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https://www.readbyqxmd.com/read/29334490/differential-impact-of-local-and-regional-aortic-stiffness-on-left-ventricular-remodeling-a-cardiovascular-magnetic-resonance-study
#1
Thiago Quinaglia, Mourad Z Bensalah, Emilie Bollache, Nadjia Kachenoura, Gilles Soulat, Pierre Boutouyrie, Stéphane Laurent, Elie Mousseaux
BACKGROUND: Left ventricular (LV) remodeling and aortic stiffness have independent predictive value for all causes and cardiovascular mortality. Because elastic properties of the arterial wall vary along the aortic pathway, we hypothesized that local and regional aortic stiffness could differently impact on LV remodeling. METHODS AND RESULTS: Regional aortic stiffness was determined from carotid-femoral pulse wave velocity (cfPWV) measured by aplanation tonometry...
January 13, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29330739/patterns-and-outcomes-of-prescribing-venous-thromboembolism-prophylaxis-in-hospitalized-older-adults-a-retrospective-cohort-study
#2
Mark Goldin, Jessica Cohen, Alex Makhnevich, Colm Mulvany, Meredith Akerman, Liron Sinvani
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in the United States. Hospitalized, medically ill older adults have increased risk; despite guidelines, data suggest suboptimal pharmacologic prophylaxis rates. Factors influencing provider prescribing non-compliance are unclear. We aimed to describe VTE prophylaxis practices and identify risk factors for, and outcomes of, prescribing non-compliance. A retrospective study was conducted of hospitalized adults aged ≥ 75 years, admitted to the medicine service of a large academic tertiary center from May 1, 2014 to June 30, 2015...
January 12, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29330152/risk-of-infection-in-type-1-and-type-2-diabetes-compared-with-the-general-population-a-matched-cohort-study
#3
Iain M Carey, Julia A Critchley, Stephen DeWilde, Tess Harris, Fay J Hosking, Derek G Cook
OBJECTIVE: We describe in detail the burden of infections in adults with diabetes within a large national population cohort. We also compare infection rates between patients with type 1 and type 2 diabetes mellitus (T1DM and T2DM). RESEARCH DESIGN AND METHODS: A retrospective cohort study compared 102,493 English primary care patients aged 40-89 years with a diabetes diagnosis by 2008 (n = 5,863 T1DM and n = 96,630 T2DM) with 203,518 age-sex-practice-matched control subjects without diabetes...
January 12, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29329975/risk-of-suicide-and-non-fatal-self-harm-after-bariatric-surgery-results-from-two-matched-cohort-studies
#4
Martin Neovius, Gustaf Bruze, Peter Jacobson, Kajsa Sjöholm, Kari Johansson, Fredrik Granath, Johan Sundström, Ingmar Näslund, Claude Marcus, Johan Ottosson, Markku Peltonen, Lena M S Carlsson
BACKGROUND: Bariatric surgery reduces mortality, but might have adverse effects on mental health. We assessed the risk of suicide and self-harm after bariatric surgery compared with non-surgical obesity treatment. METHODS: Suicide and non-fatal self-harm events retrieved from nationwide Swedish registers were examined in two cohorts. The non-randomised, prospective Swedish Obese Subjects (SOS) study compared bariatric surgery (n=2010; 1369 vertical-banded gastroplasty, 376 gastric banding, and 265 gastric bypass) with usual care (n=2037; recruitment 1987-2001)...
January 9, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29327184/efficacy-of-forced-air-warming-to-prevent-perioperative-hypothermia-in-morbidly-obese-versus-non-obese-patients
#5
Raphael Okoué, Daniela Calabrese, Pascal Nzé, Simon Msika, Hawa Keita
BACKGROUND: Hypothermia is associated with an increased postoperative morbidity and mortality. Forced-air warming systems are the most effective methods for its prevention. When using a mattress, a reduction in the area of diffusion of warm air by crushing due to excess weight cannot be ruled out. METHODS: We designed a prospective study to compare the efficacy of a forced-air warming mattress (Bair Hugger® 585) to prevent hypothermia (core temperature (CT°) < 36 °C) in morbidly obese (group MO, body mass index (BMI) ≥ 40 kg/m2) and non-obese patients (group NO, BMI < 30 kg/m2)...
January 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29322708/high-prevalence-of-obstructive-sleep-apnea-among-people-with-type-2-diabetes-mellitus-in-a-tertiary-care-center
#6
Vijay Viswanathan, Indira Priyadarshini Ramalingam, Nagarajan Ramakrishnan
Purpose: Untreated obstructive sleep apnea (OSA) is a risk factor for hypertension and cardiac events, and is associated with increased mortality. Recent studies indicate that majority of people with type 2 diabetes also has OSA. The aim of this study was to assess the prevalence and severity of OSA and risk factors contributing to it among people with chronic and severe type 2 diabetes. Methods: A total of 203 people with type 2 diabetes (mean age: 54±8 years, 145 males, 58 females, HbA1c ≥7% [53mmol/mol]) attending a diabetes specialty hospital were included in the study; all were subjected to comprehensive diabetic evaluation and Apnea Hypopnea Index (AHI) was used to evaluate OSA...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29320770/long-term-survivor-characteristics-in-hemodialysis-patients-with-type-2-diabetes
#7
Susanne Triebswetter, Lena J Gutjahr-Lengsfeld, Kay-Renke Schmidt, Christiane Drechsler, Christoph Wanner, Vera Krane
BACKGROUND: Data concerning long-term mortality predictors among large, purely diabetic hemodialysis collectives are scarce. METHODS: We used data from a multicenter, prospective, randomized trial among 1,255 hemodialysis patients with type 2 diabetes mellitus (T2DM) and its observational follow-up study. The association of 10 baseline candidate variables with mortality was assessed by Cox proportional hazards regression. RESULTS: Overall, 103 participants survived the median follow-up of 11...
January 10, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29320517/explaining-the-decline-in-coronary-heart-disease-mortality-rates-in-the-slovak-republic-between-1993-2008
#8
Marek Psota, Piotr Bandosz, Eva Gonçalvesová, Mária Avdičová, Mária Bucek Pšenková, Martin Studenčan, Jarmila Pekarčíková, Simon Capewell, Martin O'Flaherty
OBJECTIVE: Between the years 1993 and 2008, mortality rates from coronary heart disease (CHD) in the Slovak Republic have decreased by almost one quarter. However, this was a smaller decline than in neighbouring countries. The aim of this modelling study was therefore to quantify the contributions of risk factor changes and the use of evidence-based medical therapies to the CHD mortality decline between 1993 and 2008. METHODS: We identified, obtained and scrutinised the data required for the model...
2018: PloS One
https://www.readbyqxmd.com/read/29319245/cardiometabolic-risk-factors-in-acute-coronary-syndrome-with-special-reference-to-non-hdl-cholesterol
#9
Debjani S Goswami, Tanuja P Manohar
Introduction: Cardiovascular diseases are becoming the major cause of morbidity and mortality in most of the developing countries including India. Cardiometabolic risk factors play a vital role in causation of coronary artery disease. Present study was carried out to investigate the role of various risk factors in the occurrence of coronary artery disease (CAD) in population from Central India. Settings and Design: This was a hospital-based age and sex matched case-control study, carried out at Lata Mangeshkar Hospital, Nagpur...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29319016/analysis-of-post-operative-complication-in-single-port-laparoscopic-cholecystectomy-a-retrospective-analysis-in-817-cases-from-a-surgeon
#10
Yongmin Lee, Younghoon Roh, Minchan Kim, Younghoon Kim, Kwanwoo Kim, Sunghwa Kang, Eunjeong Jang
BACKGROUND: Single-port laparoscopic cholecystectomy (SPLC) is a new advanced technique in laparoscopic surgery which has many benefits according to previous reports. The purpose of this study was to present personal experiences with SPLC in> 800 cases performed by a surgeon to evaluate the safety and feasibility of this procedure. MATERIALS AND METHODS: A retrospective review of 817 cases of SPLC was conducted. All patients had received elective SPLC by a surgeon in our centre during March 2009-August 2015...
January 10, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29318343/short-term-progression-of-cardiometabolic-risk-factors-in-relation-to-age-at-type-2-diabetes-diagnosis-a-longitudinal-observational-study-of-100-606-individuals-from-the-swedish-national-diabetes-register
#11
Andri O Steinarsson, Araz Rawshani, Soffia Gudbjörnsdottir, Stefan Franzén, Ann-Marie Svensson, Naveed Sattar
AIMS/HYPOTHESIS: The reasons underlying a greater association of premature mortality with early-onset type 2 diabetes relative to late-onset disease are unclear. We evaluated the clinical characteristics at type 2 diabetes diagnosis and the broad trajectories in cardiometabolic risk factors over the initial years following diagnosis in relation to age at diagnosis. METHODS: Our cohort consisted of 100,606 individuals with newly diagnosed type 2 diabetes enrolled in the Swedish National Diabetes Register from 2002 to 2012...
January 9, 2018: Diabetologia
https://www.readbyqxmd.com/read/29313572/cardio-metabolic-risk-profile-in-women-with-previous-history-of-pre-eclampsia
#12
Jalees Fatma, Ritu Karoli, Zeba Siddiqui, H P Gupta, Ashok Chandra, Mahima Pandey
Introduction: Preeclampsia is one of the leading causes of maternal and neonatal morbidity and mortality. However there is growing evidence that there are differences during the post partum period between subjects with prior preeclampsia and prior uncomplicated pregnancy and women with a history of preeclampsia are more likely to develop cardiovascular disease later in life. The aim of our study was to assess the cardio- metabolic risk profile in women with previous history of pre-eclampsia and to their counterparts who had normal pregnancy...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29312971/impact-of-sarcopenic-overweight-on-the-outcomes-after-living-donor-liver-transplantation
#13
Ahmed Hammad, Toshimi Kaido, Yuhei Hamaguchi, Shinya Okumura, Atsushi Kobayashi, Hisaya Shirai, Naoko Kamo, Shintaro Yagi, Shinji Uemoto
Background: The effect of body composition disturbances has been recently in focus. Sarcopenic obesity, a co-occurrence of low muscle mass and high body fat was reportedly predictive of high mortality in patients with cirrhosis. However, the impact of the interacting sarcopenia and overweight on the outcomes after liver transplantation is still unclear. Methods: We evaluated 200 patients undergoing adult-to-adult living donor liver transplantation at our institution between January 2008 and November 2013 classified according to BMI and psoas muscle index (PMI) on admission to transplant into 4 subgroups; sarcopenic overweight (SO), sarcopenic non-overweight (SN), non-sarcopenic overweight and non-sarcopenic non-overweight (NN)...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29312705/anemia-as-a-clinical-marker-of-stable-chronic-obstructive-pulmonary-disease-in-the-korean-obstructive-lung-disease-cohort
#14
Yeon-Mok Oh, Joo Hun Park, Eun-Kyung Kim, Sung Chul Hwang, Hyun Ji Kim, Dae Ryong Kang, Kwang Ha Yoo, Ji-Hyun Lee, Tae-Hyung Kim, Seong Yong Lim, Chin Kook Rhee, Hyoung Kyu Yoon, Sang Yeub Lee, Sang-Do Lee
Background: Anemia is a major co-morbidity in chronic obstructive pulmonary disease (COPD). However, the mechanism of development for anemia and the impact of anemia on the prognosis of COPD remain poorly understood. Therefore, this study attempted to evaluate the prognostic role of anemia on the clinical course of COPD and investigate the factors linked with the serum hemoglobin level in COPD. Methods: We analyzed 407 COPD patients enrolled in the Korean obstructive lung disease (KOLD) cohort at 16 hospitals in Korea recruited over 9 years...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29310998/coronary-artery-calcifications-and-diastolic-dysfunction-versus-visceral-fat-area-in-type-1-diabetes-viscera-study
#15
Christophe E M De Block, Bharati Shivalkar, Wouter Goovaerts, Tim Brits, Ken Carpentier, An Verrijken, Viviane Van Hoof, Paul M Parizel, Chris Vrints, Luc F Van Gaal
AIMS: Type 1 diabetic patients (T1DM) experience a higher cardiovascular disease and mortality risk than controls. We investigated whether visceral adipose tissue (VAT) contributes to coronary artery calcifications (CAC) and cardiac dysfunction in T1DM. METHODS: A cross-sectional study of 118 T1DM patients without a history of cardiovascular disease (men/women: 68/50, age 46±12years, HbA1c 7.6±0.9%, BMI 25.8±4.1kg/m2) was conducted. CAC and VAT were measured using a CT scan...
November 28, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29310892/sarcopenia-is-not-associated-with-morbidity-mortality-or-recurrence-after-esophagectomy-for-cancer
#16
Steve R Siegal, James P Dolan, Elizabeth N Dewey, Alexander R Guimaraes, Brandon H Tieu, Paul H Schipper, John G Hunter
BACKGROUND: Sarcopenia is associated with increased morbidity and mortality in hepatic, pancreatic and colorectal cancer. We examined the effect of sarcopenia on morbidity, mortality, and recurrence after resection for esophageal cancer. METHODS: Retrospective review of consecutive esophagectomies from 2010 to 2015. Computed tomography studies were analyzed for sarcopenia. Morbidity was analyzed using Fischer's test and survival data with Kaplan Meier curves. RESULTS: The sarcopenic group (n = 127) had lower BMI, later stage disease, and higher incidence of neoadjuvant radiation than those without sarcopenia (n = 46)...
January 4, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29305071/effectiveness-of-guideline-consistent-heart-failure-drug-prescriptions-at-hospital-discharge-on-1-year-mortality-results-from-the-epical2-cohort-study
#17
Amandine Busson, Nathalie Thilly, Hervé Laborde-Castérot, François Alla, Ziyad Messikh, Isabelle Clerc-Urmes, Alexandre Mebazaa, Marc Soudant, Nelly Agrinier
BACKGROUND: We aimed to assess the effectiveness of recommended drug prescriptions at hospital discharge on 1-year mortality in patients with heart failure (HF) and reduced ejection fraction (HFREF). MATERIALS AND METHODS: We used data from the EPICAL2 cohort study. HF patients ≥18years old with left ventricular ejection fraction (LVEF) <40% and alive at discharge were included and followed up for mortality. Socio-demographic, clinical and therapeutic data were collected at admission...
January 2, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29304751/what-is-the-best-adjustment-of-appendicular-lean-mass-for-predicting-mortality-or-disability-among-japanese-community-dwellers
#18
Rei Otsuka, Yasumoto Matsui, Chikako Tange, Yukiko Nishita, Makiko Tomida, Fujiko Ando, Hiroshi Shimokata, Hidenori Arai
BACKGROUND: Age-related declines in skeletal muscle mass and strength, representing "sarcopenia," are a growing concern in aging societies. However, the prevalence of low muscle mass based on the height2-adjustment has been shown to be extremely low, and a more appropriate definition of low muscle mass is needed, particularly for Asian women. The aim of this study was to explore the most appropriate adjustment of appendicular lean mass (ALM) for predicting mortality or disability risk using ALM or any of 5 adjustments of ALM among community-dwelling Japanese...
January 5, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29304064/hyperleptinemia-positively-associated-with-central-arterial-stiffness-in-hemodialysis-patients
#19
Chiu-Huang Kuo, Yu-Li Lin, Chung-Jen Lee, Chih-Hsien Wang, Yu-Hsien Lai, Hung-Hsiang Liou, Bang-Gee Hsu
OBJECTIVE: Leptin plays a role in stimulating vascular inflammation, vascular smooth muscle hypertrophy, and augmenting blood pressure, which contributes to the pathogenesis of atherosclerosis and leads to arterial stiffness. This vascular damage, measured by carotid-femoral pulse wave velocity (cfPWV), is recognized as an independent predictor of cardiovascular mortality in hemodialysis (HD) patients. The aim of this study was to evaluate the relationship between serum leptin and arterial stiffness in HD patients...
2018: PloS One
https://www.readbyqxmd.com/read/29298801/bmi-and-mortality-in-patients-with-new-onset-type-2-diabetes-a-comparison-with-age-and-sex-matched-control-subjects-from-the-general-population
#20
Jon Edqvist, Araz Rawshani, Martin Adiels, Lena Björck, Marcus Lind, Ann-Marie Svensson, Sofia Gudbjörnsdottir, Naveed Sattar, Annika Rosengren
OBJECTIVE: Type 2 diabetes is strongly associated with obesity, but the mortality risk related to elevated body weight in people with type 2 diabetes compared with people without diabetes has not been established. RESEARCH DESIGN AND METHODS: We prospectively assessed short- and long-term mortality in people with type 2 diabetes with a recorded diabetes duration ≤5 years identified from the Swedish National Diabetes Registry between 1998 and 2012 and five age- and sex-matched control subjects per study participant from the general population...
January 3, 2018: Diabetes Care
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