Monireh Saeid Nia, Lena Maria Floder, Jette Anika Seiler, Thomas Puehler, Nina Sophie Pommert, Rouven Berndt, David Meier, Stephanie L Sellers, Janarthanan Sathananthan, Xiling Zhang, Mario Hasler, Stanislav N Gorb, Gregor Warnecke, Georg Lutter
One of the most important medical interventions for individuals with heart valvular disease is heart valve replacement, which is not without substantial challenges, particularly for pediatric patients. Due to their biological properties and biocompatibility, natural tissue-originated scaffolds derived from human or animal sources are one type of scaffold that is widely used in tissue engineering. However, they are known for their high potential for immunogenicity. Being free of cells and genetic material, decellularized xenografts, consequently, have low immunogenicity and, thus, are expected to be tolerated by the recipient's immune system...
April 4, 2024: International Journal of Molecular Sciences