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Lipoprotein ratios

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https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#1
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28436724/circulating-proprotein-convertase-subtilisin-kexin-type-9-all-cause-mortality-and-cardiovascular-mortality-the-ludwigshafen-risk-and-cardiovascular-health-study
#2
Günther Silbernagel, Hubert Scharnagl, Marcus E Kleber, Tatjana Stojakovic, Winfried März
Background It is unclear whether proprotein convertase subtilisin-kexin type 9 (PCSK9) concentrations may be useful for cardiovascular risk stratification. Design The LUdwigshafen RIsk and Cardiovascular health (LURIC) study is a prospective observational registry of patients who were referred for coronary angiography. Methods Circulating PCSK9 was measured in 2139 participants of the LURIC study. There was a follow-up for all-cause and cardiovascular mortality with a median (interquartile range) duration of 10...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28436274/depletion-of-hdl3-high-density-lipoprotein-and-altered-functionality-of-hdl2-in-blood-from-sickle-cell-patients
#3
Eric Soupene, Sandra K Larkin, Frans A Kuypers
In sickle cell disease (SCD), alterations of cholesterol metabolism is in part related to abnormal levels and activity of plasma proteins such as lecithin cholesterol acyltransferase (LCAT), and apolipoprotein A-I (ApoA-I). In addition, the size distribution of ApoA-I high density lipoproteins (HDL) differs from normal blood. The ratio of the amount of HDL2 particle relative to the smaller higher density pre-β HDL (HDL3) particle was shifted toward HDL2. This lipoprotein imbalance is exacerbated during acute vaso-occlusive episodes (VOE) as the relative levels of HDL3 decrease...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28436169/plasma-concentrations-of-lipids-during-pregnancy-and-the-risk-of-gestational-diabetes-mellitus-a-longitudinal-study
#4
Wei Bao, Sharon Dar, Yeyi Zhu, Jing Wu, Shristi Rawal, Shanshan Li, Natalie L Weir, Michael Y Tsai, Cuilin Zhang
BACKGROUND: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. We aimed to characterize the longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid levels with risk of GDM. METHODS: This is a nested case-control study including 107 GDM cases and 214 matched non-GDM controls from participants in the NICHD Fetal Growth Studies-Singleton Cohort...
April 24, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28431918/gender-dependent-effects-of-fasting-blood-glucose-levels-and-disease-duration-on-biochemical-markers-in-type-2-diabetics-a-pilot-study
#5
Abhijit A Ghadge, Arundhati G Diwan, Abhay M Harsulkar, Aniket A Kuvalekar
AIM: The impact of fasting blood glucose levels (FBG) and disease duration on type 2 diabetes in Indian population is still unclear. The present study examines gender-dependent effects of FBG and disease duration on lipid profile, adipocytokines and related biochemical parameters in diabetic individuals. METHODS: Type 2 diabetic individuals (n=100) were classified depending on FBG: patients with normal FBG (Glucose<126mg/dl) and patients with high FBG (Glucose≥126mg/dl); and disease duration: ≥0-≤3yr, >3-≤7yr, >7yr...
April 7, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28431391/serum-levels-of-lead-mercury-and-cadmium-in-relation-to-coronary-artery-disease-in-the-elderly-a-cross-sectional-study
#6
Sedigheh Asgary, Ahmad Movahedian, Mahtab Keshvari, Mahsa Taleghani, Amirhossein Sahebkar, Nizal Sarrafzadegan
BACKGROUND: There is a continuing attempt to identify novel factors that can predict the risk of cardiovascular disease beyond the established coronary risk factors. It has been suggested that serum levels of lead, mercury and cadmium are associated with the risk of coronary artery disease (CAD). In the present study, we aimed to evaluate serum concentrations of lead (s-Pb), mercury (s-Hg) and cadmium (s-Cd) in patients with CAD in comparison with those of healthy individuals. The correlation between serum levels of these heavy metals and lipid profile parameters was also investigated...
March 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/28430815/soy-and-fish-as-features-of-the-japanese-diet-and-cardiovascular-disease-risks
#7
Yukio Yamori, Miki Sagara, Yoshimi Arai, Hitomi Kobayashi, Kazumi Kishimoto, Ikuko Matsuno, Hideki Mori, Mari Mori
In the World Health Organization (WHO)-coordinated Cardiovascular Disease and Alimentary Comparison Study, isoflavones (I; biomarker for dietary soy) and taurine (T; biomarker for dietary fish) in 24-hour-urine (24U) were inversely related to coronary heart disease (CHD) mortality. High levels of these biomarkers are found in Japanese people, whose CHD mortality is lowest among developed countries. We analyzed the association of these biomarkers with cardiovascular disease risk in the Japanese to know their health effects within one ethnic population...
2017: PloS One
https://www.readbyqxmd.com/read/28430614/features-and-risk-factors-of-carotid-atherosclerosis-in-a-population-with-high-stroke-incidence-in-china
#8
Yanqiu Zhang, Lingling Bai, Min Shi, Hongyan Lu, Yanan Wu, Jun Tu, Jingxian Ni, Jinghua Wang, Li Cao, Ping Lei, Xianjia Ning
Epidemiological studies have reported associations between traditional cardiovascular risk factors and carotid intima-media thickness (CIMT) or carotid plaque. However, definite risk factors at different phases of carotid atherosclerosis remain controversial. We aimed to explore risk factors and characteristics of carotid atherosclerosis at different stages in a low-income population with a high incidence of stroke in China. Between April 2014 and January 2015, we recruited 3789 stroke-free and cardiovascular disease-free residents aged ≥ 45 years...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429921/relationship-between-dietary-patterns-and-brachial-ankle-pulse-wave-velocity-among-middle-aged-adults-in-japan
#9
Shota Moyama, Kazuhiro Minami, Mihiro Yano, Masumi Okumura, Susumu Hayashi, Hiroshi Takayama, Akira Yorimoto
BACKGROUND AND OBJECTIVES: Arterial stiffness is a leading cause of cardiovascular disease (CVD), and it is considered to be affected by dietary intake. However, few studies have examined the relationship between major dietary patterns and brachial-ankle pulse wave velocity (baPWV) among Japanese middle-aged subjects. We studied whether major dietary patterns were associated with baPWV in this population. METHODS AND STUDY DESIGN: Between 2009 and 2012, 70 Japanese middle-aged subjects (39 men and 31 women) with no history of stroke, coronary heart disease, or cancer were studied...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28429599/lipoprotein-associated-phospholipase-a2-and-risk-of-carotid-atherosclerosis-and-cardiovascular-events-in-community-based-older-adults-in-china
#10
Chunxiu Wang, Xianghua Fang, Yang Hua, Yutong Liu, Zhongying Zhang, Xiang Gu, Xiaoguang Wu, Zhe Tang, Shaochen Guan, Hongjun Liu, Beibei Liu, Xiuhai Guo, Xunming Ji
We explored the associations between lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid atherosclerosis with all phenotypes and cardiovascular disease (CVD) events in Chinese older adults. A total of 1257 adults aged ≥55 years who were free of CVD were enrolled in this cohort study. Lipoprotein-associated phospholipase A2 level was evaluated in 3 categories: Lp-PLA2 < 175, 175≤ Lp-PLA2 < 223, and Lp-PLA2 ≥ 223 ng/mL. The highest level of Lp-PLA2 was independently associated with common carotid artery intima-media thickening (≥1...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28428941/cardiovascular-risk-may-be-increased-in-women-with-unexplained-infertility
#11
Fatma Ferda Verit, Fadile Yildiz Zeyrek, Ali Galip Zebitay, Hurkan Akyol
OBJECTIVE: Growing evidence suggests that increased cardiovascular disease (CVD) risk is associated with female infertility caused by conditions such as polycystic ovarian disease, obesity, thyroid dysfunction, and endometriosis. The aim of this study was to evaluate whether any relationship exists between CVD and unexplained infertility. METHODS: Sixty-five women with unexplained infertility and 65 fertile controls were enrolled in the study. CVD risk markers such as low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), triglycerides (TG), insulin resistance (defined by the homeostasis model assessment ratio), and high-sensitivity C-reactive protein (hs-CRP) were assessed...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28427375/relation-between-metabolic-syndrome-and-body-compositions-among-chinese-adolescents-and-adults-from-a-large-scale-population-survey
#12
Tao Xu, Junting Liu, Junxiu Liu, Guangjin Zhu, Shaomei Han
BACKGROUND: Few nationally representative surveys regarding body composition and metabolic syndrome (MetS) have been done in a large-scale representative Chinese population to explore the prediction of body composition indicators for MetS. The objective of this study was to examine the relation of body composition and MetS and to determine the optimal cut-off values of body composition indicators that predict MetS in a large representative Chinese sample based on multiple provinces and ethnicities, covering a broad age range from 10 to 80 years old...
April 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28426345/economic-evaluation-of-ezetimibe-treatment-in-combination-with-statin-therapy-in-the-united-states
#13
Glenn M Davies, Ami Vyas, Carl A Baxter
AIMS: This study assessed the cost-effectiveness of ezetimibe with statin therapy versus statin monotherapy from a United States (US) payer perspective, assuming the impending patent expiration of ezetimibe. METHODS: A Markov-like economic model consisting of 28 distinct health states was used. Model population data were obtained from US linked claims and electronic medical records, with inclusion criteria based on diagnostic guidelines. Inputs came from recent clinical trials, meta-analyses, and cost-effectiveness analyses...
April 20, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28422176/the-characteristics-of-newly-diagnosed-adult-early-onset-diabetes-a-population-based-cross-sectional-study
#14
Xiantong Zou, Xianghai Zhou, Linong Ji, Wenying Yang, Juming Lu, Jianping Weng, Weiping Jia, Zhongyan Shan, Jie Liu, Haoming Tian, Qiuhe Ji, Dalong Zhu, Jiapu Ge, Lixiang Lin, Li Chen, Xiaohui Guo, Zhigang Zhao, Qiang Li, Zhiguang Zhou
To investigate the characteristics of newly diagnosed early-onset diabetes in the Chinese population, 2801 newly diagnosed diabetes participants without known diabetes or pre-diabetes in a national cross-sectional survey were analysed. Participants were divided into quartiles (22-43, 44-52, 53-61 and >61 years) according to age of diabetes onset and the first group were defined as early-onset diabetes group. Early-onset diabetes group had lower systolic blood pressure (SBP), total cholesterol, low density lipoprotein cholesterol, 2-hour post prandial blood glucose and urine albumin creatinine ratio...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421814/elevated-monocyte-to-high-density-lipoprotein-cholesterol-ratio-and-endothelial-dysfunction-in-beh%C3%A3-et-disease
#15
Nusret Acikgoz, Ertuğrul Kurtoğlu, Julide Yagmur, Yelda Kapicioglu, Mehmet Cansel, Necip Ermis
Behçet disease (BD) is a multisystemic disorder characterized by endothelial dysfunction and inflammation. Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged indicator of inflammation and oxidative stress. Sixty patients with BD and 50 control individuals were included to investigate the relationship between MHR and endothelial dysfunction. Endothelial function was assessed by flow- and nitroglycerin-mediated dilatation technique (FMD and NMD, respectively). Serum high-sensitivity C-reactive protein (hsCRP) levels were measured in all study participants...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28420579/clustering-of-cardio-metabolic-risk-factors-in-iranian-adult-population-a-growing-problem-in-the-north-of-iran
#16
K Hajian-Tilaki, B Heidari, A R Firouzjahi
INTRODUCTION: The clustering of components of metabolic syndrome (MetS) is a major concern in a transition population because of dramatic changing toward modern life styles. The objective of this study was to determine the prevalence of clustering of various combinations of MetS and its association with obesity. METHODS AND SUBJECTS: In a population- based cross-sectional study, a representative samples of 1000 adults were recruited in Babol, the north of Iran. The demographic data, blood pressure, body mass index and waist circumference (WC) were measured with standard method...
March 6, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28419274/extreme-high-high-density-lipoprotein-cholesterol-is-paradoxically-associated-with-high-mortality-in-men-and-women-two-prospective-cohort-studies
#17
Christian M Madsen, Anette Varbo, Børge G Nordestgaard
Aims: High-density lipoprotein (HDL) cholesterol concentrations are inversely associated with cardiovascular disease and mortality across a range of concentrations, but genetic evidence suggest that extreme high concentrations may paradoxically lead to more cardiovascular disease. We tested the hypothesis that extreme high concentrations of HDL cholesterol are associated with high all-cause mortality in men and women. Methods and results: A total of 52 268 men and 64 240 women were included from the two prospective population-based studies, the Copenhagen City Heart Study and the Copenhagen General Population Study...
April 12, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28418031/serum-concentration-of-hdl-particles-predicts-mortality-in-acute-heart-failure-patients
#18
Ines Potočnjak, Vesna Degoricija, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, Gunther Marsche, Saša Frank
Clinical studies have shown that assessing circulating concentrations of high-density lipoprotein (HDL) particles by nuclear magnetic resonance (NMR) spectroscopy is superior to HDL-cholesterol in predicting cardiovascular risk. We tested the hypothesis that circulating concentrations of HDL particles predict 3-month mortality of patients with acute heart failure (AHF). Out of 152 included patients, 52% were female, additionally the mean patient age was 75.2 ± 10.3 years, and three-month mortality was 27%...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416782/assessment-of-atherosclerotic-risk-among-patients-with-epilepsy-on-valproic-acid-lamotrigine-and-carbamazepine-treatment
#19
Nudrat A Zuberi, Mukhtiar Baig, Shazia Bano, Zehra Batool, Saeeda Haider, Tahira Perveen
OBJECTIVE: To compare the long-term effects of carbamazepine (CBZ), valproic acid (VPA), and lamotrigine (LTG) as monotherapy on the markers of vascular risk. METHODS: The present cross-sectional study was carried out at the Department of Neurology, Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pakistan, from 2012 to 2013. We selected 120 adult patients with epilepsy and 40 control subjects. The patients with epilepsy were divided into 3 groups according to the use of antiepileptic drugs (AEDs) (CBZ, n = 40; VPA, n = 40; and LTG, n = 40)...
April 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28416524/range-of-risk-factor-levels-control-mortality-and-cardiovascular-outcomes-in-type-1-diabetes-mellitus
#20
Aidin Rawshani, Araz Rawshani, Stefan Franzén, Björn Eliasson, Ann-Marie Svensson, Mervete Miftaraj, Darren K McGuire, Naveed Sattar, Annika Rosengren, Soffia Gudbjörnsdottir
BACKGROUND: Individuals with type 1 diabetes mellitus (T1DM) have a high risk of cardiovascular complications, but it is unknown to what extent fulfilling all cardiovascular treatment goals is associated with residual risk of mortality and cardiovascular outcomes in those with T1DM compared with the general population. METHODS: We included all patients ≥18 years of age with T1DM who were registered in the Swedish National Diabetes Register from January 1, 1998, through December 31, 2014, a total of 33 333 patients, each matched for age and sex with 5 controls without diabetes mellitus randomly selected from the population...
April 18, 2017: Circulation
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