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adult cardiomyocyte proliferation

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https://www.readbyqxmd.com/read/27882462/proliferative-potential-of-cardiomyocytes-in-hypertrophic-cardiomyopathy-correlation-with-myocardial-remodeling
#1
T V Sukhacheva, Yu A Chudinovskikh, M V Eremeeva, R A Serov, L A Bockeria
Proliferating Ki-67(+) cardiomyocytes were detected in the interventricular septum myocardium of adult patients with hypertrophic cardiomyopathy. In the same patients, the severity of hypertrophy and the degree of cardiomyocyte differentiation were assessed by the content of myofibrils, ultrastructural morphology, and the pattern of connexin 43-containing gap junction distribution. Adult Ki-67(+) cardiomyocytes containing sarcomeric α-actin (sarc α-act(+)) in the sarcoplasm (diameter 23.9±6.9 μ) were detected in the myocardium of patients with hypertrophic cardiomyopathy; their relative content varied from 2 to 3084 cells per 1 million cardiomyocytes...
November 23, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27875683/redox-paradox-can-hypoxia-heal-ischemic-hearts
#2
Nuno Guimarães-Camboa, Sylvia M Evans
Adult cardiomyocytes are largely thought to lack proliferative and therefore regenerative potential. Reporting in Nature, Nakada et al. (2016) find that a hypoxic regime reduces mitochondrial metabolism and promotes proliferation in adult mouse cardiomyocytes, resulting in increased regeneration following myocardial infarction. These findings suggest the potential to transform post-MI care.
November 21, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27872447/evolving-approaches-to-heart-regeneration-by-therapeutic-stimulation-of-resident-cardiomyocyte-cell-cycle
#3
Raife Dilek Turan, Galip Servet Aslan, Doğacan Yücel, Remziye Döğer, Fatih Kocabaş
Heart has long been considered a terminally differentiated organ. Recent studies, however, have suggested that there is a modest degree of cardiomyocyte (CM) turnover in adult mammalian heart, albeit not sufficient for replacement of lost CMs following cardiac injuries. Cardiac regeneration studies in various model organisms including zebrafish, newt, and more recently in neonatal mouse, have demonstrated that CM dedifferentiation and concomitant proliferation play important roles in replacement of lost CMs and restoration of cardiac contractility...
November 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27832814/obesity-induced-cardiac-lipid-accumulation-in-adult-mice-is-modulated-by-g-protein-coupled-receptor-kinase-2-levels
#4
Elisa Lucas, Rocio Vila-Bedmar, Alba C Arcones, Marta Cruces-Sande, Victoria Cachofeiro, Federico Mayor, Cristina Murga
BACKGROUND: The leading cause of death among the obese population is heart failure and stroke prompted by structural and functional changes in the heart. The molecular mechanisms that underlie obesity-related cardiac remodeling are complex, and include hemodynamic and metabolic alterations that ultimately affect the functionality of the myocardium. G protein-coupled receptor kinase 2 (GRK2) is an ubiquitous kinase able to desensitize the active form of several G protein-coupled receptors (GPCR) and is known to play an important role in cardiac GPCR modulation...
November 10, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27812722/cardiomyocyte-proliferation-in-zebrafish-and-mammals-lessons-for-human-disease
#5
REVIEW
Gianfranco Matrone, Carl S Tucker, Martin A Denvir
Cardiomyocytes proliferate profusely during early development and for a brief period after birth in mammals. Within a month after birth, this proliferative capability is dramatically reduced in mammals unlike lower vertebrates where it persists into adult life. The zebrafish, for example, retains the ability to regenerate the apex of the heart following resection by a mechanism predominantly driven by cardiomyocyte proliferation. Differences in proliferative capacity of cardiomyocytes in adulthood between mammals and lower vertebrates are closely liked to ontogenetic or phylogenetic factors...
November 3, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27799944/repair-injured-heart-by-regulating-cardiac-regenerative-signals
#6
REVIEW
Wen-Feng Cai, Guan-Sheng Liu, Lei Wang, Christian Paul, Zhi-Li Wen, Yigang Wang
Cardiac regeneration is a homeostatic cardiogenic process by which the sections of malfunctioning adult cardiovascular tissues are repaired and renewed employing a combination of both cardiomyogenesis and angiogenesis. Unfortunately, while high-quality regeneration can be performed in amphibians and zebrafish hearts, mammalian hearts do not respond in kind. Indeed, a long-term loss of proliferative capacity in mammalian adult cardiomyocytes in combination with dysregulated induction of tissue fibrosis impairs mammalian endogenous heart regenerative capacity, leading to deleterious cardiac remodeling at the end stage of heart failure...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27798600/hypoxia-induces-heart-regeneration-in-adult-mice
#7
Yuji Nakada, Diana C Canseco, SuWannee Thet, Salim Abdisalaam, Aroumougame Asaithamby, Celio X Santos, Ajay Shah, Hua Zhang, James E Faber, Michael T Kinter, Luke I Szweda, Chao Xing, Ralph Deberardinis, Orhan Oz, Zhigang Lu, Cheng Cheng Zhang, Wataru Kimura, Hesham A Sadek
The adult mammalian heart is incapable of regeneration following cardiomyocyte loss, which underpins the devastating impact of cardiomyopathy. Recently, it has become clear that the mammalian heart is not a post-mitotic organ. For example, the neonatal heart is capable of regenerating lost myocardium(1), and the adult heart is capable of modest self-renewal(2,3). In both these scenarios, cardiomyocyte renewal occurs through proliferation of pre-existing cardiomyocytes, and is regulated by aerobic respiration-mediated oxidative DNA damage(4,5)...
October 31, 2016: Nature
https://www.readbyqxmd.com/read/27752085/myc-overexpression-enhances-of-epicardial-contribution-to-the-developing-heart-and-promotes-extensive-expansion-of-the-cardiomyocyte-population
#8
Cristina Villa Del Campo, Ghislaine Lioux, Rita Carmona, Rocío Sierra, Ramón Muñoz-Chápuli, Cristina Clavería, Miguel Torres
Myc is an essential regulator of cell growth and proliferation. Myc overexpression promotes the homeostatic expansion of cardiomyocyte populations by cell competition, however whether this applies to other cardiac lineages remains unknown. The epicardium contributes signals and cells to the developing and adult injured heart and exploring strategies for modulating its activity is of great interest. Using inducible genetic mosaics, we overexpressed Myc in the epicardium and determined the differential expansion of Myc-overexpressing cells with respect to their wild type counterparts...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27695872/understanding-cardiomyocyte-proliferation-an-insight-into-cell-cycle-activity
#9
Murugavel Ponnusamy, Pei-Feng Li, Kun Wang
Cardiomyocyte proliferation and regeneration are key to the functional recovery of myocardial tissue from injury. In the recent years, studies on cardiomyocyte proliferation overturned the traditional belief that adult cardiomyocytes permanently withdraw from the cell cycle activity. Hence, targeting cardiomyocyte proliferation is one of the potential therapeutic strategies for myocardial regeneration and repair. To achieve this, a deep understanding of the fundamental mechanisms involved in cardiomyocyte cell cycle as well as differences between neonatal and adult cardiomyocytes' cell cycle activity is required...
September 30, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27694478/role-of-fen1-s187-phosphorylation-in-counteracting-oxygen-induced-stress-and-regulating-postnatal-heart-development
#10
Lina Zhou, Huifang Dai, Jian Wu, Mian Zhou, Hua Yuan, Juan Du, Lu Yang, Xiwei Wu, Hong Xu, Yuejin Hua, Jian Xu, Li Zheng, Binghui Shen
Flap endonuclease 1 (FEN1) phosphorylation is proposed to regulate the action of FEN1 in DNA repair as well as Okazaki fragment maturation. However, the biologic significance of FEN1 phosphorylation in response to DNA damage remains unknown. Here, we report an in vivo role for FEN1 phosphorylation, using a mouse line carrying S187A FEN1, which abolishes FEN1 phosphorylation. Although S187A mouse embryonic fibroblast cells showed normal proliferation under low oxygen levels (2%), the mutant cells accumulated oxidative DNA damage, activated DNA damage checkpoints, and showed G1 phase arrest at atmospheric oxygen levels (21%)...
September 30, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27689781/poly-3-hydroxyoctanoate-a-promising-new-material-for-cardiac-tissue-engineering
#11
Andrea V Bagdadi, Maryam Safari, Prachi Dubey, Pooja Basnett, Panagiotis Sofokleous, Eleanor Humphrey, Ian Locke, Mohan Edirisinghe, Cesare Terracciano, Aldo R Boccaccini, Jonathan C Knowles, Sian E Harding, Ipsita Roy
Cardiac tissue engineering (CTE) is currently a prime focus of research due to an enormous clinical need. In this work, a novel functional material, Poly(3-hydroxyoctanoate), P(3HO), a medium chain length polyhydroxyalkanoate (PHA), produced using bacterial fermentation, was studied as a new potential material for CTE. Engineered constructs with improved mechanical properties, crucial for supporting the organ during new tissue regeneration, and enhanced surface topography, to allow efficient cell adhesion and proliferation, were fabricated...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27622691/single-cell-transcriptome-and-epigenomic-reprogramming-of-cardiomyocyte-derived-cardiac-progenitor-cells
#12
COMMENT
Xin Chen, Tushar Chakravarty, Yiqiang Zhang, Xiaojin Li, Jiang F Zhong, Charles Wang
The molecular basis underlying the dedifferentiation of mammalian adult cardiomyocytes (ACMs) into myocyte-derived cardiac progenitor cells (mCPCs) during cardiac tissue regeneration is poorly understood. We present data integrating single-cell transcriptome and whole-genome DNA methylome analyses of mouse mCPCs to understand the epigenomic reprogramming governing their intrinsic cellular plasticity. Compared to parental cardiomyocytes, mCPCs display epigenomic reprogramming with many differentially-methylated regions, both hypermethylated and hypomethylated, across the entire genome...
September 13, 2016: Scientific Data
https://www.readbyqxmd.com/read/27599529/heart-development-diseases-and-regeneration%C3%A3-new-approaches-from-innervation-fibroblasts-and-reprogramming
#13
Masaki Ieda
It is well known that cardiac function is tightly controlled by neural activity; however, the molecular mechanism of cardiac innervation during development and the relationship with heart disease remain undetermined. My work has revealed the molecular networks that govern cardiac innervation and its critical roles in heart diseases such as silent myocardial ischemia and arrhythmias. Cardiomyocytes proliferate during embryonic development, but lose their proliferative capacity after birth. Cardiac fibroblasts are a major source of cells during fibrosis and induce cardiac hypertrophy after myocardial injury in the adult heart...
September 23, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27591224/tnf-receptor-signaling-inhibits-cardiomyogenic-differentiation-of-cardiac-stem-cells-and-promotes-a-neuroadrenergic-like-fate
#14
Tariq Hamid, Yuanyuan Xu, Mohamed Ameen Ismahil, Qianhong Li, Steven P Jones, Aruni Bhatnagar, Roberto Bolli, Sumanth D Prabhu
Despite expansion of resident cardiac stem cells (CSCs; c-kit(+)Lin(-)) after myocardial infarction, endogenous repair processes are insufficient to prevent adverse cardiac remodeling and heart failure (HF). This suggests that the microenvironment in post-ischemic and failing hearts compromises CSC regenerative potential. Inflammatory cytokines, such as tumor necrosis factor-α (TNF), are increased after infarction and in HF; whether they modulate CSC function is unknown. As the effects of TNF are specific to its two receptors (TNFRs), we tested the hypothesis that TNF differentially modulates CSC function in a TNFR-specific manner...
November 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27548259/cardiomyocyte-specific-ablation-of-med1-subunit-of-the-mediator-complex-causes-lethal-dilated-cardiomyopathy-in-mice
#15
Yuzhi Jia, Hsiang-Chun Chang, Matthew J Schipma, Jing Liu, Varsha Shete, Ning Liu, Tatsuya Sato, Edward B Thorp, Philip M Barger, Yi-Jun Zhu, Navin Viswakarma, Yashpal S Kanwar, Hossein Ardehali, Bayar Thimmapaya, Janardan K Reddy
Mediator, an evolutionarily conserved multi-protein complex consisting of about 30 subunits, is a key component of the polymerase II mediated gene transcription. Germline deletion of the Mediator subunit 1 (Med1) of the Mediator in mice results in mid-gestational embryonic lethality with developmental impairment of multiple organs including heart. Here we show that cardiomyocyte-specific deletion of Med1 in mice (csMed1-/-) during late gestational and early postnatal development by intercrossing Med1fl/fl mice to α-MyHC-Cre transgenic mice results in lethality within 10 days after weaning due to dilated cardiomyopathy-related ventricular dilation and heart failure...
2016: PloS One
https://www.readbyqxmd.com/read/27498024/myocardial-plasticity-cardiac-development-regeneration-and-disease
#16
REVIEW
Joshua Bloomekatz, Manuel Galvez-Santisteban, Neil C Chi
The adult mammalian heart is unable to recover from myocardial cell loss due to cardiac ischemia and infarction because terminally differentiated cardiomyocytes proliferate at a low rate. However, cardiomyocytes in other vertebrate animal models such as zebrafish, axolotls, newts and mammalian mouse neonates are capable of de-differentiating in order to promote cardiomyocyte proliferation and subsequent cardiac regeneration after injury. Although de-differentiation may occur in adult mammalian cardiomyocytes, it is typically associated with diseased hearts and pathologic remodeling rather than repair and regeneration...
October 2016: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/27484198/innate-heart-regeneration-endogenous-cellular-sources-and-exogenous-therapeutic-amplification
#17
Konstantinos Malliaras, Styliani Vakrou, Chris J Kapelios, John N Nanas
INTRODUCTION: The -once viewed as heretical- concept of the adult mammalian heart as a dynamic organ capable of endogenous regeneration has recently gained traction. However, estimated rates of myocyte turnover vary wildly and the underlying mechanisms of cardiac plasticity remain controversial. It is still unclear whether the adult mammalian heart gives birth to new myocytes through proliferation of resident myocytes, through cardiomyogenic differentiation of endogenous progenitors or through both mechanisms...
November 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27472922/bmi1-cardiac-progenitor-cells-contribute-to-myocardial-repair-following-acute-injury
#18
Iñigo Valiente-Alandi, Carmen Albo-Castellanos, Diego Herrero, Iria Sanchez, Antonio Bernad
BACKGROUND: The inability of the adult mammalian heart to replace cells lost after severe cardiac injury compromises organ function. Although the heart is one of the least regenerative organs in the body, evidence accumulated in recent decades indicates a certain degree of renewal after injury. We have evaluated the role of cardiac Bmi1 (+) progenitor cells (Bmi1-CPC) following acute myocardial infarction (AMI). METHODS: Bmi1 (Cre/+);Rosa26 (YFP/+) (Bmi1-YFP) mice were used for lineage tracing strategy...
2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27471727/discovering-mirna-regulatory-networks-in-holt-oram-syndrome-using-a-zebrafish-model
#19
Romina D'Aurizio, Francesco Russo, Elena Chiavacci, Mario Baumgart, Marco Groth, Mara D'Onofrio, Ivan Arisi, Giuseppe Rainaldi, Letizia Pitto, Marco Pellegrini
MicroRNAs (miRNAs) are small non-coding RNAs that play an important role in the post-transcriptional regulation of gene expression. miRNAs are involved in the regulation of many biological processes such as differentiation, apoptosis, and cell proliferation. miRNAs are expressed in embryonic, postnatal, and adult hearts, and they have a key role in the regulation of gene expression during cardiovascular development and disease. Aberrant expression of miRNAs is associated with abnormal cardiac cell differentiation and dysfunction...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27424216/three-dimensional-scaffolds-of-fetal-decellularized-hearts-exhibit-enhanced-potential-to-support-cardiac-cells-in-comparison-to-the-adult
#20
A C Silva, S C Rodrigues, J Caldeira, A M Nunes, V Sampaio-Pinto, T P Resende, M J Oliveira, M A Barbosa, S Thorsteinsdóttir, D S Nascimento, P Pinto-do-Ó
A main challenge in cardiac tissue engineering is the limited data on microenvironmental cues that sustain survival, proliferation and functional proficiency of cardiac cells. The aim of our study was to evaluate the potential of fetal (E18) and adult myocardial extracellular matrix (ECM) to support cardiac cells. Acellular three-dimensional (3D) bioscaffolds were obtained by parallel decellularization of fetal- and adult-heart explants thereby ensuring reliable comparison. Acellular scaffolds retained main constituents of the cardiac ECM including distinctive biochemical and structural meshwork features of the native equivalents...
October 2016: Biomaterials
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