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Smoking pancreatitis

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https://www.readbyqxmd.com/read/27918953/cross-talk-between-innate-cytokines-and-the-pancreatic-polypeptide-family-in-acute-pancreatitis
#1
Sayali A Pendharkar, Ruma G Singh, Maxim S Petrov
BACKGROUND AND AIM: Low-grade inflammation persists in patients with acute pancreatitis (AP) after hospital discharge, and is linked to metabolic disorders. Neuropeptide Y (NPY) is well recognized as an important mediator of inflammation in these patients but the role of the other two structurally similar peptides, pancreatic polypeptide (PP) and peptide YY (PYY), in inflammation has been sparsely investigated. The aim was to investigate the association between PYY, PP, NPY and circulating levels of innate cytokines in patients after AP...
December 2, 2016: Cytokine
https://www.readbyqxmd.com/read/27914516/leukotriene-b4-induces-emt-and-vimentin-expression-in-panc-1-pancreatic-cancer-cells-involvement-of-blt2-via-erk2-activation
#2
You Ri Kim, Mi Kyung Park, Gyeong Jin Kang, Hyun Ji Kim, Eun Ji Kim, Hyun Jung Byun, Moo-Yeol Lee, Chang Hoon Lee
Leukotriene B4 (LTB4) is a leukocyte chemoattractant and plays a major role controlling inflammatory responses including pancreatitis. LTB4 is known to be correlated with cancer progression. LTB4 induces keratin phosphorylation and reorganization by activating extracellular regulated kinase (ERK) in PANC-1 pancreatic cancer cell lines. However, the role of LTB4 in epithelial mesenchymal transition (EMT) and vimentin expression in pancreatic cancer cells is unknown. We examined whether LTB4 induces EMT and vimentin expression by Western blot, si-RNA, and RT-PCR...
December 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27885308/pancreatic-cancer-a-survival-analysis-study-in-oklahoma
#3
Margaret Wahutu, Sara K Vesely, Janis Campbell, Anne Pate, Alicia L Salvatore, Amanda E Janitz
BACKGROUND: Pancreatic cancer is among the most deadly cancers. Risk factors associated with the disease include age, race, sex, smoking status, and diabetes status. METHOD: We conducted a prospective analysis of risk factors and length of survival among pancreatic cancer patients living in Oklahoma between 1997 and 2012 (n=6,291). Kaplan-Meier survival curves were created followed by the log-rank test to compare difference in the survival time. Cox proportional hazard regression models were used to examine the strength of association through the estimated hazard ratios...
July 2016: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/27875360/outcomes-after-conservative-endoscopic-and-surgical-treatment-of-groove-pancreatitis-a-systematic-review
#4
Liesbeth M Kager, Selma J Lekkerkerker, Marianna Arvanitakis, Myriam Delhaye, Paul Fockens, Marja A Boermeester, Jeanin E van Hooft, Marc G Besselink
BACKGROUND: Groove pancreatitis (GP) is a focal form of chronic pancreatitis affecting the paraduodenal groove area, for which consensus on diagnosis and management is lacking. GOALS: We performed a systematic review of the literature to determine patient characteristics and imaging features of GP and to evaluate clinical outcomes after treatment. RESULTS: Eight studies were included reporting on 335 GP patients with a median age of 47 years (range, 34 to 64 y), with 90% male, 87% smokers, and 87% alcohol consumption, and 47 months (range, 15 to 122 mo) of follow-up...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27846144/low-alcohol-and-cigarette-use-is-associated-to-the-risk-of-developing-chronic-pancreatitis
#5
Milena Di Leo, Gioacchino Leandro, Satish K Singh, Alberto Mariani, Margherita Bianco, Raffaella Alessia Zuppardo, Elisabetta Goni, Teresa Marzia Rogger, Francesco Di Mario, Mario Guslandi, Francesco De Cobelli, Alessandro Del Maschio, Pier Alberto Testoni, Giulia Martina Cavestro
OBJECTIVES: The aim of this study was to investigate the contribution of smoking and alcohol intake and pancreas divisum on the risk of developing chronic pancreatitis (CP). METHODS: Consecutive patients with CP who underwent secretin-enhanced magnetic resonance cholangiopancreatography were compared with consecutive patients without pancreatic disease who underwent secretin-enhanced magnetic resonance cholangiopancreatography for irritable bowel syndrome. RESULTS: We enrolled 145 consecutive CP patients and 103 irritable bowel syndrome patients from 2010 to 2014...
November 11, 2016: Pancreas
https://www.readbyqxmd.com/read/27846138/alcohol-consumption-and-cigarette-smoking-are-important-modifiers-of-the-association-between-acute-pancreatitis-and-the-prss1-prss2-locus-in-men
#6
Alexey V Polonikov, Tatyana A Samgina, Petr M Nazarenko, Olga Y Bushueva, Vladimir P Ivanov
OBJECTIVES: The present study was designed to investigate whether the susceptibility to acute pancreatitis (AP) attributable to polymorphism rs10273639 at the PRSS1-PRSS2 locus is dependent on alcohol consumption and cigarette smoking. METHODS: A total of 603 unrelated Russian individuals including 304 patients with physician-diagnosed AP and 299 sex- and age-matched healthy controls have been recruited for the study. A polymorphism rs10273639 (-408C>T) of PRSS1-PRSS2 was genotyped by TaqMan-based assay...
November 11, 2016: Pancreas
https://www.readbyqxmd.com/read/27836330/evaluation-of-rosemont-criteria-for-non-calcific-chronic-pancreatitis-nccp-based-on-histopathology-a-retrospective-study
#7
Guru Trikudanathan, Satish Munigala, Usman Barlass, Ahmad Malli, Yusheng Han, Miroslav Sekulic, Melena Bellin, Srinath Chinnakotla, Ty Dunn, Timothy Pruett, Gregory Beilman, Jose-Vega Peralta, Mustafa Arain, Stuart Amateau, Shawn Mallery, Martin L Freeman, Rajeev Attam
BACKGROUND: Rosemont classification for chronic pancreatitis has not been evaluated specifically in non-calcific chronic pancreatitis (NCCP) patients and to this date, it has not been correlated with the gold standard namely histopathology. OBJECTIVE: To assess the correlation of EUS Rosemont criteria for NCCP with histopathology from surgical specimens and evaluate the impact of age, sex, BMI, smoking and alcohol on Rosemont classification. METHODS: Adult patients undergoing TPIAT for NCCP between July 2009 and January 2013 were identified from our institutional database...
October 26, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27832994/possible-involvement-of-inos-and-tnf-%C3%AE-in-nutritional-intervention-against-nicotine-induced-pancreatic-islet-cell-damage
#8
Ankita Bhattacharjee, Shilpi Kumari Prasad, Swagata Pal, Bithin Maji, Arnab Banerjee, Debasmita Das, Ananya Bose, Nabanita Chatterjee, Sandip Mukherjee
Nicotine is the more abundant and most significant components of cigarette smoke. Epidemiological evidence strongly suggests an association between cigarette smoking and pancreatic injury. Although effects of smoking on endocrine pancreas are still controversial Here, we examined the impact and underlying mechanisms of action of folic acid and vitamin B12 on nicotine induced damage in pancreatic islets of rats. Male Wistar rats were treated with nicotine (3mg/kg body weight/day, intraperitonealy) with or without folic acid (36μg/kg body weight/day, orally) and vitamin B12 (0...
November 7, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27820614/nonfasting-mild-to-moderate-hypertriglyceridemia-and-risk-of-acute-pancreatitis
#9
Simon B Pedersen, Anne Langsted, Børge G Nordestgaard
Importance: Severe hypertriglyceridemia is associated with increased risk of acute pancreatitis. However, the threshold above which triglycerides are associated with acute pancreatitis is unclear. Objective: To test the hypothesis that nonfasting mild-to-moderate hypertriglyceridemia (177-885 mg/dL; 2-10 mmol/L) is also associated with acute pancreatitis. Design, Setting, and Participants: This prospective cohort study examines individuals from the Copenhagen General Population Study in 2003 to 2015 and the Copenhagen City Heart Study initiated in 1976 to 1978 with follow-up examinations in 1981 to1983, 1991 to 1994, and in 2001 to 2003...
December 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27817122/nonsteroidal-anti-inflammatory-drugs-statins-and-pancreatic-cancer-risk-a-population-based-case-control-study
#10
Pik Fang Kho, Jonathan Fawcett, Lin Fritschi, Harvey Risch, Penelope M Webb, David C Whiteman, Rachel E Neale
PURPOSE: Studies suggest that aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), and statins may reduce risk of some cancers. However, findings have been conflicting as to whether these agents reduce the risk of pancreatic cancer. METHODS: We used data from the Queensland Pancreatic Cancer Study, a population-based case-control study. In total, 704 cases and 711 age- and sex-matched controls were recruited. Participants completed an interview in which they were asked about history of NSAID and statin use...
November 5, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27807372/pancreatitis-cigarette-smoke-factor-aggravates-pancreatitis
#11
Charlotte Ridler
No abstract text is available yet for this article.
November 3, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27797938/leucocyte-telomere-length-genetic-variants-at-the-tert-gene-region-and-risk-of-pancreatic-cancer
#12
Ying Bao, Jennifer Prescott, Chen Yuan, Mingfeng Zhang, Peter Kraft, Ana Babic, Vicente Morales-Oyarvide, Zhi Rong Qian, Julie E Buring, Barbara B Cochrane, J Michael Gaziano, Edward L Giovannucci, JoAnn E Manson, Kimmie Ng, Shuji Ogino, Thomas E Rohan, Howard D Sesso, Meir J Stampfer, Charles S Fuchs, Immaculata De Vivo, Laufey T Amundadottir, Brian M Wolpin
OBJECTIVE: Telomere shortening occurs as an early event in pancreatic tumorigenesis, and genetic variants at the telomerase reverse transcriptase (TERT) gene region have been associated with pancreatic cancer risk. However, it is unknown whether prediagnostic leucocyte telomere length is associated with subsequent risk of pancreatic cancer. DESIGN: We measured prediagnostic leucocyte telomere length in 386 pancreatic cancer cases and 896 matched controls from five prospective US cohorts...
October 21, 2016: Gut
https://www.readbyqxmd.com/read/27782199/risk-factors-for-sporadic-pancreatic-neuroendocrine-tumors-a-case-control-study
#13
Qiwen Ben, Jie Zhong, Jian Fei, Haitao Chen, Lifen Yv, Jihong Tan, Yaozong Yuan
The current study examined risk factors for sporadic pancreatic neuroendocrine tumors (PNETs), including smoking, alcohol use, first-degree family history of any cancer (FHC), and diabetes in the Han Chinese ethnic group. In this clinic-based case-control analysis on 385 patients with sporadic PNETs and 614 age- and sex-matched controls, we interviewed subjects using a specific questionnaire on demographics and potential risk factors. An unconditional multivariable logistic regression analysis was used to estimate adjusted odds ratios (AORs)...
October 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27776049/frequency-of-tabagism-and-n34s-and-p55s-mutations-of-serine-peptidase-inhibitor-kazal-type-1-spink1-and-r254w-mutation-of-chymotrypsin-c-ctrc-in-patients-with-chronic-pancreatitis-and-controls
#14
Marianges Zadrozny Gouvêa da Costa, Júlia Glória Lucatelli Pires, Paulo Dominguez Nasser, Camila da Silva Ferreira, Ana Cristina de Sá Teixeira, Denise Cerqueira Paranaguá-Vezozzo, Dulce Reis Guarita, Flair José Carrilho, Suzane Kioko Ono
OBJECTIVE: This study aimed to investigate the association between chronic pancreatitis and smoking or genetic mutations. METHODS: The study sample comprised 148 patients with chronic pancreatitis, 110 chronic alcoholic subjects without pancreatic disease, and 297 volunteer blood donors. RESULTS: Of the patients with chronic pancreatitis, 74% had alcoholic etiology and 26% had idiopathic pancreatitis. The frequency of smoking was 91.4% in patients with alcoholic pancreatitis, higher than 73...
October 2016: Pancreas
https://www.readbyqxmd.com/read/27776047/the-chronic-pancreatitis-international-classification-of-diseases-ninth-revision-clinical-modification-code-577-1-is-inaccurate-compared-with-criterion-standard-clinical-diagnostic-scoring-systems
#15
Naveen G Reddy, Sharad Nangia, Matthew J DiMagno
OBJECTIVES: Epidemiological studies utilizing administrative databases use the International Classification of Diseases, Ninth Revision, Clinical Modification code (577.1) to identify patients with chronic pancreatitis (CP). We hypothesized that coding of CP in these databases is inaccurate. METHODS: We retrospectively reviewed the records of 1343 consecutive patients having an International Classification of Diseases, Ninth Revision, Clinical Modification code 577...
October 2016: Pancreas
https://www.readbyqxmd.com/read/27769811/aryl-hydrocarbon-receptor-ligands-in-cigarette-smoke-induce-production-of-interleukin-22-to-promote-pancreatic-fibrosis-in-models-of-chronic-pancreatitis
#16
Jing Xue, Qinglan Zhao, Vishal Sharma, Linh P Nguyen, Yvonne N Lee, Kim L Pham, Mouad Edderkaoui, Stephen J Pandol, Walter Park, Aida Habtezion
BACKGROUND & AIMS: Cigarette smoke has been identified as an independent risk factor for chronic pancreatitis (CP). Little is known about the mechanisms by which smoking promotes development of CP. We assessed the effects of aryl hydrocarbon receptor (AhR) ligands found in cigarette smoke on immune cell activation in humans and pancreatic fibrosis in animal models of CP. METHODS: We obtained serum samples from patients with CP treated at Stanford University hospital and healthy individuals (controls) and isolated CD4(+) T cells...
December 2016: Gastroenterology
https://www.readbyqxmd.com/read/27743227/cancer%C3%A2-survivorship-defining-the-incidence-of-incisional-hernia-after-resection-for-intra-abdominal-malignancy
#17
Rebeccah B Baucom, Jenny Ousley, Gloria B Beveridge, Sharon E Phillips, Richard A Pierce, Michael D Holzman, Kenneth W Sharp, William H Nealon, Benjamin K Poulose
BACKGROUND: Cancer survivorship focuses largely on improving quality of life. We aimed to determine the rate of ventral incisional hernia (VIH) formation after cancer resection, with implications for survivorship. METHODS: Patients without prior VIH who underwent abdominal malignancy resections at a tertiary center were followed up to 2 years. Patients with a viewable preoperative computed tomography (CT) scan and CT within 2 years postoperatively were included...
October 14, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27732944/germline-mutations-in-japanese-familial-pancreatic-cancer-patients
#18
Erina Takai, Shinichi Yachida, Kyoko Shimizu, Junji Furuse, Emi Kubo, Akihiro Ohmoto, Masami Suzuki, Ralph H Hruban, Takuji Okusaka, Chigusa Morizane, Toru Furukawa
Clinicopathologic and genetic features of familial pancreatic cancer (FPC) in Asian countries remain largely unknown. The main purpose of this study was to determine the prevalence of FPC and to define causative FPC-predisposition genes in a Japanese cohort with pancreatic ductal adenocarcinoma (PDAC).We reviewed 1,197 patients with a pathologically proven PDAC and found that 88 (7.3%) were FPC patients who had at least one first-degree relative with PDAC. There were no significant differences between the FPC cases and sporadic cases in terms of gender, age, tumor location, stage, family history of any cancer except PDAC, and personal history of smoking, other cancers, diabetes mellitus and chronic pancreatitis...
October 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27732623/obstructive-sleep-apnea-and-pathological-characteristics-of-resected-pancreatic-ductal-adenocarcinoma
#19
Marco Dal Molin, Aaron Brant, Amanda L Blackford, James F Griffin, Koji Shindo, Thomas Barkley, Neda Rezaee, Ralph H Hruban, Christopher L Wolfgang, Michael Goggins
BACKGROUND: Prospective studies have identified obstructive sleep apnea (OSA) as a risk factor for increased overall cancer incidence and mortality. The potential role of OSA in the risk or progression of specific cancers is not well known. We hypothesized that pathological differences in pancreatic cancers from OSA cases compared to non-OSA cases would implicate OSA in pancreatic cancer progression. METHODS: We reviewed the medical records of 1031 patients who underwent surgical resection without neoadjuvant therapy for pancreatic ductal adenocarcinoma (PDAC) at Johns Hopkins Hospital between 2003 and 2014 and compared the TNM classification of their cancer and their overall survival by patient OSA status...
2016: PloS One
https://www.readbyqxmd.com/read/27689194/single-nucleotide-polymorphisms-within-the-8q24-region-are-not-associated-with-the-risk-of-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#20
Nikola Panic, Alberto Larghi, Rosarita Amore, Roberta Pastorino, Milutin Bulajic, Guido Costamagna, Stefania Boccia
BACKGROUND AND AIMS: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have been reported to be associated with an increased risk of developing extra-pancreatic malignancies. A common genetic background has been hypothesised to be responsible for such an association. Human chromosomal region 8q24 has been associated with many types of cancer. The majority of these associations lie at approximately 128 Mb on chromosome 8. We conducted a study in order to examine the association between IPMN and single nucleotide polymorphisms (SNPs) from the 8q24 region, namely rs10505477, rs6983267, rs7014346, rs6993464, previously reported to influence general cancer susceptibility...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
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