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https://www.readbyqxmd.com/read/29748568/carf-enrichment-promotes-epithelial-mesenchymal-transition-via-wnt-%C3%AE-catenin-signaling-its-clinical-relevance-and-potential-as-a-therapeutic-target
#1
Rajkumar S Kalra, Anupama Chaudhary, A-Rum Yoon, Priyanshu Bhargava, Amr Omar, Sukant Garg, Chae-Ok Yun, Sunil C Kaul, Renu Wadhwa
CARF (Collaborator of ARF)/CDKN2AIP was discovered as a novel ARF-binding protein. It has been established as an essential cell survival, p53-, and cell proliferation-regulatory protein. Although a moderate upregulation of CARF caused growth arrest and senescence, its excessively enriched levels were shown to facilitate aggressive proliferation and malignant transformation of cancer cells. Here, we examined the relevance of CARF levels in clinical tumors and found its amplification (both at gene and transcript levels) in a variety of invasive and metastatic malignancies...
May 11, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29745557/-effects-of-silencing-snail1-gene-on-the-expression-of-tight-junction-proteins-and-the-migration-ability-of-hep-2-cells
#2
Shuangfeng Liu, Yang Shen, Tang Feng, Xiaoheng Liu
To investigate the effects of Snail1 gene silence on the expression of tight junction proteins and the migration ability of Hep-2 cells, Hep-2 cells were transfected with plasmids which is containing the shRNA of Snail1 gene, and cultured till the cells could be passaged stably (named Sh-snail1 cells). The expression of tight junction proteins (ZO-1, Occludin, Claudin-5) were detected by Western blot. The migration ability of Sh-snail1 cells was investigated by wound healing assay, and the protein expression of members of RhoGTPase family (RhoA, Cdc42) was detected by Western blot, which is closely related to the migration ability...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29744869/isolation-and-identification-of-chemotherapy-enriched-sphere-forming-cells-from-a-patient-with-gastric-cancer
#3
Vahid Bagheri, Bahram Memar, Ramezan Behzadi, Mohsen Aliakbarian, Ali Jangjoo, Mostafa Mehrabi Bahar, Samaneh Talebi, Mehran Gholamin, Mohammad R Abbaszadegan
Gastric cancer (GC) is the third and fifth cause of cancer-associated mortality for men and women throughout the world, respectively. Despite the use of surgery and chemotherapy for GC therapy, there are no efficient therapeutic protocols for it to date. Cancer stem cells (CSCs) due to their pivotal role in tumor initiation, growth, progression, invasion, distant metastasis, recurrence and resistance to anticancer drugs are very appealing targets for cancer therapies. Here, we isolated and identified CSCs from a chemotherapy-treated patient...
May 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29729076/genome-wide-binding-of-transcription-factor-snail1-in-triple-negative-breast-cancer-cells
#4
Varun Maturi, Anita Morén, Stefan Enroth, Carl-Henrik Heldin, Aristidis Moustakas
Transcriptional regulation mediated by the zinc finger protein Snail1 controls early embryogenesis. By binding to the epithelial tumor suppressor CDH1 gene, Snail1 initiates the epithelial-mesenchymal transition (EMT). The EMT generates stem-like cells and promotes invasiveness during cancer progression. Accordingly, Snail1 mRNA and protein is abundantly expressed in triple-negative breast cancers with enhanced metastatic potential and phenotypic signs of the EMT. Such high endogenous Snail1 protein levels permit quantitative chromatin immunoprecipitation-sequencing (ChIP-seq) analysis...
May 4, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29709678/lysyl-oxidase-like-protein-2-loxl2-modules-barrier-function-in-cholangiocytes-in-cholestasis
#5
Marion J Pollheimer, Silvia Racedo, Amanda Mikels-Vigdal, Derek Marshall, Christopher Bowlus, Carolin Lackner, Tobias Madl, Tom H Karlsen, Johannes R Hov, Susan K Lyman, Joanne Adamkewicz, Victoria Smith, Emmanuel Moreau, Gernot Zollner, Tor Jacob Eide, Tatjana Stojakovic, Hubert Scharnagl, Hans-Jürgen Gruber, Rudolf E Stauber, Michael Trauner, Peter Fickert
BACKGROUND: The lysyl oxidase-like protein 2 (LOXL2) promotes stabilization of the extracellular matrix, chemotaxis, cell growth and cell mobility. We aimed to (i) identify stimuli of LOXL2 in cholangiopathies, (ii) characterize the effects of LOXL2 on biliary epithelial cells' (BECs) barrier function, (iii) compare LOXL2 expression in PSC, PBC, and disease controls, and (iv) to determine LOXL2 expression and cellular sources in 4 mouse models for cholangiopathies. METHODS: Cultured murine BECs were challenged with well-known triggers of cellular senescence, hypoxia, phospholipid-deficient Abcb4-/- mouse bile and chenodeoxycholic acid (CDCA) and investigated for LOXL2, SNAIL1 and E-cadherin expression and transepithelial electrical resistance (TEER) with and without LOX-inhibition...
April 27, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29655688/novel-ras-inhibitor-25-o-methylalisol-f-attenuates-epithelial-to-mesenchymal-transition-and-tubulo-interstitial-fibrosis-by-selectively-inhibiting-tgf-%C3%AE-mediated-smad3-phosphorylation
#6
Hua Chen, Tian Yang, Min-Chang Wang, Dan-Qian Chen, Yang Yang, Ying-Yong Zhao
BACKGROUND: Tubulo-interstitial fibrosis (TIF) is the common pathway in the chronic kidney disease (CKD). Epithelial-to-mesenchymal transition (EMT) is a major contributor to the TIF by the increased myofibroblasts. Renin-angiotensin system (RAS) is critical mediator on EMT in progressive CKD. Angiotensin II (ANG) mediates EMT and causes TIF by stimulating transforming growth factor-β1 (TGF-β1). RAS activation could further activate TGF-β1. Inhibition of the RAS is one of the most powerful therapies for progressive CKD...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29617321/exosome-mediated-transfer-of-cancer-cell-resistance-to-antiestrogen-drugs
#7
Svetlana E Semina, Alexander M Scherbakov, Anna A Vnukova, Dmitry V Bagrov, Evgeniy G Evtushenko, Vera M Safronova, Daria A Golovina, Ludmila N Lyubchenko, Margarita V Gudkova, Mikhail A Krasil'nikov
Exosomes are small vesicles which are produced by the cells and released into the surrounding space. They can transfer biomolecules into recipient cells. The main goal of the work was to study the exosome involvement in the cell transfer of hormonal resistance. The experiments were performed on in vitro cultured estrogen-dependent MCF-7 breast cancer cells and MCF-7 sublines resistant to SERM tamoxifen and/or biguanide metformin, which exerts its anti-proliferative effect, at least in a part, via the suppression of estrogen machinery...
April 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29593211/snail1-action-in-tumor-cells-influences-macrophage-polarization-and-metastasis-in-breast-cancer-through-altered-gm-csf-secretion
#8
Audrey Brenot, Brett L Knolhoff, David G DeNardo, Gregory D Longmore
The EMT inducer SNAIL1 regulates breast cancer metastasis and its expression in human primary breast tumor predicts for poor outcomes. During tumor progression SNAIL1 has multiple effects in tumor cells that can impact metastasis. An inflammatory tumor microenvironment also impacts metastasis and recently SNAIL1 has been implicated as modulating the secretion of cytokines that can influence the tumor immune infiltrate. Using a spontaneous genetic model of breast cancer metastasis and syngeneic orthotopic transplant experiments we show that the action of SNAIL1 in primary breast tumor cells is required for breast tumor growth and metastasis...
March 29, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29587413/multifaced-roles-of-the-%C3%AE-v%C3%AE-3-integrin-in-ehlers-danlos-and-arterial-tortuosity-syndromes-dermal-fibroblasts
#9
REVIEW
Nicoletta Zoppi, Nicola Chiarelli, Marco Ritelli, Marina Colombi
The αvβ3 integrin, an endothelial cells' receptor-binding fibronectin (FN) in the extracellular matrix (ECM) of blood vessels, regulates ECM remodeling during migration, invasion, angiogenesis, wound healing and inflammation, and is also involved in the epithelial mesenchymal transition. In vitro-grown human control fibroblasts organize a fibrillar network of FN, which is preferentially bound on the entire cell surface to its canonical α5β1 integrin receptor, whereas the αvβ3 integrin is present only in rare patches in focal contacts...
March 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29559743/stress-induced-phosphoprotein-1-mediates-hepatocellular-carcinoma-metastasis-after-insufficient-radiofrequency-ablation
#10
Tianhong Su, Junbin Liao, Zihao Dai, Lixia Xu, Shuling Chen, Yifei Wang, Zhenwei Peng, Qiuyang Zhang, Sui Peng, Ming Kuang
Recent studies indicated that insufficient radiofrequency ablation (RFA) could endow hepatocellular carcinoma (HCC) with higher aggressive potential. Stress-induced phosphoprotein 1 (STIP1), which was found highly expressed in HCC, is a chaperone molecule mediating cell homeostasis under thermal stress. We aimed to explore the role of STIP1 on the metastasis of residual HCC after RFA. Mice model with orthotopic HCC implants or caudal vein injection were employed to assess potential of lung metastasis and/or intrahepatic metastasis (IHM) of HCC cells...
March 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29549905/the-impact-of-acute-inflammation-on-progression-and-metastasis-in-pancreatic-cancer-animal-model
#11
Keun Soo Ahn, Ji Yeon Hwang, Ho-Seong Han, Sang Tae Kim, Ilseon Hwang, Young-Ok Chun
BACKGROUND: The impact of acute inflammation on cancer is unclear. Therefore, we evaluated the impact of acute inflammation on cancer progression in an animal model concerning morphological change as well as molecular features. MATERIAL AND METHODS: Murine pancreas ductal adenocarcinoma cell line (Panc-02) and zymosan were used for the induction of cancer and acute inflammation respectively, in C57/BL6 mice. In the C group (n = 10), 2 × 107 Panc02 cells were injected into the tail of the pancreas...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29534875/esculetin-suppresses-tumor-growth-and-metastasis-by-targeting-axin2-e-cadherin-axis-in-colorectal-cancer
#12
Won Kyung Kim, Woong Sub Byun, Hwa-Jin Chung, Jedo Oh, Hyen Joo Park, Jae Sue Choi, Sang Kook Lee
Colorectal cancer (CRC) is the most common malignant disease worldwide due to its metastasis via the epithelial-mesenchymal transition (EMT) process. E-cadherin and Wnt signaling are emerging as potential targets for suppressing the EMT. In this context, Axin2 has been recognized as a negative regulator that inhibits glycogen synthase kinase 3β (GSK3β)-mediated degradation of Snail1, a transcriptional repressor of E-cadherin. However, Axin2 can also impede Wnt signaling via β-catenin degradation. Therefore, Axin2 may serve as either a promoter or suppressor of tumors, and the effects of its inhibition on the cell proliferation and metastasis of CRC require further elucidation...
March 10, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29530599/the-glucagon-like-peptide-1-glp-1-analog-liraglutide-attenuates-renal-fibrosis
#13
Ya-Kun Li, Dong-Xia Ma, Zhi-Min Wang, Xiao-Fan Hu, Shang-Lin Li, Hong-Zhe Tian, Meng-Jun Wang, Yan-Wen Shu, Jun Yang
Renal fibrosis is recognized as the common route of all chronic kidney disease (CKD) progressing to end-stage renal disease (ESRD). Additionally, accumulating evidence suggests that epithelial-mesenchymal transition (EMT) plays a significant role in the process of renal fibrogenesis. Liraglutide is a long-acting glucagon-like peptide-1 (GLP-1) analog that has been widely used to treat type 2 diabetes. Recent studies have demonstrated that the GLP-1 analogs could also exert protective effects in cardiac fibrosis models...
March 9, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29482578/nod-like-receptor-x1-functions-as-a-tumor-suppressor-by-inhibiting-epithelial-mesenchymal-transition-and-inducing-aging-in-hepatocellular-carcinoma-cells
#14
Bo Hu, Guang-Yu Ding, Pei-Yao Fu, Xiao-Dong Zhu, Yuan Ji, Guo-Ming Shi, Ying-Hao Shen, Jia-Bin Cai, Zhen Yang, Jian Zhou, Jia Fan, Hui-Chuan Sun, Ming Kuang, Cheng Huang
BACKGROUND: This study was performed to investigate the role of nucleotide-binding oligomerization domain (NOD)-like receptor X1 (NLRX1) in regulating hepatocellular carcinoma (HCC) progression. METHODS: Expression levels of NLRX1 in clinical specimens and cell lines were determined by reverse transcription-polymerase chain reaction (RT-PCR) and western blot (WB). Transwell assays were conducted to evaluate the effect of NLRX1 on cell invasion, and flow cytometry was used to assess apoptosis...
February 26, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29472550/pim1-mediates-epithelial-mesenchymal-transition-by-targeting-smads-and-c-myc-in-the-nucleus-and-potentiates-clear-cell-renal-cell-carcinoma-oncogenesis
#15
Bin Zhao, Lei Liu, Jun Mao, Zhiwei Zhang, Qifei Wang, Quanlin Li
Emerging evidence has shown that the PIM serine/threonine kinase family, including PIM1, PIM2 and PIM3, is associated with tumour progression towards metastasis. PIM1, an attractive molecular target, has been identified as a potential prognostic biomarker for haematological and epithelial malignancies. However, to date, the potential regulatory roles and molecular mechanisms by which PIM1 affects the development and progression of cancers, including clear-cell renal-cell carcinoma (ccRCC), remain largely unknown...
February 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29464030/under-expression-of-ck2%C3%AE-subunit-in-ccrcc-represents-a-complementary-biomarker-of-p-stat3-ser727-that-correlates-with-patient-survival
#16
Jordi Vilardell, Estefania Alcaraz, Eduard Sarró, Enric Trilla, Thaïs Cuadros, Inés de Torres, Maria Plana, Santiago Ramón Y Cajal, Lorenzo A Pinna, Maria Ruzzene, Juan Morote, Anna Meseguer, Emilio Itarte
Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive subtype of renal cancer. STAT3 pathway is altered in these tumors and p-STAT3 Ser727 is an independent prognostic factor for ccRCC. Protein kinase CK2 is altered in different types of tumors and overexpression of CK2α is considered predictive of bad prognosis and metastatic risk. CK2 subunits analyses in ccRCC samples showed increased CK2α/α' nuclear content in all cases, but decreased cytosolic CK2β (CK2βcyt) levels in the more advanced tumors...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29437830/face-morphogenesis-is-promoted-by-pbx-dependent-emt-via-regulation-of-snail1-during-frontonasal-prominence-fusion
#17
Marta Losa, Maurizio Risolino, Bingsi Li, James Hart, Laura Quintana, Irina Grishina, Hui Yang, Irene F Choi, Patrick Lewicki, Sameer Khan, Robert Aho, Jennifer Feenstra, C Theresa Vincent, Anthony M C Brown, Elisabetta Ferretti, Trevor Williams, Licia Selleri
Human cleft lip with or without cleft palate (CL/P) is a common craniofacial abnormality caused by impaired fusion of the facial prominences. We have previously reported that, in the mouse embryo, epithelial apoptosis mediates fusion at the seam where the prominences coalesce. Here, we show that apoptosis alone is not sufficient to remove the epithelial layers. We observed morphological changes in the seam epithelia, intermingling of cells of epithelial descent into the mesenchyme and molecular signatures of epithelial-mesenchymal transition (EMT)...
March 1, 2018: Development
https://www.readbyqxmd.com/read/29424489/hsp27-associates-with-epithelial-mesenchymal-transition-stemness-and-radioresistance-of-salivary-adenoid-cystic-carcinoma
#18
Wei Chen, Xiaohua Ren, Jiashun Wu, Xiaolei Gao, Xiao Cen, Shasha Wang, Surui Sheng, Qianming Chen, Ya-Jie Tang, Xin-Hua Liang, Ya-Ling Tang
Epithelial-mesenchymal transition (EMT) has been shown to associate with cancer stem cells and radioresistance. However, it is obscure whether EMT itself or specific EMT regulators play causal roles in these properties of salivary adenoid cystic carcinoma (SACC). Here, we exhibited that overexpression of HSP27 drove the migration and invasion, induced EMT, as well as mediated TGF-β1-induced EMT in SACC cells, accompanying the up-regulation of Snail1 and Prrx1. Conversely, HSP27 silencing reduced the migration and invasion and contributed to MET of SACC cells...
April 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29409467/arsenic-trioxide-attenuates-stat-3-activity-and-epithelial-mesenchymal-transition-through-induction-of-shp-1-in-gastric-cancer-cells
#19
Sung Ho Kim, Hyo Soon Yoo, Moon Kyung Joo, Taehyun Kim, Jong-Jae Park, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee, Young-Tae Bak
BACKGROUND: We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the role of SH2 domain-containing phosphatase-1 (SHP-1) during this process. METHODS: We used AGS cells, which showed minimal SHP-1 expression and constitutive STAT3 expression. After treatment of ATO, cellular migration and invasion were assessed by using wound closure assay, Matrigel invasion assay and 3-D culture invasion assay...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29402970/the-fgfr4-388arg-variant-promotes-lung-cancer-progression-by-n-cadherin-induction
#20
Álvaro Quintanal-Villalonga, Laura Ojeda-Márquez, Ángela Marrugal, Patricia Yagüe, Santiago Ponce-Aix, Ana Salinas, Amancio Carnero, Irene Ferrer, Sonia Molina-Pinelo, Luis Paz-Ares
The FGFR4-388Arg variant has been related to poor prognosis in several types of cancer, including lung cancer. The mechanism underlying this association has not been addressed in detail in patients with this pathology. Here, we report that this FGFR4 variant induces MAPK and STAT3 activation and causes pro-oncogenic effects in NSCLC in vitro and in vivo. This variant induces the expression of EMT-related genes, such as N-cadherin, vimentin, Snail1 and Twist1. Indeed, the induction of N-cadherin protein expression by this variant is essential for its pro-tumorigenic role...
February 5, 2018: Scientific Reports
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