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https://www.readbyqxmd.com/read/28223433/global-cancer-in-women-burden-and-trends
#1
Lindsey A Torre, Farhad Islami, Rebecca L Siegel, Elizabeth M Ward, Ahmedin Jemal
There are striking disparities in the global cancer burden in women, yet few publications highlight cancer occurrence in this population, particularly for cancers that are not sex-specific. This paper, the first in a series of two, summarizes the current burden, trends, risk factors, prevention, early detection, and survivorship of all cancers combined and seven sites (breast, cervix, uterine corpus, ovary, colorectum, lung, and liver) that account for about 60% of the cancer burden among women worldwide, using data from the International Agency for Research on Cancer...
February 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28222722/a-longitudinal-study-on-determinants-of-hpv-vaccination-uptake-in-parents-guardians-from-different-ethnic-backgrounds-in-amsterdam-the-netherlands
#2
Catharina J Alberts, Maarten F Schim van der Loeff, Yvonne Hazeveld, Hester E de Melker, Marcel F van der Wal, Astrid Nielen, Fatima El Fakiri, Maria Prins, Theo G W M Paulussen
BACKGROUND: Human papillomavirus (HPV) vaccination coverage in the Netherlands is low (~60%) compared to other childhood vaccinations (>90%), and even lower among ethnic minorities. The aim of this study was to explore the possible impact of ethnicity on the determinants of both HPV vaccination intention and HPV vaccination uptake among parents/guardians having a daughter that is invited for the HPV vaccination. METHODS: In February 2014, parents/guardians living in Amsterdam were invited to complete a questionnaire about social-psychological determinants of their decision making process regarding the HPV vaccination of their daughter and socio-demographic characteristics...
February 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28220313/hiv-infected-young-men-demonstrate-appropriate-risk-perceptions-and-beliefs-about-safer-sexual-behaviors-after-human-papillomavirus-vaccination
#3
Jessica A Kahn, Jeannette Lee, Marvin Belzer, Joel M Palefsky
The aim of this study was to identify risk perceptions after human papillomavirus (HPV) vaccination among HIV-infected young men who have sex with men. On average, participants appropriately perceived themselves to be at lower than neutral risk for HPV (mean subscale score 4.2/10), at higher than neutral risk for other sexually transmitted infections (7.0/10), and that safer sexual behaviors were still important (8.5/10). Higher perceived risk of HPV was associated with African-American race (p = .03); higher perceived risk of other sexually transmitted infections with White race (p = ...
February 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28216554/harnessing-nanoparticles-for-immunomodulation-and-vaccines
#4
REVIEW
Ariane C Gomes, Mona Mohsen, Martin F Bachmann
The first successful use of nanoparticles (NPs) for vaccination was reported almost 40 years ago with a virus-like particle-based vaccine against Hepatitis B. Since then, the term NP has been expanded to accommodate a large number of novel nano-sized particles engineered from a range of materials. The great interest in NPs is likely not only a result of the two successful vaccines against hepatitis B and Human Papilloma Virus (HPV) that use this technology, but also due to the versatility of those small-sized particles, as indicated by the wide range of applications reported so far, ranging from medicinal and cosmetics to purely technical applications...
February 14, 2017: Vaccines
https://www.readbyqxmd.com/read/28215050/racial-disparities-in-preventable-risk-factors-for-head-and-neck-cancer
#5
Sunshine Dwojak, Neil Bhattacharyya
OBJECTIVES/HYPOTHESIS: To demonstrate racial differences in preventable risk behaviors/practices that contribute to head and neck cancer (HNCA). STUDY DESIGN: Cross-sectional analysis of large national risk factor survey. METHODS: The Behavioral Risk Factor Surveillance System for 2013 was analyzed. Demographic data were extracted, including age, sex, and race. Social habits considered risk factors for HNCA were also extracted, including alcohol consumption, smoking, and human papillomavirus (HPV) vaccination status...
February 19, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28214188/prevalence-of-human-papillomavirus-infection-among-71-435-women-in-jiangxi-province-china
#6
Tian-Yu Zhong, Ji-Chun Zhou, Rong Hu, Xiao-Na Fan, Xiao-Ying Xie, Zhao-Xia Liu, Min Lin, Yi-Guo Chen, Xiao-Mei Hu, Wei-Hua Wang, Long Li, Hua-Ping Xiao
Cervical cancer is the third most common cancer in women worldwide. Human papillomavirus (HPV) has been identified as an etiological factor for cervical cancer. Data on the prevalence and subtype distribution of HPV infection in Jiangxi Province are incomplete. In this study, we investigated HPV subtype distribution and prevalence in Jiangxi Province between August 1, 2010, and December 31, 2015. A total of 71,435 individuals ranging in age from 16 to 77 years were recruited. Cervicovaginal swabs were collected from each participant, and HPV screening was performed...
February 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28213874/disease-burden-of-human-papillomavirus-infection-in-the-netherlands-1989-2014-the-gap-between-females-and-males-is-diminishing
#7
Scott A McDonald, Venetia Qendri, Johannes Berkhof, Hester E de Melker, Johannes A Bogaards
PURPOSE: Besides cervical cancer, HPV infection is linked to a multitude of diseases in both males and females, suggesting that vaccination programmes should be re-evaluated, with a judicious assessment made of the disease burden stratified by sex, age, and genotype. Projections of burden into the near future are also needed to provide a benchmark for evaluating the impact of vaccination programmes, and to assess the need for scaling-up preventive measures. METHODS: Using the disability-adjusted life-years (DALY) measure, we estimated the total HPV-associated disease burden in the Netherlands...
February 17, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28212457/papillomaviruses-a-systematic-review
#8
Rodrigo Pinheiro Araldi, Suely Muro Reis Assaf, Rodrigo Franco de Carvalho, Márcio Augusto Caldas Rocha de Carvalho, Jacqueline Mazzuchelli de Souza, Roberta Fiusa Magnelli, Diego Grando Módolo, Franco Peppino Roperto, Rita de Cassia Stocco, Willy Beçak
In the last decades, a group of viruses has received great attention due to its relationship with cancer development and its wide distribution throughout the vertebrates: the papillomaviruses. In this article, we aim to review some of the most relevant reports concerning the use of bovines as an experimental model for studies related to papillomaviruses. Moreover, the obtained data contributes to the development of strategies against the clinical consequences of bovine papillomaviruses (BPV) that have led to drastic hazards to the herds...
February 16, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28209248/communication-technologies-to-improve-hpv-vaccination-initiation-and-completion-a-systematic-review
#9
REVIEW
Diane B Francis, Joan R Cates, Kyla P Garrett Wagner, Tracey Zola, Jenny E Fitter, Tamera Coyne-Beasley
OBJECTIVES: This systematic review examines the effectiveness of communication technology interventions on HPV vaccination initiation and completion. METHODS: A comprehensive search strategy was used to identify existing randomized controlled trials testing the impact of computer-, mobile- or internet-based interventions on receipt of any dose of the HPV vaccine. Twelve relevant studies were identified with a total of 38,945 participants. RESULTS: The interventions were delivered using several different methods, including electronic health record (i...
February 6, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28207677/predictors-of-human-papillomavirus-vaccine-initiation-and-completion-among-latino-mothers-of-11-to-17-year-old-daughters-living-along-the-texas-mexico-border
#10
Daisy Y Morales-Campos, Deborah Parra-Medina
Few Texas Latino girls initiate and complete the human papillomavirus (HPV) vaccine series, but few studies have examined predictors of initiation and completion in this group. Mothers are crucial to vaccine uptake. Using self-reported data from mothers of unvaccinated girls (n = 317), we examined the association between predictors (HPV and HPV vaccine knowledge, vaccine self-efficacy) and outcomes (initiation and completion). Despite an increase in HPV and HPV vaccine knowledge from baseline to follow-up (n = 195), we found no association between the predictors and the outcomes...
April 2017: Family & Community Health
https://www.readbyqxmd.com/read/28196849/a-population-based-study-of-sociodemographic-and-geographic-variation-in-hpv-vaccination
#11
Lila J Finney Rutten, Patrick M Wilson, Debra J Jacobson, Amenah A Agunwamba, Carmen Radecki Breitkopf, Robert M Jacobson, Jennifer L St Sauver
BACKGROUND: HPV vaccination rates in the U.S. remain low and lag behind other recommended adolescent vaccines. Studies evaluating the association of geographic and area-level characteristics with HPV vaccination rates provide a valuable resource for public health planning. METHOD: We used the Rochester Epidemiology Project data linkage system to ascertain HPV vaccination rates between 2010 and 2015 in a 7-county region of southern MN. Geocoded individual patient data was spatially linked to socioeconomic data from the American Community Survey at the census block group level...
February 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28196735/gtl001-and-bivalent-cyaa-based-therapeutic-vaccine-strategies-against-human-papillomavirus-and-other-tumor-associated-antigens-induce-effector-and-memory-t-cell-responses-that-inhibit-tumor-growth
#12
Michaël Esquerré, Marie Momot, Anne Goubier, Christophe Gonindard, Stéphane Leung-Theung-Long, Yolande Misseri, Marie-Christine Bissery
GTL001 is a bivalent therapeutic vaccine containing human papillomavirus (HPV) 16 and HPV18 E7 proteins inserted in the Bordetella pertussis adenylate cyclase (CyaA) vector intended to prevent cervical cancer in HPV-infected women with normal cervical cytology or mild abnormalities. To be effective, therapeutic cervical cancer vaccines should induce both a T cell-mediated effector response against HPV-infected cells and a robust CD8(+) T-cell memory response to prevent potential later infection. We examined the ability of GTL001 and related bivalent CyaA-based vaccines to induce, in parallel, effector and memory CD8(+) T-cell responses to both vaccine antigens...
February 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28196673/mean-direct-medical-care-costs-associated-with-cervical-cancer-for-commercially-insured-patients-in-texas
#13
David R Lairson, Shuangshuang Fu, Wenyaw Chan, Li Xu, Zeena Shelal, Lois Ramondetta
OBJECTIVE: To determine the mean cervical cancer medical care costs for patients enrolled in commercial insurance in Texas. Cost is represented by insurer and patient payments for care. METHODS: We estimated the mean medical care costs during the first 2years after the index diagnosis date for patients with cervical cancer (cases). Cases were identified using claims-based International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9), diagnosis codes and matched to controls without a claims-based ICD-9 code for cancer using a 2-step propensity score matching method...
February 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28196178/association-of-human-papillomavirus-vaccine-with-the-development-of-keratinocyte-carcinomas
#14
Anna J Nichols, Amber Heyna Allen, Shahjahan Shareef, Evangelos V Badiavas, Robert S Kirsner, Tim Ioannides
Importance: Keratinocyte carcinomas (KCs), consisting of squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs), are the most common human malignant neoplasms. Several risk factors have been implicated in KC development. For some SCCs, particularly those in immunocompromised patients, human papillomavirus (HPV) may be an important factor. Objective: To determine whether quadrivalent HPV vaccination would affect the development of KCs in immunocompetent patients with a history of multiple KCs...
February 8, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28194314/evolutionary-and-functional-implications-of-hypervariable-loci-within-the-skin-virome
#15
Geoffrey D Hannigan, Qi Zheng, Jacquelyn S Meisel, Samuel S Minot, Frederick D Bushman, Elizabeth A Grice
Localized genomic variability is crucial for the ongoing conflicts between infectious microbes and their hosts. An understanding of evolutionary and adaptive patterns associated with genomic variability will help guide development of vaccines and antimicrobial agents. While most analyses of the human microbiome have focused on taxonomic classification and gene annotation, we investigated genomic variation of skin-associated viral communities. We evaluated patterns of viral genomic variation across 16 healthy human volunteers...
2017: PeerJ
https://www.readbyqxmd.com/read/28193249/factors-associated-with-parental-reasons-for-no-intent-to-vaccinate-female-adolescents-with-human-papillomavirus-vaccine-national-immunization-survey-teen-2008-2012
#16
Vinay K Cheruvu, Madhav P Bhatta, Lauren N Drinkard
BACKGROUND: 1) To identify socio-demographic factors associated with parental "no-intent" for their 13-17 year old unvaccinated daughter to receive the human papillomavirus (HPV) vaccine series within the next twelve months, 2) to describe patterns in "no-intent" by socio-demographic factors, and 3) to identify socio-demographic factors associated with parental reasons for "no-intent". METHODS: Data from 2008-2012 National Immunization Survey - Teen (NIS - Teen) were examined in this study...
February 13, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28192460/knowledge-attitudes-practices-and-willingness-to-vaccinate-in-preparation-for-the-introduction-of-hpv-vaccines-in-bamako-mali
#17
Anne S De Groot, Karamoko Tounkara, Mali Rochas, Sarah Beseme, Shahla Yekta, Fanta Siby Diallo, J Kathleen Tracy, Ibrahima Teguete, Ousmane A Koita
Although screening for pre-cancerous cervical lesions and human papilloma virus (HPV) vaccination are accepted and effective means to prevent cervical cancer, women in Mali have limited access to these interventions. In addition, cervical cancer prevention by HPV vaccination has been controversial in some settings. To reduce cervical cancer prevalence and increase HPV vaccine uptake, it is important to understand the level of knowledge about cervical cancer screening and practices related to vaccination in at-risk populations...
2017: PloS One
https://www.readbyqxmd.com/read/28191723/perceptions-of-hpv-and-attitudes-towards-hpv-vaccination-amongst-men-who-have-sex-with-men-a-qualitative-analysis
#18
Tom Nadarzynski, Helen Smith, Daniel Richardson, Alex Pollard, Carrie Llewellyn
OBJECTIVES: Men who have sex with men (MSM) are at risk of genital warts and anal cancer due to human papillomavirus (HPV) infection. This study explores MSMs' perceptions of HPV and HPV vaccination prior to the introduction of this programme. DESIGN: Focus groups and one-to-one interviews with self-identified MSM were conducted between November 2014 and March 2015 in Brighton, UK. METHODS: Participants were recruited from community-based lesbian-gay-bisexual-transgender (LGBT) venues and organizations...
February 13, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28190705/risk-of-autoimmune-diseases-and-human-papilloma-virus-hpv-vaccines-six-years-of-case-referent-surveillance
#19
Lamiae Grimaldi-Bensouda, Michel Rossignol, Isabelle Koné-Paut, Alain Krivitzky, Christine Lebrun-Frenay, Johanna Clet, David Brassat, Caroline Papeix, Marc Nicolino, Pierre-Yves Benhamou, Olivier Fain, Nathalie Costedoat-Chalumeau, Marie-France Courcoux, Jean-François Viallard, Bertrand Godeau, Thomas Papo, Patrick Vermersch, Isabelle Bourgault-Villada, Gerard Breart, Lucien Abenhaim
BACKGROUND: Safety of HPV vaccines is still in question due to reports of autoimmune diseases (ADs) following HPV immunization. OBJECTIVES: To assess the risk of ADs associated with HPV vaccination of female adolescents/young adults in France. METHODS: Systematic prospective case-referent study conducted to assess the risks associated with real-life use of HPV vaccines. Cases were female 11-25 years old with incident ADs [central demyelination/multiple sclerosis (CD/MS), connective tissue disease (CTD), Guillain-Barré syndrome (GBS), type-1 diabetes (T1D), autoimmune thyroiditis (AT), and idiopathic thrombocytopenic purpura (ITP)]...
February 9, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28188796/parents-willingness-to-get-human-papillomavirus-vaccination-for-their-adolescent-children-at-a-pharmacy
#20
William A Calo, Melissa B Gilkey, Parth Shah, Macary W Marciniak, Noel T Brewer
Pharmacies are promising alternative settings for human papillomavirus (HPV) vaccination because of their accessibility and existing infrastructure for vaccine delivery. We sought to examine parents' willingness to get HPV vaccination for their children at pharmacies. In 2014, we conducted a national, online survey of 1255 parents of 11- to 17-year-old adolescents in the United States. Parents reported whether they would be willing to get HPV vaccine for their children at a pharmacy. We used multivariable logistic regression to model willingness for getting HPV vaccinations in pharmacies...
February 7, 2017: Preventive Medicine
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