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https://www.readbyqxmd.com/read/28598251/molecular-characterization-of-methicillin-resistant-staphylococcus-aureus-isolated-from-australian-animals-and-veterinarians
#1
Kate A Worthing, Sam Abraham, Stanley Pang, Geoffrey W Coombs, Sugiyono Saputra, David Jordan, Hui S Wong, Rebecca J Abraham, Darren J Trott, Jacqueline M Norris
This study aimed to determine the frequency and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) from Australian animals and whether animal-derived MRSA was similar to that from Australian veterinarians. A total of 1,080 clinical coagulase positive Staphylococcus isolates from Australian animals were collected during 2013. Sixteen (4%) of 360 S. aureus isolates were MRSA. Most MRSA came from companion animals, while none came from livestock. MRSA isolates were characterized using whole genome sequencing...
June 9, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28591650/long-term-culture-of-self-renewing-pancreatic-progenitors-derived-from-human-pluripotent-stem-cells
#2
Jamie Trott, Ee Kim Tan, Sheena Ong, Drew M Titmarsh, Simon L I J Denil, Maybelline Giam, Cheng Kit Wong, Jiaxu Wang, Mohammad Shboul, Michelle Eio, Justin Cooper-White, Simon M Cool, Giulia Rancati, Lawrence W Stanton, Bruno Reversade, N Ray Dunn
Pluripotent stem cells have been proposed as an unlimited source of pancreatic β cells for studying and treating diabetes. However, the long, multi-step differentiation protocols used to generate functional β cells inevitably exhibit considerable variability, particularly when applied to pluripotent cells from diverse genetic backgrounds. We have developed culture conditions that support long-term self-renewal of human multipotent pancreatic progenitors, which are developmentally more proximal to the specialized cells of the adult pancreas...
June 6, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28589593/editorial-repeat-duodenal-biopsy-for-patients-with-coeliac-disease-physician-heal-thyself-and-dietitian-heal-the-patient
#3
EDITORIAL
N Trott, M Kurien, D S Sanders
No abstract text is available yet for this article.
July 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28561194/impact-of-the-ile105val-polymorphism-of-the-glutathione-s-transferase-p1-gstp1-gene-on-obesity-and-markers-of-cardiometabolic-risk-in-young-adult-population
#4
E O Chielle, A Trott, B da Silva Rosa, J N Casarin, P C Fortuna, I B M da Cruz, M B Moretto, R N Moresco
The aim of the study was to investigate the association between Glutathione S-transferase P1 (GSTP1) gene polymorphism with obesity and markers of cardiometabolic risk. A cross-sectional study was carried out in individuals aged≥18 and ≤30 years. The study included 54 normal weight, 27 overweight and 68 obese volunteers. Anthropometric measurements and biochemical parameters were evaluated, the DNA was extracted from blood samples and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure GSTP1 Ile(105)Val gene polymorphism of the study participants...
May 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28545714/anticystogenic-activity-of-a-small-molecule-pak4-inhibitor-may-be-a-novel-treatment-for-autosomal-dominant-polycystic-kidney-disease
#5
Vicki J Hwang, Xia Zhou, Xiaonan Chen, Josephine Trott, Omran Abu Aboud, Kyuhwan Shim, Lai Kuan Dionne, Kenneth J Chmiel, William Senapedis, Erkan Baloglu, Moe R Mahjoub, Xiaogang Li, Robert H Weiss
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common hereditary renal disease with no currently available targeted therapies. Based on the established connection between β-catenin signaling and renal ciliopathies, and on data from our and other laboratories showing striking similarities of this disease and cancer, we evaluated the use of an orally bioavailable small molecule, KPT-9274 (a dual inhibitor of the protein kinase PAK4 and nicotinamide phosphoribosyl transferase), for treatment of ADPKD...
May 23, 2017: Kidney International
https://www.readbyqxmd.com/read/28514013/antimicrobial-prescribing-in-dogs-and-cats-in-australia-results-of-the-australasian-infectious-disease-advisory-panel-survey
#6
L Y Hardefeldt, S Holloway, D J Trott, M Shipstone, V R Barrs, R Malik, M Burrows, S Armstrong, G F Browning, M Stevenson
BACKGROUND: Investigations of antimicrobial use in companion animals are limited. With the growing recognition of the need for improved antimicrobial stewardship, there is urgent need for more detailed understanding of the patterns of antimicrobial use in this sector. OBJECTIVES: To investigate antimicrobial use for medical and surgical conditions in dogs and cats by Australian veterinarians. METHODS: A cross-sectional study was performed over 4 months in 2011...
May 17, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28488759/association-between-t102c-5-ht2a-receptor-gene-polymorphism-and-5-year-mortality-risk-among-brazilian-amazon-riparian-elderly-population
#7
Tális O Silva, Ivo Jung, Alexis Trott, Cláudia G Bica, Jeferson N Casarin, Paola C Fortuna, Euler E Ribeiro, Fernanda D de Assis, Guilherme C Figueira, Fernanda Barbisan, Maria Fernanda Manica-Cattani, Beatriz S R Bonadiman, Lucien J Houenou, Pedro Antônio S do Prado-Lima, Ivana B M da Cruz
OBJECTIVE: Serotonin (5-HT) is a pleiotropic molecule that exerts several functions on brain and peripheral tissues via different receptors. The gene for the 5-HT2A receptor shows some variations, including a T102C polymorphism, that have been associated with increased risk of neuropsychiatric and vascular disorders. However, the potential impact of 5-HT2A imbalance caused by genetic variations on the human lifespan has not yet been established. METHODS: We performed a prospective study involving an Amazon riparian elderly free-living population in Maués City, Brazil, with a 5-year follow-up...
May 10, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28476613/emergence-of-multidrug-resistance-in-locally-acquired-human-infections-with-salmonella-typhimurium-in-australia-owing-to-a-new-clade-harbouring-blactx-m-9
#8
Sarah J Sparham, Jason C Kwong, Mary Valcanis, Marion Easton, Darren J Trott, Torsten Seemann, Timothy P Stinear, Benjamin P Howden
Antimicrobial resistance in non-typhoidal Salmonella is a critical problem globally, with the emergence of resistance to third-generation cephalosporins (3GCs) a particular concern. The aim of this study was to use whole-genome sequencing (WGS) to characterise recently identified human and non-human isolates of 3GC-resistant Salmonella enterica subsp. enterica serovar Typhimurium from Australia. The Illumina NextSeq sequencing platform was used to determine the genome sequences of 78 S. Typhimurium definitive type 44 isolated in Australia between 1992 and 2016, including 31 3GC-resistant isolates...
May 2, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28470877/in-vitro-comparison-of-the-dermal-penetration-of-three-different-topical-formulations-containing-lasalocid
#9
Evie C Knight, Darren J Trott, Stephen W Page, Sanjay Garg, Qian Zhang, Yunmei Song, Esmaeil Ebrahimie, Paul C Mills, Michael A Shipstone
BACKGROUND: Topical antimicrobial preparations are of utmost importance in treating suspected and confirmed meticillin-resistant Staphylococcus pseudintermedius (MRSP) infections due to the increasing incidence of widespread resistance to systemic antimicrobials. Lasalocid is active against MRSP in vitro and this may become an important topical antimicrobial for the treatment of canine pyoderma. HYPOTHESIS/OBJECTIVES: To determine effects of various formulation types on penetration and retention of lasalocid applied to canine skin in vitro...
May 3, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28470871/survival-of-staphylococcus-pseudintermedius-in-modified-romanowsky-staining-solutions
#10
Angus Misan, Wei Yee Chan, Darren Trott, Peter B Hill
BACKGROUND: Stains that are used regularly for patient-side diagnosis to rapidly identify bacterial and fungal infections could become contaminated by common pathogens, such as Staphylococcus pseudintermedius, during slide immersion. HYPOTHESIS/OBJECTIVES: To determine whether the inoculation of S. pseudintermedius into modified Romanowsky type stains (Quick Dip(®) ) results in viable bacterial contamination and whether this is influenced by the addition of organic debris (canine hair and skin)...
May 3, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28431174/opportunities-for-exercise-during-pullet-rearing-part-ii-long-term-effects-on-bone-characteristics-of-adult-laying-hens-at-the-end-of-lay
#11
T M Casey-Trott, D R Korver, M T Guerin, V Sandilands, S Torrey, T M Widowski
Osteoporosis in laying hens has been a production and welfare concern for several decades. The objective of this study was to determine whether differing opportunities for exercise during pullet rearing influences long-term bone quality characteristics in end-of-lay hens. A secondary objective was to assess whether differing opportunities for exercise in adult housing systems alters bone quality characteristics in end-of-lay hens. Four flock replicates of 588 Lohmann Selected Leghorn-Lite pullets were reared in either conventional cages (Conv) or an aviary rearing system (Avi) and placed into conventional cages (CC), 30-bird furnished cages (FC-S), or 60-bird furnished cages (FC-L) for adult housing...
April 18, 2017: Poultry Science
https://www.readbyqxmd.com/read/28430811/antimicrobial-resistance-in-coagulase-positive-staphylococci-isolated-from-companion-animals-in-australia-a-one-year-study
#12
Sugiyono Saputra, David Jordan, Kate A Worthing, Jacqueline M Norris, Hui S Wong, Rebecca Abraham, Darren J Trott, Sam Abraham
Methicillin-resistant coagulase-positive staphylococci (CoPS) have become increasingly recognised as opportunistic pathogens that limit therapeutic options in companion animals. The frequency of methicillin resistance amongst clinical isolates on an Australia-wide level is unknown. This study determined antimicrobial susceptibility patterns for CoPS isolated from clinical infections in companion animals (dogs, cats and horses) as part of the first nation-wide survey on antimicrobial resistance in animal pathogens in Australia for a one-year period (January 2013 to January 2014)...
2017: PloS One
https://www.readbyqxmd.com/read/28422439/does-touch-inhibit-visual-imagery-a-case-study-on-acquired-blindness
#13
Jana von Trott Zu Solz, Marco Paolini, Sarita Silveira
In a single-case study of acquired blindness, differential brain activation patterns for visual imagery of familiar objects with and without tactile exploration as well as of tactilely explored unfamiliar objects were observed. Results provide new insight into retrieval of visual images from episodic memory and point toward a potential tactile inhibition of visual imagery.
April 19, 2017: PsyCh Journal
https://www.readbyqxmd.com/read/28394397/development-of-perching-behavior-in-3-strains-of-pullets-reared-in-furnished-cages
#14
A M Habinski, L J Caston, T M Casey-Trott, M E Hunniford, T M Widowski
Furnished rearing cages are becoming more widely available to replace conventional systems for pullets. To date, there is little information on how pullets develop perching behavior in furnished cages or how this varies among strains. The objective of this study was to evaluate the use of perches and a platform in a commercial furnished rearing "Combi-Cage" system by 3 pure-bred heritage strains of pullets (Rhode Island Red, Columbian Rock, and White Leghorn). Each cage had 4 elevated locations: one platform and 3 perches of differing heights and positions in the cage...
March 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28390264/selected-life-extending-interventions-reduce-arterial-cxcl10-and-macrophage-colony-stimulating-factor-in-aged-mouse-arteries
#15
Daniel W Trott, Lisa A Lesniewski, Anthony J Donato
Cardiovascular disease (CVD) is the leading cause of death in the industrialized world. Aging is the most predictive risk factor for CVD and is associated with arterial inflammation which contributes to increased CVD risk. Although age-related arterial inflammation has been described in both humans and animals, only a limited number of inflammatory mediators, cytokines and chemokines have been identified. In this investigation we sought to determine whether lifespan extending interventions, including crowded litter early life nutrient deprivation (CL), traditional lifelong caloric restriction (CR) and lifelong Rapamycin treatment (Rap) would attenuate age-related arterial inflammation using multi analyte profiling...
April 5, 2017: Cytokine
https://www.readbyqxmd.com/read/28379533/opportunities-for-exercise-during-pullet-rearing-part-i-effect-on-the-musculoskeletal-characteristics-of-pullets
#16
T M Casey-Trott, D R Korver, M T Guerin, V Sandilands, S Torrey, T M Widowski
Increased load-bearing exercise improves bone quality characteristics in a variety of species, including laying hens. Providing increased opportunities for exercise during the pullet rearing phase, a period of substantial musculoskeletal growth, offers a proactive approach to reducing osteoporosis by improving bone composition. The main objective of this study was to determine whether differing opportunities for exercise during rearing influences pullet musculoskeletal characteristics. Two flock replicates of 588 Lohmann Selected Leghorn-Lite pullets were reared in either standard, conventional cages (Conv) or an aviary rearing system (Avi) from day-old chicks until 16 wk of age...
March 31, 2017: Poultry Science
https://www.readbyqxmd.com/read/28371938/rearing-system-affects-prevalence-of-keel-bone-damage-in-laying-hens-a-longitudinal-study-of-four-consecutive-flocks
#17
T M Casey-Trott, M T Guerin, V Sandilands, S Torrey, T M Widowski
High flock-level prevalence of keel-bone fractures and deviations in laying hens are commonly reported across various housing systems; however, few longitudinal studies exist, especially for furnished and conventional cage systems. Load-bearing exercise improves bone strength and mineral composition in laying hens and has the potential to reduce keel-bone damage, especially if exercise is allowed during critical periods of bone growth throughout the pullet rearing phase. The objective of this study was to determine the prevalence of keel-bone damage in laying hens housed in furnished and conventional cages, and assess whether opportunities for exercise during the pullet rearing phase influenced the prevalence of keel-bone damage throughout the laying period...
March 21, 2017: Poultry Science
https://www.readbyqxmd.com/read/28370511/di-zinc-aryl-complexes-co2-insertions-and-applications-in-polymerisation-catalysis
#18
Charles Romain, Jennifer A Garden, Gemma Trott, Antoine Buchard, Andrew J P White, Charlotte K Williams
Two new di-zinc-aryl complexes, [LZn2 Ph2 ] and [LZn2 (C6 F5 )2 ], coordinated by a diphenol tetraamine macrocyclic ligand have been prepared and fully characterised, including by single-crystal X-ray diffraction experiments. The complexes' reactivities with monomers including carbon dioxide, cyclohexene oxide, phthalic anhydride, isopropanol and phenol were investigated using both experimental studies and density functional theory calculations. In particular, [LZn2 Ph2 ] readily inserts carbon dioxide to form a carboxylate, at 1 bar pressure, whereas [LZn2 (C6 F5 )2 ] does not react...
March 30, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28328413/oliver-scott-1922-2016
#19
Klaus R Trott
No abstract text is available yet for this article.
December 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28166200/upregulation-of-marcks-in-kidney-cancer-and-its-potential-as-a-therapeutic-target
#20
C-H Chen, L W R Fong, E Yu, R Wu, J F Trott, R H Weiss
Targeted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/vascular endothelial growth factor signaling, are initially effective against kidney cancer (or renal cell carcinoma, RCC); however, drug resistance frequently occurs via subsequent activation of alternative pathways. Through genome-scale integrated analysis of the HIF-α network, we identified the major protein kinase C substrate MARCKS (myristoylated alanine-rich C kinase substrate) as a potential target molecule for kidney cancer...
February 6, 2017: Oncogene
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