Hiroki Furuie, Yuka Kimura, Tatsuhiro Akaishi, Misa Yamada, Yoshiki Miyasaka, Akiyoshi Saitoh, Norihiro Shibuya, Akiko Watanabe, Naoki Kusunose, Tomoji Mashimo, Takeo Yoshikawa, Mitsuhiko Yamada, Kazuho Abe, Hideo Kimura
Hydrogen sulfide (H2 S) and polysulfides (H2 Sn , n ≥ 2) are signaling molecules produced by 3-mercaptopyruvate sulfurtransferase (3MST) that play various physiological roles, including the induction of hippocampal long-term potentiation (LTP), a synaptic model of memory formation, by enhancing N-methyl-D-aspartate (NMDA) receptor activity. However, the presynaptic action of H2 S/H2 Sn on neurotransmitter release, regulation of LTP induction, and animal behavior are poorly understood. Here, we showed that H2 S/H2 S2 applied to the rat hippocampus by in vivo microdialysis induces the release of GABA, glutamate, and D-serine, a co-agonist of NMDA receptors...
October 31, 2023: Scientific Reports