Murat Dogan, Christine Watkins, Holly Ingram, Nicholas Moore, Grace M Rucker, Elizabeth G Gower, James D Eason, Anshul Bhalla, Manish Talwar, Nosratollah Nezakatgoo, Corey Eymard, Ryan Helmick, Jason Vanatta, Amandeep Bajwa, Canan Kuscu, Cem Kuscu
INTRODUCTION: Apolipoprotein-L1 (APOL1) is a primate-specific protein component of high- density lipoprotein (HDL). Two variants of APOL1 (G1 and G2), provide resistance to parasitic infections in African Americans but are also implicated in kidney-related diseases and transplant outcomes in recipients. This study aims to identify these risk variants using a novel probe- independent quantitative real-time PCR method in a high African American recipient cohort. Additionally, it aims to develop a new stratification approach based on haplotype-centric model...
October 19, 2023: bioRxiv