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https://www.readbyqxmd.com/read/29036336/missed-opportunities-for-human-papillomavirus-vaccine-initiation-in-an-insured-adolescent-female-population
#1
Claudia M Espinosa, Gary S Marshall, Charles R Woods, Qianli Ma, Derek Ems, Irene Nsiah, Laura E Happe, Michael J Smith
Background: This study assessed the initiation of HPV vaccination in insured adolescent females in relation to physician visits and receipt of other vaccines routinely given at the same age. Methods: January 1, 2010, and September 31, 2015. Vaccination administration was determined by using Current Procedural Terminology codes. A missed opportunity was defined as the absence of an HPV vaccine at the following encounter types: visits with a 4-valent meningococcal conjugate vaccine (MenACWY) or tetanus, diphtheria, and acellular pertussis (Tdap) vaccine claim; well adolescent visits; or any encounter with a primary care provider (PCP)...
September 23, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29035332/random-network-models-to-predict-the-long-term-impact-of-hpv-vaccination-on-genital-warts
#2
Javier Díez-Domingo, Víctor Sánchez-Alonso, Rafael-J Villanueva, Luis Acedo, José-Antonio Moraño, Javier Villanueva-Oller
The Human papillomaviruses (HPV) vaccine induces a herd immunity effect in genital warts when a large number of the population is vaccinated. This aspect should be taken into account when devising new vaccine strategies, like vaccination at older ages or male vaccination. Therefore, it is important to develop mathematical models with good predictive capacities. We devised a sexual contact network that was calibrated to simulate the Spanish epidemiology of different HPV genotypes. Through this model, we simulated the scenario that occurred in Australia in 2007, where 12-13 year-old girls were vaccinated with a three-dose schedule of a vaccine containing genotypes 6 and 11, which protect against genital warts, and also a catch-up program in women up to 26 years of age...
October 16, 2017: Viruses
https://www.readbyqxmd.com/read/29035163/uptake-and-correlates-of-cervical-cancer-screening-among-hiv-infected-women-attending-hiv-care-in-uganda
#3
Rhoda K Wanyenze, John Baptist Bwanika, Jolly Beyeza-Kashesya, Shaban Mugerwa, Jim Arinaitwe, Joseph K B Matovu, Violet Gwokyalya, Dickson Kasozi, Justine Bukenya, Fred Makumbi
BACKGROUND: Human immunodeficiency virus (HIV)-infected women are at high risk of cervical cancer. OBJECTIVE: This study assessed uptake and correlates of cervical screening among HIV-infected women in care in Uganda. METHODS: A nationally representative cross-sectional survey of HIV-infected women in care was conducted from August to November 2016. Structured interviews were conducted with 5198 women aged 15-49 years, from 245 HIV clinics...
2017: Global Health Action
https://www.readbyqxmd.com/read/29033936/coinhibitory-receptor-expression-and-immune-checkpoint-blockade-maintaining-a-balance-in-cd8-t-cell-responses-to-chronic-viral-infections-and-cancer
#4
REVIEW
Isobel S Okoye, Michael Houghton, Lorne Tyrrell, Khaled Barakat, Shokrollah Elahi
In cancer and chronic viral infections, T cells are exposed to persistent antigen stimulation. This results in expression of multiple inhibitory receptors also called "immune checkpoints" by T cells. Although these inhibitory receptors under normal conditions maintain self-tolerance and prevent immunopathology, their sustained expression deteriorates T cell function: a phenomenon called exhaustion. Recent advances in cancer immunotherapy involve blockade of cytotoxic T lymphocyte antigen-4 and programmed cell death 1 in order to reverse T cell exhaustion and reinvigorate immunity, which has translated to dramatic clinical remission in many cases of metastatic melanoma and lung cancer...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29031503/assessing-dentists-human-papillomavirus-related-health-literacy-for-oropharyngeal-cancer-prevention
#5
Coralia Vázquez-Otero, Cheryl A Vamos, Erika L Thompson, Laura K Merrell, Stacey B Griner, Nolan S Kline, Frank A Catalanotto, Anna R Giuliano, Ellen M Daley
BACKGROUND: Oropharyngeal cancers related to human papillomavirus (HPV) are on the rise. Dentists may be the next group of providers participating in the prevention of HPV. The aim of this study was to assess dentists' health literacy regarding the connection of HPV and oropharyngeal cancer. METHODS: The authors conducted 4 focus groups with dentists (N = 33) during a regional dental conference in 2016. Guided by the health literacy competencies (that is, access, understand, appraise, and apply), the authors used constant comparison methods for data analysis...
October 12, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29031425/contents-of-japanese-pro-and-anti-hpv-vaccination-websites-a-text-mining-analysis
#6
Tsuyoshi Okuhara, Hirono Ishikawa, Masahumi Okada, Mio Kato, Takahiro Kiuchi
OBJECTIVE: In Japan, the human papillomavirus (HPV) vaccination rate has sharply fallen to nearly 0% due to sensational media reports of adverse events. Online anti-HPV-vaccination activists often warn readers of the vaccine's dangers. Here, we aimed to examine frequently appearing contents on pro- and anti-HPV vaccination websites. METHODS: We conducted online searches via two major search engines (Google Japan and Yahoo! Japan). Targeted websites were classified as "pro," "anti," or "neutral" according to their claims, with the author(s) classified as "health professionals," "mass media," or "laypersons...
September 23, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29030149/clinical-management-of-women-presenting-with-field-effect-of-hpv-and-intraepithelial-disease
#7
REVIEW
T S Adams, N H Mbatani
Anogenital human papillomavirus is the most common sexually transmitted infection acquired through skin-to-skin contact. Most infections are cleared by an intact immune system. Persistence of these infections results in precancerous lesions and, eventually, to cancers of the cervix, vagina, vulva, and perianal area. The introduction of the prophylactic human papilloma virus (HPV) vaccinations may reduce the incidence of these infections, but the effect of these vaccinations will be seen only in the decades that follow...
September 6, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29029645/on-the-implications-of-desexualizing-vaccines-against-sexually-transmitted-diseases-reflections-from-a-practicing-pediatrician
#8
Amanda F Dempsey
Human papillomavirus (HPV) vaccination holds great promise for drastically reducing the incidence of HPV-associated cancers of the genital tract, and possibly also certain head and neck cancers. Unfortunately, rates of HPV vaccine utilization among adolescents are low in many countries. Many research studies have identified the fact that HPV is a sexually transmitted infection as a barrier to higher vaccination rates. This is related to providers' and parents' reluctance to discuss or consider the burgeoning sexuality of their child...
October 13, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29028565/human-papillomavirus-vaccine-initiation-in-asian-indians-and-asian-subpopulations-a-case-for-examining-disaggregated-data-in-public-health-research
#9
H Budhwani, P De
OBJECTIVES: Vaccine disparities research often focuses on differences between the five main racial and ethnic classifications, ignoring heterogeneity of subpopulations. Considering this knowledge gap, we examined human papillomavirus (HPV) vaccine initiation in Asian Indians and Asian subpopulations. STUDY DESIGN: National Health Interview Survey data (2008-2013), collected by the National Center for Health Statistics, were analyzed. METHODS: Multiple logistic regression analysis was conducted on adults aged 18-26 years (n = 20,040)...
October 10, 2017: Public Health
https://www.readbyqxmd.com/read/29028414/immunization-attitudes-and-practices-among-family-medicine-providers
#10
Cynthia A Bonville, Joseph B Domachowske, Donald A Cibula, Manika Suryadevara
OBJECTIVE: To describe immunization attitudes and practices among family medicine providers across New York State. METHODS: In this cross-sectional survey study, family medicine providers across New York State completed a questionnaire to assess vaccine beliefs and barriers and immunization practices. STATISTICAL ANALYSIS: Descriptive statistical methods were used to define provider characteristics, knowledge and vaccine practices. RESULTS: Completed questionnaires from 226 family medicine providers were included for analysis...
October 13, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29027811/prevention-of-human-papillomavirus-hpv-related-tumors-in-people-living-with-human-immunodeficiency-virus-hiv
#11
Mario Poljak, Anja Šterbenc, Maja M Lunar
In comparison to their HIV-negative counterparts, people living with HIV (PLWH) have a higher prevalence of human papillomavirus (HPV) infection in various anatomical sites coupled with increased HPV persistence, higher risk of HPV-related tumors, and faster disease progression. Areas covered: Gender-neutral prevention strategies for HPV-related cancers in PLWH discussed: ABC approach, HPV vaccination, antiretroviral treatment (ART), anal cancer screening, and smoking cessation. Gender specific strategies: cervical cancer screening reduces the incidence and mortality of cervical cancer and circumcision might reduce the risk of HPV infections in men...
October 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29025844/investigating-canadian-parents-hpv-vaccine-knowledge-attitudes-and-behaviour-a-study-protocol-for-a-longitudinal-national-online-survey
#12
Gilla K Shapiro, Samara Perez, Anila Naz, Ovidiu Tatar, Juliet R Guichon, Rhonda Amsel, Gregory D Zimet, Zeev Rosberger
INTRODUCTION: Human papillomavirus (HPV), a sexually transmitted infection, can cause anogenital warts and a number of cancers. To prevent morbidity and mortality, three vaccines have been licensed and are recommended by Canada's National Advisory Committee on Immunisation (for girls since 2007 and boys since 2012). Nevertheless, HPV vaccine coverage in Canada remains suboptimal in many regions. This study will be the first to concurrently examine the correlates of HPV vaccine decision-making in parents of school-aged girls and boys and evaluate changes in parental knowledge, attitudes and behaviours over time...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025500/the-influence-of-self-efficacy-in-medical-drama-television-programming-on-behaviors-and-emotions-that-promote-cervical-cancer-prevention
#13
Sungsu Kim, Jay D Hmielowski
OBJECTIVES: We explored the influences of medical drama viewing on health behaviors and emotions, and examined the role of self-efficacy in medical drama programming. METHODS: A single-factor, 2-condition experimental design that manipulated self-efficacy levels was adopted. A total of 131 female undergraduate students who were likely involved with the issues of HPV vaccination and cervical cancer participated in this experiment. RESULTS: In line with social cognitive theory, the results indicated that participants in the high self-efficacy condition showed greater behavioral intention to receive a Pap smear (F (1, 126) = 4...
November 1, 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29023748/what-cervical-screening-is-appropriate-for-women-who-have-been-vaccinated-against-high-risk-hpv-a-simulation-study
#14
Rebecca Landy, Peter Windridge, Matthew S Gillman, Peter D Sasieni
Women vaccinated against HPV16/18 are approaching the age for cervical screening, however an updated screening algorithm has not been agreed. We use a microsimulation model calibrated to real published data to determine the appropriate screening intensity for vaccinated women. Natural histories in the absence of vaccination were simulated for 300,000 women using 10,000 sets of transition probabilities. Vaccination with i) 100% efficacy against HPV16/18, ii) 15% cross-protection, iii) waning vaccine efficacy, and iv) 100% efficacy against HPV16/18/31/33/45/52/58 was added, as were a range of screening scenarios appropriate to the UK...
October 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29023157/public-health-and-school-nurses-perceptions-of-barriers-to-hpv-vaccination-in-missouri
#15
Darson Rhodes, Joseph Visker, Carol Cox, Emily Forsyth, Kendra Woolman
Human Papilloma Virus (HPV) is associated with various forms of cancer and is preventable with vaccination. Nurses are in a unique position to directly influence a person's decision to receive the HPV vaccine. A statewide sample of both school and public health nurses was used to assess knowledge and attitudes related to the HPV vaccine as well as nurse's behaviors and behavioral intentions toward educating parents and recommending the vaccine. Positive attitudes and adequate knowledge levels were found, however, the majority of school nurses did not provide information and resources to parents...
October 2017: Journal of Community Health Nursing
https://www.readbyqxmd.com/read/29021405/high-prevalence-of-high-risk-hpv-genotypes-other-than-16-and-18-in-cervical-cancers-of-cura%C3%A3-ao-implications-for-choice-of-prophylactic-hpv-vaccine
#16
Desiree J Hooi, Birgit I Lissenberg-Witte, Maurits N C de Koning, Herbert M Pinedo, Gemma G Kenter, Chris J L M Meijer, Wim G Quint
BACKGROUND: Curaçao is a Dutch-Caribbean Island located in a high-risk area for cervical cancer.Prior to introduction of a prophylactic human papillomavirus (HPV) vaccine, knowledge of the prevalence of high-risk HPV vaccine genotypes (HPV16, 18, 31, 33, 45, 52 and 58) in cervical (pre)cancer is required. OBJECTIVE: To investigate the prevalence of HPV genotypes in invasive cervical cancers (ICC) and cervical intraepithelial neoplasia (CIN) grade 1, 2 and 3 in Curaçao...
October 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29017279/population-level-herd-protection-of-males-from-a-female-human-papillomavirus-vaccination-program-evidence-from-australian-serosurveillance
#17
Alexis J Pillsbury, Helen E Quinn, TaNisha D Evans, Peter B McIntyre, Julia M L Brotherton
Background: Australia instituted funded female human papillomavirus (HPV) immunization in 2007, followed by a targeted male vaccination program in 2013. To date, Australia is one of only several countries with a funded male HPV immunization program. In 2012-2013, we conducted a survey of HPV seroprevalence in males to assess whether or not a herd impact of female vaccination could be observed. Methods: We conducted a cross-sectional study of de-identified residual diagnostic test serum samples from males aged 15-39 years from laboratories in 3 Australian states and calculated the proportion seropositive to HPV types 6, 11, 16, and 18...
September 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016596/experiences-of-operational-costs-of-hpv-vaccine-delivery-strategies-in-gavi-supported-demonstration-projects
#18
Siobhan Botwright, Taylor Holroyd, Shreya Nanda, Paul Bloem, Ulla K Griffiths, Anissa Sidibe, Raymond C W Hutubessy
From 2012 to 2016, Gavi, the Vaccine Alliance, provided support for countries to conduct small-scale demonstration projects for the introduction of the human papillomavirus vaccine, with the aim of determining which human papillomavirus vaccine delivery strategies might be effective and sustainable upon national scale-up. This study reports on the operational costs and cost determinants of different vaccination delivery strategies within these projects across twelve countries using a standardized micro-costing tool...
2017: PloS One
https://www.readbyqxmd.com/read/28994707/why-human-papillomavirus-acute-infections-matter
#19
REVIEW
Samuel Alizon, Carmen Lía Murall, Ignacio G Bravo
Most infections by human papillomaviruses (HPVs) are `acute', that is non-persistent. Yet, for HPVs, as for many other oncoviruses, there is a striking gap between our detailed understanding of chronic infections and our limited data on the early stages of infection. Here we argue that studying HPV acute infections is necessary and timely. Focusing on early interactions will help explain why certain infections are cleared while others become chronic or latent. From a molecular perspective, descriptions of immune effectors and pro-inflammatory pathways during the initial stages of infections have the potential to lead to novel treatments or to improved handling algorithms...
October 10, 2017: Viruses
https://www.readbyqxmd.com/read/28993170/college-women-hpv-genotyping-and-sexual-behavior-before-hpv-vaccination-results-from-samples-stored-for-a-long-time
#20
Antonia Herrera-Ortiz, Carlos Jesús Conde-Glez, Ma Leonidez Olamendi-Portugal, Santa García-Cisneros, Tanya Plett-Torres, Miguel A Sánchez-Alemán
HPV is the sexually transmitted agent most common among young people, like college students. The aim of study was to associate sexual behavior characteristics of women with HPV, detected in genital samples taken before the introduction of the HPV vaccine. Female students during 2001-2005 donated genital samples and the samples were re-analyzed in 2013 for HPV genotyping by RT-PCR. The frozen storage of the students' genital samples allowed the detection of HPV DNA and its genotyping after years of sample collection...
October 6, 2017: Journal of Infection and Public Health
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