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https://www.readbyqxmd.com/read/28526738/hpv-vaccine-slashes-rates-of-oral-infection
#1
(no author information available yet)
Vaccination against human papillomavirus (HPV) reduces the prevalence of oral infection by an estimated 88% among young adults in the United States, a protection that could help reduce rates of HPV-related oropharyngeal cancers, according to data that will be presented at the American Society of Clinical Oncology Annual Meeting in Chicago, IL. However, the population-level benefit will remain low unless more people get vaccinated.
May 19, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28526331/prevalence-of-oral-human-papillomavirus-by-vaccination-status-among-young-adults-18-30years-old
#2
Jacqueline M Hirth, Mihyun Chang, Vicente A Resto
BACKGROUND: Although there is evidence that human papillomavirus (HPV) vaccination may protect against oral HPV infection, no current research has demonstrated this in the general population. METHODS: We used repeated cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) between 2009 and 2014. Participants 18-30years who indicated whether they had received the HPV vaccine and provided an adequate oral sample were included (N=3040)...
May 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28525447/mothers-fathers-sons-and-human-papillomavirus-immunization-practices
#3
Tami Lynn Thomas, Ora L Strickland, Melinda Higgins
Despite the fact that human papillomavirus (HPV) infection and HPV-related cancers are on the rise in men, male HPV vaccine series completion is less than 10% in many areas. This study examined parental knowledge of the HPV vaccine and intent to vaccinate their sons. A cross-sectional study of 341 parents of boys was conducted in school settings in rural southeastern Georgia. Mothers were 2.07 times more likely than fathers to vaccinate their sons. Future research directions should include strategies to increase HPV vaccination in both genders and focus on parents' perceived severity and vulnerability of their sons to HPV infection...
July 2017: Family & Community Health
https://www.readbyqxmd.com/read/28522585/herpes-simplex-virus-glycoprotein-d-targets-a-specific-dendritic-cell-subset-and-improves-the-performance-of-vaccines-to-human-papillomavirus-associated-tumors
#4
Bruna F M M Porchia, Ana Carolina R Moreno, Rodrigo N Ramos, Mariana O Diniz, Laís Helena T M de Andrade, Daniela S Rosa, José Alexandre M Barbuto, Silvia B Boscardin, Luís Carlos S Ferreira
Cervical cancer is a major public health problem and one of the leading causes of cancer deaths in women. Virtually all cases of cervical cancer, as well as a growing share of anal and head/neck tumors, are associated with human papillomavirus (HPV) infection. Despite the effectiveness, the available prophylactic vaccines do not benefit women with cervical lesions or cancer. Therefore, the search of new immunotherapeutic approaches to treat HPV-induced tumors is still a priority. The present study characterizes a therapeutic antitumor vaccine based on the genetic fusion of the Herpes simplex virus-1 (HSV-1) glycoprotein D (gD) with the E7 oncoprotein from HPV-16 (gDE7)...
May 18, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28520906/maximizing-the-impact-of-human-papillomavirus-hpv-vaccination
#5
Suzanne M Garland, Dorothy A Machalek
No abstract text is available yet for this article.
May 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28520854/declines-in-hpv-associated-high-grade-cervical-lesions-after-introduction-of-hpv-vaccines-in-connecticut-us-2008-2015
#6
Linda M Niccolai, James I Meek, Monica Brackney, James L Hadler, Lynn E Sosa, Daniel M Weinberger
Background: Trends in HPV-associated cervical lesions can provide an indication of vaccine impact. Our purpose was to measure trends in cervical lesions during 2008-2015 and to consider possible explanations including vaccination coverage, changes in screening for cervical cancer, and risk behaviors for acquiring HPV. Methods: Connecticut (CT) implemented mandatory reporting of cervical intraepithelial neoplasia grades 2/3 and adenocarcinoma in situ (CIN2+) in 2008...
May 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28515303/spontaneous-and-vaccine-induced-clearance-of-mus-musculus-papillomavirus-type-1-mmupv1-muspv1-infection
#7
Rosie T Jiang, Joshua W Wang, Shiwen Peng, Tsui-Chin Huang, Chenguang Wang, Fabiana Cannella, Yung-Nien Chang, Raphael P Viscidi, Simon R A Best, Chien-Fu Hung, Richard B S Roden
Mus musculus Papillomavirus1 (MmuPV1/MusPV1) induces persistent papillomas in immunodeficient mice but not common laboratory strains. To facilitate study of immune control, we sought an outbred and immune competent laboratory mouse strain in which persistent papillomas could be established. We found that challenge of SKH1 mice (Crl:SKH1-Hrhr) by scarification on their tail with MmuPV1 resulted in three clinical outcomes: 1) persistent (>2 months) papillomas (∼20%), 2) transient papillomas that spontaneously regress typically within 2 months (∼15%), 3) no visible papillomas and viral clearance (∼65%)...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28515256/opportunities-and-challenges-human-papillomavirus-and-cancer
#8
Christina S Chu, David G Pfister
Mucosal exposure to human papillomavirus (HPV) can lead to anogenital and head and neck (H&N) cancer. Vaccination at a young age can be almost 100% effective in preventing HPV infection with the viral subtypes in both men and women, at least for disease in the anogenital tract. Therapeutic strategies targeting HPV in cervical dysplasia and cancer are showing promise as well in regressing dysplasia and controlling disease. That HPV-positive H&N cancer is a different disease from HPV-negative disease, with different molecular and clinical features and prognosis, is becoming better appreciated...
May 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28512072/lessons-learnt-in-japan-from-adverse-reactions-to-the-hpv-vaccine-a-medical-ethics-perspective
#9
Hirokuni Beppu, Masumi Minaguchi, Kiyoshi Uchide, Kunihiko Kumamoto, Masato Sekiguchi, Yukari Yaju
The human papillomavirus (HPV) vaccine has been linked to a number of serious adverse reactions. The range of symptoms is diverse and they develop in a multi-layered manner over an extended period of time. The argument for the safety and effectiveness of the HPV vaccine overlooks the following flaws: (i) no consideration is given to the genetic basis of autoimmune diseases, and arguments that do not take this into account cannot assure the safety of the vaccine; (ii) the immune evasion mechanisms of HPV, which require the HPV vaccine to maintain an extraordinarily high antibody level for a long period of time for it to be effective, are disregarded; and (iii) the limitations of effectiveness of the vaccine...
April 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28508620/-prevalence-of-human-papillomavirus-in-spanish-women-from-a-population-screening-program
#10
S García, M Dominguez-Gil, J Gayete, S Rojo, J L Muñoz, J S Salas, C Echevarria, M Blanco, C Ramos, M De Frutos, L López-Urrutia, L Viñuela, S Tamames, P Redondo, J M Jiménez, J M Eiros, R Ortiz de Lejarazu
OBJECTIVE: The human papillomavirus (HPV), is necessary to cause a woman developing cervical cancer. The aim of the study was to estimate the prevalence of women with HPV infection, covered by the program of prevention and early detection of cervical cancer of Castile and León (Spain). METHODS: Samples of women included in the screening program were analyzed. Including a total of 120,326 cervical swab samples, collected in the period from January 2012 to December 2014...
May 10, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28506749/minority-college-students-hpv-knowledge-awareness-and-vaccination-history
#11
Sande Gracia Jones, Kayla Mathis-Gamble, Eric A Fenkl
No abstract text is available yet for this article.
April 26, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28506297/cervical-cancer-treatment-costs-and-cost-effectiveness-analysis-of-human-papillomavirus-vaccination-in-vietnam-a-prime-modeling-study
#12
Hoang Van Minh, Nguyen Thi Tuyet My, Mark Jit
BACKGROUND: Cervical cancer is currently the leading cause of cancer mortality among women in South Vietnam and the second leading cause of cancer mortality in North Vietnam. Human papillomavirus (HPV) vaccination has the potential to substantially decrease this burden. The World Health Organization (WHO) recommends that a cost-effectiveness analysis of HPV vaccination is conducted before nationwide introduction. METHODS: The Papillomavirus Rapid Interface for Modeling and Economics (PRIME) model was used to evaluate the cost-effectiveness of HPV vaccine introduction...
May 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28503996/primary-immunization-of-human-papillomavirus-vaccine-in-the-pediatric-population-what-is-the-verdict-now
#13
Aubrey N Jones, Jenna W Bartlett, Rebecca A Bates, Tsz-Yin So
The safety and efficacy of a 2-dose series for the human papillomavirus vaccines rather than a 3-dose series in older children has not been well defined. This article reviews the literature summarizing the use of all 3 HPV vaccines (2vHPV, 4vHPV, 9vHPV) as a 2-dose series for females and 4vHPV and 9vHPV for males younger than 15 years. Six prospective trials evaluating immunogenicity of a 2-dose series of 2vHPV and/or 4vHPV, as well as an ongoing prospective clinical trial for 9vHPV, are discussed. The 2-dose series with Gardasil 9(®) in both males and females ages 9 to 14 years appears to be the most widely accepted recommendation...
June 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28499554/effectiveness-of-hpv-vaccines-against-genital-warts-in-women-from-valencia-spain
#14
Esther Navarro-Illana, Mónica López-Lacort, Pedro Navarro-Illana, Juan José Vilata, Javier Diez-Domingo
OBJECTIVES: To assess the effectiveness of the HPV vaccines in preventing genital warts in young women. DESIGN: Population-based study using health databases. SETTING: Valencian Community (Spain). PARTICIPANTS: All girls and women aged 14-19years who were registered in the Valencian Community between January 2009 and December 2014 (n=279,787). MAIN OUTCOME MEASURES: Incident cases of genital warts were defined as the first activation of diagnosis code ICD-9-CM 078...
June 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28499288/impact-of-number-of-human-papillomavirus-vaccine-doses-on-genital-warts-diagnoses-among-a-national-cohort-of-u-s-adolescents
#15
Rebecca B Perkins, Mengyun Lin, Sherrie F Wallington, Amresh Hanchate
BACKGROUND: The impact of fewer than 3 doses of human papillomavirus (HPV) vaccine on genital warts is uncertain. METHODS: Using the Truven Health Analytics Marketscan administrative database, we compared rates of genital warts among women receiving 0, 1, 2, or 3 doses of HPV vaccine. Females aged 9 to 18 years on January 1, 2007, who were continuously enrolled in the database through December 31, 2013, were included. Patients were assigned an HPV dose state (0, 1, 2, or 3) based on the last recorded dose...
June 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28497715/health-maintenance-deficits-in-a-fully-insured-population-of-adolescents-with-chronic-medical-conditions
#16
Rebecca Sainato, Michelle Flores, Allison Malloy, Casey Geaney, Michael Rajnik, Martin Ottolini, Martin Weisse
The current national monitoring of routine wellness care and vaccine uptake does not provide data on health maintenance among pediatric populations with chronic medical conditions. In this case-control study that analyzes wellness visits and vaccine uptake among adolescents, ages 16 to 18 years, we identified 938 without (controls) and 74 with (cases) 1 of 12 specific chronic medical conditions. The PPSV23 (23-valent pneumococcal polysaccharide vaccine) is recommended by the Advisory Committee on Immunization Practices for these 12 conditions and served as a measure of uptake for medically indicated vaccines...
June 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28494533/awareness-of-and-attitudes-toward-human-papillomavirus-vaccination-among-adults-in-korea-9-year-changes-in-nationwide-surveys
#17
Jin-Kyoung Oh, Bo Yoon Jeong, E Hwa Yun, Min Kyung Lim
Purpose: Human papillomavirus (HPV) vaccination has been included in the National Immunization Program in Korea since 2016. We aimed to evaluate changes in the awareness of and attitudes toward HPV vaccination, among adults in Korea since the first introduction of the vaccines in 2007. Materials and Methods: A nationwide population-based survey was conducted in 2016 for 1200 nationally representative Korean men and women; the data obtained were compared with the data from the nationwide survey conducted in 2007...
May 10, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28492781/evaluation-of-knowledge-about-the-human-papilloma-virus-hpv-and-its-vaccination-among-community-health-agents-in-the-municipality-of-tubar%C3%A3-o-santa-catarina-brazil-in-2014
#18
André Luciano Manoel, Andreia Bittencourt Rodrigues, Elisa Zanatta Piva, Thainá Paola Warpechowski, Fabiana Schuelter-Trevisol
OBJECTIVE: to evaluate the knowledge of Community Health Agents (CHA) about the Human Papilloma Virus (HPV) and its vaccination. METHODS: this is a cross-sectional study with CHA who worked in Tubarão-SC, Brazil, in 2014; data were collected through an evaluation tool about HPV and its vaccination, validated for English language and translated and adapted into Portuguese. RESULTS: 124 CHA participated in this study; all of them had already heard about HPV, but only 25...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28492521/coinjection-of-il2-dna-enhances-e7-specific-antitumor-immunity-elicited-by-intravaginal-therapeutic-hpv-dna-vaccination-with-electroporation
#19
Y Sun, S Peng, A Yang, E Farmer, T-C Wu, Chien-Fu Hung
The generation and use of therapeutic human papillomavirus (HPV) DNA vaccines represent an appealing treatment method against HPV-associated cervical cancer due to their safety and durability. Previously, we created a therapeutic HPV DNA vaccine candidate by linking the HPV16-E7 DNA sequence to calreticulin (CRT/E7), which we showed could generate significant E7-specific cytotoxic T lymphocyte (CTL)-mediated anti-tumor immune responses against HPV16 oncogenes expressing murine tumor model TC-1. Here we assess the therapeutic efficacy of intravaginal immunization with pcDNA3-CRT/E7 followed by electroporation...
May 11, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28490581/patterns-of-prevalent-hpv-and-sti-co-infections-and-associated-factors-among-hiv-negative-young-western-cape-south-african-women-the-evri-trial
#20
Lynette J Menezes, Ubin Pokharel, Staci L Sudenga, Matthys H Botha, Michele Zeier, Martha E Abrahamsen, Richard H Glashoff, Susan Engelbrecht, Maarten F Schim van der Loeff, Louvina E van der Laan, Siegfried Kipping, Douglas Taylor, Anna R Giuliano
OBJECTIVE: To estimate the prevalence and describe the patterns of concurrent human papillomavirus (HPV) and STIs and associated factors among HIV-negative young Western Cape, South African women participating in the Efficacy of HPV Vaccine to Reduce HIV Infection (EVRI) trial. METHODS: HIV-negative women aged 16-24 years old were enrolled in the EVRI trial (NCT01489527) and randomised to receive the licensed four-valent HPV vaccine or placebo. At study entry, participants were clinically evaluated for five STIs: herpes simplex virus type 2 (HSV-2), chlamydia, gonorrhoea, syphilis and disease-causing HPV genotypes (6/11/16/18/31/33/35/39/45/51/52/56/58/59/68)...
May 10, 2017: Sexually Transmitted Infections
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