Rolf Gräbner, Katharina Lötzer, Sandra Döpping, Markus Hildner, Dörte Radke, Michael Beer, Rainer Spanbroek, Beatrix Lippert, Catherine A Reardon, Godfrey S Getz, Yang-Xin Fu, Thomas Hehlgans, Reina E Mebius, Michael van der Wall, Dagmar Kruspe, Christoph Englert, Agnes Lovas, Desheng Hu, Gwendalyn J Randolph, Falk Weih, Andreas J R Habenicht
Atherosclerosis involves a macrophage-rich inflammation in the aortic intima. It is increasingly recognized that this intimal inflammation is paralleled over time by a distinct inflammatory reaction in adjacent adventitia. Though cross talk between the coordinated inflammatory foci in the intima and the adventitia seems implicit, the mechanism(s) underlying their communication is unclear. Here, using detailed imaging analysis, microarray analyses, laser-capture microdissection, adoptive lymphocyte transfers, and functional blocking studies, we undertook to identify this mechanism...
January 16, 2009: Journal of Experimental Medicine