keyword
https://read.qxmd.com/read/38533973/50-nm-gas-filled-protein-nanostructures-to-enable-the-access-of-lymphatic-cells-by-ultrasound-technologies
#21
JOURNAL ARTICLE
Qionghua Shen, Zongru Li, Yixian Wang, Matthew D Meyer, Marc T De Guzman, Janie C Lim, Han Xiao, Richard R Bouchard, George J Lu
Ultrasound imaging and ultrasound-mediated gene and drug delivery are rapidly advancing diagnostic and therapeutic methods; however, their use is often limited by the need of microbubbles, which cannot transverse many biological barriers due to their large size. Here we introduce 50-nm gas-filled protein nanostructures derived from genetically engineered gas vesicles that we referred to as 50nm GVs. These diamond-shaped nanostructures have hydrodynamic diameters smaller than commercially available 50-nm gold nanoparticles and are, to our knowledge, the smallest stable, free-floating bubbles made to date...
March 27, 2024: Advanced Materials
https://read.qxmd.com/read/38533876/lymph-node-targeting-mediated-by-albumin-hitchhiking-of-synthetic-tn-glycolipid-leads-to-robust-in-vivo-antibody-production
#22
JOURNAL ARTICLE
Keerthana Thekke Veettil, Narayanaswamy Jayaraman
Tn antigen is a tumor-associated carbohydrate antigen (TACA), which is present prominently on the tumor cell surfaces and attracts an interest in the vaccine development. In this work, we demonstrate that a synthetic Tn antigen carrying glycoconjugate forms complex with circulating albumin, delivers the antigen to lymph nodes and leads to efficient production of antibody against the antigen. Synthetic Tn antigen glycoconjugate, possessing DSPE-PEG2000 linker and lipophilic moieties, undergoes micellization in PBS buffer...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38533519/the-extended-chest-wall-perforator-flap-expanding-the-indication-for-partial-breast-reconstruction
#23
JOURNAL ARTICLE
Adeline C Rankin, Hend Almalki, Bahar Mirshekar-Syahkal, Maged I Hussien
BACKGROUND: The intercostal artery perforator flap has traditionally been used to reconstruct small or moderate-sized single defects in the lateral or lower medial breast during breast-conserving surgery. We report a modification of the intercostal artery perforator flap that allows for reconstruction of larger breast tumors than previously described flap designs. METHODS: A retrospective study of breast cancer patients undergoing breast-conserving surgery and immediate partial breast reconstruction with an extended chest wall perforator flap...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38533512/exploring-the-clinical-significance-of-il-38-correlation-with-pd-1-ctla-4-and-foxp3-in-colorectal-cancer-draining-lymph-nodes
#24
JOURNAL ARTICLE
Liuhong Yuan, Zhenyu Tan, Junjie Huang, Feier Chen, Brett D Hambly, Shisan Bao, Kun Tao
INTRODUCTION: Colorectal cancer (CRC) presents a substantial challenge characterized by unacceptably high mortality and morbidity, primarily attributed to delayed diagnosis and reliance on palliative care. The immune response of the host plays a pivotal role in carcinogenesis, with IL-38 emerging as a potential protective factor in CRC. However, the precise involvement of IL-38 among various leucocytes, its interactions with PD-1/PD-L1, and its impact on metastasis require further elucidation...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533387/talaromycosis-from-wuhan-two-case-report-and-literature-review
#25
Zhiyuan Yao, Zhou Pan, Guang Li, Zhaomin Liao, Zhen Yu, Liying Zhan, Wenfang Xia
BACKGROUND: Talaromycosis is a serious opportunistic infectious disease caused by Talaromyces marneffei , which mostly occurs in immunocompromised patients. The disease is mainly prevalent in tropical countries and regions of Southeast Asia and South Asia, but non-endemic areas also have patients with Talaromycosis. The disease has no characteristic clinical manifestations and is difficult to diagnose. Delayed diagnosis often leads to death. CASE PRESENTATION: Both patients had cellular immunodeficiency...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38533264/korean-red-ginseng-extract-prevents-bone-loss-in-an-oral-model-of-glucocorticoid-induced-osteoporosis-in-mice
#26
JOURNAL ARTICLE
Nicholas J Chargo, Ho Jun Kang, Subhashari Das, Yining Jin, Cheryl Rockwell, Jae Youl Cho, Laura R McCabe, Narayanan Parameswaran
The gut microbiota and barrier function play important roles in bone health. We previously demonstrated that chronic glucocorticoid (GC)-induced bone loss in mice is associated with significant shifts in gut microbiota composition and impaired gut barrier function. Korean Red Ginseng (KRG, Panax Ginseng Meyer, Araliaceae) extract has been shown to prevent glucocorticoid-induced osteoporosis (GIO) in a subcutaneous pellet model in mice, but its effect on gut microbiota and barrier function in this context is not known...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533057/lrrc59-promotes-the-progression-of-oral-squamous-cell-carcinoma-by-interacting-with-srp-pathway-components-and-enhancing-the-secretion-of-ckap4-containing-exosomes
#27
JOURNAL ARTICLE
Qijun Sun, Lili Jin, Shunli Dong, Ling Zhang
BACKGROUND: As a ribosome receptor, LRRC59 was thought to regulate mRNA translation on the ER membrane. Evidence suggests that LRRC59 is overexpressed in a number of human malignancies and is associated with poor prognoses, but its primary biological function in the development of oral squamous cell carcinoma (OSCC) remains obscure. OBJECTIVE: The purpose of this study is to investigate at the expression changes and functional role of LRRC59 in OSCC. METHODS: LRRC59 gene expression and correlation with prognosis of OSCC patients were first examined using the data from The Cancer Genome Atlas (TCGA) databases...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532592/-application-value-of-laparoscopic-double-stapler-firings-and-double-stapling-technique-combined-with-rectal-eversion-and-total-extra-abdominal-resection-in-the-sphincter-preserving-resection-of-low-rectal-cancer
#28
JOURNAL ARTICLE
H Liang, K Q Wu, Q W Fan, W Zheng, H Zhang, J W Bai, J M Li, J Q Chen, C Zhang
Objectives: To investigate the application value of laparoscopic double stapler firings and double stapling technique combined with rectal eversion and total extra-abdominal resection (LDER) in the anal preservation treatment of low rectal cancer. Methods: Inclusion criteria: (1) age was 18-70; (2) the distance of the lower tumor edge from the anal verge was 4-5 cm; (3) primary tumor with a diameter ≤3 cm; (4) preoperative staging of T1~2N1~2M0; (5) "difficult pelvis", defined as ischial tuberosity diameter<10 cm or body mass index>25 kg/m2 ; (6) patients with strong intention for sphincter preservation; (7) no preoperative treatment (e...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532588/-propensity-score-matching-analysis-of-the-short-term-efficacy-of-kamikawa-versus-double-tract-reconstruction-in-laparoscopic-proximal-gastric-cancer-surgery
#29
JOURNAL ARTICLE
H C Yang, J X He, Y Yang, Z Han, B Zhang, S Zhou, T Wu, Q Qiao, X L He, N Wang
Objective: To compare the short-term efficacy of Kamikawa anastomosis and double-tract reconstruction (DTR) after proximal gastrectomy. Methods: This was a propensity score matched, retrospective, cohort study. Inclusion criteria comprised age 20-70 years, diagnosis of gastric cancer by pathological examination of preoperative endoscopic biopsies, tumor diameter ≤4 cm, and location in the upper 1/3 of the stomach (including the gastroesophageal junction), and TNM stage IA, IB, or IIA. The study cohort comprised 73 patients who had undergone laparoscopic proximal gastric cancer radical surgery in the Department of Gastroenterology, Tangdu Hospital, Air Force Medical University between June 2020 and February 2023, 19 of whom were in the Kamikawa group and 54 in the DTR group...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532532/treatment-delay-and-hpv-status-on-opscc-with-upfront-surgery-analysis-of-national-cancer-database
#30
JOURNAL ARTICLE
Milind Vasudev, Elaine Martin, Madelyn I Frank, Leo L T Meller, Yarah M Haidar
OBJECTIVE: Evaluate the effect of treatment delay on survival in human papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) patients undergoing primary surgical resection. STUDY DESIGN: Retrospective cohort study using the 2010-2017 National Cancer Database. SETTING: Multicenter database study. METHODS: Patients >18 years old with OPSCC and known HPV status, treated surgically with or without postoperative radiation/chemotherapy were included...
March 26, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38532506/sonographic-characteristics-of-diffuse-sclerosing-variant-of-papillary-thyroid-carcinoma-with-histopathological-correlation-a-preliminary-study
#31
JOURNAL ARTICLE
Wanying Li, Ying Wang, Luying Gao, Ruie Feng, Ke Lv, Xining Wu, Xiao Yang, Sheng Cai, Hongyan Wang, Jianchu Li
BACKGROUND: Diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) is a rare but high invasive subtype of papillary thyroid carcinoma, which mandates an aggressive clinical strategy. Few studies have focused on the sonographic characteristics of DSVPTC and the role of ultrasound in diagnosis and treatment of this variant remains unknown. This study aimed to identify and understand DSVPTC more accurately under ultrasound in correlation with pathology. METHODS: The ultrasound characteristics and histopathologic sections of 10 lesions in 10 DSVPTC patients who underwent thyroid surgery at our center between 2014 and 2020 were reviewed and compared with 184 lesions in 168 classic variant of papillary thyroid carcinoma (cPTC) patients...
March 26, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38532442/facial-cutaneous-rosai-dorfman-disease-a%C3%A2-case-report
#32
JOURNAL ARTICLE
Tanapong Wongrat, Siripan Sangmala
BACKGROUND: Rosai-Dorfman disease (RDD) is a form of non-Langerhans cell histiocytosis in which the activated histiocytes of the lymph nodes and other organs begin to accumulate following excessive production. Bilateral, massive, and painless lymphadenopathy are classic presentations. Systemic RDD is already known to be a rare condition, but isolated cutaneous RDD is extremely rare. We presented a rare and unusual presentations of a disease. CASE PRESENTATION: A 35-year-old Thai female with a 6-month history of a small acne-like lesion that rapidly progressed to 5 cm tumor-like lesions on the face within 3 months...
March 27, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38532426/mir-101-3p-mediated-role-of-pdzk1-in-hepatocellular-carcinoma-progression-and-the-underlying-pi3k-akt-signaling-mechanism
#33
JOURNAL ARTICLE
Huihui Gao, Zhaofeng Gao, Xiaobei Liu, Xu Sun, Zhonghui Hu, Zhengwei Song, Cheng Zhang, Jianguo Fei, Xiaoguang Wang
BACKGROUND: The molecular targets and associated mechanisms of hepatocellular carcinoma (HCC) have been widely studied, but the roles of PDZK1 in HCC are unclear. Therefore, the aim of this study is to explore the role and associated mechanisms of PDZK1 in HCC. RESULTS: It was found that the expression of PDZK1 in HCC tissues was higher than that in paired paracancerous tissues. High expression of PDZK1 was associated with lymph node metastasis, degree of differentiation, and clinical stage...
March 26, 2024: Cell Division
https://read.qxmd.com/read/38532371/minimally-invasive-cytoreductive-radical-prostatectomy-exploring-the-safety-and-feasibility-of-a-single-port-or-multi-port-robotic-platform
#34
JOURNAL ARTICLE
Daniel J Lama, Kyle Thomas, Simone L Vernez, Oluwatimilehin Okunowo, Clayton S Lau, Bertram E Yuh
BACKGROUND: Consolidative resection or cytoreductive radical prostatectomy (CRP) may benefit men with non-organ confined prostate cancer. We report the safety, feasibility, and outcomes of robot-assisted laparoscopic CRP using a single-port (SP) or multi-port (MP) platform. METHODS: We reviewed consecutive men with clinical node positive or metastatic castrate-sensitive prostate cancer who underwent IRB-approved CRP and extended pelvic lymph node dissection using the da Vinci SP or MP Surgical Systems (Intuitive Surgical, Sunnyvale, CA) from 2015-2022...
March 26, 2024: BMC Urology
https://read.qxmd.com/read/38532203/topical-application-of-ozonated-sunflower-oil-accelerates-the-healing-of-lesions-of-cutaneous-leishmaniasis-in-mice-under-meglumine-antimoniate-treatment
#35
JOURNAL ARTICLE
Ana Paula Pivotto, Lucas Bonatto de Souza Lima, Alexandra Michelon, Camilla Zottesso Pellon Ferreira, Rinaldo Ferreira Gandra, Thaís Soprani Ayala, Rafael Andrade Menolli
Besides being scarce, the drugs available for treating cutaneous leishmaniasis have many adverse effects. Ozone is an option to enhance the standard treatment due to the wound-healing activity reported in the literature. In this study, we evaluated the efficiency of ozonated sunflower oil as an adjuvant in treating cutaneous lesions caused by Leishmania amazonensis. BALB/c mice were infected with L. amazonensis, and after the lesions appeared, they were treated in four different schedules using the drug treatment with meglumine antimoniate (Glucantime®), with or without ozonated oil...
March 27, 2024: Medical Microbiology and Immunology
https://read.qxmd.com/read/38532076/follicular-dendritic-cell-sarcoma-arising-from-the-lymph-node-of-the-pancreatic-head-a-case-report-with-literature-review
#36
JOURNAL ARTICLE
Takahiro Yamada, Keinosuke Ishido, Norihisa Kimura, Taiichi Wakiya, Hayato Nagase, Shintaro Goto, Tadashi Yoshizawa, Hiroshi Kijima, Seiichi Kato, Kenichi Hakamada
A 72-year-old man was referred to our hospital for the examination of a pancreatic head mass. Abdominal computed tomography revealed a contrasted 8-cm-diameter tumor extending from the dorsal pancreatic head to the porta hepatis. The preoperative diagnosis was challenging due to the absence of specific imaging findings and the inability to perform a biopsy. Positron emission tomography/computed tomography and diffusion-weighted imaging suggested a malignant tumor originating from the organs surrounding the pancreatic head...
March 26, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38532026/macrophage-mannose-receptor-cd206-targeting-of-fluoride-18-labeled-mannosylated-dextran-a-validation-study-in-mice
#37
JOURNAL ARTICLE
Putri Andriana, Ruth Fair-Mäkelä, Heidi Liljenbäck, Salli Kärnä, Imran Iqbal, Konstantina Makrypidi, Johan Rajander, Ioannis Pirmettis, Xiang-Guo Li, Sirpa Jalkanen, Antti Saraste, Marko Salmi, Anne Roivainen
PURPOSE: Aluminum fluoride-18-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated mannosylated dextran derivative (Al[18 F]F-NOTA-D10CM) is a new tracer for PET imaging. We report here on in vitro and in vivo validation of the tracer's ability to target the macrophage mannose receptor CD206. METHODS: First, the uptake of intravenously (i.v.) administered Al[18 F]F-NOTA-D10CM was compared between wild-type (WT) and CD206-/- knockout (KO) mice. C57BL/6N mice were injected with complete Freund's adjuvant (CFA) in the left hind leg and the uptake of Al[18 F]F-NOTA-D10CM after i...
March 27, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38531804/investigating-the-spatial-distribution-of-proliferating-cells-in-primary-ovarian-cancers
#38
JOURNAL ARTICLE
Mohamed A A A Hegazi, Fabio Pasqualini, Gianluigi Taverna, Robert S Bresalier, Maurizio Chiriva-Internati, Fabio Grizzi
BACKGROUND: Ovarian cancer (OC) accounts for about 4% of female cancers globally. While Ki67-immunopositive (Ki67+ ) cell density is commonly used to assess proliferation in OC, the two-dimensional (2D) distribution pattern of these cells is poorly understood. This study explores the 2D distribution pattern of Ki67+ cells in primary OC tissues and models the proliferation process to improve our understanding of this hallmark of cancer. METHODS: A total of 100 tissue cores, included in a tissue microarray (TMA) representing 5 clear cell carcinomas, 62 serous carcinomas, 10 mucinous adenocarcinomas, 3 endometrioid adenocarcinomas, 10 lymph node metastases from OC, and 10 samples of adjacent normal ovary tissue, were stained using a standardized immunohistochemical protocol...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531796/dna-methylation-regulated-hoxc8-s-role-in-her2-positive-breast-cancer-function-and-its-contribution-to-herceptin-resistance
#39
JOURNAL ARTICLE
Xiaofeng Xie, Sijia Tang, Zhengyang Yu
BACKGROUND: The epidermal growth factor receptor 2 ( HER2 ) is overexpressed in 30% of breast cancers, and this overexpression is strongly correlated with a poor prognosis. Herceptin is a common treatment for HER2-positive breast cancer; however, cancer cells tend to adapt gradually to the drug, rendering it ineffective. The study revealed an association between the methylation status of the Homeobox C8 ( HOXC8 ) gene and tumor development. Therefore, it is of paramount importance to delve into the interaction between HOXC8 and HER2-positive breast cancer, along with its molecular mechanisms...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531735/fluorescence-guided-thoracoscopic-surgery-for-postoperative-chylothorax-a-technical-note-with-video-vignette
#40
JOURNAL ARTICLE
Tzu-Wei Kuo, Shih-Kang Tseng, Pin-Li Chou, Chuan Cheng, Sung-Yu Chu, Yin-Kai Chao
TECHNIQUE: The surgical management for high-output postoperative chylothorax typically necessitates ligation of the thoracic duct (TD) above the leak site and/or sealing the leak with a clip. However, pinpointing these structures during subsequent surgeries can be challenging due to their variable course and the presence of traumatized tissues surrounding the leak area. In response to this, we have developed a novel, fluorescence-guided technique that significantly enhances intraoperative identification of the leak point and the TD...
March 25, 2024: Asian Journal of Surgery
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