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https://www.readbyqxmd.com/read/28814886/a-practical-guide-to-the-handling-and-administration-of-talimogene-laherparepvec-in-europe
#1
REVIEW
Kevin J Harrington, Olivier Michielin, Josep Malvehy, Isabella Pezzani Grüter, Lorna Grove, Anna Lisa Frauchiger, Reinhard Dummer
Talimogene laherparepvec is a herpes simplex virus-1-based intralesional oncolytic immunotherapy and is the first oncolytic virus to be approved in Europe. It is indicated for the treatment of adults with unresectable melanoma that is regionally or distantly metastatic (stage IIIB, IIIC, and IVM1a) with no bone, brain, lung, or other visceral disease. Talimogene laherparepvec is a genetically modified viral therapy, and its handling needs special attention due to its deep freeze, cold-chain requirements, its potential for viral shedding, and its administration by direct intralesional injection...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28811074/management-of-multidrug-resistant-gram-negative-bacilli-infections-in-solid-organ-transplant-recipients-set-gesitra-seimc-reipi-recommendations
#2
REVIEW
J M Aguado, J T Silva, M Fernández-Ruiz, E Cordero, J Fortún, C Gudiol, L Martínez-Martínez, E Vidal, L Almenar, B Almirante, R Cantón, J Carratalá, J J Caston, E Cercenado, C Cervera, J M Cisneros, M G Crespo-Leiro, V Cuervas-Mons, J Elizalde-Fernández, M C Fariñas, J Gavaldà, M J Goyanes, B Gutiérrez-Gutiérrez, D Hernández, O Len, R López-Andujar, F López-Medrano, P Martín-Dávila, M Montejo, A Moreno, A Oliver, A Pascual, E Pérez-Nadales, A Román-Broto, R San-Juan, D Serón, A Solé-Jover, M Valerio, P Muñoz, J Torre-Cisneros
Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant (MDR) Gram-negative bacilli (GNB), as they are frequently exposed to antibiotics and the healthcare setting, and are regulary subject to invasive procedures. Nevertheless, no recommendations concerning prevention and treatment are available. A panel of experts revised the available evidence; this document summarizes their recommendations: (1) it is important to characterize the isolate's phenotypic and genotypic resistance profile; (2) overall, donor colonization should not constitute a contraindication to transplantation, although active infected kidney and lung grafts should be avoided; (3) recipient colonization is associated with an increased risk of infection, but is not a contraindication to transplantation; (4) different surgical prophylaxis regimens are not recommended for patients colonized with carbapenem-resistant GNB; (5) timely detection of carriers, contact isolation precautions, hand hygiene compliance and antibiotic control policies are important preventive measures; (6) there is not sufficient data to recommend intestinal decolonization; (7) colonized lung transplant recipients could benefit from prophylactic inhaled antibiotics, specially for Pseudomonas aeruginosa; (8) colonized SOT recipients should receive an empirical treatment which includes active antibiotics, and directed therapy should be adjusted according to susceptibility study results and the severity of the infection...
July 26, 2017: Transplantation Reviews
https://www.readbyqxmd.com/read/28781996/opinion-hazards-faced-by-macromolecules-when-confined-to-thin-aqueous-films
#3
REVIEW
Robert M Glaeser, Bong-Gyoon Han
Samples prepared for single-particle electron cryo-microscopy (cryo-EM) necessarily have a very high surface-to-volume ratio during the short period of time between thinning and vitrification. During this time, there is an obvious risk that macromolecules of interest may adsorb to the air-water interface with a preferred orientation, or that they may even become partially or fully unfolded at the interface. In addition, adsorption of macromolecules to an air-water interface may occur even before thinning. This paper addresses the question whether currently used methods of sample preparation might be improved if one could avoid such interfacial interactions...
2017: Biophysics Reports
https://www.readbyqxmd.com/read/28779880/investigation-of-a-nosocomial-outbreak-of%C3%A2-fungemia-caused-by-candida-pelliculosa-pichia-anomala-in-a-korean-tertiary-care-center
#4
Jiwon Jung, Young Sook Moon, Jung A Yoo, Ji-Hun Lim, Joseph Jeong, Jae-Bum Jun
BACKGROUND: Candida pelliculosa is a rare pathogen of fungemia. There have been a few nosocomial outbreaks of C. pelliculosa fungemia in nurseries and pediatric intensive care units (ICU), hematologic units, and surgical ICU. We describe an epidemiologic outbreak investigation, including case findings of C. pelliculosa fungemia in South Korea. METHODS: This outbreak investigation conducted in a 940-bed, tertiary referral center, Ulsan, South Korea and included active microbial surveillance and a case-control study...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28774285/estimating-the-impact-post-randomization-changes-in-staff-behavior-in-infection-prevention-trials-a-mathematical-modeling-approach
#5
Eric T Lofgren
BACKGROUND: Randomized controlled trials (RCTs) of behavior-based interventions are particularly vulnerable to post-randomization changes between study arms. We assess the impact of such a change in a large, multicenter study of universal contact precautions to prevent infection transmission in intensive care units. METHODS: We construct a stochastic mathematical model of methicillin-resistant Staphylococcus aureus (MRSA) acquisition in a simulated 18-bed intensive care unit (ICU)...
August 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28771457/meningitis-outbreak-caused-by-vaccine-preventable-bacterial-pathogens-northern-ghana-2016
#6
Fortress Y Aku, Fernanda C Lessa, Franklin Asiedu-Bekoe, Phoebe Balagumyetime, Winfred Ofosu, Jennifer Farrar, Mahamoudou Ouattara, Jeni T Vuong, Kofi Issah, Joseph Opare, Sally-Ann Ohene, Charles Okot, Ernest Kenu, Donne K Ameme, David Opare, Abass Abdul-Karim
Bacterial meningitis is a severe, acute infection of the fluid surrounding the brain and spinal cord that can rapidly lead to death. Even with recommended antibiotic treatment, up to 25% of infected persons in Africa might experience neurologic sequelae (1). Three regions in northern Ghana (Upper East, Northern, and Upper West), located in the sub-Saharan "meningitis belt" that extends from Senegal to Ethiopia, experienced periodic outbreaks of meningitis before introduction of serogroup A meningococcal conjugate vaccine (MenAfriVac) in 2012 (2,3)...
August 4, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28768591/hand-hygiene-compliance-in-a-universal-gloving-setting
#7
Noriko Kuruno, Kei Kasahara, Keiichi Mikasa
BACKGROUND: The use of gloves for every patient contact (ie, universal gloving) has been suggested as an infection prevention adjunct and alternative to contact precautions. However, gloves may carry organisms unless they are changed properly. In addition, hand hygiene is required before donning and after removing gloves, and there are scarce data regarding glove changing and hand hygiene in a universal gloving setting. METHODS: This nonrandomized observational before-after study evaluated the effect of education and feedback regarding hand hygiene...
August 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28751036/characteristics-of-methicillin-resistant-staphylococcus-aureus-in-patients-on-admission-to-a-teaching-hospital-in-rio-de-janeiro-brazil
#8
Fernanda Sampaio Cavalcante, Marcos Vinicius Pinheiro, Dennis de Carvalho Ferreira, Celina Vieira da Cunha Guedes Alvarenga, Ana Carolina Fonseca Guimarães, Simone Aranha Nouér, Kátia Regina Netto Dos Santos
BACKGROUND: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are associated with greater mortality and morbidity; however, risk factors for community-acquired infections caused by MRSA have not been established. Therefore, community patients who are admitted to hospitals without the necessary contact precautions and are infected with community-acquired lineages eventually cause these lineages to spread to these settings. The aim of this study was to detect community-acquired lineages of MRSA in patients on admission to a Brazilian teaching hospital...
July 24, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28749890/preventing-enteric-infections-from-contact-with-animals
#9
Betsy Todd
Precautions when visiting petting zoos and state fairs.
August 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28734630/management-of-an-acinetobacter-baumannii-outbreak-in-an-intensive-care-unit
#10
M Tanguy, A Kouatchet, B Tanguy, É Pichard, S Fanello, M-L Joly-Guillou
INTRODUCTION: Acinetobacter baumannii is a ubiquitous pathogen resistant to desiccation and responsible for healthcare-associated infections (HAI), especially in intensive care units (ICU) where it is responsible for 5-10% of HAIs. An A. baumannii outbreak occurred in the ICU of the University Hospital of Angers, France. OBJECTIVES: To describe the A. baumannii outbreak and to evaluate the control measures taken. The secondary objective was to evaluate the impact of the electronic alert system on the incidence of multidrug resistance to antibiotics...
July 19, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28732742/what-do-visitors-know-and-how-do-they-feel-about-contact-precautions
#11
Grace Seibert, Tola Ewers, Anna K Barker, Adam Slavick, Marc-Oliver Wright, Linda Stevens, Nasia Safdar
Patients with Clostridium difficile infection (CDI) are placed in contact precautions. We surveyed 31 visitors of CDI patients to understand their compliance, knowledge, and perceptions of contact precautions. Although most visitors knew where to find the required personal protective equipment, only 42% were fully compliant with gown and gloves. Family members accounted for 90% of visitors, and roughly half of the reasons given for not gowning were related to a lack of perceived risk for family members. Nursing staff are fundamental sources of personal protective equipment (PPE) information for visitors; however, we found variation in staff communication regarding need for visitor PPE use...
July 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28728905/perceptions-of-clostridium-difficile-infections-among-infection-control-professionals-in-taiwan
#12
Yuan-Pin Hung, Jen-Chieh Lee, Hsiao-Ju Lin, Chun-Wei Chiu, Jia-Ling Wu, Hsiao-Chieh Liu, I-Hsiu Huang, Pei-Jane Tsai, Wen-Chien Ko
BACKGROUND: High Clostridium difficile colonization and infection rates among hospitalized patients had been noted in Taiwan. Nevertheless, the cognition about clinical diagnosis and management of CDI among infection control professionals in Taiwan is not clear. MATERIAL AND METHODS: A 24-item survey questionnaire about the diagnosis, therapy, or infection control policies toward CDI was distributed in the annual meeting of the Infectious Disease Society of Taiwan (IDST) in October 2015 and Infectious Control Society of Taiwan (ICST) in April 2016...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28674848/epidemiology-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-an-intensive-care-unit-with-no-single-rooms
#13
Xavier Repessé, Margaux Artiguenave, Sophie Paktoris-Papine, Florence Espinasse, Aurélien Dinh, Cyril Charron, Faten El Sayed, Guillaume Geri, Antoine Vieillard-Baron
BACKGROUND: The transmission of extended-spectrum beta-lactamase-producing enterobacteriaceae (ESBL) is prevented by additional contact precautions, mainly relying on isolation in a single room and hand hygiene. Contact isolation cannot be achieved in our 12-bed ICU, which has only double rooms. We report the epidemiology of ESBL imported, acquired and transmitted in an ICU with no single rooms. METHODS: We prospectively conducted an observational and non-interventional study in a French 12-bed ICU...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28670449/no-nosocomial-transmission-under-standard-hygiene-precautions-in-short-term-contact-patients-in-case-of-an-unexpected-esbl-or-q-a-e-coli-positive-patient-a-one-year-prospective-cohort-study-within-three-regional-hospitals
#14
Dennis Souverein, Sjoerd M Euser, Bjorn L Herpers, Corry Hattink, Patricia Houtman, Amerens Popma, Jan Kluytmans, John W A Rossen, Jeroen W Den Boer
BACKGROUND: Many Highly Resistant Gram Negative Rod (HR-GNR) positive patients are found unexpectedly in clinical cultures, besides patients who are screened and isolated based on risk factors. As unexpected HR-GNR positive patients are isolated after detection, transmission to contact patients possibly occurred. The added value of routine contact tracing in such situations within hospitals with standard hygiene precautions is unknown. METHODS: In 2014, this study was performed as a prospective cohort study...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28654976/contact-precautions-for-endemic-mrsa-and-vre-time-to-retire-legal-mandates
#15
Daniel J Morgan, Richard P Wenzel, Gonzalo Bearman
No abstract text is available yet for this article.
July 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28644499/methods-for-the-detection-and-identification-of-pathogenic-bacteria-past-present-and-future
#16
Linda Váradi, Jia Lin Luo, David E Hibbs, John D Perry, Rosaleen J Anderson, Sylvain Orenga, Paul W Groundwater
In order to retard the rate of development of antibacterial resistance, the causative agent must be identified as rapidly as possible, so that directed patient treatment and/or contact precautions can be initiated. This review highlights the challenges associated with the detection and identification of pathogenic bacteria, by providing an introduction to the techniques currently used, as well as newer techniques that are in development. Focusing on the chemical basis for these techniques, the review also provides a comparison of their advantages and disadvantages...
August 14, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28639449/-optic-properties-of-myopic-correction-by-orthokeratology-contact-lenses-a-case-report
#17
M Mýlková, F Pluháček
INTRODUCTION: Orthokeratology lenses present a special type of hard contact lenses, which is used especially for myopic correction. The lenses are applied during the night, when thanks to their special shape cause temporally (reversible) change of the cornea shape. During the day, there is not necessary to wear any other refractive correction. Due to the wearing regimen, there is, comparing to the classical contact lenses, higher risk of health complications. For their safe use, it is necessary to pay attention to the application of lenses of adequate parameters, follow up the care and hygiene precautions, regular controls and early treatment of possible problems...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28639065/nosocomial-rhinocerebral-mucormycosis-two-cases-with-a-temporal-relationship
#18
Justo Sánchez-Gil, Emilio Guirao-Arrabal, Ginés David Parra-García, María Del Pilar Luzón-García, Maria Fe Bautista-Marín, Matías Barayobre-Barayobre, Andrés Fontalba-Navas
Mucormycosis is an unusual fungal infection that usually affects immunosuppressed patients. Small outbreaks of mucormycosis have been previously reported. We present two clinical cases of fatal rhinocerebral mucormycosis with a close temporal relationship between them and a possible nosocomial transmission: case 1 was a 75-year-old male with diabetes and COPD, treated with antibiotics and systemic corticosteroids, who developed rhinocerebral mucormycosis. Case 2 was an 88-year-old woman who was treated with systemic antibiotics and corticosteroids and developed the same infection after insertion of a nasogastric tube...
June 21, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28617193/are-contact-precautions-ethically-justifiable-in-contemporary-hospital-care
#19
Joanna Harris, Kenneth Walsh, Susan Dodds
Hospital infection control practices known as Contact Precautions are recommended for the management of people with pathogens such as methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococci. BACKGROUND: The patient is isolated, and staff are required to wear gloves, and a gown or apron when providing care. A notice is displayed to remind staff of these requirements and an 'alert' message is placed in the patient's medical record. OBJECTIVE: The aim of this article is to discuss and explore whether practices used in hospitals to reduce the transmission of endemic antibiotic-resistant organisms are ethically justified in today's healthcare environment in the developed world...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28606192/assessment-of-healthcare-worker-protocol-deviations-and-self-contamination-during-personal-protective-equipment-donning-and-doffing
#20
Jennie H Kwon, Carey-Ann D Burnham, Kimberly A Reske, Stephen Y Liang, Tiffany Hink, Meghan A Wallace, Angela Shupe, Sondra Seiler, Candice Cass, Victoria J Fraser, Erik R Dubberke
OBJECTIVE To evaluate healthcare worker (HCW) risk of self-contamination when donning and doffing personal protective equipment (PPE) using fluorescence and MS2 bacteriophage. DESIGN Prospective pilot study. SETTING Tertiary-care hospital. PARTICIPANTS A total of 36 HCWs were included in this study: 18 donned/doffed contact precaution (CP) PPE and 18 donned/doffed Ebola virus disease (EVD) PPE. INTERVENTIONS HCWs donned PPE according to standard protocols. Fluorescent liquid and MS2 bacteriophage were applied to HCWs...
June 13, 2017: Infection Control and Hospital Epidemiology
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