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TVR signaling

Jennifer Alfaro, Felipe Pérez de Arce, Sebastián Belmar, Glenda Fuentealba, Patricio Avila, Gonzalo Ureta, Camila Flores, Claudia Acuña, Luz Delgado, Diana Gaete, Brahmam Pujala, Anup Barde, Anjan K Nayak, T V R Upendra, Dhananjay Patel, Shailender Chauhan, Vijay K Sharma, Stacy Kanno, Ramona G Almirez, David T Hung, Sarvajit Chakravarty, Roopa Rai, Sebastián Bernales, Kevin P Quinn, Son M Pham, Emma McCullagh
Although new targeted therapies, such as ibrutinib and idelalisib, have made a large impact on non-Hodgkin's lymphoma (NHL) patients, the disease is often fatal because patients are initially resistant to these targeted therapies, or because they eventually develop resistance. New drugs and treatments are necessary for these patients. One attractive approach is to inhibit multiple parallel pathways that drive the growth of these hematologic tumors, possibly prolonging the duration of the response and reducing resistance...
May 2017: Journal of Pharmacology and Experimental Therapeutics
Damiano Lo Presti, Roberta Licia Scala, Grazia Maria Tiralongo, Ilaria Pisani, Giulia Gagliardi, Gian Paolo Novelli, Barbara Vasapollo, Herbert Valensise
INTRODUCTION: From early pregnancy, maternal hemodynamic profile begins to change. The absence of these changes leads to increased risk of complication during the gestation. OBJECTIVES: Aim of this study is to understand in early pregnancy the behaviour of total vascular resistances (TVR) as a sign of maternal cardiovascular adaptation to pregnancy. METHOD: A cross section study was conducted. We followed 160 healthy women with singleton pregnancy during the first trimester of gestation...
April 2013: Pregnancy Hypertension
Damiano Lo Presti, Roberta Licia Scala, Grazia Maria Tiralongo, Ilaria Pisani, Giulia Gagliardi, Gian Paolo Novelli, Barbara Vasapollo, Angela Andreoli, Herbert Valensise
INTRODUCTION: In pregnancy there is an increase in maternal cardiac output (CO) and a reduction in total vascular resistance (TVR). Abnormalities of this adaptive mechanisms lead to numerous disorders of pregnancy. Moreover the mother's body water composition undergoes important modifications in total body water (TBW), extracellular and intracellular body water (EBW, IBW). OBJECTIVES: Aim of the study is to identify a group of patients at high risk of developing hypertensive complications of pregnancy in frist trimester...
April 2013: Pregnancy Hypertension
G M Tiralongo, D Lo Presti, I Pisani, G Gagliardi, R L Scala, G P Novelli, B Vasapollo, A Andreoli, H Valensise
INTRODUCTION: Maternal cardiovascular system adapts to pregnancy, thanks to complex physiological mechanisms that involve cardiac output, total vascular resistance and water body distribution. Abnormalities of these adaptive mechanisms are connected with hypertensive disorders. OBJECTIVE: To identify patients at a high risk of developing hypertensive complications of pregnancy during the first trimester of pregnancy, through the use of non-invasive methods such as USCOM (Ultrasonic Cardiac Output Monitor) and Bioimpedance...
April 2015: Pregnancy Hypertension
Nina L Suresh, Inga Wang, C J Heckman, W Zev Rymer
The objective of our study was to assess the role of persistent inward currents, or PICs, on the excitability of motoneurons innervating spastic muscle in hemi-spastic stroke individuals. This was accomplished by examining the effects of tonic vibration applied to the tendon of the biceps brachii muscle. The elicited TVR (tonic vibration reflex) provides a useful way to assess the degree of excitability of spinal neurons in spastic syndromes, and it has additional features that may signify the presence of PICs in spastic motoneurons...
2011: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Jai Madhok, Shrivats Iyer, Nitish V Thakor, Anil Maybhate
This paper describes an innovative, easy-to-interpret, clinically translatable tool for analysis of Somatosensory Evoked Potentials (SSEPs). Unlike traditional analysis, which involves peak-to-peak amplitude and latency calculation, this method, phase space analysis, analyzes the overall morphology of the SSEP, and includes greater information. The SSEP is plotted in phase space (x-dot vs. x), which leads to an approximately spiral curve. The area swept out by this curve is termed the Phase Space Area (PSA)...
2010: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Christian R Berger, Weian Chen, Shengli Zhou, Jie Huang
Underwater acoustic orthogonal frequency division multiplexing (OFDM) enables simple frequency domain equalization, but its performance is often limited by intercarrier interference (ICI) that is induced by channel variation, in addition to the ambient noise. As the signal itself, the variance of the ICI is frequency dependent as (i) the transmitter often has a nonideal transmit voltage response (TVR) and (ii) underwater acoustic propagation introduces frequency dependent attenuation. In this paper, a simple method to account for the frequency dependent spectrum of the ICI plus noise is proposed...
April 2010: Journal of the Acoustical Society of America
Wing-Cheong Wong, Siu-Yeung Cho, Chai Quek
In general, a fuzzy neural network (FNN) is characterized by its learning algorithm and its linguistic knowledge representation. However, it does not necessarily interact with its environment when the training data is assumed to be an accurate description of the environment under consideration. In interactive problems, it would be more appropriate for an agent to learn from its own experience through interactions with the environment, i.e., reinforcement learning. In this paper, three clustering algorithms are developed based on the reinforcement learning paradigm...
November 2009: IEEE Transactions on Neural Networks
H Tatsura, H Nagao, A Tamada, S Sasaki, K Kohri, K Mori
Pheromone receptors are expressed in the accessory olfactory system, which is vital for non-specific chemical communication and for sexual behavior. Under the hypothesis that some of the pheromone molecules released from female reproductive organs might regulate sperm chemotaxis or chemokinesis, we examined whether the V1R type pheromone receptor mRNAs are expressed in developing germ cells. By a reverse transcription-PCR method, we obtained nine kinds of cDNA fragments belonging to the receptor family. In situ hybridization analysis in testicular sections using probes of testicular pheromone receptors (TVRs) revealed that TVR mRNAs were expressed by spermatids...
January 19, 2001: FEBS Letters
A Watanabe, J Pokorny, V C Smith
Chromatic discrimination thresholds were measured under conditions which yielded fine and degraded discrimination steps. Discrimination was assessed by identification of the location of one of four homogeneous equiluminant stimuli arranged in a square or with pseudoisochromatic (PIC) figures using the stimulus design of Regan, Reffin and Mollon (Vis Res 1994; 34: 1279-1299). Stimuli were presented on CRT monitors and specified in units of cone trolands. They were viewed within a surround metameric to the equal energy spectrum...
November 1998: Vision Research
T Sugimoto, T Ota, K Nakamura
To determine appropriate surgical management of secondary tricuspid regurgitation (TR), we attempted to quantify TR volume by using two-dimensional color Doppler echocardiography (2-DD) and continuous wave Doppler echocardiography (CW). Thirty patients with TR associated with acquired valvular disease were selected for the study. 1. The new quantitative method: TR was observed from two right-angled cross-sections in 2-DD (one; the parasternal long-axis view of the right ventricular inflow tract, and another; the apical four-chamber view or short-axis view at the level of the aortic valve)...
December 1988: Journal of Cardiology
M Kalloniatis, R S Harwerth
The effects of chromatic adaptation on the opponent interactions of cone mechanisms were investigated by using increment-threshold spectral-sensitivity (ITSS) functions and threshold-versus-radiance (TVR) curves in rhesus monkey subjects. The TVR curves showed shape- and field-sensitivity invariance for both 580- and 500-nm adapting backgrounds and indicated that three cone mechanisms were mediating detection over moderate adapting-field intensity levels. Differential adaptation between the long-wavelength-sensitive (L) and the middle-wavelength-sensitive (M) opponent (L - M) and nonopponent (L + M) channels and the short-wavelength-sensitive (S) channel caused changes in the shape of the ITSS function as the adapting-field intensity was increased without changes in the level of cone interaction...
November 1991: Journal of the Optical Society of America. A, Optics and Image Science
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