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Psychosis in elderly

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https://www.readbyqxmd.com/read/29881765/predicting-psychiatric-hospitalizations-among-elderly-veterans-with-a-history-of-mental-health-disease
#1
Zachary Burningham, Jianwei Leng, Celena B Peters, Tina Huynh, Ahmad Halwani, Randall Rupper, Bret Hicken, Brian C Sauer
Introduction: Patient Aligned Care Team (PACT) care managers are tasked with identifying aging Veterans with psychiatric disease in attempt to prevent psychiatric crises. However, few resources exist that use real-time information on patient risk to prioritize coordinating appropriate care amongst a complex aging population. Objective: To develop and validate a model to predict psychiatric hospital admission, during a 90-day risk window, in Veterans ages 65 or older with a history of mental health disease...
May 17, 2018: EGEMS
https://www.readbyqxmd.com/read/29876595/-tapering-of-antidementia-drugs-antidepressants-and-antipsychotics-in-elderly-patients-when-possible-when-not
#2
REVIEW
K Hager, T Temps, O Krause
BACKGROUND: Antidementia drugs, antidepressants and antipsychotics are among the most frequently prescribed medication in old and multimorbid patients. Due to side effects (e. g. prolonged QTc interval) in emergency medicine/intensive care unit or patients' wishes the question is often raised whether these drugs can be stopped and how this may be done. ANTIDEMENTIA DRUGS: If the cognition is stable under antidementia drugs or if the patient is in favour of the medication, it should be continued...
June 6, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29876278/corpus-callosum-volumes-in-the-5-years-following-the-first-episode-of-schizophrenia-effects-of-antipsychotics-chronicity-and-maturation
#3
Mariana T M de Moura, Marcus V Zanetti, Fabio L S Duran, Maristela S Schaufelberger, Paulo R Menezes, Marcia Scazufca, Geraldo F Busatto, Mauricio H Serpa
Background: White matter (WM) structural changes, particularly affecting the corpus callosum (CC), seem to be critically implicated in psychosis. Whether such abnormalities are progressive or static is still a matter of debate in schizophrenia research. Aberrant maturation processes might also influence the longitudinal trajectory of age-related CC changes in schizophrenia patients. We investigated whether patients with first-episode schizophrenia-related psychoses (FESZ) would present longitudinal CC and whole WM volume changes over the 5 years after disease onset...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29803209/antipsychotics-in-hyperthyroid-related-psychosis-case-report-and-systematic-review
#4
Danielle Golub, Victor Rodack
OBJECTIVES: Hyperthyroidism has been associated with relatively rare presentations of psychotic symptoms. We report an example of the successful use of antipsychotics to manage psychotic symptoms in hyperthyroid-related psychosis. Furthermore, we systematically describe the available literature on the use of antipsychotics in this setting to determine the associated relative efficacies of the various antipsychotic agents. METHODS: Presentation of a case of hyperthyroid-related psychosis treated with an antipsychotic agent followed by a systematic review of all similar cases: PubMed, Ovid MEDLINE and PMC were searched for articles published between 1960 and 2017 that report on the use of specific antipsychotics in the management of hyperthyroid-related psychosis...
March 27, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29800937/association-between-psychosis-in-elderly-patients-with-alzheimer-disease-and-impaired-social-cognition
#5
Jeremy Koppel, Amber Sousa, Marc L Gordon, Luca Giliberto, Erica Christen, Peter Davies
No abstract text is available yet for this article.
May 6, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29785841/effects-of-antipsychotic-drugs-on-neurites-relevant-to-schizophrenia-treatment
#6
REVIEW
Xu-Feng Huang, Xueqin Song
Although antipsychotic drugs are mainly used for treating schizophrenia, they are widely used for treating various psychiatric diseases in adults, the elderly, adolescents and even children. Today, about 1.2% of the worldwide population suffers from psychosis and related disorders, which translates to about 7.5 million subjects potentially targeted by antipsychotic drugs. Neurites project from the cell body of neurons and connect neurons to each other to form neural networks. Deficits in neurite outgrowth and integrity are implicated in psychiatric diseases including schizophrenia...
May 22, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29755923/epigenetic-alterations-impact-on-antipsychotic-treatment-in-elderly-patients
#7
Bryan M McClarty, Daniel W Fisher, Hongxin Dong
Purpose of the review: Antipsychotics are commonly prescribed for the treatment of psychosis as well as behavioral and psychological symptoms of dementia (BPSD) in elderly patients. However, elderly patients often experience decreased antipsychotic efficacy and increased side effects, though the mechanisms underlying these changes with age are not clear. Recent findings: Although aging can affect drug metabolism and clearance through changes in renal and hepatic function, additional pharmacokinetic and pharmacodynamic changes due to aging-induced epigenetic alterations also impact processes important for antipsychotic function...
March 2018: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/29576036/introducing-a-family-intervention-to-elderly-with-first-episode-psychosis
#8
Tuula Saarela, Monica Johansson, Ullamarja Louhija, Björn Appelberg, Kati Juva
Schizophrenia guidelines list family interventions as an efficient means in reducing relapses. Interventions aim to help families cope with their relative's problems more effectively, provide support and education, and reduce levels of distress and improve the family communication (see deHaan et al., 2002).
March 26, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29559949/impaired-quality-of-life-and-need-for-palliative-care-in-a-german-cohort-of-advanced-parkinson-s-disease-patients
#9
Martin Klietz, Amelie Tulke, Lars H Müschen, Lejla Paracka, Christoph Schrader, Dirk W Dressler, Florian Wegner
Background: Parkinson's disease (PD) is the second most frequent neurodegenerative disease of the elderly. Patients suffer from various motor and non-motor symptoms leading to reduced health-related quality of life (HRQOL) and an increased mortality. Their loss of autonomy due to dementia, psychosis, depression, motor impairments, falls, and swallowing deficits defines a phase when palliative care interventions might help to sustain or even improve quality of life. Objective: The aim of this study was to investigate the current status of palliative care implementation and quality of life in a local cohort of advanced PD patients in order to frame and improve future care...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29553944/psychosis-in-cognitively-asymptomatic-elderly-subjects-is-associated-with-neuritic-plaque-load-not-neurofibrillary-tangles
#10
Julia Kim, Tom A Schweizer, Corinne E Fischer, David G Munoz
INTRODUCTION: Despite having severe Alzheimer disease pathology, some individuals remain cognitively asymptomatic (cASYM). To explore noncognitive manifestations in these cASYM individuals, we aim to investigate the prevalence and pathologic substrates of psychosis. METHODS: Data were obtained from the National Alzheimer's Coordinating Center. The Neuropsychiatric Inventory Questionnaire, quick version was used to evaluate presence of psychosis. Subjects with Mini-Mental Status Examination score of ≥24 with frequent neuritic plaques (NPs) were defined as NPcASYM, and those with Braak and Braak stage of neurofibrillary tangles of V/VI were defined as NTcASYM (both groups collectively designated cASYM)...
March 16, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29455628/ng%C3%A4-whak%C3%A4-whitinga-standing-at-the-crossroads-how-m%C3%A4-ori-understand-what-western-psychiatry-calls-schizophrenia
#11
Melissa Taitimu, John Read, Tracey McIntosh
This project explored how Māori understand experiences commonly labelled "schizophrenic" or "psychotic". Semi-structured interviews were conducted with 57 Māori participants who had either personal experiences labelled as "psychosis" or "schizophrenia", or who work with people with such experiences; including tangata whaiora (users of mental health services), tohunga (traditional healers), kaumatua/kuia (elders), Māori clinicians, cultural support workers and students...
April 2018: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29412850/electroconvulsive-therapy-in-geriatric-psychiatry-a-selective-review
#12
REVIEW
Justin P Meyer, Samantha K Swetter, Charles H Kellner
Electroconvulsive therapy (ECT) remains an important treatment of geriatric patients. ECT treats severe depression, mania, psychosis, catatonia, and comorbid depression and agitation in dementia. ECT also serves a crucial role in treating urgent illness requiring expedient recovery, such as catatonia, or in patients with severe suicidal ideation or intent. ECT is even more effective in the elderly than in mixed-age adult populations. ECT is a safe treatment option with few medical contraindications. Cognitive effects are largely transient, even in patients with preexisting cognitive impairment...
March 2018: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/29400103/-four-year-follow-up-of-a-neurosyphilis-case-presenting-psychiatric-symptoms
#13
László Tombor, Pál Salacz, Éva Jankelovics, Zoltán Hidasi
The authors present a case of neurosyphilis associated with predominant psychiatric symptoms. The elderly man was admitted because of confused behavior, maniform state, lack of critical judgement and grandiose delusions. On admission, right central facial nerve paresis, hand tremor and parkinsonism were also found. Acute brain imaging and routine laboratory tests failed to identify a firm etiology of the confusional state. The psychiatric treatment resulted in complete recovery from delirium. Afterwards, maniform psychosis dominated the clinical picture for which antipsychotics were administered...
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29209479/a-brief-psychotic-episode-with-depressive-symptoms-in-silent-right-frontal-lobe-infarct
#14
Salziyan Badrin, Noraini Mohamad, Nor Akma Yunus, Maryam Mohd Zulkifli
Psychiatric symptoms may be related to a silent cerebral infarct, a phenomenon that has been described previously in literature. Acute psychosis or other neuropsychiatric symptoms including depression may present in stroke patients and patients with lesions either within the prefrontal or occipital cortices, or in subcortical areas such as the basal ganglia, thalamus, mid-brain, and brainstem. Psychosis in clinical stroke or in silent cerebral infarction is uncommon and not well documented in the literature...
November 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29167723/the-impact-of-audio-book-on-the-elderly-mental-health
#15
Fereshteh Ameri, Naser Vazifeshenas, Abbas Haghparast
Introduction: The growing elderly population calls mental health professionals to take measures concerning the treatment of the elderly mental disorders. Today in developed countries, bibliotherapy is used for the treatment of the most prevalent psychiatric disorders. Therefore, this study aimed to investigate the effects of audio book on the elderly mental health of Retirement Center of Shahid Beheshti University of Medical Sciences. Methods: This experimental study was conducted on 60 elderly people participated in 8 audio book presentation sessions, and their mental health aspects were evaluated through mental health questionnaire (SCL-90-R)...
September 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/29145187/diogenes-syndrome
#16
Frédéric Assal
Diogenes syndrome (DS) is not a specific disease but a real neurobehavioral syndrome, characterized by severe domestic squalor, pathological hoarding, lack of insight into the condition, and no need for help. DS can be secondary when associated to psychosis or bipolar disorder, or primary when it occurs as a single entity, usually in the elderly. DS is a clinically complex transnosographic syndrome for which multidimensional approaches need to be considered: medical, psychiatric, neurological, social, scientific, and ethical...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/28906054/neuropathological-comorbidity-associated-with-argyrophilic-grain-disease
#17
REVIEW
Osamu Yokota, Tomoko Miki, Chikako Ikeda, Shigeto Nagao, Shintaro Takenoshita, Hideki Ishizu, Takashi Haraguchi, Shigetoshi Kuroda, Seishi Terada, Norihito Yamada
Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8% to 80%. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41...
February 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28671925/ophthalmic-timolol-hallucinations-a-case-series-and-review-of-the-literature
#18
REVIEW
Tavish Nanda, Nailyn Rasool, Alison B Callahan, Robert L Stamper, Jeffrey G Odel
PURPOSE: Systemic absorption and central nervous system (CNS) penetration of timolol drops are a well-studied phenomenon, resulting in common side effects such as bradycardia, bronchospasm, fatigue, and confusion. More serious CNS side effects, such as psychosis and depression, however, are rarely attributed to eye drops. We report a case series in which patients developed visual hallucinations secondary to topical ocular timolol use. METHODS: This study is a case series and review of the literature...
September 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28658884/post-stroke-psychosis-following-lesions-in-basal-ganglion
#19
Shruti Srivastava, Mukul P Agarwal, Ankur Gautam
Stroke is the second most common cause of death and fourth leading cause of disability worldwide. Post stroke behavioural manifestations are often not recognized, undiagnosed and hence remain untreated. They may even suffer from misdiagnosis of functional disorders before coming at conclusion of organic pathology. Early diagnosis and prompt treatment helps in lowering the overall morbidity related to stroke and improves quality of life of these patients with rare manifestations. Here, we report two cases of elderly female patients presenting with delusions and hallucinations subsequent to stroke, with lesions in basal ganglia detected on neuro-imaging...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28587701/brain-atrophy-is-a-frequent-finding-in-elderly-patients-with-first-episode-psychosis
#20
Ulla-Marja Louhija, Tuula Saarela, Kati Juva, Björn Appelberg
BACKGROUND: To characterize the yearly incidence, diagnostic distribution, and neuro-radiologic findings in patients aged over 60 years, referred to psychiatric treatment with first episode psychosis (FEP). METHODS: A computerized search, including all patients referred to psychiatric treatment during 12 consecutive months with a de novo diagnosis of psychosis was performed in the Helsinki region catchment area with 1.2 million inhabitants. Diagnoses based on hospital records were made by a group of one neurologist and three psychiatrists...
June 7, 2017: International Psychogeriatrics
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