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https://www.readbyqxmd.com/read/28340144/preventive-chemotherapy-in-one-year-reduces-by-over-80-the-number-of-individuals-with-soil-transmitted-helminthiases-causing-morbidity-results-from-meta-analysis
#1
Chiara Marocco, Mathieu Bangert, Serene A Joseph, Christopher Fitzpatrick, Antonio Montresor
The morbidity due to Ascaris lumbricoides and Trichuris trichiura is caused by infections of moderate and heavy intensity while hookworm infections of all intensities are recognized to cause morbidity.This study aims to evaluate the effect of repeated rounds of preventive chemotherapy on the proportion of soil-transmitted helminth (STH) infections causing morbidity. We identified studies from 17 countries, reporting changes in the proportion of STH infection causing morbidity between baseline and follow-up...
March 18, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28324468/ascariasis-and-hyperosmolar-hyperglycemic-state-a-surprising-ultrasound-finding-in-the-emergency-department
#2
Giles N Cattermole, Jean-Paul Nzabandora
BACKGROUND: We report the ultrasound finding of ascariasis in a patient with hyperosmolar hyperglycemic state (HHS). Although ascariasis is common in low-resource settings, there has been no previous report associating ascariasis with HHS. CASE PRESENTATION: A 26-year-old Rwandan man was admitted to the emergency department in coma, with a glycemia of 600 mg/dl. He was resuscitated with fluids, intubated and ventilated, and treated with insulin and antibiotics...
December 2017: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28302147/soil-transmitted-helminths-and-plasmodium-falciparum-malaria-among-individuals-living-in-different-agroecosystems-in-two-rural-communities-in-the-mount-cameroon-area-a-cross-sectional-study
#3
Irene Ule Ngole Sumbele, Gladys Belanka Nkemnji, Helen Kuokuo Kimbi
BACKGROUND: Soil-transmitted helminths (STHs) and Plasmodium falciparum infections remain public health problems in Cameroon. A cross-sectional study was carried out in the Mount Cameroon area to determine the prevalence and intensity of STHs and P. falciparum infections in individuals living in different agroecosystems; to assess the influence of these infections on haematological parameters; and to identify the risk factors associated with STH infections. METHODS: STH and malaria parasites were detected using the Kato-Katz method and Giemsa staining of blood films, respectively...
March 16, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28295446/a-recombinant-cystatin-from-ascaris-lumbricoides-attenuates-inflammation-of-dss-induced-colitis
#4
Sandra Coronado, Luis Barrios, Josefina Zakzuk, Ronald Regino, Velky Ahumada, Luis Franco, Yanet Ocampo, Luis Caraballo
Helminthiasis may ameliorate inflammatory diseases, such as inflammatory bowel disease and asthma. Information about immunomodulators from Ascaris lumbricoides is scarce, but could be important considering the co-evolutionary relationships between helminths and humans. We evaluated the immunomodulatory effects of a recombinant cystatin from A. lumbricoides on an acute model of Dextran Sodium Sulphate (DSS)-induced colitis in mice. From an A. lumbricoides cDNA library we obtained a recombinant cystatin (rAl-CPI)...
March 10, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28290266/improved-diagnosis-of-trichuris-trichiura-by-using-a-bead-beating-procedure-on-ethanol-preserved-stool-samples-prior-to-dna-isolation-and-the-performance-of-multiplex-real-time-pcr-for-intestinal-parasites
#5
Maria M M Kaisar, Eric A T Brienen, Yenny Djuardi, Erliyani Sartono, Maria Yazdanbakhsh, Jaco J Verweij, Taniawati Supali, Lisette VAN Lieshout
For the majority of intestinal parasites, real-time PCR-based diagnosis outperforms microscopy. However, the data for Trichuris trichiura have been less convincing and most comparative studies have been performed in populations with low prevalence. This study aims to improve detection of T. trichuria DNA in human stool by evaluating four sample preparation methods. Faecal samples (n = 60) were collected at Flores island, Indonesia and examined by microscopy. Aliquots were taken and a bead-beating procedure was used both on directly frozen stool and on material preserved with 96% ethanol...
March 14, 2017: Parasitology
https://www.readbyqxmd.com/read/28285891/effect-of-fenbendazole-in-water-on-pigs-infected-with-ascaris-suum-in-finishing-pigs-under-field-conditions
#6
Brian Lassen, Claudio Oliviero, Toomas Orro, Elias Jukola, Tapio Laurila, Minna Haimi-Hakala, Mari Heinonen
The husbandry of pigs for meat production is a constantly developing industry. Most studies on the effects of Ascaris suum infection in pigs and its prevention with anthelmintics are over a decade old. We examined the effect of 2.5mg fenbendazole per kg bodyweight administered in drinking water for two consecutive days on A. suum infection 1 and 6 weeks after pigs arrived to fattening units. We hypothesised that the treatment would reduce the presence of A. suum-infections, improve the average daily weight gain of pigs, reduce the percentage of liver rejections in pens by 50% and increase the lean meat percentage at slaughter by 1%...
March 6, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28284979/effect-of-polymorphisms-on-tgfb1-on-allergic-asthma-and-helminth-infection-in-an-african-admixed-population
#7
Ryan Dos Santos Costa, Camila Alexandrina Figueiredo, Maurıcio Lima Barreto, Neuza Maria Alcantara-Neves, Laura Cunha Rodrigues, Alvaro A Cruz, Candelaria Vergara, Nicholas Rafaels, Cassandra Foster, Joseph Potee, Monica Campbell, Rasika A Mathias, Kathleen C Barnes
BACKGROUND: Allergic asthma is a complex disorder that results from a combination of genetic and environmental factors. Studies suggest that helminth infections can activate a regulatory network characterized by the production of regulatory cytokines, such as interleukin 10 and transforming growth factor β1 (TGF-β1) and subsequently protect against immune-mediated diseases, such as asthma. On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation...
March 8, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28279454/comparison-and-validation-of-two-mathematical-models-for-the-impact-of-mass-drug-administration-on-ascaris-lumbricoides-and-hookworm-infection
#8
Luc E Coffeng, James E Truscott, Sam H Farrell, Hugo C Turner, Rajiv Sarkar, Gagandeep Kang, Sake J de Vlas, Roy M Anderson
The predictions of two mathematical models of the transmission dynamics of Ascaris lumbricoides and hookworm infection and the impact of mass drug administration (MDA) are compared, using data from India. One model has an age structured partial differential equation (PDE) deterministic framework for the distribution of parasite numbers per host and sexual mating. The second model is an individual-based stochastic model. Baseline data acquired prior to treatment are used to estimate key transmission parameters, and forward projections are made, given the known MDA population coverage...
March 2017: Epidemics
https://www.readbyqxmd.com/read/28273080/geospatial-distribution-of-intestinal-parasitic-infections-in-rio-de-janeiro-brazil-and-its-association-with-social-determinants
#9
Clarissa Perez Faria, Graziela Maria Zanini, Gisele Silva Dias, Sidnei da Silva, Marcelo Bessa de Freitas, Ricardo Almendra, Paula Santana, Maria do Céu Sousa
BACKGROUND: Intestinal parasitic infections remain among the most common infectious diseases worldwide. This study aimed to estimate their prevalence and provide a detailed analysis of geographical distribution of intestinal parasites in the metropolitan region of Rio de Janeiro, considering demographic, socio-economic, and epidemiological contextual factors. METHODS/PRINCIPAL FINDINGS: The cross-section survey was conducted among individuals attending the Evandro Chagas National Institute of Infectious Diseases (FIOCRUZ, RJ) during the period from April 2012 to February 2015...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28264707/parasitic-contamination-of-raw-vegetables-and-fruits-collected-from-selected-local-markets-in-arba-minch-town-southern-ethiopia
#10
Fitsum Bekele, Tamirat Tefera, Gelila Biresaw, Tsegaye Yohannes
BACKGROUND: One way that people get infected with intestinal parasites is through the consumption of contaminated vegetables and fruits. This study aimed at determining the prevalence and predictors of parasitic contamination of fruits and vegetables collected from four local markets in Arba Minch town, Southern Ethiopia. METHODS: A cross-sectional study was conducted from 1 to 21 September 2014 to determine the level of parasitic contamination of fruits and vegetables sold in Arba Minch town...
March 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28238285/urogenital-schistosomiasis-and-soil-transmitted-helminthiasis-sth-in-cameroon-an-epidemiological-update-at-barombi-mbo-and-barombi-kotto-crater-lakes-assessing-prospects-for-intensified-control-interventions
#11
Suzy J Campbell, J Russell Stothard, Faye O'Halloran, Deborah Sankey, Timothy Durant, Dieudonné Eloundou Ombede, Gwladys Djomkam Chuinteu, Bonnie L Webster, Lucas Cunningham, E James LaCourse, Louis-Albert Tchuem-Tchuenté
BACKGROUND: The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously. To collect contemporary epidemiological information, a cross-sectional survey was undertaken inclusive of: signs and symptoms of disease, individual treatment histories, local water, sanitation and hygiene (WASH)-related factors and malacological surveillance, with molecular characterisation of specimens...
February 27, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28229042/an-investigation-of-parasitic-infections-and-review-of-molecular-characterization-of-the-intestinal-protozoa-in-nonhuman-primates-in-china-from-2009-to-2015
#12
Junqiang Li, Haiju Dong, Rongjun Wang, Fuchang Yu, Yayun Wu, Yankai Chang, Chenrong Wang, Meng Qi, Longxian Zhang
Parasites are a well-known threat to nonhuman primate (NHP) populations, and potentially cause zoonotic diseases in humans. In this study, the basic data was provided of the parasites in NHPs and the molecular characterization of the Enterocytozoon bieneusi, Giardia duodenalis, Cryptosporidium spp., and Entamoeba spp. were reviewed, which were found in these samples. A total of 3349 fecal samples were collected from 34 species reared at 17 districts in zoos, farms, free-range, or research laboratories, and examined microscopically...
April 2017: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/28224032/prevalence-of-intestinal-parasites-in-referred-individuals-to-the-medical-centers-of-tonekabon-city-mazandaran-province
#13
Samira Shahdoust, Maryam Niyyati, Ali Haghighi, Eznoallah Azargashb, Mohammad Reza Khataminejad
AIM: The aim of the present study was to determine the prevalence of intestinal parasites and their relation with socio-demographic data in referred individuals to the medical centers in Tonekabon, Mazandaran province, 2015. BACKGROUND: Due to the climatic and ecological conditions in Mazandaran province, determination of the status of intestinal parasites among referred individuals to the medical centers of Tonekabon city can help researchers and healthcare services to prevent and/or control of parasitic infection in this region...
December 2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28223178/direct-experimental-manipulation-of-intestinal-cells-in-ascaris-suum-with-minor-influences-on-the-global-transcriptome
#14
Bruce A Rosa, Samantha N McNulty, Makedonka Mitreva, Douglas P Jasmer
Ascaris suum provides a powerful model for studying parasitic nematodes, including individual tissues such as the intestine, an established target for anthelmintic treatments. Here, we add a valuable experimental component to our existing functional, proteomic, transcriptomic and phylogenomic studies of the Ascaris suum intestine, by developing a method to manipulate intestinal cell functions via direct delivery of experimental treatments (in this case, double-stranded (ds)RNA) to the apical intestinal membrane...
February 20, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28222192/blastocystis-subtyping-and-its-association-with-intestinal-parasites-in-children-from-different-geographical-regions-of-colombia
#15
Juan David Ramírez, Carolina Flórez, Mario Olivera, María Consuelo Bernal, Julio Cesar Giraldo
Blastocystis is a common enteric protist colonizing probably more than 1 billion people with a large variety of non-human hosts. Remarkable genetic diversity has been observed, leading to the subdivision of the genus into multiple subtypes (ST), some of which are exclusively found in non-human hosts. The aim of this study was to determine the distribution of Blastocystis STs/18S alleles in symptomatic (abdominal pain, anal pruritus, diarrhea, headache, nauseas and/or vomit) and asymptomatic children from nine geographical regions of Colombia...
2017: PloS One
https://www.readbyqxmd.com/read/28214519/detection-and-quantification-of-soil-transmitted-helminths-in-environmental-samples-a-review-of-current-state-of-the-art-and-future-perspectives
#16
REVIEW
Isaac Dennis Amoah, Gulshan Singh, Thor Axel Stenström, Poovendhree Reddy
It is estimated that over a billion people are infected with soil-transmitted helminths (STHs) globally with majority occurring in tropical and subtropical regions of the world. The roundworm (Ascaris lumbricoides), whipworm (Trichuris trichiura), and hookworms (Ancylostoma duodenale and Necator americanus) are the main species infecting people. These infections are mostly gained through exposure to faecally contaminated water, soil or contaminated food and with an increase in the risk of infections due to wastewater and sludge reuse in agriculture...
May 2017: Acta Tropica
https://www.readbyqxmd.com/read/28212668/association-of-community-sanitation-usage-with-soil-transmitted-helminth-infections-among-school-aged-children-in-amhara-region-ethiopia
#17
William E Oswald, Aisha E P Stewart, Michael R Kramer, Tekola Endeshaw, Mulat Zerihun, Berhanu Melak, Eshetu Sata, Demelash Gessese, Tesfaye Teferi, Zerihun Tadesse, Birhan Guadie, Jonathan D King, Paul M Emerson, Elizabeth K Callahan, Matthew C Freeman, W Dana Flanders, Thomas F Clasen, Christine L Moe
BACKGROUND: Globally, in 2010, approximately 1.5 billion people were infected with at least one species of soil-transmitted helminth (STH), Ascaris lumbricoides, Trichuris trichiura, hookworm (Ancylostoma duodenale and Necator americanus). Infection occurs through ingestion or contact (hookworm) with eggs or larvae in the environment from fecal contamination. To control these infections, the World Health Organization recommends periodic mass treatment of at-risk populations with deworming drugs...
February 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28212667/assessing-the-interruption-of-the-transmission-of-human-helminths-with-mass-drug-administration-alone-optimizing-the-design-of-cluster-randomized-trials
#18
Roy Anderson, Sam Farrell, Hugo Turner, Judd Walson, Christl A Donnelly, James Truscott
BACKGROUND: A method is outlined for the use of an individual-based stochastic model of parasite transmission dynamics to assess different designs for a cluster randomized trial in which mass drug administration (MDA) is employed in attempts to eliminate the transmission of soil-transmitted helminths (STH) in defined geographic locations. The hypothesis to be tested is: Can MDA alone interrupt the transmission of STH species in defined settings? Clustering is at a village level and the choice of clusters of villages is stratified by transmission intensity (low, medium and high) and parasite species mix (either Ascaris, Trichuris or hookworm dominant)...
February 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28209148/prevalence-and-distribution-of-soil-transmitted-helminth-infections-in-india
#19
Nasir Salam, Saud Azam
BACKGROUND: Understanding the prevalence of soil-transmitted helminth infections is necessary to plan control strategies and focus on highly endemic regions for preventive chemotherapy and improved sanitation facilities. India is known to be endemic for soil-transmitted helminth infections. METHODS: To understand the prevalence, spatial distribution and identify high-risk zones, a systematic search of published literature was carried out based on PRISMA guidelines from the year 2000 to 2015...
February 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28192710/rational-design-of-reversible-inhibitors-for-trehalose-6-phosphate-phosphatases
#20
Chunliang Liu, Debra Dunaway-Mariano, Patrick S Mariano
In some organisms, environmental stress triggers trehalose biosynthesis that is catalyzed collectively by trehalose 6-phosphate synthase, and trehalose 6-phosphate phosphatase (T6PP). T6PP catalyzes the hydrolysis of trehalose 6-phosphate (T6P) to trehalose and inorganic phosphate and is a promising target for the development of antibacterial, antifungal and antihelminthic therapeutics. Herein, we report the design, synthesis and evaluation of a library of aryl d-glucopyranoside 6-sulfates to serve as prototypes for small molecule T6PP inhibitors...
February 4, 2017: European Journal of Medicinal Chemistry
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