keyword
MENU ▼
Read by QxMD icon Read
search

Pgrmc1

keyword
https://www.readbyqxmd.com/read/29778442/developmental-profiles-of-progesterone-receptor-transcripts-and-molecular-responses-to-gestagen-exposure-during-silurana-tropicalis-early-development
#1
Paisley Thomson, Valerie S Langlois
Environmental gestagens are an emerging class of contaminants that have been recently measured in surface water and can interfere with reproduction in aquatic vertebrates. Gestagens include endogenous progestogens, such as progesterone (P4), which bind P4-receptors and have critically important roles in vertebrate physiology and reproduction. Gestagens also include synthetic progestins, which are components of human and veterinary drugs, such as melengestrol acetate (MGA). Endogenous progestogens are essential in the regulation of reproduction in mammalian species, but the role of P4 in amphibian larval development remains unclear...
May 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29674524/insulin-receptor-plasma-membrane-levels-increased-by-the-progesterone-receptor-membrane-component-1
#2
Kaia K Hampton, Hilaree Frazier, Katie Anderson, Olivier Thibault, Rolf J Craven
The Insulin Receptor (IR) is a ligand-activated receptor tyrosine kinase that has a key role in metabolism, cellular survival and proliferation. Progesterone receptor membrane component 1 (PGRMC1) promotes cellular signaling via receptor trafficking, and is essential for some elements of tumor growth and metastasis. In the present study, we demonstrate that PGRMC1 co-precipitates with IR. Furthermore, we show that PGRMC1 increases plasma membrane IR levels in multiple cell lines and decreases insulin binding at the cell surface...
April 19, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29649418/roles-of-progesterone-receptor-membrane-component-1-and-membrane-progestin-receptor-alpha-in-regulation-of-zebrafish-oocyte-maturation
#3
Joseph Aizen, Yefei Pang, Caleb Harris, Aubrey Converse, Yong Zhu, Meagan A Aguirre, Peter Thomas
Although previous studies suggest membrane progesterone receptor alpha (mPRα/Paqr7) mediates 17, 20β-dihydroxy-4-pregnen-3-one (DHP) induction of oocyte maturation (OM) in zebrafish, critical information needed to establish mPRα as the receptor mediating OM, is lacking. The relative potencies of progestins and specific mPRα agonists in inducing OM matched their relative binding affinities for zebrafish mPRα, supporting its role in OM. Microinjection of pertussis toxin blocked DHP induction of OM and the progestin-induced decrease in cyclic AMP levels, suggesting mPRα activates an inhibitory G protein (Gi)...
April 9, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29563759/progesterone-receptor-membrane-component-1-as-a-potential-prognostic-biomarker-for-hepatocellular-carcinoma
#4
Hung-Wen Tsai, Chung-Liang Ho, Shu-Wen Cheng, Yih-Jyh Lin, Chou-Cheng Chen, Pin-Nan Cheng, Chia-Jui Yen, Ting-Tsung Chang, Po-Min Chiang, Shih-Huang Chan, Cheng-Hsun Ho, Shu-Hui Chen, Yi-Wen Wang, Nan-Haw Chow, Jou-Chun Lin
AIM: To investigate the clinicopathological significance of progesterone receptor membrane component 1 (PGRMC1) and PGRMC2 in hepatocellular carcinoma (HCC). METHODS: We performed immunohistochemical staining to evaluate the estrogen receptor (ER), progesterone receptor (PR), PGRMC1, and PGRMC2 in a clinical cohort consisting of 89 paired HCC and non-tumor liver samples. We also analyzed HCC data ( n = 373) from The Cancer Genome Atlas (TCGA). We correlated the expression status of PGRMC1 and PGRMC2 with clinicopathological indicators and the clinical outcomes of the HCC patients...
March 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29491078/expression-of-progesterone-and-androgen-receptors-in-the-breast-of-premenopausal-women-considering-menstrual-phase
#5
Mia Fahlén, Hua Zhang, Lars Löfgren, Britt Masironi, Eva VON Schoultz, B O VON Schoultz, Lena Sahlin
BACKGROUND: Progesterone and androgens are important for normal development and tumorigenesis of the breast. PATIENTS AND METHODS: Breast tissue samples from 49 premenopausal women were obtained. The progesterone receptors (PRA, PRB, PGRMC1 and PGRMC2) and the androgen receptor (AR) were determined in malignant and benign breast tumors and control tissues. RESULTS: The PRB and AR mRNA levels were highest in tumors. PGRMC1 and PGRMC2 mRNA levels were higher in malignant tumors compared to their paired normal tissues...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29490568/the-relationship-of-circular-rnas-with-ovarian-endometriosis
#6
Xiaoxuan Xu, Shuang-Zheng Jia, Yi Dai, Jun-Ji Zhang, Xiaoyan Li, Jinghua Shi, Jinhua Leng, Jinghe Lang
Circular RNAs (circRNAs) are involved in the pathogenesis of many diseases, although their expression pattern and role in endometriosis remains unknown. Therefore, here, we profiled the expression patterns of circRNAs in ovarian ectopic and paired eutopic endometria as well as constructed a circRNA-miRNA-mRNA network. Circular RNA and messenger RNA (mRNA) expression profiles were assessed by a microarray analysis in 4 patients. Quantitative real-time polymerase chain reaction (qRT-PCR) validation of 8 circRNAs and mRNAs was conducted in another 37 patients...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29445107/progesterone-receptor-membrane-component-1-suppresses-the-p53-and-wnt-%C3%AE-catenin-pathways-to-promote-human-pluripotent-stem-cell-self-renewal
#7
Ji Yea Kim, So Young Kim, Hong Seo Choi, Min Kyu Kim, Hyun Min Lee, Young-Joo Jang, Chun Jeih Ryu
Progesterone receptor membrane component 1 (PGRMC1) is a multifunctional heme-binding protein involved in various diseases, including cancers and Alzheimer's disease. Previously, we generated two monoclonal antibodies (MAbs) 108-B6 and 4A68 against surface molecules on human pluripotent stem cells (hPSCs). Here we show that PGRMC1 is the target antigen of both MAbs, and is predominantly expressed on hPSCs and some cancer cells. PGRMC1 is rapidly downregulated during early differentiation of hPSCs. Although PGRMC1 knockdown leads to a spread-out morphology and impaired self-renewal in hPSCs, PGRMC1 knockdown hPSCs do not show apoptosis and autophagy...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29438993/identification-of-progesterone-receptor-membrane-component-1-as-an-interaction-partner-and-possible-regulator-of-fatty-acid-2-hydroxylase
#8
Robert Hardt, Dominic Winter, Volkmar Gieselmann, Matthias Eckhardt
The fatty acid 2-hydroxylase (FA2H) is essential for synthesis of 2-hydroxylated fatty acids in myelinating and other cells, and deficiency of this enzyme causes a complicated form of hereditary spastic paraplegia also known as fatty acid hydroxylase-associated neurodegeneration. Despite its important role in sphingolipid metabolism, regulation of FA2H and its interaction with other proteins involved in the same or other metabolic pathways is poorly understood. To identify potential interaction partners of the enzyme, quantitative mass spectrometry using stable isotope labeling of cells was combined with formaldehyde cross-linking and proximity biotinylation, respectively...
March 6, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29339453/pgrmc1-localization-and-putative-function-in-the-nucleolus-of-bovine-granulosa-cells-and-oocytes
#9
Laura Terzaghi, Alberto Maria Luciano, Priscila C Dall'Acqua, Silvia C Modina, John J Peluso, Valentina Lodde
Progesterone receptor membrane component-1 (PGRMC1) is a highly conserved multifunctional protein that is found in numerous systems, including reproductive system. Interestingly, PGRMC1 is expressed at several intracellular locations, including the nucleolus. The aim of this study is to investigate the functional relationship between PGRMC1 and nucleolus. Immunofluorescence experiments confirmed PGRMC1's nucleolar localization in cultured bovine granulosa cells (bGC) and oocytes. Additional experiments conducted on bGC revealed that PGRMC1 co-localizes with nucleolin (NCL), a major nucleolar protein...
March 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29196065/steroidogenic-enzymes-their-products-and-sex-steroid-receptors-during-testis-development-and-spermatogenesis-in-the-domestic-cat-felis-catus
#10
Beate C Braun, Minami W Okuyama, Karin Müller, Martin Dehnhard, Katarina Jewgenow
In the present study we comprehensively characterize intratesticular sex steroid production, metabolism and receptors in the domestic cat to elucidate the role of testosterone, estradiol and progesterone in testis development, steroid synthesis and spermatogenesis. There is a great demand for new concepts of fertility control in domestic (feral) cats and wild felids. The acquired knowledge will help to understand the regulation of spermatogenesis in felids, and may reveal new target points for male contraception...
April 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29179606/membrane-initiated-effects-of-serelys-%C3%A2-on-proliferation-and-apoptosis-of-human-breast-cancer-cells
#11
Harald Seeger, Xiangyan Ruan, Hans Neubauer, Sara Brucker, Alfred O Mueck
Herbal extracts used for the alleviation of postmenopausal symptoms might have a lower risk of breast cancer development than hormone therapy. Serelys® is a product composed of purified pollen cytoplasm extracts. Recent experimental data revealed that estrogens might trigger a further proliferative effect on breast cancer cells via the progesterone receptor membrane component-1 (PGRMC1) in addition to the proliferative effect via intracellularly located receptors. MCF-7 and T47D cells were stably transfected with PGRMC1...
November 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29102625/reprint-of-role-of-g-protein-coupled-estrogen-receptor-gper-gpr30-in-maintenance-of-meiotic-arrest-in-fish-oocytes
#12
REVIEW
Peter Thomas
An essential role for GPER (formerly known as GPR30) in regulating mammalian reproduction has not been identified to date, although it has shown to be involved in the regulation a broad range of other estrogen-dependent functions. In contrast, an important reproductive role for GPER in the maintenance of oocyte meiotic arrest has been identified in teleost fishes, which is briefly reviewed here. Recent studies have clearly shown that ovarian follicle production of estradiol-17β (E2 ) maintains meiotic arrest in several teleost species through activation of GPER coupled to a stimulatory G protein (Gs ) on oocyte plasma membranes, resulting in stimulation of cAMP production and maintenance of elevated cAMP levels...
February 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29072679/anp-promotes-proliferation-and-inhibits-apoptosis-of-ovarian-granulosa-cells-by-npra-pgrmc1-egfr-complex-and-improves-ovary-functions-of-pcos-rats
#13
Qin Zheng, Yulin Li, Dandan Zhang, Xinyuan Cui, Kuixing Dai, Yu Yang, Shuai Liu, Jichun Tan, Qiu Yan
Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by polycystic ovaries, hyperandrogenism and anovulation. It is one of the main causes of infertility. RU486 is an antagonist of progesterone receptor, and most commonly used as a contraceptive. However, whether RU486 is correlated with PCOS remains unclear. Atrial natriuretic peptide (ANP) is a small peptide with natriuretic and diuretic functions, and its availability to be used in PCOS treatment is unknown. Here, we showed that the serum ANP level was lower in PCOS patients than that in healthy women, and it was also decreased in the serum and ovarian tissues of RU486-induced PCOS rats compared with the control rats...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29069804/progesterone-receptor-membrane-component-1-is-phosphorylated-upon-progestin-treatment-in-breast-cancer-cells
#14
Marina Willibald, Giuliano Bayer, Vanessa Stahlhut, Gereon Poschmann, Kai Stühler, Berthold Gierke, Michael Pawlak, Harald Seeger, Alfred O Mueck, Dieter Niederacher, Tanja Fehm, Hans Neubauer
Menopausal hormone therapy, using estrogen and synthetic progestins, is associated with an increased risk of developing breast cancer. The effect of progestins on breast cells is complex and not yet fully understood. In previous in vitro and in vivo studies, we found different progestins to increase the proliferation of Progesterone Receptor Membrane Component-1 (PGRMC1)-overexpressing MCF7 cells (MCF7/PGRMC1), suggesting a possible role of PGRMC1 in transducing membrane-initiated progestin signals. Understanding the activation mechanism of PGRMC1 by progestins will provide deeper insights into the mode of action of progestins on breast cells and the often-reported phenomenon of elevated breast cancer rates upon progestin-based hormone therapy...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050215/proteomics-analysis-of-bladder-cancer-invasion-targeting-eif3d-for-therapeutic-intervention
#15
Agnieszka Latosinska, Marika Mokou, Manousos Makridakis, William Mullen, Jerome Zoidakis, Vasiliki Lygirou, Maria Frantzi, Ioannis Katafigiotis, Konstantinos Stravodimos, Marie C Hupe, Maciej Dobrzynski, Walter Kolch, Axel S Merseburger, Harald Mischak, Maria G Roubelakis, Antonia Vlahou
Patients with advanced bladder cancer have poor outcomes, indicating a need for more efficient therapeutic approaches. This study characterizes proteomic changes underlying bladder cancer invasion aiming for the better understanding of disease pathophysiology and identification of drug targets. High resolution liquid chromatography coupled to tandem mass spectrometry analysis of tissue specimens from patients with non-muscle invasive (NMIBC, stage pTa) and muscle invasive bladder cancer (MIBC, stages pT2+) was conducted...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28962850/expression-of-membrane-progesterone-receptors-mprs-in-rat-peripheral-glial-cell-membranes-and-their-potential-role-in-the-modulation-of-cell-migration-and-protein-expression
#16
Luca F Castelnovo, Valerio Magnaghi, Peter Thomas
The role played by progestogens in modulating Schwann cell pathophysiology is well established. Progestogens exert their effects in these cells through both classical genomic and non-genomic mechanisms, the latter mediated by the GABA-A receptor. However, there is evidence that other receptors may be involved. Membrane progesterone receptors (mPRs) are novel 7-transmembrane receptors coupled to G proteins that have been characterized in different tissues and cells, including the central nervous system (CNS)...
September 26, 2017: Steroids
https://www.readbyqxmd.com/read/28911927/dynamic-expression-of-pgrmc1-and-serbp1-in-human-endometrium-an-implication-in-the-human-decidualization-process
#17
Stefania Salsano, Alicia Quiñonero, Silvia Pérez, Tamara Garrido Gómez, Carlos Simón, Francisco Dominguez
OBJECTIVE: To characterize PGRMC1 and SERBP1 in human endometrium and to investigate the putative role of PGRMC1 in endometrial decidualization. DESIGN: The PGRMC1 and SERBP1 expression in human endometrium was determined throughout the menstrual cycle. We analyzed the colocalization of PGRMC1 and SERBP1. Then, endometrial stromal cells (ESCs) were isolated to investigate the functional effect of PGRMC1 overexpression on decidualization. SETTING: IVI clinic...
November 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28701017/high-level-of-progesteron-receptor-membrane-component-1-pgrmc-1-in-tissue-of-breast-cancer-patients-is-associated-with-worse-response-to-anthracycline-based-neoadjuvant-therapy
#18
Marina Willibald, Isabel Wurster, Christoph Meisner, Ulrich Vogel, Harald Seeger, Alfred O Mueck, Tanja Fehm, Hans Neubauer
PGRMC1 is known to be highly expressed in breast cancer tissue and is associated with chemoresistance in breast cancer cells. However, its role in breast cancer signaling is not fully understood yet. In the present study, the expression status of PGRMC1 and its phosphorylated version (pPGRMC1) in breast cancer tissue and surrounding stroma before and after neoadjuvant therapy was examined to find a possible association to therapy response. Tissue biopsies of 69 breast cancer patients were analyzed by immunohistochemistry for expression levels of PGRMC1 and pPGRMC1...
August 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28610679/the-presence-of-a-membrane-bound-progesterone-receptor-induces-growth-of-breast-cancer-with-norethisterone-but-not-with-progesterone-a-xenograft-model
#19
Yue Zhao, Xiangyan Ruan, Husheng Wang, Xue Li, Muqing Gu, Lijuan Wang, Yanglu Li, Harald Seeger, Alfred O Mueck
OBJECTIVES: During menopausal hormone therapy (MHT) a possible increase in breast cancer risk is thought to depend mainly on the progestogen component. In vitro studies have shown that the progesterone receptor membrane component 1 (PGRMC1) is important for tumor proliferation induced by progestogens. The primary aim of this study was to compare for the first time the natural progestogen, progesterone (P), with a synthetic progestogen, norethisterone (NET), using a xenograft model. METHODS: MCF7 cells, transfected with PGRMC1 plasmid or empty vector, were injected into nude mice and estradiol (E2) pellets were implanted...
August 2017: Maturitas
https://www.readbyqxmd.com/read/28493650/pro-survival-redox-signalling-in-progesterone-mediated-retinal-neuroprotection
#20
Ana M Ruiz Lopez, Sarah L Roche, Alice C Wyse Jackson, Jennifer N Moloney, Ashleigh M Byrne, Thomas G Cotter
Retinitis pigmentosa (RP) is a group of hereditary retinal diseases, characterised by photoreceptor cell loss. Despite a substantial understanding of the mechanisms leading to cell death, an effective therapeutic strategy is sought. Our laboratory has previously demonstrated the neuroprotective properties of Norgestrel, a progesterone analogue, in the degenerating retina, mediated in part by the neurotrophic factor basic fibroblast growth factor (bFGF). In other retinal studies, we have also presented a pro-survival role for reactive oxygen species (ROS), downstream of bFGF...
May 11, 2017: European Journal of Neuroscience
keyword
keyword
102561
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"