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https://www.readbyqxmd.com/read/29329908/anatomical-evidence-for-lateral-hypothalamic-innervation-of-the-pontine-a7-catecholamine-cell-group-in-rat
#1
Janean E Holden, Monica A Wagner, Brady L Reeves
Substantial behavioral evidence exists to support the idea that the lateral hypothalamus (LH) makes axonal connection with spinally-projecting noradrenergic neurons of the A7 catecholamine cell group in the pons. Through this putative projection, the LH modulates nociception via α1- and α2-adrenoceptors in the dorsal horn. We used double-label immunocytochemistry to demonstrate that axons from the LH labeled with the anterograde tracer biotinylated dextran amine (BDA) appose tyrosine hydroxylase-immunoreactive (TH-ir) neuron profiles in the A7 area...
January 9, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29328527/pruritic-papulovesicular-dermatosis-with-reticular-hyperpigmentation
#2
Victor Olsavszky, Cyrill Géraud
No abstract text is available yet for this article.
January 12, 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29327340/shank3-deficient-thalamocortical-neurons-show-hcn-channelopathy-and-alterations-in-intrinsic-electrical-properties
#3
Mengye Zhu, VinayKumar Idikuda, Jianbing Wang, Fusheng Wei, Virang Kumar, Nikhil Shah, Christopher B Waite, Qinglian Liu, Lei Zhou
Shank3 is a scaffolding protein that is highly enriched in excitatory synapses. Mutations in Shank3 gene have been linked to neuropsychiatric disorders especially the Autism Spectrum Disorders (ASD). Shank3 deficiency is known to cause impairments in synaptic transmission, but its effects on basic neuronal electrical properties that are more localized to the soma and proximal dendrites remain unclear. Here we confirmed that in heterologous expression systems two different Shank3 isoforms, Shank3A and Shank3C, significant increase the surface expression of the hyperpolarization-activated, cyclic-nucleotide-gated (HCN) channel...
January 12, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29326500/a-comparative-evaluation-between-cheiloscopic-patterns-and-terminal-planes-in-primary-dentition
#4
R Vignesh, C Vishnu Rekha, Sankar Annamalai, Parisa Norouzi, Ditto Sharmin
Objective: To assess the correlation between different cheiloscopic patterns with the terminal planes in deciduous dentition. Materials and Methods: Three hundred children who are 3-6 years old with complete primary dentition were recruited, and the pattern of molar terminal plane was recorded in the pro forma. Lip prints of these children were recorded with lipstick-cellophane method, and the middle 10 mm of lower lip was analyzed for the lip print pattern as suggested by Sivapathasundharam et al...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29323065/emerging-role-of-preputial-vascular-pattern-and-postoperative-microvessel-density-in-cases-of-proximal-hypospadias-a-pilot-study
#5
Vishrut Narang, Amita Sen, Minakshi Bhardwaj
INTRODUCTION: Understanding of anatomical vascular patterns and anatomy of prepuce is critical for a good outcome in hypospadias surgery. A well-vascularized neourethral and preputial flaps used for repair are exceptionally important for a successful outcome, especially in cases of proximal hypospadias undergoing one-stage procedures. OBJECTIVE: To evaluate the vascular anatomy of prepuce in cases of proximal hypospadias and to evaluate microvessel density (MVD) by immunohistochemistry and its correlation with postoperative complications...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29315552/projections-of-three-subcortical-visual-centres-to-marmoset-lateral-geniculate-nucleus
#6
Natalie Zeater, Péter Buzás, Bogdan Dreher, Ulrike Grünert, Paul R Martin
The dorsal lateral geniculate nucleus receives projections from visuotopically organised subcortical nuclei, in addition to inputs from the retina, visual cortices, and the thalamic reticular nucleus. Here, we study subcortical projections to the geniculate from the superior colliculus (SC) and parabigeminal nucleus (PBG) in the midbrain, and the nucleus of the optic tract (NOT) in the pretectum of marmosets. Marmosets are New World diurnal foveate monkeys, and are an increasingly popular model for studying the primate visual system...
January 9, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29304218/selective-vulnerability-of-brainstem-nuclei-in-distinct-tauopathies-a-postmortem-study
#7
Rana A Eser, Alexander J Ehrenberg, Cathrine Petersen, Sara Dunlop, Maria B Mejia, Claudia K Suemoto, Christine M Walsh, Hima Rajana, Jun Oh, Panos Theofilas, William W Seeley, Bruce L Miller, Thomas C Neylan, Helmut Heinsen, Lea T Grinberg
The brainstem nuclei of the reticular formation (RF) are critical for regulating homeostasis, behavior, and cognition. RF degenerates in tauopathies including Alzheimer disease (AD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Although the burden of phopho-tau inclusion is high across these diseases, suggesting a similar vulnerability pattern, a distinct RF-associated clinical phenotype in these diseases indicates the opposite. To compare patterns of RF selective vulnerability to tauopathies, we analyzed 5 RF nuclei in tissue from 14 AD, 14 CBD, 10 PSP, and 3 control cases...
January 2, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29303151/swept-source-and-optical-coherence-tomography-angiography-in-patients-with-x-linked-retinoschisis
#8
N Padrón-Pérez, J Català-Mora, J Díaz, L Arias, J Prat, J M Caminal
PurposeTo explore the structural features of juvenile X-linked retinoschisis (XLRS) using swept-source-optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCT-A).DesignRetrospective, observational cross-sectional study.Patients and methodsNine patients (18 eyes) diagnosed with juvenile XLRS were included. SS-OCT and OCT-A were used to evaluate the characteristics of the inner/outer retina and the choroid.ResultsSS-OCT showed that the inner nuclear layer (INL) was the most commonly affected area (16/18 eyes; 89%)...
January 5, 2018: Eye
https://www.readbyqxmd.com/read/29302615/homeostatic-changes-in-gaba-and-acetylcholine-muscarinic-receptors-on-gabaergic-neurons-in-the-mesencephalic-reticular-formation-following-sleep-deprivation
#9
Hanieh Toossi, Esther Del Cid-Pellitero, Barbara E Jones
We have examined whether GABAergic neurons in the mesencephalic reticular formation (RFMes), which are believed to inhibit the neurons in the pons that generate paradoxical sleep (PS or REMS), are submitted to homeostatic regulation under conditions of sleep deprivation (SD) by enforced waking during the day in mice. Using immunofluorescence, we investigated first, by staining for c-Fos, whether GABAergic RFMes neurons are active during SD and then, by staining for receptors, whether their activity is associated with homeostatic changes in GABAA or acetylcholine muscarinic type 2 (AChM2) receptors (Rs), which evoke inhibition...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29296091/xanthelasma-palpebrarum-a-brief-review
#10
REVIEW
Pragya A Nair, Rochit Singhal
Xanthelasma palpebrarum is the most common cutaneous xanthoma, characterized by yellowish plaques over eyelids - most commonly, over the inner canthus of the upper lid. It is triggered by hyperlipidemia, thyroid dysfunction, and diabetes mellitus. Xanthelasma results from perivascular infiltration of mono- and multinucleated foam cells within lipid-laden cytoplasmic vacuoles in the superficial reticular dermis. Different modalities of treatment, such as simple surgical excision, cryotherapy, chemical peeling with trichloroacetic acid, radiofrequency, and laser, are used in the treatment of xanthelasma palpebrarum...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29290554/a-non-canonical-reticular-limbic-central-auditory-pathway-via-medial-septum-contributes-to-fear-conditioning
#11
Guang-Wei Zhang, Wen-Jian Sun, Brian Zingg, Li Shen, Jufang He, Ying Xiong, Huizhong W Tao, Li I Zhang
In the mammalian brain, auditory information is known to be processed along a central ascending pathway leading to auditory cortex (AC). Whether there exist any major pathways beyond this canonical auditory neuraxis remains unclear. In awake mice, we found that auditory responses in entorhinal cortex (EC) cannot be explained by a previously proposed relay from AC based on response properties. By combining anatomical tracing and optogenetic/pharmacological manipulations, we discovered that EC received auditory input primarily from the medial septum (MS), rather than AC...
December 21, 2017: Neuron
https://www.readbyqxmd.com/read/29287748/drug-associated-hyperpigmentation-of-the-oral-mucosa-report-of-four-cases
#12
REVIEW
Konstantinos I Tosios, Eleni-Marina Kalogirou, Alexandra Sklavounou
OBJECTIVE: The aim of this study was to describe 4 patients with oral mucosa hyperpigmentation associated with 4 drug classes and to review the relevant literature. STUDY DESIGN: Two patients under imatinib and hydroxychloroquine treatment exhibited diffuse palatal hyperpigmentation and 2 patients treated with minocycline and golimumab showed multifocal pigmented macules. In all cases, biopsy was performed. RESULTS: Microscopically, in all cases, there was no increase in the number of melanocytes in the epithelium, and pigment granules were present in the lamina propria...
November 3, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29284263/reticular-electronic-tuning-of-porphyrin-active-sites-in-covalent-organic-frameworks-for-electrocatalytic-carbon-dioxide-reduction
#13
Christian S Diercks, Song Lin, Nikolay Kornienko, Eugene A Kapustin, Eva M Nichols, Chenhui Zhu, Yingbo Zhao, Christopher J Chang, Omar M Yaghi
The electronic character of porphyrin active sites for electrocatalytic reduction of CO2 to CO in a two-dimensional covalent organic framework (COF) was tuned by modification of the reticular structure. Efficient charge transport along the COF backbone promotes electronic connectivity between remote functional groups and the active sites and enables the modulation of the catalytic properties of the system. A series of oriented thin films of these COFs was found to reduce CO2 to CO at low overpotential (550 mV) with high selectivity (faradaic efficiency of 87%) and at high current densities (65 mA/mg) - a performance well beyond related molecular catalysts in regard to selectivity and efficiency...
December 29, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29282774/adult-moyamoya-disease-associated-with-abundant-phosphorylated-tau-accumulation-in-the-brainstem-report-of-a-case-with-autopsy-findings
#14
Koichi Okamoto, Isao Naito, Toshio Fukuda, Keiji Suzuki, Masamitsu Takatama
We report the case of a 72-year-old Japanese woman with moyamoya disease (MMD). She experienced her first intracerebral hemorrhage (ICH) at the age of 32 years, and had nine ICHs and/or intraventricular hemorrhages during the following 40 years. Cerebral angiograms and vascular pathologies at autopsy confirmed that the patient suffered from MMD. Macroscopically, there were brown-colored changes in the subarachnoid space, mainly at the base of the brain and around the cerebellar hemispheres. Microscopically, hemosiderin deposits were observed mainly in the old hemorrhagic lesions and on the surface of the brainstem and cerebellum...
December 27, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29277012/photoelectrochemical-biosensor-for-hen1-rna-methyltransferase-detection-using-peroxidase-mimics-ptcu-nfs-and-poly-u-polymerase-mediated-rna-extension
#15
Haiyan Wang, Libang Zhu, Junling Duan, Minghui Wang, Huanshun Yin, Po Wang, Shiyun Ai
2'-O-methyl group on the 3' terminal nucleotide in plant microRNAs, as one kind of RNA methylations, is caused by HEN1 RNA methyltransferase (HENMT1), which is thought to be crucial for ribosome biogenesis and function. Herein, a simple and label-free PEC biosensing method was proposed for assay of HENMT1 activity and inhibitor screening based on peroxidase mimic PtCu nanoframes (PtCu NFs) catalytic signal amplification. In this work, MoS2@Graphene quantum dots/Phosphorus-doped rodlike carbon nitride (MoS2@GQDs/P-RCN) heterojunction was used as photoactive materials...
December 21, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29276975/non-tip-auditory-nerve-responses-that-are-suppressed-by-low-frequency-bias-tones-originate-from-reticular-lamina-motion
#16
Hui Nam, John J Guinan
Recent cochlear mechanical measurements show that active processes increase the motion response of the reticular lamina (RL) at frequencies more than an octave below the local characteristic frequency (CF) for CFs above 5 kHz. A possible correlate is that in high-CF (>5 kHz) auditory-nerve (AN) fibers, responses to frequencies 1-3 octaves below CF ("tail" frequencies) can be inhibited by medial olivocochlear (MOC) efferents. These results indicate that active processes enhance the sensitivity of tail-frequency RL and AN responses...
December 14, 2017: Hearing Research
https://www.readbyqxmd.com/read/29274977/technical-note-changes-in-rumen-mucosa-thickness-measured-by-transabdominal-ultrasound-as-a-noninvasive-method-to-diagnose-subacute-rumen-acidosis-in-dairy-cows
#17
V Neubauer, E Humer, I Kröger, A Meißl, N Reisinger, Q Zebeli
Feeding high-grain diets leads to the release and accumulation of short-chain fatty acids in the rumen. The subsequent prolonged decline in ruminal pH can lead to subacute ruminal acidosis (SARA). Accumulation of short-chain fatty acids can cause proliferation of rumen papillae to increase absorption surface, subsequently leading to a thickening of the rumen mucosa. The aim of this study was to evaluate the appropriateness of continuous measurements of the rumen mucosa thickness (RMT) as a diagnostic tool for SARA in dairy cows compared with continuous measurements of ruminal pH...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29273603/tenuous-inhibitory-gabaergic-signaling-in-the-reticular-thalamus
#18
Peter M Klein, Adam Lu, Megan E Harper, Hannah M McKown, Jessica Morgan, Mark P Beenhakker
Maintenance of a low intracellular Cl- concentration ([Cl-]i) is critical for enabling inhibitory neuronal responses to GABAA receptor-mediated signaling. Cl- transporters, including KCC2, and extracellular impermeant anions ([A]o) of the extracellular matrix are both proposed to be important regulators of [Cl-]i Neurons of the reticular thalamic (RT) nucleus express reduced levels of KCC2, indicating that GABAergic signaling may produce excitation in RT neurons. However, by performing perforated patch recordings and calcium imaging experiments in rats (male and female), we find that [Cl-]i remains relatively low in RT neurons...
December 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29259834/a-patient-with-non-hodgkin-lymphoma-and-nonspecific-interstitial-pneumonia-during-ibrutinib-therapy
#19
Sven Jungmann, Wolf-Dieter Ludwig, Nicolas Schönfeld, Torsten-Gerriet Blum, Claudia Großwendt, Christian Boch, Beate Rehbock, Sergej Griff, Alexander Schmittel, Torsten T Bauer
We present a 74-year-old male with nonspecific interstitial pneumonia (NSIP) during treatment with ibrutinib for mantle cell lymphoma. Previously, the patient had received six cycles of bendamustine and rituximab and six cycles of R-CHOP, followed by rituximab maintenance therapy. Respiratory tract complications of ibrutinib other than infectious pneumonia have not been mentioned in larger trials, but individual case reports hinted to a possible association with the development of pneumonitis. In our patient, the onset of alveolitis that progressed towards NSIP together with the onset of ibrutinib treatment suggests causality...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29259049/scleroderma-fibroblasts-suppress-angiogenesis-via-tgf-%C3%AE-caveolin-1-dependent-secretion-of-pigment-epithelium-derived-factor
#20
Vasiliki Liakouli, Jacobo Elies Comez, Yasser Mohamed El-Sherbiny, Margherita Scarcia, Gary Grant, Giuseppina Abignano, Emma C Derrett-Smith, Filomena Esteves, Paola Cipriani, Paul Emery, Christopher P Denton, Roberto Giacomelli, Georgia Mavria, Francesco Del Galdo
OBJECTIVES: Systemic sclerosis (SSc) is characterised by tissue fibrosis and vasculopathy with defective angiogenesis. Transforming growth factor beta (TGF-β) plays a major role in tissue fibrosis, including downregulation of caveolin-1 (Cav-1); however, its role in defective angiogenesis is less clear. Pigment epithelium-derived factor (PEDF), a major antiangiogenic factor, is abundantly secreted by SSc fibroblasts. Here, we investigated the effect of TGF-β and Cav-1 on PEDF expression and the role of PEDF in the ability of SSc fibroblasts to modulate angiogenesis...
December 19, 2017: Annals of the Rheumatic Diseases
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