Nathan Denlinger, No-Joon Song, Xiaoli Zhang, Hyeongseon Jeon, Chelsea Peterson, Yi Wang, Kelsi Reynolds, Robert Bolz, Jessica Miao, Chunhua Song, Dayong Wu, Wing Keung Chan, Evandro D Bezerra, Narendranath Epperla, Timothy J Voorhees, Jonathan E Brammer, Adam S Kittai, David A Bond, Yazeed Sawalha, Audrey M Sigmund, John C Reneau, Mark P Rubinstein, Walter Hanel, Beth Christian, Robert A Baiocchi, Kami J Maddocks, Lapo Alinari, Sumithira Vasu, Marcos de Lima, Dongjun Chung, Samantha M Jaglowski, Zihai Li, Xiaopei Huang, Yiping Yang
Chimeric antigen receptor T cell therapy (CAR-T) has revolutionized treatment for relapsed/refractory (r/r) B-cell non-Hodgkin's lymphoma (NHL). Robust biomarkers and a complete understanding of CAR-T cell function in the post-infusion phase remain limited. Here we used a 37-color spectral flow cytometry panel to perform high dimensional single cell analysis of post-infusion samples in 26 patients treated with CD28 co-stimulatory domain containing commercial CAR-T (CD28-CAR-T) for NHL and focused on computationally gated CD8+ CAR-T cells...
March 23, 2024: Blood Advances