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https://www.readbyqxmd.com/read/28098199/optogenetic-modulation-of-urinary-bladder-contraction-for-lower-urinary-tract-dysfunction
#1
Jae Hong Park, Jin Ki Hong, Ja Yun Jang, Jieun An, Kyu-Sung Lee, Tong Mook Kang, Hyun Joon Shin, Jun-Kyo Francis Suh
As current clinical approaches for lower urinary tract (LUT) dysfunction such as pharmacological and electrical stimulation treatments lack target specificity, thus resulting in suboptimal outcomes with various side effects, a better treatment modality with spatial and temporal target-specificity is necessary. In this study, we delivered optogenetic membrane proteins, such as channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR), to bladder smooth muscle cells (SMCs) of mice using either the Cre-loxp transgenic system or a viral transfection method...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097053/in-vitro-effect-of-direct-current-electrical-stimulation-on-rat-mesenchymal-stem-cells
#2
Sahba Mobini, Liudmila Leppik, Vishnu Thottakkattumana Parameswaran, John Howard Barker
BACKGROUND: Electrical stimulation (ES) has been successfully used to treat bone defects clinically. Recently, both cellular and molecular approaches have demonstrated that ES can change cell behavior such as migration, proliferation and differentiation. METHODS: In the present study we exposed rat bone marrow- (BM-) and adipose tissue- (AT-) derived mesenchymal stem cells (MSCs) to direct current electrical stimulation (DC ES) and assessed temporal changes in osteogenic differentiation...
2017: PeerJ
https://www.readbyqxmd.com/read/28096689/influence-of-exercise-on-visceral-pain-an-explorative-study-in-healthy-volunteers
#3
Laura Jgm van Weerdenburg, Christina Brock, Asbjørn Mohr Drewes, Harry van Goor, Marjan de Vries, Oliver Hg Wilder-Smith
BACKGROUND AND OBJECTIVES: Contradictory results have been found about the effect of different exercise modalities on pain. The aim of this study was to investigate the early effects of aerobic and isometric exercise on different types of experimental pain, including visceral pain, compared to an active control condition. METHODS: Fifteen healthy subjects (6 women, mean [standard deviation] age 25 [6.5] years) completed 3 interventions consisting of 20 minutes of aerobic cycling, 12 minutes of isometric knee extension and a deep breathing procedure as active control...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28094417/evaluation-of-proximal-and-distal-motor-nerve-conduction-using-the-electrical-root-stimulation-technique-in-the-femoral-and-obturator-nerves
#4
Cengiz Ünsal, Erkut Turan, Ömer G Dilek, Seyyid S Sabancı, Murat Sarıerler
OBJECTIVES: This study aimed to investigate the adaptability of the electrical root stimulation technique by achieving normative data from the obturator and femoral nerves of healthy dogs. METHODS: For this purpose, two stimulations and recordings were performed on both the obturator and femoral nerves in 40 dogs (22 males and 18 females). Electrical root stimulation was applied via monopolar needle electrodes between the sixth to seventh and fifth to sixth lumbar interarcuate spaces to the obturator and femoral nerves, respectively...
January 17, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28093928/functional-electrical-stimulation-therapy-for-severe-hemiplegia-randomized-control-trial-revisited
#5
Cesar Marquez-Chin, Shaghayegh Bagher, Vera Zivanovic, Milos R Popovic
BACKGROUND: Stroke is the leading cause of long-term disability. Stroke survivors seldom improve their upper-limb function when their deficit is severe, despite recently developed therapies. PURPOSE: This study aims to assess the efficacy of functional electrical stimulation therapy in improving voluntary reaching and grasping after severe hemiplegia. METHOD: A post hoc analysis of a previously completed randomized control trial ( clinicaltrials...
January 1, 2017: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/28093818/intraoperative-microstimulation-predicts-outcome-of-postoperative-macrostimulation-in-subthalamic-nucleus-deep-brain-stimulation-for-parkinson-s-disease
#6
Raja Mehanna, Andre G Machado, John E Connett, Faisal Alsaloum, Scott E Cooper
BACKGROUND: In deep brain stimulation (DBS) of the subthalamic nucleus for treatment of Parkinson's Disease, a commonly encountered stimulation side effect is involuntary muscle contractions from spread of electrical current to cortico-spinal and cortico-bulbar fibers in the internal capsule. During surgery, a variety of techniques, including microelectrode recording (MER), are used to avoid positioning the DBS electrode too close to the internal capsule. At some centers, MER includes stimulating through the microelectrode (microstimulation)...
January 17, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28093479/paired-stimulation-for-spike-timing-dependent-plasticity-in-primate-sensorimotor-cortex
#7
Stephanie C Seeman, Brian J Mogen, Eberhard E Fetz, Steve I Perlmutter
: Classic studies in vitro have described spike-timing dependent plasticity (STDP) at a synapse: the connection from neuron A to neuron B is strengthened (or weakened) when A fires before (or after) B within an optimal time window. Accordingly, more recent in vivo works have demonstrated behavioral effects consistent with an STDP mechanism; however many relied on single-unit recordings. The ability to modify cortical connections becomes useful in the context of injury when connectivity, and associated behavior, is compromised...
January 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28093476/muscarinic-acetylcholine-receptors-and-m-currents-underlie-efferent-mediated-slow-excitation-in-calyx-bearing-vestibular-afferents
#8
J Chris Holt, Paivi M Jordan, Anna Lysakowski, Amit Shah, Kathy Barsz, Donatella Contini
: Stimulation of vestibular efferent neurons excites calyx and dimorphic (CD) afferents. This excitation consists of fast and slow components that differ over 100-fold in activation kinetics and response duration. In turtle, efferent-mediated fast excitation arises in CD afferents when the predominant efferent neurotransmitter acetylcholine (ACh) activates calyceal nicotinic ACh receptors (nAChRs); however, it is unclear whether the accompanying efferent-mediated slow excitation is also attributed to cholinergic mechanisms...
January 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28093194/effects-of-neuromuscular-electrical-stimulation-during-hemodialysis-on-peripheral-muscle-strength-and-exercise-capacity-a-randomized-clinical-trial
#9
Ana Karla Vieira Brüggemann, Carolina Luana Mello, Tarcila Dal Pont, Deborah de Camargo Hizume Kunzler, Daniel Fernandes Martins, Franciane Bobinski, Wellington Pereira Yamaguti, Elaine Paulin
OBJECTIVE: To evaluate the effects of neuromuscular electrical stimulation of high and low frequency and intensity, performed during hemodialysis (HD), on physical function and inflammation markers in patients with chronic kidney disease (CKD). DESIGN: Randomized clinical trial SETTING: Hemodialysis clinic. PARTICIPANTS: 51 CKD patients were randomized into blocks of four by means of opaque envelopes. They were divided into a group of high frequency and intensity neuromuscular electrical stimulation (HG) and a group of low frequency and intensity neuromuscular electrical stimulation (LG)...
January 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28092622/electroencephalographic-changes-associated-with-non-invasive-nociceptive-stimulus-in-minimally-anaesthetised-dogs
#10
U Kaka, Y M Goh, L W Chean, H C Chen
Electroencephalography (EEG) has been reported as an objective, non-invasive and stress free technique for nociceptive studies. Electrical stimuli can be used to evaluate the efficacy of centrally acting agents. Peripheral nerve stimulator can be a good and cheap source of electric stimulus for studies of nociception, and studies evaluating analgesic effect of drugs under EEG. In this study suitability of peripheral nerve stimulator, and milliamperage for nociceptive studies under electroencephalography were evaluated...
December 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28089855/peripheral-electrical-stimulation-increases-corticomotor-excitability-and-enhances-the-rate-of-visuomotor-adaptation
#11
Simon J Summers, Siobhan M Schabrun, Welber Marinovic, Lucy S Chipchase
Peripheral electrical stimulation (PES) modulates corticomotor excitability but its effect on motor performance has not been thoroughly investigated. The purpose of this study was to assess whether increases and/or decreases in corticomotor excitability, induced by PES, influenced motor performance using a visuomotor adaptation task. Three PES interventions (motor stimulation, sensory stimulation or sham) were delivered to the first dorsal interosseous (FDI) in 30 healthy participants matched for age, gender and handedness...
January 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28089758/pupil-responses-and-pain-ratings-to-heat-stimuli-reliability-and-effects-of-expectations-and-a-conditioning-pain-stimulus
#12
James C Eisenach, Regina Curry, Carol A Aschenbrenner, Robert C Coghill, Timothy T Houle
BACKGROUND: The locus coeruleus (LC) signals salience to sensory stimuli and these responses can modulate the experience of pain stimuli. The pupil dilation response (PDR) to noxious stimuli is thought to be a surrogate for LC responses, but PDR response to Peltier-controlled noxious heat stimuli, the most commonly used method in experimental pain research, has not been described. NEW METHOD: Healthy volunteers were presented with randomly presented heat stimuli of 5 sec duration and provided pain intensity ratings to each stimulus...
January 12, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28089606/parasacral-transcutaneous-electrical-neural-stimulation-ptens-once-a-week-for-the-treatment-of-overactive-bladder-in-children-a-randomized-controlled-trial
#13
Lidyanne Ilidia da Silva de Paula, Liliana Fajardo de Oliveira, Brysa Paiva Cruz, Dayana Maria de Oliveira, Laís Maini Miranda, Mauro de Moraes Ribeiro, Raphaela Ornellas Duque, André Avarese de Figueiredo, José de Bessa, José Murillo Bastos Netto
INTRODUCTION: Overactive bladder (OAB) is the most prevalent voiding disorder in childhood, and its main manifestation is urinary urgency. In general, urotherapy and anticholinergics are the first choices of treatment. Parasacral Transcutaneous Electrical Neural Stimulation (PTENS) was introduced as an alternative for the treatment of detrusor overactivity in children, but treatment protocols described to date require several sessions per week or long-lasting sessions, making it difficult for the child to adhere to the treatment...
December 21, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28088661/reduced-cortical-voluntary-activation-during-bilateral-knee-extension
#14
Luc Girompaire, Baptiste Morel, Thomas Lapole
INTRODUCTION: Reduced neural drive is mainly thought to explain the bilateral deficit phenomenon, i.e. the difference in maximal isometric voluntary contraction (MVC) between unilateral and bilateral contractions. The aim of the present study was to further document if bilateral knee extension is associated with changes in voluntary activation level assessed by both peripheral nerve electrical stimulation and transcranial magnetic stimulation. METHODS: Fourteen subjects performed unilateral and bilateral knee extensions with both superimposed femoral electrical nerve stimulation and transcranial magnetic stimulation in order to assess voluntary activation (VAFNES) and cortical voluntary activation (VATMS), respectively...
January 12, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28088382/functional-electrical-stimulation-for-foot-drop-in-multiple-sclerosis-a-systematic-review-and-meta-analysis-of-the-impact-on-gait-speed
#15
REVIEW
Linda Miller, Angus McFadyen, Anna C Lord, Rebecca Hunter, Lorna Paul, Danny Rafferty, Roy Bowers, Paul Mattison
OBJECTIVE: To review the efficacy of functional electrical stimulation (FES) used for foot drop in people with multiple sclerosis (pwMS) on gait speed in short and long walking performance tests. DATA SOURCES: Five databases (Cochrane Library, CINAHL, Embase, MEDLINE, Pubmed) and reference lists were searched. STUDY SELECTION: Studies of both observational and experimental design where gait speed data in pwMS could be extracted were included...
January 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28087519/sympathetic-modulation-of-electrical-activation-in-normal-and-infarcted-myocardium-implications-for-arrhythmogenesis
#16
Olujimi A Ajijola, Robert L Lux, Anadjeet Khahera, OhJin Kwon, Eric Aliotta, Daniel Ennis, Michael C Fishbein, Jeffrey Laurence Ardell, Kalyanam Shivkumar
: Background The influence of cardiac sympathetic innervation on electrical activation in normal and chronically infarcted ventricular myocardium is not understood. Methods and Results Yorkshire pigs with normal hearts (NL, n=12) or anterior myocardial infarction (MI, n=9) underwent high-resolution mapping of the anteroapical left ventricle, at baseline, and during left and right stellate ganglion stimulation (LSGS & RSGS, respectively). Conduction velocity (CV), activation times (AT), & directionality of propagation were measured...
January 13, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28087265/myocardial-relaxation-is-accelerated-by-fast-stretch-not-reduced-afterload
#17
Charles S Chung, Charles W Hoopes, Kenneth S Campbell
Fast relaxation of cross-bridge generated force in the myocardium facilitates efficient diastolic function. Recently published research studying mechanisms that modulate the relaxation rate has focused on molecular factors. Mechanical factors have received less attention since the 1980s when seminal work established the theory that reducing afterload accelerates the relaxation rate. Clinical trials using afterload reducing drugs, partially based on this theory, have thus far failed to improve outcomes for patients with diastolic dysfunction...
January 10, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28086940/ultrasound-guided-percutaneous-peripheral-nerve-stimulation-for-analgesia-following-total-knee-arthroplasty-a-prospective-feasibility-study
#18
Brian M Ilfeld, Christopher A Gilmore, Stuart A Grant, Michael P Bolognesi, Daniel J Del Gaizo, Amorn Wongsarnpigoon, Joseph W Boggs
BACKGROUND: Peripheral nerve stimulation has been used for decades to treat chronic pain but has not been used for postoperative analgesia due to multiple limitations, beginning with invasive electrode placement. With the development of small-diameter/gauge leads enabling percutaneous insertion, ultrasound guidance for accurate introduction, and stimulators small enough to be adhered to the skin, neurostimulation may now be provided in a similar manner to continuous peripheral nerve blocks...
January 13, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28079995/effects-of-cell-cycle-phases-on-the-induction-of-dental-pulp-stem-cells-toward-dopaminergic-like-cells
#19
Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Premasangery Kathirvaloo, Sabri Musa, Noor Hayaty Abu Kasim
Parkinson's disease (PD) is characterized by tremors and cognitive issues, and is due to the death of dopaminergic (DA-ergic) neurons in brain circuits that are responsible for producing neurotransmitter dopamine (DA). Currently, cell replacement therapies are underway to overcome existing therapeutic approaches such as drug treatments and electrical stimulation. Among the widely available sources, dental pulp stem cells from deciduous teeth (DPSC) have gained popularity due to their neural crest origin and inherent propensity toward neuronal lineage...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28079781/transcutaneous-nerve-stimulation-for-pain-relief-during-office-hysteroscopy-a-randomized-controlled-trial
#20
Juan F Lisón, Juan J Amer-Cuenca, Silvia Piquer-Martí, Vicente Benavent-Caballer, Gemma Biviá-Roig, Alejandro Marín-Buck
OBJECTIVE: To evaluate the pain-relieving effect of transcutaneous electrical nerve stimulation (TENS) during office-based hysteroscopy without sedation. METHODS: We conducted a randomized, double-blind, placebo-controlled trial. Participants were randomly assigned to the active TENS, placebo TENS, or control group. The active TENS intervention consisted of a varying high-frequency (80-100 Hz), 400-microseconds, individually adjusted, high-intensity TENS application with two self-adhesive electrodes placed parallel to the spinal cord at the T10-L1 and S2-S4 levels...
January 9, 2017: Obstetrics and Gynecology
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