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https://www.readbyqxmd.com/read/29028632/procalcitonin-as-a-diagnostic-and-prognostic-marker-in-diabetic-foot-infection-a-current-literature-review
#1
Dimitrios Velissaris, Nikolaos-Dimitrios Pantzaris, Christina Platanaki, Nikolina Antonopoulou, Charalampos Gogos
Diabetic foot ulcers (DFUs) are a very common cause of mortality and morbidity. The distinction between infected and non-infected DFU remains a very challenging task for clinicians in everyday practice. Even when infection is documented, the spectrum of diabetic foot infection is wide, ranging from cellulitis and soft tissue infection to osteomyelitis. Procalcitonin (PCT), a well-established sepsis biomarker, has been used in the diagnosis of several infections including osteomyelitis in patients with diabetes mellitus...
October 11, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29026467/chromogranin-a-as-a-biochemical-marker-for-neuroendocrine-tumors-a-single-center-experience-at-royal-hospital-oman
#2
Elham S Al-Risi, Fatma S Al-Essry, Waad-Allah S Mula-Abed
OBJECTIVES: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman. METHODS: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014)...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29023974/diabetes-related-major-lower-limb-amputation-incidence-is-strongly-related-to-diabetic-foot-service-provision-and-improves-with-enhancement-of-services-peer-review-of-the-south-west-of-england
#3
R B Paisey, A Abbott, R Levenson, A Harrington, D Browne, J Moore, M Bamford, M Roe
AIMS: To investigate the relationship between high diabetes-related lower limb amputation incidence and foot care services in the South-West region of England. METHODS: The introduction of 10 key elements of foot care service provision in one area of the South-West resulted in stabilization of foot ulcer incidence and sustained reduction in amputation incidence from 2007. Services introduced included administrative support, standardized general practice foot screening, improved community podiatry staffing, hospital multidisciplinary foot clinics, effective care pathways, availability of an orthotist and audit...
October 11, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29023192/a-study-on-the-macroscopic-morphometry-of-the-lesion-area-on-diabetic-ulcers-in-humans-treated-with-photodynamic-therapy-using-two-methods-of-measurement
#4
Patrícia Michelassi Carrinho, Dora Inés Kozusny Andreani, Vislaine de Aguiar Morete, Shizumi Iseri, Ricardo Scarparo Navarro, Antonio Balbin Villaverde
INTRODUCTION: Diabetes Mellitus is a chronic disease that can lead to lower-limb ulceration. The photodynamic therapy (PDT) is based on light interaction with a photosensitizer capable to promote bacterial death and acceleration of wound healing. This study aims to accomplish a macroscopic morphometry evaluation on diabetic ulcer area in humans that were under PDT. MATERIALS AND METHODS: A clinical study was conducted by convenience sample, experimental, controlled, and blinded, composed of 12 patients of both sexes with diabetic ulcers in lower limbs that were divided into two groups, control (n = 6) and PDT (n = 6)...
October 9, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29017807/unplanned-30-day-readmission-in-patients-with-diabetic-foot-wounds-treated-in-a-multidisciplinary-setting
#5
Courtenay M Holscher, Caitlin W Hicks, Joseph K Canner, Ronald L Sherman, Mahmoud B Malas, James H Black, Nestoras Mathioudakis, Christopher J Abularrage
OBJECTIVE: Readmission rates are known to be high for vascular surgery patients in general, but there are limited data describing the risk of surgical and nonsurgical readmission among patients with diabetic foot ulcers (DFUs). Our aim was to identify factors associated with unplanned readmission in DFU patients treated in a multidisciplinary setting. METHODS: We studied a single-center cohort of patients enrolled in a multidisciplinary diabetic foot service (July 2012-June 2017)...
October 7, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29017535/the-leucopatch%C3%A2-system-in-the-management-of-hard-to-heal-diabetic-foot-ulcers-study-protocol-for-a-randomised-controlled-trial
#6
Frances Game, William Jeffcoate, Lise Tarnow, Florence Day, Deborah Fitzsimmons, Judith Jacobsen
BACKGROUND: Diabetic foot ulcers are a common and severe complication of diabetes mellitus. Standard treatment includes debridement, offloading, management of infection and revascularisation where appropriate, although healing times may be long. The LeucoPatch® device is used to generate an autologous platelet-rich fibrin and leucocyte wound dressing produced from the patient's own venous blood by centrifugation, but without the addition of any reagents. The final product comprises a thin, circular patch composed predominantly of fibrin together with living platelets and leucocytes...
October 10, 2017: Trials
https://www.readbyqxmd.com/read/28992159/compliance-with-accreditation-and-recommended-hospital-care-a-danish-nationwide-population-based-study
#7
Anne Mette Falstie-Jensen, Søren Bie Bogh, Erik Hollnagel, Søren Paaske Johnsen
Objective: To examine the association between compliance with accreditation and recommended hospital care. Design: A Danish nationwide population-based follow-up study based on data from six national, clinical quality registries between November 2009 and December 2012. Setting: Public, non-psychiatric Danish hospitals. Participants: Patients with acute stroke, chronic obstructive pulmonary disease, diabetes, heart failure, hip fracture and bleeding/perforated ulcers...
October 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28991769/let-s-go-bananas-gren-bananas-and-their-health-benefits
#8
Vasso Apostolopoulos, Juliana Antonipillai, Kathy Tangalakis, John F Ashton, Lily Stojanovska
Bananas have enormous health benefits as a food for both animals and humans. They have been used as a complimentary medicine to treat pathological conditions since ancient times. Recently, there has been increased interest in the scientific validity of the beneficial effects of bananas in alleviating and treating disease conditions including, ulcers, infections, diabetes, diarrhea, colitis and blood pressure. Herein, we write on the potential therapeutic and functional benefits of certain species of bananas when consumed green as well as considering the properties of extracts from the non-fruit parts of the plant...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28990362/an-explorative-study-on-the-validity-of-various-definitions-of-a-2%C3%A2-2%C3%A2-c-temperature-threshold-as-warning-signal-for-impending-diabetic-foot-ulceration
#9
Anke M Wijlens, Samantha Holloway, Sicco A Bus, Jaap J van Netten
Home monitoring of skin temperature is effective to prevent diabetic foot ulceration. We explored the validity of various definitions for the >2·2°C left-to-right threshold used as a warning signal for impending ulceration. Twenty patients with diabetes and peripheral neuropathy monitored their skin temperature with an infrared thermometer at the plantar hallux, metatarsal heads, midfoot and heel four times a day for 6 consecutive days. Environmental temperature and walking activity were monitored and associated with foot temperature...
October 9, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28989875/bacteriological-profile-of-diabetic-foot-ulcer-with-special-reference-to-drug-resistant-strains-in-a-tertiary-care-center-in-north-east-india
#10
Sudhir K Jain, Rashmisnata Barman
AIM: This study was carried out to determine the bacteriological profile of infected diabetic foot ulcers (DFUs) and the antibiotic resistance pattern from the isolates. An attempt was made to suggest an empiric antibiotic regimen to treat such patients. MATERIALS AND METHODS: Tissue samples were collected from 150 patients between February 2015 and January 2016 with DFUs under aseptic precautions and they were processed as per the Clinical and Laboratory Standards Institute guidelines...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28989569/clinical-profile-of-diabetes-at-diagnosis-among-children-and-adolescents-at-an-endocrine-clinic-in-ghana
#11
Emmanuel Ameyaw, Serwah B Asafo-Agyei, Sumithira Thavapalan, Angela C Middlehurst, Graham D Ogle
AIM: To determine the clinical features of diabetes in children and adolescents in Ghana. METHODS: Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016. RESULTS: One hundred and six subjects presented with diabetes. Ninety (84.9%) were diagnosed by clinical features and family history as type 1, and 16 (15...
September 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28989556/fibreglass-total-contact-casting-removable-cast-walkers-and-irremovable-cast-walkers-to-treat-diabetic-neuropathic-foot-ulcers-a-health-technology-assessment
#12
(no author information available yet)
BACKGROUND: Diabetic neuropathic foot ulcers are a risk factor for lower leg amputation. Many experts recommend offloading with fibreglass total contact casting, removable cast walkers, and irremovable cast walkers as a way to treat these ulcers. METHODS: We completed a health technology assessment, which included an evaluation of clinical benefits and harms, value for money, and patient preferences for offloading devices. We performed a systematic literature search on August 17, 2016, to identify randomized controlled trials that compared fibreglass total contact casting, removable cast walkers, and irremovable cast walkers with other treatments (offloading or non-offloading) in patients with diabetic neuropathic foot ulcers...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28987067/reconstruction-of-severe-atherosclerotic-and-obstructive-diabetic-feet-using-thoracodorsal-artery-perforator-flaps-with-long-vascular-pedicles
#13
Sang Wha Kim, Il Hoon Sung, Youn Hwan Kim
BACKGROUND: Foot ulcers in diabetic patients often require free flaps. A long vascular pedicle is mandatory so that more proximal vessels can be used as recipient vessels, especially when the flap is used to reconstruct distal foot defects. We evaluated the outcome of diabetic foot defect that were reconstructed using thoracodorsal artery perforator (TDAP) flaps with long vascular pedicles. PATIENTS AND METHODS: We reconstructed the foot defects of 22 diabetic patients...
October 7, 2017: Microsurgery
https://www.readbyqxmd.com/read/28987032/functionalized-pva-silk-blended-nanofibrous-mats-promote-diabetic-wound-healing-via-regulation-of-extracellular-matrix-and-tissue-remodeling
#14
Dimple Chouhan, G Janani, Bijayashree Chakraborty, Samit K Nandi, Biman B Mandal
Chronic cutaneous ulcers, a complex pathophysiological diabetic condition, represent a critical clinical challenge in the current diabetes mellitus pandemic. Consequently, there is a compelling need for bioactive dressings which can trigger healing processes for complete wound repair. Silk fibroin (SF), a natural protein polymer from mulberry and non-mulberry silkworms, has properties that support accelerated wound healing rate. SF from non-mulberry variety possesses additional cell-binding motifs (RGD), offering cell-material interactions...
October 7, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28985487/lower-extremity-dynamics-of-walking-in-neuropathic-diabetic-patients-who-wear-a-forefoot-offloading-shoe
#15
Sicco A Bus, Josina C Maas, Nicoline M Otterman
BACKGROUND: A forefoot-offloading shoes has a negative-heel rocker outsole and is used to treat diabetic plantar forefoot ulcers, but its mechanisms of action and their association with offloading and gait stability are not sufficiently clear. METHODS: Ten neuropathic diabetic patients were tested in a forefoot-offloading shoe and subsequently in a control shoe with no specific offloading construction, both worn on the right foot (control shoe on left), while walking at 1...
October 2, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28983285/microbiota-of-chronic-diabetic-wounds-ecology-impact-and-potential-for-innovative-treatment-strategies
#16
REVIEW
Sónia G Pereira, João Moura, Eugénia Carvalho, Nuno Empadinhas
World Health Organization considered diabetes as one of the 20th century epidemics, estimating that over 10% of the world population is diabetic or at high risk. Self-assessment studies indicate that diabetic patients consider chronic wounds to affect their quality of life more dramatically than vision loss or renal failure. In addition to being the main reason for diabetic patients' hospitalization, the economic burden of diabetic chronic wounds is close to 1% of United Kingdom and United States health systems budgets, which exceeds the funds allocated to the treatment of some types of cancer in both countries...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28980181/outcome-of-intra-arterial-thrombolysis-in-patients-with-diabetes-and-acute-lower-limb-ischemia-a-propensity-score-adjusted-analysis
#17
Talha Butt, Anders Gottsäter, Jan Apelqvist, Gunnar Engström, Stefan Acosta
The presence of diabetes mellitus is rarely addressed in acute lower limb ischaemia (ALLI). The aim of this study was to evaluate the outcome of local intra-arterial thrombolysis for ALLI in patients with diabetes mellitus (DM). Outcome of all thrombolytic events performed in an endovascular first-strategy centre during a 13-year period between 2001 and 2013 in patients with ALLI were followed to January 2017. A propensity score adjusted analysis was performed to evaluate results in patients with (n = 83) versus without (n = 316) DM...
October 4, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28979615/-podiatric-risk-screening-in-patients-with-type-2-diabetes-in-antananarivo
#18
Sitraka Angelo Raharinavalona, Haritsiky Robertini Ramalanjaona, Nalisoa Andrianera, Andrinirina Dave Patrick Rakotomalala, George Ramahandridona
Diabetic foot disease heavily weighs upon diabetics, being a significant cause of morbidity and severe disability. Their prevention is indispensable. Our study aimed to reduce the rate of amputations in diabetics. We conducted a retrospective, descriptive, cross-sectional, multicenter study of podiatric risk screening in patients with type 2 diabetes in the Endocrinology Department at the University Hospital of Befelatanana and at the Amadia Clinic, Faravohitra, over a period of 6 months. The average age of our patients was 54...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28977630/the-limited-cutaneous-form-of-systemic-sclerosis-is-associated-with-urinary-incontinence-an-international-multicentre-study
#19
Gregor John, Yannick Allanore, Pamela Polito, Silvia Piantoni, Micaela Fredi, Jérôme Avouac, Franco Franceschini, Marie-Elise Truchetet, Franco Cozzi, Paolo Airo, Carlo Chizzolini
Objectives: The aim of this study was to explore the association between urinary incontinence (UI) and the main clinical and serological subsets of SSc, to assess risk factors for UI and its impact on quality of life (QoL). Methods: UI and QoL were assessed through self-administered questionnaires in 334 patients with SSc from five European tertiary centres. Logistic regressions were performed to test the association between clinical forms, serological status and UI and to adjust for confounders...
August 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28976835/use-of-cryopreserved-umbilical-cord-with-negative-pressure-wound-therapy-for-complex-diabetic-ulcers-with-osteomyelitis
#20
A Raphael, J Gonzales
OBJECTIVE: The objective of this study was to evaluate the combined use of cryopreserved human umbilical cord (cUC) allograft and negative pressure wound therapy (NPWT) in treating complex diabetic foot ulcers (DFUs) with bone exposure and osteomyelitis. These types of wound are known to carry a high morbidity and mortality. METHODS: A single-center, retrospective chart review was performed to assess the efficacy of the combined use of cUC with NPWT, by the same surgeon, to help promote the closure of complex DFUs presenting with biopsy-proven osteomyelitis...
October 1, 2017: Journal of Wound Care
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