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https://www.readbyqxmd.com/read/28328413/oliver-scott-1922-2016
#1
Klaus R Trott
No abstract text is available yet for this article.
December 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28166200/upregulation-of-marcks-in-kidney-cancer-and-its-potential-as-a-therapeutic-target
#2
C-H Chen, L W R Fong, E Yu, R Wu, J F Trott, R H Weiss
Targeted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/vascular endothelial growth factor signaling, are initially effective against kidney cancer (or renal cell carcinoma, RCC); however, drug resistance frequently occurs via subsequent activation of alternative pathways. Through genome-scale integrated analysis of the HIF-α network, we identified the major protein kinase C substrate MARCKS (myristoylated alanine-rich C kinase substrate) as a potential target molecule for kidney cancer...
February 6, 2017: Oncogene
https://www.readbyqxmd.com/read/28074319/trans-fatty-acid-stimulated-mammary-gland-growth-in-ovariectomized-mice-is-fatty-acid-type-and-isomer-specific
#3
Grace E Berryhill, Susan G Miszewski, Josephine F Trott, Jana Kraft, Adam L Lock, Russell C Hovey
We previously reported that the trans-18:2 fatty acid trans-10, cis-12 conjugated linoleic acid (t10,c12-CLA) stimulates mammary gland development independent of estrogen and its receptor. Given the negative consequences of dietary trans-fatty acids on various aspects of human health, we sought to establish whether other trans-fatty acids could similarly induce ovary-independent mammary gland growth in mice. Prepubertal BALB/cJ mice were ovariectomized at 21 days of age then were fed diets enriched with cis-9, trans-11 CLA (c9,t11-CLA), or mixtures of trans-18:1 fatty acids supplied by partially hydrogenated sunflower, safflower, or linseed oil...
March 2017: Lipids
https://www.readbyqxmd.com/read/28012941/age-related-arterial-immune-cell-infiltration-in-mice-is-attenuated-by-caloric-restriction-or-voluntary-exercise
#4
Daniel W Trott, Grant D Henson, Mi H T Ho, Sheilah A Allison, Lisa A Lesniewski, Anthony J Donato
Age-related arterial inflammation is associated with dysfunction of the arteries and increased risk for cardiovascular disease. To determine if aging increases arterial immune cell infiltration as well as the populations of immune cells principally involved, we tested the hypothesis that large elastic and resistance arteries in old mice would exhibit increased immune cell infiltration compared to young controls. Additionally, we hypothesized that vasoprotective lifestyle interventions such as lifelong caloric restriction or 8weeks of voluntary wheel running would attenuate age-related arterial immune cell infiltration...
December 22, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27914637/redo-thoracoabdominal-aortic-aneurysm-repair-a-single-center-experience-over-25%C3%A2-years
#5
Rana O Afifi, Harleen K Sandhu, Amy E Trott, Tom C Nguyen, Charles C Miller, Anthony L Estrera, Hazim J Safi
BACKGROUND: Aortic disease is a lifelong, progressive illness that may require repeated intervention over time. We reviewed our 25-year experience with open redo thoracoabdominal aortic aneurysm (TAAA) and descending thoracic aortic aneurysm (DTAA) repair. Our objectives were to determine patient outcomes after redo repair of DTAA/TAAA and compare them with nonredo repair. We also attempted to identify the risk factors for poor outcome. METHODS: We reviewed all open redo TAAA and DTAA repairs between 1991 and 2014...
November 30, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27887889/development-of-intramammary-drug-delivery-systems-novel-in%C3%A2-vitro-release-method
#6
Sanjay Garg, Wen Wang, Yunmei Song, Patricia Eats, Darren J Trott, Stephen W Page, Kiro R Petrovski
The aim of this study was to develop an in vitro release model for intramammary drug delivery system (IMDS) evaluation. This study was the first to establish an in vitro-in vivo correlation with investigation of an IMDS containing lasalocid. Three different methods including the standard United States Pharmacopeia dissolution method with apparatus 2, a modified United States Pharmacopeia method using a dialysis bag, or a specifically designed enhancer cell system, were assessed for the release study. Full cream milk and water were selected as the release media...
November 23, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27873393/tributes-to-peter-alan-trott-mb-bchir-frcpath
#7
A McKinna, R Millis
No abstract text is available yet for this article.
December 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27842872/first-detection-of-extended-spectrum-cephalosporin-and-fluoroquinolone-resistant-escherichia-coli-in-australian-food-producing-animals
#8
Sam Abraham, David Jordan, Hui S Wong, James R Johnson, Mark A Toleman, David L Wakeham, David M Gordon, John D Turnidge, Joanne L Mollinger, Justine S Gibson, Darren J Trott
This study aimed to define the frequency of resistance to critically important antimicrobials (CIAs) [i.e. extended-spectrum cephalosporins (ESCs), fluoroquinolones (FQs) and carbapenems] among Escherichia coli isolates causing clinical disease in Australian food-producing animals. Clinical E. coli isolates (n=324) from Australian food-producing animals [cattle (n=169), porcine (n=114), poultry (n=32) and sheep (n=9)] were compiled from all veterinary diagnostic laboratories across Australia over a 1-year period...
December 2015: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27785348/how-to-study-the-impact-of-sex-and-gender-in-medical-research-a-review-of-resources
#9
REVIEW
Alyson J McGregor, Memoona Hasnain, Kathryn Sandberg, Mary F Morrison, Michelle Berlin, Justina Trott
There is a growing appreciation by the biomedical community that studying the impact of sex and gender on health, aging, and disease will lead to improvements in human health. Sex- and gender-based comparisons can inform research on disease mechanisms and the development of new therapeutics as well as enhance scientific rigor and reproducibility. This review will assist basic researchers, clinical investigators, as well as epidemiologists, population, and social scientists by providing an annotated bibliography of currently available resource tools on how to consider sex and gender as independent variables in research design and methodology...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27767038/isolation-and-plasmid-characterization-of-carbapenemase-imp-4-producing-salmonella-enterica-typhimurium-from-cats
#10
Sam Abraham, Mark O'Dea, Darren J Trott, Rebecca J Abraham, David Hughes, Stanley Pang, Genevieve McKew, Elaine Y L Cheong, John Merlino, Sugiyono Saputra, Richard Malik, Thomas Gottlieb
Carbapenem-resistant Enterobacteriaceae (CRE) are a pressing public health issue due to limited therapeutic options to treat such infections. CREs have been predominantly isolated from humans and environmental samples and they are rarely reported among companion animals. In this study we report on the isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from a companion animal. Carbapenemase-producing S. enterica Typhimurium carrying blaIMP-4 was identified from a systemically unwell (index) cat and three additional cats at an animal shelter...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27671081/phenotypic-and-genotypic-profiling-of-antimicrobial-resistance-in-enteric-escherichia-coli-communities-isolated-from-finisher-pigs-in-australia
#11
M G Smith, D Jordan, J S Gibson, R N Cobbold, T A Chapman, S Abraham, D J Trott
OBJECTIVE: To assess herd-to-herd variation in antimicrobial resistance phenotypes and associated antimicrobial resistance genes (ARGs) in faecal commensal Escherichia coli communities isolated from Australian slaughter-age pigs. METHODS: Hydrophobic grid-membrane filtration (HGMF) was used to screen populations of E. coli isolated from faecal samples obtained from pigs prior to or at slaughter. Multiplex PCRs were applied to the pooled DNA extracted from the samples to identify specific ARGs...
October 2016: Australian Veterinary Journal
https://www.readbyqxmd.com/read/27666313/phylogenetic-diversity-antimicrobial-susceptibility-and-virulence-characteristics-of-phylogroup-f-escherichia-coli-in-australia
#12
Belinda Vangchhia, Sam Abraham, Jan M Bell, Peter Collignon, Justine S Gibson, Paul R Ingram, James R Johnson, Karina Kennedy, Darren J Trott, John D Turnidge, David M Gordon
Unlike Escherichia coli strains belonging to phylogroup B2, the clinical significance of strains belonging to phylogroup F is not well understood. Here we report on a collection of phylogroup F strains recovered in Australia from faeces and extra-intestinal sites from humans, companion animals and native animals, as well as from poultry meat and water samples. The distribution of sequence types was clearly non-random with respect to isolate source. The antimicrobial resistance and virulence trait profiles also varied with the sequence type of the isolate...
November 2016: Microbiology
https://www.readbyqxmd.com/read/27660040/dietary-rapamycin-supplementation-reverses-age-related-vascular-dysfunction-and-oxidative-stress-while-modulating-nutrient-sensing-cell-cycle-and-senescence-pathways
#13
Lisa A Lesniewski, Douglas R Seals, Ashley E Walker, Grant D Henson, Mark W Blimline, Daniel W Trott, Gary C Bosshardt, Thomas J LaRocca, Brooke R Lawson, Melanie C Zigler, Anthony J Donato
Inhibition of mammalian target of rapamycin, mTOR, extends lifespan and reduces age-related disease. It is not known what role mTOR plays in the arterial aging phenotype or if mTOR inhibition by dietary rapamycin ameliorates age-related arterial dysfunction. To explore this, young (3.8 ± 0.6 months) and old (30.3 ± 0.2 months) male B6D2F1 mice were fed a rapamycin supplemented or control diet for 6-8 weeks. Although there were few other notable changes in animal characteristics after rapamycin treatment, we found that glucose tolerance improved in old mice, but was impaired in young mice, after rapamycin supplementation (both P < 0...
February 2017: Aging Cell
https://www.readbyqxmd.com/read/27598060/contextual-control-of-chained-instrumental-behaviors
#14
Eric A Thrailkill, Jeremy M Trott, Christopher L Zerr, Mark E Bouton
Recent studies suggest a significant role for context in controlling the acquisition and extinction of simple operant responding. The present experiments examined the contextual control of a heterogeneous behavior chain. Rats first learned a chain in which a discriminative stimulus set the occasion for a procurement response (e.g., pulling a chain), which led to a second discriminative stimulus that occasion-set a consumption response (e.g., pressing a lever) that produced a food-pellet reinforcer. Experiment 1 showed that, after separate extinction of procurement and consumption, each response increased when it was returned to the acquisition context (ABA renewal) or was tested in a new context (AAB renewal)...
October 2016: Journal of Experimental Psychology. Animal Learning and Cognition
https://www.readbyqxmd.com/read/27572319/inhibiting-tryptophan-metabolism-enhances-interferon-therapy-in-kidney-cancer
#15
Josephine F Trott, Jeffrey Kim, Omran Abu Aboud, Hiromi Wettersten, Benjamin Stewart, Grace Berryhill, Francisco Uzal, Russell C Hovey, Ching-Hsien Chen, Katie Anderson, Ashley Graef, Aaron L Sarver, Jaime F Modiano, Robert H Weiss
Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing. Tryptophan metabolism, which produces immunosuppressive metabolites, is enhanced in RCC. Here we show indolamine-2,3-dioxygenase-1 (IDO1) expression, a kynurenine pathway enzyme, is increased not only in tumor cells but also in the microenvironment of human RCC compared to normal kidney tissues. Neither kynurenine metabolites nor IDO inhibitors affected the survival or proliferation of human RCC or murine renal cell adenocarcinoma (RENCA) cells in vitro...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27557929/some-considerations-for-future-research-into-the-risks-of-radiation-induced-cardiovascular-diseases
#16
EDITORIAL
Klaus Rüdiger Trott
No abstract text is available yet for this article.
November 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27524832/using-design-thinking-to-improve-psychological-interventions-the-case-of-the-growth-mindset-during-the-transition-to-high-school
#17
David S Yeager, Carissa Romero, Dave Paunesku, Christopher S Hulleman, Barbara Schneider, Cintia Hinojosa, Hae Yeon Lee, Joseph O'Brien, Kate Flint, Alice Roberts, Jill Trott, Daniel Greene, Gregory M Walton, Carol S Dweck
There are many promising psychological interventions on the horizon, but there is no clear methodology for preparing them to be scaled up. Drawing on design thinking, the present research formalizes a methodology for redesigning and tailoring initial interventions. We test the methodology using the case of fixed versus growth mindsets during the transition to high school. Qualitative inquiry and rapid, iterative, randomized "A/B" experiments were conducted with ~3,000 participants to inform intervention revisions for this population...
April 2016: Journal of Educational Psychology
https://www.readbyqxmd.com/read/27515974/porphyromonas-loveana-sp-nov-isolated-from-the-oral-cavity-of-australian-marsupials
#18
Philip S Bird, Darren J Trott, Deirdre Mikkelsen, Gabriel J Milinovich, Kristine M Hillman, Paul C Burrell, Linda L Blackall
An obligatory anaerobic, Gram-stain-negative coccobacillus with black-pigmented colonies was isolated from the oral cavity of selected Australian marsupial species. Phenotypic and molecular criteria showed that this bacterium was a distinct species within the genus Porphyromonas, and was closely related to Porphyromonas gingivalis and Porphyromonas gulae. This putative novel species and P. gulae could be differentiated from P. gingivalis by catalase activity. Further characterization by multi-locus enzyme electrophoresis of glutamate dehydrogenase and malate dehydrogenase enzyme mobility and matrix-assisted laser desorption ionization time-of-flight MS showed that this putative novel species could be differentiated phenotypically from P...
October 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27458498/coaching-mental-health-peer-advocates-for-rural-lgbtq-people
#19
Cathleen E Willging, Tania Israel, David Ley, Elise M Trott, Catherine DeMaria, Aaron Joplin, Verida Smiley
Lesbian, gay, bisexual, transgender, and queer or questioning (LGBTQ) people are affected by mental health disparities, especially in rural communities. We trained peer advocates in rural areas in the fundamentals of mental health, outreach, education, and support for this population. The peer advocates were coached by licensed mental health professionals. We evaluated this process through iterative qualitative analysis of semi-structured interviews and written logs from coaches and advocates. The six major themes comprising the results centered on (1) coaching support, (2) peer advocate skills and preparation, (3) working with help seekers, (4) negotiating diversity, (5) logistical challenges in rural contexts, and (6) systemic challenges...
2016: Journal of Gay & Lesbian Mental Health
https://www.readbyqxmd.com/read/27439504/the-roles-of-system-and-organizational-leadership-in-system-wide-evidence-based-intervention-sustainment-a-mixed-method-study
#20
Gregory A Aarons, Amy E Green, Elise Trott, Cathleen E Willging, Elisa M Torres, Mark G Ehrhart, Scott C Roesch
If evidence-based interventions (EBIs) are not sustained, investments are wasted and public health impact is limited. Leadership has been suggested as a key determinant of implementation and sustainment; however, little empirical work has examined this factor. This mixed-methods study framed using the Exploration, Preparation, Implementation, Sustainment (EPIS) conceptual framework examines leadership in both the outer service system context and inner organizational context in eleven system-wide implementations of the same EBI across two U...
November 2016: Administration and Policy in Mental Health
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