pollutants

The etiology of lung cancer in never-smokers remains elusive, despite 15% of lung cancer cases in men and 53% in women worldwide being unrelated to smoking. Here, we aimed to enhance our understanding of lung cancer pathogenesis among never-smokers using untargeted metabolomics. This nested case-control study included 395 never-smoking women who developed lung cancer and 395 matched never-smoking cancer-free women from the prospective Shanghai Women's Health Study with 15,353 metabolic features quantified in pre-diagnostic plasma using liquid chromatography high-resolution mass spectrometry...

Doxorubicin (DOX) is a broad-spectrum antibiotic with potent anti-cancer activity. Nevertheless, despite having effective anti-neoplasm activity, its use has been clinically restricted due to its life-threatening side effects, such as cardiotoxicity. It is evident that betaine has anti-oxidant, and anti-inflammatory activity and has several beneficial effects, such as decreasing the amyloid-β generation, reducing obesity, improving steatosis and fibrosis, and activating AMP-activated protein kinase (AMPK)...

The Ames test is required by regulatory agencies worldwide for assessing the mutagenic and carcinogenic potential of chemical compounds. This test uses several strains of bacteria to evaluate mutation induction: positive results in the assay are predictive of rodent carcinogenicity. As an initial step to understanding how well the assay may detect mutagens present as constituents of complex mixtures such as botanical extracts, a cross-sector working group examined the within-laboratory reproducibility of the Ames test using the extensive, publicly available National Toxicology Program (NTP) Ames test database comprising more than 3000 distinct test articles, most of which are individual chemicals...

Hypertensive disorders in pregnancy (HDP) are the most prevalent diseases during pregnancy. In addition to the already identified risk factors, exposure to environmental contaminants has been also considered a new one. Phthalates, which are classified as priority environmental pollutants due to their ubiquitousness and endocrine disrupting properties, have been implicated in HDP in some epidemiological studies. Nevertheless, phthalates' vascular impacts still need to be clarified. Thus, we aimed to understand the connection between phthalates exposure and the occurrence of gestational hypertension, as well as the pathway involved in the pathological vascular effects...

Zebra mussel (ZM), Dreissena polymorpha , commonly used as a sentinel species in freshwater biomonitoring, is now in competition for habitat with quagga mussel (QM), Dreissena rostriformis bugensis. This raises the question of the quagga mussel's use in environmental survey. To better characterise QM response to stress compared with ZM, both species were exposed to cadmium (100 µg·L-1 ), a classic pollutant, for 7 days under controlled conditions. The gill proteomes were analysed using two-dimensional electrophoresis coupled with mass spectrometry...

OBJECTIVE: Evidence regarding the effects of particulate matter (PM) pollutants on cardiovascular disease (CVD) mortality remains limited in Shanghai, China. Our objective was to thoroughly evaluate associations between PM pollutants and CVD mortality. METHODS: Daily data on CVD mortality, PM (PM10 and PM2.5 ) pollutants, and meteorological variables in Shanghai, China were gathered from 2003 to 2020. We utilized a time-series design with the generalized additive model to assess associations between PM pollutants and CVD mortality...

Climate change is accompanied by changes in the exposome, including increased heat, ground-level ozone, and other air pollutants, infectious agents, pollens, and psychosocial stress. These exposures alter the internal component of the exposome and account for some of the health effects of climate change. The adverse outcome pathways describe biological events leading to an unfavorable health outcome. In this perspective study, I propose to use this toxicological framework to better describe the biological steps linking a stressor associated with climate change to an adverse outcome...

Thermal insulation materials with good flame-retardant properties have attracted widespread attention because of their huge application potential. Traditional petrochemical-based polymer insulation materials are flammable and have problems with environmental pollution. The microtubule structure is a perfect microstructure with excellent thermal insulation performance. In addition, the microtubule structure also has low density and high elasticity. Therefore, the microtubule structure is an important reference microstructure for the development of efficient thermal insulation materials...

Herein, we have isolated onion-like nanocarbon (ONC) from the exhaust soot of diesel engines and further doped it with nitrogen (N) and sulfur (S) to fabricate N,S-co-doped ONC (N-S-ONC). To explore its application feasibility, we have assembled an aqueous Zn-ion hybrid supercapacitor (ZIHSC) with a N-S-ONC cathode, which attains high specific capacitance with good rate capability. In-depth analyses suggest that the mechanism of charge storage in the ONC is governed by both capacitive-controlled and diffusion-controlled processes, with the capacitive processes leading at all sweep rates...

Environmental pollution with aromatic and aliphatic hydrocarbons caused by oil and petrochemical industries has very toxic and carcinogenic effects on living organisms and should be removed from the environment. In this research, after analyzing the oil sludge of the Bahregan area, it was found that most aliphatic paraffin compounds are related to octadecane, most liquid aliphatic compounds are related to hexadecane and most aromatic compounds are related to Naphthalene, Phenanthrene, Fluoranthene, and Anthracene...

In the current work, a rapid, simple, low-cost, and sensitive smartphone-based colorimetric sensor array coupled with pattern-recognition methods was proposed for the determination and differentiation of some organic and inorganic bases (i.e., OH- , CO3 2- , PO4 3- , NH3 , ClO- , diethanolamine, triethanolamine) as model compounds. The sensing system has been designed based on color-sensitive dyes (Fuchsine, Giemsa, Thionine, and CoCl2 ) which were used as sensor elements. The color changes of a sensor array were observed by the naked eye...

Evaluating the performance of water indices and water-related ecosystems is crucial for Ethiopia. This is due to limited information on the availability and distribution of water resources at the country scale, despite its critical role in sustainable water management, biodiversity conservation, and ecosystem resilience. The objective of this study is to evaluate the performance of seven water indices and select the best-performing indices for detecting surface water at country scale. Sentinel-2 data from December 1, 2021, to November 30, 2022, were used for the evaluation and processed using the Google Earth Engine...

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In evaluating the integrated remote sensing-based ecological index (RSEIPCA ), principal component analysis (PCA) has been extensively utilized. However, the conventional PCA-based RSEI (RSEIPCA ) cannot accurately evaluate component indicators' spatially shifting relative significance. This study presented a novel RSEI evaluation strategy based on geographically weighted principal component analysis (RSEIGWPCA ) to address this deficiency. Second, compared to the classic RSEIPCA , RSEIGWPCA was tested at English Bazar and surrounding areas using two-fold validation...

This study evaluates models for predicting volatile fatty acid (VFA) concentrations in sludge processing, ranging from classical statistical methods (Gaussian and Surge) to diverse machine learning algorithms (MLAs) such as Decision Tree, XGBoost, CatBoost, LightGBM, Multiple linear regression (MLR), Support vector regression (SVR), AdaBoost, and GradientBoosting. Anaerobic bio-methane potential tests were carried out using domestic wastewater treatment primary and secondary sludge. The tests were monitored over 40 days for variations in pH and VFA concentrations under different experimental conditions...

Exposed soils associated with active construction sites provide opportunities for erosion and sediment transport during storm events, introducing risks associated with excess sediment to downstream infrastructure and aquatic biota. A better understanding of the drivers of sediment transport in construction site runoff is needed to improve the design and performance of erosion and sediment control measures (ESCMs). Eleven monitoring locations on 3 active road construction sites in central Ohio were established to characterize runoff quality from points of concentrated flow during storm events...

Mercury (Hg) tailings are hazardous solid wastes because of their high Hg concentrations. Modified phosphogypsum (PG) can decrease the bioactivity and mobility of heavy metals through chemisorption or electrostatic interactions. In this study, PG whiskers were modified by ZnCl2 and S, chitosan-hydrochloric acid, and thioglycolic materials; the resulting modified whiskers were used to decontaminate Hg tailings. Leaching tests and orthogonal experiments were conducted to optimize the modification parameters, including modifier quantity, pH, reaction temperature, and reaction time...

Quorum quenching (QQ) is an efficient way to mitigate membrane biofouling in a membrane bioreactor (MBR) during wastewater treatment. A QQ bacterium, Lysinibacillus sp. A4, was isolated and used to mitigate biofouling in an MBR during the treatment of wastewater containing metals. A QQ enzyme (named AilY) was cloned from A4 and identified as a metallo-β-lactamase-like lactonase. The QQ activity of A4 and that of Escherichia coli BL21 (DE3) overexpressing AilY could be promoted by Fe2+ , Mn2+ , and Zn2+ while remaining unaffected by other metals tested...

This paper focuses on examining the effects of per capita environmental technology development on the load capacity factor (LCF) within the context of OECD member countries during the period spanning 1990 to 2021. To investigate these relationships, we employ the AMG estimator and FM-LS estimator. Additionally, we explore the validity of the load capacity curve for these countries and estimate the inflection points in the income per capita-environmental sustainability relationship. Our findings lead us to the conclusion that there is no significant impact of environmental technologies on environmental sustainability...

Dye-sensitized solar cell (DSSC) is a photovoltaic device that can be produced from natural source pigments or natural dyes. The selection of natural dyes for DSSC application is currently under research. The utilization of natural dye materials that are easy to obtain, cost-effective, and non-toxic can reduce waste during DSSC fabrication. Natural dyes can be extracted from plants through extraction and chromatography methods. The suitability and viability of utilizing natural dyes as photosensitizers in DSSCs can be predicted using appropriate software simulation by varying related parameters to produce high power conversion efficiency...