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https://www.readbyqxmd.com/read/29141000/soluble-glycoprotein-vi-a-specific-marker-of-platelet-activation-is-increased-in-the-plasma-of-subjects-with-seropositive-rheumatoid-arthritis
#1
John R Stack, Anne Madigan, Laura Helbert, Eimear Dunne, Elizabeth E Gardiner, Robert K Andrews, Roisin Finan, Elizabeth Smyth, Dermot Kenny, Geraldine M McCarthy
OBJECTIVES: Anti-citrullinated protein antibodies (ACPA) have been shown to cause platelet activation in vitro, through the low-affinity immunoglobulin G (IgG) receptor (FcγRIIa) on platelets. Platelet activation via engagement of FcγRIIa results in proteolytic cleavage and shedding of platelet specific glycoprotein VI (GPVI) which can be detected in the plasma as soluble GPVI (sGPVI). We hypothesized that plasma levels of sGPVI would be increased among patients with seropositive RA as a consequence of antibody-induced platelet activation and GPVI shedding...
2017: PloS One
https://www.readbyqxmd.com/read/29128791/acpa-and-jwh-133-modulate-the-vascular-tone-of-superior-mesenteric-arteries-through-cannabinoid-receptors-bkca-channels-and-nitric-oxide-dependent-mechanisms
#2
Evelyn López-Dyck, Felipa Andrade-Urzúa, Alejandro Elizalde, Tania Ferrer-Villada, Adan Dagnino-Acosta, Miguel Huerta, Zyanya Osuna-Calleros, Cinthia Rangel-Sandoval, Enrique Sánchez-Pastor
BACKGROUND: Some cannabinoids, a family of compounds derived from Cannabis sativa (marijuana), have previously shown vasodilator effects in several studies, a feature that makes them suitable for the generation of a potential treatment for hypertension. The mechanism underlying this vasodilator effect in arteries is still controversial. In this report, we explored how the synthetic cannabinoids ACPA (CB1-selective agonist) and JWH-133 (CB2-selective agonist) regulate the vascular tone of rat superior mesenteric arteries...
July 1, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128424/the-use-of-synthetic-peptides-for-detection-of-anti-citrullinated-protein-antibodies-in-rheumatoid-arthritis
#3
Nicole Hartwig Trier, Bettina Eide Holm, Julie Heiden, Ole Slot, Henning Locht, Bente Jensen, Hanne Lindegaard, Anders Svendsen, Christoffer Tandrup Nielsen, Søren Jacobsen, Elke Theander, Gunnar Houen
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. A characteristic feature of RA is the presence of anti-citrullinated protein antibodies (ACPA). Since ACPAs are highly specific for RA and are often present before the onset of RA symptoms, they have become valuable diagnostic and prognostic. As a result, several assays for detection of ACPAs exist, which vary in sensitivity and specificity. In this study, we analyzed the reactivity of RA sera to selected peptides by solid-phase immunoassays in order to develop an ACPA assay with improved sensitivity and specificity...
November 8, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29122245/methods-for-segmentation-of-rheumatoid-arthritis-bone-erosions-in-high-resolution-peripheral-quantitative-computed-tomography-hr-pqct
#4
Camille P Figueiredo, Arnd Kleyer, David Simon, Fabian Stemmler, Isabelle d'Oliveira, Anja Weissenfels, Oleg Museyko, Andreas Friedberger, Axel J Hueber, Judith Haschka, Matthias Englbrecht, Rosa M R Pereira, Juergen Rech, Georg Schett, Klaus Engelke
OBJECTIVE: The comparison between different techniques to quantify the 3-dimensional size of inflammatory bone erosions in rheumatoid arthritis(RA) patients. METHODS: Anti-cyclic citrullinated peptide antibody(ACPA) positive RA patients received high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the metacarpophalangeal joints (MCP). Erosions were measured by three different segmentation techniques: (1) manual method with calculation by half-ellipsoid formula, (2) semi-automated modified Evaluation Script for Erosions (mESE), and (3) semi-automated Medical Image Analysis Framework (MIAF) software...
September 23, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29109281/peptidyl-arginine-deiminase-immunization-induces-anticitrullinated-protein-antibodies-in-mice-with-particular-mhc-types
#5
Fanny Arnoux, Charlotte Mariot, Elisa Peen, Nathalie C Lambert, Nathalie Balandraud, Jean Roudier, Isabelle Auger
Autoantibodies to citrullinated proteins (ACPAs) are present in two-thirds of patients with rheumatoid arthritis (RA). ACPAs are produced in the absence of identified T cell responses for each citrullinated protein. Peptidyl arginine deiminase 4 (PAD4), which binds proteins and citrullinates them, is the target of autoantibodies in early RA. This suggests a model for the emergence of ACPAs in the absence of detectable T cells specific for citrullinated antigens: ACPAs could arise because PADs are recognized by T cells, which help the production of autoantibodies to proteins bound by PADs, according to a "hapten/carrier" model...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29107616/chronic-pain-disrupts-ability-to-work-by-interfering-with-social-function-a-cross-sectional-study
#6
Elizabeth Hengstebeck, Steven Roskos, Karen Breejen, Bengt Arnetz, Judy Arnetz
BACKGROUND AND AIMS: Some 100 million adults in the United States suffer from chronic pain. While research to date has focused primarily on pain interference with physical and psychological function and its effects on employment, few studies have examined the impact of pain interference on social functioning and its effects on employment. The aims of our study were to (1) evaluate the association between pain interference with ability to work and actual employment status among working age adults with chronic pain; and (2) evaluate pain interference with four types of functioning - cognitive, physical, psychological, and social - as possible mediators of pain interference with the ability to work...
October 26, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29106059/increased-levels-of-neutrophil-extracellular-trap-remnants-in-the-serum-of-patients-with-rheumatoid-arthritis
#7
Wei Wang, Wanchan Peng, Xingwang Ning
AIMS: Neutrophil extracellular traps (NETs) comprise a unique form of non-apoptotic cell death exhibited by neutrophils, which occurs in a stepwise process termed NETosis. It has been postulated that NETosis plays an important role in the pathogenesis of autoimmune disorders. The aim of this study was to evaluate serum levels of NET remnants in patients with rheumatoid arthritis (RA), as well as potential associations between NET remnants and indicators of RA. METHODS: Serum levels of myeloperoxidase (MPO)-DNA complexes (NET remnants) were examined in 74 RA patients and 50 healthy controls using a modified enzyme-linked immunosorbent assay...
November 6, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29100671/-nettling-the-host-breaking-of-tolerance-in-chronic-inflammation-and-chronic-infection
#8
REVIEW
Sladjana Skopelja-Gardner, Jonathan D Jones, William F C Rigby
How and why we break tolerance to self-proteins still remains a largely unanswered question. Neutrophils have been identified as a rich source of autoantigens in a wide array of autoimmune diseases that arise as a consequence of different environmental and genetic factors, e.g. rheumatoid arthritis (RA), lupus, vasculitis, cystic fibrosis (CF) etc. Specifically, neutrophil extracellular trap (NET) formation has been identified as a link between innate and adaptive immune responses in autoimmunity. Autoantigens including neutrophil granular proteins (targeted by anti-neutrophil cytoplasmic antibodies, ANCA) as well as post-translationally modified proteins, i...
October 31, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29096669/anti-carbamylated-protein-antibodies-precede-disease-onset-in-monkeys-with-collagen-induced-arthritis
#9
Marije K Verheul, Michel P M Vierboom, Bert A 't Hart, Rene E M Toes, Leendert A Trouw
BACKGROUND: Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have also been described in rodent models of arthritis, while ACPA are not consistently detectable. Data on these RA-associated autoantibodies in primates are not available. Therefore, we investigated the presence of RF, anti-CarP antibodies and ACPA in rhesus monkeys before and after collagen-induced arthritis immunizations...
November 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29084415/association-of-distinct-fine-specificities-of-anti-citrullinated-peptide-antibodies-with-elevated-immune-responses-to-prevotella-intermedia-in-a-subgroup-of-patients-with-rheumatoid-arthritis-and-periodontitis
#10
Anja Schwenzer, Anne-Marie Quirke, Anna M Marzeda, Alicia Wong, Anna B Montgomery, Harlan R Sayles, Sigrun Eick, Katarzyna Gawron, Maria Chomyszyn-Gajewska, Katarzyna Łazarz-Bartyzel, Simon Davis, Jan Potempa, Benedikt M Kessler, Roman Fischer, Patrick J Venables, Jeffrey B Payne, Ted R Mikuls, Kim S Midwood
OBJECTIVE: In addition to the long-established link with smoking, periodontitis (PD) is a risk factor for rheumatoid arthritis (RA). This study was undertaken to elucidate the mechanism by which PD could induce antibodies to citrullinated peptides (ACPAs), by examining the antibody response to a novel citrullinated peptide of cytokeratin 13 (CK-13) identified in gingival crevicular fluid (GCF), and comparing the response to 4 other citrullinated peptides in patients with RA who were well-characterized for PD and smoking...
October 30, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29070529/anticitrullinated-protein-peptide-antibody-multiplexing-defines-an-extended-group-of-acpa-positive-rheumatoid-arthritis-patients-with-distinct-genetic-and-environmental-determinants
#11
Johan Rönnelid, Monika Hansson, Linda Mathsson-Alm, Martin Cornillet, Evan Reed, Per-Johan Jakobsson, Lars Alfredsson, Rikard Holmdahl, Karl Skriner, Guy Serre, Karin Lundberg, Lars Klareskog
INTRODUCTION: The second generation anticycliccitrullinated peptide (anti-CCP2) assay detects the majority but not all anticitrullinated protein/peptide antibodies (ACPA). Anti-CCP2-positive rheumatoid arthritis (RA) is associated with HLA-DRB1* shared epitope (SE) alleles and smoking. Using a multiplex assay to detect multiple specific ACPA, we have investigated the fine specificity of individual ACPA responses and the biological impact of additional ACPA reactivity among anti-CCP2-negative patients...
October 25, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29057725/prevalence-of-nasal-colonization-with-staphylococcus-aureus-in-patients-with-rheumatoid-arthritis
#12
Gloria Albert, Milagros Ricse, Javier Narvaez, Jesus Rodriguez, Joan Miquel Nolla, Mari Angeles Dominguez-Luzon, Carmen Gomez Vaquero
OBJECTIVE: Patients with rheumatoid arthritis (RA) and nasal carriers of Staphylococcus aureus have an increased risk of developing infections caused by S. aureus. Our objective was to determine the prevalence of S. aureus nasal colonization in patients with RA and its relationship to RA treatments. METHODS: Two hundred seven patients with RA and 37 healthy controls were prospectively included in a cross-sectional study. A nasal secretion sample was collected by swab from both anterior nostrils and was referred to the hospital's microbiology department for culturing...
October 20, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29033912/the-infectious-basis-of-acpa-positive-rheumatoid-arthritis
#13
REVIEW
Lazaros I Sakkas, Dimitrios Daoussis, Stamatis-Nick Liossis, Dimitrios P Bogdanos
Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA. There are strong data for three infectious agents as autoimmunity triggers in RA, namely Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans causes of periodontal disease (PD), and Epstein-Barr virus (EBV). P. gingivalis expresses arginine gingipains, that cleave proteins at the arginine residues, and peptidyl arginine deiminase (PPAD), which citrullinates arginine residues of proteins, thus forming neoantigens that lead to ACPA production...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29032058/cross-state-dependency-of-learning-between-arachidonylcyclopropylamide-acpa-and-muscimol-in-the-mouse-dorsal-hippocampus
#14
Majid Jafari-Sabet, Amir-Mohammad Karimi
The aim of the present study was to examine cross state-dependent learning between ACPA (a selective cannabinoid CB1 receptor agonist) and muscimol (a selective GABAA receptor agonist) in the step-down inhibitory avoidance learning task. The dorsal hippocampal CA1 regions of adult male NMRI mice were bilaterally cannulated, and all drugs were microinjected into the intended sites of injection. Post-training and/or pre-test administration of ACPA (1 and 2ng/mouse) dose-dependently induced amnesia. Pre-test microinjection of the same doses of ACPA reversed the post-training ACPA-induced amnesia...
October 13, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29029341/an-increased-concentration-of-receptor-activator-of-nuclear-factor-kappa-b-ligand-pre-dates-the-onset-of-rheumatoid-arthritis
#15
Linda Johansson, Lisbeth Ärlestig, Heidi Kokkonen, Mikael Brink, Solbritt Rantapää-Dahlqvist
Objectives: RANK ligand (RANKL) is involved in destruction and osteoporosis in RA. In this study, the relationships between RANKL and ACPA, anti-carbamylated protein antibodies (anti-CarP), cytokines and chemokines were analysed in individuals before the onset of RA symptoms, and their associations with radiological findings at disease onset were assessed. Methods: This was a case-control study performed within the Medical Biobank of Northern Sweden that included 470 pre-symptomatic individuals [334 women and 136 men; mean (s...
September 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/29025870/genetic-landscape-of-interactive-effects-of-hla-drb1-alleles-on-susceptibility-to-acpa-rheumatoid-arthritis-and-acpa-levels-in-japanese-population
#16
Chikashi Terao, Yukinori Okada, Katsunori Ikari, Yuta Kochi, Akari Suzuki, Koichiro Ohmura, Keitaro Matsuo, Atsuo Taniguchi, Michiaki Kubo, Soumya Raychaudhuri, Kazuhiko Yamamoto, Hisashi Yamanaka, Yoichiro Kamatani, Tsuneyo Mimori, Fumihiko Matsuda
BACKGROUND: HLA-DRB1 is the strongest susceptibility gene to rheumatoid arthritis (RA). HLA-DRB1 alleles showed significant non-additive and interactive effects on susceptibility to RA in the European population, but these effects on RA susceptibility should vary between populations due to the difference in allelic distribution. Furthermore, non-additive or interactive effects on the phenotypes of RA are not fully known. We evaluated the non-additive and interactive effects of HLA-DRB1 alleles on RA susceptibility and anticitrullinated protein/peptide antibody (ACPA) levels in Japanese patients...
October 12, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28980908/serum-il-7-as-diagnostic-biomarker-for-rheumatoid-arthritis-validation-with-eular-2010-classification-criteria
#17
Agata N Burska, Jessica Neilan, Ruth E Chisman, Rujiraporn Pitaksalee, Richard Hodgett, Helena Marzo-Ortega, Philip G Conaghan, Robert West, Paul Emery, Frederique Ponchel
OBJECTIVES: Despite the well-established value of currently used classification criteria for the early diagnosis of rheumatoid arthritis (RA) there is a constant demand for novel biomarkers notably in autoantibody-negative patients. Interleukin 7 (IL-7) has been reported as a candidate diagnostic biomarker based on ACR-1987 criteria. However, clinical practice has moved to using the EULAR 2010 classification criteria. Therefore, to advance the use of IL-7 alongside the RA biomarker pipeline, we repeated the original study in a new cohort...
September 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28977504/rheumatoid-factors-do-not-preferentially-bind-to-acpa-igg-or-igg-with-altered-galactosylation
#18
Willem J J Falkenburg, Ayla C Kempers, Gillian Dekkers, Pleuni Ooijevaar-de Heer, Arthur E H Bentlage, Gestur Vidarsson, Dirkjan van Schaardenburg, René E M Toes, Hans U Scherer, Theo Rispens
Objectives: Recent reports describe interactions between the two most prominent RA-related autoantibodies, RFs and ACPAs. The main aim of the present study was to investigate whether RFs preferentially interact with ACPA-IgG over non-ACPA IgG. Additionally, interactions of RFs with IgG with altered galactose content in the Fc domain were examined, since ACPA-IgGs have been shown to have decreased Fc galactose content in RF+ patients. Methods: (Auto)antibody interactions were studied in a surface plasmon resonance imaging assay and with ELISA...
November 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28970207/clinical-and-radiological-outcomes-of-5-year-drug-free-remission-steered-treatment-in-patients-with-early-arthritis-improved-study
#19
Gülşah Akdemir, Lotte Heimans, Sytske Anne Bergstra, Robbert J Goekoop, Maikel van Oosterhout, Johannes H L M van Groenendael, André J Peeters, Gerda M Steup-Beekman, Leroy R Lard, Peter B J de Sonnaville, Bernard A M Grillet, Tom W J Huizinga, Cornelia F Allaart
OBJECTIVES: To determine the 5-year outcomes of early remission induction therapy followed by targeted treatment aimed at drug-free remission (DFR) in patients with early arthritis. METHODS: In 12 hospitals, 610 patients with early (<2 years) rheumatoid arthritis (RA) or undifferentiated arthritis (UA) started on methotrexate (MTX) 25 mg/week and prednisone (60 mg/day tapered to 7.5 mg/day). Patients not in early remission (Disease Activity Score <1...
September 28, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28968865/the-risk-of-individual-autoantibodies-autoantibody-combinations-and-levels-for-arthritis-development-in-clinically-suspect-arthralgia
#20
Robin M Ten Brinck, Hanna W van Steenbergen, Myrthe A M van Delft, Marije K Verheul, Rene E M Toes, Leendert A Trouw, Annette H M van der Helm-van Mil
Objectives: Autoantibody testing is helpful for predicting the risk of progression to clinical arthritis in subjects at risk. Previous longitudinal studies have mainly selected autoantibody-positive arthralgia patients, and consequently the predictive values of autoantibodies were evaluated relative to one another. This study assessed the risks for arthritis development of ACPA, RF and/or anti-carbamylated protein antibodies (anti-CarP) in arthralgia patients considered at risk for RA by rheumatologists, based on clinical characteristics (clinically suspect arthralgia, CSA)...
September 11, 2017: Rheumatology
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