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reproductive immunology

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https://www.readbyqxmd.com/read/29775752/the-genetics-and-molecular-pathogenesis-of-systemic-lupus-erythematosus-sle-in-populations-of-different-ancestry
#1
REVIEW
George N Goulielmos, Maria I Zervou, Vassilis M Vazgiourakis, Yogita Ghodke-Puranik, Alexandros Garyfallos, Timothy B Niewold
Systemic lupus erythematosus (SLE; OMIM 152700) is a highly heterogeneous disorder, characterized by differences in autoantibody profile, serum cytokines, and a multi-system involvement commonly affecting the skin, renal, musculoskeletal, and hematopoetic systems clinical manifestations involving. Disease features range from mild manifestations, such as rash or arthritis, to life-threatening end-organ manifestations, such as glomerulonephritis or thrombosis, and it is difficult to predict which manifestations will affect a given patient...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29718478/developmental-exposure-to-a-mixture-of-23-chemicals-associated-with-unconventional-oil-and-gas-operations-alters-the-immune-system-of-mice
#2
Lisbeth A Boulé, Timothy J Chapman, Sara E Hillman, Christopher D Kassotis, Colleen O'Dell, Jacques Robert, Steve N Georas, Susan C Nagel, B Paige Lawrence
Chemicals used in unconventional oil and gas (UOG) operations have the potential to cause adverse biological effects, but this has not been thoroughly evaluated. A notable knowledge gap is their impact on development and function of the immune system. Herein, we report an investigation of whether developmental exposure to a mixture of chemicals associated with UOG operations affects the development and function of the immune system. We used a previously characterized mixture of 23 chemicals associated with UOG, and which was demonstrated to affect reproductive and developmental endpoints in mice...
May 1, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29699959/current-management-of-gynecologic-cancer-in-pregnancy
#3
Christos Iavazzo, Evelyn Eleni Minis, Ioannis D Gkegkes
Cancer during pregnancy is a particularly challenging complication. The incidence has increased in recent years due to childbering at an advanced maternal age due to career choices and/or the development of reproductive technology. Approximately two thirds of cancer cases during pregnancy are comprised of invasive cervical cancers and breast cancer. Cancer during gestation is characterized by a need for specialized treatment due to major changes in the hormonal profile (estrogen-progesterone), metabolism (enhancement of anabolism), hemodynamic changes (hyperdynamic circulation), immunologic changes (cell mediated and humoral immunity), increased angiogenesis (increased blood flow towards the uterus)...
April 27, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29692668/immune-modulation-of-i-v-immunoglobulin-in-women-with-reproductive-failure
#4
REVIEW
Ae R Han, Sung K Lee
Background: The mechanism of maternal immune tolerance of the semi-allogenic fetus has been explored extensively. The immune reaction to defend from invasion by pathogenic microorganisms should be maintained during pregnancy. An imbalance between the immune tolerance to the fetus and immune activation to the pathogenic organisms is associated with poor pregnancy outcomes. This emphasizes that the immune mechanism of successful reproduction is not just immune suppression, but adequate immune modulation...
April 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29688269/polycystic-ovary-syndrome-possible-involvement-of-androgen-induced-chemerin-mediated-ovarian-recruitment-of-monocytes-macrophages
#5
Patricia D A Lima, Anne-Laure Nivet, Qi Wang, Yi-An Chen, Arthur Leader, Annie Cheung, Chii-Ruey Tzeng, Benjamin K Tsang
Polycystic ovary syndrome (PCOS) is a continuum of endocrine and reproductive disorders characterized by hyperandrogenism, antral follicle growth arrest and chronic inflammation. Macrophages play key role in inflammation and the balance between M1 (inflammatory) and M2 (anti-inflammatory) macrophages determines physiological/pathological outcomes. Here, we investigated if hyperandrogenism increases ovarian chemerin altering the balance of M1 and M2 macrophages and the granulosa cell death. Ovarian chemerin was up-regulated by 5α-dihydrotestosterone (DHT) in lean and overweight rats; while increased serum chemerin levels were only evident in overweight rats, suggesting that the serum chemerin may be reflective of a systemic response and associated with obesity, whereas increased ovarian chemerin expression is a localized response independent of the metabolic status...
April 24, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29680457/recommendations-regarding-the-genetic-and-immunological-study-of-reproductive-dysfunction
#6
María Concepción Alonso-Cerezo, Mercedes Calero Ruiz, Venancio Chantada-Abal, Luis Alfonso de la Fuente-Hernández, Inmaculada García-Cobaleda, Carlos García-Ochoa, José Miguel García-Sagredo, Rocío Nuñez, Rafael Oliva, María Orera-Clemente, David Pintado-Vera, Silvia Sanchez-Ramon
In this article several members of diverse scientific associations and reproduction experts from Spain have updated different genetic and immunological procedure recommendations in couples affected by reproductive dysfunction with the goal of providing a set of useful guidelines for the clinic. The laboratory test has been considered as highly recommendable for making clinical decisions when the result of the diagnostic test is relevant, moderately recommendable when the results are of limited evidence because they are inconsistent, and low when the benefit of the test is uncertain...
April 19, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29665530/the-burden-of-disease-attributable-to-ambient-pm2-5-bound-pahs-exposure-in-nagpur-india
#7
Tunde O Etchie, Saravanadevi Sivanesan, Ayotunde T Etchie, Gregory O Adewuyi, Kannan Krishnamurthi, K V George, Padma S Rao
Exposure to PM2.5 -bound polycyclic aromatic hydrocarbons (PAHs) can elicit several types of cancer and non-cancer effects. Previous studies reported substantial burdens of PAH-induced lung cancer, but the burdens of other cancer types and non-cancer effects remain unknown. Thus, we estimate the cancer and non-cancer burden of disease, in disability-adjusted life years (DALYs), attributable to ambient PM2.5 -bound PAHs exposure in Nagpur district, India, using risk-based approach. We measured thirteen PAHs in airborne PM2...
April 11, 2018: Chemosphere
https://www.readbyqxmd.com/read/29628283/weathering-the-storm-a-review-of-pre-pregnancy-stress-and-risk-of-spontaneous-abortion
#8
REVIEW
Tyralynn Frazier, Carol J Rowland Hogue, Elizabeth A Bonney, Kathryn M Yount, Brad D Pearce
The Weathering Effect is a theory that links stress exposure, over the life-course, with racial disparities in reproductive outcomes, through the effects of social adversity on a woman's body. The concept of maternal "weathering" captures cumulative somatic and psychological adversities that can exacerbate the effects of aging. Much of the evidence for weathering comes from observational studies linking self-report measures with reproductive outcomes. The purpose of this review is to explore biological mechanisms that underlie these observations...
March 1, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29625402/effect-of-tropical-thermal-stress-on-peri-implantation-immune-responses-in-cows
#9
Mohanned Naif Alhussien, Aarti Kamboj, Mustafa Ahmad Aljader, Bibhudatta S K Panda, Munna Lal Yadav, Lakshit Sharma, Seid Mohammed, Aasif Ahmad Sheikh, Masoud Lotfan, Rajeev Kapila, A K Mohanty, Ajay Kumar Dang
Pregnancy losses during the peri-implantation period cause a negative impact on the reproductive and economic performance of dairy herds. In this study, we investigated the possible immunological factors which may contribute to pregnancy loss during the peri-implantation period under different seasons of tropical conditions. Eighteen Karan Fries cows, six cows in each season (W: winter; HH: hot-humid; HD: hot-dry) were selected. These cows exhibited heat and were brought for artificial insemination (AI; day 0)...
March 29, 2018: Theriogenology
https://www.readbyqxmd.com/read/29621960/experimental-uterus-transplant-in-various-models-review-of-surgical-techniques
#10
Jalal Arvin, Maryam Ashrafi, Saeedeh Lotfi, Arash Dadvand Meshgin Shahr, Elvira Schomann, Kristina Scheerer, Elke Schulmeyer
Uterus transplantation may become the surgical therapeutic modality of choice for uterine factor infertility. However, this procedure still faces technical, therapeutic, and immunologic challenges that limit its success and clinical application. Experimental studies are therefore still needed to address various challenges in the field of uterus transplantation. Among various laboratory animals, small animals are ideal models for the purpose of experimental uterus transplant. However, clinical success in small animal models is not generalizable to clinical application and treatment for uterine factor infertility in humans...
April 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29566643/genomic-selection-signatures-in-sheep-from-the-western-pyrenees
#11
Otsanda Ruiz-Larrañaga, Jorge Langa, Fernando Rendo, Carmen Manzano, Mikel Iriondo, Andone Estonba
BACKGROUND: The current large spectrum of sheep phenotypic diversity results from the combined product of sheep selection for different production traits such as wool, milk and meat, and its natural adaptation to new environments. In this study, we scanned the genome of 25 Sasi Ardi and 75 Latxa sheep from the Western Pyrenees for three types of regions under selection: (1) regions underlying local adaptation of Sasi Ardi semi-feral sheep, (2) regions related to a long traditional dairy selection pressure in Latxa sheep, and (3) regions experiencing the specific effect of the modern genetic improvement program established for the Latxa breed during the last three decades...
March 22, 2018: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/29563662/understanding-immune-function-as-a-pace-of-life-trait-requires-environmental-context
#12
REVIEW
B Irene Tieleman
This article provides a brief historical perspective on the integration of physiology into the concept of the pace of life of birds, evaluates the fit of immune function into this framework, and asks what it will take to fruitfully understand immune functioning of birds in pace of life studies in the future. In the late 1970s, physiology started to seriously enter avian life history ecology, with energy as the main currency of interest, inspired by David Lack's work in the preceding decades emphasizing how food availability explained life history variation...
2018: Behavioral Ecology and Sociobiology
https://www.readbyqxmd.com/read/29553138/interferon-%C3%AE-induced-in-female-genital-epithelium-by-hiv-1-glycoprotein-120-via-toll-like-receptor-2-pathway-acts-to-protect-the-mucosal-barrier
#13
Aisha Nazli, Sara Dizzell, Muhammad Atif Zahoor, Victor H Ferreira, Jessica Kafka, Matthew William Woods, Michel Ouellet, Ali A Ashkar, Michel J Tremblay, Dawn Me Bowdish, Charu Kaushic
More than 40% of HIV infections occur via female reproductive tract (FRT) through heterosexual transmission. Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens. These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses. Previously, we have shown that in response to HIV-1 gp120, the genital epithelial cells (GECs) from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection...
March 19, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29549333/bat-mouse-bone-marrow-chimera-a-novel-animal-model-for-dissecting-the-uniqueness-of-the-bat-immune-system
#14
Kylie Su Mei Yong, Justin Han Jia Ng, Zhisheng Her, Ying Ying Hey, Sue Yee Tan, Wilson Wei Sheng Tan, Sergio Erdal Irac, Min Liu, Xue Ying Chan, Merry Gunawan, Randy Jee Hiang Foo, Dolyce Hong Wen Low, Ian Hewitt Mendenhall, Yok Teng Chionh, Charles-Antoine Dutertre, Qingfeng Chen, Lin-Fa Wang
Bats are an important animal model with long lifespans, low incidences of tumorigenesis and an ability to asymptomatically harbour pathogens. Currently, in vivo studies of bats are hampered due to their low reproduction rates. To overcome this, we transplanted bat cells from bone marrow (BM) and spleen into an immunodeficient mouse strain NOD-scid IL-2R-/- (NSG), and have successfully established stable, long-term reconstitution of bat immune cells in mice (bat-mice). Immune functionality of our bat-mouse model was demonstrated through generation of antigen-specific antibody response by bat cells following immunization...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29538673/recurrent-pregnancy-loss-evaluation-combined-with-24-chromosome-microarray-of-miscarriage-tissue-provides-a-probable-or-definite-cause-of-pregnancy-loss-in-over-90-of-patients
#15
F Popescu, C R Jaslow, W H Kutteh
STUDY QUESTION: Will the addition of 24-chromosome microarray analysis on miscarriage tissue combined with the standard American Society for Reproductive Medicine (ASRM) evaluation for recurrent miscarriage explain most losses? SUMMARY ANSWER: Over 90% of patients with recurrent pregnancy loss (RPL) will have a probable or definitive cause identified when combining genetic testing on miscarriage tissue with the standard ASRM evaluation for recurrent miscarriage...
March 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29474132/who-s-the-target-mother-or-baby
#16
Alisa Kachikis, Linda O Eckert, Janet Englund
Maternal immunization for prevention of morbidity and mortality of pregnant women and their neonates due to infectious diseases is ongoing worldwide. The complexity of vaccine research and development in this population is challenging. Not only do vaccines for pregnant women require evidence of immunogenicity, potency, stability, and limited reactogenicity, they must also provide efficacy in decreasing morbidity for the pregnant woman, her fetus, and the neonate, demonstrate safety or lack of evidence of harm, and offer benefit or potential benefit of vaccination during pregnancy...
March 2018: Viral Immunology
https://www.readbyqxmd.com/read/29471443/immunomodulatory-potential-of-dietary-soybean-derived-isoflavones-and-saponins-in-pigs
#17
Brooke Nicole Smith, Ryan Neil Dilger
In this review, the potential for use of soy-derived bioactive compounds as immunomodulatory feed additives in pigs is discussed. Soy is a major component of the modern U.S. swine diet in today's commercial industry, providing the bulk of dietary AA necessary for growth and production. However, soy use has generally been limited in early growth phases, during which the risks of immunological insult and disease are among the highest. Improvements of soybean processing and development of soy protein products with little to no antinutritional factors have made soy more appropriate for use in young pigs but additional processing may affect bioactive compound levels in the feed...
April 14, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29460338/mdscs-drive-the-process-of-endometriosis-by-enhancing-angiogenesis-and-are-a-new-potential-therapeutic-target
#18
Tao Zhang, Juhua Zhou, Gene Chi Wai Man, Kam Tong Leung, Bo Liang, Bo Xiao, Xinting Ma, Shaoyan Huang, Huaxiang Huang, Venkatesh L Hegde, Yin Zhong, Yanmin Li, Grace Wing Shan Kong, Alice Ka Wah Yiu, Joseph Kwong, Pak Cheung Ng, Bruce A Lessey, Prakash S Nagarkatti, Mitzi Nagarkatti, Chi Chiu Wang
Endometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here, we found MDSCs significantly increased in the peripheral blood of patients with endometriosis and in the peritoneal cavity of a mouse model of surgically induced endometriosis. Majority of MDSCs were granulocytic, produced ROS, and arginase, and suppressed T-cell proliferation...
February 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29456247/b-cells-are-the-predominant-mediators-of-early-systemic-viral-dissemination-during-rectal-lcmv-infection
#19
Martin Trapecar, Shahzada Khan, Benjamin L Cohn, Frank Wu, Shomyseh Sanjabi
Determining the magnitude of local immune response during mucosal exposure to viral pathogens is critical to understanding the mechanism of viral pathogenesis. We previously showed that vaginal inoculation of lymphocytic choriomeningitis virus (LCMV) fails to induce a robust innate immune response in the lower female reproductive tract (FRT), allowing high titer viral replication and a delay in T-cell-mediated viral control. Despite this immunological delay, LCMV replication remained confined mainly to the FRT and the draining iliac lymph node...
February 19, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29453577/computational-methods-involved-in-evaluating-the-toxicity-of-the-reproductive-toxicants-in-sertoli-cell
#20
Pranitha Jenardhanan, Manivel Panneerselvam, Premendu P Mathur
The Sertoli cell, the somatic component of seminiferous tubule, provides nutritional support and immunological protection and supports overall growth and division of germ cells. Cytoskeletons, junction proteins, and kinases in Sertoli cells are prime targets for reproductive toxicants and other environmental contaminants. Among the varied targets, the kinases that are crucial for regulating varied activities in spermatogenesis such as assembly/disassembly of blood-testis barrier and apical ES and those that are involved in conferring polarity are highly targeted...
2018: Methods in Molecular Biology
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