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https://www.readbyqxmd.com/read/28708862/anti-citrullinated-protein-antibody-positive-rheumatoid-arthritis-is-primarily-determined-by-rheumatoid-factor-titre-and-the-shared-epitope-rather-than-smoking-per-se
#1
Dan Murphy, Derek Mattey, David Hutchinson
OBJECTIVE: To analyse the relationship between rheumatoid factor (RF) titre, smoking and HLA-DRB1 alleles coding a "shared epitope" (SE) in relation to anti-citrullinated protein antibody (ACPA) positivity in rheumatoid arthritis (RA). METHODS: RA patients (n = 658) attending rheumatology clinics in Cornwall, UK (cohort 1) were stratified according to RF and ACPA titre, and smoking pack years at diagnosis. A further 409 RA patients from North Staffordshire, UK (cohort 2) were studied to confirm the relationship between RF levels, smoking and ACPA positivity in relation to SE status...
2017: PloS One
https://www.readbyqxmd.com/read/28702930/personalized-medicine-in-rheumatology-the-paradigm-of-serum-autoantibodies
#2
REVIEW
Silvia Sirotti, Elena Generali, Angela Ceribelli, Natasa Isailovic, Maria De Santis, Carlo Selmi
The sequencing of the human genome is now well recognized as the starting point of personalized medicine. Nonetheless, everyone is unique and can develop different phenotypes of the same disease, despite identical genotypes, as well illustrated by discordant monozygotic twins. To recognize these differences, one of the easiest and most familiar examples of biomarkers capable of identifying and predicting the outcome of patients is represented by serum autoantibodies. In this review, we will describe the concept of personalized medicine and discuss the predictive, prognostic and preventive role of antinuclear antibodies (ANA), anti-citrullinated peptide antibodies (ACPA), rare autoantibodies and anti-drug antibodies (ADA), to evaluate how these can help to identify different disease immune phenotypes and to choose the best option for treating and monitoring rheumatic patients in everyday practice...
December 2017: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/28695293/hla-class-ii-and-rheumatoid-arthritis-the-bumpy-road-of-revelation
#3
REVIEW
Arieke S B Kampstra, René E M Toes
Rheumatoid arthritis (RA) is a chronic auto-immune disease primarily targeting the joints. Approximately 1% of the population is affected by RA, and despite the improvements in therapeutic interventions, elucidation of the disease pathogenesis is still in its infancy. RA patients can be subdivided on basis of the presence of autoantibodies, especially anti-citrullinated protein antibodies (ACPA). ACPA(+) and ACPA(-) disease most likely differ in aetiology, as different genetic and environmental risk factors are associated with these two disease entities...
July 11, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28683209/acpa-s-75th-annual-meeting
#4
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/28679953/anti-citrullinated-protein-antibodies-cause-arthritis-by-cross-reactivity-to-joint-cartilage
#5
Changrong Ge, Dongmei Tong, Bibo Liang, Erik Lönnblom, Nadine Schneider, Cecilia Hagert, Johan Viljanen, Burcu Ayoglu, Roma Stawikowska, Peter Nilsson, Gregg B Fields, Thomas Skogh, Alf Kastbom, Jan Kihlberg, Harald Burkhardt, Doreen Dobritzsch, Rikard Holmdahl
Today, it is known that autoimmune diseases start a long time before clinical symptoms appear. Anti-citrullinated protein antibodies (ACPAs) appear many years before the clinical onset of rheumatoid arthritis (RA). However, it is still unclear if and how ACPAs are arthritogenic. To better understand the molecular basis of pathogenicity of ACPAs, we investigated autoantibodies reactive against the C1 epitope of collagen type II (CII) and its citrullinated variants. We found that these antibodies are commonly occurring in RA...
July 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28674691/influence-of-cigarette-smoking-on-rheumatoid-arthritis-risk-in-the-han-chinese-population
#6
Jian Yin, Dongyi He, Lei Jiang, Fang Cheng, Qian Guo, Shaolan Huang, Xiaofeng Zeng, Yi Liu, Matthew A Brown, Huji Xu
OBJECTIVES: Cigarette smoking has been shown in European populations to be associated with rheumatoid arthritis (RA) susceptibility. This study aims to examine the association of smoking with RA in the Han Chinese population. METHODS: 718 Han Chinese RA patients and 404 healthy controls were studied. The associations of cigarette smoking (current, former or ever vs. never smokers, and pack-years of exposure) with RA, anti-cyclic citrullinated peptide antibody (ACPA) positive RA, IgM rheumatoid factor (RF) positive RA, and baseline radiographic erosions (modified van der Heijde-Sharp scores) were assessed...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28666971/postmenopausal-osteoporosis-in-rheumatoid-arthritis-the-estrogen-deficiency-immune-mechanisms-link
#7
REVIEW
Rony Sapir-Koren, Gregory Livshits
Rheumatoid arthritis (RA) is characterized, among other factors, by systemic bone loss, reaching ~50% prevalence of osteoporosis in postmenopausal women. This is roughly a doubled prevalence in comparison with age-matched non-RA women. Postmenopausal RA women are more likely to be sero-positive for the anti-citrullinated peptide antibody (ACPA). Our extensive review of recent scientific literature enabled us to propose several mechanisms as responsible for the accelerated bone loss in ACPA(+) RA postmenopausal women...
June 27, 2017: Bone
https://www.readbyqxmd.com/read/28660910/rheumatoid-arthritis-acpa-status-influences-ra-development
#8
Dario Ummarino
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28653215/nlrp1-ptpn22-and-padi4-gene-polymorphisms-and-rheumatoid-arthritis-in-acpa-positive-singaporean-chinese
#9
Liuh Ling Goh, Mei Yun Yong, Wei Qiang See, Edward Yu Wing Chee, Pei Qi Lim, Ee Tzun Koh, Khai Pang Leong
Studies have shown that the genetic risk factors for rheumatoid arthritis (RA) differ substantially between Asian and Caucasian populations. Even among Asian populations, the genetic contributions of NLRP1, PTPN22 and PADI4 have been controversial. Consequently, we sought to address these separate findings and determine whether any of these proposed risk variants are associated with RA susceptibility, onset, DAS activity and erosion in a Singaporean Chinese cohort. We genotyped five SNPs within NLRP1 (rs878329 and rs6502867), PTPN22 (rs2488457 and rs6665194), and PADI4 (rs2240340) in 500 anti-cyclic citrullinated peptide antibody-positive (ACPA) patients with RA and 500 healthy controls using TaqMan assays...
June 26, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28650341/two-rheumatoid-arthritis-specific-autoantigens-correlate-microbial-immunity-with-autoimmune-responses-in-joints
#10
Annalisa Pianta, Sheila L Arvikar, Klemen Strle, Elise E Drouin, Qi Wang, Catherine E Costello, Allen C Steere
In rheumatoid arthritis (RA), immunological triggers at mucosal sites, such as the gut microbiota, may promote autoimmunity that affects joints. Here, we used discovery-based proteomics to detect HLA-DR-presented peptides in synovia or peripheral blood mononuclear cells and identified 2 autoantigens, N-acetylglucosamine-6-sulfatase (GNS) and filamin A (FLNA), as targets of T and B cell responses in 52% and 56% of RA patients, respectively. Both GNS and FLNA were highly expressed in synovia. GNS appeared to be citrullinated, and GNS antibody values correlated with anti-citrullinated protein antibody (ACPA) levels...
June 26, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28643530/assessment-of-local-carotid-stiffness-in-seronegative-and-seropositive-rheumatoid-arthritis
#11
Abdullah Nabi Aslan, Ayşe Nur Şirin Özcan, Şükran Erten, Yakup Alsancak, Tahir Durmaz
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular (CV) disease. Arterial stiffness (AS) is an independent predictor of CV events. This study aimed to analyse local carotid AS parameters in seronegative and seropositive RA patients. DESIGN: Of 347 consecutive RA patients, we selected specifically those who were free of established CV diseases and risk factors. As a result, 140 patients (126 women, 52...
June 23, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28619044/differing-specificities-and-isotypes-of-anti-citrullinated-peptide-protein-antibodies-in-palindromic-rheumatism-and-rheumatoid-arthritis
#12
Sonia Cabrera-Villalba, María José Gomara, Juan D Cañete, Julio Ramírez, Georgina Salvador, Virginia Ruiz-Esquide, Maria Victoria Hernández, José Inciarte-Mundo, Isabel Haro, Raimon Sanmartí
BACKGROUND: To analyze differences in the recognition of anti-citrullinated peptide/protein antibody (ACPA) citrullinated epitopes and isotypes in patients with palindromic rheumatism (PR) and rheumatoid arthritis (RA). METHODS: ACPA fine specificities (citrullinated peptides of enolase, fibrin, and vimentin) and isotypes (IgG, IgM, and IgA) were analyzed in 54 patients with longstanding PR and 54 patients with established RA. RESULTS: CCP2 tested positive in 66...
June 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28616915/-association-of-elevated-platelet-microparticles-with-disease-activity-in-rheumatoid-arthritis
#13
Li-Jia Xue, Bei-Bei Cui, Xi Li, Qiao-Rong Huang, Yi Liu, Hui Lin
OBJECTIVES: To explore the expression of platelets microparticles (PMPs) in peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients and its correlation with clinical inflammatory parameters. METHODS: The levels of PMPs in PB were detected by flow cytometry in 26 active RA patients and 15 healthy control (HC). SF was collected from 16 patients. The percentages of CD62P(+)PMPs, CD154(+)PMPs and clinical parameters (including CRP, ESR, RF and ACPA) were also measured, then the correlations of PMPs with these parameters were analyzed...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28606964/differences-in-the-symptomatic-phase-preceding-acpa-positive-and-acpa-negative-ra-a-longitudinal-study-in-arthralgia-during-progression-to-clinical-arthritis
#14
Leonie E Burgers, Hanna W van Steenbergen, Robin M Ten Brinck, Tom Wj Huizinga, Annette Hm van der Helm-van Mil
OBJECTIVE: Although anticitrullinated protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) have different aetiopathology, the clinical presentation at the time of diagnosis is similar. This study evaluated whether there are phenotypic differences in the symptomatic pre-RA phase. METHODS: Patients with arthralgia included in the Leiden clinically suspect arthralgia cohort who developed arthritis during follow-up were studied (n=67). Symptoms at symptom onset, symptoms and signs at presentation with arthralgia and time to arthritis development were compared between ACPA-positive and ACPA-negative patients...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28603695/the-pag-gene-of-pxo1-is-involved-in-capsule-biosynthesis-of-bacillus-anthracis-pasteur-ii-strain
#15
Xudong Liang, Jin Zhu, Zhongzhi Zhao, Feng Zheng, Huijuan Zhang, Jianchun Wei, Yon Ji, Yinduo Ji
The poly-γ-D-glutamic acid capsule and anthrax toxins are major virulence factors of Bacillus anthracis. Genes responsible for capsule biosynthesis are located on pXO2, whereas genes encoding the toxins, which are composed of edema factors, lethal factors, and protective antigens (PA), are located on pXO1. In this study, we found that the pag null mutation not only eliminated the production of the protective antigen, it also eliminated the ability of the B. anthracis Pasteur II strain to form capsules. qPCR analysis revealed that the deletion of pag decreased the transcription levels of the capABCD operon and its regulatory genes acpA and acpB...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28601249/the-2010-acr-eular-criteria-are-not-sufficiently-accurate-in-the-early-identification-of-autoantibody-negative-rheumatoid-arthritis-results-from-the-leiden-eac-and-espoir-cohorts
#16
Debbie M Boeters, Cécile Gaujoux-Viala, Arnaud Constantin, Annette H M van der Helm-van Mil
OBJECTIVES: The 2010 ACR/EULAR criteria were derived to classify rheumatoid arthritis (RA) earlier in time. Previous studies indeed observed that the 2010 criteria were fulfilled earlier than the 1987 criteria. This study determined whether the 2010 criteria perform equally in early classification of autoantibody-positive and autoantibody-negative RA. METHODS: From the total Leiden-EAC (n = 3448) and ESPOIR (n = 813) RA patients who fulfilled the 1987 RA criteria at 1 year but not at presentation were selected (n = 463 and n = 53, respectively), as these patients were classified with delay with the 1987 criteria...
April 29, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28599787/anti-cd26-autoantibodies-are-involved-in-rheumatoid-arthritis-and-show-potential-clinical-interest
#17
Oscar J Cordero, Rubén Varela-Calviño, Tania López-González, Milica Grujic, Zorica Juranic, Coral Mouriño, Íñigo Hernández-Rodríguez, Marina Rodríguez-López, Bruno Aspe de la Iglesia, José María Pego-Reigosa
OBJECTIVES: Rheumatoid arthritis (RA) patients show low serum levels of the Ag dipeptidyl peptidase IV (DPP-IV/CD26), both soluble CD26 (sCD26) concentration and its DPP-IV activity. The aim of this study was to test if anti-DPP-IV/CD26 Abs (Anti-CD26) cleared sCD26. DESIGN & METHODS: Serum Anti-CD26 and Total titers (as comparison) of isotypes IgA, IgM and IgG as well as sCD26 concentration and DPP-IV activity were measured in a cohort of RA patients undergoing different biological and non-biological therapies (n=105) and controls (n=50)...
June 6, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28598783/anti-homocitrullinated-protein-antibody-isotype-usage-in-rheumatoid-arthritis-and-their-unaffected-first-degree-relatives
#18
David A Bell, Sallie Elhayek, Ewa Cairns, Lillian Barra
OBJECTIVES: The majority of rheumatoid arthritis (RA) patients express anti-citrullinated protein antibodies (ACPA). Unaffected first-degree relatives of RA patients (FDR) also express ACPA, commonly of the IgA isotype. IgG anti-homocitrullinated/carbamylated protein antibodies (AHCPA) have been detected in both RA and FDR. It is unknown whether other isotypes are expressed. We aim to investigate the AHCPA isotype profile in unaffected FDR of RA patients. METHODS: The enrolled subjects were examined by a rheumatologist...
June 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28592200/anti-carbamylated-protein-antibodies-in-systemic-lupus-erythematosus-patients-with-articular-involvement
#19
L Massaro, F Ceccarelli, T Colasanti, M Pendolino, C Perricone, E Cipriano, F Natalucci, G Capalbo, R Lucchetti, A Pecani, M Vomero, R Mancini, F R Spinelli, C Alessandri, G Valesini, F Conti
Objective Several studies have evaluated the prevalence of rheumatoid factor (RF) and anti-citrullinated proteins antibodies (ACPA) in systemic lupus erythematosus (SLE) patients but no data are available on the anti-carbamylated proteins (anti-CarP), a new biomarker for rheumatoid arthritis (RA). We evaluated the anti-CarP prevalence in SLE patients with joint involvement and the associations with different phenotypes. Methods Seventy-eight SLE patients with joint involvement were enrolled (F/M 73/5; mean ± SD age 47...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28582758/rheumatoid-arthritis-recent-advances-on-its-etiology-role-of-cytokines-and-pharmacotherapy
#20
REVIEW
Javaid Alam, Ibrahim Jantan, Syed Nasir Abbas Bukhari
An autoimmune disease is defined as a clinical syndrome resulted from an instigation of both T cell and B cell or individually, in the absence of any present infection or any sort of distinguishable cause. Clonal deletion of auto reactive cells remains the central canon of immunology for decades, keeping the role of T cell and B cell aside, which are actually the guards to recognize the entry of foreign body. According to NIH, 23.5 million Americans are all together affected by these diseases. They are rare, but with the exception of RA...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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