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Spectral mammography

Eva M Fallenberg, Florian F Schmitzberger, Heba Amer, Barbara Ingold-Heppner, Corinne Balleyguier, Felix Diekmann, Florian Engelken, Ritse M Mann, Diane M Renz, Ulrich Bick, Bernd Hamm, Clarisse Dromain
OBJECTIVES: To compare the diagnostic performance of contrast-enhanced spectral mammography (CESM) to digital mammography (MG) and magnetic resonance imaging (MRI) in a prospective two-centre, multi-reader study. METHODS: One hundred seventy-eight women (mean age 53 years) with invasive breast cancer and/or DCIS were included after ethics board approval. MG, CESM and CESM + MG were evaluated by three blinded radiologists based on amended ACR BI-RADS criteria...
November 28, 2016: European Radiology
Francesco Sardanelli, Eva M Fallenberg, Paola Clauser, Rubina M Trimboli, Julia Camps-Herrero, Thomas H Helbich, Gabor Forrai
: This article summarises the information to be offered to women about mammography. After a delineation of the aim of early diagnosis of breast cancer, the difference between screening mammography and diagnostic mammography is explained. The need to bring images and reports from the previous mammogram (and from other recent breast imaging examinations) is highlighted. Mammography technique and procedure are described with particular attention to discomfort and pain experienced by a small number of women who undergo the test...
November 16, 2016: Insights Into Imaging
Huanjun Ding, David Sennung, Hyo-Min Cho, Sabee Molloi
PURPOSE: The positive predictive power for malignancy can potentially be improved, if the chemical compositions of suspicious breast lesions can be reliably measured in screening mammography. The purpose of this study is to investigate the feasibility of quantifying breast lesion composition, in terms of water and lipid contents, with spectral mammography. METHODS: Phantom and tissue samples were imaged with a spectral mammography system based on silicon-strip photon-counting detectors...
October 2016: Medical Physics
Chandni Bhimani, Danielle Matta, Robyn G Roth, Lydia Liao, Elizabeth Tinney, Kristin Brill, Pauline Germaine
RATIONALE AND OBJECTIVES: Contrast-enhanced spectral mammography (CESM) combines the benefits of full field digital mammography with the concept of tumor angiogenesis. Technique and practical applications of CESM are discussed. MATERIALS AND METHODS: An overview of the technique is followed by a demonstration of practical applications of CESM in our practice. RESULTS: We have successfully implemented CESM into our practice as a screening, diagnostic, staging, and treatment response tool...
October 20, 2016: Academic Radiology
Elżbieta Łuczyńska, Joanna Niemiec, Edward Hendrick, Sylwia Heinze, Janusz Jaszczyński, Jerzy Jakubowicz, Beata Sas-Korczyńska, Janusz Rys
BACKGROUND Contrast enhanced spectral mammography (CESM) is a new method of breast cancer diagnosis in which an iodinated contrast agent is injected and dual-energy mammography is obtained in multiple views of the breasts. The aim of this study was to compare the degree of enhancement on CESM with lesion characteristics on mammography (MG) and lesion histology in women with suspicious breast lesions. MATERIAL AND METHODS The degree of enhancement on CESM (absent, weak, medium, or strong) was compared to lesion characteristics on MG (mass, mass with microcalcifications, or microcalcifications alone) and histology (infiltrating carcinoma, intraductal carcinoma, or benign) to compare sensitivity of the two modalities and to establish correlations that might improve diagnostic accuracy...
October 21, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Chandni Bhimani, Luna Li, Lydia Liao, Robyn G Roth, Elizabeth Tinney, Pauline Germaine
RATIONALE AND OBJECTIVES: Contrast-enhanced spectral mammography (CESM) uses full field digital mammography with the added benefit of intravenous contrast administration to significantly reduce false-positive and false-negative results and improve specificity while maintaining high sensitivity. For CESM to fulfill its purpose, one should be aware of possible artifacts and other factors which may interfere with image quality, and attention should be taken to minimize these factors. MATERIALS AND METHODS: This pictorial demonstration will depict types of artifacts detected and other factors that interfere with image acquisition in our practice since CESM implementation...
October 17, 2016: Academic Radiology
L Li, R Roth, P Germaine, S Ren, M Lee, K Hunter, E Tinney, L Liao
OBJECTIVE: The purpose of this study was to retrospectively compare the diagnostic performance of contrast-enhanced spectral mammography (CESM) with that of breast magnetic resonance imaging (BMRI) in breast cancer detection using parameters, including sensitivity, positive predictive value (PPV), lesion size, morphology, lesion and background enhancement, and examination time. MATERIALS AND METHODS: A total of 48 women (mean age, 56years±10.6 [SD]) with breast lesions detected between October 2012 and March 2014 were included...
September 26, 2016: Diagnostic and Interventional Imaging
Yun-Chung Cheung, Yu-Hsiang Juan, Yu-Ching Lin, Yung-Feng Lo, Hsiu-Pei Tsai, Shir-Hwa Ueng, Shin-Cheh Chen
BACKGROUND: Mammography screening is a cost-efficient modality with high sensitivity for detecting impalpable cancer with microcalcifications, and results in reduced mortality rates. However, the probability of finding microcalcifications without associated cancerous masses varies. We retrospectively evaluated the diagnosis and cancer probability of the non-mass screened microcalcifications by dual-energy contrast-enhanced spectral mammography (DE-CESM). PATIENTS AND METHODS: With ethical approval from our hospital, we enrolled the cases of DE-CESM for analysis under the following inclusion criteria: (1) referrals due to screened BI-RADS 4 microcalcifications; (2) having DE-CESM prior to stereotactic biopsy; (3) no associated mass found by sonography and physical examination; and (4) pathology-based diagnosis using stereotactic vacuum-assisted breast biopsy...
2016: PloS One
M Funke
Advances in imaging of the female breast have substantially influenced the diagnosis and probably also the therapy and prognosis of breast cancer in the past few years. This article gives an overview of the most important imaging modalities in the diagnosis of breast cancer. Digital mammography is considered to be the gold standard for the early detection of breast cancer. Digital breast tomosynthesis can increase the diagnostic accuracy of mammography and is used for the assessment of equivocal or suspicious mammography findings...
October 2016: Der Radiologe
Elzbieta Luczyńska, Sylwia Heinze, Agnieszka Adamczyk, Janusz Rys, Jerzy W Mitus, Edward Hendrick
Mammography (MG) is the gold-standard in breast cancer detection - the only method documented to reduce breast cancer mortality. Breast ultrasound (US) has been shown to increase sensitivity to breast cancers in screening women with dense breasts. Contrast-enhanced spectral mammography (CESM) is a novel technique intensively developed in the last few years. The goal of this study was to compare the sensitivity, specificity and accuracy of MG, US and CESM in detecting malignant breast lesions. The study included 116 patients...
August 2016: Anticancer Research
Haesung Yoon, Dahye Yoon, Mijin Yun, Ji Soo Choi, Vivian Youngjean Park, Eun-Kyung Kim, Joon Jeong, Ja Seung Koo, Jung Hyun Yoon, Hee Jung Moon, Suhkmann Kim, Min Jung Kim
PURPOSE: Our goal in this study was to find correlations between breast cancer metabolites and conventional quantitative imaging parameters using high-resolution magic angle spinning (HR-MAS) magnetic resonance spectroscopy (MRS) and to find breast cancer subgroups that show high correlations between metabolites and imaging parameters. MATERIALS AND METHODS: Between August 2010 and December 2013, we included 53 female patients (mean age 49.6 years; age range 32-75 years) with a total of 53 breast lesions assessed by the Breast Imaging Reporting and Data System...
2016: PloS One
Alexandra Tsigginou, Christina Gkali, Athanasios Chalazonitis, Eleni Feida, Dimitrios Efthymios Vlachos, Flora Zagouri, Ioannis Rellias, Constantine Dimitrakakis
OBJECTIVE: Despite advancements in technology, mammography remains the golden standard in breast cancer diagnosis and in mortality reduction. Overtime, digital mammography combined with other imaging modalities supported a trend to more accurately presume pathological diagnosis. Dual-energy Contrast Enhanced Spectral Mammography (CESM) represents a relatively new diagnostic tool adjunct to mammography. The aim of this study is to strengthen the BIRADS classification score in order to improve early breast cancer diagnosis...
July 25, 2016: British Journal of Radiology
Qingguo Wang, Kangan Li, Lihui Wang, Jianbing Zhang, Zhiguo Zhou, Yan Feng
PURPOSE: To evaluate diagnostic performances of CESM for breast diseases with comparison to breast MRI in China. MATERIALS AND METHODS: Sixty-eight patients with 77 breast lesions underwent MR and CESM. Two radiologists interpreted either MRI or CESM images, separately and independently. BI-RADS 1-3 and BI-RADS 4-5 were classified into the suspicious benign and suspicious malignant groups. Diagnostic accuracy parameters were calculated. Receiver operating characteristic (ROC) curves were constructed for the two modalities...
2016: SpringerPlus
Julie Sogani, Elizabeth A Morris, Jennifer B Kaplan, Donna D'Alessio, Debra Goldman, Chaya S Moskowitz, Maxine S Jochelson
Purpose To assess the extent of background parenchymal enhancement (BPE) at contrast material-enhanced (CE) spectral mammography and breast magnetic resonance (MR) imaging, to evaluate interreader agreement in BPE assessment, and to examine the relationships between clinical factors and BPE. Materials and Methods This was a retrospective, institutional review board-approved, HIPAA-compliant study. Two hundred seventy-eight women from 25 to 76 years of age with increased breast cancer risk who underwent CE spectral mammography and MR imaging for screening or staging from 2010 through 2014 were included...
July 4, 2016: Radiology
Anne-Marie Tardivel, Corinne Balleyguier, Ariane Dunant, Suzette Delaloge, Chafika Mazouni, Marie-Christine Mathieu, Clarisse Dromain
To assess the value on diagnostic and treatment management of contrast-enhanced spectral mammography (CESM), as adjunct to mammography (MG) and ultrasound (US) in postscreening in a breast cancer unit for patients with newly diagnosed breast cancer or with suspicious findings on conventional imaging. Retrospective review of routine use of bilateral CESM performed between September 2012 and September 2013 in 195 women with suspicious or undetermined findings on MG and/or US. CESM images were blindly reviewed by two radiologists for BI-RADS(®) assessment and probability of malignancy...
September 2016: Breast Journal
Rasha M Kamal, Maha H Helal, Sahar Mansour, Marwa A Haggag, Omniya M Nada, Iman G Farahat, Nelly H Alieldin
OBJECTIVE: to assess the feasibility of using the MRI BI-RADS lexicon morphology descriptors to characterize enhancing breast lesions identified on CESM. PATIENT AND METHODS: The study is a retrospective analysis of the morphology descriptors of 261enhancing breast lesions identified on CESM in 239 patients. We presented morphological categorization of the included lesions into focus, mass and non-mass. Further classifications included 1) multiplicity for "focus" category, 2) shape, margin and internal enhancement for "mass" category and 3) distribution and internal enhancement for "non-mass" category...
June 21, 2016: British Journal of Radiology
S L Tennant, J J James, E J Cornford, Y Chen, H C Burrell, L J Hamilton, C Girio-Fragkoulakis
AIM: To assess the diagnostic accuracy of contrast-enhanced spectral mammography (CESM), and gauge its "added value" in the symptomatic setting. MATERIALS AND METHODS: A retrospective multi-reader review of 100 consecutive CESM examinations was performed. Anonymised low-energy (LE) images were reviewed and given a score for malignancy. At least 3 weeks later, the entire examination (LE and recombined images) was reviewed. Histopathology data were obtained for all cases...
November 2016: Clinical Radiology
Alberto Stefano Tagliafico, Bianca Bignotti, Federica Rossi, Alessio Signori, Maria Pia Sormani, Francesca Valdora, Massimo Calabrese, Nehmat Houssami
PURPOSE: To estimate sensitivity and specificity of CESM for breast cancer diagnosis. METHODS: Systematic review and meta-analysis of the accuracy of CESM in finding breast cancer in highly selected women. We estimated summary receiver operating characteristic curves, sensitivity and specificity according to quality criteria with QUADAS-2. RESULTS: Six hundred four studies were retrieved, 8 of these reporting on 920 patients with 994 lesions, were eligible for inclusion...
August 2016: Breast: Official Journal of the European Society of Mastology
Jeffrey S Nelson, Jered R Wells, Jay A Baker, Ehsan Samei
PURPOSE: The FDA approved the use of digital breast tomosynthesis (DBT) in 2011 as an adjunct to 2D full field digital mammography (FFDM) with the constraint that all DBT acquisitions must be paired with a 2D image to assure adequate interpretative information is provided. Recently manufacturers have developed methods to provide a synthesized 2D image generated from the DBT data with the hope of sparing patients the radiation exposure from the FFDM acquisition. While this much needed alternative effectively reduces the total radiation burden, differences in image quality must also be considered...
May 2016: Medical Physics
U C Lalji, I P L Houben, R Prevos, S Gommers, M van Goethem, S Vanwetswinkel, R Pijnappel, R Steeman, C Frotscher, W Mok, P Nelemans, M L Smidt, R G Beets-Tan, J E Wildberger, M B I Lobbes
OBJECTIVES: Contrast-enhanced spectral mammography (CESM) is a promising problem-solving tool in women referred from a breast cancer screening program. We aimed to study the validity of preliminary results of CESM using a larger panel of radiologists with different levels of CESM experience. METHODS: All women referred from the Dutch breast cancer screening program were eligible for CESM. 199 consecutive cases were viewed by ten radiologists. Four had extensive CESM experience, three had no CESM experience but were experienced breast radiologists, and three were residents...
December 2016: European Radiology
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