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HPV vaccines efficacy

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https://www.readbyqxmd.com/read/29767739/efficacy-immunogenicity-and-safety-of-a-9-valent-human-papillomavirus-vaccine-subgroup-analysis-of-participants-from-asian-countries
#1
S M Garland, P Pitisuttithum, H Y S Ngan, C-H Cho, C-Y Lee, C-A Chen, Y C Yang, T-Y Chu, N-F Twu, R Samakoses, Y Takeuchi, T H Cheung, S C Kim, L-M Huang, B-G Kim, Y-T Kim, K-H Kim, Y-S Song, S Lalwani, J-H Kang, M Sakamoto, H-S Ryu, N Bhatla, H Yoshikawa, M C Ellison, S R Han, E Moeller, S Murata, M Ritter, M Sawata, C Shields, A Walia, G Perez, A Luxembourg
Background: A 9-valent human papillomavirus-6/11/16/18/31/33/45/52/58 (9vHPV) vaccine extends coverage to 5 next most common oncogenic types (31/33/45/52/58) in cervical cancer versus quadrivalent HPV (qHPV) vaccine. We describe efficacy, immunogenicity, and safety in Asian participants (India, Hong Kong, South Korea, Japan, Taiwan, and Thailand) from 2 international studies: a randomized, double-blinded, qHPV vaccine-controlled efficacy study (young women aged 16-26 years; NCT00543543; Study 001); and an immunogenicity study (girls and boys aged 9-15 years; NCT00943722; Study 002)...
May 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29747350/-research-progress-of-hpv-therapeutic-vaccine
#2
S Zhao, F H Zhao
Bivalent and quadrivalent HPV vaccine have been approved by CFDA successively in China. However, currently available prophylactic vaccines have no therapeutic effect for established infection or disease. In recent years, based on the application of genomics and proteomics for interpretation of tumor antigen, animal experiments and clinical trials of vaccines aiming at a wide variety of antigens have been conducted. In this review, we summarize about the preclinical and clinical research status of HPV therapeutic vaccine and find that the efficacy of HPV therapeutic vaccine alone or combined with other conventional cancer treatment is satisfying, which has potential clinical application value...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29740819/prophylactic-vaccination-against-human-papillomaviruses-to-prevent-cervical-cancer-and-its-precursors
#3
REVIEW
Marc Arbyn, Lan Xu, Cindy Simoens, Pierre Pl Martin-Hirsch
BACKGROUND: Persistent infection with high-risk human papillomaviruses (hrHPV) types is causally linked with the development of cervical precancer and cancer. HPV types 16 and 18 cause approximately 70% of cervical cancers worldwide. OBJECTIVES: To evaluate the harms and protection of prophylactic human papillomaviruses (HPV) vaccines against cervical precancer and HPV16/18 infection in adolescent girls and women. SEARCH METHODS: We searched MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL) and Embase (June 2017) for reports on effects from trials...
May 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29736980/face-to-face-interventions-for-informing-or-educating-parents-about-early-childhood-vaccination
#4
REVIEW
Jessica Kaufman, Rebecca Ryan, Louisa Walsh, Dell Horey, Julie Leask, Priscilla Robinson, Sophie Hill
BACKGROUND: Early childhood vaccination is an essential global public health practice that saves two to three million lives each year, but many children do not receive all the recommended vaccines. To achieve and maintain appropriate coverage rates, vaccination programmes rely on people having sufficient awareness and acceptance of vaccines.Face-to-face information or educational interventions are widely used to help parents understand why vaccines are important; explain where, how and when to access services; and address hesitancy and concerns about vaccine safety or efficacy...
May 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29734944/barriers-and-facilitators-to-hpv-vaccination-in-primary-care-practices-a-mixed-methods-study-using-the-consolidated-framework-for-implementation-research
#5
Jane M Garbutt, Sherry Dodd, Emily Walling, Amanda A Lee, Katharine Kulka, Rebecca Lobb
BACKGROUND: In the United States, the effective, safe huma papilloma virus (HPV) vaccine is underused and opportunities to prevent cancer continue to be missed. National guidelines recommend completing the 2-3 dose HPV vaccine series by age 13, well before exposure to the sexually transmitted virus. Accurate characterization of the facilitators and barriers to full implementation of HPV vaccine recommendations in the primary care setting could inform effective implementation strategies...
May 7, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29696185/intention-to-prevent-analyses-for-estimating-human-papillomavirus-vaccine-efficacy-in-clinical-studies
#6
Alfred Saah, Oliver Bautista, Alain Luxembourg, Gonzalo Perez
HPV vaccine efficacy trials have been conducted in populations exposed to HPV infection (i.e., sexually active individuals); participants were not excluded from participating in the trials based on their HPV status at baseline. Thus, some participants could have been infected at baseline with 1 or more vaccine HPV types. Because HPV vaccines are prophylactic and do not affect existing HPV infections, prophylactic efficacy was assessed in a per-protocol population (those not infected at enrollment to the HPV type being analyzed who also completed the 3-dose regimen of vaccine and had no protocol violations)...
September 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29693347/comparative-cost-effectiveness-analysis-of-two-different-two-dose-human-papillomavirus-vaccines-in-malaysia
#7
Georges Van Kriekinge, Woo-Yun Sohn, Syed Mohamed Aljunid, Ruey Soon, Chee-Meng Yong, Jing Chen, I-Heng Lee
Purpose: To comparatively evaluate the results of a 2-dose human papillomavirus (HPV) vaccination programme with the AS04-adjuvanted HPV16/18 vaccine (AS04-HPV-16/18v) or HPV-6/11/16/18 vaccine (4vHPVv), in addition to cervical cancer (CC) screening, in Malaysia. Methods: A lifetime Markov model replicating the natural history of HPV in 13-year-old girls was adapted to Malaysia to assess the impact of vaccination on pre-cancerous lesions, genital warts and CC cases, CC deaths, quality-adjusted life years (QALYs), and costs from the perspective of the Malaysian Ministry of Health...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29659751/a-randomized-placebo-controlled-trial-of-the-quadrivalent-hpv-vaccine-in-hiv-infected-adults-age-27-years-or-older-aids-clinical-trials-group-protocol-a5298
#8
Timothy J Wilkin, Huichao Chen, Michelle S Cespedes, Jorge T Leon-Cruz, Catherine Godfrey, Elizabeth Y Chiao, Barbara Bastow, Jennifer Webster-Cyriaque, Qinghua Feng, Joan Dragavon, Robert W Coombs, Rachel M Presti, Alfred Saah, Ross D Cranston
Background: Adults living with HIV are at increased risk for anal and oropharyngeal cancer caused by human papillomavirus (HPV). The efficacy of HPV vaccines in this population is unknown. Methods: Phase 3, double-blind, randomized controlled trial. We assigned HIV-infected adults age 27 or older to the quadrivalent HPV (Types 6, 11, 16, 18) vaccine or placebo (1:1) stratified by sex and presence of anal high-grade squamous intraepithelial lesions on biopsy (bHSIL)...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29628765/low-rate-of-human-papillomavirus-vaccination-among-schoolgirls-in-lebanon-barriers-to-vaccination-with-a-focus-on-mothers-knowledge-about-available-vaccines
#9
Maria J Abou El-Ola, Mariam A Rajab, Dania I Abdallah, Ismail A Fawaz, Lyn S Awad, Hani M Tamim, Ahmad O Ibrahim, Anas M Mugharbil, Rima A Moghnieh
Background: Human papillomavirus (HPV) infection is an established predisposing factor of cervical cancer. In this study, we assessed the awareness about genital warts, cervical cancer, and HPV vaccine among mothers having girls who are at the age of primary HPV vaccination attending a group of schools in Lebanon. We also assessed the rate of HPV vaccination among these girls and the barriers to vaccination in this community. Subjects and methods: This is a cross-sectional, school-based survey...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29617313/the-relationship-of-health-beliefs-with-information-sources-and-hpv-vaccine-acceptance-among-young-adults-in-korea
#10
Jarim Kim
Despite the HPV vaccine’s efficacy in preventing cervical cancer, its coverage rates among Asians are very low. To increase immunization coverage among these populations, understanding the psychological factors that affect HPV acceptability is critical. To this end, this study examined the relationships between multidimensional health beliefs and HPV vaccine acceptance, and what information sources effectively foster HPV vaccination-related health beliefs. Data were collected using a survey of 323 undergraduate students in Korea...
April 4, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29606519/parental-acceptability-of-hpv-vaccination-for-boys-and-girls-aged-9-13-years-in-china-a-population-based-study
#11
Zixin Wang, Jingjing Wang, Yuan Fang, Danielle L Gross, Martin C S Wong, Eliza L Y Wong, Joseph T F Lau
BACKGROUND: This study was to investigate parental acceptability of HPV vaccination for their sons and daughters aged 9-13 years under different cost scenarios, and factors associated with parental acceptability at market price. METHODS: Participants were: (1) Chinese speaking parents aged 18-60 years with a Hong Kong ID card; (2) had a son or a daughter aged 9-13 years at the date of the survey; (3) the child had the right to abode in Hong Kong. Random telephone numbers were selected from up-to-date telephone directories of Hong Kong...
March 29, 2018: Vaccine
https://www.readbyqxmd.com/read/29599089/cancer-salient-messaging-for-human-papillomavirus-vaccine-uptake-a-randomized-controlled-trial
#12
Rachael M Porter, Avnika B Amin, Robert A Bednarczyk, Saad B Omer
BACKGROUND AND OBJECTIVES: Vaccination with Human Papillomavirus (HPV) vaccine is recommended for 11-12 years-old, but uptake is suboptimal. Current messaging focuses on HPV infection transmission and prevention. Parents and providers are often uncomfortable discussing sexual practices of adolescents, contributing to the delay/refusal of vaccine. We created a cervical cancer-salient message encouraging HPV vaccination, emphasizing disease salience and disease threat, while promoting self-efficacy...
March 26, 2018: Vaccine
https://www.readbyqxmd.com/read/29571973/options-for-design-of-real-world-impact-studies-of-single-dose-vaccine-schedules
#13
Silvia Franceschi, Gary M Clifford, Iacopo Baussano
Based on existing evidence for efficacy, savings, and advantages in delivery, some countries may elect to pilot or roll out single-dose human papillomavirus (HPV) vaccination (instead of, or in combination with, two-dose) in advance of a WHO policy decision. Accelerated evidence of population-based effectiveness (hereafter referred to as overall effectiveness, OE) of one-dose vaccine programs could be gained through regular surveys of HPV prevalence in young women before and after vaccination introduction. In order to offer the earliest information on OE, one-dose HPV vaccination should target one or more birth cohorts as close as possible to the age when sexual activity most often starts in a given population...
March 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29570136/effectiveness-of-an-educational-intervention-to-increase-human-papillomavirus-knowledge-in-high-risk-minority-women
#14
Adria Suarez Mora, Jessica M Madrigal, Lauren Jordan, Ashlesha Patel
OBJECTIVES: The aims of the study were to evaluate human papillomavirus (HPV) and cervical cancer knowledge in a population at high risk for cervical cancer and to determine whether knowledge and attitudes toward HPV vaccination improve after educational intervention. MATERIALS AND METHODS: This pre-post survey design study was conducted at the John H. Stroger Hospital of Cook County colposcopy clinic. An HPV knowledge and awareness survey was given to participants before their clinical encounter...
March 22, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29553886/estimation-of-the-individual-residual-risk-of-cervical-cancer-after-vaccination-with-the-nonavalent-hpv-vaccine
#15
Karl-Ulrich Petry, Kaatje Bollaerts, Paolo Bonanni, Margaret Stanley, Rosybel Drury, Elmar Joura, Susanne K Kjaer, Chris J L M Meijer, Didier Riethmuller, Benoit Soubeyrand, Pierre Van Damme, Xavier Bosch
BACKGROUND: The nonavalent HPV (9vHPV) vaccine is indicated for active immunisation of individuals from the age of 9 years against cervical, vulvar, vaginal and anal premalignant lesions and cancers causally related to vaccine HPV high risk types 16, 18, 31, 33, 45, 52 and 58, and to the HPV low risk types 6 and 11, causing genital warts. OBJECTIVE: To estimate the lifetime risk (up to the age of 75 years) for developing cervical cancer after vaccinating a HPV naïve girl (e...
March 19, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29541939/analyses-of-repeated-failures-in-cancer-therapy-for-solid-tumors-poor-tumor-selective-drug-delivery-low-therapeutic-efficacy-and-unsustainable-costs
#16
Hiroshi Maeda, Mahin Khatami
For over six decades reductionist approaches to cancer chemotherapies including recent immunotherapy for solid tumors produced outcome failure-rates of 90% (±5) according to governmental agencies and industry. Despite tremendous public and private funding and initial enthusiasm about missile-therapy for site-specific cancers, molecular targeting drugs for specific enzymes such as kinases or inhibitors of growth factor receptors, the outcomes are very bleak and disappointing. Major scientific reasons for repeated failures of such therapeutic approaches are attributed to reductionist approaches to research and infinite numbers of genetic mutations in chaotic molecular environment of solid tumors that are bases of drug development...
March 1, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29483541/factors-influencing-intention-to-obtain-the-hpv-vaccine-in-south-east-asian-and-western-pacific-regions-a-systematic-review-and-meta-analysis
#17
Diviya Santhanes, Che Pui Yong, Yan Ye Yap, Pui San Saw, Nathorn Chaiyakunapruk, Tahir Mehmood Khan
Since licensing in 2006, there has been poor uptake of the HPV vaccine among the targeted population in the South East Asia Region (SEAR) and Western Pacific Region (WPR). A systematic review was conducted to identify the studies exploring the relationship between factors and intention for HPV vaccination among women in SEAR and WPR countries. Nineteen studies were identified as suitable for qualitative synthesis, and three as suitable for meta-analysis. Most women had a positive intention to have an HPV vaccine (range 57%-85%)...
February 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29475377/current-research-into-novel-therapeutic-vaccines-against-cervical-cancer
#18
Marcelo Nazário Cordeiro, Rita de Cássia Pereira De Lima, Francesca Paolini, Alanne Rayssa da Silva Melo, Ana Paula Ferreira Campos, Aldo Venuti, Antonio Carlos De Freitas
Cervical cancer and cervical intraepithelial neoplasia (CIN) are well-known outcomes of a human papillomavirus (HPV) infection. Viral oncogenes expressions like E6, E7, and, recently recognized E5, lead to HPV-related malignant progression. Although HPV prevention by powerful vaccines against most frequent and oncogenic genotypes is feasible, current treatment against cervical neoplasia is distant from an ideal one. In addition, late diagnosis is commonly associated with a poor prognosis. On top of that, radiotherapy, chemotherapy, or surgery are less effective in high-grade lesions...
April 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29474934/design-and-statistical-considerations-for-studies-evaluating-the-efficacy-of-a-single-dose-of-the-human-papillomavirus-hpv-vaccine
#19
Joshua N Sampson, Allan Hildesheim, Rolando Herrero, Paula Gonzalez, Aimee R Kreimer, Mitchell H Gail
Cervical cancer is a leading cause of cancer mortality in women worldwide. Human papillomavirus (HPV) types 16 and 18 cause about 70% of all cervical cancers. Clinical trials have demonstrated that three doses of either commercially available HPV vaccine, Cervarix ® or Gardasil ®, prevent most new HPV 16/18 infections and associated precancerous lesions. Based on evidence of immunological non-inferiority, 2-dose regimens have been licensed for adolescents in the United States, European Union, and elsewhere...
May 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29474117/improving-provider-communication-about-hpv-vaccines-for-vaccine-hesitant-parents-through-the-use-of-motivational-interviewing
#20
Jenna E Reno, Sean O'Leary, Kathleen Garrett, Jennifer Pyrzanowski, Steven Lockhart, Elizabeth Campagna, Juliana Barnard, Amanda F Dempsey
Human papillomavirus (HPV) vaccine uptake is below that of other routine adolescent vaccines. This is due in part to the fact that the HPV vaccine is often not routinely recommended by providers to all eligible adolescents. While providers' recommendations are crucial, even a strongly stated recommendation can be insufficient among HPV vaccine-hesitant parents. Providers must be prepared to respond to parental concerns following giving the recommendation for the HPV vaccine. This paper presents the analysis of implementation of an intervention aimed at improving provider communication with HPV vaccine-hesitant parents...
2018: Journal of Health Communication
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