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https://www.readbyqxmd.com/read/29334338/at-home-genital-nerve-stimulation-for-individuals-with-sci-and-neurogenic-detrusor-overactivity-a-pilot-feasibility-study
#1
Dennis J Bourbeau, Kenneth J Gustafson, Steven W Brose
OBJECTIVE: Neurogenic bladder dysfunction, including neurogenic detrusor overactivity (NDO) is one of the most clinically significant problems for persons with spinal cord injury (SCI), affecting health and quality of life. Genital nerve stimulation (GNS) can acutely inhibit NDO-related reflex bladder contractions and increase bladder capacity. However, it is unknown if GNS can improve urinary continence or help meet individuals' bladder management goals during sustained use, which is required for GNS to be clinically effective...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29331290/the-use-of-ultrasonography-to-identify-the-intersection-of-the-dorsomedial-cutaneous-nerve-of-the-hallux-and-the-extensor-hallucis-longus-tendon-a-cadaveric-study
#2
Matthew J Zdilla, Kyle D Miller, Jordan V Swearingen, H Wayne Lambert
Terminal branches of the superficial fibular nerve are at risk of iatrogenic damage during foot surgery, including hallux valgus rigidus correction, bunionectomy, cheilectomy, and extensor hallucis longus tendon transfer. One terminal branch, the dorsomedial cutaneous nerve of the hallux, is particularly at risk of injury at its intersection with the extensor hallucis longus tendon. Iatrogenic injuries of the dorsomedial cutaneous nerve of the hallux can result in sensory loss, neuroma formation, and/or debilitating causalgia...
January 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29331040/jun-gal-cd74-and-c1qb-as-potential-indicator-for-neuropathic-pain
#3
Ji-An Yang, Jun-Min He, Jing-Min Lu, Li-Juan Ji
Neuropathic pain is a kind of pain caused by primary or secondary impairment or dysfunction of peripheral or central nervous system. Patients with neuropathic pain were often with poor clinical outcome. We screened the differentially expressed genes between sciatic nerve injury and dorsal root ganglion gene in the sham operation model. Microarray and the spared nerve injury module were used to explore the molecular mechanism of neuropathic pain by injuries and the differentially expressed genes (DEGs) were identified out...
January 13, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29330780/safety-in-mixed-martial-arts-a-7-year-review-of-cancelled-mma-bouts-in-calgary-alberta-during-the-pre-bout-medical-examination-period
#4
Gwynn Curran-Sills
BACKGROUND: Presently, there is no literature that examines the reasons for the cancellation of amateur or professional mixed martial arts (MMA) bouts. The purpose of this study was to review the circumstances that lead to the cancellation of MMA bouts by Calgary ringside physicians during the pre-bout examination period and to identify any emerging patterns that may guide the regulatoin of this sport. METHODS: The case-series  was constructed from the Calgary Combative Sports Commission pre-bout examination records and the medical records submitted by each athlete from January 2010 to December 2016...
January 12, 2018: Sports Medicine—Open
https://www.readbyqxmd.com/read/29330728/analysis-of-plasma-tenascin-c-in-post-hcv-cirrhosis-a-prospective-study
#5
Jennifer H Benbow, April D Elam, Krista L Bossi, Danae L Massengill, Elizabeth Brandon-Warner, William E Anderson, Catherine R Culberson, Mark W Russo, Andrew S deLemos, Laura W Schrum
BACKGROUND AND AIM: Hepatitis C virus (HCV)-related cirrhosis, one of the most common etiologies of liver cirrhosis in the Western world, is a risk factor for hepatocellular carcinoma. To confirm and improve current effectiveness of screening and prognosis of patients with established cirrhosis, a credible, simple plasma biomarker is needed. Hepatic stellate cell activation, a pivotal event in cirrhosis development, results in increased secretion of extracellular matrix proteins, including tenascin-C (TnC)...
January 12, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29329669/prevalence-and-predictors-of-symptom-resolution-and-functional-restoration-in-the-index-knee-following-knee-arthroplasty-a-longitudinal-study
#6
Daniel L Riddle
OBJECTIVES: To determine the prevalence of a one- to two-year postsurgical pain-free state and pain plus symptom-free state as well as function restoration following knee arthroplasty (KA). A second purpose was to identify predictors of these outcomes. DESIGN: An inception cohort from the Osteoarthritis Initiative (OAI) dataset, a nine-year NIH funded cohort study of persons with or at high risk for knee osteoarthritis was studied. SETTING: Subjects were recruited from the communities of four sites in the Midwest, Eastern and Southeastern United States...
January 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29327826/correlation-between-hypermobility-score-and-injury-rate-in-artistic-gymnastics
#7
Bojan Bukva, Goran Vrgoč, Dejan Madić, Goran Sporiš, Nebojša Trajković
BACKGROUND: Generalized Joint Hypermobility (GJH) is suggested as a contributing factor for injuries in young athletes and adults. It is presumed that GJH causes decreased joint stability, thereby increasing the risk of joint and soft tissue injuries during sports activities. The aim of this study was to determine the correlation between the hypermobility rate (using the Beighton`s modification of the Carter-Wilkinson criteria of hypermobility) in gymnasts and injury rate, during the period of one year...
January 10, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29327631/the-association-between-adverse-childhood-experiences-and-adult-traumatic-brain-injury-concussion-a-scoping-review
#8
Zechen Ma, Mark T Bayley, Laure Perrier, Priya Dhir, Lana Dépatie, Paul Comper, Lesley Ruttan, Christine Lay, Sarah E P Munce
BACKGROUND: Adverse childhood experiences are significant risk factors for physical and mental illnesses in adulthood. Traumatic brain injury/concussion is a challenging condition where pre-injury factors may affect recovery. The association between childhood adversity and traumatic brain injury/concussion has not been previously reviewed. The research question addressed is: What is known from the existing literature about the association between adverse childhood experiences and traumatic brain injury/concussion in adults? METHODS: All original studies of any type published in English since 2007 on adverse childhood experiences and traumatic brain injury/concussion outcomes were included...
January 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29325893/stilamin-inhibits-intestinal-and-pancreatic-injury-in-rats-with-severe-acute-pancreatitis-by-down-regulating-lcn2-expression
#9
Yifan Ren, Qing Cui, Jianbin Bi, Zhaoqing Du, Jia Zhang, Xufeng Zhang, Yi Lv, Rongqian Wu
OBJECTIVE: This study was aimed at exploring the function and mechanism of Stilamin on severe acute pancreatitis (SAP) in rats. METHODS: We analyzed the histology of small intestine and pancreatic tissues of SAP rats and SAP rats plus treatment with Stilamin. The expression levels of IL-6 and TNF-α in serum were detected using ELISA. The expressions of Caspase-3, bcl-2, Bax and p53 in rat tissues of SAP group were verified by qRT-PCR and western blot. The differential expressed mRNAs in rats of SAP group were screened out by microarray analysis...
January 2, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29325790/how-do-oral-and-maxillofacial-surgeons-manage-concussion
#10
D Hammond, R Welbury, G Sammons, E Toman, M Harland, S Rice
Craniofacial trauma results in distracting injuries that are easy to see, and as oral and maxillofacial surgeons (OMFS) we gravitate towards injuries that can be seen and are treatable surgically. However, we do tend not to involve ourselves (and may potentially overlook) injuries that are not obvious either visually or radiographically, and concussion is one such. We reviewed the records of 500 consecutive patients who presented with facial fractures at the Queen Elizabeth Hospital, Birmingham, to identify whether patients had been screened for concussion, and how they had been managed...
January 8, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29325346/-evidence-based-guideline-for-the-management-of-acute-subaxial-cervical-spine-injury
#11
(no author information available yet)
In order to provide the clinical guidelines of acute subaxial cervical spine injury for the Chinese orthopedic surgeons, the Spine Trauma Group of Chinese Association of Orthopedic Surgeons compiled this guidelines.The guidelines apply to adult patients with acute (less than 3 weeks) subaxial cervical spine and/(or) spinal cord or nerve root injuries. The Study Group wrote the guidelines by setting up questions, determining search words, screening literatures according to inclusion and exclusion criteria, analyzing the included literatures, confirming evidence levels and then providing recommendations...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29323915/resonance-energy-transfer-promoted-photothermal-and-photodynamic-performance-of-gold-copper-sulfide-yolk-shell-nanoparticles-for-chemophototherapy-of-cancer
#12
Yun Chang, Yan Cheng, Yanlin Feng, Hui Jian, Li Wang, Xiaomin Ma, Xi Li, Haiyuan Zhang
Gold (Au) core@void@copper sulfide (CuS) shell (Au-CuS) yolk-shell nanoparticles (YSNPs) were prepared in the present study for potential chemo-, photothermal, and photodynamic combination therapy, so called "chemophototherapy". The resonance energy transfer (RET) process was utilized in Au-CuS YSNPs to achieve both enhanced photothermal and photodynamic performance compared with those of CuS hollow nanoparticles (HNPs). A series of Au nanomaterials as cores that had different localized surface plasmon resonance (LSPR) absorption peaks at 520, 700, 808, 860, and 980 nm were embedded in CuS HNPs to screen the most effective Au-CuS YSNPs according to the RET process...
January 11, 2018: Nano Letters
https://www.readbyqxmd.com/read/29322861/community-mobility-after-stroke-a-systematic-review
#13
Steven Wesselhoff, Timothy A Hanke, Christian C Evans
Background Stroke is the leading cause of severe disability and many survivors report long-term physical or cognitive impairments that may impact their ability to achieve community mobility (CM). PURPOSE: To determine the extent to which people with chronic stroke achieve CM compared to age-matched norms or non-neurologically impaired controls. Methods The StrokEDGE outcome measures were searched to identify validated tools that included >25% of items addressing CM. MEDLINE, CINAHL, Google Scholar, PubMed, PEDro and the Cochrane databases were searched from 2001 to 2015 with the identified outcome measures cross-referenced against search terms related to stroke and CM...
January 11, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29321142/differentiating-primary-genetic-and-secondary-fsgs-in-adults-a-clinicopathologic-approach
#14
An S De Vriese, Sanjeev Sethi, Karl A Nath, Richard J Glassock, Fernando C Fervenza
FSGS describes a renal histologic lesion with diverse causes and pathogenicities that are linked by podocyte injury and depletion. Subclasses of FSGS include primary, genetic, and secondary forms, the latter comprising maladaptive, viral, and drug-induced FSGS. Despite sharing certain clinical and histologic features, these subclasses differ noticeably in management and prognosis. Without an accepted nongenetic biomarker that discriminates among these FSGS types, classification of patients is often challenging...
January 10, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29320946/cognitive-demands-influence-lower-extremity-mechanics-during-a-drop-vertical-jump-task-in-female-athletes
#15
Thomas Gus Almonroeder, Thomas Kernozek, Stephen Cobb, Brooke Slavens, Jinsung Wang, Wendy Huddleston
Study Design Cross-sectional study. Background The drop vertical jump task is commonly used in anterior cruciate ligament injury risk screening; however, the predictive validity is limited. Part of the limited predictive validity may be because the drop vertical jump task does not impose cognitive demands that reflect sports participation. Objectives To investigate the influence of additional cognitive demands on lower extremity mechanics during execution of the drop vertical jump task. Methods Twenty uninjured females (ages 18-25 years old) were required to perform the standard drop vertical jump task, as well as drop vertical jumps which included additional cognitive demands...
January 10, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29320924/a-model-to-evaluate-pauwels-type-iii-femoral-neck-fractures
#16
Kevin M Magone, Jonas K Owen, Bernard P Kemker, Oliver Bloom, Sidney Martin, Patrick Atkinson
While many femoral neck fractures can be reliably treated with surgical intervention, Pauwels III femoral neck fractures in the young adult population continue to be a challenging injury, and there is no consensus on optimal treatment. As such, there are past and ongoing biomechanical studies to evaluate the fixation provided by different constructs for this inherently unstable fracture. While many investigations rely on cadavers to evaluate the biomechanical performance of a construct, significant inter-subject variability can confound the analysis...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29317708/connexin-43-hemichannel-as-a-novel-mediator-of-sterile-and-infectious-inflammatory-diseases
#17
Wei Li, Guoqiang Bao, Weiqiang Chen, Xiaoling Qiang, Shu Zhu, Shuaiwei Wang, Mingzhu He, Gaifeng Ma, Mahendar Ochani, Yousef Al-Abed, Huan Yang, Kevin J Tracey, Ping Wang, John D'Angelo, Haichao Wang
Cytoplasmic membrane-bound connexin 43 (Cx43) proteins oligomerize into hexameric channels (hemichannels) that can sometimes dock with hemichannels on adjacent cells to form gap junctional (GJ) channels. However, the possible role of Cx43 hemichannels in sterile and infectious inflammatory diseases has not been adequately defined due to the lack of selective interventions. Here we report that a proinflammatory mediator, the serum amyloid A (SAA), resembled bacterial endotoxin by stimulating macrophages to up-regulate Cx43 expression and double-stranded RNA-activated protein kinase R (PKR) phosphorylation in a TLR4-dependent fashion...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316623/neurodegeneration-and-sensorimotor-deficits-in-the-mouse-model-of-traumatic-brain-injury
#18
Saurav Bhowmick, Veera D'Mello, Nizmi Ponery, P M Abdul-Muneer
Traumatic brain injury (TBI) can result in persistent sensorimotor and cognitive deficits, which occur through a cascade of deleterious pathophysiological events over time. In this study, we investigated the hypothesis that neurodegeneration caused by TBI leads to impairments in sensorimotor function. TBI induces the activation of the caspase-3 enzyme, which triggers cell apoptosis in an in vivo model of fluid percussion injury (FPI). We analyzed caspase-3 mediated apoptosis by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and poly (ADP-ribose) polymerase (PARP) and annexin V western blotting...
January 6, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29312999/covertly-active-and-progressing-neurochemical-abnormalities-in-suppressed-hiv-infection
#19
Lucette A Cysique, Lauriane Jugé, Thomas Gates, Michael Tobia, Kirsten Moffat, Bruce J Brew, Caroline Rae
Objective: To assess whether HIV-related brain injury is progressive in persons with suppressed HIV infection. Methods: Seventy-three HIV+ virally suppressed men and 35 HIV- men, screened for psychiatric and alcohol/drug use disorders, underwent neuropsychological evaluation and proton magnetic resonance spectroscopy (1H-MRS) at baseline and after and 23 ± 5 months. 1H-MRS included brain regions known to be vulnerable to HIV and aging: frontal white matter (FWM), posterior cingulate cortex (PCC), and caudate area (CA)...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29312533/loss-of-pacs-2-delays-regeneration-in-dss-induced-colitis-but-does-not-affect-the-apcmin-model-of-colorectal-cancer
#20
Sarah L Dombernowsky, Jeanette Schwarz, Jacob Samsøe-Petersen, Reidar Albrechtsen, Kim B Jensen, Gary Thomas, Marie Kveiborg
PACS-2 is a multifunctional sorting protein that mediates cell homeostasis. We recently identified PACS-2 in a functional genome-wide siRNA screen for novel regulators of the metalloproteinase ADAM17, the main sheddase for ligands of the ErbB receptor family. Of note, we showed that Pacs2-/- mice have significantly reduced EGFR activity and proliferative index in the intestinal epithelium. As EGFR signaling is highly mitogenic for intestinal epithelial stem cells, and plays essential roles in intestinal epithelial regeneration and tumor development, we have now examined the role of PACS-2 in these processes...
December 12, 2017: Oncotarget
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