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kidney transplant&infection&polymorphism

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https://www.readbyqxmd.com/read/27800130/the-association-between-viral-infections-and-co-stimulatory-gene-polymorphisms-in-kidney-transplant-outcomes
#1
Ahmad Niknam, Mohammad Hossein Karimi, Ramin Yaghobi, Bita Geramizadeh, Jamshid Roozbeh, Mehdi Salehipour, Mahdiyar Iravani
BACKGROUND: The surveillance of kidney transplant patients depends on function of different immunologic markers like co-stimulatory molecules. These molecules may also be associated with post kidney transplant viral related outcomes. OBJECTIVES: The aim of this study was to investigate the possible associations between co-stimulatory molecule gene polymorphisms and viral infections in kidney transplant patients. PATIENTS AND METHODS: In total, 172 kidney transplant patients were included in this study...
August 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27350315/kidney-allograft-telomere-length-is-not-associated-with-sex-recipient-comorbid-conditions-post-transplant-infections-or-cmv-reactivation
#2
Karolina Kłoda, Leszek Domański, Ewa Kwiatkowska, Krzysztof Safranow, Arleta Drozd, Andrzej Ciechanowicz, Kazimierz Ciechanowski
BACKGROUND Immunosenescence is closely linked to chromosome telomere erosion and telomerase activity alterations. The aim of this study was to analyze the associations of relative telomere length (RTL) of a graft with sex, comorbid conditions, post-transplant infections, and CMV reactivation among transplanted kidney recipients. Additionally, the associations of donor and recipient hTERT, BICD1 genes and chromosome 18 polymorphisms with post-transplant infections were analyzed, including the analysis of donor-recipient genotype pairs...
2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27232286/first-line-use-of-rituximab-correlates-with-increased-overall-survival-in-late-post-transplant-lymphoproliferative-disorders-retrospective-single-centre-study
#3
Nicolás Martínez-Calle, Ana Alfonso, José Rifón, Ignacio Herrero, Pedro Errasti, Gregorio Rábago, Juana Merino, Ángel Panizo, Javier Pardo, Felipe Prósper, Ricardo García-Muñoz, Ramón Lecumberri, Carlos Panizo
This retrospective study evaluates the impact of rituximab on PTLD response and survival in a single-centre cohort. PTLD cases between 1984 and 2009, including heart, kidney, liver and lung transplant recipients, were included. Survival was analysed taking into account the type of PTLD (monomorphic vs. polymorphic), EBV infection status, IPI score, Ann Arbor stage and use of rituximab. Among 1335 transplanted patients, 24 developed PTLD. Median age was 54 yr (range 29-69), median time to diagnosis 50 months (range 0-100)...
May 27, 2016: European Journal of Haematology
https://www.readbyqxmd.com/read/27109946/kidney-transplantation-polymorphisms-of-il-18-and-other-pro-inflammatory-genes-and-late-post-transplant-outcome
#4
D Piancatelli, D Maccarone, A Colanardi, P Sebastiani, K Clemente, S Iesari, V Di Pietro, Q Lai, A Famulari, F Pisani
BACKGROUND: Functional polymorphisms of molecules involved in immune-mediated mechanisms of allograft rejection could be predictive of increased risk for early and late post-transplant complications. In the past years, the challenge for long-term graft survival in kidney recipients is the implementation of personalized approaches. In this study, effects of interleukin (IL)-18-137G/C (rs187238), -607C/A (rs1946518), and other pro-inflammatory cytokine gene polymorphisms (tumor necrosis factor [TNF]-α-308G/A, rs1800629, IL-6-174G/C, rs1800795, and interferon [IFN]-γ+874A/T, rs2430561) on the main post-transplant risk parameters and diseases (metabolic, cardiovascular, infective, and chronic allograft rejection) were assessed in kidney-transplanted patients...
March 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27082871/monitoring-the-intracellular-tacrolimus-concentration-in-kidney-transplant-recipients-with-stable-graft-function
#5
Seung Seok Han, Seung Hee Yang, Min Chang Kim, Joo-Youn Cho, Sang-Il Min, Jung Pyo Lee, Dong Ki Kim, Jongwon Ha, Yon Su Kim
Although monitoring the intracellular concentration of immunosuppressive agents may be a promising approach to individualizing the therapy after organ transplantation, additional studies on this issue are needed prior to its clinical approval. We investigated the relationship between intracellular and whole blood concentrations of tacrolimus (IC-TAC and WB-TAC, respectively), the factors affecting this relationship, and the risk of rejection based upon IC-TAC in stable kidney recipients. Both IC-TAC and WB-TAC were measured simultaneously in 213 kidney recipients with stable graft function using LC-MS/MS...
2016: PloS One
https://www.readbyqxmd.com/read/26849829/apol1-polymorphisms-in-a-deceased-donor-and-early-presentation-of-collapsing-glomerulopathy-and-focal-segmental-glomerulosclerosis-in-two-recipients
#6
P B Shah, J E Cooper, M S Lucia, C Boils, C P Larsen, A C Wiseman
Two common polymorphisms in APOL1 (G1 and G2) are conserved in persons of African ancestry, and the presence of two polymorphisms (commonly referred to as risk variants) has been identified as a risk factor for chronic kidney disease and focal seg-mental glomerulosclerosis. In kidney transplantation, deceased donors with two APOL1 risk variants carry an increased risk of renal allograft failure in the recipient. An emerging question is whether these data should influence deceased donor assessment or be used to refine prediction of allograft survival...
June 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/26207164/voriconazole-and-the-liver
#7
Romeo-Gabriel Mihăilă
Voriconazole is an azole useful for the prophylaxis and the treatment of aspergillosis and other fungal infections in immunosuppressed subjects, as those found in aplasia after aggressive polychemotherapy treatments, after hematopoietic stem cell, liver or lung transplantation. Its administration in therapeutic doses lead to extremely varied serum levels from patient to patient and even to the same patient. The explanations are varied: nonlinear pharmacokinetics, certain patient-related factors, including genetic polymorphisms in the cytochrome P450 2C19 gene, the kidney and liver function, simultaneous administration with other drugs metabolised by the same cytochrome...
July 18, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/26177348/comparison-of-tacrolimus-and-cyclosporin-a-in-cyp3a5-expressing-chinese-de-novo-kidney-transplant-recipients-a-2-year-prospective-study
#8
L-S Liu, J Li, X-T Chen, H-X Zhang, Q Fu, H-Y Wang, Y-Y Xiong, S Liu, X-M Liu, J-L Li, M Huang, C-X Wang
AIMS: To assess the efficacy and safety of tacrolimus and cyclosporin A (CsA)-based immunosuppressive regimens in Chinese de novo kidney transplant recipients who are CYP3A5 expressers. METHODS: The CYP3A5 (6986 A>G, rs776746) polymorphism of eligible patients was determined before transplantation. De novo kidney transplant recipients enrolled in this study were assigned to tacrolimus (Tac group) or CsA (CsA group) based therapy. The follow-up period was 2 years...
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/26125894/association-of-cytokine-gene-polymorphisms-with-susceptibility-to-invasive-candidiasis
#9
R T Sun, W J Tian, X W Xing, S H Gao, S B Wang
The aim of this study was to investigate the role of cytokine genes in the susceptibility to Candida infection. A total of 275 consecutive patients diagnosed with Candida infection were selected between May 2010 and May 2011, along with 305 uninfected controls. Genotyping of the IL-1β gene polymorphisms (IL1β) rs1143634, IL1βrs16944, IL8 rs4073, IL10 rs1800872, and IL10 rs1800896 was carried out using a 384-well plate format on the Sequenom MassARRAY platform. Patients with invasive Candida infections were more likely to have had an immunocompromised state, hematopoietic stem cell transplantation, solid organ transplant, solid tumor, chemotherapy within the past three months, neutropenia, surgery within the past 30 days, acute renal failure, liver failure, and/or median baseline serum creatinine...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26107754/association-of-snps-with-the-efficacy-and-safety-of-immunosuppressant-therapy-after-heart-transplantation
#10
Ignacio Sánchez-Lázaro, María José Herrero, Consuelo Jordán-De Luna, Virginia Bosó, Luis Almenar, Luis Rojas, Luis Martínez-Dolz, Juan E Megías-Vericat, Luis Sendra, Antonio Miguel, José L Poveda, Salvador F Aliño
AIM: Studying the possible influence of SNPs on efficacy and safety of calcineurin inhibitors upon heart transplantation. MATERIALS & METHODS: In 60 heart transplant patients treated with tacrolimus or cyclosporine, we studied a panel of 36 SNPs correlated with a series of clinical parameters during the first post-transplantation year. RESULTS: The presence of serious infections was correlated to ABCB1 rs1128503 (p = 0.012), CC genotype reduced the probability of infections being also associated with lower blood cyclosporine concentrations...
2015: Pharmacogenomics
https://www.readbyqxmd.com/read/25966085/benefits-of-minimizing-immunosuppressive-dosage-according-to-cytochrome-p450-3a5-genotype-in-liver-transplant-patients-findings-from-a-single-center-study
#11
L Wang, N Li, M X Wang, S C Lu
We evaluated the clinical efficacy of tailoring tacrolimus dosage to cytochrome P450 (CYP) 3A5 genotype in liver transplant patients. One hundred patients who received tacrolimus-based therapy were included in the retrospective study in which the relationship between the tacrolimus blood trough concentration/dosage ratio and the CYP3A5 genotype of both donors and recipients was determined. Subsequently, 106 patients were continuously enrolled in a prospective study and followed-up for 6 months; the relationship between tacrolimus dosage and CYP3A5 genotype was also determined...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25951705/-reccurent-clostridium-difficile-infection-in-patient-after-kidney-transplantation-on-rituximab-therapy-due-to-ptld-post-transplant-lymphoprolipherative-disorder-first-experience-with-fidaxomicin-use-case-report
#12
Dominik Cieniawski, Ewa Ignacak, Alina Bętkowska-Prokop, Barbara Dudzik, Bogusław Walatek, Marek Kuźniewski, Władysław Sułowicz
Clostridium difficile infection (CDI) is an increasingly problem in everyday clinical practice. The most important risk factor of this infection is antibiotics use. The incidence of Clostridium difficile associated diarrhea (CDAD) in patients after renal transplantation is estimated to be about 6% in the early postoperative period. Due to the applied immunosuppression and frequent infections requiring intensive, broad spectral antibiotics, the later prevalence of CDAD may remain at a similar level. Massive diarrhea caused by Clostridium difficile may lead to fluctuations in immunosuppressive drugs concentration, in renal transplant patients...
2014: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/25861431/prevalence-and-distribution-of-bk-virus-subtypes-in-renal-transplant-recipients-referred-to-golestan-hospital-in-ahvaz-iran
#13
Gholam Abbas Kaydani, Manoochehr Makvandi, Alireza Samarbafzadeh, Heshmatollah Shahbazian, Mojtaba Hamidi Fard
BACKGROUND: BK virus (BKV) belongs to the human Polyomaviridae and the primary BKV infection is occurred during childhood then the virus could be latent through life, especially in the kidneys and urinary system. It became reactive after an immunocompromised status, such as pregnancy or transplantation. Isolated BKV from different locations of the world is grouped into four subtypes using serological and genotyping methods. The BKV subtype I is the dominant one and has worldwide distribution...
March 2015: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/25777542/association-between-individual-and-combined-snps-in-genes-related-to-innate-immunity-and-incidence-of-cmv-infection-in-seropositive-kidney-transplant-recipients
#14
M Fernández-Ruiz, I Corrales, M Arias, J M Campistol, E Giménez, J Crespo, M O López-Oliva, I Beneyto, P L Martín-Moreno, F Llamas-Fuente, A Gutiérrez, T García-Álvarez, R Guerra-Rodríguez, N Calvo, A Fernández-Rodríguez, J M Tabernero-Romo, M D Navarro, A Ramos-Verde, J M Aguado, D Navarro
In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved in orchestrating the immune response against cytomegalovirus (CMV) and the 12-month incidence of CMV infection in 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. CMV infection occurred in 140 patients (44.4%), including 13 episodes of disease. After adjusting for various clinical covariates, patients harboring T-allele genotypes of interleukin-28B (IL28B) (rs12979860) SNP had lower incidence of CMV infection (adjusted hazard ratio [aHR]: 0...
May 2015: American Journal of Transplantation
https://www.readbyqxmd.com/read/25546796/7-th-international-immunoglobulin-conference-poster-presentations
#15
K Warnatz, M Ballow, M Stangel, V Bril
Immunoglobulin (Ig) therapy is the mainstay of treatment for primary antibody deficiency disorders and has proved to be efficacious in specific autoimmune and inflammatory diseases. Additionally, due to the role of Ig in complement activation, it is being used increasingly in solid organ transplantation. Furthermore, Ig is the primary or secondary treatment in some immune-mediated neuropathies such as chronic inflammatory demyelinating polyneuropathy (CIDP) or multifocal motor neuropathy (MMN). This session discusses trends of Ig use in Europe, proposed mechanisms of action, adverse effects and the potential role of Ig therapy in transplantation...
December 2014: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/25398456/il1b-and-defb1-polymorphisms-increase-susceptibility-to-invasive-mold-infection-after-solid-organ-transplantation
#16
Agnieszka Wójtowicz, Mark S Gresnigt, Thanh Lecompte, Stephanie Bibert, Oriol Manuel, Leo A B Joosten, Sina Rüeger, Christoph Berger, Katia Boggian, Alexia Cusini, Christian Garzoni, Hans H Hirsch, Maja Weisser, Nicolas J Mueller, Pascal R Meylan, Jürg Steiger, Zoltan Kutalik, Manuel Pascual, Christian van Delden, Frank L van de Veerdonk, Pierre-Yves Bochud
BACKGROUND: Single-nucleotide polymorphisms (SNPs) in immune genes have been associated with susceptibility to invasive mold infection (IMI) among hematopoietic stem cell but not solid-organ transplant (SOT) recipients. METHODS: Twenty-four SNPs from systematically selected genes were genotyped among 1101 SOT recipients (715 kidney transplant recipients, 190 liver transplant recipients, 102 lung transplant recipients, 79 heart transplant recipients, and 15 recipients of other transplants) from the Swiss Transplant Cohort Study...
May 15, 2015: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/25356901/cytotoxic-t-lymphocyte-antigen-4-gene-polymorphism-influences-the-incidence-of-symptomatic-human-cytomegalovirus-infection-after-renal-transplantation
#17
Maneesh K Misra, Shashi K Pandey, Rakesh Kapoor, Raj K Sharma, Suraksha Agrawal
BACKGROUND: The role of CTLA4 gene polymorphisms in T-cell-mediated immunity in association with human cytomegalovirus (HCMV) infection after transplantation is poorly understood. In the present study, we have made an attempt to investigate the impact of CTLA4 single nucleotide polymorphisms (SNPs) (rs231775, rs5742909, rs11571317, rs16840252, rs4553808, rs3087243) and dinucleotide (AT)n repeat polymorphism on the incidence of symptomatic HCMV infection (disease) among 270 renal allograft recipients...
January 2015: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/25301956/influence-of-ifnl3-4-polymorphisms-on-the-incidence-of-cytomegalovirus-infection-after-solid-organ-transplantation
#18
MULTICENTER STUDY
Oriol Manuel, Agnieszka Wójtowicz, Stéphanie Bibert, Nicolas J Mueller, Christian van Delden, Hans H Hirsch, Juerg Steiger, Martin Stern, Adrian Egli, Christian Garzoni, Isabelle Binet, Maja Weisser, Christoph Berger, Alexia Cusini, Pascal Meylan, Manuel Pascual, Pierre-Yves Bochud
BACKGROUND: Polymorphisms in IFNL3 and IFNL4, the genes encoding interferon λ3 and interferon λ4, respectively, have been associated with reduced hepatitis C virus clearance. We explored the role of such polymorphisms on the incidence of cytomegalovirus (CMV) infection in solid-organ transplant recipients. METHODS: White patients participating in the Swiss Transplant Cohort Study in 2008-2011 were included. A novel functional TT/-G polymorphism (rs368234815) in the CpG region upstream of IFNL3 was investigated...
March 15, 2015: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/25253288/killer-immunoglobulin-like-receptor-gene-repertoire-influences-viral-load-of-primary-human-cytomegalovirus-infection-in-renal-transplant-patients
#19
D C Jones, S Peacock, D Hughes, J A Traherne, R L Allen, M C N M Barnardo, P Friend, C J Taylor, S Fuggle, J Trowsdale, N T Young
Killer cell immunoglobulin-like receptors (KIR) are highly polymorphic members of the immunoglobulin superfamily, which influence the response of natural killer cells and some T-lymphocyte subsets. Analysis of a cohort of previously human cytomegalovirus (HCMV)-negative patients, who developed primary HCMV infection following HCMV-positive renal transplant (n=76), revealed an increase in the frequency of KIR genes located on the telomeric region of B haplotypes (Tel B). The presence of Tel B in combination with the KIR ligand HLA-C2 was significantly more frequent in this subgroup...
December 2014: Genes and Immunity
https://www.readbyqxmd.com/read/25208755/interferon-gamma-gene-polymorphism-874-a-t-is-associated-with-an-increased-risk-of-cytomegalovirus-infection-among-hispanic-renal-transplant-recipients
#20
D Vu, T Shah, J Ansari, P Sakharkar, Q Yasir, R Naraghi, I Hutchinson, D Min
BACKGROUND: Cytomegalovirus (CMV) is the most common cause of viral infection, causing morbidity and mortality among renal transplant recipients (RTRs). Cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), and interferon-gamma (IFN-γ) have been shown to possess antiviral properties, and their polymorphisms are associated with disease outcome. The aim was to investigate the association of gene polymorphisms in IL-10, IFN-γ, and TNF-α with CMV infection in RTRs...
October 2014: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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