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Sam Abraham, Mark O'Dea, Darren J Trott, Rebecca J Abraham, David Hughes, Stanley Pang, Genevieve McKew, Elaine Y L Cheong, John Merlino, Sugiyono Saputra, Richard Malik, Thomas Gottlieb
Carbapenem-resistant Enterobacteriaceae (CRE) are a pressing public health issue due to limited therapeutic options to treat such infections. CREs have been predominantly isolated from humans and environmental samples and they are rarely reported among companion animals. In this study we report on the isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from a companion animal. Carbapenemase-producing S. enterica Typhimurium carrying blaIMP-4 was identified from a systemically unwell (index) cat and three additional cats at an animal shelter...
October 21, 2016: Scientific Reports
M G Smith, D Jordan, J S Gibson, R N Cobbold, T A Chapman, S Abraham, D J Trott
OBJECTIVE: To assess herd-to-herd variation in antimicrobial resistance phenotypes and associated antimicrobial resistance genes (ARGs) in faecal commensal Escherichia coli communities isolated from Australian slaughter-age pigs. METHODS: Hydrophobic grid-membrane filtration (HGMF) was used to screen populations of E. coli isolated from faecal samples obtained from pigs prior to or at slaughter. Multiplex PCRs were applied to the pooled DNA extracted from the samples to identify specific ARGs...
October 2016: Australian Veterinary Journal
Belinda Vangchhia, Sam Abraham, Jan M Bell, Peter Collignon, Justine S Gibson, Paul R Ingram, James R Johnson, Karina Kennedy, Darren J Trott, John D Turnidge, David M Gordon
Unlike Escherichia coli strains belonging to phylogroup B2, the clinical significance of strains belonging to phylogroup F is not well understood. Here we report on a collection of phylogroup F strains recovered in Australia from faeces and extra-intestinal sites from humans, companion animals, and native animals, as well as from poultry meat and water samples. The distribution of sequence types was clearly non-random with respect to isolate source. The antimicrobial resistance and virulence trait profiles also varied with the sequence type of the isolate...
September 22, 2016: Microbiology
Lisa A Lesniewski, Douglas R Seals, Ashley E Walker, Grant D Henson, Mark W Blimline, Daniel W Trott, Gary C Bosshardt, Thomas J LaRocca, Brooke R Lawson, Melanie C Zigler, Anthony J Donato
Inhibition of mammalian target of rapamycin, mTOR, extends lifespan and reduces age-related disease. It is not known what role mTOR plays in the arterial aging phenotype or if mTOR inhibition by dietary rapamycin ameliorates age-related arterial dysfunction. To explore this, young (3.8 ± 0.6 months) and old (30.3 ± 0.2 months) male B6D2F1 mice were fed a rapamycin supplemented or control diet for 6-8 weeks. Although there were few other notable changes in animal characteristics after rapamycin treatment, we found that glucose tolerance improved in old mice, but was impaired in young mice, after rapamycin supplementation (both P < 0...
September 22, 2016: Aging Cell
Eric A Thrailkill, Jeremy M Trott, Christopher L Zerr, Mark E Bouton
Recent studies suggest a significant role for context in controlling the acquisition and extinction of simple operant responding. The present experiments examined the contextual control of a heterogeneous behavior chain. Rats first learned a chain in which a discriminative stimulus set the occasion for a procurement response (e.g., pulling a chain), which led to a second discriminative stimulus that occasion-set a consumption response (e.g., pressing a lever) that produced a food-pellet reinforcer. Experiment 1 showed that, after separate extinction of procurement and consumption, each response increased when it was returned to the acquisition context (ABA renewal) or was tested in a new context (AAB renewal)...
October 2016: Journal of Experimental Psychology. Animal Learning and Cognition
Josephine F Trott, Jeffrey Kim, Omran Abu Aboud, Hiromi Wettersten, Benjamin Stewart, Grace Berryhill, Francisco Uzal, Russell C Hovey, Ching-Hsien Chen, Katie Anderson, Ashley Graef, Aaron L Sarver, Jaime F Modiano, Robert H Weiss
Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing. Tryptophan metabolism, which produces immunosuppressive metabolites, is enhanced in RCC. Here we show indolamine-2,3-dioxygenase-1 (IDO1) expression, a kynurenine pathway enzyme, is increased not only in tumor cells but also in the microenvironment of human RCC compared to normal kidney tissues. Neither kynurenine metabolites nor IDO inhibitors affected the survival or proliferation of human RCC or murine renal cell adenocarcinoma (RENCA) cells in vitro...
August 27, 2016: Oncotarget
Klaus Rüdiger Trott
No abstract text is available yet for this article.
August 24, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
David S Yeager, Carissa Romero, Dave Paunesku, Christopher S Hulleman, Barbara Schneider, Cintia Hinojosa, Hae Yeon Lee, Joseph O'Brien, Kate Flint, Alice Roberts, Jill Trott, Daniel Greene, Gregory M Walton, Carol S Dweck
There are many promising psychological interventions on the horizon, but there is no clear methodology for preparing them to be scaled up. Drawing on design thinking, the present research formalizes a methodology for redesigning and tailoring initial interventions. We test the methodology using the case of fixed versus growth mindsets during the transition to high school. Qualitative inquiry and rapid, iterative, randomized "A/B" experiments were conducted with ~3,000 participants to inform intervention revisions for this population...
April 2016: Journal of Educational Psychology
Philip S Bird, Darren J Trott, Deirdre Mikkelsen, Gabriel J Milinovich, Kristine M Hillman, Paul C Burrell, Linda L Blackall
An obligatory anaerobic, Gram-negative cocco-bacillus with black-pigmented colonies was isolated from the oral cavity of selected Australian marsupial species. Phenotypic andmolecular criteria showed that this bacterium was a distinct species within the genus of Porphyromonas, and closely related to Porphyromonas gingivalis and Porphyromonas gulae. This putative novel species and P. gulae could be differentiated from P. gingivalis by catalase activity. Further characterisation by multi-locus enzyme electrophoresis of glutamate dehydrogenase and malate dehydrogenase enzyme mobility and matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis showed that this putative new species could be differentiated phenotypically from P...
August 10, 2016: International Journal of Systematic and Evolutionary Microbiology
Cathleen E Willging, Tania Israel, David Ley, Elise M Trott, Catherine DeMaria, Aaron Joplin, Verida Smiley
Lesbian, gay, bisexual, transgender, and queer or questioning (LGBTQ) people are affected by mental health disparities, especially in rural communities. We trained peer advocates in rural areas in the fundamentals of mental health, outreach, education, and support for this population. The peer advocates were coached by licensed mental health professionals. We evaluated this process through iterative qualitative analysis of semi-structured interviews and written logs from coaches and advocates. The six major themes comprising the results centered on (1) coaching support, (2) peer advocate skills and preparation, (3) working with help seekers, (4) negotiating diversity, (5) logistical challenges in rural contexts, and (6) systemic challenges...
2016: Journal of Gay & Lesbian Mental Health
Gregory A Aarons, Amy E Green, Elise Trott, Cathleen E Willging, Elisa M Torres, Mark G Ehrhart, Scott C Roesch
If evidence-based interventions (EBIs) are not sustained, investments are wasted and public health impact is limited. Leadership has been suggested as a key determinant of implementation and sustainment; however, little empirical work has examined this factor. This mixed-methods study framed using the Exploration, Preparation, Implementation, Sustainment (EPIS) conceptual framework examines leadership in both the outer service system context and inner organizational context in eleven system-wide implementations of the same EBI across two U...
November 2016: Administration and Policy in Mental Health
Alan McKinna, Rosemary Millis
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
Carlie D Trott, Jennifer J Harman, Michelle R Kaufman
This study draws on a social norms framework to examine the influence of interview context-specifically the presence of other women and men-on women's reported attitudes toward intimate partner violence (IPV) in Ethiopia, where IPV rates are among the highest in the world. The sample (16,515 women, ages 15-49) was taken from Ethiopia's 2011 Demographic and Health Survey. Results showed the odds of women "justifying" IPV to be nearly twice as great when other women were present during the interview, and nearly half in the presence of men...
June 29, 2016: Violence Against Women
Teresa M Casey-Trott, Tina M Widowski
High prevalence of keel bone fractures in laying hens is reported in all housing systems. Keel fractures have been associated with pain and restricted mobility in hens in loose housing. The objective was to determine whether keel fractures were associated with activity of hens in furnished cages. Thirty-six pairs of LSL-Lite hens (72 weeks) were enrolled in the study. One hen with a fractured keel and one hen without were identified by palpation in each of 36 groups of hens housed in either 30- or 60-bird cages stocked at 750 cm(2)/hen...
2016: Frontiers in Veterinary Science
Cathleen E Willging, Ethel G Nicdao, Elise M Trott, Nicole C Kellett
Incarceration and community reentry for rural women reflect gendered processes. We draw upon in-depth semi-structured interviews and focus groups to examine the return of women prisoners to underserved rural communities, while attending to the perspectives of their closest social supporters. Our findings underscore the complexity of the reentry process for rural women and its particular impact on their families. We challenge dominant discourses of personal responsibility that detract from the structura violence and injustice shaping reentry experiences for women and their social supporters...
2016: Women & Criminal Justice
Yelena Goldin, Halina L Haag, Charlotte T Trott
Traumatic brain injury (TBI) is a common chronically debilitating consequence of intimate partner violence (IPV). Diagnosis and effective treatment are precluded by poor detection and lack of uniform practice guidelines for TBI screening in IPV. While there are several TBI screening tools commonly employed in clinical and research practices, their applicability to this unique and vulnerable population is unclear. In this review paper, we propose a theoretically-based framework for screening for history of TBI in women exposed to IPV and apply it to investigate the applicability of TBI screening instruments...
May 18, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
M Kurien, N Trott, D S Sanders
Coeliac disease is a common digestive disorder that affects 1% of adults. It is characterised by mucosal damage of the small intestine caused by dietary gluten. The main treatment for coeliac disease is a lifelong gluten-free diet, which can reduce morbidity and mortality and also improve quality of life. Despite the benefits, adhering to this diet is often challenging, with patients often struggling to sustain dietary restriction. Structured follow-up for coeliac disease is recommended in international guidelines for improving adherence and for detecting complications;however, uncertainty exists concerning exactly who should be administering this follow-up care...
October 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
Kate A Worthing, Geoffrey W Coombs, Stanley Pang, Sam Abraham, Sugiyono Saputra, Darren J Trott, David Jordan, Hui San Wong, Rebecca J Abraham, Jacqueline M Norris
No abstract text is available yet for this article.
August 2016: Journal of Antimicrobial Chemotherapy
B R Ongaratti, C B O Silva, G Trott, T Haag, C G S Leães, N P Ferreira, M C Oliveira, J F S Pereira-Lima
Meningiomas are common, usually benign tumors of the central nervous system that have a high rate of post-surgical recurrence or regrowth. We determined expression of the proteins merlin, NDRG2, ERBB2, and c-MYC in meningiomas using immunohistochemistry and assessed relationships between protein expression and gender, age, tumor grade, and recurrence or regrowth. The study sample comprised 60 patients, (44 women and 16 men) with a mean age of 53.2 ± 12.7 years. Tumors were classified as grade I (n=48) or grades II and III (n=12)...
2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Jeffrey J Bednarski, Ruchi Pandey, Emily Schulte, Lynn S White, Bo-Ruei Chen, Gabriel J Sandoval, Masako Kohyama, Malay Haldar, Andrew Nickless, Amanda Trott, Genhong Cheng, Kenneth M Murphy, Craig H Bassing, Jacqueline E Payton, Barry P Sleckman
DNA double-strand breaks (DSBs) activate a canonical DNA damage response, including highly conserved cell cycle checkpoint pathways that prevent cells with DSBs from progressing through the cell cycle. In developing B cells, pre-B cell receptor (pre-BCR) signals initiate immunoglobulin light (Igl) chain gene assembly, leading to RAG-mediated DNA DSBs. The pre-BCR also promotes cell cycle entry, which could cause aberrant DSB repair and genome instability in pre-B cells. Here, we show that RAG DSBs inhibit pre-BCR signals through the ATM- and NF-κB2-dependent induction of SPIC, a hematopoietic-specific transcriptional repressor...
February 8, 2016: Journal of Experimental Medicine
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