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Abe and nmda

Michael D Grannan, Catharine A Mielnik, Sean P Moran, Robert W Gould, Jacob Ball, Zhuoyan Lu, Michael Bubser, Amy J Ramsey, Masahito Abe, Hyekyung P Cho, Kellie D Nance, Anna L Blobaum, Colleen M Niswender, P Jeffrey Conn, Craig W Lindsley, Carrie K Jones
Abnormalities in the signaling of the N-methyl-d-aspartate subtype of the glutamate receptor (NMDAR) within cortical and limbic brain regions are thought to underlie many of the complex cognitive and affective symptoms observed in individuals with schizophrenia. The M1 muscarinic acetylcholine receptor (mAChR) subtype is a closely coupled signaling partner of the NMDAR. Accumulating evidence suggests that development of selective positive allosteric modulators (PAMs) of the M1 receptor represent an important treatment strategy for the potential normalization of disruptions in NMDAR signaling in patients with schizophrenia...
October 5, 2016: ACS Chemical Neuroscience
Makoto Okazawa, Haruka Abe, Shigetada Nakanishi
In the early postnatal period, cerebellar granule cells exhibit an activity-dependent downregulation of a set of immaturation genes involved in cell growth and migration and are shifted to establishment of a mature network formation. Through the use of a granule cell culture and both pharmacological and RNA interference (siRNA) analyses, the present investigation revealed that the downregulation of these immaturation genes is controlled by strikingly unified signaling mechanisms that operate sequentially through the stimulation of AMPA and NMDA receptors, tetrodotoxin-sensitive Na(+) channels and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)...
May 13, 2016: Biochemical and Biophysical Research Communications
Shigeyuki Chaki, Toshiharu Shimazaki, Jun-Ichi Karasawa, Takeshi Aoki, Ayaka Kaku, Michihiko Iijima, Daiji Kambe, Shuji Yamamoto, Yasunori Kawakita, Tsuyoshi Shibata, Kumi Abe, Taketoshi Okubo, Yoshinori Sekiguchi, Shigeru Okuyama
RATIONALE: Since the hypofunction of the N-methyl-D-aspartate (NMDA) receptor is known to be involved in the pathophysiology of schizophrenia, the enhancement of NMDA receptor function through glycine modulatory sites is expected to be a useful approach for the treatment of schizophrenia. OBJECTIVES: We investigated the efficacy of a glycine transporter 1 (GlyT1) inhibitor that potentiates NMDA receptor function by increasing synaptic glycine levels in animal models for cognitive dysfunction and negative symptoms, both of which are poorly managed by current antipsychotics...
August 2015: Psychopharmacology
T Kato, Y Abe, S Hirokawa, Y Iwakura, M Mizuno, H Namba, H Nawa
Neuregulin-1 (NRG1) is a well-recognized risk gene for schizophrenia and is often implicated in the neurodevelopmental hypothesis of this illness. Alternative splicing and proteolytic processing of the NRG1 gene produce more than 30 structural variants; however, the neuropathological roles of individual variants remain to be characterized. On the basis of the neurodevelopmental hypothesis of schizophrenia, we administered eNRG1 (0.1~1.0 μg/g), a core epidermal growth factor-like (EGF) domain common for all splicing NRG1 variants, to neonatal mice and compared their behavioral performance with mice challenged with a full mature form of type 1 NRG1 variant...
2015: Current Molecular Medicine
Takato Abe, Masataka Suzuki, Jumpei Sasabe, Shinichi Takahashi, Miyuki Unekawa, Kyoko Mashima, Takuya Iizumi, Kenji Hamase, Ryuichi Konno, Sadakazu Aiso, Norihiro Suzuki
D-Serine is known to be essential for the activation of the N-methyl-D-aspartate (NMDA) receptor in the excitation of glutamatergic neurons, which have critical roles in long-term potentiation and memory formation. D-Serine is also thought to be involved in NMDA receptor-mediated neurotoxicity. The deletion of serine racemase (SRR), which synthesizes D-serine from L-serine, was recently reported to improve ischemic damage in mouse middle cerebral artery occlusion model. However, the cell type in which this phenomenon originates and the regulatory mechanism for D-/L-serine remain elusive...
December 2014: Journal of Cerebral Blood Flow and Metabolism
Asako Gondo, Takanori Shinotsuka, Ayaka Morita, Yoichiro Abe, Masato Yasui, Mutsuo Nuriya
Epilepsy is characterized by the abnormal activation of neurons in the cerebral cortex, but the molecular and cellular mechanisms contributing to the development of recurrent seizures are largely unknown. Recently, the critical involvement of astrocytes in the pathophysiology of epilepsy has been proposed. However, the nature of plastic modulations of astrocytic proteins in the epileptic cortex remains poorly understood. In this study, we utilized the zero magnesium in vitro model of epilepsy and examined the potential molecular changes of cortical astrocytes, focusing specifically on endfeet, where specialized biochemical compartments exist...
October 31, 2014: Journal of Biological Chemistry
Saleh A Naser, Almatmed Abdelsalam, Saisathya Thanigachalam, Abed S Naser, Karel Alcedo
Digestive diseases play major role in development and complications of other disorders including diabetes. For example, Crohn's disease (CD) is an inflammatory bowel disease associated with Mycobacterium avium subspecies paratuberculosis. The inflammation is a complex process that involves the activity of both innate and adaptive immune responses. CD lesions are primarily due to T cell response, however; innate immune response has a significant role in initiating its pathogenesis. Toll-like receptors and NOD-like receptors promote the activity of nuclear factor (NF)-κB pathway for cytokines production...
August 15, 2014: World Journal of Diabetes
Emuri Abe, Florian Ricard, François Darrouzain, Jean Claude Alvarez
Methoxetamine is a new ketamine derivative designer drug which has recently become available via the Internet marketed as "legal ketamine". It is a new dissociative recreational drug, acting as an NMDA receptor antagonist and dopamine reuptake inhibitor. The objective of this study was to develop on-line automated sample preparation using a TurboFlow device coupled with liquid chromatography with ion-trap mass spectrometric detection for measurement of methoxetamine in human plasma. Samples (100 μL) were vortex mixed with internal standard solution (ketamine-d4 in acetonitrile)...
January 2013: Analytical and Bioanalytical Chemistry
Haruka Abe, Makoto Okazawa, Shigetada Nakanishi
In maturing postnatal cerebellar granule cells, the Etv1/Er81 transcription factor is induced by sequential activity-dependent mechanisms through stimulation of AMPA and NMDA receptors, voltage-dependent Nav1.2 Na(+) channels, and voltage-dependent Ca(2+) channels. Etv1 then up-regulates a battery of maturation genes involved in the cerebellar circuitry. In this process, BDNF is also induced and participates in the up-regulation of these maturation genes. Using cultures of granule cells, we addressed how the activity-dependent and BDNF signaling mechanisms converge on the regulation of the representative NR2C NMDA receptor and Tiam1 maturation genes...
May 29, 2012: Proceedings of the National Academy of Sciences of the United States of America
Miyako Morooka, Kazuo Kubota, Ryogo Minamimoto, Mariko Furuhata, Tadashi Abe, Kimiteru Ito, Momoko Okasaki, Kenji Ishii, Kiichi Ishiwata
No abstract text is available yet for this article.
April 2012: Clinical Nuclear Medicine
Kitaro Onozawa, Yuki Yagasaki, Yumi Izawa, Hiroyuki Abe, Yoriko Kawakami
BACKGROUND: We previously demonstrated nociceptive discharges to be evoked by mechanical noxious stimulation in the prefrontal cortex (PFC). The nociceptive responses recorded in the PFC are conceivably involved in the affective rather than the sensory-discriminative dimension of pain. The PFC receives dense projection from the limbic system. Monosynaptic projections from the basolateral nucleus of the amygdala (BLA) to the PFC are known to produce long-lasting synaptic plasticity. We examined effects of high frequency stimulation (HFS) delivered to the BLA on nociceptive responses in the rat PFC...
2011: BMC Neuroscience
V Hajhashemi, M Abed-Natanzi
This study was designed to assess the effect of five common anticonvulsant drugs on naloxone-precipitated withdrawal syndrome in morphine-dependent mice. Male mice (25-35 g) were made dependent by increasing doses of morphine (30-90 mg/kg). At least three doses of phenytoin, carbamazepine, sodium valproate, lamotrigine and topiramate were injected i.p. to morphine-dependent mice 45 min prior to induction of withdrawal syndrome by naloxone (5 mg/kg, i.p.). Control animals received vehicle. Number of jumpings was counted and ptosis, tremor, piloerection and diarrhea were checked in a 30 min period started just after naloxone injection...
January 2011: Research in Pharmaceutical Sciences
Josef Anrather, Eduardo F Gallo, Takayuki Kawano, Marcello Orio, Takato Abe, Camile Gooden, Ping Zhou, Costantino Iadecola
Cyclooxygenases (COX) are prostanoid synthesizing enzymes constitutively expressed in the brain that contribute to excitotoxic neuronal cell death. While the neurotoxic role of COX-2 is well established and has been linked to prostaglandin E(2) synthesis, the role of COX-1 is not clearly understood. In a model of N-Methyl-D-aspartic acid (NMDA) induced excitotoxicity in the mouse cerebral cortex we found a distinctive temporal profile of COX-1 and COX-2 activation where COX-1, located in microglia, is responsible for the early phase of prostaglandin E(2) synthesis (10 minutes after NMDA), while both COX-1 and COX-2 contribute to the second phase (3-24 hours after NMDA)...
2011: PloS One
Haruka Abe, Makoto Okazawa, Shigetada Nakanishi
In the postnatal period, cerebellar granule cells express a set of the maturation gene battery in an activity-dependent manner and establish synaptic function in the cerebellar circuitry. Using primary cultures combined with specific inhibition of signaling cascades, the present investigation revealed that the expression of the maturation genes, including the NMDA glutamate receptor NR2C and GABA(A) receptor GABA(A)Rα6 genes, is controlled by strikingly unified signaling mechanisms that operate sequentially through stimulation of AMPA and NMDA receptors, Na(+) channels [voltage-gated Na channel type II (Nav1...
July 26, 2011: Proceedings of the National Academy of Sciences of the United States of America
Kimihiko Shibata, Noriko Sugaya, Wakana Ono, Katsumasa Abe, Shouji Takahashi, Yoshio Kera
We describe a method for the detection and quantification of D-aspartate N-methyltransferase activity. The enzyme catalyzes the S-adenosyl-L-methionine-dependent N-methylation of D-aspartate to form N-methyl-D-aspartate (NMDA). NMDA is detected directly by high-performance liquid chromatography (HPLC) of their (+)- and/or (-)-1-(9-fluorenyl)ethyl chloroformate fluorescent derivatives. The NMDA production in the assay mixture is linearly proportional to the incubation time and the amount of tissue homogenate...
November 1, 2011: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Shinji Matsumura, Shunji Kunori, Tamaki Mabuchi, Tayo Katano, Takanobu Nakazawa, Tetsuya Abe, Masahiko Watanabe, Tadashi Yamamoto, Emiko Okuda-Ashitaka, Seiji Ito
Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) is a key mediator of long-term potentiation (LTP), which can be triggered by N-methyl-d-aspartate (NMDA) receptor-mediated Ca(2+) influx. We previously demonstrated that Fyn kinase-mediated phosphorylation of NR2B subunits of NMDA receptors at Tyr1472 in the dorsal horn was involved in a neuropathic pain state even 1 week after nerve injury. Here we show that Y1472F-KI mice with a knock-in mutation of the Tyr1472 site to phenylalanine did not exhibit neuropathic pain induced by L5 spinal nerve transection, whereas they did retain normal nociceptive responses and induction of inflammatory pain...
September 2010: European Journal of Neuroscience
Yasuo Ito, Tatsuya Abe, Ryo Tomioka, Tetsuo Komori, Nobuo Araki
A 19-year-old female in her 2nd trimester (17 weeks) of pregnancy became irritable a few days before admission. She became unable to open her mouth and could not talk. She was admitted to the psychiatric hospital due to a rapid change in behavior and a consciousness disturbance. She was diagnosed as having schizophrenia by a psychiatrist. Her EEG showed diffuse high voltage and slow waves. Acute encephalitis was then suspected. Her past and family histories were not suggestive of viral infection. On physical examination, she had a low grade fever...
February 2010: Rinshō Shinkeigaku, Clinical Neurology
H Inoue, H Yamasue, M Tochigi, M Suga, Y Iwayama, O Abe, H Yamada, M A Rogers, S Aoki, T Kato, T Sasaki, T Yoshikawa, K Kasai
The glutamate system including N-methyl-d-aspartate (NMDA) affects synaptic formation, plasticity and maintenance. Recent studies have shown a variable (GT)n polymorphism in the promoter region of the NMDA subunit gene (GRIN2A) and a length-dependent inhibition of transcriptional activity by the (GT)n repeat. In the present study, we examined whether the GRIN2A polymorphism is associated with regional brain volume especially in medial temporal lobe structures, in which the NMDA-dependent synaptic processes have been most extensively studied...
April 2010: Genes, Brain, and Behavior
S L Stvolinsky, E R Bulygina, T N Fedorova, K Meguro, T Sato, O V Tyulina, H Abe, A A Boldyrev
Two novel derivatives of carnosine--(S)-trolox-L-carnosine (STC) and (R)-trolox-L-carnosine (RTC) are characterized in terms of their antioxidant and membrane-stabilizing activities as well as their resistance to serum carnosinase. STC and RTC were synthesized by N-acylation of L-carnosine with (S)- and (R)-trolox, respectively. STC and RTC were found to react more efficiently with 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and protect serum lipoproteins from Fe(2+)-induced oxidation more successfully than carnosine and trolox...
April 2010: Cellular and Molecular Neurobiology
John G Partridge, Megan J Janssen, David Y T Chou, Ken Abe, Zofia Zukowska, Stefano Vicini
Although rare, interneurons are pivotal in governing striatal output by extensive axonal arborizations synapsing on medium spiny neurons. Using a genetically modified mouse strain in which a green fluorescent protein (GFP) is driven to be expressed under control of the neuropeptide Y (NPY) promoter, we identified NPY interneurons and compared them with striatal principal neurons. We found that the bacteria artificial chromosome (BAC)-npy mouse expresses GFP with high fidelity in the striatum to the endogenous expression of NPY...
November 2009: Journal of Neurophysiology
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