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Smoking pancreatitis

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https://www.readbyqxmd.com/read/28991938/intraoral-lesion-%C3%A2-history-of-cirrhosis-and-smoking-%C3%A2-dx
#1
Ezinne I Ogbureke, Ruth E Conn, Dennis E Garcia, Cleverick D Johnson
A 56-year-old white man presented at our dental clinic for routine care. The intraoral examination revealed an asymptomatic red lesion with white vesicle-like areas on the right side of the soft palate. The extraoral examination was normal, and regional lymph nodes were nonpalpable. The patient's medical history included liver cirrhosis and pancreatitis. He also had a 30-year history of alcohol misuse (1-5 drinks per day) and a 30-pack-year smoking history. (The patient had stopped drinking at the time of presentation, and had quit smoking 2 years earlier...
October 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28988572/uniting-epidemiology-and-experimental-disease-models-for-alcohol-related-pancreatic-disease
#2
Veronica Wendy Setiawan, Kristine Monroe, Aurelia Lugea, Dhiraj Yadav, Stephen Pandol
Findings from epidemiologic studies and research with experimental animal models provide insights into alcohol-related disease pathogeneses. Epidemiologic data indicate that heavy drinking and smoking are associated with high rates of pancreatic disease. Less clear is the association between lower levels of drinking and pancreatitis. Intriguingly, a very low percentage of drinkers develop clinical pancreatitis. Experimental models demonstrate that alcohol administration alone does not initiate pancreatitis but does sensitize the pancreas to disease...
2017: Alcohol Research: Current Reviews
https://www.readbyqxmd.com/read/28982582/interplay-between-innate-immunity-and-iron-metabolism-after-acute-pancreatitis
#3
Shayal K Chand, Ruma G Singh, Sayali A Pendharkar, Sakina H Bharmal, Maxim S Petrov
Emerging evidence shows that chronic low-grade inflammation and changes in markers of innate immunity are implicated in a range of metabolic abnormalities following an episode of acute pancreatitis. Also, deranged iron metabolism has been linked to type 2 diabetes mellitus, gestational diabetes, and new-onset diabetes after pancreatitis - the conditions characterized by high haemoglobin glycation index (HGI). This study aimed to investigate the associations between markers of innate immunity and iron metabolism in individuals after acute pancreatitis...
October 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28974895/body-mass-index-does-not-affect-the-survival-of-pancreatic-cancer-patients
#4
Qing-Long Jiang, Cheng-Feng Wang, Yan-Tao Tian, Huang Huang, Shui-Sheng Zhang, Dong-Bing Zhao, Jie Ma, Wei Yuan, Yue-Min Sun, Xu Che, Jian-Wei Zhang, Yun-Mian Chu, Ya-Wei Zhang, Ying-Tai Chen
AIM: To evaluate the association of body mass index (BMI) with the overall survival of pancreatic ductal adenocarcinoma (PDAC) patients. METHODS: A retrospective analysis of PDAC patients diagnosed in the National Cancer Center of China between January 1999 and December 2014 was performed. These patients were categorized into four BMI groups (< 18.5, 18.5-22.9, 23-27.4 and ≥ 27.5 kg/m(2)). χ(2) tests for comparison of the proportions of categorical variables, and Student's t-test or Mann-Whitney test for continuous variables were employed...
September 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28969358/possible-role-of-diet-in-cancer-systematic-review-and-multiple-meta-analyses-of-dietary-patterns-lifestyle-factors-and-cancer-risk
#5
Giuseppe Grosso, Francesca Bella, Justyna Godos, Salvatore Sciacca, Daniele Del Rio, Sumantra Ray, Fabio Galvano, Edward L Giovannucci
Context: Evidence of an association between dietary patterns derived a posteriori and risk of cancer has not been reviewed comprehensively. Objective: The aim of this review was to investigate the relation between a posteriori-derived dietary patterns, grouped as healthy or unhealthy, and cancer risk. The relation between cancer risk and background characteristics associated with adherence to dietary patterns was also examined. Data Sources: PubMed and Embase electronic databases were searched...
June 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28968289/ctrc-genetic-variants-including-c-180tt-are-strongly-associated-with-chronic-pancreatitis-in-paediatric-patients
#6
Alicja Monika Grabarczyk, Grzegorz Oracz, Katarzyna Wertheim-Tysarowska, Aleksandra Anna Kujko, Karolina Wejnarska, Elwira Kolodziejczyk, Jerzy Bal, Dorota Koziel, Artur Kowalik, Stanislaw Gluszek, Agnieszka Magdalena Rygiel
Genetic studies in adults/adolescent patients with chronic pancreatitis (CP) identified chymotrypsinogen C (CTRC) genetic variants but their association with CP risk have been difficult to replicate. OBJECTIVE: To evaluate the risk of CP associated with CTRC variants in CP paediatric patients-control study. DESIGN: The distribution of CTRC variants in CP paediatric cohort (n = 136, median age at CP onset 8 years) with no history of alcohol/smoking abuse was compared to controls (n = 401, median age 45)...
September 29, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28961573/risk-factors-and-nomogram-for-common-bile-duct-stricture-in-chronic-pancreatitis-a-cohort-of-2153-patients
#7
Lu Hao, Ya-Wei Bi, Di Zhang, Xiang-Peng Zeng, Lei Xin, Jun Pan, Dan Wang, Jun-Tao Ji, Ting-Ting Du, Jin-Huan Lin, Bo Ye, Wen-Bin Zou, Hui Chen, Ting Xie, Bai-Rong Li, Zhao-Hong Zheng, Teng Wang, Hong-Lei Guo, Zhuan Liao, Zhao-Shen Li, Liang-Hao Hu
GOALS: To identify the risk factors and develop nomograms for common bile duct (CBD) stricture in chronic pancreatitis (CP) patients. BACKGROUND: CBD stricture is a common complication in CP and has a variable clinical presentation ranging from asymptomatic to overt jaundice and cholangitis. STUDY: Patients with CP admitted to Changhai Hospital (Shanghai, China) from January 2000 to December 2013 were enrolled. Cumulative rates of CBD stricture after onset and diagnosis of CP were calculated...
September 28, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28961214/cadmium-and-cadmium-zinc-ratios-and-tobacco-related-morbidities
#8
REVIEW
Patricia Richter, Obaid Faroon, R Steven Pappas
Metals are one of five major categories of carcinogenic or toxic constituents in tobacco and tobacco smoke. Cadmium is highly volatile and a higher percentage of the total tobacco cadmium content is efficiently transferred to mainstream tobacco smoke than many other toxic metals in tobacco. Inhaled cadmium bioaccumulates in the lungs and is distributed beyond the lungs to other tissues, with a total body biological half-life of one to two decades. Chronic cadmium exposure through tobacco use elevates blood and urine cadmium concentrations...
September 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28958690/relationship-between-circulating-levels-of-pancreatic-proteolytic-enzymes-and-pancreatic-hormones
#9
Sakina H Bharmal, Sayali A Pendharkar, Ruma G Singh, Mark O Goodarzi, Stephen J Pandol, Maxim S Petrov
BACKGROUND: While the close morphological relationship between the exocrine and endocrine pancreas is well established, their functional interaction remains poorly understood. The aim of this study was to investigate the associations between circulating levels of pancreatic proteolytic enzymes and insulin, as well as other pancreatic hormones. METHODS: Fasting venous blood samples were collected and analyzed for trypsin, chymotrypsin, insulin, glucagon, somatostatin, and pancreatic polypeptide...
September 20, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28935139/the-prevalence-of-underweight-is-increased-in-chronic-pancreatitis-outpatients-and-associates-with-reduced-life-quality
#10
Søren S Olesen, Louise Kuhlman Frandsen, Jakob Lykke Poulsen, Peter Vestergaard, Henrik Højgaard Rasmussen, Asbjørn M Drewes
BACKGROUND: Underweight is a well-known complication of chronic pancreatitis (CP), but little is known about its prevalence in the outpatient setting. We investigated the prevalence of underweight in outpatients with CP and its association with quality of life (QOL) and various risk factors. METHODS: This was a cross-sectional study of 166 outpatients with CP that was conducted at a tertiary referral center. The primary outcome was the prevalence of underweight (body mass index [BMI] <20 kg/m(2)) in patients with CP compared with 160 age- and sex-matched controls...
November 2017: Nutrition
https://www.readbyqxmd.com/read/28931509/development-and-validation-of-qmortality-risk-prediction-algorithm-to-estimate-short-term-risk-of-death-and-assess-frailty-cohort-study
#11
Julia Hippisley-Cox, Carol Coupland
Objectives To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission.Design Prospective open cohort study.Participants Routinely collected data from 1436 general practices contributing data to QResearch in England between 2012 and 2016. 1079 practices were used to develop the scores and a separate set of 357 practices to validate the scores. 1.47 million patients aged 65-100 years were in the derivation cohort and 0...
September 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28929489/association-between-long-term-low-intensity-cigarette-smoking-and-incidence-of-smoking-related-cancer-in-the-national-institutes-of-health-aarp-cohort
#12
Maki Inoue-Choi, Patricia Hartge, Linda M Liao, Neil Caporaso, Neal D Freedman
An increasing proportion of US smokers smoke ≤10 cigarettes per day (CPD) or do not smoke every day, yet the health effects of low-intensity smoking are poorly understood. We identified lifelong smokers of <1 or 1-10 CPD and evaluated risk of incident cancer among 238,525 cancer-free adults, aged 59-82, in the NIH-AARP Diet and Health Study. A questionnaire administered in 2004-2005 assessed CPD during nine age-periods (<15 to ≥70). We estimated hazard ratios (HR) and 95% confidence intervals (CI) using multivariable-adjusted Cox proportional hazards regression with age as the underlying time metric...
September 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28927476/antioxidant-intake-from-diet-and-supplements-and-risk-of-digestive-cancers-in-middle-aged-adults-results-from-the-prospective-nutrinet-sant%C3%A3-cohort
#13
Manon Egnell, Philippine Fassier, Lucie Lécuyer, Rebeca Gonzalez, Laurent Zelek, Marie-Paule Vasson, Serge Hercberg, Paule Latino-Martel, Pilar Galan, Nathalie Druesne-Pecollo, Mélanie Deschasaux, Mathilde Touvier
Experimental studies suggest beneficial effects of antioxidants in digestive cancer prevention. However, epidemiological results are contrasting and few studies quantitatively assessed supplemental intake. This study aimed at investigating the associations between antioxidant intakes (dietary, supplemental and total) and digestive cancer risk. This prospective study included 38 812 middle-aged subjects (≥45 years) from the NutriNet-Santé cohort (2009-2016). Dietary data were collected using repeated 24 h records...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28921575/ingested-nitrate-and-nitrite-disinfection-by-products-and-pancreatic-cancer-risk-in-postmenopausal-women
#14
Arbor J L Quist, Maki Inoue-Choi, Peter J Weyer, Kristin E Anderson, Kenneth P Cantor, Stuart Krasner, Laura E Beane Freeman, Mary H Ward, Rena R Jones
Nitrate and nitrite are precursors of N-nitroso compounds (NOC), probable human carcinogens that cause pancreatic tumors in animals. Disinfection by-products (DBP) exposures have also been linked with digestive system cancers, but few studies have evaluated relationships with pancreatic cancer. We investigated the association of pancreatic cancer with these drinking water contaminants and dietary nitrate/nitrite in a cohort of postmenopausal women in Iowa (1986-2011). We used historical monitoring and treatment data to estimate levels of long-term average nitrate and total trihalomethanes (TTHM; the sum of the most prevalent DBP class) and the duration exceeding one-half the maximum contaminant level (>½ MCL; nitrate-nitrogen 5mg/L, 40µg/L TTHM) among participants on public water supplies (PWS) >10 years...
September 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28903383/association-between-abo-blood-types-and-sporadic-pancreatic-neuroendocrine-tumors-in-the-chinese-han-population
#15
Qiwen Ben, Jun Liu, Weiyi Wang, Fang Guo, Weiyan Yao, Jie Zhong, Yaozong Yuan
BACKGROUND: Although the relationship between non-O blood types and the risk of exocrine pancreatic cancer has been demonstrated, the association between ABO blood types and sporadic pancreatic neuroendocrine tumor (PNET) has not been reported thus far. METHODS: This hospital-based, case-control study included 387 patients with PNET and 542 age- and sex-matched controls. Unconditional multivariable logistic regression analysis was performed to estimate the adjusted odds ratios (AORs) and 95% confidence intervals (CIs)...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28885865/changes-in-insurance-coverage-and-stage-at-diagnosis-among-nonelderly-patients-with-cancer-after-the-affordable-care-act
#16
Ahmedin Jemal, Chun Chieh Lin, Amy J Davidoff, Xuesong Han
Purpose To examine change in the percent uninsured and early-stage diagnosis among nonelderly patients with newly diagnosed cancer after the Affordable Care Act (ACA). Patients and Methods By using the National Cancer Data Base, we estimated absolute change (APC) and relative change in percent uninsured among patients with newly diagnosed cancer age 18 to 64 years between 2011 to the third quarter of 2013 (pre-ACA implementation) and the second to fourth quarter of 2014 (post-ACA) in Medicaid expansion and nonexpansion states by family income level...
September 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28882992/novel-pathways-of-ponatinib-disposition-catalyzed-by-cyp1a1-involving-generation-of-potentially-toxic-metabolites
#17
De Lin, Rumen Kostov, Jeffrey T-J Huang, Colin J Henderson, C Roland Wolf
Ponatinib, a pan-BCR-ABL tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia (CML), causes severe side effects including vascular occlusions, pancreatitis, and liver toxicity, although the underlying mechanisms remain unclear. Modifications of critical proteins through reactive metabolites are thought to be responsible for a number of adverse drug reactions. In vitro metabolite screening of ponatinib with human liver microsomes and glutathione revealed unambiguous signals of ponatinib-glutathione (P-GSH) adducts...
October 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28880010/chronic-pancreatitis
#18
REVIEW
Jorg Kleeff, David C Whitcomb, Tooru Shimosegawa, Irene Esposito, Markus M Lerch, Thomas Gress, Julia Mayerle, Asbjørn Mohr Drewes, Vinciane Rebours, Fatih Akisik, J Enrique Domínguez Muñoz, John P Neoptolemos
Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the pancreas in individuals with genetic, environmental and/or other risk factors who develop persistent pathological responses to parenchymal injury or stress. Potential causes can include toxic factors (such as alcohol or smoking), metabolic abnormalities, idiopathic mechanisms, genetics, autoimmune responses and obstructive mechanisms. The pathophysiology of chronic pancreatitis is fairly complex and includes acinar cell injury, acinar stress responses, duct dysfunction, persistent or altered inflammation, and/or neuro-immune crosstalk, but these mechanisms are not completely understood...
September 7, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28876645/is-hiv-status-relevant-in-acute-pancreatitis
#19
L A Prodehl, M B Brand, M Mauser
BACKGROUND: HIV positivity and antiretroviral (ARV) treatment have been described as significant causes of acute pancreatitis prevalence and predictors of poor outcomes. Most data are from the late 1990s and early 2000s, prior to widespread roll out of ARVs and newer agents. This study assessed if there is still a significant difference between HIV positive (HIV+) and negative(HIV-) patients in acute pancreatitis in the presentation and outcomes of acute pancreatitis. METHOD: A retrospective review of a prospectively collected database of patient admission data...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28872147/generation-of-a-chronic-obstructive-pulmonary-disease-model-in-mice-by-repeated-ozone-exposure
#20
Zhongwei Sun, Feng Li, Xin Zhou, Wen Wang
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and lung parenchymal destruction. It has a very high incidence in aging populations. The current conventional therapies for COPD focus mainly on symptom-modifying drugs; thus, the development of new therapies is urgently needed. Qualified animal models of COPD could help to characterize the underlying mechanisms and can be used for new drug screening. Current COPD models, such as lipopolysaccharide (LPS) or the porcine pancreatic elastase (PPE)-induced emphysema model, generate COPD-like lesions in the lungs and airways but do not otherwise resemble the pathogenesis of human COPD...
August 25, 2017: Journal of Visualized Experiments: JoVE
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