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https://www.readbyqxmd.com/read/28449490/transcutaneous-electrical-acupoint-stimulation-teas-ameliorates-chemotherapy-induced-bone-marrow-suppression-in-lung-cancer-patients
#1
Lili Hou, Fen Gu, Guanghui Gao, Caicun Zhou
BACKGROUND: To investigate the effect of percutaneous electrical stimulation on chemotherapy-induced bone marrow suppression in patients with lung cancer. METHODS: From December 2014 to August 2015, one hundred ninety-one non-small cell lung cancer patients with chemotherapy naive were randomly divided into control group, medication group, and transcutaneous electrical acupoint stimulation (TEAS) group. Patients with the control group received routine nursing care, the medication group was treated by oral administration of prophylactic agents, and TEAS group received electrical stimulation of acupoints including Dazhui (DU14), Geshu (BL17), Zusanli (ST36), Sanyinjiao (SP6), and Hegu (LI4)...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28448641/detecting-glaucoma-with-a-portable-brain-computer-interface-for-objective-assessment-of-visual-function-loss
#2
Masaki Nakanishi, Yu-Te Wang, Tzyy-Ping Jung, John K Zao, Yu-Yi Chien, Alberto Diniz-Filho, Fabio B Daga, Yuan-Pin Lin, Yijun Wang, Felipe A Medeiros
Importance: The current assessment of visual field loss in diseases such as glaucoma is affected by the subjectivity of patient responses and the lack of portability of standard perimeters. Objective: To describe the development and initial validation of a portable brain-computer interface (BCI) for objectively assessing visual function loss. Design, Setting, and Participants: This case-control study involved 62 eyes of 33 patients with glaucoma and 30 eyes of 17 healthy participants...
April 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28447988/increased-recovery-time-and-decreased-lps-administration-to-study-the-vagus-nerve-stimulation-mechanisms-in-limited-inflammatory-responses
#3
Erwan Le Maître, Priya Revathikumar, Johanna Estelius, Jon Lampa
Inflammation is a local response to infection and tissue damage mediated by activated macrophages, monocytes, and other immune cells that release cytokines and other mediators of inflammation. For a long time, humoral and cellular mechanisms have been studied for their role in regulating the immune response, but recent advances in the field of immunology and neuroscience have also unraveled specific neural mechanisms with interesting therapeutic potential. The so-called cholinergic anti-inflammatory pathway (CAP) has been described to control innate immune responses and inflammation in a very potent manner...
March 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447862/high-reliability-microcontroller-nerve-stimulator-for-assistance-in-regional-anaesthesia-procedures
#4
Carlos A Ferri, Antonio A F Quevedo
In the last decades, the use of nerve stimulators to aid in regional anaesthesia has been shown to benefit the patient since it allows a better location of the nerve plexus, leading to correct positioning of the needle through which the anaesthetic is applied. However, most of the nerve stimulators available in the market for this purpose do not have the minimum recommended features for a good stimulator, and this can lead to risks to the patient. Thus, this study aims to develop an equipment, using embedded electronics, which meets all the characteristics, for a successful blockade...
April 27, 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/28446944/protective-effects-of-proline-rich-peptide-in-a-rat-model-of-alzheimer-disease-an-electrophysiological-study
#5
Naser Khalaji, John Sarkissian, Vergine Chavushyan, Vaghinak Sarkisian
INTRODUCTION: Alzheimer disease (AD) is the most common form of dementia in the elderly that slowly destroys memory and cognitive functions. The disease has no cure and leads to significant structural and functional brain abnormalities. To facilitate the treatment of this disease, we aimed to investigate proline-rich peptide (PRP-1) action of hypothalamus on hippocampal (HP) neurons and dynamics of their recovery, after intracerebroventricular (ICV) injection of amyloid-β (Aβ). METHODS: Experiments were carried out on 24 adult, male Albino rats (average weight: 230±30 g)...
January 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28446586/muscle-synergies-obtained-from-comprehensive-mapping-of-the-primary-motor-cortex-forelimb-representation-using-high-frequency-long-duration-icms
#6
Sommer L Amundsen Huffmaster, Gustaf M Van Acker, Carl W Luchies, Paul D Cheney
Simplifying neuromuscular control for movement has previously been explored by extracting muscle synergies from voluntary movement electromyography (EMG) patterns. The purpose of this study was to investigate muscle synergies represented in EMG recordings associated with direct electrical stimulation of single sites in primary motor cortex (M1). We applied single electrode high-frequency, long-duration intracortical microstimulation (HFLD-ICMS) to the forelimb region of M1 in two rhesus macaques using parameters previously found to produce forelimb movements to stable spatial endpoints (90-150 Hz, 90-150 μA, 1000 ms stimulus train lengths)...
April 26, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28446584/the-human-primary-somatosensory-cortex-is-differentially-involved-in-vibrotaction-and-nociception
#7
Cédric Lenoir, Gan Huang, Yves Vandermeeren, Samar M Hatem, André Mouraux
The role of the primary somatosensory cortex (S1) in vibrotaction is well established. In contrast, its involvement in nociception remains debated. Here, we test whether S1 is similarly involved in the processing of non-nociceptive and nociceptive somatosensory input in humans by comparing the after-effects of high-definition transcranial direct current stimulation (HD-tDCS) of the primary sensorimotor cortex on the event-related potentials (ERPs) elicited by non-nociceptive and nociceptive somatosensory stimuli delivered to the ipsilateral and contralateral hand...
April 26, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28446579/modulation-of-long-latency-afferent-inhibition-by-the-amplitude-of-sensory-afferent-volley
#8
Claudia V Turco, Jenin El-Sayes, Hunter J Fassett, Robert Chen, Aimee Jennifer Nelson
Long-latency afferent inhibition (LAI) is the inhibition of the transcranial magnetic stimulation (TMS) motor-evoked potentials (MEP) by the sensory afferent volley following electrical stimulation of a peripheral nerve. It is unknown how the activation of sensory afferent fibres relates to the magnitude of LAI. This study investigated the relationship between LAI and the sensory nerve action potentials (SNAP) from the median nerve (MN) and the digital nerves (DN) of the second digit. LAI was obtained by delivering nerve stimulation 200 ms prior to a TMS pulse delivered over the motor cortex...
April 26, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28446427/airway-epithelial-anion-secretion-and-barrier-function-following-exposure-to-fungal-aeroallergens-role-of-oxidative-stress
#9
Nathan A Zaidman, Kelly E O'Grady, Nandadevi Patil, Francesca Milavetz, Peter J Maniak, Hirohito Kita, Scott M O'Grady
Aeroallergens produced by Alternaria alternata can elicit life-threatening exacerbations of asthma in patients sensitized to this fungus. In this study, the effect of Alternaria on ion transport mechanisms underlying mucociliary clearance and airway epithelial barrier function was investigated in human airway epithelial cells. Apical exposure to Alternaria induced an increase in anion secretion that was inhibited by blockers of CFTR and Ca(2+)-activated Cl(-) channels. Stimulation of anion secretion was dependent on Ca(2+) uptake from the apical solution...
April 26, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28446181/a-neuromuscular-electrical-stimulation-nmes-and-robot-hybrid-system-for-multi-joint-coordinated-upper-limb-rehabilitation-after-stroke
#10
Wei Rong, Waiming Li, Mankit Pang, Junyan Hu, Xijun Wei, Bibo Yang, Honwah Wai, Xiaoxiang Zheng, Xiaoling Hu
BACKGROUND: It is a challenge to reduce the muscular discoordination in the paretic upper limb after stroke in the traditional rehabilitation programs. METHOD: In this study, a neuromuscular electrical stimulation (NMES) and robot hybrid system was developed for multi-joint coordinated upper limb physical training. The system could assist the elbow, wrist and fingers to conduct arm reaching out, hand opening/grasping and arm withdrawing by tracking an indicative moving cursor on the screen of a computer, with the support from the joint motors and electrical stimulations on target muscles, under the voluntary intention control by electromyography (EMG)...
April 26, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28446119/neurobionics-and-the-brain-computer-interface-current-applications-and-future-horizons
#11
Jeffrey V Rosenfeld, Yan Tat Wong
The brain-computer interface (BCI) is an exciting advance in neuroscience and engineering. In a motor BCI, electrical recordings from the motor cortex of paralysed humans are decoded by a computer and used to drive robotic arms or to restore movement in a paralysed hand by stimulating the muscles in the forearm. Simultaneously integrating a BCI with the sensory cortex will further enhance dexterity and fine control. BCIs are also being developed to: provide ambulation for paraplegic patients through controlling robotic exoskeletons; restore vision in people with acquired blindness; detect and control epileptic seizures; and improve control of movement disorders and memory enhancement...
May 1, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28446015/realistic-electric-field-mapping-of-anisotropic-muscle-during-electrical-stimulation-using-a-combination-of-water-diffusion-tensor-and-electrical-conductivity
#12
Bup Kyung Choi, Tong In Oh, Saurav Zk Sajib, Jin Woong Kim, Hyung Joong Kim, Oh In Kwon, Eung Je Woo
PURPOSE: To realistically map the electric fields of biological tissues using a diffusion tensor magnetic resonance electrical impedance tomography (DT-MREIT) method to estimate tissue response during electrical stimulation. METHODS: Imaging experiments were performed using chunks of bovine muscle. Two silver wire electrodes were positioned inside the muscle tissue for electrical stimulation. Electric pulses were applied with a 100-V amplitude and 100-μs width using a voltage stimulator...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28445862/treatments-of-traumatic-neuropathic-pain-a-systematic-review
#13
Chenglun Yao, Xijie Zhou, Bin Zhao, Chao Sun, Keshav Poonit, Hede Yan
Traumatic neuropathic pain caused by traumatic neuroma has long been bothering both doctors and patients, the mechanisms of traumatic neuropathic pain are widely discussed by researchers and the treatment is challenging. Clinical treatment of painful neuroma is unclear. Numerous treatment modalities have been introduced by experts in this field. However, there is still no single standard recognized treatment.Different forms of treatments have been tested in animals and humans, but pharmacotherapies (antidepressants, antiepileptics) remain the basis of traumatic neuropathic pain management...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445741/memory-scrutinized-through-electrical-brain-stimulation-a-review-of-80-years-of-experiential-phenomena
#14
REVIEW
Jonathan Curot, Thomas Busigny, Luc Valton, Marie Denuelle, Jean-Pierre Vignal, Louis Maillard, Patrick Chauvel, Jérémie Pariente, Agnès Trebuchon, Fabrice Bartolomei, Emmanuel J Barbeau
Electrical Brain Stimulations (EBS) sometimes induce reminiscences, but it is largely unknown what type of memories they can trigger. We reviewed 80 years of literature on reminiscences induced by EBS and added our own database. We classified them according to modern conceptions of memory. We observed a surprisingly large variety of reminiscences covering all aspects of declarative memory. However, most were poorly detailed and only a few were episodic. This result does not support theories of a highly stable and detailed memory, as initially postulated, and still widely believed as true by the general public...
April 23, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28445695/neural-correlates-of-evoked-phantom-limb-sensations
#15
J Andoh, M Diers, C Milde, C Köppe, D Kleinböhl, H Flor
Previous work showed the existence of changes in the topographic organization within the somatosensory cortex (SI) in amputees with phantom limb pain, however, the link between nonpainful phantom sensations such as cramping or tingling or the percept of the limb and cortical changes is less clear. We used functional magnetic resonance imaging (fMRI) in a highly selective group of limb amputees who experienced inducible and reproducible nonpainful phantom sensations. A standardized procedure was used to locate body sites eliciting phantom sensations in each amputee...
April 23, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28445595/ventricular-fibrillation-cardiac-arrest-produces-a-chronic-striatal-hyperdopaminergic-state-that-is-worsened-by-methylphenidate-treatment
#16
Gerald J Nora, Rashed Harun, David F Fine, Daniel Hutchison, Adam C Grobart, Jason P Stezoski, Miranda Munoz, Patrick M Kochanek, Rehana K Leak, Tomas Drabek, Amy K Wagner
Cardiac arrest survival rates have improved with modern resuscitation techniques, but many survivors experience impairments associated with hypoxic-ischemic brain injury. Currently, little is understood about chronic changes in striatal dopamine (DA) systems after hypoxic-ischemic brain injury. Given the common empiric clinical use of DA enhancing agents in neurorehabilitation, investigation evaluating dopaminergic alterations after cardiac arrest (CA) is necessary to optimize rehabilitation approaches. We hypothesized that striatal DA neurotransmission would be altered chronically after ventricular fibrillation cardiac arrest (VF-CA)...
April 26, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28445482/questionable-science-and-reproducibility-in-electrical-brain-stimulation-research
#17
Martin E Héroux, Colleen K Loo, Janet L Taylor, Simon C Gandevia
Electrical brain stimulation (EBS) is a trendy new technique used to change brain function and treat neurological, psychiatric and psychological disorders. We were curious whether the published literature, which is dominated by positive results, reflects the experience of researchers using EBS. Specifically, we wanted to know whether researchers are able to reproduce published EBS effects and whether they engage in, but fail to report, questionable research practices. We invited 976 researchers to complete an online survey...
2017: PloS One
https://www.readbyqxmd.com/read/28445249/study-on-the-mechanisms-of-seizure-like-events-suppression-effect-by-electrical-stimulation-using-a-microelectrode-array
#18
Sora Ahn, Sumin Jo, Sang Beom Jun, Hyang Woon Lee, Seungjun Lee
In this paper, we studied the mechanisms underlying the suppression of seizure-like events (SLEs) by electrical stimulation. We conducted an in-vitro experiment using entorhinal cortex combined hippocampal slices and two convulsant drugs, bicuculline and 4-aminopyridine, to induce spontaneous SLEs. We used a microelectrode array to observe network dynamics over the entire hippocampal area simultaneously, including regions far from the stimulation site. We stimulated the entorhinal cortex region, which has been determined to be a focus of SLEs by Granger causality analysis of multichannel time series data, by an external electrode...
April 25, 2017: Neuroreport
https://www.readbyqxmd.com/read/28444940/h-reflex-and-m-wave-recordings-effect-of-pressure-application-to-the-stimulation-electrode-on-the-assessment-of-evoked-potentials-and-subject-s-discomfort
#19
Thomas Cattagni, Angèle N Merlet, Christophe Cornu, Marc Jubeau
This study aimed to compare the effect of different types of pressure applied to the stimulation electrode on assessing the efficiency of Ia-α-motoneuron transmission of the soleus muscle and the associated discomfort using electrical nerve stimulation. Twelve healthy young adults participated in three experimental sessions (one for each knee angle). The amplitudes of the maximal Hoffmann reflex (Hmax ) and motor potential (Mmax ) were recorded from the soleus muscle at 0°, 30° and 90° knee angles (0° full extension) through three pressure applications to the stimulation electrode: no pressure, pressure with manual application and pressure using adhesive tape...
April 26, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28444176/-j-waves-induced-after-short-coupling-intervals-a-manifestations-of-latent-depolarization-abnormality
#20
Yoshifusa Aizawa, Masafumi Nakayama, Masahito Sato, Masaaki Okabe, Yoshiyasu Aizawa, Seiji Takatsuki, Keiichi Fukuda
Aims: To confirm the presence of tachycardia-induced slur or notch in the terminal portion of the QRS complexes in a general patient population. Methods and results: A tachycardia-induced J wave was defined as a slur or notch in the terminal portion of the QRS complexes newly induced at short RR intervals during atrial premature contractions (APCs) or atrial electrical stimulation in the electrophysiological study (EPS). Twenty-three out of 2000 patients with general diseases were involved...
April 24, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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