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https://www.readbyqxmd.com/read/28640170/effectiveness-of-electroconvulsive-therapy-and-associated-cognitive-change-in-schizophrenia-a-naturalistic-comparative-study-of-treating-schizophrenia-with-electroconvulsive-therapy
#1
Phern-Chern Tor, Jiangbo Ying, New Fei Ho, Mingyuan Wang, Donel Martin, Chai Pin Ang, Chunzhen Tan, Lee Shen Yap, Vincent John Magat Lu, Brett Simpson, Yee Ming Mok, Colleen Loo
OBJECTIVE: There is limited evidence regarding the relative treatment effectiveness and cognitive effects of different types of electroconvulsive therapy (ECT) in schizophrenia. In this study, we sought to determine the overall effectiveness and compare the symptomatic and cognitive outcomes of patients with schizophrenia who received different modalities of ECT treatment. METHODS: Patients received 1 of 4 of the following ECT modalities: bitemporal ECT with age-based dosing, right unilateral ECT with seizure threshold-based dosing, bitemporal ECT with seizure threshold-based dosing, and bifrontal ECT with seizure threshold-based dosing ECT...
June 15, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28639714/plasma-cytokine-il-6-levels-and-subjective-cognitive-decline-preliminary-findings
#2
Andrew P Keegan, Daniel Paris, Cheryl A Luis, Laila Abdullah, Ghania Ait-Ghezala, David Beaulieu-Abdelahad, Makenzie Pryor, Jillian Chaykin, Gogce Crynen, Fiona Crawford, Michael Mullan
OBJECTIVE: Detection of Alzheimer's disease (AD) prior to clinical inception will be paramount for introducing disease modifying treatments. We have begun collecting baseline characteristics of a community cohort for longitudinal assessment and testing of antecedent blood-based biomarkers. We describe the baseline visit from the first 131 subjects in relationship to a commonly described cytokine, interleukin 6 (IL-6). METHODS: Subjects from the community presented for a free memory screening with varying degrees of memory concern...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28638717/validation-of-the-parkinson-fatigue-scale-in-chinese-parkinson-s-disease-patients
#3
Rao Fu, Shi-Shuang Cui, Juan-Juan Du, Pei Huang, Ya-Chao He, Chao Gao, Xiao-Guang Luo, Sheng-Di Chen
OBJECTIVE: Fatigue is a common nonmotor symptom in Parkinson's disease (PD); however, the Parkinson's disease fatigue scale (PFS), which is designed to measure fatigue in PD, has not been validated in China. The aim of this study was to determine the validity and reliability of the Chinese version of the PFS in PD patients. METHODS: A total of 115 PD patients were evaluated at baseline and after 7 days. Assessments included the PFS, the Fatigue Severity Scale (FSS), and scales assessing motor, cognition, depression, and anxiety...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28638609/cognitive-function-and-advanced-kidney-disease-longitudinal-trends-and-impact-on-decision-making
#4
Osasuyi Iyasere, David Okai, Edwina Brown
Background: Cognitive impairment commonly affects renal patients. But little is known about the influence of dialysis modality on cognitive trends or the influence of cognitive impairment on decision-making in renal patients. This study evaluated cognitive trends amongst chronic kidney disease (CKD), haemodialysis (HD) and peritoneal dialysis (PD) patients. The relationship between cognitive impairment and decision-making capacity (DMC) was also assessed. Methods: Patients were recruited from three outpatient clinics...
February 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28594795/-assessing-efficacy-of-carotid-endarterectomy-by-means-of-intraoperative-flowmetry
#5
V A Luk'ianchikov, A S Tokarev, N A Polunina, O Iu Nakhabin, E V Udodov, V A Dalibaldian, A V Sytnik, V V Krylov
AIM: The study was aimed at determining volumetric blood flow velocity (VBFV) through the internal carotid artery (ICA) and assessing functional outcomes of treatment of patients, taking into consideration the dynamics of VBFV before and after the operation. PATIENTS AND METHODS: The study comprised a total of 53 patients subjected to examination of VBFV through the ICA before and after carotid endarterectomy (CEA) assessed by means of flowmetry. Neurological deficit was evaluated by means of the NIHS Scale (the M NIHSS prior to operation equalling 2...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28592382/incidence-of-mri-detected-brain-lesions-and-neurocognitive-function-after-electrical-cardioversion-in-anticoagulated-patients-with-persistent-atrial-fibrillation
#6
B Bellmann, J B Fiebach, S Guttmann, T Lin, K G Haeusler, R Bathe-Peters, L Köhler, D Steffens, M Kasner, V Tscholl, P Nagel, M Roser, U Landmesser, A Rillig
BACKGROUND: After electrical cardioversion (eCV) in patients with atrial fibrillation (AF), the risk for clinically apparent cerebral thromboembolism is increased in the subsequent weeks. To date, there is little evidence on the incidence of acute brain lesions (ABL) detected with cerebral magnetic resonance imaging (MRI) after eCV, in particular in patients treated with the Non-Vitamin K Antagonist oral anticoagulants (NOAC). AIMS: The aim of this pilot study was to evaluate the incidence of MRI-detected ABL, as well as the neuro-cognitive function after eCV in patients with persistent AF using NOACs as compared to phenprocoumon...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28589163/a-novel-design-of-a-phase-iii-trial-of-isradipine-in-early-parkinson-disease-steady-pd-iii
#7
Kevin M Biglan, David Oakes, Anthony E Lang, Robert A Hauser, Karen Hodgeman, Brittany Greco, Jillian Lowell, Rebecca Rockhill, Ira Shoulson, Charles Venuto, Diony Young, Tanya Simuni
OBJECTIVE: To describe the rationale for a novel study design and baseline characteristics of a disease-modifying trial of isradipine 10 mg daily in early Parkinson disease (PD). METHODS: STEADY-PDIII is a 36-month, Phase 3, parallel group, placebo-controlled study of the efficacy of isradipine 10 mg daily in 336 participants with early PD as measured by the change in the Unified Parkinson Disease Rating Scale (UPDRS) Part I-III score in the practically defined ON state...
June 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28584406/the-relationship-between-psychosocial-factors-and-cognition-in-multiple-sclerosis
#8
Fahad D Alosaimi, Alaa AlMulhem, Mario Moscovici, Hanan AlShalan, Mohammad Alqazlan, Abdulgader Aldaif, Sanjeev Sockalingam
INTRODUCTION: Multiple sclerosis (MS) is a common disorder in some regions of the world, with over 2.3 million people diagnosed worldwide. Cognitive impairment is one of the earliest symptoms to present in the course of the disease and can cause significant morbidity. We proposed a study to explore the psychosocial predictors of cognitive impairment in MS patients in Saudi Arabia, a previously unexplored patient population. METHODS: Demographic data, depression scale (PHQ9), symptom burden (PHQ15), anxiety (GAD7), disease duration, and Montreal Cognitive Assessment (MOCA) scores were collected from 195 patients in a neurology clinic in Ryiadh, Saudi Arabia...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28572768/gait-change-is-associated-with-cognitive-outcome-after-an-acute-ischemic-stroke
#9
Sharmila Sagnier, Pauline Renou, Stéphane Olindo, Sabrina Debruxelles, Mathilde Poli, François Rouanet, Fanny Munsch, Thomas Tourdias, Igor Sibon
Background: Cognition and gait have often been studied separately after stroke whereas it has been suggested that these two domains could interact through a cognitive-motor interference. Objective: To evaluate the influence of gait changes on cognitive outcome after an ischemic stroke (IS). Methods: We conducted a prospective and monocentric study including patients admitted for an acute supratentorial IS with a National Institute of Health Stroke Score ≤ 15. Cognition, gait and motor disability were evaluated at baseline, 3 months and 1 year post-stroke, using the Montreal Cognitive Assessment (MoCA), the 10-m walking test (10-MWT) and the Fugl-Meyer motor assessment (FMMA)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28572020/factor-structure-of-the-montreal-cognitive-assessment-items-in-a-sample-with-early-parkinson-s-disease
#10
Jared F Benge, Steve Balsis, Taronish Madeka, Claire Uhlman, Crystal Lantrip, Michael J Soileau
INTRODUCTION: The Montreal Cognitive Assessment (MoCA) is a frequently utilized cognitive screening tool that has attractive clinical attributes when utilized in individuals with Parkinson's disease. However, the construct validity of this instrument has not been well-characterized in Parkinson's samples. The purpose of this study is to explore the underlying factor structure of the MoCA in individuals with early stage Parkinson's disease. METHOD: Item responses from the MoCA in 357 individuals with Parkinson's disease from the Parkinson's Progression Markers Initiative were analyzed first for frequency of errors and polychoric inter item correlations...
May 25, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28565786/expression-of-s100%C3%AE-protein-in-patients-with-vascular-dementia-after-basal-ganglia-hemorrhage-and-its-clinical-significance
#11
Shuaitao Shi, Guoquan Wang, Kewei Zhang, Zhidong Zhang, Kai Liang, Kun Li, Weixiao Li, Shuiting Zhai
We investigated the expression levels and clinical significance of S100β protein in patients with vascular dementia (VD) after basal ganglia hemorrhage. From June 2014 to December 2015, in 138 patients with basal ganglia hemorrhage, we carried out the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in patients on the day before the operation, the day after the operation and 9 days after the operation. Thirty-two patients (blood vessel group) had cognitive dysfunction and 106 patients (control group) had VD...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28550262/increased-plasma-homocysteine-level-is%C3%A2-associated-with-executive-dysfunction-in%C3%A2-type-2-diabetic-patients-with-mild-cognitive-impairment
#12
Sai Tian, Jing Han, Rong Huang, Jie Sun, Rongrong Cai, Yanjue Shen, Shaohua Wang
BACKGROUND: Homocysteine (Hcy) is involved in the pathogenesis of type 2 diabetes mellitus (T2DM) and Alzheimer's disease. OBJECTIVE: We aimed to investigate the role of Hcy in T2DM patients with mild cognitive impairment (MCI), and to determine whether methylene tetrahydrofolate reductase (MTHFR) C677T or cystathionine beta-synthase (CBS) 844ins68 polymorphism is related to T2DM-associated MCI. METHODS: We recruited 285 T2DM patients and divided them into two groups, 140 patients with MCI, and 145 healthy-cognition controls, on the basis of Montreal Cognitive Assessment (MoCA) scores...
May 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28548298/total-cerebral-small-vessel-disease-score-and-cognitive-performance-in-community-dwelling-older-adults-results-from-the-atahualpa-project
#13
Victor J Del Brutto, Jorge G Ortiz, Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, José Biller
OBJECTIVE: Cerebral small vessel disease (SVD) is inversely associated with cognitive performance. However, whether the total SVD score is a better predictor of poor cognitive performance than individual signatures of SVD is inconclusive. We aimed to estimate the combined and independent predictive power of these MRI findings. METHODS: Atahualpa residents aged ≥60 years underwent brain MRI. Cognitive performance was measured by the Montreal Cognitive Assessment (MoCA)...
May 26, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28538520/radiation-induced-cerebellar-cerebral-functional-connectivity-alterations-in-nasopharyngeal-carcinoma-patients
#14
Qiongmin Ma, Ling-Li Zeng, Jian Qin, Zhiguo Luo, Jianpo Su, Donglin Wu, Shijun Qiu, Dewen Hu
The current study aimed to investigate the altered cerebellar-cerebral functional connectivity (FC) induced by radiotherapy to nasopharyngeal carcinoma (NPC) patients. Twenty-four NPC patients without treatment, and 35 NPC patients receiving radiotherapy underwent functional MRI scanning. Montreal cognitive assessment (MoCA) was performed to evaluate the cognitive status of all participants. FC between 10 predefined cerebellar seeds, which were demonstrated to be involved in different brain functional networks, and all brain voxels was obtained for each participant...
May 19, 2017: Neuroreport
https://www.readbyqxmd.com/read/28528240/negative-correlation-between-csf-lactate-levels-and-moca-scores-in-male-chinese-subjects
#15
Haijun Wang, Xiaohua Tan, Jinzhong Xu, Hui Li, Meiling Wang, Suling Chen, Xiaoyu Yang, Yanlong Liu, Fan Wang
Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal condition. In the present study, concentrations of lactate in cerebrospinal fluid (CSF) and peripheral blood were measured to investigate the association of lactate with cognitive ability, which was assessed by Montreal Cognitive Assessment (MoCA), in 99 male Chinese subjects...
May 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28520873/association-between-neurocognitive-decline-and-visual-field-variability-in-glaucoma
#16
Alberto Diniz-Filho, Lisa Delano-Wood, Fábio B Daga, Sebastião Cronemberger, Felipe A Medeiros
Importance: Visual field variability may impair detection of glaucoma progression over time. Despite the possible overlap between neurocognitive disorders and glaucoma in older individuals, no study has investigated the association between cognitive changes and visual field variability. Objective: To evaluate the association between global neurocognitive impairment and visual field variability in patients diagnosed as having glaucoma or glaucoma suspects. Design, Setting, and Participants: This prospective observational cohort study was conducted at the Visual Performance Laboratory, University of California, San Diego...
May 18, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28514669/the-relationship-between-cognition-and-depressive-symptoms-and-factors-modifying-this-association-in-alzheimer-s-disease-a-multivariate-multilevel-model
#17
Bei Yang, Hongmei Yu, Min Xing, Runlian He, Ruifeng Liang, Liye Zhou
OBJECTIVES: To examine whether there was a bidirectional association between cognition and depressive symptoms in Alzheimer's disease (AD), and to explore the role of socio-demographic factors and daily performance in this association. METHODS: We conducted a longitudinal study of 104 community-dwelling patients with confirmed AD from Taiyuan, China. We assessed cognition and depressive symptoms (dependent variables) with the Montreal Cognitive Assessment (MoCA) and the Geriatric Depression Scale-30 (GDS-30), respectively...
May 10, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28511984/comparison-of-three-cognitive-exams-in-cardiac-arrest-survivors
#18
Allison C Koller, Jon C Rittenberger, Melissa J Repine, Patrick W Morgan, Jeffrey Kristan, Clifton W Callaway
BACKGROUND: Cognitive deficits may detract from quality of life after cardiac arrest. Their pattern and prevalence are not well documented. We used the Computer Assessment of Mild Cognitive Impairment (CAMCI), the Montreal Cognitive Assessment (MOCA) and the 41 Cent Test (41CT) to assess cognitive impairment in cardiac arrest survivors and examine the exams' diagnostic accuracy. We hypothesized that the scores of these exams would indicate the presence of cognitive impairment in arrest survivors, that the overall scores on the three study assessments would correlate with one another, and that the 41CT, MOCA, and executive function element of the CAMCI would vary independently from other non-executive CAMCI components, reflecting executive function impairment after cardiac arrest...
July 2017: Resuscitation
https://www.readbyqxmd.com/read/28499360/prevalence-and-correlates-of-cognitive-impairment-in-kidney-transplant-recipients
#19
Aditi Gupta, Jonathan D Mahnken, David K Johnson, Tashra S Thomas, Dipti Subramaniam, Tyler Polshak, Imran Gani, G John Chen, Jeffrey M Burns, Mark J Sarnak
BACKGROUND: There is a high prevalence of cognitive impairment in dialysis patients. The prevalence of cognitive impairment after kidney transplantation is unknown. METHODS: Study Design: Cross-sectional study. SETTING AND PARTICIPANTS: Single center study of prevalent kidney transplant recipients from a transplant clinic in a large academic center. INTERVENTION: Assessment of cognition using the Montreal Cognitive Assessment (MoCA)...
May 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28489814/diagnostic-values-of-serum-levels-of-homocysteine-and-uric-acid-for-predicting-vascular-mild-cognitive-impairment-in-patients-with-cerebral-small-vessel-disease
#20
Ting Wang, Zhong-Wu Sun, Liang-Qing Shao, Xiao-Bin Xu, Yang Liu, Mao Qin, Xiang Weng, Yong-Xiang Zhang
BACKGROUND This study aimed to investigate the diagnostic values of serum levels of Hcy and UA for predicting vascular mild cognitive impairment (VMCI) in patients with cerebral small vessel disease (SVD). MATERIAL AND METHODS We selected 172 cerebral SVD patients and divided them into a VMCI group and a non-VMCI group. Eighty-six healthy individuals without nervous system diseases were selected as the control group. Enzymatic cycling method was performed to detect serum Hcy and UA levels. Serum levels of folic acid (FOA) and vitamin B12 (VitB12) were detected by chemiluminescence immunoassay...
May 10, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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