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https://www.readbyqxmd.com/read/27926996/small-molecule-modulator-of-sigma-2-receptor-is-neuroprotective-and-reduces-cognitive-deficits-and-neuro-inflammation-in-experimental-models-of-alzheimer-s-disease
#1
Bitna Yi, James J Sahn, Pooneh Memar Ardestani, Andrew K Evans, Luisa Scott, Jessica Z Chan, Sangeetha Iyer, Ashley Crisp, Gabriella Zuniga, Jonathan Pierce-Shimomura, Stephen F Martin, Mehrdad Shamloo
Accumulating evidence suggests that modulating the sigma 2 receptor (Sig2R) can provide beneficial effects for neurodegenerative diseases. Herein, we report the identification of a novel class of Sig2R binding ligands and their cellular and in vivo activity in experimental models of Alzheimer's disease (AD). We report that SAS-0132 and DKR-1051, selective ligands of Sig2R, modulate intracellular Ca(2+) levels in human SK-N-SH neuroblastoma cells. The Sig2R antagonists SAS-0132 and JVW-1009 are neuroprotective in a C...
December 7, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27859822/expression-of-steroidogenic-enzymes-and-steroid-receptors-in-foetal-gonads-of-domestic-cat-sex-similarities-and-differences
#2
B C Braun, K Jewgenow
Foetal gonads already produce steroid hormones and by this influence the further development of external and internal genitalia as well as of the brain. Beside this, foetal gonads themselves can be influenced by foetal or maternal hormones. The time course of foetal gonadal development can differ between species. As knowledge on processes in domestic cats is very limited, the steroidogenic enzyme expressions as well as these of steroid receptors were analysed in foetal gonads of domestic cats. We investigated a period from beginning of the second half of pregnancy to the beginning of the third trimester; a phase, where also gonadal development proceeds...
November 15, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27848973/progesterone-receptor-membrane-component-1-mediates-progesterone-induced-suppression-of-oocyte-meiotic-prophase-i-and-primordial-folliculogenesis
#3
Meng Guo, Cheng Zhang, Yan Wang, Lizhao Feng, Zhengpin Wang, Wanbo Niu, Xiaoyan Du, Wang Tang, Yuna Li, Chao Wang, Zhenwen Chen
Well-timed progression of primordial folliculogenesis is essential for mammalian female fertility. Progesterone (P4) inhibits primordial follicle formation under physiological conditions; however, P4 receptor that mediates this effect and its underlying mechanisms are unclear. In this study, we used an in vitro organ culture system to show that progesterone receptor membrane component 1 (PGRMC1) mediated P4-induced inhibition of oocyte meiotic prophase I and primordial follicle formation. We found that membrane-impermeable BSA-conjugated P4 inhibited primordial follicle formation similar to that by P4...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27846214/proteomic-profiling-for-identification-of-novel-biomarkers-differentially-expressed-in-human-ovaries-from-polycystic-ovary-syndrome-patients
#4
Li Li, Jiangyu Zhang, Qingshan Deng, Jieming Li, Zhengfen Li, Yao Xiao, Shuiwang Hu, Tiantian Li, Qiuxiao Tan, Xiaofang Li, Bingshu Luo, Hui Mo
OBJECTIVES: To identify differential protein expression pattern associated with polycystic ovary syndrome (PCOS). METHODS: Twenty women were recruited for the study, ten with PCOS as a test group and ten without PCOS as a control group. Differential in-gel electrophoresis (DIGE) analysis and mass spectroscopy were employed to identify proteins that were differentially expressed between the PCOS and normal ovaries. The differentially expressed proteins were further validated by western blot (WB) and immunohistochemistry (IHC)...
2016: PloS One
https://www.readbyqxmd.com/read/27763693/progesterone-analogue-protects-stressed-photoreceptors-via-bfgf-mediated-calcium-influx
#5
Alice C Wyse-Jackson, Sarah L Roche, Ana M Ruiz-Lopez, Jennifer N Moloney, Ashleigh M Byrne, Thomas G Cotter
Retinitis pigmentosa (RP) is a degenerative retinal disease leading to photoreceptor cell loss. In 2011, our group identified the synthetic progesterone 'Norgestrel' as a potential treatment for RP. Subsequent research showed Norgestrel to work through progesterone receptor membrane component 1 (PGRMC1) activation and upregulation of neuroprotective basic fibroblast growth factor (bFGF). Using trophic factor deprivation of 661W photoreceptor-like cells, we aimed to further elucidate the mechanism leading to Norgestrel-induced neuroprotection...
October 20, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27749742/increased-expression-of-progesterone-receptor-membrane-component-1-is-associated-with-aggressive-phenotype-and-poor-prognosis-in-er-positive-and-negative-breast-cancer
#6
Xiangyan Ruan, Ying Zhang, Alfred O Mueck, Marina Willibald, Harald Seeger, Tanja Fehm, Sara Brucker, Hans Neubauer
OBJECTIVE: Expression of progesterone receptor membrane component 1 (PGRMC1) has been shown to be higher in breast cancer than normal tissue. We have previously shown that certain progestogens strongly stimulate proliferation of breast cancer cells overexpressing PGRMC1, and therefore hypothesize that PGRMC1 may play a critical role in breast cancer progression. Because little information is available if expression of PGRMC1 is also associated with worse prognosis for breast cancer patients, in this study we investigated the clinicopathologic significance of PGRMC1 expression in breast cancer tissue...
October 3, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27641676/progesterone-estrogen-and-androgen-receptors-in-the-corpus-luteum-of-the-domestic-cat-iberian-lynx-lynx-pardinus-and-eurasian-lynx-lynx-lynx
#7
Olga Amelkina, Lina Zschockelt, Johanna Painer, Rodrigo Serra, Francisco Villaespesa, Eberhard Krause, Katarina Jewgenow, Beate C Braun
In contrast to the species studied, the corpus luteum (CL) of Iberian and Eurasian lynx physiologically persists in the ovary for more than 2 years and continues to secrete progesterone. Such persistent CL (perCL) transition into the next cycle and are present in the ovary together with the freshly formed CL (frCL) of a new ovulation. To date, the mechanisms supporting such CL persistence are not known. We analyzed the potential receptivity of feline CL to sex steroids through mRNA measurements of progesterone receptor (PGR), progesterone receptor membrane components (PGRMC) 1 and 2, estrogen receptor (ESR) 1 and ESR2, G protein-coupled estrogen receptor 1 (GPER1), and androgen receptor (AR)...
July 5, 2016: Theriogenology
https://www.readbyqxmd.com/read/27599036/a-novel-role-for-progesterone-receptor-membrane-component-1-pgrmc1-a-partner-and-regulator-of-ferrochelatase
#8
Robert B Piel, Mesafint T Shiferaw, Ajay A Vashisht, Jason R Marcero, Jeremy L Praissman, John D Phillips, James A Wohlschlegel, Amy E Medlock
Heme is an iron-containing cofactor essential for multiple cellular processes and fundamental activities such as oxygen transport. To better understand the means by which heme synthesis is regulated during erythropoiesis, affinity purification coupled with mass spectrometry (MS) was performed to identify putative protein partners interacting with ferrochelatase (FECH), the terminal enzyme in the heme biosynthetic pathway. Both progesterone receptor membrane component 1 (PGRMC1) and progesterone receptor membrane component 2 (PGRMC2) were identified in these experiments...
September 20, 2016: Biochemistry
https://www.readbyqxmd.com/read/27587714/pgrmc1-a-fertility-stabilizer
#9
Katie Gerhardt
No abstract text is available yet for this article.
September 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27565814/cystathionine-%C3%AE-synthase-and-pgrmc1-as-co-sensors
#10
Yasuaki Kabe, Takehiro Yamamoto, Mayumi Kajimura, Yuki Sugiura, Ikko Koike, Mitsuyo Ohmura, Takashi Nakamura, Yasuhito Tokumoto, Hitoshi Tsugawa, Hiroshi Handa, Takuya Kobayashi, Makoto Suematsu
Heme oxygenase (HO) is a mono-oxygenase utilizing heme and molecular oxygen (O2) as substrates to generate biliverdin-IXα and carbon monoxide (CO). HO-1 is inducible under stress conditions, while HO-2 is constitutive. A balance between heme and CO was shown to regulate cell death and survival in many experimental models. However, direct molecular targets to which CO binds to regulate cellular functions remained to be fully examined. We have revealed novel roles of CO-responsive proteins, cystathionine β-synthase (CBS) and progesterone receptor membrane component 1 (PGRMC1), in regulating cellular functions...
August 24, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27452206/the-emerging-role-of-progesterone-receptor-membrane-component-1-pgrmc1-in-cancer-biology
#11
REVIEW
Michael A Cahill, Jalal A Jazayeri, Susan M Catalano, Shinya Toyokuni, Zaklina Kovacevic, Des R Richardson
Progesterone receptor membrane component 1 (PGRMC1) is a multi-functional protein with a heme-binding moiety related to that of cytochrome b5, which is a putative progesterone receptor. The recently solved PGRMC1 structure revealed that heme-binding involves coordination by a tyrosinate ion at Y113, and induces dimerization which is stabilized by hydrophobic stacking of heme on adjacent monomers. Dimerization is required for association with cytochrome P450 (cyP450) enzymes, which mediates chemoresistance to doxorubicin and may be responsible for PGRMC1's anti-apoptotic activity...
July 22, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27448967/pgrmc1-regulation-by-phosphorylation-potential-new-insights-in-controlling-biological-activity
#12
Michael A Cahill, Jalal A Jazayeri, Zaklina Kovacevic, Des R Richardson
Progesterone receptor membrane component 1 (PGRMC1) is a multifunctional protein implicated in multiple pathologies, including cancer and Alzheimer's disease. The recently published structure of PGRMC1 revealed heme-mediated dimerization that directed the PGRMC1-dependent cytochrome P450-mediated detoxification of doxorubicin. We describe here how the PGRMC1 structure also enables important new insights into the possible regulation of PGRMC1 function by phosphorylation. Predicted regulatory interaction sites for SH2- and SH3-domain proteins are in non-structured regions that could be available to cytoplasmic enzymes...
July 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27376101/identification-of-the-sigma-2-receptor-distinct-from-the-progesterone-receptor-membrane-component-1-pgrmc1
#13
Takato Hiranita
No abstract text is available yet for this article.
2016: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/27355272/pgrmc1-and-the-faithful-progression-through-mitosis-and-meiosis
#14
Alberto M Luciano, John J Peluso
No abstract text is available yet for this article.
September 2016: Cell Cycle
https://www.readbyqxmd.com/read/27349565/progestin-mediated-activation-of-mapk-and-akt-in-nuclear-progesterone-receptor-negative-breast-epithelial-cells-the-role-of-membrane-progesterone-receptors
#15
Monica Salazar, Alejandra Lerma-Ortiz, Grace M Hooks, Amanda K Ashley, Ryan L Ashley
Progesterone (P4), a steroid produced during estrous cycles and gestation for maintenance of pregnancy, also plays key roles in breast development to allow lactation post-parturition. Progestins (P4 and related steroids) are also implicated in breast cancer etiology. Hormone replacement therapy containing both estrogen and progestins increases breast cancer incidence while estrogen hormone therapy lowers breast cancer risk. P4 signaling via nuclear P4 receptors (PRs) has been extensively studied in breast cancer, however, progestin signaling via non-classical membrane bound progestin receptors (MPRs and PGRMC1) remains unclear...
October 10, 2016: Gene
https://www.readbyqxmd.com/read/27340667/expression-of-progesterone-receptor-membrane-component-1-pgrmc1-progestin-and-adipoq-receptor-7-paqpr7-and-plasminogen-activator-inhibitor-1-rna-binding-protein-pairbp1-in-glioma-spheroids-in-vitro
#16
Juraj Hlavaty, Reinhard Ertl, Ingrid Miller, Cordula Gabriel
Objective. Some effects of progesterone on glioma cells can be explained through the slow, genomic mediated response via nuclear receptors; the other effects suggest potential role of a fast, nongenomic action mediated by membrane-associated progesterone receptors. Methods. The effects of progesterone treatment on the expression levels of progesterone receptor membrane component 1 (PGRMC1), plasminogen activator inhibitor 1 RNA-binding protein (PAIRBP1), and progestin and adipoQ receptor 7 (PAQR7) on both mRNA and protein levels were investigated in spheroids derived from human glioma cell lines U-87 MG and LN-229...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27309940/conditional-ablation-of-progesterone-receptor-membrane-component-1-results-in-subfertility-in-the-female-and-development-of-endometrial-cysts
#17
Melissa L McCallum, Cindy A Pru, Yuichi Niikura, Siu-Pok Yee, John P Lydon, John J Peluso, James K Pru
Progesterone (P4) is essential for female fertility. The objective of this study was to evaluate the functional requirement of the nonclassical P4 receptor (PGR), PGR membrane component 1, in regulating female fertility. To achieve this goal, the Pgrmc1 gene was floxed by insertion of loxP sites on each side of exon 2. Pgrmc1 floxed (Pgrmc1(fl/fl)) mice were crossed with Pgr(cre) or Amhr2(cre) mice to delete Pgrmc1 (Pgrmc1(d/d)) from the female reproductive tract. A 6-month breeding trial revealed that conditional ablation of Pgrmc1 with Pgr(cre/+) mice resulted in a 40% reduction (P = ...
September 2016: Endocrinology
https://www.readbyqxmd.com/read/27260975/pgrmc1-participates-in-late-events-of-bovine-granulosa-cells-mitosis-and-oocyte-meiosis
#18
L Terzaghi, I Tessaro, F Raucci, V Merico, G Mazzini, S Garagna, M Zuccotti, F Franciosi, V Lodde
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in both oocyte and ovarian somatic cells, where it is found in multiple cellular sub-compartments including the mitotic spindle apparatus. PGRMC1 localization in the maturing bovine oocytes mirrors its localization in mitotic cells, suggesting a possible common action in mitosis and meiosis. To test the hypothesis that altering PGRMC1 activity leads to similar defects in mitosis and meiosis, PGRMC1 function was perturbed in cultured bovine granulosa cells (bGC) and maturing oocytes and the effect on mitotic and meiotic progression assessed...
August 2, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27018395/cloning-and-olfactory-expression-of-progestin-receptors-in-the-chinese-black-sleeper-bostrichthys-sinensis
#19
Yu Ting Zhang, Dong Teng Liu, Yong Zhu, Shi Xi Chen, Wan Shu Hong
Our previous studies suggested that 17α,20β-dihydroxy-4-pregnen-3-one (DHP), an oocyte maturation inducing progestin, also acts as a sex pheromone in Chinese black sleeper Bostrichthys sinensis, a fish species that inhabits intertidal zones and mates and spawns inside a muddy burrow. The electro-olfactogram response to DHP increased during the breeding season. In the present study, we cloned the cDNAs of the nine progestin receptors (pgr, paqr5, 6, 7(a, b), 8, 9, pgrmc1, 2) from B. sinensis, analyzed their tissue distribution, and determined the expression in the olfactory rosette during the reproductive cycle in female and male fish...
May 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27008165/the-effects-of-chronic-lifelong-activation-of-the-ahr-pathway-by-industrial-chemical-pollutants-on-female-human-reproduction
#20
Aldo Cavallini, Catia Lippolis, Margherita Vacca, Claudia Nardelli, Alessandra Castegna, Fabio Arnesano, Nicola Carella, Raffaella Depalo
Environmental chemicals, such as heavy metals, affect female reproductive function. A biological sensor of the signals of many toxic chemical compounds seems to be the aryl hydrocarbon receptor (AHR). Previous studies demonstrated the environmental of heavy metals in Taranto city (Italy), an area that has been influenced by anthropogenic factors such as industrial activities and waste treatments since 1986. However, the impact of these elements on female fertility in this geographic area has never been analyzed...
2016: PloS One
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