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https://www.readbyqxmd.com/read/28643530/assessment-of-local-carotid-stiffness-in-seronegative-and-seropositive-rheumatoid-arthritis
#1
Abdullah Nabi Aslan, Ayşe Nur Şirin Özcan, Şükran Erten, Yakup Alsancak, Tahir Durmaz
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular (CV) disease. Arterial stiffness (AS) is an independent predictor of CV events. This study aimed to analyse local carotid AS parameters in seronegative and seropositive RA patients. DESIGN: Of 347 consecutive RA patients, we selected specifically those who were free of established CV diseases and risk factors. As a result, 140 patients (126 women, 52...
June 23, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28619044/differing-specificities-and-isotypes-of-anti-citrullinated-peptide-protein-antibodies-in-palindromic-rheumatism-and-rheumatoid-arthritis
#2
Sonia Cabrera-Villalba, María José Gomara, Juan D Cañete, Julio Ramírez, Georgina Salvador, Virginia Ruiz-Esquide, Maria Victoria Hernández, José Inciarte-Mundo, Isabel Haro, Raimon Sanmartí
BACKGROUND: To analyze differences in the recognition of anti-citrullinated peptide/protein antibody (ACPA) citrullinated epitopes and isotypes in patients with palindromic rheumatism (PR) and rheumatoid arthritis (RA). METHODS: ACPA fine specificities (citrullinated peptides of enolase, fibrin, and vimentin) and isotypes (IgG, IgM, and IgA) were analyzed in 54 patients with longstanding PR and 54 patients with established RA. RESULTS: CCP2 tested positive in 66...
June 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28616915/-association-of-elevated-platelet-microparticles-with-disease-activity-in-rheumatoid-arthritis
#3
Li-Jia Xue, Bei-Bei Cui, Xi Li, Qiao-Rong Huang, Yi Liu, Hui Lin
OBJECTIVES: To explore the expression of platelets microparticles (PMPs) in peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients and its correlation with clinical inflammatory parameters. METHODS: The levels of PMPs in PB were detected by flow cytometry in 26 active RA patients and 15 healthy control (HC). SF was collected from 16 patients. The percentages of CD62P(+)PMPs, CD154(+)PMPs and clinical parameters (including CRP, ESR, RF and ACPA) were also measured, then the correlations of PMPs with these parameters were analyzed...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28606964/differences-in-the-symptomatic-phase-preceding-acpa-positive-and-acpa-negative-ra-a-longitudinal-study-in-arthralgia-during-progression-to-clinical-arthritis
#4
Leonie E Burgers, Hanna W van Steenbergen, Robin M Ten Brinck, Tom Wj Huizinga, Annette Hm van der Helm-van Mil
OBJECTIVE: Although anticitrullinated protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) have different aetiopathology, the clinical presentation at the time of diagnosis is similar. This study evaluated whether there are phenotypic differences in the symptomatic pre-RA phase. METHODS: Patients with arthralgia included in the Leiden clinically suspect arthralgia cohort who developed arthritis during follow-up were studied (n=67). Symptoms at symptom onset, symptoms and signs at presentation with arthralgia and time to arthritis development were compared between ACPA-positive and ACPA-negative patients...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28603695/the-pag-gene-of-pxo1-is-involved-in-capsule-biosynthesis-of-bacillus-anthracis-pasteur-ii-strain
#5
Xudong Liang, Jin Zhu, Zhongzhi Zhao, Feng Zheng, Huijuan Zhang, Jianchun Wei, Yon Ji, Yinduo Ji
The poly-γ-D-glutamic acid capsule and anthrax toxins are major virulence factors of Bacillus anthracis. Genes responsible for capsule biosynthesis are located on pXO2, whereas genes encoding the toxins, which are composed of edema factors, lethal factors, and protective antigens (PA), are located on pXO1. In this study, we found that the pag null mutation not only eliminated the production of the protective antigen, it also eliminated the ability of the B. anthracis Pasteur II strain to form capsules. qPCR analysis revealed that the deletion of pag decreased the transcription levels of the capABCD operon and its regulatory genes acpA and acpB...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28601249/the-2010-acr-eular-criteria-are-not-sufficiently-accurate-in-the-early-identification-of-autoantibody-negative-rheumatoid-arthritis-results-from-the-leiden-eac-and-espoir-cohorts
#6
Debbie M Boeters, Cécile Gaujoux-Viala, Arnaud Constantin, Annette H M van der Helm-van Mil
OBJECTIVES: The 2010 ACR/EULAR criteria were derived to classify rheumatoid arthritis (RA) earlier in time. Previous studies indeed observed that the 2010 criteria were fulfilled earlier than the 1987 criteria. This study determined whether the 2010 criteria perform equally in early classification of autoantibody-positive and autoantibody-negative RA. METHODS: From the total Leiden-EAC (n = 3448) and ESPOIR (n = 813) RA patients who fulfilled the 1987 RA criteria at 1 year but not at presentation were selected (n = 463 and n = 53, respectively), as these patients were classified with delay with the 1987 criteria...
April 29, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28599787/anti-cd26-autoantibodies-are-involved-in-rheumatoid-arthritis-and-show-potential-clinical-interest
#7
Oscar J Cordero, Rubén Varela-Calviño, Tania López-González, Milica Grujic, Zorica Juranic, Coral Mouriño, Íñigo Hernández-Rodríguez, Marina Rodríguez-López, Bruno Aspe de la Iglesia, José María Pego-Reigosa
OBJECTIVES: Rheumatoid arthritis (RA) patients show low serum levels of the Ag dipeptidyl peptidase IV (DPP-IV/CD26), both soluble CD26 (sCD26) concentration and its DPP-IV activity. The aim of this study was to test if anti-DPP-IV/CD26 Abs (Anti-CD26) cleared sCD26. DESIGN & METHODS: Serum Anti-CD26 and Total titers (as comparison) of isotypes IgA, IgM and IgG as well as sCD26 concentration and DPP-IV activity were measured in a cohort of RA patients undergoing different biological and non-biological therapies (n=105) and controls (n=50)...
June 6, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28598783/anti-homocitrullinated-protein-antibody-isotype-usage-in-rheumatoid-arthritis-and-their-unaffected-first-degree-relatives
#8
David A Bell, Sallie Elhayek, Ewa Cairns, Lillian Barra
OBJECTIVES: The majority of rheumatoid arthritis (RA) patients express anti-citrullinated protein antibodies (ACPA). Unaffected first-degree relatives of RA patients (FDR) also express ACPA, commonly of the IgA isotype. IgG anti-homocitrullinated/carbamylated protein antibodies (AHCPA) have been detected in both RA and FDR. It is unknown whether other isotypes are expressed. We aim to investigate the AHCPA isotype profile in unaffected FDR of RA patients. METHODS: The enrolled subjects were examined by a rheumatologist...
June 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28592200/anti-carbamylated-protein-antibodies-in-systemic-lupus-erythematosus-patients-with-articular-involvement
#9
L Massaro, F Ceccarelli, T Colasanti, M Pendolino, C Perricone, E Cipriano, F Natalucci, G Capalbo, R Lucchetti, A Pecani, M Vomero, R Mancini, F R Spinelli, C Alessandri, G Valesini, F Conti
Objective Several studies have evaluated the prevalence of rheumatoid factor (RF) and anti-citrullinated proteins antibodies (ACPA) in systemic lupus erythematosus (SLE) patients but no data are available on the anti-carbamylated proteins (anti-CarP), a new biomarker for rheumatoid arthritis (RA). We evaluated the anti-CarP prevalence in SLE patients with joint involvement and the associations with different phenotypes. Methods Seventy-eight SLE patients with joint involvement were enrolled (F/M 73/5; mean ± SD age 47...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28582758/rheumatoid-arthritis-recent-advances-on-its-etiology-role-of-cytokines-and-pharmacotherapy
#10
REVIEW
Javaid Alam, Ibrahim Jantan, Syed Nasir Abbas Bukhari
An autoimmune disease is defined as a clinical syndrome resulted from an instigation of both T cell and B cell or individually, in the absence of any present infection or any sort of distinguishable cause. Clonal deletion of auto reactive cells remains the central canon of immunology for decades, keeping the role of T cell and B cell aside, which are actually the guards to recognize the entry of foreign body. According to NIH, 23.5 million Americans are all together affected by these diseases. They are rare, but with the exception of RA...
June 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28569212/the-prevalence-of-acpa-is-lower-in-rheumatoid-arthritis-patients-with-an-older-age-of-onset-but-the-composition-of-the-acpa-response-appears-identical
#11
Debbie M Boeters, Lukas Mangnus, Sofia Ajeganova, Elisabet Lindqvist, Björn Svensson, René E M Toes, Leendert A Trouw, Tom W J Huizinga, Francis Berenbaum, Jacques Morel, Solbritt Rantapää-Dahlqvist, Annette H M van der Helm-van Mil
BACKGROUND: Rheumatoid arthritis (RA) consists of two syndromes, one autoantibody-positive and one autoantibody-negative. Existing data on the relation between age of onset and prevalence of autoantibodies were conflicting. Therefore this multicohort study assessed the age of onset in relation to the presence of autoantibodies. The association with characteristics of the anti-citrullinated protein antibodies (ACPA) response was also explored. METHODS: The 1987 criteria-positive RA patients included in the Leiden EAC, BARFOT, ESPOIR, Umeå and Lund cohorts (n = 3321) were studied at presentation for age of onset and the presence of ACPA, rheumatoid factor (RF) and anti-carbamylated protein (anti-CarP) antibodies...
May 31, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28560470/cost-per-response-for-abatacept-versus-adalimumab-in-rheumatoid-arthritis-by-acpa-subgroups-in-germany-italy-spain-us-and-canada
#12
Laure Weijers, Christoph Baerwald, Francesco S Mennini, José M Rodríguez-Heredia, Martin J Bergman, Denis Choquette, Kirsten H Herrmann, Giulia Attinà, Carmela Nappi, Silvia Jimenez Merino, Chad Patel, Mondher Mtibaa, Jason Foo
Rheumatoid arthritis (RA) is a chronic inflammatory disorder leading to disability and reduced quality of life. Effective treatment with biologic DMARDs poses a significant economic burden. The Abatacept versus Adalimumab Comparison in Biologic-Naïve RA Subjects with Background Methotrexate (AMPLE) trial was a head-to-head, randomized study comparing abatacept in serum anti-citrullinated protein antibody (ACPA)-positive patients, with increasing efficacy across ACPA quartile levels. The aim of this study was to evaluate the cost per response accrued using abatacept versus adalimumab in ACPA-positive and ACPA-negative patients with RA from the health care perspective in Germany, Italy, Spain, the US and Canada...
May 30, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28555277/association-between-anti-porphyromonas-gingivalis-antibody-anti-citrullinated-protein-antibodies-and-rheumatoid-arthritis-a%C3%A2-meta-analysis
#13
S-C Bae, Y H Lee
OBJECTIVE: The aim of this study was to determine the relationship between anti-Porphyromonas gingivalis (anti-P. gingivalis) antibody levels and rheumatoid arthritis (RA) and its correlation with anti-citrullinated protein antibodies (ACPA). METHODS: We performed a meta-analysis of studies comparing (a) anti-P. gingivalis antibody levels in RA patients and healthy controls and (b) the correlation coefficients between the anti-P. gingivalis antibody levels and ACPA in RA patients...
May 29, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28545441/association-between-antibodies-to-carbamylated-proteins-and-subclinical-atherosclerosis-in-rheumatoid-arthritis-patients
#14
Francesca Romana Spinelli, Arbi Pecani, Francesco Ciciarello, Tania Colasanti, Manuela Di Franco, Francesca Miranda, Fabrizio Conti, Guido Valesini, Cristiano Alessandri
BACKGROUND: Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune system contributes to the development of atherosclerosis. Moreover, post-translational modifications such as citrullination and carbamylation have been linked to inflammation and atherosclerosis. Anti-carbamylated proteins antibodies (anti-CarP) are a new subset of autoantibodies identified in RA patients...
May 25, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28526580/biomarkers-for-rheumatoid-arthritis-from-molecular-processes-to-diagnostic-applications-current-concepts-and-future-perspectives
#15
REVIEW
Britt Nakken, Gábor Papp, Vidar Bosnes, Margit Zeher, György Nagy, Peter Szodoray
Early diagnosis and immediately started appropriate treatment are mandatory for the prevention of radiographic progression, functional disability and unfavourable disease outcome in rheumatoid arthritis (RA). The current classification criteria for RA include two different types of biomarkers representing inflammatory processes, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) or immune processes including autoantibodies, such as rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA)...
May 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28525857/industrial-air-emissions-and-proximity-to-major-industrial-emitters-are-associated-with-anti-citrullinated-protein-antibodies
#16
Sasha Bernatsky, Audrey Smargiassi, Lawrence Joseph, Phillip Awadalla, Ines Colmegna, Marie Hudson, Marvin J Fritzler
OBJECTIVE: To determine the association of anti-citrullinated antibodies (ACPA) with the ambient air pollutants fine particulate matter (PM2.5) and sulfur dioxide (SO2). METHODS: The CARTaGENE first-wave cohort includes 20,000 general population subjects from Quebec (Canada). On a sample of unselected 1586 subjects, we determined serum, ACPA and performed multivariable logistic regression, for the outcome of positive ACPA, assessing for independent effects of our air pollution variables, adjusting for age, sex, smoking, and French Canadian origin...
August 2017: Environmental Research
https://www.readbyqxmd.com/read/28516880/abatacept-therapy-reduces-cd28-cxcr5-follicular-helper-like-t-cells-in-patients-with-rheumatoid-arthritis
#17
Shunsuke Fukuyo, Shingo Nakayamada, Shigeru Iwata, Satoshi Kubo, Kazuyoshi Saito, Yoshiya Tanaka
OBJECTIVES: The characteristics of T cells targeted by abatacept (ABT) in cases of rheumatoid arthritis (RA) are still unknown. The goal of the study was to determine the pathogenicity of T cells and the predictors of therapeutic effects of ABT. METHODS: We analysed the peripheral T cell phenotype of 34 RA patients via flow cytometry. The correlation of the phenotypes of CD4+ T cells with clinical disease activity and change in CD4+ T cell subsets at baseline and 24 weeks after ABT treatment were evaluated...
April 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28507178/anti-carbamylated-protein-antibodies-are-detectable-in-various-connective-tissue-diseases
#18
Shuichiro Nakabo, Hajime Yoshifuji, Motomu Hashimoto, Yoshitaka Imura, Ran Nakashima, Kosaku Murakami, Nobuo Kuramoto, Shinji Ito, Junko Satoh, Masao Tanaka, Takao Fujii, Tsuneyo Mimori, Koichiro Ohmura
OBJECTIVE: Anti-carbamylated protein (anti-CarP) antibodies are possible diagnostic biomarkers of anticitrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA). We aimed to elucidate the prevalence of anti-CarP antibodies in non-RA connective tissue diseases (CTD) because CTD are important in the differential diagnosis of ACPA-negative RA. METHODS: The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA...
May 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28505163/anti-citrullinated-peptide-antibodies-are-the-strongest-predictor-of-clinically-relevant-radiographic-progression-in-rheumatoid-arthritis-patients-achieving-remission-or-low-disease-activity-a-post-hoc-analysis-of-a-nationwide-cohort-in-japan
#19
Tomohiro Koga, Akitomo Okada, Takaaki Fukuda, Toshihiko Hidaka, Tomonori Ishii, Yukitaka Ueki, Takao Kodera, Munetoshi Nakashima, Yuichi Takahashi, Seiyo Honda, Yoshiro Horai, Ryu Watanabe, Hiroshi Okuno, Toshiyuki Aramaki, Tomomasa Izumiyama, Osamu Takai, Taiichiro Miyashita, Shuntaro Sato, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Hideki Nakamura, Kiyoshi Aoyagi, Katsumi Eguchi, Atsushi Kawakami
OBJECTIVES: To determine prognostic factors of clinically relevant radiographic progression (CRRP) in patients with rheumatoid arthritis (RA) achieving remission or low disease activity (LDA) in clinical practice. METHODS: Using data from a nationwide, multicenter, prospective study in Japan, we evaluated 198 biological disease-modifying antirheumatic drug (bDMARD)-naïve RA patients who were in remission or had LDA at study entry after being treated with conventional synthetic DMARDs (csDMARDs)...
2017: PloS One
https://www.readbyqxmd.com/read/28487154/long-term-mortality-in-patients-with-st-segment-elevation-myocardial-infarction-is-associated-with-anti-citrullinated-protein-antibodies
#20
Maaike P J Hermans, Daniel van der Velden, José M Montero Cabezas, Hein Putter, Tom W J Huizinga, Johan Kuiper, Rene E M Toes, Martin J Schalij, J Wouter Jukema, Diane van der Woude
BACKGROUND: Cardiovascular (CV) mortality is higher in patients with rheumatoid arthritis (RA), in particular when anti-citrullinated protein antibodies (ACPA) are present. Recently, ACPA have also been described in a cohort of patients without RA, but with coronary artery disease (CAD). It is however unknown if ACPA can consistently be found in patients with CAD, and if ACPA are associated with mortality in these patients. The purpose of this study was to assess the relationship between ACPA and long-term outcomes including mortality in patients with ST-elevation myocardial infarction (STEMI) without RA...
April 25, 2017: International Journal of Cardiology
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