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JOURNAL ARTICLE
Flavia Chiuppesi, Sandra Ortega-Francisco, Miguel-Angel Gutierrez, Jing Li, Minh Ly, Katelyn Faircloth, Jada Mack-Onyeike, Corinna La Rosa, Sandra Thomas, Qiao Zhou, Jennifer Drake, Cynthia Slape, Paolo Fernando, Wasima Rida, Teodora Kaltcheva, Alba Grifoni, Alessandro Sette, Angela Patterson, Shannon Dempsey, Brian Ball, Haris Ali, Amandeep Salhotra, Anthony Stein, Nitya Nathwani, Michael Rosenzweig, Liana Nikolaenko, Monzr M Al Malki, Jana Dickter, Deepa D Nanayakkara, Alfredo Puing, Stephen J Forman, Randy A Taplitz, John A Zaia, Ryotaro Nakamura, Felix Wussow, Don J Diamond, Sanjeet S Dadwal
Hematopoietic cell transplantation (HCT) and chimeric antigen receptor (CAR)-T cell patients are immunocompromised, remain at high risk following SARS-CoV-2 infection, and are less likely than immunocompetent individuals to respond to vaccination. As part of the safety lead-in portion of a phase 2 clinical trial in patients post HCT/CAR-T for hematological malignancies (HM), we tested the immunogenicity of the synthetic modified vaccinia Ankara-based COVID-19 vaccine COH04S1 co-expressing spike (S) and nucleocapsid (N) antigens...
September 15, 2023: Vaccines
#22
JOURNAL ARTICLE
Tanner M Filben, Brian T Tomblin, N Stewart Pritchard, Garrett S Bullock, Jordan M Hemmen, Kristina E Neri, Victoria Krug, Christopher M Miles, Joel D Stitzel, Jillian E Urban
There is concern that exposure to soccer headers may be associated with neurological sequelae. Training proper heading technique represents a coachable intervention that may reduce head acceleration exposure. The objective was to assess relationships between heading technique and head kinematics in female youth soccer players. Fourteen players (mean age = 14.4 years) wore instrumented mouthpieces during practices and games. Headers were reviewed by three raters to assign a technique score...
September 27, 2023: Science & medicine in football
#23
JOURNAL ARTICLE
Lindsay Bochon, Brian M Bird, Neil V Watson
Exclusion from social relationships is a painful experience that may threaten an individual's status and dominance. The steroid hormone testosterone, which fluctuates rapidly in response to such threats, may be implicated in subsequent behavioral action (e.g., aggressive or prosocial responses) that aims to protect or enhance one's status after exclusion. Past research, however, indicates that the link between acute changes in testosterone and behavior depend on context-relevant individual dispositions. In the context of social exclusion, an individual's level of shame proneness-characterized by a tendency to experience shame and to react submissively-is theoretically relevant to the testosterone-induced aggression relationship but has yet to be examined empirically...
August 3, 2023: Psychoneuroendocrinology
#24
REVIEW
Edward C Dominguez, Carly Roleder, Brian Ball And, Alexey V Danilov
Cyclin-dependent kinases (CDK) regulate cell cycle and transcriptional activity. Pan-CDK inhibitors demonstrated early efficacy in lymphoid malignancies, but also have been associated with narrow therapeutic index. Among transcriptional CDKs, CDK7 and CDK9 emerged as promising targets. CDK9 serves as a component of p-TEFb elongation complex and thus is indispensable in mRNA transcription. Selective CDK9 inhibitors demonstrated pre-clinical efficacy in in vitro and in vivo models of B-cell non-Hodgkin lymphoma...
August 8, 2023: Leukemia & Lymphoma
#25
JOURNAL ARTICLE
Brandon R Desousa, Kristen Ko Kim, Anthony E Jones, Andréa B Ball, Wei Y Hsieh, Pamela Swain, Danielle H Morrow, Alexandra J Brownstein, David A Ferrick, Orian S Shirihai, Andrew Neilson, David A Nathanson, George W Rogers, Brian P Dranka, Anne N Murphy, Charles Affourtit, Steven J Bensinger, Linsey Stiles, Natalia Romero, Ajit S Divakaruni
Oxidative phosphorylation and glycolysis are the dominant ATP-generating pathways in mammalian metabolism. The balance between these two pathways is often shifted to execute cell-specific functions in response to stimuli that promote activation, proliferation, or differentiation. However, measurement of these metabolic switches has remained mostly qualitative, making it difficult to discriminate between healthy, physiological changes in energy transduction or compensatory responses due to metabolic dysfunction...
August 7, 2023: EMBO Reports
#26
JOURNAL ARTICLE
Ahmed Aribi, Amandeep Salhotra, Michelle Afkhami, Anamaria Munteanu, Haris Ali, Ibrahim Aldoss, Salman Otoukesh, Monzr M Al Malki, Karamjeet S Sandhu, Paul Koller, Shukaib Arslan, Forrest Stewart, Andrew Artz, Peter Curtin, Brian Ball, James O'Hearn, Ricardo Spielberger, Eileen Smith, Elizabeth Budde, Ryotaro Nakamura, Anthony Stein, Stephen Forman, Guido Marcucci, Pamela S Becker, Vinod Pullarkat
We conducted a retrospective analysis of WT1- mutated acute myeloid leukemia (AML) patients who underwent allogeneic stem cell transplant. Thirty-seven patients with WT1- mutated AML were identified. Primary induction failure (40%) and early relapse rate (18%) after idarubicin/cytarabine (7 + 3) chemotherapy were observed. All patients with induction failure subsequently achieved CR with additional chemotherapy. There was no significant difference between outcomes after myeloablative vs. reduced intensity (Fludarabine/Melphalan [Flu/Mel]) conditioning regimens...
August 3, 2023: Leukemia & Lymphoma
#27
JOURNAL ARTICLE
Peter J Embi, Matthew E Levy, Palak Patel, Malini B DeSilva, Manjusha Gaglani, Kristin Dascomb, Margaret M Dunne, Nicola P Klein, Toan C Ong, Shaun J Grannis, Karthik Natarajan, Duck-Hye Yang, Edward Stenehjem, Ousseny Zerbo, Charlene McEvoy, Suchitra Rao, Mark G Thompson, Deepika Konatham, Stephanie A Irving, Brian E Dixon, Jungmi Han, Kristin E Schrader, Nancy Grisel, Ned Lewis, Anupam B Kharbanda, Michelle A Barron, Sue Reynolds, I-Chia Liao, William F Fadel, Elizabeth A Rowley, Julie Arndorfer, Kristin Goddard, Kempapura Murthy, Nimish R Valvi, Zachary A Weber, Bruce Fireman, Sarah E Reese, Sarah W Ball, Allison L Naleway
BACKGROUND: Immunocompromised (IC) persons are at increased risk for severe COVID-19 outcomes and are less protected by 1-2 COVID-19 vaccine doses than are immunocompetent (non-IC) persons. We compared vaccine effectiveness (VE) against medically attended COVID-19 of 2-3 mRNA and 1-2 viral-vector vaccine doses between IC and non-IC adults. METHODS: Using a test-negative design among eight VISION Network sites, VE against laboratory-confirmed COVID-19-associated emergency department (ED) or urgent care (UC) events and hospitalizations from 26 August-25 December 2021 was estimated separately among IC and non-IC adults and among specific IC condition subgroups...
May 22, 2023: Vaccine
#28
REVIEW
Peter White, Susan Abbey, Brian Angus, Harriet A Ball, Dedra S Buchwald, Christine Burness, Alan J Carson, Trudie Chalder, Daniel J Clauw, Jan Coebergh, Anthony S David, Barbara A Dworetzky, Mark J Edwards, Alberto J Espay, John Etherington, Per Fink, Signe Flottorp, Béatrice Garcin, Paul Garner, Paul Glasziou, Willie Hamilton, Peter Henningsen, Ingrid Hoeritzauer, Mujtaba Husain, Anne-Catherine M L Huys, Hans Knoop, Kurt Kroenke, Alexander Lehn, James L Levenson, Paul Little, Andrew Lloyd, Ira Madan, Jos W M van der Meer, Alastair Miller, Maurice Murphy, Irwin Nazareth, David L Perez, Wendy Phillips, Markus Reuber, Winfried Rief, Alastair Santhouse, Tereza Serranova, Michael Sharpe, Biba Stanton, Donna E Stewart, Jon Stone, Michele Tinazzi, Derick T Wade, Simon C Wessely, Vegard Wyller, Adam Zeman
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disabling long-term condition of unknown cause. The National Institute for Health and Care Excellence (NICE) published a guideline in 2021 that highlighted the seriousness of the condition, but also recommended that graded exercise therapy (GET) should not be used and cognitive-behavioural therapy should only be used to manage symptoms and reduce distress, not to aid recovery. This U-turn in recommendations from the previous 2007 guideline is controversial...
December 2023: Journal of Neurology, Neurosurgery, and Psychiatry
#29
JOURNAL ARTICLE
Ruth Link-Gelles, Zachary A Weber, Sarah E Reese, Amanda B Payne, Manjusha Gaglani, Katherine Adams, Anupam B Kharbanda, Karthik Natarajan, Malini B DeSilva, Kristin Dascomb, Stephanie A Irving, Nicola P Klein, Shaun J Grannis, Toan C Ong, Peter J Embi, Margaret M Dunne, Monica Dickerson, Charlene McEvoy, Julie Arndorfer, Allison L Naleway, Kristin Goddard, Brian E Dixon, Eric P Griggs, John Hansen, Nimish Valvi, Morgan Najdowski, Julius Timbol, Colin Rogerson, Bruce Fireman, William F Fadel, Palak Patel, Caitlin S Ray, Ryan Wiegand, Sarah Ball, Mark W Tenforde
No abstract text is available yet for this article.
July 2023: American Journal of Transplantation
#30
JOURNAL ARTICLE
Katherine Adams, John J Riddles, Elizabeth A K Rowley, Shaun J Grannis, Manjusha Gaglani, Bruce Fireman, Emily Hartmann, Allison L Naleway, Edward Stenehjem, Alexandria Hughes, Alexandra F Dalton, Karthik Natarajan, Kristin Dascomb, Chandni Raiyani, Stephanie A Irving, Chantel Sloan-Aagard, Anupam B Kharbanda, Malini B DeSilva, Brian E Dixon, Toan C Ong, Jean Keller, Monica Dickerson, Nancy Grisel, Kempapura Murthy, Juan Nanez, William F Fadel, Sarah W Ball, Palak Patel, Julie Arndorfer, Mufaddal Mamawala, Nimish R Valvi, Margaret M Dunne, Eric P Griggs, Peter J Embi, Mark G Thompson, Ruth Link-Gelles, Mark W Tenforde
BACKGROUND: Understanding the usefulness of additional COVID-19 vaccine doses-particularly given varying disease incidence-is needed to support public health policy. We characterize the benefits of COVID-19 booster doses using number needed to vaccinate (NNV) to prevent one COVID-19-associated hospitalization or emergency department encounter. METHODS: We conducted a retrospective cohort study of immunocompetent adults at five health systems in four U.S. states during SARS-CoV-2 Omicron BA...
July 2023: Lancet Reg Health Am
#31
JOURNAL ARTICLE
Sunil K Ahuja, Muthu Saravanan Manoharan, Grace C Lee, Lyle R McKinnon, Justin A Meunier, Maristella Steri, Nathan Harper, Edoardo Fiorillo, Alisha M Smith, Marcos I Restrepo, Anne P Branum, Matthew J Bottomley, Valeria Orrù, Fabio Jimenez, Andrew Carrillo, Lavanya Pandranki, Caitlyn A Winter, Lauryn A Winter, Alvaro A Gaitan, Alvaro G Moreira, Elizabeth A Walter, Guido Silvestri, Christopher L King, Yong-Tang Zheng, Hong-Yi Zheng, Joshua Kimani, T Blake Ball, Francis A Plummer, Keith R Fowke, Paul N Harden, Kathryn J Wood, Martin T Ferris, Jennifer M Lund, Mark T Heise, Nigel Garrett, Kristen R Canady, Salim S Abdool Karim, Susan J Little, Sara Gianella, Davey M Smith, Scott Letendre, Douglas D Richman, Francesco Cucca, Hanh Trinh, Sandra Sanchez-Reilly, Joan M Hecht, Jose A Cadena Zuluaga, Antonio Anzueto, Jacqueline A Pugh, Brian K Agan, Robert Root-Bernstein, Robert A Clark, Jason F Okulicz, Weijing He
Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as the capacity to preserve and/or rapidly restore immune functions that promote disease resistance (immunocompetence) and control inflammation in infectious diseases as well as other causes of inflammatory stress. We gauge IR levels with two distinct peripheral blood metrics that quantify the balance between (i) CD8+ and CD4+ T-cell levels and (ii) gene expression signatures tracking longevity-associated immunocompetence and mortality-associated inflammation...
June 13, 2023: Nature Communications
#32
RANDOMIZED CONTROLLED TRIAL
Michael G Fehlings, Ali Moghaddamjou, James S Harrop, Ralph Stanford, Jonathon Ball, Bizhan Aarabi, Brian J C Freeman, Paul M Arnold, James D Guest, Shekar N Kurpad, James M Schuster, Ahmad Nassr, Karl M Schmitt, Jefferson R Wilson, Darrel S Brodke, Faiz U Ahmad, Albert Yee, Wilson Z Ray, Nathaniel P Brooks, Jason Wilson, Diana S-L Chow, Elizabeth G Toups, Branko Kopjar
Riluzole is a sodium-glutamate antagonist that attenuates neurodegeneration in amyotrophic lateral sclerosis (ALS). It has shown favorable results in promoting recovery in pre-clinical models of traumatic spinal cord injury (tSCI) and in early phase clinical trials. This study aimed to evaluate the efficacy and safety of riluzole in acute cervical tSCI. An international, multi-center, prospective, randomized, double-blinded, placebo-controlled, adaptive, Phase III trial (NCT01597518) was undertaken. Patients with American Spinal Injury Association Impairment Scale (AIS) A-C, cervical (C4-C8) tSCI, and <12 h from injury were randomized to receive either riluzole, at an oral dose of 100 mg twice per day (BID) for the first 24 h followed by 50 mg BID for the following 13 days, or placebo...
September 2023: Journal of Neurotrauma
#33
JOURNAL ARTICLE
Ruth Link-Gelles, Zachary A Weber, Sarah E Reese, Amanda B Payne, Manjusha Gaglani, Katherine Adams, Anupam B Kharbanda, Karthik Natarajan, Malini B DeSilva, Kristin Dascomb, Stephanie A Irving, Nicola P Klein, Shaun J Grannis, Toan C Ong, Peter J Embi, Margaret M Dunne, Monica Dickerson, Charlene McEvoy, Julie Arndorfer, Allison L Naleway, Kristin Goddard, Brian E Dixon, Eric P Griggs, John Hansen, Nimish Valvi, Morgan Najdowski, Julius Timbol, Colin Rogerson, Bruce Fireman, William F Fadel, Palak Patel, Caitlin S Ray, Ryan Wiegand, Sarah Ball, Mark W Tenforde
On September 1, 2022, CDC's Advisory Committee on Immunization Practices (ACIP) recommended a single bivalent mRNA COVID-19 booster dose for persons aged ≥12 years who had completed at least a monovalent primary series. Early vaccine effectiveness (VE) estimates among adults aged ≥18 years showed receipt of a bivalent booster dose provided additional protection against COVID-19-associated emergency department and urgent care visits and hospitalizations compared with that in persons who had received only monovalent vaccine doses (1); however, insufficient time had elapsed since bivalent vaccine authorization to assess the durability of this protection...
May 26, 2023: MMWR. Morbidity and Mortality Weekly Report
#34
JOURNAL ARTICLE
Janny M Yao, Salman Otoukesh, Hanna Kim, Dongyun Yang, Sally Mokhtari, Yazeed Samara, Amanda Blackmon, Shukaib Arslan, Vaibhav Agrawal, Hoda Pourhassan, Idoroenyi Amanam, Brian Ball, Paul Koller, Amandeep Salhotra, Pamela Becker, Peter Curtin, Andrew Artz, Ibrahim Aldoss, Haris Ali, Forrest Stewart, Eileen Smith, Anthony Stein, Guido Marcucci, Stephen J Forman, Ryotaro Nakamura, Monzr M Al Malki
BACKGROUND: Cytokine release syndrome (CRS) is a common complication after haploidentical hematopoietic cell transplant (HaploHCT). Severe CRS after haploHCT leads to higher risk of non-relapse mortality (NRM) and worse overall survival (OS). Tocilizumab (TOCI) is an interleukin-6 receptor inhibitor and is commonly used as first-line for CRS management after chimeric antigen receptor T cell therapy, but the impact of TOCI administration for CRS management on Haplo HCT outcomes is not known...
May 12, 2023: Transplantation and cellular therapy
#35
JOURNAL ARTICLE
Joseph G W McCarter, David Nemirovsky, Christopher A Famulare, Noushin Farnoud, Abhinita S Mohanty, Zoe S Stone-Molloy, Jordan Chervin, Brian J Ball, Zachary D Epstein-Peterson, Maria E Arcila, Aaron J Stonestrom, Andrew Dunbar, Sheng F Cai, Jacob L Glass, Mark B Geyer, Raajit K Rampal, Ellin Berman, Omar I Abdel-Wahab, Eytan M Stein, Martin S Tallman, Ross L Levine, Aaron D Goldberg, Elli Papaemmanuil, Yanming Zhang, Mikhail Roshal, Andriy Derkach, Wenbin Xiao
Accurate classification and risk stratification is critical for clinical decision making in AML patients. In the newly proposed World Health Organization (WHO) and International Consensus classifications (ICC) of hematolymphoid neoplasms, the presence of myelodysplasia-related (MR) gene mutations is included as one of the diagnostic criteria of AML, myelodysplasia-related (AML-MR), largely based on the assumption that these mutations are specific for AML with an antecedent myelodysplastic syndrome. ICC also prioritizes MR gene mutations over ontogeny (as defined by clinical history)...
May 4, 2023: Blood Advances
#36
JOURNAL ARTICLE
Jörg Freyhof, Matthias F Geiger, Sarah Ball, Brian Zimmerman
DNA barcodes (COI) of Troglocobitis starostini, endemic to a single site in Turkmenistan, were analysed and put into the taxonomic context of the large group of nemacheilid loaches known from Western and Central Asia. All applied phylogenetic tree-based analyses place the species into the genus Paracobitis. This finding supports previous morphological studies. While the exact position of Troglocobitis starostini within Paracobitis was not resolved unambiguously, it was constantly recovered within Paracobitis, irrespective of the tree reconstruction method applied...
September 30, 2022: Zootaxa
#37
JOURNAL ARTICLE
Nicola P Klein, Maria Demarco, Katherine E Fleming-Dutra, Melissa S Stockwell, Anupam B Kharbanda, Manjusha Gaglani, Suchitra Rao, Ned Lewis, Stephanie A Irving, Emily Hartmann, Karthik Natarajan, Alexandra F Dalton, Ousseny Zerbo, Malini B DeSilva, Deepika Konatham, Edward Stenehjem, Elizabeth A K Rowley, Toan C Ong, Shaun J Grannis, Chantel Sloan-Aagard, Jungmi Han, Jennifer R Verani, Chandni Raiyani, Kristin Dascomb, Sarah E Reese, Michelle A Barron, William F Fadel, Allison L Naleway, Juan Nanez, Monica Dickerson, Kristin Goddard, Kempapura Murthy, Nancy Grisel, Zacharay A Weber, Brian E Dixon, Palak Patel, Bruce Fireman, Julie Arndorfer, Nimish R Valvi, Eric P Griggs, Carly Hallowell, Peter J Embi, Sarah W Ball, Mark G Thompson, Mark W Tenforde, Ruth Link-Gelles
OBJECTIVES: We assessed BNT162b2 vaccine effectiveness (VE) against mild to moderate and severe coronavirus disease 2019 (COVID-19) in children and adolescents through the Omicron BA.4/BA.5 period. METHODS: Using VISION Network records from April 2021 to September 2022, we conducted a test-negative, case-control study assessing VE against COVID-19-associated emergency department/urgent care (ED/UC) encounters and hospitalizations using logistic regression, conditioned on month and site, adjusted for covariates...
April 7, 2023: Pediatrics
#38
JOURNAL ARTICLE
Engy T Said, Brennan P Marsh-Armstrong, Seth J Fischer, Preetham J Suresh, Matthew W Swisher, Andrea M Trescot, J David Prologo, Baharin Abdullah, Brian M Ilfeld
INTRODUCTION: Ultrasound-guided percutaneous cryoneurolysis provides analgesia using cold temperatures to reversibly ablate peripheral nerves. Cryoneurolysis probes pass a gas through a small internal annulus, rapidly lowering the pressure and temperature, forming an ice ball to envelope the target nerve. Analgesia is compromised if a nerve is inadequately frozen, and laboratory studies suggest that pain may be paradoxically induced with a magnitude and duration in proportion with the incomplete ablation...
March 31, 2023: Pain and Therapy
#39
JOURNAL ARTICLE
Elana Thieme, Nur Bruss, Duanchen Sun, Edward C Dominguez, Daniel Coleman, Tingting Liu, Carly Roleder, Melissa Martinez, Krystine Garcia-Mansfield, Brian Ball, Patrick Pirrotte, Lili Wang, Zheng Xia, Alexey V Danilov
Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which contributes to drug resistance, necessitating development of novel therapeutic approaches. Pharmacological inhibitors of cyclin-dependent kinases (CDK) demonstrated pre-clinical activity in DLBCL, however many stalled in clinical development. Here we show that AZD4573, a selective inhibitor of CDK9, restricted growth of DLBCL cells. CDK9 inhibition (CDK9i) resulted in rapid changes in the transcriptome and proteome, with downmodulation of multiple oncoproteins (eg, MYC, Mcl-1, JunB, PIM3) and deregulation of phosphoinotiside-3 kinase (PI3K) and senescence pathways...
March 30, 2023: Molecular Cancer
#40
JOURNAL ARTICLE
Ruth Link-Gelles, Matthew E Levy, Karthik Natarajan, Sarah E Reese, Allison L Naleway, Shaun J Grannis, Nicola P Klein, Malini B DeSilva, Toan C Ong, Manjusha Gaglani, Emily Hartmann, Monica Dickerson, Edward Stenehjem, Anupam B Kharbanda, Jungmi Han, Talia L Spark, Stephanie A Irving, Brian E Dixon, Ousseny Zerbo, Charlene E McEvoy, Suchitra Rao, Chandni Raiyani, Chantel Sloan-Aagard, Palak Patel, Kristin Dascomb, Anne-Catrin Uhlemann, Margaret M Dunne, William F Fadel, Ned Lewis, Michelle A Barron, Kempapura Murthy, Juan Nanez, Eric P Griggs, Nancy Grisel, Medini K Annavajhala, Akintunde Akinseye, Nimish R Valvi, Kristin Goddard, Mufaddal Mamawala, Julie Arndorfer, Duck-Hye Yang, Peter J Embí, Bruce Fireman, Sarah W Ball, Mark W Tenforde
IMPORTANCE: Recent SARS-CoV-2 Omicron variant sublineages, including BA.4 and BA.5, may be associated with greater immune evasion and less protection against COVID-19 after vaccination. OBJECTIVES: To evaluate the estimated vaccine effectiveness (VE) of 2, 3, or 4 doses of COVID-19 mRNA vaccination among immunocompetent adults during a period of BA.4 or BA.5 predominant circulation; and to evaluate the relative severity of COVID-19 in hospitalized patients across Omicron BA...
March 1, 2023: JAMA Network Open
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