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https://www.readbyqxmd.com/read/28415833/molecular-characterization-and-biodiversity-of-a-putative-chlorotoxin-from-the-iranian-yellow-scorpion-odontobuthus-doriae
#1
Maryam Naderi Soorki, Amir Jalali, Hamid Galehdari
BAckground: Chloride channels have already been over-expressed in the different types of cancer. Chlorotoxins, as the blocking agent of these channels, have been indicated to be an effective drug against tumors. In this study, we characterized a putative chlorotoxin from a cDNA library of the venom glands obtained from the Iranian scorpion Odontobuthus doriae. Methods: A cDNA library was constructed from venom gland transcriptome of six scorpions. The cDNA encoding Odontobuthus doriae chlorotoxin was isolated from the library, and its putative peptide was characterized by some bioinformatics software such as protein blast, SignalP4...
April 18, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28382194/wound-healing-activity-of-extracts-and-formulations-of-aloe-vera-henna-adiantum-capillus-veneris-and-myrrh-on-mouse-dermal-fibroblast-cells
#2
Samira Negahdari, Hamid Galehdari, Mahnaz Kesmati, Anahita Rezaie, Gholamreza Shariati
BACKGROUND: Among the most important factors in wound healing pathways are transforming growth factor beta1 and vascular endothelial growth factor. Fibroblasts are the main cell in all phases wound closure. In this study, the extracts of plant materials such as Adiantum capillus-veneris, Commiphora molmol, Aloe vera, and henna and one mixture of them were used to treatment of normal mouse skin fibroblasts. METHODS: Cytotoxic effects of each extract and their mixture were assessed on mouse skin fibroblasts cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28190459/mutations-in-inpp5k-cause-a-form-of-congenital-muscular-dystrophy-overlapping-marinesco-sj%C3%A3-gren-syndrome-and-dystroglycanopathy
#3
Daniel P S Osborn, Heather L Pond, Neda Mazaheri, Jeremy Dejardin, Christopher J Munn, Khaloob Mushref, Edmund S Cauley, Isabella Moroni, Maria Barbara Pasanisi, Elizabeth A Sellars, R Sean Hill, Jennifer N Partlow, Rebecca K Willaert, Jaipreet Bharj, Reza Azizi Malamiri, Hamid Galehdari, Gholamreza Shariati, Reza Maroofian, Marina Mora, Laura E Swan, Thomas Voit, Francesco J Conti, Yalda Jamshidi, M Chiara Manzini
Congenital muscular dystrophies display a wide phenotypic and genetic heterogeneity. The combination of clinical, biochemical, and molecular genetic findings must be considered to obtain the precise diagnosis and provide appropriate genetic counselling. Here we report five individuals from four families presenting with variable clinical features including muscular dystrophy with a reduction in dystroglycan glycosylation, short stature, intellectual disability, and cataracts, overlapping both the dystroglycanopathies and Marinesco-Sjögren syndrome...
March 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28112527/identification-of-a-novel-hadhb-gene-mutation-in-an-iranian-patient-with-mitochondrial-trifunctional-protein-deficiency
#4
Mahdiyeh Shahrokhi, Mohammad Shafiei, Hamid Galehdari, Gholamreza Shariati
INTRODUCTION: Mitochondrial trifunctional protein (MTP) is a hetero-octamer composed of eight parts (subunits): four α-subunits containing LCEH (long-chain 2,3-enoyl-CoA  hydratase) and LCHAD (long-chain 3-hydroxyacyl CoA dehydrogenase) activity, and four β-subunits that possess LCKT (long-chain  3-ketoacyl-CoA thiolase) activity which catalyzes three out of four steps in β-oxidation spiral of long-chain fatty acid. Its deficiency is an autosomal recessive disorder that causes a clinical spectrum of diseases...
January 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27794585/a-novel-defensin-like-peptide-associated-with-two-other-new-cationic-antimicrobial-peptides-in-transcriptome-of-the-iranian-scorpion-venom
#5
Masoumeh Baradaran, Amir Jalali, Maryam Naderi Soorki, Hamid Galehdari
INTRODUCTION: Scorpion venom is a source of bioactive peptides, and some antimicrobial peptides (AMPs) have been found in the venom gland of scorpions. Therefore, the discovery of new anti-infective agents is an essential need to overcome the problem of antibiotic resistance of clinical isolates. Here, we describe three new cationic AMPs, including meuVAP-6, meuAP-18-1, and meuPep34 from the venom gland of the Iranian scorpion, Mesobuthus eupeus. METHODS: The cDNA sequences encoding all the three peptides were obtained from the cDNA library of scorpion venom gland and were deposited in the GenBank database...
May 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27716154/effect-of-the-herbal-mixture-composed-of-aloe-vera-henna-adiantum-capillus-veneris-and-myrrha-on-wound-healing-in-streptozotocin-induced-diabetic-rats
#6
Hamid Galehdari, Samira Negahdari, Mahnaz Kesmati, Anahita Rezaie, Gholamreza Shariati
BACKGROUND: Wound healing is often impaired in diabetic animals and humans. Matrix metalloproteases act as pro-inflammatory agents in physiological wound healing pathways by stimulating cytokines including the interleukins, IL6, IL1A and IL1B, and the tumor necrosis factor and transforming growth factor beta1. Botanicals are traditionally used to assist healing of different types of wounds, because they produce fewer side effects. Our specific aim here was to develop a plant-based recipe supporting effective wound healing in diabetic animals...
October 6, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27437095/novel-mutation-in-the-atp-binding-cassette-transporter-a3-abca3-encoding-gene-causes-respiratory-distress-syndrome-in-a-term-newborn-in-southwest-iran
#7
Farideh Rezaei, Mohammad Shafiei, Gholamreza Shariati, Ali Dehdashtian, Maryam Mohebbi, Hamid Galehdari
INTRODUCTION: ABCA3 glycoprotein belongs to the ATP-binding cassette (ABC) superfamily of transporters, which utilize the energy derived from hydrolysis of ATP for the translocation of a wide variety of substrates across the plasma membrane. Mutations in the ABCA3 gene are knowingly causative for fatal surfactant deficiency, particularly respiratory distress syndrome (RDS) in term babies. CASE PRESENTATION: In this study, Sanger sequencing of the whole ABCA3 gene (NCBI NM_001089) was performed in a neonatal boy with severe RDS...
April 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/27426055/first-venom-gland-transcriptomic-analysis-of-iranian-yellow-scorpion-odonthubuthus-doriae-with-some-new-findings
#8
Maryam NaderiSoorki, Hamid Galehdari, Masomeh Baradaran, Amir Jalali
Scorpion venom contains mixture of biologic molecules including selective toxins with medical capability. Odonthubuthus doriae (O. doriae) belonged to Buthidae family of scorpions and gained more interest among Iranian dangerous scorpion since 2005. We constructed the first cDNA library to explore the transcriptomic composition of this Iranian scorpiontelson. Then by used of bioinformatic software each expression sequence taq (EST) from the library analyzed and its quiddity was clear. Analysis showed that toxins (42%) had more venom transcript than other component such as antimicrobial peptides, venom peptides and cell proteins...
September 15, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/26948378/the-first-report-of-a-290-bp-deletion-in-%C3%AE-globin-gene-in-the-south-of-iran
#9
Mohammad Hamid, Ladan Dawoody Nejad, Gholamreza Shariati, Hamid Galehdari, Alihossein Saberi, Marziye Mohammadi-Anaei
BACKGROUND: β-thalassemia is one of the most widespread disease in the world, including Iran. In this study, we reported, for the first time, a 290-bp β-globin gene deletion in the south of Iran. METHODS: Four individuals from three unrelated families with Arabic ethnic background were studied in Khuzestan Province. Red blood cell indices and hemoglobin analysis were carried out according to the standard methods. Genomic DNA was obtained from peripheral blood cells by salting out procedures...
2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/26878087/evaluation-of-%C3%AE-globin-gene-mutations-among-different-ethnic-groups-in-khuzestan-province-southwest-iran
#10
Abbas Khosravi, Mohammadali Jalali-Far, Najmaldin Saki, Hossein Hosseini, Hamid Galehdari, Omid Kiani-Ghalesardi, Mostafa Paridar, Azita Azarkeivan, Kabir Magaji-Hamid
α-Thalassemia (α-thal) is one of the most common inherited hemoglobin (Hb) disorders in the world. In addition to large deletions, over 50 different α-thal point mutations were detected around the world, thus, patients showed different phenotypes with regard to genotype. This study evaluated the genetic frequency of α-thal in Khuzestan Province, Southwest Iran, to help implement premarital and prenatal screening programs. The study was conducted on couples proposing to get married and parents who were referred to the genetic center of Shafa Hospital, Ahvaz, Iran, for prenatal diagnosis (PND) in 2012...
2016: Hemoglobin
https://www.readbyqxmd.com/read/26597055/association-study-of-rs1333040-and-rs1004638-polymorphisms-in-the-9p21-locus-with-coronary-artery-disease-in-southwest-of-iran
#11
Khadijeh Golabgir Khademi, Ali Mohammad Foroughmand, Hamid Galehdari, Saied Yazdankhah, Mahdi Pourmahdi Borujeni, Zahra Shahbazi, Parvaneh Dinarvand
BACKGROUND: Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. METHODS: Blood samples were collected from 200 CAD patients and 110 healthy individuals with no CAD. The association of two SNPs with CAD was evaluated by PCR and restriction fragment length polymorphism...
2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/26535028/time-depended-bcl-2-inhibition-might-be-useful-for-a-targeted-drug-therapy
#12
REVIEW
Abdolhassan Talaiezadeh, Fateme Jalali, Hamid Galehdari, Ali Khodadadi
BACKGROUND: Over expression of Bcl-2 is frequently observed in several types of cancers and it is one of the prognostic markers in breast cancer. The importance of the Bcl-2 protein as ideal therapeutic target is the dual role of inhibiting apoptosis and autophagy-mediated cell death. Thus, the bcl-2 targeting may be a strategy of choice to improve treatment efficacy and overcome drug resistance to cancer chemotherapy. For this reason, we designed the siRNA mediated silencing of the Bcl-2 gene in the MCF-7 breast cancer cell line...
2015: Cancer Cell International
https://www.readbyqxmd.com/read/26443252/analysis-of-hla-dqb1-0602-in-multiple-sclerosis-patients-in-khuzestan-province-iran
#13
Rezvan Zabihi, Hamid Galehdari, Mohammad Shafiee, Sayed Reza Kazeminejad, Sayed Mohammad Reza Alavi
BACKGROUND: Multiple sclerosis (MS) is a chronic, demyelinating, autoimmune and also complex disease of the central nervous system the etiology of which is not completely defined; but both genetic and environmental factors are regarded as main factors in its susceptibility. HLA-DQB1*0602 is considered as one of the most important genetic factors in MS predisposition but contradictory results have been reported in different populations world-wide. Since there are no data with respect to the correlation of HLA-DQB1*0602 and multiple sclerosis in Khuzestan province, and because of ethnic diversity in Khuzestan province, the aim was to examine the association of this allele with multiple sclerosis in Khuzestan...
October 2015: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/26246877/assessment-of-correlation-between-androgen-receptor-cag-repeat-length-and-infertility-in-infertile-men-living-in-khuzestan-iran
#14
Saeid Reza Khatami, Hamid Galehdari, Abdorrahman Rasekh, Hayat Mombeini, Elham Konar
BACKGROUND: The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat that encodes a polyglutamine tract in its N-terminal transactivation domain (N- TAD). We aimed to find a correlation between the length of this polymorphic tract and azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran. MATERIALS AND METHODS: In this case-control study during two years till 2010, we searched for microdeletions in the Y chromosome in 84 infertile male patients with normal karyotype who lived in Khuzestan Province, Southwest of Iran...
July 2015: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/26221130/association-of-androgen-receptor-ggn-repeat-length-polymorphism-and-male-infertility-in-khuzestan-iran
#15
Mohamad Moghadam, Saied Reza Khatami, Hamid Galehdari
BACKGROUND: Androgens play critical role in secondary sexual and male gonads differentiations such as spermatogenesis, via androgen receptor. The human androgen receptor (AR) encoding gene contains two regions with three nucleotide polymorphic repeats (CAG and GGN) in the first exon. Unlike the CAG repeats, the GGN has been less studied because of technical difficulties, so the functional role of these polymorphic repeats is still unclear. OBJECTIVE: The goal of this study was to investigate any relationship between GGN repeat length in the first exon of AR gene and idiopathic male infertility in southwest of Iran...
May 2015: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/26135932/a-significant-upregulation-of-mir5-886-p-in-high-grade-and-invasive-bladder-tumors
#16
Atefeh Khoshnevisan, Mahmoud Parvin, Nasim Ghorbanmehr, Nasim Hatefi, Hamid Galehdari, Seyed Amir Mohsen Ziaee, Seyed Javad Mowla
PURPOSE: To investigate the expression alteration of miR5-886-p in bladder tumors and evaluating its expression level as a potential biomarker in this type of cancer. MATERIALS AND METHODS: Formalin-fixed paraffin-embedded (FFPE) samples of bladder tumors belonging to 70 patients whom had been referred to the Shahid Labbafi-Nejad medical center were obtained from the archival collection of pathology department. After RNA extraction and cDNA synthesis, expression levels of miR5-886-p were quantified by a real-time reverse transcription polymerase chain reaction (RT-PCR) approach...
May 2015: Urology Journal
https://www.readbyqxmd.com/read/25870838/association-study-between-coronary-artery-disease-and-rs1333049-and-rs10757274-polymorphisms-at-9p21-locus-in-south-west-iran
#17
Ali Mohammad Foroughmand, Emad Nikkhah, Hamid Galehdari, Mohammad Hossin Jadbabaee
OBJECTIVE: Coronary artery disease (CAD) is a multi-factorial and heterogenic disease with atherosclerosis plaques formation in internal wall of coronary artery. Plaque formation results to limitation of the blood reaching to myocardium leading to appearance of some problems, such as ischemia, sudden thrombosis veins and myocardial infarction (MI). Several environmental and genetic factors are involved in prevalence and incident of CAD as follows: hypertension, high low density lipoprotein-cholesterol (LDL-C), age, diabetes mellitus, family history of early-onset heart disease and smoking...
2015: Cell Journal
https://www.readbyqxmd.com/read/25834710/cloning-and-expression-of-poly-3-hydroxybutyrate-operon-into-escherichia-coli
#18
Maryam Jari, Saeid Reza Khatami, Hamid Galehdari, Mohammad Shafiei
BACKGROUND: Poly 3-Hydroxybutyrate (PHB), a class of Poly Hydroxyalkanoates (PHAs), is a group of bacterial storage polymers, produced by various microorganisms in response to nutrient limitation. PHAs are biodegradable polymers which could be a good substitute for current petrochemical plastics. PHB has been synthesized during three enzymatic steps including three genes. OBJECTIVES: Our aim was PHB production from recombinant bacteria. MATERIALS AND METHODS: Ralstonia eutropha was cultured and its genomic DNA was extracted...
February 2015: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/25767710/molecular-prenatal-diagnosis-of-megalencephalic-leukoencephalopathy-with-subcortical-cysts-in-a-child-from-southwest-of-iran
#19
Gholamreza Shariati, Mohammad Hamid, Alihossein Saberi, Behnaz Andashti, Hamid Galehdari
Megalencephalic leukoencephalopathy (MLC) is a rare neurological disorder with an autosomal recessive pattern. Clinical diagnosis was based on macrocephaly, recurrent seizure, and magnetic resonance imaging (MRI). Here we report first finding of a novel homozygous single base deletion in the MLC1 gene in an affected Iranian child causing a premature stop codon (p.L150fs.160X).
February 2015: Clinical Case Reports
https://www.readbyqxmd.com/read/25625052/verapamil-and-rifampin-effect-on-p-glycoprotein-expression-in-hepatocellular-carcinoma
#20
Amir Jalali, Sepideh Ghasemian, Hossein Najafzadeh, Hamid Galehdari, Masoud Reza Seifi, Fateme Zangene, Shaiesteh Dehdardargahi
BACKGROUND: High expression of p-glycoprotein (P-gp) has been associated with a poor prognosis in patients with hepatocellular carcinoma (HCC). It is likely that P-gp overexpression is responsible for multidrug resistance in HCC. OBJECTIVES: The aim of this study was to elucidate the effect of potent carcinogen nitrosamine with and without verapamil and rifampin drugs on P-gp expression at the mRNA level in HCC. MATERIALS AND METHODS: Four groups of rats (n = 5) were selected with different treatments and one group as control...
November 2014: Jundishapur Journal of Natural Pharmaceutical Products
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