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https://www.readbyqxmd.com/read/29684862/antioxidant-effects-of-lycium-barbarum-polysaccharides-on-photoreceptor-degeneration-in-the-light-exposed-mouse-retina
#1
Liujiu Tang, Shuyin Bao, Yu Du, Zengyan Jiang, A O Wuliji, Xiang Ren, Chenghong Zhang, Haiying Chu, Li Kong, Haiying Ma
We assessed the neuroprotective effects of Lycium barbarum Polysaccharides (LBP) on photoreceptor degeneration and the mechanisms involved in oxidative stress in light-exposed mouse retinas. Mice were given a gavage of LBP (150 mg/kg or 300 mg/kg) or phosphate buffered saline (PBS) for 7 days before exposure to light (5000 lx for 24 h). We found that LBP significantly improved the electroretinography (ERG) amplitudes of the a- and b-waves that had been attenuated by light exposure. In addition, changes caused by light exposure including photoreceptor cell loss, nuclear condensation, an increased number of mitochondria vacuoles, outer membrane disc swelling and cristae fractures were distinctly ameliorated by LBP...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684588/extracellular-vesicle-mediated-long-range-communication-in-stressed-retinal-pigment-epithelial-cell-monolayers
#2
Navjot Shah, Masakii Ishii, Carlene Brandon, Zsolt Ablonczy, Jingwen Cai, Yutao Liu, James Chou, Bärbel Rohrer
Retinal pigment epithelium (RPE) alterations in age-related macular degeneration occur in patches, potentially involving long-distance communication between damaged and healthy areas. Communication along the epithelium might be mediated by extracellular vesicles (EVs). To test this hypothesis, EVs were collected from supernatants of polarized ARPE-19 and primary porcine RPE monolayers for functional and biochemical assays. EVs from oxidatively stressed donor cells reduced barrier function in recipient RPE monolayers when compared to control EVs...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684583/a-novel-rpe65-inhibitor-cu239-suppresses-visual-cycle-and-prevents-retinal-degeneration
#3
Younghwa Shin, Gennadiy Moiseyev, Konstantin Petrukhin, Christopher L Cioffi, Parthasarathy Muthuraman, Yusuke Takahashi, Jian-Xing Ma
The retinoid visual cycle is an ocular retinoid metabolism specifically dedicated to support vertebrate vision. The visual cycle serves not only to generate light-sensitive visual chromophore 11-cis-retinal, but also to clear toxic byproducts of normal visual cycle (i.e. all-trans-retinal and its condensation products) from the retina, ensuring both the visual function and the retinal health. Unfortunately, various conditions including genetic predisposition, environment and aging may attribute to a functional decline of the all-trans-retinal clearance...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684405/moderate-perinatal-thyroid-hormone-insufficiency-alters-visual-system-function-in-adult-rats
#4
William K Boyes, Laura Degn, Barbara Jane George, Mary E Gilbert
Thyroid hormone (TH) is critical for many aspects of neurodevelopment and can be disrupted by a variety of environmental contaminants. Sensory systems, including audition and vision are vulnerable to TH insufficiencies, but little data are available on visual system development at less than severe levels of TH deprivation. The goal of the current experiments was to explore dose-response relations between graded levels of TH insufficiency during development and the visual function of adult offspring. Pregnant Long Evans rats received 0 or 3 ppm (Experiment 1), or 0, 1, 2, or 3 ppm (Experiment 2) of propylthiouracil (PTU), an inhibitor of thyroid hormone synthesis, in drinking water from gestation day (GD) 6 to postnatal day (PN) 21...
April 20, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29684364/inhibition-of-mitochondrial-fission-preserves-photoreceptors-after-retinal-detachment
#5
Xiangjun She, Xinmin Lu, Tong Li, Junran Sun, Jian Liang, Yuanqi Zhai, Shiqi Yang, Qing Gu, Fang Wei, Hong Zhu, Fenghua Wang, Xueting Luo, Xiaodong Sun
Photoreceptor degeneration is a leading cause of visual impairment worldwide. Separation of neurosensory retina from the underlying retinal pigment epithelium is a prominent feature preceding photoreceptor degeneration in a variety of retinal diseases. Although ophthalmic surgeries have been well developed to restore retinal structures, post-op patients usually experience progressive photoreceptor degeneration and irreversible vision loss that is incurable at present. Previous studies point to a critical role of mitochondria-mediated apoptotic pathway in photoreceptor degeneration, but the upstream triggers remain largely unexplored...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29684094/quantitative-analyses-of-factors-related-to-anxiety-and-depression-in-patients-with-retinitis-pigmentosa
#6
Mayumi Sainohira, Takehiro Yamashita, Hiroto Terasaki, Shozo Sonoda, Kazunori Miyata, Yusuke Murakami, Yasuhiro Ikeda, Takeshi Morimoto, Takao Endo, Takashi Fujikado, Junko Kamo, Taiji Sakamoto
The purpose of this study is to determine the factors related to anxiety and depression in patients with retinitis pigmentosa (RP). The status of anxiety and depression was determined in RP patients with the Hospital Anxiety and Depression Scale (HADS) questionnaire which consisted of subscales for HADS-anxiety (HADS-A) and HADS-depression (HADS-D). The vision-specific quality of life (VSQOL) was assessed with the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ25). The correlations between the HADS-A or HADS-D scores and vision-related clinical parameters such as the best-corrected visual acuity (BCVA), Functional Acuity Score, Functional Field Score, Functional Vision Score, the NEI- VFQ25 subscale score were determined...
2018: PloS One
https://www.readbyqxmd.com/read/29683985/accommodative-behavior-of-young-eyes-wearing-multifocal-contact-lenses
#7
Basal H Altoaimi, Meznah S Almutairi, Pete S Kollbaum, Arthur Bradley
SIGNIFICANCE: The effectiveness of multifocal contact lenses (MFCLs) at slowing myopia progression may hinge on the accommodative behavior of young eyes fit with these presbyopic style lenses. Can they remove hyperopic defocus? Convergence accommodation as well as pupil size and the zonal geometry are likely to contribute to the final accommodative responses. PURPOSE: The aim of this study was to examine the accommodation behavior of young adult eyes wearing MFCLs and the effectiveness of these MFCLs at removing foveal hyperopic defocus when viewing near targets binocularly...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29683983/fluorescein-angiography-indications-changes-after-optical-coherence-tomography-and-antiangiogenics
#8
Sonia C Labrador-Velandia, María R Sanabria
SIGNIFICANCE: The present study provides quantitative data regarding the change of indications of fluorescein angiography in a tertiary hospital. Exhaustively compiled data over more than 10 years concerning all the angiographic studies including diagnosis, first-visit/follow-up, possible relation with antiangiogenics approval, and optic coherence tomography (OCT) are presented. PURPOSE: The aim of this study was to determine the frequency and indications of fluorescein angiography before and after OCT and anti-vascular endothelial growth factor (anti-VEGF) treatment implantation...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29683519/children-with-mucopolysaccharidosis-risk-progressive-visual-dysfunction-despite-haematopoietic-stem-cell-transplants
#9
Kristina Teär Fahnehjelm, Monica Olsson, Enping Chen, Jürg Hengstler, Karin Naess, Jacek Winiarski
AIM: This prospective study assessed the long-term ocular and visual outcomes of children with mucopolysaccharidoses type I Hurler syndrome (MPS IH) who were treated with haematopoietic stem cell transplants (HSCT). METHODS: Clinical ophthalmological assessments were performed on eight patients at the St Erik Eye Hospital, Stockholm, Sweden, from 2001-2018: The median age at diagnosis and HSCT were 12.2 (range 5.0-16.4) and 16.7 (8.0-20.4) months. The last eye examination was at a median of 13...
April 23, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29682916/pediatric-uveitis
#10
Nicole Shu-Wen Chan, Jessy Choi, Chui Ming Gemmy Cheung
Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment. Anterior uveitis is the most common type of uveitis in children; the prevalence of intermediate, posterior, and panuveitis varies geographically and among ethnic groups. Regarding etiology, most cases of pediatric uveitis are idiopathic but can be due to systemic inflammatory disorders, infections, or a manifestation of masquerade syndrome...
April 23, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29682582/vitamin-d-3-protects-against-diabetic-retinopathy-by-inhibiting-high-glucose-induced-activation-of-the-ros-txnip-nlrp3-inflammasome-pathway
#11
Li Lu, Qianyi Lu, Wei Chen, Jingwen Li, Chunxia Li, Zhi Zheng
Purpose: This study aimed to evaluate the mechanisms underlying the effects of 1,25-dihydroxyvitamin D (vitamin D3 ) on diabetes-induced retinal vascular damage and retinal vascular endothelial cell apoptosis. Methods: Diabetic and control rats were randomly assigned to receive vitamin D3 or vehicle for 6 months. Additionally, human retinal microvascular endothelial cells (HRMECs) were incubated in normal or high-glucose medium with or without vitamin D3 . Morphological changes in retinal tissues and retinal vascular permeability were examined, and cellular apoptosis was detected by fluorescence staining...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29682578/analysis-of-changes-in-retinal-thickness-in-type-2-diabetes-without-diabetic-retinopathy
#12
Jing Jiang, Yan Liu, Yingchao Chen, Bo Ma, Yiwen Qian, Zhenzhen Zhang, Dongqing Zhu, Zhiliang Wang, Xiaofang Xu
Objective: To examine the changes in retinal thickness of patients with diabetes without DR. Designs: A randomization, crossover, retrospective practice. Participants: 43 diabetic patients and 43 ethnic-, age-, and sex-matched controls. Methods: Full retinal thicknesses of ten areas were assessed using spectral domain optical coherence tomography. Confounding variables, such as age, gender, and glycated haemoglobin (HbA1c) level, were assessed by regression analysis...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29682502/frontiers-of-complex-disease-mechanisms-membrane-surface-tension-may-link-genotype-to-phenotype-in-glaucoma
#13
Howard R Petty
Although many monogenic diseases are understood based upon structural changes of gene products, less progress has been made concerning polygenic disease mechanisms. This article presents a new interdisciplinary approach to understand complex diseases, especially their genetic polymorphisms. I focus upon primary open angle glaucoma (POAG). Although elevated intraocular pressure (IOP) and oxidative stress are glaucoma hallmarks, the linkages between these factors and cell death are obscure. Reactive oxygen species (ROS) promote the formation of oxidatively truncated phosphoglycerides (OTP), free fatty acids, lysophosphoglycerides, oxysterols, and other chemical species that promote membrane disruption and decrease membrane surface tension...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29682340/a-brief-review-on-the-pathological-role-of-decreased-blood-flow-affected-in-retinitis-pigmentosa
#14
REVIEW
Yi Jing Yang, Jun Peng, Deng Ying, Qing Hua Peng
Retinitis pigmentosa (RP) represents a clinically and genetically heterogeneous disease characterized by progressive photoreceptor loss. In recent years, research has been rarely made in blood flow affected in RP. The specific mechanism of blood flow affected in RP is not completely clear. A number of studies indicated that the decreased blood flow was related to RP. According to clinical observation and treatment experience, Chinese medicine considered that blood stasis runs throughout the RP disease progression, and the blood stasis corresponding to Chinese herbal medicine has a positive effect on the clinical treatment of RP...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29682153/antioxidant-and-anti-inflammatory-effects-of-blueberry-anthocyanins-on-high-glucose-induced-human-retinal-capillary-endothelial-cells
#15
Wuyang Huang, Zheng Yan, Dajing Li, Yanhong Ma, Jianzhong Zhou, Zhongquan Sui
Blueberries possess abundant anthocyanins, which benefit eye health. The purpose of this study was to explore the protective functional role of blueberry anthocyanin extract (BAE) and its predominant constituents, malvidin (Mv), malvidin-3-glucoside (Mv-3-glc), and malvidin-3-galactoside (Mv-3-gal), on high glucose- (HG-) induced injury in human retinal capillary endothelial cells (HRCECs). The results showed that BAE, Mv, Mv-3-glc, and Mv-3-gal enhanced cell viability ( P < 0.05 versus the HG group at 24 h); decreased the reactive oxygen species (ROS, P < 0...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29681857/a-synthesized-glucocorticoid-induced-leucine-zipper-peptide-inhibits-retinal-m%C3%A3-ller-cell-gliosis
#16
Ruiping Gu, Xinyi Ding, Wenyi Tang, Boya Lei, Chen Jiang, Gezhi Xu
Purpose: The anti-inflammatory activities of protein glucocorticoid-induced leucine zipper (GILZ) have been demonstrated in vivo and in vitro . Here, we examined the potential effect of a synthetic peptide derived from the leucine zipper motif and proline-rich region of GILZ on suppressing inflammatory responses in primary cultured rat Müller cells. Methods: Peptides were selected from amino acids 98-134 of the GILZ protein (GILZ-p). Solid-phase peptide synthesis was used to generate the cell-penetrating peptide TAT, which was bound to the amino terminus of GILZ-p...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29681844/topical-corticosteroid-resolved-rubeosis-iridis-with-neovascular-glaucoma-caused-by-noninfectious-granulomatous-uveitis
#17
Daisuke Sora, Kei Takayama, Manzo Taguchi, Tomohito Sato, Yutaka Sakurai, Takayuki Kanda, Masaru Takeuchi
Purpose: We report a case of topical corticosteroid treatment-resolved rubeosis iridis with neovascular glaucoma (NVG) caused by noninfectious granulomatous uveitis. Case Report: A 61-year-old woman with left ocular pain and blurred vision was referred to our department. Visual acuity and intraocular pressure (IOP) were 20/60 and 37 mm Hg in the left eye, respectively. Inflammatory cells, hyphema, and rubeosis iridis were observed. All laboratory tests, including multiplex polymerase chain reaction for infection using aqueous humor, were negative, and there was neither retinal occlusive vasculitis nor retinal ischemia in the fundus...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681842/adult-coats-disease-presenting-as-subfoveal-nodule
#18
Salim Z Asaad, Nazimul Hussain
A 21-year-old female presented with decreased vision in the right eye. Best corrected visual acuity was 6/60 in the right eye and 6/6 in the left eye. Funduscopy of the right eye revealed a subfoveal nodule with surrounding exudates and temporal peripheral retinal vessel telangiectasia with exudation. The patient underwent retinal laser in the areas of telangiectatic vessels and capillary non-perfusion as seen on fundus fluorescein angiography. It was combined with an intravitreal injection of bevacizumab which was repeated twice at monthly intervals...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681839/long-term-follow-up-of-congenital-simple-hamartoma-of-the-retinal-pigment-epithelium-a-case-report
#19
Yuka Ito, Masahito Ohji
Background: Congenital simple hamartoma of the retinal pigment epithelium (CSHRPE) is a rare benign tumor of the retinal pigment epithelium characterized by a focal, darkly pigmented nodule in the macular lesion in healthy persons. We report a case of CSHRPE with long-term follow-up. Case: A 41-year-old Japanese woman was incidentally discovered to have a dark lesion on the fundus of the left eye. We evaluated the patient by measuring her best-corrected visual acuity (BCVA) and by slit-lamp biomicroscopy, fundus color photography, and optical coherence tomography (OCT) over a 10-year period...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681837/unusual-case-of-vogt-koyanagi-harada-disease-associated-with-sapho-syndrome-a-case-report
#20
Miyuki Hasegawa, Akira Fukutomi, Akiko Jinno, Kyoko Fujita, Motohiro Kamei
A 66-year-old Japanese woman who was diagnosed with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome presented with bilateral blurred vision 4 months prior to visiting our hospital. She had visited a local ophthalmology clinic first. She was diagnosed with conjunctivitis and was prescribed antibacterial eye drops. The symptoms persisted in spite of treatment. She was then referred to our hospital. At her initial visit, the visual acuities were 0.6 in both eyes. A slit-lamp examination revealed bilateral shallow anterior chamber, and intraocular pressures of 18 mm Hg in the right eye and 16 mm Hg in the left eye...
January 2018: Case Reports in Ophthalmology
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