Pellegrino Crafa, Marilisa Franceschi, Kryssia Isabel Rodriguez-Castro, Lorella Franzoni, Michele Russo, Giovanni Brandimarte, Antonio Tursi, Massimo Rugge, Francesco Di Mario
Hydrochloric acid is crucial in gastric physiology. In 1978 cimetidine, the first H2 antagonist of histamine receptors on the gastric parietal cell was introduced into therapy, inducing acid. Lasting the years, several studies focused on the potential relationship between inducing hypo-achlorhydria and risk of developing gastric cancer. In 1988 omeprazole, the first proton pump inhibitor, entered therapy. In 1996, Kuipers underlined the danger of progression of chronic atrophic gastritis in subjects taking PPIs...
June 14, 2023: Acta Bio-medica: Atenei Parmensis