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https://www.readbyqxmd.com/read/29153842/stress-activated-nrf2-mdm2-cascade-controls-neoplastic-progression-in-pancreas
#1
Jelena Todoric, Laura Antonucci, Giuseppe Di Caro, Ning Li, Xuefeng Wu, Nikki K Lytle, Debanjan Dhar, Sourav Banerjee, Johan B Fagman, Cecille D Browne, Atsushi Umemura, Mark A Valasek, Hannes Kessler, David Tarin, Michael Goggins, Tannishtha Reya, Maria Diaz-Meco, Jorge Moscat, Michael Karin
Despite expression of oncogenic KRAS, premalignant pancreatic intraepithelial neoplasia 1 (PanIN1) lesions rarely become fully malignant pancreatic ductal adenocarcinoma (PDAC). The molecular mechanisms through which established risk factors, such as chronic pancreatitis, acinar cell damage, and/or defective autophagy increase the likelihood of PDAC development are poorly understood. We show that accumulation of the autophagy substrate p62/SQSTM1 in stressed Kras(G12D) acinar cells is associated with PDAC development and maintenance of malignancy in human cells and mice...
November 7, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29121082/the-mouse-model-of-pancreatic-cancer-atlas-mmpca-for-classification-of-pancreatic-cancer-lesions-a-large-histological-investigation-of-the-ptf1acre-lsl-krasg12d-transgenic-mouse-model-of-pancreatic-cancer
#2
Michelle J Veite-Schmahl, Adam C Rivers, Daniel P Regan, Michael A Kennedy
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading forms of cancer related deaths in the United States. With limited treatment options and unreliable diagnostic methods, long-term survival rates following a diagnosis of pancreatic cancer remain poor. Pancreatic intraepithelial neoplasia (PanIN) are precancerous lesions that precede progression towards PDAC. PanIN occur in increasing complexity as the disease progresses and the description of PanIN plays a critical role in describing, staging and diagnosing PDAC...
2017: PloS One
https://www.readbyqxmd.com/read/29098308/-early-endocrine-neoplasia-of-the-pancreas
#3
REVIEW
V Fendrich, D K Bartsch
Pancreatic endocrine neoplasias (pNENs) are uncommon but fascinating tumors with a rising incidence. In accordance to its location, size and grading, the decision to operate the patient should always be made in an interdisciplinary approach. This article provides a comprehensive review of the current literature addressing the current challenges in pNEN surgery and shows that patients with completely resected small pNENs generally have an excellent prognosis, but also that surveillance may be a powerful tool...
November 2, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29079172/akr1b10-expression-by-immunohistochemistry-in-surgical-resections-and-fine-needle-aspiration-cytology-material-in-patients-with-cystic-pancreatic-lesions-potential-for-improved-non-operative-diagnosis
#4
Joseph P Connor, Karla Esbona, Kristina A Matkowskyj
Cystic pancreatic tumors account for 10% of cystic lesions in the pancreas. Evaluation focuses on identifying lesions that require surgical resection due to actual or potential malignancy. Cystic tumors with malignant potential include mucinous cystic neoplasms (MCN), intraductal papillary mucinous neoplasm (IPMN), and cystic neuroendocrine tumors. The sensitivity of endoscopic fine-needle aspiration (FNA) to diagnose such lesions is low and a more accurate marker of malignant potential is needed. Aldo-keto reductase 1B10 (AKR1B10) was originally found in human hepatocellular carcinoma...
October 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29072081/cystic-pancreatic-neuroendocrine-tumors-cpnets-a-systematic-review-and-meta-analysis-of-case-series
#5
Luis Hurtado-Pardo, Javier A Cienfuegos, Miguel Ruiz-Canela, Pablo Panadero, Alberto Benito, José Luis Hernández Lizoain
Cystic pancreatic neuroendocrine tumors represent 13% of all neuroendocrine tumors. The aim of this study is to analyze the phenotype and biologic behavior of resected cystic neuroendocrine tumors. A systematic review and meta-analysis were conducted until September 2016 using a search in Medline, Scopus, and EMBASE with the terms "cystic pancreatic endocrine neoplasm", "cystic islets tumors" and "cystic islets neoplasms". From the 795 citations recovered 80 studies reporting on 431 patients were selected. 87...
November 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29070772/coexisting-thymic-and-pulmonary-carcinoid-tumors-associated-with-multiple-endocrine-neoplasia-type1
#6
Makoto Motoishi, Kanna Horimoto, Kazuki Hayashi, Satoru Sawai, Koki Moriyoshi
An anterior mediastinal tumor was detected in a 45-year-old female during a medical checkup. Chest computed tomography (CT) showed the anterior mediastinal tumor and a pulmonary tumor in the right lower lobe. Furthermore, tumors of the parathyroid gland, pancreas, and pituitary gland were also detected. She was clinically diagnosed with multiple endocrine neoplasia type1 (MEN1). The patient underwent extended thymectomy combined with mediastinal lymph node dissection and wedge resection of the lung including the right pulmonary lesion via a median sternotomy...
October 26, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29057508/impact-of-antiviral-prophylaxis-in-adults-ebv-seronegative-kidney-recipients-on-early-and-late-ptld-onset-a-retrospective-cohort-study
#7
Simon Ville, Berthe-Marie Imbert-Marcille, Marianne Coste-Burel, Claire Garandeau, Aurélie Meurette, Diego Cantarovitch, Magali Giral, Maryvonne Hourmant, Gilles Blancho, Jacques Dantal
Post-transplantation lympho-proliferative disorder (PTLD) pathogenesis is related to EBV infection. Mismatch with the donor (EBV D+/R-) is the main risk factor for both early PTLD (< 1 year post transplantation) and late (> 1 year). In these at-risk patients, the role of antiviral prophylaxis for preventing PTLD remains controversial. We analysed the impact of antiviral drugs given to prevent CMV disease in a mono-centric retrospective cohort of 73 adult kidney or kidney-pancreas EBV seronegative recipients, transplanted between 01/01/2000 and 01/01/2016...
October 23, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29050937/integrated-expression-profiling-of-potassium-channels-identifys-kcnn4-as-a-prognostic-biomarker-of-pancreatic-cancer
#8
Shuheng Jiang, Lili Zhu, Jianyu Yang, Lipeng Hu, Jianren Gu, Xin Xing, Yongwei Sun, Zhigang Zhang
Dysregulated potassium (K(+)) channels have previously been shown to promote the development and progression of many types of cancers. Meanwhile, K(+) channels are particularly important in regulating the endocrine and exocrine functions of pancreas. However, the expression pattern and prognostic significance of K(+) channels in pancreatic ductal adenocarcinoma (PDAC) remain unknown. In this study, by screening a GEO dataset containing 36 microdissected PDAC and matching normal pancreatic tissue samples, four differentially expressed K(+) channels (KCNJ5, KCNJ16, KCNN4 and KCNK1) were identified in PDAC...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29024476/prevalence-and-outcomes-of-cystic-lesions-of-the-transplant-pancreas-the-university-of-wisconsin-experience
#9
Talal M Al-Qaoud, Eric J Martinez, Hans W Sollinger, Dixon B Kaufman, Robert R Redfield, Bridget Welch, Glen Leverson, Jon S Odorico
Literature on the behavior of cystic lesions in pancreas transplants is scarce, and hence a better understanding is warranted. Data on recipients and their respective donors that underwent simultaneous kidney and pancreas, pancreas transplant alone, and pancreas after kidney between 1994-2015 were reviewed (n=1185). Cystic lesions of the transplant pancreas developed in 22 patients (1.8%): 12 pseudocysts, 2 cysts/remnants, 4 intraductal papillary mucinous neoplasms (IPMN), 2 adenocarcinomas, 1 low grade intraepithelial pancreatic neoplasia, and 1 case of polycystic kidney disease...
October 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28979651/-high-grade-insulinoma-detected-in-a-patient-with-a-5-year-history-of-severe-hypoglycemias
#10
Nadia Anoun, Hamza Hasnaoui, Firdaous Ameziane Hassani, Mehdi Bourakkadi Idrissi, Abdelmalek Ousadden, Hanan El Ouahabi, Khalid Ait Taleb
Functional endocrine tumors of the pancreas are rare. Among them insulinomas are the most common types. The majority of the patients with insulinoma are between 30 and 60 years of age and 59% of them are women. Most insulinomas are sporadic tumors while 10% of them develop in patients with multiple endocrine neoplasia (MEN). Diagnosis is based on clinical examination and laboratory tests. Preoperative imaging assessment (echo-endoscopy, CT, MRI) is essential for tumor localization in more than 80% of cases...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28975996/laparoscopic-pancreaticoduodenectomy-for-tumors-of-the-head-of-pancreas-10-cases-for-a-single-center-experience
#11
F Caruso, G Alessandri, G Cesana, G Castello, M Uccelli, F Ciccarese, R Giorgi, R Villa, B Scotto, S Olmi
OBJECTIVE: The tumors of the head of the pancreas are one of the leading causes of cancer-related death in Western countries. The current gold standard for these tumors is a Whipple procedure. This procedure did not change in its surgical steps since when it was initially introduced in 1935. More recently, a laparoscopic approach with similar outcomes has been described. The aim of this paper is to describe the laparoscopic surgical technique performed in our unit, reporting single center postoperative outcomes...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28969599/genetic-analysis-of-parathyroid-and-pancreatic-tumors-in-a-patient-with-multiple-endocrine-neoplasia-type-1-using-whole-exome-sequencing
#12
Bo-Young Kim, Mi-Hyun Park, Hae-Mi Woo, Hye-Yeong Jo, Ji Hoon Kim, Hyung Jin Choi, Soo Kyung Koo
BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant hereditary disorder characterized by the presence of endocrine tumors affecting the parathyroid, pancreas, and pituitary. A heterozygous germline inactivating mutation in the MEN1 gene (first hit) may be followed by somatic loss of the remaining normal copy or somatic mutations in the MEN1 gene (second hit). Whole-exome sequencing has been successfully used to elucidate the mutations associated with the different types of tumors...
October 2, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28948203/increased-bcl-xl-expression-in-pancreatic-neoplasia-promotes-carcinogenesis-by-inhibiting-senescence-and-apoptosis
#13
Kenji Ikezawa, Hayato Hikita, Minoru Shigekawa, Kiyoshi Iwahashi, Hidetoshi Eguchi, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
BACKGROUND & AIMS: Bcl-xL, an anti-apoptotic Bcl-2 family protein, is overexpressed in 90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, Bcl-xL expression in pancreatic intraepithelial neoplasias (PanINs) and its significance in PDAC carcinogenesis remain unclear. The aim of this study was to elucidate the significance of Bcl-xL expression in PanINs. METHODS: We investigated the expression levels of Bcl-xL in pancreas-specific KrasG12D (P-KrasG12D) mice and human PanINs and PDAC...
July 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28942303/lymphoma-koala-retrovirus-infection-and-reproductive-chlamydiosis-in-a-koala-phascolarctos-cinereus
#14
J Fabijan, L Woolford, S Lathe, G Simmons, F Hemmatzadeh, D J Trott, N Speight
Koala retrovirus (KoRV) infection, thought to be associated with lymphoid neoplasia, and Chlamydia pecorum-related ocular and urogenital disease are both highly prevalent in eastern Australian koala (Phascolarctos cinereus) populations. However, in South Australian koalas, little is known about KoRV infection and C. pecorum-associated disease. We report the first South Australian case of lymphoma in a KoRV-A-positive female koala also affected by severe reproductive chlamydiosis. The koala was from the Mount Lofty Ranges population and was presented with hindlimb lameness...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28942226/intraductal-papillary-mucinous-neoplasm-of-the-pancreas-associated-with-neuroendocrine-tumor-a-case-report
#15
M Boge, B Gurses, M Vural, S Yilmaz, S Goksel, O Bilge
INTRODUCTION: Intraductal papillary mucinous neoplasm is an uncommon cystic tumor of pancreas that can be associated with ductal adenocarcinoma. Coexistence of pancreatic IPMN and neuroendocrine tumor is very rare. Here, we report the imaging features of mixed type intraductal papillary mucinous neoplasia of the pancreas with high grade dysplasia together with neuroendocrine carcinoma and perform review of the literature. PRESENTATION: A 68-year old patient has been evaluated for possible IPMN that was suspected during ultrasound...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28902384/-multiple-endocrine-neoplasia
#16
Ludwig Schaaf, Friedhelm Raue
Multiple endocrine neoplasia type 1 and 2 are hereditary cancer syndromes. They are characterized by the occurrence of many benign and malignant tumor types, in MEN1 parathyroid tumors, pituitary tumors, and pancreas tumors, in MEN2 medullary thyroid carcinoma, pheochromocytoma, and parathyroid tumors. The autosomal dominant inherited tumor syndromes are caused by mutations in the MEN1 gene, a tumor suppressor gene, and mutations in the RET gene, an activated oncogene, in MEN2. The clinical expression of the different tumors can vary within and between families, with a good genotype-phenotype correlation in MEN2...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28870964/incidence-and-oncological-implications-of-previously-undetected-tumor-multicentricity-following-pancreaticoduodenectomy-for-pancreatic-adenocarcinoma-in-patients-undergoing-salvage-pancreatectomy
#17
Andreas Andreou, Fritz Klein, Rosa B Schmuck, Daniela Lee, Marianne Sinn, Timm Denecke, Johann Pratschke, Marcus Bahra
BACKGROUND: The risk for multicentricity of pancreatic adenocarcinoma remains unclear and the question whether pancreaticoduodenectomy represents sufficient oncological treatment for patients with ductal adenocarcinoma of the head of the pancreas needs further investigation. PATIENTS AND METHODS: Clinicopathological data of patients who underwent pancreaticoduodenectomy for pancreatic adenocarcinoma between 2005 and 2015 were assessed and the incidence of tumor multicentricity among patients who required salvage pancreatectomy within 90 postoperative days was evaluated...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28852316/serous-pancreatic-neoplasia-data-and-review
#18
Christoph F Dietrich, Yi Dong, Christian Jenssen, Valentina Ciaravino, Michael Hocke, Wen-Ping Wang, Eike Burmester, Kathleen Moeller, Nathan Ss Atkinson, Paola Capelli, Mirko D'Onofrio
AIM: To describe the imaging features of serous neoplasms of the pancreas using ultrasound, endoscopic ultrasound, computed tomography and magnetic resonance imaging. METHODS: This multicenter international collaboration enhances a literature review to date, reporting features of 287 histologically confirmed cases of serous pancreatic cystic neoplasms (SPNs). RESULTS: Female predominance is seen with most SPNs presenting asymptomatically in the 5(th) through 7(th) decade...
August 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28840303/pancreatic-cancer-screening
#19
Chris M Lindquist, Frank H Miller, Nancy A Hammond, Paul Nikolaidis
PURPOSE: This article reviews the current evidence surrounding pancreatic cancer screening. The current targets of screening include identification of early pancreatic cancer, as well as the two most important precursor lesions; intraductal papillary mucinous neoplasm and high grade pancreatic intraepithelial neoplasia. Given the relatively low incidence of pancreatic adenocarcinoma in the general population, patients with elevated risk based on family history or an underlying genetic syndrome are felt to be the most appropriate patients to undergo screening...
August 24, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28831506/-cystic-pancreatic-tumors-diagnostics-and-new-biomarkers
#20
REVIEW
A W Berger, T Seufferlein, A Kleger
Mortality due to pancreatic ductal adenocarcinoma (PDAC) will increase in the near future. The only curative treatment for PDAC is radical resection; however, even small carcinomas exhibit micrometastases leading to early relapse. Accordingly, detection of premalignant precursor lesions is important. In essence, PDAC develops from three precursor lesions: pancreatic intraepithelial lesions (PanIN), intraductal papillary-mucinous neoplasia (IPMN) and mucinous-cystic neoplasia (MCN). Together with serous cystic neoplasia (SCN) and solid pseudopapillary neoplasia (SPN), these cystic lesions constitute the most common cystic neoplasms in the pancreas...
November 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
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