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Smoking pancreatitis

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https://www.readbyqxmd.com/read/29884547/the-incretin-hormone-gip-is-upregulated-in-patients-with-atherosclerosis-and-stabilizes-plaques-in-apoe-mice-by-blocking-monocyte-macrophage-activation
#1
Florian Kahles, Ana Liberman, Constantin Halim, Matthias Rau, Julia Möllmann, Robert Werner Mertens, Marcia Rückbeil, Irmgard Diepolder, Benedikt Walla, Sebastian Diebold, Mathias Burgmaier, Corinna Lebherz, Nikolaus Marx, Michael Lehrke
OBJECTIVE: The incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by the gut after food intake leading to pancreatic insulin secretion and glucose lowering. Beyond its role in glucose control, GLP-1 was found in mice and men to beneficially modulate the process of atherosclerosis, which has been linked to improved cardiovascular outcome of patients with diabetes at high cardiovascular risk treated with GLP-1 receptor agonists...
May 23, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29883461/the-different-course-of-alcoholic-and-idiopathic-chronic-pancreatitis-a-long-term-study-of-2-037-patients
#2
Lu Hao, Li-Sheng Wang, Yu Liu, Teng Wang, Hong-Lei Guo, Jun Pan, Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Lei Xin, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Xiang-Peng Zeng, Wen-Bin Zou, Hui Chen, Ting Xie, Bai-Rong Li, Zhuan Liao, Zhi-Jie Cong, Zheng-Lei Xu, Zhao-Shen Li, Liang-Hao Hu
BACKGROUND: Chronic pancreatitis (CP) is a chronic inflammatory disease of the pancreas. This study aimed to compare the natural course of alcoholic chronic pancreatitis (ACP) and idiopathic chronic pancreatitis (ICP). METHODS: CP patients admitted to our center from January 2000 to December 2013 were enrolled. Characteristics were compared between ACP and ICP patients. Cumulative rates of diabetes mellitus (DM), steatorrhea, pancreatic stone, pancreatic pseudocyst, biliary stricture, and pancreatic cancer after the onset and the diagnosis of CP were calculated, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29881614/pancreatic-function-following-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-a-controlled-cohort-study-with-long-term-follow-up
#3
Bonna Leerhøy, Daniel M Shabanzadeh, Andreas Nordholm-Carstensen, Srdan Novovic, Mark B Hansen, Lars N Jørgensen
Background: Acute pancreatitis is one of the most common causes of gastrointestinal-related hospitalization and the incidence is increasing. Endo- and exocrine pancreatic function can be compromised after acute pancreatitis. Objective: The purpose of this study was to explore the long-term consequences of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) on pancreatic function. Methods: A follow-up study was carried out with prospective assessment of endo- and exocrine pancreatic function among cases with previous PEP and matched controls from a Danish cohort consisting of 772 patients undergoing first-time ERCP...
May 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29870540/cigarette-toxin-4-methylnitrosamino-1-3-pyridyl-1-butanone-nnk-induces-experimental-pancreatitis-through-%C3%AE-7-nicotinic-acetylcholine-receptors-nachrs-in-mice
#4
A A Alahmari, B Sreekumar, V Patel, M Ashat, M Alexandre, A K Uduman, E O Akinbiyi, A Ceplenski, C A Shugrue, T R Kolodecik, N Tashkandi, S W Messenger, G E Groblewski, F S Gorelick, E C Thrower
Clinical studies have shown that cigarette smoking is a dose-dependent and independent risk factor for acute pancreatitis. Cigarette smoke contains nicotine which can be converted to the potent receptor ligand and toxin, NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone]. Previously, we have shown that NNK induces premature activation of pancreatic zymogens in rats, an initiating event in pancreatitis, and this activation is prevented by pharmacologic inhibition of nicotinic acetylcholine receptors (nAChR)...
2018: PloS One
https://www.readbyqxmd.com/read/29869090/perioperative-net-fluid-balance-predicts-pancreatic-fistula-after-pancreaticoduodenectomy
#5
Leah K Winer, Vikrom K Dhar, Koffi Wima, Tiffany C Lee, Mackenzie C Morris, Shimul A Shah, Syed A Ahmad, Sameer H Patel
BACKGROUND: Our goal was to evaluate the relationship between perioperative fluid administration and the development of clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreaticoduodenectomy (PD). METHODS: Retrospectively, we analyzed fluid balance over the first 72 h in 104 consecutive patients who underwent PD between 2013 and 2017. Patients were categorized into tertiles (low, medium, and high) by net fluid balance. RESULTS: POPF was identified in 17...
June 4, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29864419/cigarette-smoke-induces-stem-cell-features-of-pancreatic-cancer-cells-via-paf1
#6
Rama Krishna Nimmakayala, Parthasarathy Seshacharyulu, Imayavaramban Lakshmanan, Satyanarayana Rachagani, Seema Chugh, Saswati Karmakar, Sanchita Rauth, Raghupathy Vengoji, Pranita Atri, Geoffrey A Talmon, Subodh M Lele, Lynette M Smith, Ishwor Thapa, Dhundy Bastola, Michel M Ouellette, Surinder K Batra, Moorthy P Ponnusamy
BACKGROUND & AIMS: Cigarette smoking is a major risk factor for pancreatic cancer. Aggressive pancreatic tumors contain cancer cells with stem cell features. We investigated whether cigarette smoke induces stem cell features in pancreatic cancer cells. METHODS: KrasG12D ; Pdx1-Cre (KC) mice were exposed to cigarette smoke or clean air (controls) for up to 20 weeks; pancreata were collected and analyzed by histology, quantitative reverse transcription PCR, and confocal immunofluorescence microscopy...
June 1, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29863911/genetically-induced-vs-classical-animal-models-of-chronic-pancreatitis-a-critical-comparison
#7
Sarah Klauss, Stephan Schorn, Steffen Teller, Hendrik Steenfadt, Helmut Friess, Güralp O Ceyhan, Ihsan Ekin Demir
Chronic pancreatitis (CP) is an utmost complex disease that is pathogenetically linked to pancreas-intrinsic ( e.g., duct obstruction), environmental-toxic ( e.g., alcohol, smoking), and genetic factors. Studying such a complex disease naturally requires validated experimental models. In the past 2 decades, the various animal models of CP usually addressed either the pancreas-intrinsic ( e.g., the caerulein model), the environmental-toxic ( e.g., diet-induced models), or the genetic component of CP. As such, these models were far from mirroring CP in its full spectrum, and the correct choice of models was vital for valid scientific conclusions on CP...
June 4, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29804849/the-impact-of-unplanned-conversion-to-an-open-procedure-during-minimally-invasive-pancreatectomy
#8
Zachary E Stiles, Paxton V Dickson, Jeremiah L Deneve, Evan S Glazer, Lei Dong, Jim Y Wan, Stephen W Behrman
BACKGROUND: Minimally invasive pancreatic resection (MIPR) is being increasingly utilized. Outcomes for patients experiencing unplanned conversion to an open procedure during MIPR have been incompletely assessed. We sought to determine the short-term outcomes and factors associated with unplanned conversion during MIPR. METHODS: A retrospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program pancreatectomy-targeted data set was conducted...
July 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29800296/response-to-variation-of-the-age-at-onset-of-pancreatic-cancer-according-to-tobacco-smoking-and-family-history
#9
Esther Molina-Montes, Núria Malats
No abstract text is available yet for this article.
May 23, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29800142/variation-of-the-age-at-onset-of-pancreatic-cancer-according-to-tobacco-smoking-and-family-history
#10
Patrick Maisonneuve, Albert B Lowenfels
No abstract text is available yet for this article.
May 23, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29773760/a-review-of-methods-for-preventing-pancreatic-fistula-after-distal-pancreatectomy
#11
Katarzyna Mech, Łukasz Wysocki, Tomasz Guzel, Marcin Makiewicz, Paweł Nyckowski, Maciej Słodkowski
Pancreatic fistula is one of the most severe complications after pancreatic surgeries. The risk of pancreatic fistula after distal pancreatectomy is up to 60%. Effective methods to prevent pancreatic fistula are still sought. A unified definition of pancreatic fistula, which was introduced in 2005 by the International Study Group of Pancreatic Surgery (ISGPS), has allowed for an easier diagnosis and determination of fistula severity, as well as for a reliable inter-center comparison of data. Furthermore, a number of publications point out the risk factors of pancreatic fistula, which may be classified into patient-related risk factors, such as MBI, gender, smoking tobacco or pancreatic structure; and surgery-related risk factors, such as blood loss, prolonged surgery and non-underpinning of the major pancreatic duct...
April 30, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29662231/processed-meat-and-risk-of-selected-digestive-tract-and-laryngeal-cancers
#12
Valentina Rosato, Daisuke Kawakita, Eva Negri, Diego Serraino, Werner Garavello, Maurizio Montella, Adriano Decarli, Carlo La Vecchia, Monica Ferraroni
BACKGROUND/OBJECTIVES: To assess the association between processed meat and the risk of selected digestive tract and laryngeal cancers. SUBJECTS/METHODS: We conducted a series of case-control studies between 1985 and 2007 in Italy. The studies included a total of 1475 cases of cancer of the oral cavity and pharynx, 1077 of the larynx, 716 of the esophagus, 999 of the stomach, 684 of the liver, 159 of the biliary tract, 688 of the pancreas, and a total of 9720 controls...
April 16, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29660323/nationwide-trends-in-acute-and-chronic-pancreatitis-among-privately-insured-children-and-non-elderly-adults-in-the-united-states-2007-2014
#13
Zachary M Sellers, Donna MacIsaac, Helen Yu, Melody Dehghan, Ke-You Zhang, Rachel Bensen, Jessie J Wong, Cindy Kin, K T Park
BACKGROUND & AIMS: Epidemiologic analyses of acute and chronic pancreatitis (AP and CP) provide insight into causes and strategies for prevention, and affect allocation of resources to its study and treatment. We sought to determine current and accurate incidences of AP and CP, along with the prevalence of CP, in children and adults in the United States. METHODS: We collected data from the Truven MarketScan Research Databases of commercial inpatient and outpatient insurance claims in the United States from 2007 through 2014 (patients 0-64 years old)...
April 13, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29644986/evaluation-of-fatigue-in-patients-with-pancreatic-cancer-receiving-chemotherapy-treatment-a-cross-sectional-observational-study
#14
Mariacristina Di Marco, Ivan Rubbi, Agnese Baldi, Rosaria Di Lorenzo, Daniela Magnani, Valeria Cremonini, Leopoldo Sarli, Giovanna Artioli, Paola Ferri
BACKGROUND AND AIM OF THE WORK: Cancer-related fatigue (CRF) is one of the most common symptoms experienced by cancer patients (CPs) and negatively affects quality of life. Although CRF is frequently experienced, it is often underreported, underdiagnosed and undertreated. The objectives of this study were to evaluate the level of fatigue in patients with pancreatic cancer undergoing chemotherapy and to analyse its correlation with patients' demographic and clinical variables. METHODS: A cross-sectional observational study was implemented in the Oncology Day Hospital of a Northern Italian hospital...
February 27, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29643268/proposed-cut-off-value-of-ca19-9-for-detecting-pancreatic-cancer-in-patients-with-diabetes-a-case-control-study
#15
Mariko Murakami, Yoshio Nagai, Ayumi Tenjin, Yasushi Tanaka
Pancreatic cancer is a highly lethal malignancy. CA19-9 is a well-known marker for diagnosis of pancreatic cancer, but the serum CA19-9 level is reported to be elevated in patients with poorly controlled diabetes. This study evaluated the sensitivity, specificity, and cut-off value of serum CA19-9 for detection of pancreatic cancer in patients with diabetes. A case-control study of 236 patients was performed. The case group was selected from diabetic patients with pancreatic cancer, while one control was selected for each case from among diabetic patients without pancreatic cancer during the same period...
April 11, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29629907/incidence-admission-rates-and-predictors-and-economic-burden-of-adult-emergency-visits-for-acute-pancreatitis-data-from-the-national-emergency-department-sample-2006-to-2012
#16
Sushil K Garg, Shashank Sarvepalli, James P Campbell, Itegbemie Obaitan, Dupinder Singh, Fateh Bazerbachi, Rajeshwar Singh, Madhusudhan R Sanaka
INTRODUCTION: Acute pancreatitis (AP) is the most common gastroenterology-related reason for hospital admission, and a major source of morbidity and mortality in the United States. This study examines the National Emergency Database Sample, a large national database, to analyze trends in emergency department (ED) utilization and costs, risk factors for hospital admission, and associated hospital costs and length of stay (LOS) in patients presenting with AP. METHODS: The National Emergency Database Sample (2006 to 2012) was evaluated for trends in ED visits, ED charges, hospitalization rates, hospital charges, and hospital LOS in patients with primary diagnosis of AP (further subcategorized by age and etiology)...
April 6, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29626481/nicotine-induces-aberrant-hypermethylation-of-tumor-suppressor-genes-in-pancreatic-epithelial-ductal-cells
#17
Tong Jin, Jianyu Hao, Daiming Fan
Tobacco smoking is an independent risk factor for the initiation of pancreatic cancer (PC). Hypermethylation of tumor suppressor genes has been demonstrated to be associated with smoking. This study aimed to find the relationship between nicotine exposure and hypermethylation of tumor suppressor genes in normal pancreatic epithelial cells. Human pancreatic epithelial cells ware cultured exposing to nicotine and the methylation status of tumor suppressor genes were detected. Proenkephalin (PENK) was chosen as the target gene and methylation level of PENK promoter region was measured...
May 23, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29602793/effects-of-smoking-versus-nonsmoking-on-postprandial-glucose-metabolism-in-heavy-smokers-compared-with-nonsmokers
#18
Magnus F Grøndahl, Jonatan I Bagger, Asger Lund, Annesofie Faurschou, Jens F Rehfeld, Jens J Holst, Tina Vilsbøll, Filip K Knop
OBJECTIVE: Epidemiological studies suggest that smoking increases the risk of type 2 diabetes. We hypothesized that smoking-derived nicotine and ensuing activation of nicotinic cholinergic receptors in the gastrointestinal tract and the autonomic nervous system would have a detrimental effect on postprandial glucose metabolism and, thus, potentially constitute a link between smoking and the development of type 2 diabetes. RESEARCH DESIGN AND METHODS: We subjected 11 male heavy smokers to two identical 4-h liquid mixed-meal tests: one with concomitant cigarette smoking (immediately before and after meal intake) and one without smoking...
June 2018: Diabetes Care
https://www.readbyqxmd.com/read/29587290/chemoprevention-and-treatment-of-pancreatic-cancer-update-and-review-of-the-literature
#19
Julia Benzel, Volker Fendrich
BACKGROUND: Pancreatic ductal adenocarcinoma is one of the most lethal types of cancer with a 5-year survival rate of around 7%. Due to the relatively poor prognosis, the potential need of an effective chemoprevention is highly needed. SUMMARY: Different risk factors like smoking or hereditary tumour syndromes should be known for early detection of pancreatic intraepithelial neoplasia. Chemopreventive dietary agents include curcumin, capsaicin and flavonoid, whereas potential chemopreventive drugs compromise aspirin, metformin or statins...
2018: Digestion
https://www.readbyqxmd.com/read/29558826/diabetes-mellitus-secondary-to-pancreatic-diseases-type-3c-the-effect-of-smoking-on-the-exocrine-endocrine-interactions-of-the-pancreas
#20
Mariola Śliwińska-Mossoń, Stanisław Milnerowicz, Halina Milnerowicz
The present study was conducted to ascertain how cigarette smoke affects the exocrine-endocrine interactions of the human pancreas with diabetes mellitus secondary to pancreatic diseases (type 3c). Blood has been collected from smoking and non-smoking healthy individuals as well as from patients with diagnosed chronic pancreatitis and diabetes type 3c. The concentrations of interleukin-6, endothelin-1 and insulin in the plasma were determined by enzyme-linked immunosorbent assay (ELISA) tests. The activities of amylase and lipase in the serum, as well as the lipid profile, creatinine, uric acid and urea concentrations, were measured using colorimetric methods...
May 2018: Diabetes & Vascular Disease Research
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