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https://www.readbyqxmd.com/read/28526580/biomarkers-for-rheumatoid-arthritis-from-molecular-processes-to-diagnostic-applications-current-concepts-and-future-perspectives
#1
REVIEW
Britt Nakken, Gábor Papp, Vidar Bosnes, Margit Zeher, György Nagy, Peter Szodoray
Early diagnosis and immediately started appropriate treatment are mandatory for the prevention of radiographic progression, functional disability and unfavourable disease outcome in rheumatoid arthritis (RA). The current classification criteria for RA include two different types of biomarkers representing inflammatory processes, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) or immune processes including autoantibodies, such as rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA)...
May 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28525857/industrial-air-emissions-and-proximity-to-major-industrial-emitters-are-associated-with-anti-citrullinated-protein-antibodies
#2
Sasha Bernatsky, Audrey Smargiassi, Lawrence Joseph, Phillip Awadalla, Ines Colmegna, Marie Hudson, Marvin J Fritzler
OBJECTIVE: To determine the association of anti-citrullinated antibodies (ACPA) with the ambient air pollutants fine particulate matter (PM2.5) and sulfur dioxide (SO2). METHODS: The CARTaGENE first-wave cohort includes 20,000 general population subjects from Quebec (Canada). On a sample of unselected 1586 subjects, we determined serum, ACPA and performed multivariable logistic regression, for the outcome of positive ACPA, assessing for independent effects of our air pollution variables, adjusting for age, sex, smoking, and French Canadian origin...
May 16, 2017: Environmental Research
https://www.readbyqxmd.com/read/28516880/abatacept-therapy-reduces-cd28-cxcr5-follicular-helper-like-t-cells-in-patients-with-rheumatoid-arthritis
#3
Shunsuke Fukuyo, Shingo Nakayamada, Shigeru Iwata, Satoshi Kubo, Kazuyoshi Saito, Yoshiya Tanaka
OBJECTIVES: The characteristics of T cells targeted by abatacept (ABT) in cases of rheumatoid arthritis (RA) are still unknown. The goal of the study was to determine the pathogenicity of T cells and the predictors of therapeutic effects of ABT. METHODS: We analysed the peripheral T cell phenotype of 34 RA patients via flow cytometry. The correlation of the phenotypes of CD4+ T cells with clinical disease activity and change in CD4+ T cell subsets at baseline and 24 weeks after ABT treatment were evaluated...
April 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28507178/anti-carbamylated-protein-antibodies-are-detectable-in-various-connective-tissue-diseases
#4
Shuichiro Nakabo, Hajime Yoshifuji, Motomu Hashimoto, Yoshitaka Imura, Ran Nakashima, Kosaku Murakami, Nobuo Kuramoto, Shinji Ito, Junko Satoh, Masao Tanaka, Takao Fujii, Tsuneyo Mimori, Koichiro Ohmura
OBJECTIVE: Anti-carbamylated protein (anti-CarP) antibodies are possible diagnostic biomarkers of anticitrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA). We aimed to elucidate the prevalence of anti-CarP antibodies in non-RA connective tissue diseases (CTD) because CTD are important in the differential diagnosis of ACPA-negative RA. METHODS: The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA...
May 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28505163/anti-citrullinated-peptide-antibodies-are-the-strongest-predictor-of-clinically-relevant-radiographic-progression-in-rheumatoid-arthritis-patients-achieving-remission-or-low-disease-activity-a-post-hoc-analysis-of-a-nationwide-cohort-in-japan
#5
Tomohiro Koga, Akitomo Okada, Takaaki Fukuda, Toshihiko Hidaka, Tomonori Ishii, Yukitaka Ueki, Takao Kodera, Munetoshi Nakashima, Yuichi Takahashi, Seiyo Honda, Yoshiro Horai, Ryu Watanabe, Hiroshi Okuno, Toshiyuki Aramaki, Tomomasa Izumiyama, Osamu Takai, Taiichiro Miyashita, Shuntaro Sato, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Hideki Nakamura, Kiyoshi Aoyagi, Katsumi Eguchi, Atsushi Kawakami
OBJECTIVES: To determine prognostic factors of clinically relevant radiographic progression (CRRP) in patients with rheumatoid arthritis (RA) achieving remission or low disease activity (LDA) in clinical practice. METHODS: Using data from a nationwide, multicenter, prospective study in Japan, we evaluated 198 biological disease-modifying antirheumatic drug (bDMARD)-naïve RA patients who were in remission or had LDA at study entry after being treated with conventional synthetic DMARDs (csDMARDs)...
2017: PloS One
https://www.readbyqxmd.com/read/28487154/long-term-mortality-in-patients-with-st-segment-elevation-myocardial-infarction-is-associated-with-anti-citrullinated-protein-antibodies
#6
Maaike P J Hermans, Daniel van der Velden, José M Montero Cabezas, Hein Putter, Tom W J Huizinga, Johan Kuiper, Rene E M Toes, Martin J Schalij, J Wouter Jukema, Diane van der Woude
BACKGROUND: Cardiovascular (CV) mortality is higher in patients with rheumatoid arthritis (RA), in particular when anti-citrullinated protein antibodies (ACPA) are present. Recently, ACPA have also been described in a cohort of patients without RA, but with coronary artery disease (CAD). It is however unknown if ACPA can consistently be found in patients with CAD, and if ACPA are associated with mortality in these patients. The purpose of this study was to assess the relationship between ACPA and long-term outcomes including mortality in patients with ST-elevation myocardial infarction (STEMI) without RA...
April 25, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28471734/acpa-s-74th-annual-meeting
#7
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/28471733/acpa-2017-oral-presentation-abstracts
#8
(no author information available yet)
The peer-reviewed abstracts presented at the 74th Annual Meeting of the ACPA are published as submitted by the authors. For financial conflict of interest disclosure, please visit http://meeting.acpa-cpf.org/disclosures.html.
May 2017: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/28464939/circulating-dna-in-rheumatoid-arthritis-pathological-changes-and-association-with-clinically-used-serological-markers
#9
Elena Rykova, Aleksey Sizikov, Dirk Roggenbuck, Oksana Antonenko, Leonid Bryzgalov, Evgeniy Morozkin, Kseniya Skvortsova, Valentin Vlassov, Pavel Laktionov, Vladimir Kozlov
BACKGROUND: Early diagnosis of rheumatoid arthritis (RA) is crucial to providing effective therapy and often hampered by unspecific clinical manifestations. Elevated levels of extracellular circulating DNA (cirDNA) in patients with autoimmune disease were found to be associated with etiopathogenesis. To our knowledge, this is the first study to investigate the putative diagnostic use of cirDNA in RA and its association with disease activity. METHODS: Blood samples were taken from 63 healthy subjects (HS) and 74 patients with RA...
May 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28451788/the-role-of-autoantibodies-in-the-pathophysiology-of-rheumatoid-arthritis
#10
REVIEW
V F A M Derksen, T W J Huizinga, D van der Woude
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. The presence of autoantibodies in the sera of RA patients has provided many clues to the underlying disease pathophysiology. Based on the presence of several autoantibodies like rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA), anti-carbamylated protein antibodies (anti-CarP), and more recently anti-acetylated protein antibodies RA can be subdivided into seropositive and seronegative disease. The formation of these autoantibodies is associated with both genetic and environmental risk factors for RA, like specific human leukocyte antigen (HLA) alleles and smoking...
April 27, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28429118/-how-frequent-are-poor-prognostic-markers-in-rheumatoid-arthritis-an-estimate-based-on-three-epidemiologic-cohorts
#11
K Albrecht, A Richter, Y Meissner, D Huscher, L Baganz, K Thiele, M Schneider, A Strangfeld, A Zink
BACKGROUND: Unfavorable prognostic factors-high disease activity, early erosions, and autoantibodies-should be considered when making treatment decisions in rheumatoid arthritis (RA). There are little data on the frequency of individual poor prognostic factors among RA patients in daily care. METHODS: Disease activity (Disease Activity Score, DAS28), erosions, antibodies against citrullinated peptides or rheumatoid factor (ACPA/RF+), previous treatment failure, inflammation markers, and functional disability (FFbH < 70) were defined as prognostic factors...
April 20, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28424695/b-cell-tolerance-to-deiminated-histones-in-balb-c-c57bl-6-and-autoimmune-prone-mouse-strains
#12
Nishant Dwivedi, Annica Hedberg, Ying Yi Zheng, Indira Neeli, Minoru Satoh, Laurence Morel, Ole Petter Rekvig, Marko Radic
Deimination, a posttranslational modification of arginine to citrulline carried out by peptidylarginine deiminases, may compromise tolerance of self-antigens. Patients with connective tissue autoimmunity, particularly rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or Felty's syndrome, present with autoantibodies to deiminated histones (dH), which thus form a category of antibodies to citrullinated protein antigens (ACPA). In general, ACPA are a sensitive diagnostic for RA and may form in response to the release of nuclear chromatin (DNA plus dH) from granulocytes, usually referred to as neutrophil extracellular traps...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28412500/the-major-neurotransmitter-systems-in-the-basolateral-amygdala-and-the-ventral-tegmental-area-mediate-morphine-induced-memory-consolidation-impairment
#13
Khadijeh Alsadat Sharifi, Ameneh Rezayof, Anahita Torkaman-Boutorabi, Mohammad-Reza Zarrindast
In the present study, we investigated the possible participation of the endocannabinoid system in the basolateral amygdala and N-methyl-d-aspartate (NMDA) or GABA-A receptor neurotransmission in the ventral tegmental area in the memory consolidation impairment induced by morphine administration. To measure memory formation, step-through type passive avoidance apparatus was used with adult male Wistar rats. The results showed that intraperitoneal (i.p.) administration of morphine (3 and 6mg/kg) after the successful training phase had an amnestic effect and induced memory consolidation impairment...
April 12, 2017: Neuroscience
https://www.readbyqxmd.com/read/28409899/genetic-variation-of-the-alpha-1-antitrypsin-gene-is-associated-with-increased-autoantibody-production-in-rheumatoid-arthritis
#14
Cormac McCarthy, Carl Orr, Laura Fee, Danielle M Dunlea, David J L Hunt, Eimear Dunne, Tomás P Carroll, Paul O'Connell, Geraldine McCarthy, Dermot Kenny, Ursula Fearon, Douglas J Veale, Emer P Reeves, Noel G McElvaney
OBJECTIVE: To examine the prevalence of alpha-1 antitrypsin (AAT) deficiency (AATD) in rheumatoid arthritis (RA), and to determine if AATD is associated with higher levels of rheumatoid factor (RF), antinuclear antibodies (ANA) and anti-citrullinated peptide auto-antibodies (ACPA). METHODS: RF, ANA and ACPA were measured by standard immunoturbidimetry, immunofluorescence and ELISA, respectively. Characterisation of AAT phenotypes was performed by isoelectric focussing and immunofixation...
April 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28403797/is-the-treatment-with-biological-or-non-biological-dmards-a-modifier-of-periodontal-condition-in-patients-with-rheumatoid-arthritis
#15
Consuelo Romero-Sanchez, Constanza Rodríguez, Pedro Santos, Ana María Mesa, Gloria Inés Lafaurie, Sebastian Giraldo, Juliette De Avila, Diana Marcela Castilla, Michelle Durán, Philippe Chalem, Juan Manuel Bello, Rafael Valle
BACKGROUND AND OBJECTIVE: Experimental models suggest the use of different therapy protocols in rheumatoid arthritis (RA) as modulators on periodontal condition. This study evaluated the effects of conventional drug treatment and anti-TNF therapy in patients with RA on microbiological and periodontal condition, establishing the association of markers of periodontal infection with indexes of rheumatic activity. MATERIALS AND METHODS: One hundred seventy nine individuals with RA were evaluated (62 with anti-TNF-α and 115 with only DMARDs)...
April 7, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28398552/carbamylated-albumin-is-one-of-the-target-antigens-of-anti-carbamylated-protein-antibodies
#16
Shuichiro Nakabo, Motomu Hashimoto, Shinji Ito, Moritoshi Furu, Hiromu Ito, Takao Fujii, Hajime Yoshifuji, Yoshitaka Imura, Ran Nakashima, Kosaku Murakami, Nobuo Kuramoto, Masao Tanaka, Junko Satoh, Akihito Ishigami, Satoshi Morita, Tsuneyo Mimori, Koichiro Ohmura
Objectives.: Anti-carbamylated protein (anti-CarP) antibodies are detected in RA patients. Fetal calf serum is used as an antigen source in anti-CarP ELISA, and the precise target antigens have not been found. We aimed to identify the target antigens of anti-CarP antibodies. Methods.: Western blotting of anti-CarP antibodies was conducted. Anti-carbamylated human albumin (CarALB) antibody was detected by in-house ELISA for 493 RA patients and 144 healthy controls (HCs)...
April 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28389208/role-of-the-amygdala-gaba-a-receptors-in-acpa-induced-deficits-during-conditioned-fear-learning
#17
Mohammad Nasehi, Farnaz Roghani, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindast
The basolateral amygdala (BLA) is a key structure for the emotional processing and storage of memories associated with emotional events, especially fear. On the other hand, endocannabinoids and CB1 receptors play a key role in learning and memory partly through long-term synaptic depression of GABAergic synapses in the BLA. The aim of this study was to explore the effects of GABA-A receptor agonist and antagonist in the fear-related memory acquisition deficits induced by ACPA (a selective CB1 cannabinoid receptor agonist)...
April 4, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28376065/chikungunya-virus-and-autoimmunity
#18
Amir Tanay
PURPOSE OF REVIEW: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. Fever, rash and severe arthralgia are the hallmarks of chikungunya fever (CHIKF), the disease caused by this virus. The acute course of the disease usually lasts few weeks to months. Chronic, relapsing or persistent arthralgia and arthritis have been described mimicking rheumatoid arthritis (RA), requiring immunosuppressive drugs.The purpose of this review is to characterize both the chronic clinical course of CHIKF-associated arthritis and the immunological pathogenic mechanisms involved...
April 1, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28373872/type-i-interferon-gene-response-is-increased-in-early-and-established-rheumatoid-arthritis-and-correlates-with-autoantibody-production
#19
Julio E Castañeda-Delgado, Yadira Bastián-Hernandez, Noe Macias-Segura, David Santiago-Algarra, Jose D Castillo-Ortiz, Ana L Alemán-Navarro, Pedro Martínez-Tejada, Leonor Enciso-Moreno, Yolanda Garcia-De Lira, Diana Olguín-Calderón, Leendert A Trouw, Cesar Ramos-Remus, Jose A Enciso-Moreno
BACKGROUND: Rheumatoid arthritis (RA) is an inflammatory debilitating disease that affects the joints in the early and productive phases of an individual's life. Several cytokines have been linked to the disease pathogenesis and are known to contribute to the inflammatory state characteristic of RA. The participation of type I interferon (IFN) in the pathogenesis of the disease has been already described as well as the identity of the genes that are regulated by this molecule, which are collectively known as the type I IFN signature...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28370244/autoantibodies-against-citrullinated-histone-h3-in-rheumatoid-arthritis-and-periodontitis-patients
#20
Koen M J Janssen, Menke J de Smit, Coenraad Withaar, Elisabeth Brouwer, Arie Jan van Winkelhoff, Arjan Vissink, Johanna Westra
AIM: To determine presence of citrullinated histones in inflamed periodontal tissue, and to determine presence of anti-citrullinated histone autoantibodies in sera from rheumatoid arthritis (RA) and periodontitis (PD)-patients . METHODS: Presence of citrullinated histone H3, PAD4 and CD68 was determined in 15 periodontal tissue biopsies from PD-patients by immunohistochemistry. Sera from 36 healthy controls (HC), 113 PD- and 84 RA-patients were assessed on presence of autoantibodies against citrullinated histones by Western blot and against citrullinated histone H3 by ELISA...
March 31, 2017: Journal of Clinical Periodontology
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