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macular degeneration and lifestyle

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https://www.readbyqxmd.com/read/27893849/features-of-age-related-macular-degeneration-in-the-general-adults-and-their-dependency-on-age-sex-and-smoking-results-from-the-german-kora-study
#1
Caroline Brandl, Valentin Breinlich, Klaus J Stark, Sabrina Enzinger, Matthias Aßenmacher, Matthias Olden, Felix Grassmann, Jochen Graw, Margit Heier, Annette Peters, Horst Helbig, Helmut Küchenhoff, Bernhard H F Weber, Iris M Heid
Age-related macular degeneration (AMD) is a vision impairing disease of the central retina characterized by early and late forms in individuals older than 50 years of age. However, there is little knowledge to what extent also younger adults are affected. We have thus set out to estimate the prevalence of early AMD features and late AMD in a general adult population by acquiring color fundus images in 2,840 individuals aged 25 to 74 years of the Cooperative Health Research in the Region of Augsburg project (KORA) in South Germany...
2016: PloS One
https://www.readbyqxmd.com/read/27881145/evaluation-of-efficacy-and-efficiency-of-a-pragmatic-intervention-by-a-social-worker-to-support-informal-caregivers-of-elderly-patients-the-ice-study-study-protocol-for-a-randomized-controlled-trial
#2
Astrid Pozet, Catherine Lejeune, Magalie Bonnet, Sandrine Dabakuyo, Michèle Dion, Philippe Fagnoni, Maryse Gaimard, Geneviève Imbert, Virginie Nerich, Audrey Foubert, Morgane Chotard, Marie Bonin, Amélie Anota, Franck Bonnetain
BACKGROUND: Medical progress and the lifestyle modification have prolonged life expectancy, despite the development of chronic diseases. Support and care for older subjects are often provided by a network of informal caregivers composed of family, friends and neighbors, who are essential in helping older persons to continue living at home. It has been shown that the extent and diversity of informal tasks may jeopardize the physical, mental and social wellbeing of caregivers. METHODS/DESIGN: The aim of the Informal Carers of Elderly cohort is to define, through a longitudinal study, profiles of caregivers of older patients with a diagnosis of one of the following diseases: cancer (breast, prostate, colorectal), neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and similar diseases), neurovascular diseases (stroke), sensory diseases (age-related macular degeneration (AMD)) and heart disease (heart failure)...
November 3, 2016: Trials
https://www.readbyqxmd.com/read/27648680/risk-factors-for-poor-quality-of-life-among-patients-with-age-related-macular-degeneration
#3
Irini Chatziralli, Panagiotis Mitropoulos, Efstratios Parikakis, Dimitrios Niakas, Georgios Labiris
PURPOSE: The purpose of this study was to evaluate the quality of life in patients with age-related macular degeneration (AMD) and compare it with that of healthy controls. Additionally, our study aims to investigate the possible risk factors for poor quality of life in AMD patients. METHODS: Participants in the study were 114 patients with AMD, 63 male and 51 female, mean-aged 76.5 ± 6.1 years. Demographic data, lifestyle factors, and medical history were recorded...
August 10, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27459452/contribution-of-the-nurses-health-study-to-the-epidemiology-of-cataract-age-related-macular-degeneration-and-glaucoma
#4
Jae H Kang, Juan Wu, Eunyoung Cho, Soshiro Ogata, Paul Jacques, Allen Taylor, Chung-Jung Chiu, Janey L Wiggs, Johanna M Seddon, Susan E Hankinson, Debra A Schaumberg, Louis R Pasquale
OBJECTIVES: To review the contribution of the Nurses' Health Study (NHS) to understanding the genetic and lifestyle factors that influence the risk of cataract, age-related macular degeneration, and glaucoma. METHODS: We performed a narrative review of the publications of the NHS between 1976 and 2016. RESULTS: The NHS has helped to elucidate the roles of genetics, lifestyle factors (e.g., cigarette smoking associated with cataract extraction and age-related macular degeneration), medical conditions (e...
September 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27335042/alzheimer-s-disease-and-the-early-signs-of-age-related-macular-degeneration
#5
Shaun Frost, Robyn Guymer, Khin Zaw Aung, S Lance Macaulay, Hamid R Sohrabi, Pierrick Bourgeat, Olivier Salvado, Christopher C Rowe, David Ames, Colin L Masters, Ralph N Martins, Yogesan Kanagasingam, And The Aibl Research Group
This study investigated signs of age related macular degeneration (AMD) in Alzheimer's disease (AD). These age-related diseases primarily affect different parts of the central nervous system but are substantially similar in terms of abnormal extracellular deposits, metabolic and oxidative stress, neuroinflammation and microvascular abnormalities. While AMD is a retinal disease, AD is reported to affect not only the brain but also the retina, with Aβ deposits, neurodegeneration and vascular changes. Large population based studies have provided conflicting results regarding the comorbidity of AD and AMD...
June 2, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27320518/clinical-characteristics-and-risk-factors-of-extensive-macular-atrophy-with-pseudodrusen-the-emap-case-control-national-clinical-trial
#6
Aymeric Douillard, Marie-Christine Picot, Cécile Delcourt, Annie Lacroux, Xavier Zanlonghi, Bernard Puech, Sabine Defoort-Dhelemmes, Isabelle Drumare, Elsa Jozefowicz, Béatrice Bocquet, Corinne Baudoin, Nour Al-Dain Marzouka, Sarah Perez-Roustit, Sophie Arsène, Valérie Gissot, François Devin, Carl Arndt, Benjamin Wolff, Martine Mauget-Faÿsse, Maddalena Quaranta, Thibault Mura, Dominique Deplanque, Hassiba Oubraham, Salomon Yves Cohen, Pierre Gastaud, Olivia Zambrowsky, Catherine Creuzot-Garcher, Saddek Mohand Saïd, Rocio Blanco Garavito, Eric Souied, José-Alain Sahel, Isabelle Audo, Christian Hamel, Isabelle Meunier
PURPOSE: To assess the association of clinical and biological factors with extensive macular atrophy with pseudodrusen (EMAP) characterized by bilateral macular atrophy occurring in patients aged 50 to 60 years and a rapid progression to legal blindness within 5 to 10 years. DESIGN: A national matched case-control study. PARTICIPANTS: Participants were recruited in 10 French Departments of Ophthalmology and their associated clinical investigation centers...
September 2016: Ophthalmology
https://www.readbyqxmd.com/read/27258093/analysis-of-risk-alleles-and-complement-activation-levels-in-familial-and-non-familial-age-related-macular-degeneration
#7
Nicole T M Saksens, Yara T E Lechanteur, Sanne K Verbakel, Joannes M M Groenewoud, Mohamed R Daha, Tina Schick, Sascha Fauser, Camiel J F Boon, Carel B Hoyng, Anneke I den Hollander
AIMS: Age-related macular degeneration (AMD) is a multifactorial disease, in which complement-mediated inflammation plays a pivotal role. A positive family history is an important risk factor for developing AMD. Certain lifestyle factors are shown to be significantly associated with AMD in non-familial cases, but not in familial cases. This study aimed to investigate whether the contribution of common genetic variants and complement activation levels differs between familial and sporadic cases with AMD...
2016: PloS One
https://www.readbyqxmd.com/read/27074381/visual-function-in-older-eyes-in-normal-macular-health-association-with-incident-early-age-related-macular-degeneration-3-years-later
#8
Cynthia Owsley, Mark E Clark, Carrie E Huisingh, Christine A Curcio, Gerald McGwin
PURPOSE: In older eyes in normal macular health, we examined associations between impaired photopic acuity, mesopic acuity, spatial contrast sensitivity, light sensitivity, and the presence of low luminance deficit (difference between photopic and mesopic acuity) at baseline and incident AMD 3 years later. Associations were compared with an association between delayed rod-mediated dark adaptation and incident AMD, previously reported for this cohort. METHODS: Enrollees were 60 years or older...
April 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27071115/vitamin-a-aldehyde-adducts-amd-risk-and-targeted-therapeutics
#9
Janet R Sparrow
Although currently available treatment options for age-related macular degeneration (AMD) are limited, particularly for atrophic AMD, the identification of predisposing genetic variations has informed clinical studies addressing therapeutic options such as complement inhibitors and anti-inflammatory agents. To lower risk of early AMD, recommended lifestyle interventions such as the avoidance of smoking and the intake of low glycemic antioxidant-rich diets have largely followed from the identification of nongenetic modifiable factors...
April 26, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26787681/past-physical-activity-and-age-related-macular-degeneration-the-melbourne-collaborative-cohort-study
#10
Myra B McGuinness, Amalia Karahalios, Julie A Simpson, Robyn H Guymer, Luba D Robman, Allison M Hodge, Ester Cerin, Graham G Giles, Robert P Finger
BACKGROUND/AIMS: To assess the association between past physical activity and early, intermediate and late age-related macular degeneration (AMD) in a community-based cohort study in Melbourne, Australia. METHODS: Diet and lifestyle information was recorded at baseline (1990-1994) and total recreational activity was derived from walking, vigorous and non-vigorous exercise. At follow-up (2003-2007), digital macular photographs were graded for early, intermediate and late AMD...
October 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/26682171/measurement-of-macular-pigment-optical-density-among-healthy-chinese-people-and-patients-with-early-stage-age-related-macular-degeneration
#11
Xue-Tao Ren, Hong Gu, Xu Han, Jun-Yan Zhang, Xue Li, Xiu-Fen Yang, Jun Xu, Torkel Snellingen, Xi-Pu Liu, Ning-Li Wang, Ning-Pu Liu
AIM: To measure the macular pigment optical density (MPOD) in healthy Chinese people and patients with early age-related macular degeneration (AMD). METHODS: Cross-sectional population based study. Demographic and lifestyle characteristics were ascertained by questionnaire. A food frequency questionnaire was completed for all participants. Participants underwent general physical and ophthalmic examinations and MPOD was measured by heterochromatic flicker photometry...
2015: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/26681391/reticular-pseudodrusen-and-their-association-with-age-related-macular-degeneration-the-melbourne-collaborative-cohort-study
#12
Robert P Finger, Elaine Chong, Myra B McGuinness, Luba D Robman, Khin Zaw Aung, Graham Giles, Paul N Baird, Robyn H Guymer
PURPOSE: To determine the prevalence of reticular pseudodrusen (RPD) and its association with age-related macular degeneration (AMD) and AMD risk factors in a large sample. DESIGN: Community-based cohort study in Melbourne, Victoria, Australia. PARTICIPANTS: A total of 21,130 participants 48 to 86 years of age available for ophthalmic assessment at follow-up from 2003 through 2007. METHODS: Lifestyle, diet, and anthropometric measurements were obtained at baseline and follow-up...
March 2016: Ophthalmology
https://www.readbyqxmd.com/read/26466227/influence-of-vegf-c936t-genetic-variant-on-age-related-macular-degeneration
#13
Fernanda Tanaka Iasbeck Gonçalves, Sabrina Mayara Cezario, Maria Clara Jessica Calastri, Camila Ive Ferreira Oliveira, Dorotéia Rossi Silva Souza, Marcela Augusta de Souza Pinhel, Carina Costa Cotrim, Rodrigo Jorge, Rubens Camargo Siqueira
PURPOSE: To evaluate the association between the VEGF-C936T polymorphism and serum vascular endothelial growth factor (VEGF) levels, lifestyle, and demographic parameters in patients with age-related macular degeneration (AMD). METHODS: A total of 183 individuals were enrolled in the present study, including 88 patients with AMD receiving clinical and pharmacological treatment (study group, SG) and 95 individuals without AMD as controls (control group, CG). The presence of the VEGF-C936T polymorphism and serum VEGF levels were determined using polymerase chain reaction/restriction fragment length polymorphism and enzyme-linked immunosorbent assay, respectively...
September 2015: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/26381099/understanding-the-patient-s-lived-experience-of-neovascular-age-related-macular-degeneration-a-qualitative-study
#14
C McCloud, S Lake
PURPOSE: In industrialised populations age-related macular degeneration (ARMD) is the leading cause of visual disability of the elderly. Successful new treatment with anti-endothelial growth factors for neovascular-classified ARMD has led to a divergence in treatment and experiences of people ARMD. This study aimed to understand the participant's experience of neovascular ARMD, including ongoing treatment with anti-vascular endothelial growth factor. METHODS: Twenty-five participants from one clinical site were qualitatively interviewed to elicit their experiences of treatment for neovascular ARMD...
December 2015: Eye
https://www.readbyqxmd.com/read/26354764/joint-associations-of-diet-lifestyle-and%C3%A2-genes-with-age-related-macular%C3%A2-degeneration
#15
Kristin J Meyers, Zhe Liu, Amy E Millen, Sudha K Iyengar, Barbara A Blodi, Elizabeth Johnson, D Max Snodderly, Michael L Klein, Karen M Gehrs, Lesley Tinker, Gloria E Sarto, Jennifer Robinson, Robert B Wallace, Julie A Mares
PURPOSE: Unhealthy lifestyles have been associated with increased odds for age-related macular degeneration (AMD). Whether this association is modified by genetic risk for AMD is unknown and was investigated. DESIGN: Interactions between healthy lifestyles AMD risk genotypes were studied in relation to the prevalence of AMD, assessed 6 years later. PARTICIPANTS: Women 50 to 79 years of age in the Carotenoids in Age-Related Eye Disease Study with exposure and AMD data (n=1663)...
November 2015: Ophthalmology
https://www.readbyqxmd.com/read/26305645/lifestyles-and-cognitive-health-what-older-individuals-can-do-to-optimize-cognitive-outcomes
#16
EDITORIAL
Sudeep S Gill, Dallas P Seitz
No abstract text is available yet for this article.
August 25, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26262695/-nutritional-components-and-macular-degeneration-age-related
#17
Iván Antonio García-Montalvo, Diana Matías-Pérez
OBJECTIVE: nutritional components such as antioxidants may modify the risk of Macular Degeneration Age-related (AMD). This article is a systematic review of published studies relating to the modification of lifestyle, nutrition and vitamin intake to prevent or delay the onset or progression of Macular Degeneration Age-related (AMD). RESULTS: the analysis of the results of research consulted shows that AMD is one of the most common causes of blindness in individuals over 55 years...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/26176222/cross-sectional-and-longitudinal-associations-between-cardiovascular-risk-factors-and-age-related-macular-degeneration-in-the-epic-norfolk-eye-study
#18
Jennifer L Y Yip, Anthony P Khawaja, Michelle P Y Chan, David C Broadway, Tunde Peto, Adnan Tufail, Robert Luben, Shabina Hayat, Amit Bhaniani, Nicholas J Wareham, Kay-Tee Khaw, Paul J Foster
PURPOSE: To examine the cross sectional and longitudinal relationship between cardiovascular risk factors and age-related macular degeneration (AMD) in a large British cohort study. METHODS: The EPIC Norfolk Eye study is nested in a larger prospective cohort study. Data on cardiovascular risk factors were collected at baseline (1993-1997) and follow up (2006-2011) via clinical examination, validated lifestyle questionnaires and serum blood samples. AMD was ascertained using standardised grading of fundus photographs at the follow up...
2015: PloS One
https://www.readbyqxmd.com/read/26149505/-non-pharmacologic-therapy-of-age-related-macular-degeneration-based-on-the-etiopathogenesis-of-the-disease
#19
REVIEW
Tamás Fischer
It has a great therapeutic significance that the disorder of the vascular endothelium, which supplies the affected ocular structures, plays a major role in the development of age-related macular degeneration. Chronic inflammation is closely linked to diseases associated with endothelial dysfuncition and age-related macular degeneration is accompanied by a general inflammatory response. The vascular wall including those in chorioids may be activated by several repeated and/or prolonged mechanical, physical, chemical, microbiological, immunologic and genetic factors causing a protracted host defence response with a consequent vascular damage, which leads to age-related macular degeneration...
July 12, 2015: Orvosi Hetilap
https://www.readbyqxmd.com/read/26049886/reprint-of-survey-of-patients-with-age-related-macular-degeneration-knowledge-and-adherence-to-recommendations
#20
Sanket U Shah, Suman Pilli, David G Telander, Lawrence S Morse, Susanna S Park
OBJECTIVE: To evaluate the patient's understanding of the importance and adherence to the various lifestyle and Age-Related Eye Disease Study (AREDS) supplement recommendations for age-related macular degeneration (AMD). DESIGN: Cross-sectional study. PARTICIPANTS: Patients with AMD treated at the vitreoretinal service clinic. METHODS: Telephone questionnaire survey was administered to assess knowledge and adherence to various recommendations made to patients with AMD about lifestyle and AREDS supplements in this single-institution study...
June 2015: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
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