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Smoking pancreatitis

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https://www.readbyqxmd.com/read/29209605/the-effect-of-cigarette-smoking-during-pregnancy-on-endocrine-pancreatic-function-and-fetal-growth-a-pilot-study
#1
Fatima Lockhart, Anthony Liu, Bernard Linton Champion, Michael John Peek, Ralph Kay Heinrich Nanan, Alison Sally Poulton
Introduction: Cigarette smoking in pregnancy is a common cause of fetal growth restriction. We aimed to investigate endocrine pancreatic function of mother-infant dyads in relation to cigarette smoking, as a possible mechanism for the poor fetal growth. Methods: Prospective study of smoking mothers (10 cigarettes or more per day, self-reported to the midwife) and non-smoker control mothers during their first pregnancy. Insulin, glucose, C-peptide, HbA1C, fructosamine, prolactin, serotonin, and cortisol were measured in maternal blood at 24-26 weeks and in umbilical cord blood at birth...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29195672/tobacco-and-alcohol-as-risk-factors-for-pancreatic-cancer
#2
REVIEW
Murray Korc, Christie Y Jeon, Mouad Edderkaoui, Stephen J Pandol, Maxim S Petrov
Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. It also provided a state-of-the-art review of animal studies on the effect of tobacco smoke and alcohol on genetically engineered mouse models of pancreatic precursor lesions, as well as the role of immune microenvironment in pancreatic carcinogenesis activated by tobacco and alcohol...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29195671/alcohol-smoking-and-benign-hepato-biliary-disease
#3
REVIEW
Daniel Mønsted Shabanzadeh, Srdan Novovic
Gallstone disease and pancreatitis are the most frequent benign hepato-biliary causes of hospital admissions. Gallstone disease is prevalent, but symptomatic disease develops only in about one out of five carriers. Alcohol intake seems to protect gallstone formation in cohort studies possibly through effects on bile cholesterol metabolism, the enterohepatic circulation, and gallbladder function. The impact of smoking on gallstone formation seems minor. Both alcohol intake and smoking do not alter the clinical course of gallstone disease carriers...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29151827/tumor-necrosis-factor-like-weak-inducer-of-apoptosis-regulates-quadriceps-muscle-atrophy-and-fiber-type-alteration-in-a-rat-model-of-chronic-obstructive-pulmonary-disease
#4
Jun-Juan Lu, Qing Wang, Li Hua Xie, Qiang Zhang, Sheng Hua Sun
Background: In chronic obstructive pulmonary disease (COPD), weakness and muscle mass loss of the quadriceps muscle has been demonstrated to predict survival and mortality rates of patients. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), as a member of the TNF superfamily, has recently been identified as a key regulator of skeletal muscle wasting and metabolic dysfunction. So our aim was to study the role of TWEAK during quadriceps muscle atrophy and fiber-type transformation in COPD model rats and its possible pathway...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/29149259/pancreatic-cancer-incidence-trends-evidence-from-the-surveillance-epidemiology-and-end-results-seer-population-based-data
#5
Vanessa L Gordon-Dseagu, Susan S Devesa, Michael Goggins, Rachael Stolzenberg-Solomon
Background: Annual pancreatic cancer incidence rates have been increasing. We examine pancreatic cancer incidence trends by demographics and histologic type. Methods: Data from the Surveillance, Epidemiology and End Results (SEER) registries were available to assess temporal trends and pancreatic cancer rates from 1974 to 2013. Results: Pancreatic cancer incidence rates declined between the 1970s and 1990s but increased from 1994 to 2013 among White males...
November 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29129073/stage-dependence-cell-origin-independence-and-prognostic-capacity-of-serum-glycan-fucosylation-%C3%AE-1-4-branching-%C3%AE-1-6-branching-and-%C3%AE-2-6-sialylation-in-cancer
#6
Shadi Ferdosi, Douglas S Rehder, Paul Maranian, Erik P Castle, Thai H Ho, Harvey I Pass, Daniel W Cramer, Karen S Anderson, Lei Fu, David E C Cole, Tao Le, Xifeng Wu, Chad R Borges
Glycans represent a promising but only marginally accessed source of cancer markers. We previously reported the development of a molecularly bottom-up approach to plasma and serum (P/S) glycomics based on glycan linkage analysis that captures features such as α2-6 sialylation, β1-6 branching, and core fucosylation as single analytical signals. Based on the behavior of P/S glycans established to date, we hypothesized that the alteration of P/S glycans observed in cancer would be independent of the tissue in which the tumor originated yet exhibit stage dependence that varied little between cancers classified on the basis of tumor origin...
November 21, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29114875/circulating-concentrations-of-vitamin-d-in-relation-to-pancreatic-cancer-risk-in-european-populations
#7
Fränzel J B van Duijnhoven, Mazda Jenab, Kristian Hveem, Peter D Siersema, Veronika Fedirko, Eric J Duell, Ellen Kampman, Anouk Halfweeg, Henk J van Kranen, Jody M W van den Ouweland, Elisabete Weiderpass, Neil Murphy, Arnulf Langhammer, Eivind Ness-Jensen, Anja Olsen, Anne Tjønneland, Kim Overvad, Claire Cadeau, Marina Kvaskoff, Marie-Christine Boutron-Ruault, Verena A Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Anastasia Kotanidou, Maria Kritikou, Domenico Palli, Claudia Agnoli, Rosario Tumino, Salvatore Panico, Giuseppe Matullo, Petra Peeters, Magritt Brustad, Karina Standahl Olsen, Cristina Lasheras, Mireia Obón-Santacana, María-José Sánchez, Miren Dorronsoro, Maria-Dolores Chirlaque, Aurelio Barricarte, Jonas Manjer, Martin Almquist, Frida Renström, Weimin Ye, Nick Wareham, Kay-Tee Khaw, Kathryn E Bradbury, Heinz Freisling, Dagfinn Aune, Teresa Norat, Elio Riboli, H Bas Bueno-de-Mesquita
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer. However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and pancreatic cancer incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts...
November 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29113292/nod-mice-susceptible-to-pancreatic-autoimmunity-demonstrate-delayed-growth-of-pancreatic-cancer
#8
James Dooley, Emanuela Pasciuto, Vasiliki Lagou, Yulia Lampi, Tom Dresselaers, Uwe Himmelreich, Adrian Liston
Pancreatic cancer is a high mortality form of cancer, with a median survival only six months. There are multiple associated risk factors associated, most importantly type 2 diabetes, obesity, pancreatitis and smoking. The relative rarity of the disease, however, has made it difficult to dissect causative risk factors, especially with related risk factors. A major unanswered question with important therapeutic implications is the effect of immunological responses on pancreatic cancer formation, with data from other cancers suggesting the potential for local immunological responses to either increase cancer development or increase cancer elimination...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104871/smoking-gender-and-overweight-are-important-influencing-factors-on-monocytic-hla-dr-before-and-after-major-cancer-surgery
#9
Gunnar Lachmann, Clarissa von Haefen, Johannes Kurth, Fatima Yuerek, Klaus-Dieter Wernecke, Claudia Spies
Background: Monocytic human leukocyte antigen D related (mHLA-DR) is essential for antigen-presentation. Downregulation of mHLA-DR emerged as a general biomarker of impaired immunity seen in patients with sepsis and pneumonia and after major surgery. Influencing factors of mHLA-DR such as age, overweight, diabetes, smoking, and gender remain unclear. Methods: We analyzed 20 patients after esophageal or pancreatic resection of a prospective, randomized, placebo-controlled, double-blind trial (placebo group)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29100845/smoking-and-drinking-synergize-in-pancreatitis-multiple-hits-on-a-multiple-targets
#10
EDITORIAL
Miklós Sahin-Tóth, Péter Hegyi
No abstract text is available yet for this article.
October 31, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29081601/resistin-as-a-prooxidant-factor-and-predictor-of-endothelium-damage-in-patients-with-mild-acute-pancreatitis-exposed-to-tobacco-smoke-xenobiotics
#11
Milena Ściskalska, Grzegorz Marek, Zygmunt Grzebieniak, Halina Milnerowicz
OBJECTIVES: The study was aimed to assess the influence of tobacco smoke exposure on the intensity of inflammation measured by IL-6, α1-antitripsin (AAT) and α1-acid glycoprotein (AGP) concentrations, and Cd level and oxidative stress intensity measured by advanced oxidation protein product (AOPP) concentration in the blood of healthy subjects and AP patients during hospitalization. Endothelin-1 (ET-1) and resistin concentrations, markers of endothelium injury, were determined. RESULTS: An increased IL-6 concentration in healthy smokers compared to nonsmokers and AP patients compared to controls was shown...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28991938/intraoral-lesion-%C3%A2-history-of-cirrhosis-and-smoking-%C3%A2-dx
#12
Ezinne I Ogbureke, Ruth E Conn, Dennis E Garcia, Cleverick D Johnson
A 56-year-old white man presented at our dental clinic for routine care. The intraoral examination revealed an asymptomatic red lesion with white vesicle-like areas on the right side of the soft palate. The extraoral examination was normal, and regional lymph nodes were nonpalpable. The patient's medical history included liver cirrhosis and pancreatitis. He also had a 30-year history of alcohol misuse (1-5 drinks per day) and a 30-pack-year smoking history. (The patient had stopped drinking at the time of presentation, and had quit smoking 2 years earlier...
October 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28988572/uniting-epidemiology-and-experimental-disease-models-for-alcohol-related-pancreatic-disease
#13
Veronica Wendy Setiawan, Kristine Monroe, Aurelia Lugea, Dhiraj Yadav, Stephen Pandol
Findings from epidemiologic studies and research with experimental animal models provide insights into alcohol-related disease pathogeneses. Epidemiologic data indicate that heavy drinking and smoking are associated with high rates of pancreatic disease. Less clear is the association between lower levels of drinking and pancreatitis. Intriguingly, a very low percentage of drinkers develop clinical pancreatitis. Experimental models demonstrate that alcohol administration alone does not initiate pancreatitis but does sensitize the pancreas to disease...
2017: Alcohol Research: Current Reviews
https://www.readbyqxmd.com/read/28982582/interplay-between-innate-immunity-and-iron-metabolism-after-acute-pancreatitis
#14
Shayal K Chand, Ruma G Singh, Sayali A Pendharkar, Sakina H Bharmal, Maxim S Petrov
Emerging evidence shows that chronic low-grade inflammation and changes in markers of innate immunity are implicated in a range of metabolic abnormalities following an episode of acute pancreatitis. Also, deranged iron metabolism has been linked to type 2 diabetes mellitus, gestational diabetes, and new-onset diabetes after pancreatitis - the conditions characterized by high haemoglobin glycation index (HGI). This study aimed to investigate the associations between markers of innate immunity and iron metabolism in individuals after acute pancreatitis...
October 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28974895/body-mass-index-does-not-affect-the-survival-of-pancreatic-cancer-patients
#15
Qing-Long Jiang, Cheng-Feng Wang, Yan-Tao Tian, Huang Huang, Shui-Sheng Zhang, Dong-Bing Zhao, Jie Ma, Wei Yuan, Yue-Min Sun, Xu Che, Jian-Wei Zhang, Yun-Mian Chu, Ya-Wei Zhang, Ying-Tai Chen
AIM: To evaluate the association of body mass index (BMI) with the overall survival of pancreatic ductal adenocarcinoma (PDAC) patients. METHODS: A retrospective analysis of PDAC patients diagnosed in the National Cancer Center of China between January 1999 and December 2014 was performed. These patients were categorized into four BMI groups (< 18.5, 18.5-22.9, 23-27.4 and ≥ 27.5 kg/m(2)). χ(2) tests for comparison of the proportions of categorical variables, and Student's t-test or Mann-Whitney test for continuous variables were employed...
September 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28969358/possible-role-of-diet-in-cancer-systematic-review-and-multiple-meta-analyses-of-dietary-patterns-lifestyle-factors-and-cancer-risk
#16
Giuseppe Grosso, Francesca Bella, Justyna Godos, Salvatore Sciacca, Daniele Del Rio, Sumantra Ray, Fabio Galvano, Edward L Giovannucci
Context: Evidence of an association between dietary patterns derived a posteriori and risk of cancer has not been reviewed comprehensively. Objective: The aim of this review was to investigate the relation between a posteriori-derived dietary patterns, grouped as healthy or unhealthy, and cancer risk. The relation between cancer risk and background characteristics associated with adherence to dietary patterns was also examined. Data Sources: PubMed and Embase electronic databases were searched...
June 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28968289/chymotrypsinogen-c-genetic-variants-including-c-180tt-are-strongly-associated-with-chronic-pancreatitis-in-pediatric-patients
#17
Alicja Monika Grabarczyk, Grzegorz Oracz, Katarzyna Wertheim-Tysarowska, Aleksandra Anna Kujko, Karolina Wejnarska, Elwira Kolodziejczyk, Jerzy Bal, Dorota Koziel, Artur Kowalik, Stanislaw Gluszek, Agnieszka Magdalena Rygiel
OBJECTIVES: Genetic studies in adults/adolescent patients with chronic pancreatitis (CP) identified chymotrypsinogen C (CTRC) genetic variants but their association with CP risk has been difficult to replicate. To evaluate the risk of CP associated with CTRC variants in CP pediatric patients-control study. METHODS: The distribution of CTRC variants in CP pediatric cohort (n = 136, median age at CP onset 8 years) with no history of alcohol/smoking abuse was compared with controls (n = 401, median age 45)...
December 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28961573/risk-factors-and-nomogram-for-common-bile-duct-stricture-in-chronic-pancreatitis-a-cohort-of-2153-patients
#18
Lu Hao, Ya-Wei Bi, Di Zhang, Xiang-Peng Zeng, Lei Xin, Jun Pan, Dan Wang, Jun-Tao Ji, Ting-Ting Du, Jin-Huan Lin, Bo Ye, Wen-Bin Zou, Hui Chen, Ting Xie, Bai-Rong Li, Zhao-Hong Zheng, Teng Wang, Hong-Lei Guo, Zhuan Liao, Zhao-Shen Li, Liang-Hao Hu
GOALS: To identify the risk factors and develop nomograms for common bile duct (CBD) stricture in chronic pancreatitis (CP) patients. BACKGROUND: CBD stricture is a common complication in CP and has a variable clinical presentation ranging from asymptomatic to overt jaundice and cholangitis. STUDY: Patients with CP admitted to Changhai Hospital (Shanghai, China) from January 2000 to December 2013 were enrolled. Cumulative rates of CBD stricture after onset and diagnosis of CP were calculated...
September 28, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28961214/cadmium-and-cadmium-zinc-ratios-and-tobacco-related-morbidities
#19
REVIEW
Patricia Richter, Obaid Faroon, R Steven Pappas
Metals are one of five major categories of carcinogenic or toxic constituents in tobacco and tobacco smoke. Cadmium is highly volatile and a higher percentage of the total tobacco cadmium content is efficiently transferred to mainstream tobacco smoke than many other toxic metals in tobacco. Inhaled cadmium bioaccumulates in the lungs and is distributed beyond the lungs to other tissues, with a total body biological half-life of one to two decades. Chronic cadmium exposure through tobacco use elevates blood and urine cadmium concentrations...
September 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28958690/relationship-between-circulating-levels-of-pancreatic-proteolytic-enzymes-and-pancreatic-hormones
#20
Sakina H Bharmal, Sayali A Pendharkar, Ruma G Singh, Mark O Goodarzi, Stephen J Pandol, Maxim S Petrov
BACKGROUND: While the close morphological relationship between the exocrine and endocrine pancreas is well established, their functional interaction remains poorly understood. The aim of this study was to investigate the associations between circulating levels of pancreatic proteolytic enzymes and insulin, as well as other pancreatic hormones. METHODS: Fasting venous blood samples were collected and analyzed for trypsin, chymotrypsin, insulin, glucagon, somatostatin, and pancreatic polypeptide...
September 20, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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