keyword
MENU ▼
Read by QxMD icon Read
search

ACPA

keyword
https://www.readbyqxmd.com/read/28931878/a-method-to-identify-trace-sulfated-igg-n-glycans-as-biomarkers-for-rheumatoid-arthritis
#1
Jing-Rong Wang, Wei-Na Gao, Rudolf Grimm, Shibo Jiang, Yong Liang, Hua Ye, Zhan-Guo Li, Lee-Fong Yau, Hao Huang, Ju Liu, Min Jiang, Qiong Meng, Tian-Tian Tong, Hai-Hui Huang, Stephanie Lee, Xing Zeng, Liang Liu, Zhi-Hong Jiang
N-linked glycans on immunoglobulin G (IgG) have been associated with pathogenesis of diseases and the therapeutic functions of antibody-based drugs; however, low-abundance species are difficult to detect. Here we show a glycomic approach to detect these species on human IgGs using a specialized microfluidic chip. We discover 20 sulfated and 4 acetylated N-glycans on IgGs. Using multiple reaction monitoring method, we precisely quantify these previously undetected low-abundance, trace and even ultra-trace N-glycans...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28919520/antibodies-against-citrullinated-alpha-enolase-peptides-in-primary-sjogren-s-syndrome
#2
Adrianos Nezos, Ilir Cinoku, Clio P Mavragani, Haralampos M Moutsopoulos
Citrullinated alpha enolase (CEP-1) has been designated as a major antigenic target of antibodies against citrullinated proteins (ACPA) in patients with rheumatoid arthritis (RA). Our aim is to determine the prevalence of anti-CEP-1 in a cohort of ACPA positive (ACPA+) primary Sjogren's syndrome (pSS) patients. Anti-CEP1 titers were determined by ELISA in sera from 15 ACPA+ and 45 ACPA- age/sex matched pSS; 12 ACPA+ RA patients and 30 healthy controls (HC). Increased anti-CEP-1 antibody titers were detected in nine out of the 15 (60%) ACPA+ pSS patients and 5 out of 12 (41...
September 14, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28912623/measurement-of-serum-klotho-in-systemic-sclerosis
#3
Rossella Talotta, Sara Bongiovanni, Teresa Letizia, Federica Rigamonti, Maria Chiara Ditto, Fabiola Atzeni, Fausto Salaffi, Alberto Batticciotto, Maria Chiara Gerardi, Marco Antivalle, Tarcisio Vago, Maurizio Benucci, Piercarlo Sarzi-Puttini
BACKGROUND: The aim of our study was to evaluate the serum concentration of klotho in a cohort of systemic sclerosis (SSc) patients compared to that of healthy controls and to correlate its levels with the degree and the kind of organ involvement. METHODS: Blood samples obtained from both patients and controls were collected and analysed by an ELISA test for the determination of human soluble klotho. Scleroderma patients were evaluated for disease activity through clinical, laboratory, and instrumental assessment...
2017: Disease Markers
https://www.readbyqxmd.com/read/28899798/is-acpa-positivity-the-main-driver-for-rheumatoid-arthritis-treatment-pros-and-cons
#4
REVIEW
Stefano Alivernini, Mauro Galeazzi, Hagit Peleg, Barbara Tolusso, Elisa Gremese, Gianfranco Ferraccioli, Yaakov Naparstek
Rheumatoid Arthritis (RA) is an autoimmune chronic disease that is characterized by the positivity of various antibodies, the most specific being autoantibodies against citrullinated antigens (ACPA). Despite ACPA are not arthritogenic by themselves, ACPA positive individuals have high risk of RA development and ACPA positivity is associated with severe erosive phenotype and higher mortality rate compared to seronegative RA. Moreover, ACPA status is associated with favorable response to biologics targeting pathways involving autoantibody producing cells as B lymphocytes...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28882619/variable-domain-glycosylation-of-acpa-igg-a-missing-link-in-the-maturation-of-the-acpa-response
#5
Ayla C Kempers, Lise Hafkenscheid, Hans Ulrich Scherer, René E M Toes
Anti-citrullinated Protein Antibodies (ACPA) are excellent markers for Rheumatoid arthritis (RA) and are postulated to have a pathogenic role in the disease process. A multistep model for the evolution of the ACPA response in RA was proposed in which an initial break of tolerance causes, as "first hit", "silent" production of ACPA without any clinical symptoms. The model further proposes that the ACPA immune response matures upon a certain (unknown) trigger, a "second hit", which leads to epitope spreading, an increase in ACPA titres and extended isotype usage before clinical RA manifestations...
September 4, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28879055/working-in-cold-environment-and-risk-of-developing-rheumatoid-arthritis-results-from-the-swedish-eira-case-control-study
#6
Pingling Zeng, Camilla Bengtsson, Lars Klareskog, Lars Alfredsson
OBJECTIVES: To investigate (1) whether working in cold environment (WCE) is associated with an increased risk of developing rheumatoid arthritis (RA) (overall), anticitrullinated protein antibody (ACPA)-positive RA and ACPA-negative RA and (2) whether WCE interacts with occupational physical workload in conferring RA risk. METHODS: Data from the Swedish population-based case-control study Epidemiological Investigation of Rheumatoid Arthritis involving 3659 incident cases and 5925 controls were analysed...
2017: RMD Open
https://www.readbyqxmd.com/read/28859327/female-hormonal-factors-and-the-development-of-anti-citrullinated-protein-antibodies-in-women-at-risk-of-rheumatoid-arthritis
#7
Deshiré Alpizar-Rodriguez, Rüdiger B Mueller, Burkhard Möller, Jean Dudler, Adrian Ciurea, Pascal Zufferey, Diego Kyburz, Ulrich A Walker, Ines von Mühlenen, Pascale Roux-Lombard, Michael Mahler, Celine Lamacchia, Delphine S Courvoisier, Cem Gabay, Axel Finckh
Objectives: To analyse the association between female hormonal factors and the development of systemic autoimmunity associated with RA in women at increased risk for RA, namely first-degree relatives of patients with RA (RA-FDRs). Methods: In an ongoing cohort study of RA-FDRs, we analysed all women with available ACPA status. The primary outcome was ACPA positivity. The predictors of interest were female hormonal factors, such as oral contraceptives, breastfeeding, post-menopausal status, early post-menopausal period and total number of ovulatory years...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28853240/anti-carbamylated-protein-antibodies-presence-in-early-arthritis-with-a-poorer-clinical-and-radiological-outcome-data-from-the-french-espoir-cohort
#8
Marie-Elise Truchetet, Stéphanie Dublanc, Thomas Barnetche, Olivier Vittecoq, Xavier Mariette, Christophe Richez, Patrick Blanco, Michael Mahler, Cécile Contin-Bordes, Thierry Schaeverbeke
OBJECTIVES: To assess the prevalence of anti-carbamylated protein (CarP) antibodies in a French cohort of early arthritis and to investigate their association with clinical features, final diagnosis, prognosis and comorbidities. METHODS: The presence of anti-CarP antibodies among patients with early arthritis belonging to the ESPOIR French cohort (n=720) was determined using ELISA. We calculated the prevalence of anti-CarP antibodies in different patient subgroups that were stratified according to their anti-citrullinated peptides antibodies (ACPA) and/or rheumatoid factor (RF) status...
August 29, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28853239/acpa-acarpa-and-rheumatoid-arthritis-azurophilic-granules-sing-the-blues
#9
EDITORIAL
William F C Rigby, Sladjana Skopelja-Gardner, Jonathan D Jones
Arginine and lysine are distinguished by their identity as the most cationic (basic) amino acids. They are also the target of many post-translational modifications, e.g. acetylation, citrullination, hydroxylation, methylation, ubiquitination. These modifications are catalyzed by a series of enzymes, presumably to enable a tapestry of functionality by a single protein, including regulation of DNA transcription, repair and replication. Besides their functional roles in normal physiological conditions, some of these protein modifications have been recognized as inflammatory triggers and targets of autoimmune reactions...
August 29, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28832223/local-bone-loss-in-patients-with-anti-citrullinated-peptide-antibody-and-arthralgia-evaluated-with-high-resolution-peripheral-quantitative-computed-tomography
#10
K K Keller, J S Thomsen, K Stengaard-Pedersen, A W Nielsen, B Schiøttz-Christensen, L Svendsen, M Graakjær, P M Petersen, B Unger, S G Kjær, B L Langdahl, E M Hauge
OBJECTIVE: To investigate bone changes in the metacarpophalangeal (MCP) joints of anti-citrullinated peptide antibody (ACPA)-positive patients with arthralgia, but not arthritis, compared to healthy controls. METHOD: Using a cross-sectional study design, patients were recruited from hospitals and private care rheumatologists, and controls from a test subject website. All subjects underwent medical history interview, clinical examination, and biochemical screening including ACPA...
August 23, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28826660/anti-citrullinated-peptide-antibodies-profiling-in-established-rheumatoid-arthritis
#11
Maria Laura Manca, Alessia Alunno, Claudia D'Amato, Onelia Bistoni, Ilaria Puxeddu, Roberto Gerli, Paola Migliorini, Federico Pratesi
OBJECTIVES: Anti-citrullinated protein/peptide antibodies (ACPA) represent an important tool for the diagnosis of rheumatoid arthritis (RA) and the presence of multiple ACPA specificities is highly correlated with the evolution towards RA. However, little is known about the association of single specificities with disease manifestations and response to therapy in established RA. The aim of this work is to evaluate in a retrospective study the clinico-serological association of ACPA detected using VCP1 and VCP2 (EBV-derived citrullinated peptides) and HCP1 and HCP2 (histone-H4-derived citrulinated peptides) in established RA...
August 4, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28818831/oral-contraceptives-breastfeeding-and-the-risk-of-developing-rheumatoid-arthritis-results-from-the-swedish-eira-study
#12
Cecilia Orellana, Saedis Saevarsdottir, Lars Klareskog, Elizabeth W Karlson, Lars Alfredsson, Camilla Bengtsson
OBJECTIVES: To study whether oral contraceptive (OC) use or breastfeeding (BF) influence the risk of rheumatoid arthritis (RA), stratifying the cases by presence/absence of anticitrullinated protein antibodies (ACPA), and whether these factors interact with known risk factors in the development of ACPA-positive RA. METHODS: Women aged ≥18 years, participants in the population-based case-control Swedish Epidemiological Investigation of RA study (2641 cases/4251 controls), completed an extensive questionnaire regarding OC, BF and potential confounders...
August 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28814366/porphyromonas-gingivalis-and-igg1-and-igg2-subclass-antibodies-in-patients-with-juvenile-idiopathic-arthritis
#13
Consuelo Romero-Sánchez, Clara Malagón, Camilo Vargas, María Fernanda Torres, Lorena Chila Moreno, Constanza Rodríguez, Diana Marcela Castillo, Juliette De Avila, Ángela Catalina Mosquera, Gloria Inés Lafaurie
PURPOSE: The purpose of this study was to evaluate the periodontal status and the presence and concentration of Porphyromonas gingivalis (P. gingivalis) and immunoglobulin G (IgG) subclass against P. gingivalis in juvenile idiopathic arthritis (JIA) and its association with rheumatic clinical activity parameters. METHODS: Rheumatologic conditions and periodontal status were clinically assessed in 51 patients with JIA. P. gingivalis, IgG1 and IgG2, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs), and human leukocyte antigen B27 were also evaluated...
May 15, 2017: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28810902/the-isotype-and-igg-subclass-distribution-of-anti-carbamylated-protein-antibodies-in-rheumatoid-arthritis-patients
#14
Myrthe A M van Delft, Marije K Verheul, Leonie E Burgers, Veerle F A M Derksen, Annette H M van der Helm-van Mil, Diane van der Woude, Tom W J Huizinga, René E M Toes, Leendert A Trouw
BACKGROUND: Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties. At present, the breadth and molecular make-up of the anti-CarP antibody response is ill defined. To understand the anti-CarP antibody immune response and potential immune effector mechanisms it can recruit, we determined the anti-CarP antibody isotype and IgG-subclass usage in RA patients...
August 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28802150/mir-let-7a-regulates-anti-citrullinated-protein-antibody-induced-macrophage-activation-and-correlates-with-the-development-of-experimental-rheumatoid-arthritis
#15
Wei Zhu, Jianbo Yu, Shou Qiu, Haifeng Liu, Yan Wang, Xiaoyan Xu, Lili Shao, Lingling Zhu, Yan Jiao, Fan Liu, Xiaodong Zhu
Anti-citrullinated protein antibodies (ACPAs) are a key serological marker of rheumatoid arthritis (RA). To investigate whether miR-let7a downregulated ACPA-induced macrophage activation and arthritis, miR-let7a levels were assessed in the synovial fluid from patients with RA or osteoarthritis (OA). In addition, expression of the pro-inflammatory genes HMGA2, PI3K, and IRF5 was examined in ACPA-induced macrophages and a collagen antibody-induced mouse model of arthritis. As expected, miR-let7a expression in synovial fluid macrophages was substantially lower in patients with RA than in those with OA...
August 9, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28801345/molecular-basis-for-increased-susceptibility-of-indigenous-north-americans-to-seropositive-rheumatoid-arthritis
#16
Stephen W Scally, Soi-Cheng Law, Yi Tian Ting, Jurgen van Heemst, Jeremy Sokolove, Aaron J Deutsch, E Bridie Clemens, Antonis K Moustakas, George K Papadopoulos, Diane van der Woude, Irene Smolik, Carol A Hitchon, David B Robinson, Elizabeth D Ferucci, Charles N Bernstein, Xiaobo Meng, Vidyanand Anaparti, Tom Huizinga, Katherine Kedzierska, Hugh H Reid, Soumya Raychaudhuri, René E Toes, Jamie Rossjohn, Hani El-Gabalawy, Ranjeny Thomas
OBJECTIVE: The pathogenetic mechanisms by which HLA-DRB1 alleles are associated with anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) are incompletely understood. RA high-risk HLA-DRB1 alleles are known to share a common motif, the 'shared susceptibility epitope (SE)'. Here, the electropositive P4 pocket of HLA-DRB1 accommodates self-peptide residues containing citrulline but not arginine. HLA-DRB1 His/Phe13β stratifies with ACPA-positive RA, while His13βSer polymorphisms stratify with ACPA-negative RA and RA protection...
August 11, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28795508/occupation-and-risk-of-developing-rheumatoid-arthritis-results-from-a-population-based-case-control-study
#17
Anna Ilar, Lars Alfredsson, Pernilla Wiebert, Lars Klareskog, Camilla Bengtsson
OBJECTIVE: Environmental factors are of importance for the etiology of rheumatoid arthritis (RA), but much remains unknown concerning the contributions from distinct occupational hazards. We explored the association between occupation and the risk of anti-citrullinated protein antibody (ACPA) + RA or ACPA- RA. METHODS: We analyzed 3,522 cases and 5,580 controls from the Swedish population-based EIRA case-control study. A questionnaire was used to obtain information on work history and lifestyle factors...
August 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28794511/rheumatoid-arthritis-acpa-specific-synovial-immunophenotypes
#18
Dario Ummarino
No abstract text is available yet for this article.
September 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28791449/incidence-of-inflammatory-joint-diseases-in-finland-results-from-a-population-based-epidemiological-study
#19
A Kononoff, L Arstila, P Pussinen, H Kautiainen, P Elfving, E Savolainen, H Niinisalo, J Rutanen, O Marjoniemi, O Kaipiainen-Seppänen
The objective of the study was to assess the incidence of inflammatory joint diseases and possible environmental factors contributing to their occurrence in a defined population in Finland. All rheumatologists practising in the Northern Savo rheumatological outpatient departments collected data on their newly diagnosed patients with an inflammatory joint disease in 2010. Antibodies to Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) were determined from patients with various arthritides...
August 8, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28777897/joint-distribution-and-2-year-outcome-in-347-patients-with-monoarthritis-of-less-than-16-weeks-duration
#20
Ellen Sauar Norli, Gina Hetland Brinkmann, Tore Kristian Kvien, Olav Bjørneboe, Anne Julsrud Haugen, Halvor Nygaard, Cathrine Thunem, Elisabeth Lie, Maria Dahl Mjaavatten
OBJECTIVE: To study the joint distribution and 2-year outcome of patients with recent-onset monoarthritis. METHODS: Adult patients with clinically apparent monoarthritis of ≤16 weeks' duration were included in a multi-center 2-year longitudinal study. Clinical characteristics, joint distribution, development of chronic inflammatory rheumatic disease (CIRD), as well as classification according to the 2010 ACR/EULAR classification criteria for rheumatoid arthritis (2010 RA criteria) were studied...
August 4, 2017: Arthritis Care & Research
keyword
keyword
10260
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"