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Spectral mammography

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https://www.readbyqxmd.com/read/28723585/clinical-utility-of-contrast-enhanced-spectral-mammography-as-an-adjunct-for-tomosynthesis-detected-architectural-distortion
#1
Bhavika K Patel, Michelle E Naylor, Heidi E Kosiorek, Yania M Lopez-Alvarez, Adrian M Miller, Victor J Pizzitola, Barbara A Pockaj
OBJECTIVE: Supplement tomosynthesis-detected architectural distortions (AD) with CESM to better characterize malignant vs benign lesions. METHODS: Retrospective review CESM prior to biopsied AD. Pathology: benign, radial scar, or malignant. RESULTS: 49 lesions (45 patients). 29 invasive cancers, 1 DCIS (range, 0.4-4.7cm); 9 radial scars; 10 benign. 37 (75.5%) ADs had associated enhancement. PPV 78.4% (29/37), sensitivity 96.7% (29/30); specificity, 57...
July 12, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28654337/newly-diagnosed-breast-cancer-comparison-of-contrast-enhanced-spectral-mammography-and-breast-mr-imaging-in-the-evaluation-of-extent-of-disease
#2
Stephanie A Lee-Felker, Leena Tekchandani, Mariam Thomas, Esha Gupta, Denise Andrews-Tang, Antoinette Roth, James Sayre, Guita Rahbar
Purpose To compare the diagnostic performances of contrast material-enhanced spectral mammography and breast magnetic resonance (MR) imaging in the detection of index and secondary cancers in women with newly diagnosed breast cancer by using histologic or imaging follow-up as the standard of reference. Materials and Methods This institutional review board-approved, HIPAA-compliant, retrospective study included 52 women who underwent breast MR imaging and contrast-enhanced spectral mammography for newly diagnosed unilateral breast cancer between March 2014 and October 2015...
June 26, 2017: Radiology
https://www.readbyqxmd.com/read/28541197/high-energy-resolution-hyperspectral-x-ray-imaging-for-low-dose-contrast-enhanced-digital-mammography
#3
Silvia Pani, Sarene Saifuddin, Filipa Ferreira, Nicholas Henthorn, Paul Seller, Paul Sellin, Philipp Stratmann, Matthew Veale, Matthew Wilson, Robert Cernik
Contrast-enhanced digital mammography (CEDM) is an alternative to conventional X-ray mammography for imaging dense breasts. However, conventional approaches to CEDM require a double exposure of the patient, implying higher dose and risk of incorrect image registration due to motion artifacts. A novel approach is presented, based on hyperspectral imaging, where a detector combining positional and high-resolution spectral information (in this case based on Cadmium Telluride) is used. This allows simultaneous acquisition of the two images required for CEDM...
May 18, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28532642/optical-mammography-in-patients-with-breast-cancer-undergoing-neoadjuvant-chemotherapy-individual-clinical-response-index
#4
Pamela G Anderson, Sirishma Kalli, Angelo Sassaroli, Nishanth Krishnamurthy, Shital S Makim, Roger A Graham, Sergio Fantini
RATIONALE AND OBJECTIVES: We present an optical mammography study that aims to develop quantitative measures of pathologic response to neoadjuvant chemotherapy (NAC) in patients with breast cancer. Such quantitative measures are based on the concentrations of oxyhemoglobin ([HbO2]), deoxyhemoglobin ([Hb]), total hemoglobin ([HbT]), and hemoglobin saturation (SO2) in breast tissue at the tumor location and at sequential time points during chemotherapy. MATERIALS AND METHODS: Continuous-wave, spectrally resolved optical mammography was performed in transmission and parallel-plate geometry on 10 patients before treatment initiation and at each NAC administration (mean number of optical mammography sessions: 12, range: 7-18)...
May 19, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28432828/quantitative-contrast-enhanced-spectral-mammography-based-on-photon-counting-detectors-a-feasibility-study
#5
Huanjun Ding, Sabee Molloi
PURPOSE: To investigate the feasibility of accurate quantification of iodine mass thickness in contrast-enhanced spectral mammography. MATERIALS AND METHODS: A computer simulation model was developed to evaluate the performance of a photon-counting spectral mammography system in the application of contrast-enhanced spectral mammography. A figure-of-merit (FOM), which was defined as the decomposed iodine signal-to-noise ratio (SNR) with respect to the square root of the mean glandular dose (MGD), was chosen to optimize the imaging parameters, in terms of beam energy, splitting energy, and pre-filtrations for breasts of various thicknesses and densities...
April 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28429382/direct-measurement-of-clinical-mammographic-x-ray-spectra-using-a-cdte-spectrometer
#6
Josilene C Santos, Alessandra Tomal, Tânia A Furquim, Agnes M F Fausto, Maria S Nogueira, Paulo R Costa
PURPOSE: To introduce and evaluate a method developed for the direct measurement of mammographic x-ray spectra using a CdTe spectrometer. The assembly of a positioning system and the design of a simple and customized alignment device for this application is described. METHODS: A positioning system was developed to easily and accurately locate the CdTe detector in the x-ray beam. Additionally, an alignment device to line up the detector with the central axis of the radiation beam was designed...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28421611/breast-density-measurement-using-photon-counting-spectral-mammography
#7
Henrik Johansson, Miriam von Tiedemann, Klaus Erhard, Harald Heese, Huanjun Ding, Sabee Molloi, Erik Fredenberg
PURPOSE: To evaluate a method for measuring breast density using photon-counting spectral mammography. Breast density is an indicator of breast cancer risk and diagnostic accuracy in mammography, and can be used as input to personalized screening, treatment monitoring and dose estimation. METHODS: The measurement method employs the spectral difference in x-ray attenuation between adipose and fibro-glandular tissue, and does not rely on any a priori information. The method was evaluated using phantom measurements on tissue-equivalent material (slabs and breast-shaped phantoms) and using clinical data from a screening population (n=1329)...
April 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28363948/false-negative-contrast-enhanced-spectral-mammography-use-of-more-than-one-imaging-modality-and-application-of-the-triple-test-avoids-misdiagnosis
#8
Donna Taylor, Susan O'Hanlon, Bruce Latham
A 50-year-old woman presented with chest tenderness. On examination, both breasts were lumpy. Bilateral mammography showed heterogeneously dense parenchyma, with possible stromal distortion laterally on the right at the 0900 position. On ultrasound (US), a corresponding 13×9×10 mm irregular hypoechoic mass with internal vascularity was noted and both breasts had a complex heterogeneous fibroglandular background pattern. US-guided core biopsy with marker clip insertion was performed with the diagnosis of a grade 2 invasive ductal carcinoma (IDC)...
March 31, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28332199/investigating-the-feasibility-of-classifying-breast-microcalcifications-using-photon-counting-spectral-mammography-a-simulation-study
#9
Bahaa Ghammraoui, Stephen J Glick
PURPOSE: A dual-energy material decomposition method using photon-counting spectral mammography was investigated as a non-invasive diagnostic approach to differentiate between Type I calcifications, consisting of calcium oxalate dihydrate or weddellite compounds that are more often associated with benign lesions, and Type II calcifications containing hydroxyapatite that are predominantly associated with malignant tumors. METHODS: The study was carried out by numerical simulation to assess the feasibility of the proposed approach...
March 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28303582/generation-and-analysis-of-clinically-relevant-breast-imaging-x-ray-spectra
#10
Andrew M Hernandez, J Anthony Seibert, Anita Nosratieh, John M Boone
PURPOSE: The purpose of this work was to develop and make available x-ray spectra for some of the most widely used digital mammography (DM), breast tomosynthesis (BT), and breast CT (bCT) systems in North America. METHODS: The Monte Carlo code MCNP6 was used to simulate minimally filtered (only beryllium) x-ray spectra at 8 tube potentials from 20 to 49 kV for DM/BT, and 9 tube potentials from 35 to 70 kV for bCT. Vendor-specific anode compositions, effective anode angles, focal spot sizes, source-to-detector distances, and beryllium filtration were simulated...
June 2017: Medical Physics
https://www.readbyqxmd.com/read/28226399/wavelet-based-scaling-indices-for-breast-cancer-diagnostics
#11
T Roberts, M Newell, W Auffermann, B Vidakovic
Mammography is routinely used to screen for breast cancer. However, the radiological interpretation of mammogram images is complicated by the heterogeneous nature of normal breast tissue and the fact that cancers are often of the same radiographic density as normal tissue. In this work, we use wavelets to quantify spectral slopes of breast cancer cases and controls and demonstrate their value in classifying images. In addition, we propose asymmetry statistics to be used in forming features, which improve the classification result...
May 30, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28112559/breast-radiation-dose-with-cesm-compared-with-2d-ffdm-and-3d-tomosynthesis-mammography
#12
COMPARATIVE STUDY
Judy R James, William Pavlicek, James A Hanson, Thomas F Boltz, Bhavika K Patel
OBJECTIVE: We aimed to compare radiation dose received during contrast-enhanced spectral mammography (CESM) using high- and low-energy projections with radiation dose received during 2D full field digital mammography (FFDM) and 3D tomosynthesis on phantoms and patients with varying breast thickness and density. MATERIALS AND METHODS: A single left craniocaudal projection was chosen to determine the doses for 6214 patients who underwent 2D FFDM, 3662 patients who underwent 3D tomosynthesis, and 173 patients who underwent CESM in this retrospective study...
February 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28107737/contrast-enhanced-spectral-mammography-cesm-versus-mri-in-the-high-risk-screening-setting-patient-preferences-and-attitudes
#13
Jordana Phillips, Matthew M Miller, Tejas S Mehta, Valerie Fein-Zachary, Audrey Nathanson, Wendy Hori, Rita Monahan-Earley, Priscilla J Slanetz
PURPOSE: Our study evaluates patient preferences toward screening CESM versus MRI. MATERIALS AND METHODS: As part of a prospective study, high-risk patients had breast MRI and CESM. Patients completed an anonymous survey to evaluate preferences regarding the two modalities. RESULTS: 88% of participants completed the survey. 79% preferred CESM over MRI if the exams had equal sensitivity. 89% would be comfortable receiving contrast as part of an annual screening test...
March 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28094850/discriminating-solitary-cysts-from-soft-tissue-lesions-in-mammography-using-a-pretrained-deep-convolutional-neural-network
#14
Thijs Kooi, Bram van Ginneken, Nico Karssemeijer, Ard den Heeten
PURPOSE: It is estimated that 7% of women in the western world will develop palpable breast cysts in their lifetime. Even though cysts have been correlated with risk of developing breast cancer, many of them are benign and do not require follow-up. We develop a method to discriminate benign solitary cysts from malignant masses in digital mammography. We think a system like this can have merit in the clinic as a decision aid or complementary to specialized modalities. METHODS: We employ a deep convolutional neural network (CNN) to classify cyst and mass patches...
March 2017: Medical Physics
https://www.readbyqxmd.com/read/28055247/staging-of-breast-cancer-and-the-advanced-applications-of-digital-mammogram-what-the-physician-needs-to-know
#15
Maha H Helal, Sahar M Mansour, Mai Zaglol, Lamia A Salaleldin, Omniya M Nada, Marwa A Haggag
OBJECTIVE: To study the role of advanced applications of digital mammogram, whether contrast-enhanced spectral mammography (CESM) or digital breast tomosynthesis (DBT), in the "T" staging of histologically proven breast cancer before planning for treatment management. METHODS: In this prospective analysis, we evaluated 98 proved malignant breast masses regarding their size, multiplicity and the presence of associated clusters of microcalcifications. Evaluation methods included digital mammography (DM), 3D tomosynthesis and CESM...
March 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28047752/we-de-207b-04-quantitative-contrast-enhanced-spectral-mammography-based-on-photon-counting-detectors-a-feasibility-study
#16
H Ding, B Zhou, D Beidokhti, S Molloi
PURPOSE: To investigate the feasibility of accurate quantification of iodine mass thickness in contrast-enhanced spectral mammography. METHODS: Experimental phantom studies were performed on a spectral mammography system based on Si strip photon-counting detectors. Dual-energy images were acquired using 40 kVp and a splitting energy of 34 keV with 3 mm Al pre-filtration. The initial calibration was done with glandular and adipose tissue equivalent phantoms of uniform thicknesses and iodine disk phantoms of various concentrations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047365/mo-fg-campus-iep1-01-alternative-k-edge-filters-for-low-energy-image-acquisition-in-contrast-enhanced-spectral-mammography
#17
S Shrestha, S Vedantham, A Karellas
PURPOSE: In Contrast Enhanced Spectral Mammography (CESM), Rh filter is often used during low-energy image acquisition. The potential for using Ag, In and Sn filters, which exhibit K-edge closer to, and just below that of Iodine, instead of the Rh filter, was investigated for the low-energy image acquisition. METHODS: Analytical computations of the half-value thickness (HVT) and the photon fluence per mAs (photons/mm2/mAs) for 50µm Rh were compared with other potential K-edge filters (Ag, In and Sn), all with K-absorption edge below that of Iodine...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047254/tu-d-209-01-dosimetry-of-diagnostic-work-up-mammography
#18
N Jallow, I Sechopoulos
PURPOSE: To investigate patient average glandular dose (AGD) characteristics of diagnostic mammography. METHODS: The techniques used to image 14420 patients who received diagnostic work up mammography from October 2008 to December 2014 at one academic hospital were retrospectively collected. The most common diagnostic views and the techniques used for each according to compressed breast thickness were determined. For all techniques, 1st half value layer and air kerma output per tube current-exposure time product were measured; then the incident air kerma for each acquisition was calculated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046981/we-de-207b-01-optimization-for-contrast-enhanced-spectral-mammography-based-on-photon-counting-detectors
#19
H Ding, S Molloi
PURPOSE: To investigate the feasibility of optimizing the imaging parameters for contrast-enhanced spectral mammography based on Si strip photon-counting detectors. METHODS: A computer simulation model using polyenergetic spectra from a tungsten anode x-ray tube and a Si-based photon-counting detector was evaluated for contrast-enhanced spectral mammography. The simulation traces the emission of photons from the x-ray source, attenuation through the breast and subsequent absorption in the detector...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046738/su-f-i-53-coded-aperture-coherent-scatter-spectral-imaging-of-the-breast-a-monte-carlo-evaluation-of-absorbed-dose
#20
R Morris, M Lakshmanan, G Fong, A Kapadia, J Greenberg
PURPOSE: Coherent scatter based imaging has shown improved contrast and molecular specificity over conventional digital mammography however the biological risks have not been quantified due to a lack of accurate information on absorbed dose. This study intends to characterize the dose distribution and average glandular dose from coded aperture coherent scatter spectral imaging of the breast. The dose deposited in the breast from this new diagnostic imaging modality has not yet been quantitatively evaluated...
June 2016: Medical Physics
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