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https://www.readbyqxmd.com/read/29350337/baseline-neurocognitive-functioning-predicts-viral-load-suppression-at-1-year-follow-up-among-newly-diagnosed-hiv-infected-patients
#1
Lokesh Shahani, Lucrecia Salazar, Steven P Woods, Rodrigo Hasbun
The current prospective observational study evaluated the impact of baseline neurocognitive impairment on future viral load suppression among antiretroviral medication naive persons newly diagnosed with HIV infection. We used the Montreal Cognitive Assessment (MoCA) score less than 26, to identify patients with neurocognitive deficits. Of the 138 patients enrolled; virologic suppression was seen in 61% of the participants, while 72% of the participants had a MoCA score less than 26 at baseline. Variables significantly associated with low MoCA score included higher age (p < 0...
January 19, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29344357/examining-the-effectiveness-of-a-cognitive-intervention-to-improve-cognitive-function-in-a-population-of-older-adults-living-with-hiv-a-pilot-study
#2
Judy A Frain, Ling Chen
Objective: The purpose of this randomized-controlled pilot study was to explore the effectiveness of a home-based computerized cognitive training intervention in improving cognitive function in a population of older adults with mild cognitive impairment who are living with HIV. Methods: In all, 24 participants were enrolled in this study. All study participants were impaired [defined as Montreal Cognitive Assessment (MoCA) score < 26]; 12 were randomly assigned to a computer-training intervention group and 12 to a control group...
January 2018: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/29343241/clinical-features-and-dysfunctions-of-iron-metabolism-in-parkinson-disease-patients-with-hyper-echogenicity-in-substantia-nigra-a-cross-sectional-study
#3
Shu-Yang Yu, Chen-Jie Cao, Li-Jun Zuo, Ze-Jie Chen, Teng-Hong Lian, Fang Wang, Yang Hu, Ying-Shan Piao, Li-Xia Li, Peng Guo, Li Liu, Qiu-Jin Yu, Rui-Dan Wang, Piu Chan, Sheng-di Chen, Xiao-Min Wang, Wei Zhang
BACKGROUND: Transcranial ultrasound is a useful tool for providing the evidences for the early diagnosis and differential diagnosis of Parkinson disease (PD). However, the relationship between hyper echogenicity in substantia nigra (SN) and clinical symptoms of PD patients remains unknown, and the role of dysfunction of iron metabolism on the pathogenesis of SN hyper echogenicity is unclear. METHODS: PD patients was detected by transcranial sonography and divided into with no hyper echogenicity (PDSN-) group and with hyper echogenicity (PDSN+) group...
January 17, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29334499/cognitive-function-and-its-risk-factors-among-older-us-adults-living-at-home
#4
William Dale, Ashwin A Kotwal, Joseph W Shega, L Philip Schumm, David W Kern, Jayant M Pinto, Kelly M Pudelek, Linda J Waite, Martha K McClintock
BACKGROUND: The Montreal Cognitive Assessment (MoCA) has not been administered to a representative national sample, precluding comparison of patient scores to the general population and for risk factor identification. METHODS: A validated survey-based adaptation of the MoCA (MoCA-SA) was administered to a probability sample of home-dwelling US adults aged 62 to 90, using the National Social Life, Health, and Aging Project (n=3129), yielding estimates of prevalence in the United States...
January 12, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29319601/the-moca-memory-index-score-an-efficient-alternative-to-paragraph-recall-for-the-detection-of-amnestic-mild-cognitive-impairment
#5
Antarpreet Kaur, Steven D Edland, Guerry M Peavy
OBJECTIVE: To compare ability of 2 measures of delayed memory (word list, story paragraph) to discriminate Normal Control (NC) subjects from those with amnestic mild cognitive impairment (aMCI). METHODS: Demographic, neuropsychological, and diagnostic data contributed by 34 Alzheimer's Disease Centers to the National Alzheimer's Coordinating Center characterized 2717 individuals with a diagnosis of either NC (n=2205) or aMCI (n=512). The Montreal Cognitive Assessment-Memory Index Score (MoCA-MIS) assessed delayed word recall, and the Craft Story 21, delayed story recall...
January 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29316782/validation-of-the-conversion-between-the-mini-mental-state-examination-and-montreal-cognitive-assessment-in-korean-patients-with-parkinson-s-disease
#6
Ryul Kim, Han-Joon Kim, Aryun Kim, Mi-Hee Jang, Hyun Jeong Kim, Beomseok Jeon
Objective: Two conversion tables between the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) have recently been established for Parkinson's disease (PD). This study aimed to validate them in Korean patients with PD and to evaluate whether they could be influenced by educational level. Methods: A total of 391 patients with PD who undertook both the Korean MMSE and the Korean MoCA during the same session were retrospectively assessed...
January 11, 2018: Journal of Movement Disorders
https://www.readbyqxmd.com/read/29315714/brain-abnormalities-in-cognition-anxiety-and-depression-regulatory-regions-in-adolescents-with-single-ventricle-heart-disease
#7
Nancy A Pike, Bhaswati Roy, Ritika Gupta, Sadhana Singh, Mary A Woo, Nancy J Halnon, Alan B Lewis, Rajesh Kumar
BACKGROUND: Single ventricle heart disease (SVHD) adolescents show cognitive impairments and anxiety and depressive symptoms, indicating the possibility of brain injury in regions that control these functions. However, brain tissue integrity in cognition, anxiety, and depression regulatory sites in SVHD remains unclear. We examined brain tissue changes in SVHD compared to controls using T2-relaxometry procedures, which measure free water content and show tissue injury. METHODS: Proton-density and T2-weighted images, using a 3...
January 6, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29304951/left-atrial-appendage-angiography-is-associated-with-the-incidence-and-number-of-magnetic-resonance-imaging-detected-brain-lesions-after-percutaneous-catheter-based-left-atrial-appendage-closure
#8
Andreas Rillig, Barbara Bellmann, Carsten Skurk, David Manuel Leistner, Karl Georg Haeusler, Tina Lin, Rohat Geran, Luzie Koehler, Selma Guttmann, Daniel Steffens, Mario Kasner, Philipp Jakob, Verena Tscholl, Mattias Roser, Klaus Lenz, Kersten Villringer, Jai-Wun Park, Jochen B Fiebach, Ulf Landmesser
BACKGROUND: Percutaneous catheter-based left atrial appendage closure (LAAC) is a procedure being increasingly performed in patients with atrial fibrillation and high bleeding risk. OBJECTIVE: The purpose of this study was to evaluate the incidence of magnetic resonance imaging (MRI)-detected acute brain lesions (ABLs) as well as potential changes in neurocognitive function after percutaneous LAAC in patients with atrial fibrillation. METHODS: Brain MRI at 3 T was performed within 24 hours before and after LAAC along with neurologic (National Institutes of Health Stroke Scale [NIHSS] score) and cognitive (Montreal Cognitive Assessment [MoCA] test) assessment...
January 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29304177/occlusal-force-is-correlated-with-cognitive-function-directly-as-well-as-indirectly-via-food-intake-in-community-dwelling-older-japanese-from-the-sonic-study
#9
Kazunori Ikebe, Yasuyuki Gondo, Kei Kamide, Yukie Masui, Taturo Ishizaki, Yasumichi Arai, Hiroki Inagaki, Takeshi Nakagawa, Mai Kabayama, Hirochika Ryuno, Hitomi Okubo, Hajime Takeshita, Chisato Inomata, Yuko Kurushima, Yusuke Mihara, Kohdai Hatta, Motoyoshi Fukutake, Kaori Enoki, Taiji Ogawa, Ken-Ichi Matsuda, Ken Sugimoto, Ryosuke Oguro, Yoichi Takami, Norihisa Itoh, Yasushi Takeya, Koichi Yamamoto, Hiromi Rakugi, Shinya Murakami, Masahiro Kitamura, Yoshinobu Maeda
BACKGROUND: Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations. However, many previous studies on this topic used insensitive oral indicators or did not include certain essential covariates. Thus, we examined the association between occlusal force and cognitive function in a large sample of older adults, controlling for dietary intake, vascular risk factors, inflammatory biomarkers, depression, and genetic factors...
2018: PloS One
https://www.readbyqxmd.com/read/29300426/physical-frailty-is-associated-with-longitudinal-decline-in-global-cognitive-function-in-non-demented-older-adults-a-prospective-study
#10
S Chen, T Honda, K Narazaki, T Chen, H Kishimoto, Y Haeuchi, S Kumagai
OBJECTIVES: To assess the relationship between physical frailty and subsequent decline in global cognitive function in the non-demented elderly. DESIGN AND SETTING: A prospective population-based study in a west Japanese suburban town, with two-year follow-up. PARTICIPANTS: Community-dwellers aged 65 and older without placement in long-term care, and not having a history of dementia, Parkinson's disease and depression at baseline, who participated in the cohort of the Sasaguri Genkimon Study and underwent follow-up assessments two years later (N = 1,045)...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29285575/alteration-of-gray-matter-texture-features-over-the-whole-brain-in-medication-overuse-headache-using-a-3-dimentional-texture-analysis
#11
Zhiye Chen, Xiaoyan Chen, Zhiqiang Chen, Mengqi Liu, Huiguang He, Lin Ma, Shengyuan Yu
BACKGROUND: Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR structural images over the whole brain in MOH using a 3-dimentional texture analysis. METHODS: Brain three-dimensional T1-weighted structural images were obtained from 44 MOH patients and 32 normal controls (NC). The imaging processing included two steps: gray matter (gray images) segment and a 3-dimensional texture features mapping...
November 28, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29283046/vitamin-d-increases-a%C3%AE-140-plasma-levels-and-protects-lymphocytes-from-oxidative-death-in-mild-cognitive-impairment-patients
#12
Carol D San Martín, Mauricio Henriquez, Carlos Chacon, Daniela P Ponce, Felipe Salech, Nicole Rogers, María Isabel Behrens
BACKGROUND: Mild cognitive impairment (MCI) has an increased rate of progression to dementia. Alterations of some metabolic factors, such as deficiency of vitamin D, are a risk factor for cognitive deterioration. Vitamin D is involved in the clearance of β-amyloid (Aβ) from the brain. We have reported that lymphocytes from Alzheimer's disease (AD) patients have an increased susceptibility to oxidative death by H2O2 exposure, but currently it is unknown if this characteristic is modifiable in vivo...
December 27, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29276745/frequencies-of-alleles-genotypes-and-haplotypes-of-two-polymorphisms-in-the-clusterin-gene-in-the-russian-elderly-population-categorized-by-cognitive-performance
#13
Anna V Bocharova, Kseniya V Vagaitseva, Oksana A Makeeva, Andrey V Marusin, Vadim A Stepanov
This article contains data on the frequencies of alleles, genotypes and haplotypes of the single nucleotide polymorphisms (SNPs) rs2279590 and rs1532278 in the CLU gene in a cohort of normal elderly from the Russian population. The SNPs have been reported to be associated with Alzheimer's disease and cognitive functions in genome-wide and candidate genes association studies. Cognitive performance in sample set was estimated by the Montreal Cognitive Assessment (MoCA). The frequencies of alleles, genotypes and haplotypes of two SNPs were calculated in 3 groups: total sample set, sample set with MoCA score less than 21 (the first quartile) and group with MoCA score more than 24 (the fourth quartile)...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29275589/-characteristics-of-cognitive-impairment-and-the-resting-state-functional-mri-in-patients-with-leukoaraiosis
#14
Q Li, L Q Zhao, F Y Hu
Objective: To investigate the features of cognitive impairment and potential physiopathologic mechanism using neuropsychological assessment and resting state functional magnetic resonance imaging (rs-fMRI) in patients with leukoaraiosis (LA). Methods: A total of 13 patients with LA (LA group) and 13 healthy controls (NC group) from Shanxi Provincial People's Hospital between January and June 2016 were recruited. The two groups were matched for age, sex, education, and vascular risk factors. All the subjects underwent neuropsychological assessment and the scan of rs-fMRI...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29275578/-application-of-chinese-version-of-ace-%C3%A2-in-type-2-diabetes-mellitus-patients-with-mild-cognitive-impairment
#15
J W Xin, X L Xiao, X C Chen, X D Pan
Objective: To investigate the application and best cut-off value of Chinese version of Addenbrooke's cognitive examination-Ⅲ(ACE-Ⅲ) in type 2 diabetes mellitus (T2DM) patients with mild cognitive impairment. Methods: A total of 18 T2DM patients with normal cognitive function (NCI group) and 40 T2DM patients with mild cognitive impairment (MCI group) treated in outpatient clinic or ward of Department of Neurology and Endocrinology in Fujian Medical University Union Hospital between January 2015 and February 2016 were enrolled...
November 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29260029/a-structural-mri-study-of-cholinergic-pathways-and-cognition-in-multiple-sclerosis
#16
Yukio Kimura, Noriko Sato, Miho Ota, Norihide Maikusa, Tomoko Maekawa, Daichi Sone, Mikako Enokizono, Atsuhiko Sugiyama, Etsuko Imabayashi, Hiroshi Matsuda, Tomoko Okamoto, Takashi Yamamura, Hideharu Sugimoto
Background: White matter hyperintensities (WMH) in the cholinergic pathways are associated with cognitive performance in Alzheimer's disease. This study aimed to evaluate the relationship between the volume reduction of cholinergic pathways and cognitive function in patients with multiple sclerosis (MS). Methods: Thirty-two MS patients underwent a brain MRI and cognitive measurements including the Mini-Mental State Examination (MMSE) and the Japanese version of the Montreal Cognitive Assessment (MoCA-J)...
September 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29260027/does-cerebral-large-artery-disease-contribute-to-cognitive-impairment
#17
Satoshi Kimura, Toshiyasu Ogata, Junko Watanabe, Tooru Inoue, Yoshio Tsuboi
Purpose: Although many patients with cerebral large-artery disease (CLAD) show impaired cognitive performance, the risk factors remain unclear in this population. The objective of this study was to evaluate cognitive impairment and its risk factors in patients with CLAD. Methods: We recruited non-demented patients with CLAD from our hospital. CLAD was defined as occlusion or stenosis of over 50% in the carotid artery or middle cerebral artery. We collected patients' biographical data and vascular lesion and imaging data, including periventricular hyperintensity (PVH) and cerebral perfusion...
September 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29248155/validation-of-predictive-score-of-30-day-hospital-readmission-or-death-in-patients-with-heart-failure
#18
Quan Huynh, Kazuaki Negishi, Carmine G De Pasquale, James L Hare, Dominic Leung, Tony Stanton, Thomas H Marwick
Existing prediction algorithms for the identification of patients with heart failure (HF) at high risk of readmission or death after hospital discharge are only modestly effective. We sought to validate a recently developed predictive model of 30-day readmission or death in HF using an Australia-wide sample of patients. This study used data from 1,046 patients with HF at teaching hospitals in 5 Australian capital cities to validate a predictive model of 30-day readmission or death in HF. Besides standard clinical and administrative data, we collected data on individual sociodemographic and socioeconomic status, mental health (Patient Health Questionnaire [PHQ]-9 and Generalized Anxiety Disorder [GAD]-7 scale score), cognitive function (Montreal Cognitive Assessment [MoCA] score), and 2-dimensional echocardiograms...
October 31, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29243792/analysis-of-correlation-between-the-mild-cognitive-impairment-mci-and-level-of-adiponectin-in-elderly-patients-with-type-2-diabetes-mellitus-t2dm
#19
Z-Q Liu, M-X Zhang, J Wang, N Ding
OBJECTIVE: To investigate the correlation between the mild cognitive impairment (MCI) and serum level of adiponectin in elderly patients with Type II diabetes mellitus (T2DM), so as to provide evidence for early diagnosis of MCI and effective evaluation of the impairment of cognitive functions, thereby preventing the impairment of cognitive function as early as possible. PATIENTS AND METHODS: Clinical data were collected from 260 T2DM patients (≥ 60 years old) in Endocrine Department and 120 healthy subjects (≥ 60 years old) who underwent physical examination in our hospital between June 2015 and June 2017...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29238748/non-motor-symptoms-in-progressive-supranuclear-palsy-prevalence-and-severity
#20
Fabiana Giada Radicati, Pablo Martinez Martin, Chiara Fossati, Kallol Ray Chaudhuri, Margherita Torti, Carmen Rodriguez Blazquez, Laura Vacca, Fabrizio Stocchi
NMSs have been extensively studied in PD patients but not in other forms of parkinsonism such as Progressive Supranuclear Palsy (PSP). The primary objective of this study was to analyze the frequency, severity and the type of non-motor symptoms (NMS) in PSP patients using the non-motor symptoms scale (NMSS). The secondary objective was to differentiate NMS between PSP and Parkinson's disease (PD). We enrolled in this cross-sectional study 50 consecutive PSP and 100 matched Parkinson's disease (PD) patients, in the proportion PSP/PD = 1/2, matched in age, sex, and disease duration...
2017: NPJ Parkinson's Disease
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