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https://www.readbyqxmd.com/read/29707488/intravenous-sotalol-for-conversion-of-atrial-flutter-in-infants
#1
Othman A Aljohani, James C Perry, Matthew R Williams
No abstract text is available yet for this article.
March 2018: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/29642718/psychotropic-pharmacotherapy-associated-with-qt-prolongation-among-veterans-with-posttraumatic-stress-disorder
#2
Eileen M Stock, John E Zeber, Catherine J McNeal, Javier E Banchs, Laurel A Copeland
BACKGROUND: In 2012, the Food and Drug Administration issued Drug Safety Communications on several drugs associated with QT prolongation and fatal ventricular arrhythmias. Among these was citalopram, a selective serotonin reuptake inhibitor (SSRI) approved for depression and commonly used for posttraumatic stress disorder (PTSD). Evaluation of the risk for QT prolongation among other psychotropic drugs for individuals with PTSD remains limited. OBJECTIVE: Explore psychotropic drugs associated with QT prolongation among veterans with PTSD...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29574456/modeling-short-qt-syndrome-using-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#3
Ibrahim El-Battrawy, Huan Lan, Lukas Cyganek, Zhihan Zhao, Xin Li, Fanis Buljubasic, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Wolfram-Hubertus Zimmermann, Jochen Utikal, Thomas Wieland, Ursula Ravens, Martin Borggrefe, Xiao-Bo Zhou, Ibrahim Akin
BACKGROUND: Short QT syndrome (SQTS), a disorder associated with characteristic ECG QT-segment abbreviation, predisposes affected patients to sudden cardiac death. Despite some progress in assessing the organ-level pathophysiology and genetic changes of the disorder, the understanding of the human cellular phenotype and discovering of an optimal therapy has lagged because of a lack of appropriate human cellular models of the disorder. The objective of this study was to establish a cellular model of SQTS using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)...
March 24, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29501761/uv-h-2-o-2-process-stability-and-pilot-scale-validation-for-trace-organic-chemical-removal-from-wastewater-treatment-plant-effluents
#4
David B Miklos, Rebecca Hartl, Philipp Michel, Karl G Linden, Jörg E Drewes, Uwe Hübner
This study investigated the removal of 15 trace organic chemicals (TOrCs) occurring at ambient concentrations from municipal wastewater treatment plant effluent by advanced oxidation using UV/H2 O2 at pilot-scale. Pseudo first-order rate constants (kobs ) for photolytic as well as combined oxidative and photolytic degradation observed at pilot-scale were validated with results from a bench-scale collimated beam device. No significant difference was determined between pilot- and lab-scale performance. During continuous pilot-scale operation at constant UV fluence of 800 mJ/cm2 and H2 O2 dosage of 10 mg/L, the removal of various TOrCs was investigated...
June 1, 2018: Water Research
https://www.readbyqxmd.com/read/29500139/assessing-the-risk-for-peripheral-neuropathy-in-patients-treated-with-dronedarone-compared-with-that-in-other-antiarrhythmics
#5
Chuntao Wu, Stephanie Tcherny-Lessenot, Wanju Dai, Yunxun Wang, Hayet Kechemir, Sampada Gandhi, Stephen Lin, Juhaeri Juhaeri
PURPOSE: There are few data on the risk for peripheral neuropathy associated with dronedarone, a newer antiarrhythmic medicine. The objective of this study was to assess whether dronedarone is potentially associated with an increased risk for peripheral neuropathy compared with other antiarrhythmics, including amiodarone, sotalol, flecainide, and propafenone. METHODS: The MarketScan database was used for identifying patients who were at least 18 years of age, had atrial fibrillation or flutter, and had not been diagnosed with peripheral neuropathy in the 180-day period prior to or on the date of the first prescription of an antiarrhythmic between July 20, 2009, and December 31, 2011...
March 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29487686/safety-and-efficacy-of-inpatient-initiation-of-dofetilide-versus-sotalol-for-atrial-fibrillation
#6
Bharath Yarlagadda, Venkat Vuddanda, Tawseef Dar, Mohammad-Ali Jazayeri, Valay Parikh, Mohit K Turagam, Madhav Lavu, Sindhu Reddy Avula, Donita Atkins, Sudharani Bommana, Rakesh Gopinathannair, Madhu Reddy Yeruva, Dhanunjaya Lakkireddy
Background: We sought to investigate and compare the safety and efficacy of two commonly used antiarrhythmic drugs, Dofetilide (DF) and Sotalol (SL), during inpatient drug initiation in patients with symptomatic atrial fibrillation (AF). Methods: We performed a single center retrospective study of consecutive patients, admitted for initiation of either DF or SL, for AF between 2012 and 2015. Rates of successful cardioversion, QT interval prolongation, adverse events and drug discontinuations were calculated and compared...
December 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29485248/effects-of-combination-of-sotalol-and-verapamil-on-initiation-maintenance-and-termination-of-ventricular-fibrillation-in-swine-hearts
#7
Qi Jin, Liqun Wu, Derek J Dosdall, Li Li, Jack M Rogers, Raymond E Ideker, Jian Huang
INTRODUCTION: Sotalol and verapamil alone reduce reentry incidence during ventricular fibrillation (VF). We tested whether the combination of these two drugs had a synergistic effect on initiation, maintenance, and termination of VF. METHODS: Six open-chest pigs received intravenous sotalol (1.5 mg/kg) followed by verapamil (0.136 mg/kg). VF threshold (VFT) was determined by a burst pacing protocol. Two 20 seconds episodes of VF were recorded from a 21 × 24 unipolar electrode plaque on the lateral posterior left ventricular epicardium before and after each drug...
June 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29473523/drug-induced-qt-interval-prolongation-in-the-intensive-care-unit
#8
Cecilia Villa Etchegoyen, Guillermo Alberto Keller, Sebastian Mrad, Sixuan Cheng, Guillermo Di Girolamo
BACKGROUND: The most common acquired cause of Long QT syndrome (LQTS) is drug induced QT interval prolongation. It is an electrophysiological entity, which is characterized by an extended duration of the ventricular repolarization. Reflected as a prolonged QT interval in a surface ECG, this syndrome increases the risk for polymorphic ventricular tachycardia (Torsade de Pointes) and sudden death. METHOD: Bibliographic databases as MEDLINE and EMBASE, reports and drug alerts from several regulatory agencies (FDA, EMEA, ANMAT) and drug safety guides (ICH S7B, ICH E14) were consulted to prepare this article...
2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29462777/effects-of-water-warming-and-acidification-on-bioconcentration-metabolization-and-depuration-of-pharmaceuticals-and-endocrine-disrupting-compounds-in-marine-mussels-mytilus-galloprovincialis
#9
Albert Serra-Compte, Ana Luisa Maulvault, Carolina Camacho, Diana Álvarez-Muñoz, Damià Barceló, Sara Rodríguez-Mozaz, António Marques
Warming and acidification are expected impacts of climate change to the marine environment. Besides, organisms that live in coastal areas, such as bivalves, can also be exposed to anthropogenic pollutants like pharmaceuticals (PhACs) and endocrine disrupting compounds (EDCs). In this study, the effects of warming and acidification on the bioconcentration, metabolization and depuration of five PhACs (sotalol, sulfamethoxazole, venlafaxine, carbamazepine and citalopram) and two EDCs (methylparaben and triclosan) were investigated in the mussel species (Mytilus galloprovincialis), under controlled conditions...
May 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29460446/effect-of-sotalol-on-heart-rate-qt-interval-and-atrial-fibrillation-cycle-length-in-horses-with-atrial-fibrillation
#10
Annelies Decloedt, Barbara Broux, Dominique De Clercq, Piet Deprez, Glenn Van Steenkiste, Lisse Vera, Sofie Ven, Gunther van Loon
BACKGROUND: Based on its pharmacokinetic profile and electrophysiological effects in healthy horses, sotalol potentially could be used as a long-term PO antiarrhythmic drug in horses. OBJECTIVES: To evaluate the effect of sotalol on heart rate (HR), QT interval, atrial fibrillatory rate, and success of cardioversion in horses with naturally occurring chronic atrial fibrillation (AF). ANIMALS: Twenty-eight horses referred for transvenous electrical cardioversion of AF were treated with 2 mg/kg sotalol PO q12h for 3 days before cardioversion, and 13 horses underwent the same protocol without sotalol administration...
March 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29449809/digging-into-lipid-membrane-permeation-for-cardiac-ion-channel-blocker-d-sotalol-with-all-atom-simulations
#11
Kevin R DeMarco, Slava Bekker, Colleen E Clancy, Sergei Y Noskov, Igor Vorobyov
Interactions of drug molecules with lipid membranes play crucial role in their accessibility of cellular targets and can be an important predictor of their therapeutic and safety profiles. Very little is known about spatial localization of various drugs in the lipid bilayers, their active form (ionization state) or translocation rates and therefore potency to bind to different sites in membrane proteins. All-atom molecular simulations may help to map drug partitioning kinetics and thermodynamics, thus providing in-depth assessment of drug lipophilicity...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29377987/antiarrhythmic-effect-of-antazoline-in-experimental-models-of-acquired-short-and-long-qt-syndromes
#12
Christian Ellermann, Magdalena Sterneberg, Simon Kochhäuser, Dirk G Dechering, Michael Fehr, Lars Eckardt, Gerrit Frommeyer
Aims: Antazoline is a first-generation antihistamine with antiarrhythmic properties. This study examines potential electrophysiological effects of antazoline in short-QT-syndrome (SQTS) and long-QT-syndrome (LQTS). Methods and results: Sixty-five rabbit hearts were Langendorff-perfused. Action potential duration at 90% of repolarization (APD90), QT-interval, spatial dispersion (DISP), and effective refractory period (ERP) were measured. The IK, ATP-opener pinacidil (1 µM, n = 14) reduced APD90 (-14 ms, P < 0...
January 25, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29305400/effect-of-baseline-antiarrhythmic-drug-on-outcomes-with-ablation-in-ischemic-ventricular-tachycardia-a-vanish-substudy-ventricular-tachycardia-ablation-versus-escalated-antiarrhythmic-drug-therapy-in-ischemic-heart-disease
#13
Ratika Parkash, Isabelle Nault, Lena Rivard, Lorne Gula, Vidal Essebag, Pablo Nery, Stanley Tung, Jean-Marc Raymond, Laurence Sterns, Steve Doucette, George Wells, Anthony S L Tang, William G Stevenson, John L Sapp
BACKGROUND: The VANISH trial (Ventricular Tachycardia Ablation Versus Escalated Antiarrhythmic Drug Therapy in Ischemic Heart Disease) compared the effectiveness of escalated antiarrhythmic drug therapy to catheter ablation in patients with prior myocardial infarction, an implanted defibrillator, and ventricular tachycardia (VT). The effectiveness of these interventions in patients on sotalol versus amiodarone was compared. METHODS AND RESULTS: Analysis was conducted based on whether patients had recurrent VT, despite amiodarone (amio-refractory) or nonamiodarone drugs (sotalol-refractory)...
January 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29276907/-regulatory-adaptive-status-in-determining-the-effectiveness-of-bisoprololum-and-sotalolum-in-patients-with-hypertensive-disease-and-paroxysmal-supraventricular-tachycardia
#14
V G Tregubov, V M Pokrovsky, N M Nazhalkina
AIM: To determine efficacy of bisoprolol and sotalol treatments in patients with paroxysmal supraventricular tachycardia (SVT) and essential hypertension (EH) considering effects of these treatments on the regulatory adaptive status (RAS). MATERIALS AND METHODS: The study included 49 patients with paroxysmal SVT associated with stage II-III EH randomized to two groups of either bisoprolol (6.9±2.2 mg/day, n=25) or sotalol (162.5±46.2 mg/day, n=24) treatment. Lisinopril (14...
2017: Kardiologiia
https://www.readbyqxmd.com/read/29274391/electrophysiological-characteristics-and-pharmacological-sensitivity-of-two-lines-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-coming-from-two-different-suppliers
#15
Sonia Goineau, Vincent Castagné
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly used as preclinical tool for predicting drug-induced QT prolongation and arrhythmias. This study was conducted to assess the electrophysiological characteristics and the pharmacological sensitivity of two commercialized hiPSC-CMs. The baseline electrophysiological characteristics measured with a multi-electrode array (MEA) technology differ between Cor.4U and iCell2 : higher beat rate (+32bpm) and shorter field potential duration (FPD, -201ms) for Cor...
March 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29250266/intravenous-sotalol-reintroducing-a-forgotten-agent-to-the-electrophysiology-therapeutic-arsenal
#16
REVIEW
Syeda Atiqa Batul, Rakesh Gopinathannair
Sotalol is a racemic mixture possessing beta-blocker and class III anti arrhythmic properties. Approved by US food and drug administration (FDA) since 2009 based on its bioequivalence with oral sotalol, clinicians are less familiar with the potential uses of the intravenous form despite its re-launch in United States in 2015. Available literature suggests that intravenous sotalol in recommended doses can be safely administered in adult and pediatric population achieving rapid reliable therapeutic plasma concentration and without additional proarrhythmic effects when compared to its oral form as well as other antiarrhythmic medications...
February 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29250225/atrial-fibrillation-in-patients-with-congenital-heart-disease
#17
REVIEW
Tabitha G Moe, Victor A Abrich, Edward K Rhee
Advances in surgical techniques have led to the survival of most patients with congenital heart disease (CHD) up to their adulthood. During their lifetime, many of them develop atrial tachyarrhythmias due to atrial dilatation and scarring from surgical procedures. More complex defects and palliative repairs are linked to a higher incidence and earlier occurrence of arrhythmias. Atrial fibrillation (AF) is common in patients who have atrial septal defects repaired after age 55 and in patients with tetralogy of Fallot repaired after age 45...
June 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29246961/first-line-antiarrhythmic-transplacental-treatment-for-fetal-tachyarrhythmia-a-systematic-review-and-meta-analysis
#18
REVIEW
Tarek Alsaied, Shankar Baskar, Munes Fares, Fares Alahdab, Richard J Czosek, Mohammad Hassan Murad, Larry J Prokop, Allison A Divanovic
BACKGROUND: There is no consensus on the most effective and best tolerated first-line antiarrhythmic treatment for fetal tachyarrhythmia. The purpose of this systematic review and meta-analysis was to compare the efficacy, safety, and fetal-maternal tolerance of first-line monotherapies for fetal supraventricular tachycardia and atrial flutter. METHODS AND RESULTS: A comprehensive search of several databases was conducted through January 2017. Only studies that made a direct comparison between first-line treatments of fetal tachyarrhythmia were included...
December 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29208503/maternal-complications-induced-by-digoxin-treatment-of-fetal-tachycardia-a-retrospective-series-of-18-cases
#19
S Moatassim, S Touleimat, T Hazelzet, M D Brasseur, A Diguet, I Durand, E Verspyck
OBJECTIVE: To evaluate maternal tolerance to digoxin, used alone or associated to other antiarrhythmic drugs in the management of fetal tachycardia. PATIENTS AND METHODS: This retrospective study was conducted at Rouen University Hospital between January 2009 and July 2016. All women who have received a treatment by either digoxin alone or associated with another antiarrhythmic drug for fetal tachycardia were included in the study. Maternal cardiac and extracardiac adverse effects were reported and comparisons between electrocardiograms before and during treatment with digoxin alone were performed...
February 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29205742/trends-in-outpatient-anti-arrhythmic-prescriptions-for-atrial-fibrillation-and-left-atrial-ablation-in-australia-1997-2016
#20
Ifrah Khan, Hitesh C Patel, Shane Nanayakkara, Hariharan Raju, Aleksandr Voskoboinik, Justin A Mariani
BACKGROUND: An important aspect of atrial fibrillation (AF) management is the decision whether to adopt a rate or rhythm control strategy. Options for the latter include oral anti-arrhythmic drugs (AADs) or catheter ablation. AIM: We sought to describe the trends in rhythm control for AF in Australia between 1997 and 2016. METHODS: We conducted a retrospective study using prospectively collected data between 1997 - 2016 from the Pharmaceutical Benefit Scheme and Medicare Benefit Schedule websites, which respectively contain information pertaining to public AAD prescriptions and rebatable AF ablation procedures performed in the Australia...
December 5, 2017: Internal Medicine Journal
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