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https://www.readbyqxmd.com/read/28942303/lymphoma-koala-retrovirus-infection-and-reproductive-chlamydiosis-in-a-koala-phascolarctos-cinereus
#1
J Fabijan, L Woolford, S Lathe, G Simmons, F Hemmatzadeh, D J Trott, N Speight
Koala retrovirus (KoRV) infection, thought to be associated with lymphoid neoplasia, and Chlamydia pecorum-related ocular and urogenital disease are both highly prevalent in eastern Australian koala (Phascolarctos cinereus) populations. However, in South Australian koalas, little is known about KoRV infection and C. pecorum-associated disease. We report the first South Australian case of lymphoma in a KoRV-A-positive female koala also affected by severe reproductive chlamydiosis. The koala was from the Mount Lofty Ranges population and was presented with hindlimb lameness...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28938404/the-transcriptome-of-estrogen-independent-mammary-growth-in-female-mice-reveals-that-not-all-mammary-glands-are-created-equally
#2
Grace E Berryhill, Danielle G Lemay, Josephine F Trott, Lucila Aimo, Adam L Lock, Russell C Hovey
Allometric growth of ducts in the mammary glands (MG) is widely-held to be estrogen (E)-dependent. We previously discovered that the dietary fatty acid trans-10, cis-12 conjugated linoleic acid (CLA) stimulates E-independent allometric growth and TEB formation in ovariectomized mice. Given the similar phenotype induced by E and CLA, we investigated the shared and/or divergent mechanisms underlying these changes. We confirmed MG growth induced by CLA is temporally distinct from that elicited by E, then used RNA-Sequencing to compare the transcriptome of the MG during similar proliferative and morphological states...
July 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/28873428/evaluation-of-robenidine-analog-ncl195-as-a-novel-broad-spectrum-antibacterial-agent
#3
Abiodun D Ogunniyi, Manouchehr Khazandi, Andrew J Stevens, Sarah K Sims, Stephen W Page, Sanjay Garg, Henrietta Venter, Andrew Powell, Karen White, Kiro R Petrovski, Geraldine Laven-Law, Eliane G Tótoli, Hérida R Salgado, Hongfei Pi, Geoffrey W Coombs, Dean L Shinabarger, John D Turnidge, James C Paton, Adam McCluskey, Darren J Trott
The spread of multidrug resistance among bacterial pathogens poses a serious threat to public health worldwide. Recent approaches towards combating antimicrobial resistance include repurposing old compounds with known safety and development pathways as new antibacterial classes with novel mechanisms of action. Here we show that an analog of the anticoccidial drug robenidine (4,6-bis(2-((E)-4-methylbenzylidene)hydrazinyl)pyrimidin-2-amine; NCL195) displays potent bactericidal activity against Streptococcus pneumoniae and Staphylococcus aureus by disrupting the cell membrane potential...
2017: PloS One
https://www.readbyqxmd.com/read/28865492/pathobiology-of-the-129-stat1-mouse-model-of-human-age-related-er-positive-breast-cancer-with-an-immune-infiltrate-excluded-phenotype
#4
Hidetoshi Mori, Jane Q Chen, Robert D Cardiff, Zsófia Pénzváltó, Neil E Hubbard, Louis Schuetter, Russell C Hovey, Josephine F Trott, Alexander D Borowsky
BACKGROUND: Stat1 gene-targeted knockout mice (129S6/SvEvTac-Stat1 (tm1Rds)) develop estrogen receptor-positive (ER(+)), luminal-type mammary carcinomas at an advanced age. There is evidence for both host environment as well as tumor cell-intrinsic mechanisms to initiate tumorigenesis in this model. In this report, we summarize details of the systemic and mammary pathology at preneoplastic and tumor-bearing time points. In addition, we investigate tumor progression in the 129:Stat1 (-/-) host compared with wild-type 129/SvEv, and we describe the immune cell reaction to the tumors...
September 2, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28830308/online-eeg-classification-of-covert-speech-for-brain-computer-interfacing
#5
Alborz Rezazadeh Sereshkeh, Robert Trott, Aurélien Bricout, Tom Chau
Brain-computer interfaces (BCIs) for communication can be nonintuitive, often requiring the performance of hand motor imagery or some other conversation-irrelevant task. In this paper, electroencephalography (EEG) was used to develop two intuitive online BCIs based solely on covert speech. The goal of the first BCI was to differentiate between 10[Formula: see text]s of mental repetitions of the word "no" and an equivalent duration of unconstrained rest. The second BCI was designed to discern between 10[Formula: see text]s each of covert repetition of the words "yes" and "no"...
June 13, 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28800825/efficacy-evaluation-of-a-new-water-sanitizer-for-increasing-the-shelf-life-of-southern-australian-king-george-whiting-and-tasmanian-atlantic-salmon-fillets
#6
Manouchehr Khazandi, Permal Deo, Sergio Ferro, Henrietta Venter, Hongfei Pi, Simon Crabb, Tony Amorico, Abiodun D Ogunniyi, Darren J Trott
The bacterial species and specific spoilage organisms associated with the Southern Australian King George Whiting (KGW) and Tasmanian Atlantic Salmon (TAS), and the efficacy of a HOCl-containing water-based sanitization product (Electro-Chemically Activated Solution, by ECAS4) in extending the shelf life of KGW and TAS fillets were evaluated. Fillets were washed with an ECAS4 solution containing either 45 ppm or 150 ppm of free chlorine and bacterial species enumerated on selective and non-selective media, followed by identification of pure isolates by 16 S rRNA gene sequencing...
December 2017: Food Microbiology
https://www.readbyqxmd.com/read/28797210/removal-of-methyl-orange-by-heterogeneous-fenton-catalysts-prepared-using-glycerol-as-green-reducing-agent
#7
Natália S F Trotte, M Alzamora, D R Sánchez, Nakédia M F Carvalho
This study aims to prepare environmentally friendly iron catalysts supported on silica, using glycerol as green reducing and stabilizing agent, for application in heterogeneous Fenton degradation of the pollutant dye methyl orange. The catalysts were characterized by XRD, AAS, SEM, TEM, thermogravimetric analyses, Mössbauer and FTIR spectroscopies, which revealed the formation of iron(II)/(III) oxalates from the oxidation of glycerol by the iron(III) nitrate precursor. Besides, iron oxihydroxide nanoparticles with superparamagnetic behavior were also formed...
August 10, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28793094/therapeutic-nursing-care-transition-in-sexuality-of-the-elderly-caregiving-spouse
#8
Claudia Feio da Maia Lima, Célia Pereira Caldas, Iraci Dos Santos, Liana Amorim Correa Trotte, Bárbara Martins Corrêa da Silva
Objective: To understand the transitions experienced, and the conditions and expected response patterns to changes in sexuality of the spouse-caregiver of the elderly, during progression of the dementia process. Method: A qualitative research study, conducted at the neurogeriatric clinic between May of 2014 and May of 2015. An intensive, individual interview was administered to 12 elderly caregivers. Thematic content analysis was applied, using the theoretical model of Transition Theory...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28683857/unanswered-questions
#9
Michael Schlander, Oliver Schwarz, Götz-Erik Trott
No abstract text is available yet for this article.
June 23, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28674678/tangential-field-radiotherapy-for-breast-cancer-the-dose-to-the-heart-and-heart-subvolumes-what-structures-must-be-contoured-in-future-clinical-trials
#10
Marciana Nona Duma, Anne-Claire Herr, Kai Joachim Borm, Klaus Rüdiger Trott, Michael Molls, Markus Oechsner, Stephanie Elisabeth Combs
BACKGROUND AND PURPOSE: The aim of the present study was to evaluate if it is feasible for experienced radiation oncologists to visually sort out patients with a large dose to the heart. This would facilitate large retrospective data evaluations. And in case of an insufficient visual assessment, to define which structures should be contoured and which structures can be skipped as their dose can be derived from other easily contoured structures for future clinical trials. MATERIAL AND METHODS: Planning CTs of left-sided breast cancer patients treated with 3D-conformal radiotherapy by tangential fields were visually divided into two groups: with an estimated high dose (HiD) and with an estimated low dose (LoD) to the heart...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28598251/molecular-characterization-of-methicillin-resistant-staphylococcus-aureus-isolated-from-australian-animals-and-veterinarians
#11
Kate A Worthing, Sam Abraham, Stanley Pang, Geoffrey W Coombs, Sugiyono Saputra, David Jordan, Hui S Wong, Rebecca J Abraham, Darren J Trott, Jacqueline M Norris
This study aimed to determine the frequency and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) from Australian animals and whether animal-derived MRSA was similar to that from Australian veterinarians. A total of 1,080 clinical coagulase positive Staphylococcus isolates from Australian animals were collected during 2013. Sixteen (4%) of 360 S. aureus isolates were MRSA. Most MRSA came from companion animals, while none came from livestock. MRSA isolates were characterized using whole genome sequencing...
June 9, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28591650/long-term-culture-of-self-renewing-pancreatic-progenitors-derived-from-human-pluripotent-stem-cells
#12
Jamie Trott, Ee Kim Tan, Sheena Ong, Drew M Titmarsh, Simon L I J Denil, Maybelline Giam, Cheng Kit Wong, Jiaxu Wang, Mohammad Shboul, Michelle Eio, Justin Cooper-White, Simon M Cool, Giulia Rancati, Lawrence W Stanton, Bruno Reversade, N Ray Dunn
Pluripotent stem cells have been proposed as an unlimited source of pancreatic β cells for studying and treating diabetes. However, the long, multi-step differentiation protocols used to generate functional β cells inevitably exhibit considerable variability, particularly when applied to pluripotent cells from diverse genetic backgrounds. We have developed culture conditions that support long-term self-renewal of human multipotent pancreatic progenitors, which are developmentally more proximal to the specialized cells of the adult pancreas...
June 6, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28589593/editorial-repeat-duodenal-biopsy-for-patients-with-coeliac-disease-physician-heal-thyself-and-dietitian-heal-the-patient
#13
EDITORIAL
N Trott, M Kurien, D S Sanders
No abstract text is available yet for this article.
July 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28561194/impact-of-the-ile105val-polymorphism-of-the-glutathione-s-transferase-p1-gstp1-gene-on-obesity-and-markers-of-cardiometabolic-risk-in-young-adult-population
#14
E O Chielle, A Trott, B da Silva Rosa, J N Casarin, P C Fortuna, I B M da Cruz, M B Moretto, R N Moresco
The aim of the study was to investigate the association between Glutathione S-transferase P1 (GSTP1) gene polymorphism with obesity and markers of cardiometabolic risk. A cross-sectional study was carried out in individuals aged≥18 and ≤30 years. The study included 54 normal weight, 27 overweight and 68 obese volunteers. Anthropometric measurements and biochemical parameters were evaluated, the DNA was extracted from blood samples and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure GSTP1 Ile(105)Val gene polymorphism of the study participants...
May 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28545714/anticystogenic-activity-of-a-small-molecule-pak4-inhibitor-may-be-a-novel-treatment-for-autosomal-dominant-polycystic-kidney-disease
#15
Vicki J Hwang, Xia Zhou, Xiaonan Chen, Josephine Trott, Omran Abu Aboud, Kyuhwan Shim, Lai Kuan Dionne, Kenneth J Chmiel, William Senapedis, Erkan Baloglu, Moe R Mahjoub, Xiaogang Li, Robert H Weiss
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common hereditary renal disease with no currently available targeted therapies. Based on the established connection between β-catenin signaling and renal ciliopathies, and on data from our and other laboratories showing striking similarities of this disease and cancer, we evaluated the use of an orally bioavailable small molecule, KPT-9274 (a dual inhibitor of the protein kinase PAK4 and nicotinamide phosphoribosyl transferase), for treatment of ADPKD...
October 2017: Kidney International
https://www.readbyqxmd.com/read/28514013/antimicrobial-prescribing-in-dogs-and-cats-in-australia-results-of-the-australasian-infectious-disease-advisory-panel-survey
#16
L Y Hardefeldt, S Holloway, D J Trott, M Shipstone, V R Barrs, R Malik, M Burrows, S Armstrong, G F Browning, M Stevenson
BACKGROUND: Investigations of antimicrobial use in companion animals are limited. With the growing recognition of the need for improved antimicrobial stewardship, there is urgent need for more detailed understanding of the patterns of antimicrobial use in this sector. OBJECTIVES: To investigate antimicrobial use for medical and surgical conditions in dogs and cats by Australian veterinarians. METHODS: A cross-sectional study was performed over 4 months in 2011...
July 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28488759/association-between-t102c-5-ht2a-receptor-gene-polymorphism-and-5-year-mortality-risk-among-brazilian-amazon-riparian-elderly-population
#17
Tális O Silva, Ivo Jung, Alexis Trott, Cláudia G Bica, Jeferson N Casarin, Paola C Fortuna, Euler E Ribeiro, Fernanda D de Assis, Guilherme C Figueira, Fernanda Barbisan, Maria Fernanda Manica-Cattani, Beatriz S R Bonadiman, Lucien J Houenou, Pedro Antônio S do Prado-Lima, Ivana B M da Cruz
OBJECTIVE: Serotonin (5-HT) is a pleiotropic molecule that exerts several functions on brain and peripheral tissues via different receptors. The gene for the 5-HT2A receptor shows some variations, including a T102C polymorphism, that have been associated with increased risk of neuropsychiatric and vascular disorders. However, the potential impact of 5-HT2A imbalance caused by genetic variations on the human lifespan has not yet been established. METHODS: We performed a prospective study involving an Amazon riparian elderly free-living population in Maués City, Brazil, with a 5-year follow-up...
May 10, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28476613/emergence-of-multidrug-resistance-in-locally-acquired-human-infections-with-salmonella-typhimurium-in-australia-owing-to-a-new-clade-harbouring-blactx-m-9
#18
Sarah J Sparham, Jason C Kwong, Mary Valcanis, Marion Easton, Darren J Trott, Torsten Seemann, Timothy P Stinear, Benjamin P Howden
Antimicrobial resistance in non-typhoidal Salmonella is a critical problem globally, with the emergence of resistance to third-generation cephalosporins (3GCs) a particular concern. The aim of this study was to use whole-genome sequencing (WGS) to characterise recently identified human and non-human isolates of 3GC-resistant Salmonella enterica subsp. enterica serovar Typhimurium from Australia. The Illumina NextSeq sequencing platform was used to determine the genome sequences of 78 S. Typhimurium definitive type 44 isolated in Australia between 1992 and 2016, including 31 3GC-resistant isolates...
May 2, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28470877/in-vitro-comparison-of-the-dermal-penetration-of-three-different-topical-formulations-containing-lasalocid
#19
Evie C Knight, Darren J Trott, Stephen W Page, Sanjay Garg, Qian Zhang, Yunmei Song, Esmaeil Ebrahimie, Paul C Mills, Michael A Shipstone
BACKGROUND: Topical antimicrobial preparations are of utmost importance in treating suspected and confirmed meticillin-resistant Staphylococcus pseudintermedius (MRSP) infections due to the increasing incidence of widespread resistance to systemic antimicrobials. Lasalocid is active against MRSP in vitro and this may become an important topical antimicrobial for the treatment of canine pyoderma. HYPOTHESIS/OBJECTIVES: To determine effects of various formulation types on penetration and retention of lasalocid applied to canine skin in vitro...
May 3, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28470871/survival-of-staphylococcus-pseudintermedius-in-modified-romanowsky-staining-solutions
#20
Angus Misan, Wei Yee Chan, Darren Trott, Peter B Hill
BACKGROUND: Stains that are used regularly for patient-side diagnosis to rapidly identify bacterial and fungal infections could become contaminated by common pathogens, such as Staphylococcus pseudintermedius, during slide immersion. HYPOTHESIS/OBJECTIVES: To determine whether the inoculation of S. pseudintermedius into modified Romanowsky type stains (Quick Dip(®) ) results in viable bacterial contamination and whether this is influenced by the addition of organic debris (canine hair and skin)...
May 3, 2017: Veterinary Dermatology
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