#16
Manchen Gao, Hengyi Zhang, Wei Dong, Jie Bai, Botao Gao, Dekai Xia, Bei Feng, Maolin Chen, Xiaomin He, Meng Yin, Zhiwei Xu, Nevin Witman, Wei Fu, Jinghao Zheng
Long segmental repair of trachea stenosis is an intractable condition in the clinic. The reconstruction of an artificial substitute by tissue engineering is a promising approach to solve this unmet clinical need. 3D printing technology provides an infinite possibility for engineering a trachea. Here, we 3D printed a biodegradable reticular polycaprolactone (PCL) scaffold with similar morphology to the whole segment of rabbits' native trachea. The 3D-printed scaffold was suspended in culture with chondrocytes for 2 (Group I) or 4 (Group II) weeks, respectively...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700005/fluorescent-test-accurately-predicts-leak-of-ischemic-colon-anastomosis-in-rats
#17
Laura Moschetti, Tiago Leal Ghezzi, Belisa Gomes Müller, Adriano Basso Dias, Oly Campos Corleta
Purpose: To investigate if fluorescein fluorescent test can predict dehiscence in a model of ischemic colonic anastomosis in rats. Methods: This experimental controlled trial randomly assigned 55 rats to four groups. Anastomoses were performed in non-ischemic colon segments (control group) and in ischemic colon segments measuring 1, 2 or 3 cm long (groups 1, 2 and 3, respectively). Fluorescein was injected and the tissues were examined under ultraviolet light. Seven days later, a second-look surgery was performed to check for the presence or absence of anastomosis dehiscence...
June 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28698519/crystallization-of-covalent-organic-frameworks-for-gas-storage-applications
#18
REVIEW
Lijuan Zhu, Yue-Biao Zhang
Covalent organic frameworks (COFs) have emerged as a new class of crystalline porous materials prepared by integrating organic molecular building blocks into predetermined network structures entirely through strong covalent bonds. The consequently encountered "crystallization problem" has been conquered by dynamic covalent chemistry in syntheses and reticular chemistry in materials design. In this contribution, we have reviewed the progress in the crystallization of COF materials and their hydrogen, methane and carbon dioxide gas storage properties for clean energy applications...
July 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28695452/chronic-hepatitis-b-correlation-of-abnormal-features-on-t2-weighted-imaging-and-dynamic-contrast-enhanced-imaging-with-hepatic-histopathology
#19
Jian Shu, Jian Nong Zhao, Fu Gang Han, Guang Cai Tang, Xin Chen
OBJECTIVES: To investigate the correlations between abnormal features on liver magnetic resonance (MR) T2-weighted imaging (T2WI) and dynamic contrast-enhanced (DCE) imaging and the pathological findings in chronic hepatitis B. MATERIALS AND METHODS: Sixty-seven patients with chronic hepatitis B and 18 normal controls who were undergone an abdominal MR imaging were analyzed retrospectively. Patchy hyperintensities, linear and reticular hyperintensities in liver and periportal edema on T2WI and abnormal intrahepatic enhancement signals on DCE imaging were noted...
July 10, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28691457/human-%C3%AE-2-defensin-in-oral-lichen-planus-expresses-the-degree-of-inflammation
#20
L Azzi, P Moretto, R Vinci, F Croveri, A Boggio, J Silvestre-Rangil, L Tettamanti, A Tagliabue, A Passi
Syndrome (BMS). Seventeen OLP patients, with a positive histopathologic diagnosis of the disease, were recruited into this study in order to measure the relative quantity of HBD-2 in their saliva and crevicular fluid. The values were compared with those collected from a group of 9 patients affected by the Burning Mouth Syndrome (BMS) and with a control group (CTRL) of 9 patients. There was no statistically significant difference between the groups (p=0.523; p=0.897). However, patients affected by OLP showed a dycotomic distribution of values: while 10 of them showed similar values to those found out in the other two groups, 7 patients expressed high levels of HBD-2 and 3500 pg/ml was the threshold to distinguish the subgroups...
April 2017: Journal of Biological Regulators and Homeostatic Agents
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