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https://www.readbyqxmd.com/read/29356201/novel-method-to-save-the-parathyroid-gland-during-thyroidectomy-subcapsular-saline-injection
#1
June Young Choi, Hyeong Won Yu, In Eui Bae, Jong-Kyu Kim, Chan Yong Seong, Jin Wook Yi, Young Jun Chai, Su-Jin Kim, Kyu Eun Lee
BACKGROUND: Saving the parathyroid gland during thyroidectomy remains challenging. Subcapsular saline injection (SCASI) was developed in February 2015. Its ability to spare the parathyroid gland was assessed. METHODS: All consecutive patients who underwent total thyroidectomy with or without neck lymph node dissection in 2013-2015 were included in this retrospective cohort study. Patients were divided into the SCASI and non-SCASI groups. Serum parathyroid hormone (PTH) levels were measured on day 1 and 6 months after surgery...
January 22, 2018: Head & Neck
https://www.readbyqxmd.com/read/29355996/lymphatic-vessel-diameter-in-female-pelvic-cancer-related-lower-extremity-lymphedematous-limbs
#2
Takumi Yamamoto, Mitsunaga Narushima, Isao Koshima
BACKGROUND: Lymphaticovenular anastomosis (LVA) has become one of the useful surgical treatments for compression-refractory lower extremity lymphedema (LEL). It is important to anastomose larger lymphatic vessels with abundant lymph flows in LVA surgery. This study aimed to clarify factors associated with lymphatic vessel diameter. METHODS: One hundred thirty-four LEL patients who underwent pre-operative indocyanine green (ICG) lymphography and LVA from June 2009 to August 2014 in a single institution were included in this retrospective observational study...
January 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29355987/staged-surgical-treatment-of-extremity-lymphedema-with-dual-gastroepiploic-vascularized-lymph-node-transfers-followed-by-suction-assisted-lipectomy-a-prospective-study
#3
Mouchammed Agko, Pedro Ciudad, Hung-Chi Chen
BACKGROUND: Both physiologic and excisional procedures have been described for the treatment of lymphedema. However, there exist few reports that combine these procedures. The objective of this study was to evaluate the effectiveness of combining vascularized lymph node transfer (VLNT) with suction-assisted lipectomy (SAL) in a staged manner for the treatment of extremity lymphedema. METHODS: Patients with unilateral late stage II lymphedema (International Society of Lymphology), who consented to staged surgical treatment, were evaluated prospectively...
January 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29355962/alternative-vascular-constructs-of-lymph-node-flap-transfer
#4
Fabio Nicoli, Georgios Orfaniotis, Pedro Ciudad, Kidakorn Kiranantawat, Davide Lazzeri, Michele Maruccia, Joannis Constantinides, Bulent Sacak, Ram M Chilgar, Ke Li, Yi Xin Zhang, Hung-Chi Chen
Vascularized lymph node transfer is a quite innovative physiological surgical procedure for the lymphedema treatment. Although is gaining more popularity due to its promising results, there are some concerns regarding difficult to harvest it and the potential risk of iatrogenic lymphedema. Here, we present alternative vascular constructs of lymph node flap for the treatment of lymphedema, which provide the benefits of a technically easier dissection and physiological reconstruction of the damaged lymphatics...
January 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29355840/long-noncoding-rna-blacat2-promotes-bladder-cancer-associated-lymphangiogenesis-and-lymphatic-metastasis
#5
Wang He, Guangzheng Zhong, Ning Jiang, Bo Wang, Xinxiang Fan, Changhao Chen, Xu Chen, Jian Huang, Tianxin Lin
The prognosis for bladder cancer patients with lymph node (LN) metastasis is dismal and only minimally improved by current treatment modalities. Elucidation of the molecular mechanisms that underlie LN metastasis may provide clinical therapeutic strategies for LN-metastatic bladder cancer. Here, we report that a long noncoding RNA LINC00958, which we have termed bladder cancer-associated transcript 2 (BLACAT2), was markedly upregulated in LN-metastatic bladder cancer and correlated with LN metastasis. Overexpression of BLACAT2 promoted bladder cancer-associated lymphangiogenesis and lymphatic metastasis in both cultured bladder cancer cell lines and mouse models...
January 22, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29355615/a-competing-risk-model-of-first-failure-site-after-definitive-chemo-radiation-therapy-for-locally-advanced-non-small-cell-lung-cancer
#6
Lotte Nygård, Ivan R Vogelius, Barbara M Fischer, Andreas Kjær, Seppo W Langer, Marianne Aznar, Gitte F Persson, Søren M Bentzen
INTRODUCTION: The aim of the study was to build a model of first failure site and lesion specific failure probability after definitive chemo-radiotherapy for inoperable non-small cell lung cancer (NSCLC). METHODS: We retrospectively analyzed 251 patients receiving definitive chemo/radiotherapy for NSCLC at a single institution between 2009-2015. All patients were FDG PET/CT scanned for radiotherapy planning. Clinical patient data and FDG PET standardized uptake values from primary tumor and nodal lesions were analyzed using multivariate cause-specific Cox regression...
January 18, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29355613/histopathological-growth-patterns-as-a-candidate-biomarker-for-immunomodulatory-therapy
#7
REVIEW
Pieter-Jan van Dam, Sofie Daelemans, Elizabeth Ross, Yannick Waumans, Steven Van Laere, Emily Latacz, Roanne Van Steen, Christel De Pooter, Mark Kockx, Luc Dirix, Peter B Vermeulen
The encroachment of a growing tumor upon the cells and structures of surrounding normal tissue results in a series of histopathological growth patterns (HGPs). These morphological changes can be assessed in hematoxylin-and-eosin (H&E) stained tissue sections from primary and metastatic tumors and have been characterized in a range of tissue types including liver, lung, lymph node and skin. HGPs in different tissues share certain general characteristics like the extent of angiogenesis, but also appropriate tissue-specific mechanisms which ultimately determine differences in the biology of HGP subtypes...
January 17, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29355487/mesothelioma-with-a-large-prevascular-lymph-node-n1-involvement-or-something-different
#8
Lawek Berzenji, Paul E Van Schil, Annemie Snoeckx, Marjan Hertoghs, Laurens Carp
A 64-year-old man presented with a large amount of right-sided pleural fluid upon imaging, together with calcified pleural plaques and an enlarged nodular structure in the prevascular mediastinum, presumably an enlarged lymph node. Pleural biopsies were obtained during video-assisted thoracoscopic surgery to exclude malignancy. Histopathology showed an epithelial malignant pleural mesothelioma. Induction chemotherapy with cisplatin/pemetrexed was administered followed by an extended pleurectomy/decortication with systematic nodal dissection...
January 18, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29354905/-advancement-of-minimally-invasive-esophagectomy
#9
Yue Zhao, Yousheng Mao
Esophageal cancer is one of the most common malignant digestive system cancers in China, which has high incidence and mortality. Nowadays, surgery remains the most important part of the comprehensive treatments. Conventional open esophagectomies are highly traumatic with high morbidity, while minimally invasive esophagectomy has been increasingly used with the development of surgical instruments and techniques in recent years. Compared with conventional open esophagectomy(OE), what are the advantages of minimally invasive esophagectomy (MIE) and which is preferable? This review briefly introduces the developing history of MIE and common procedures...
January 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29354903/-the-value-of-mri-with-cube-sequence-in-early-evaluation-of-the-efficacy-of-neoadjuvant-therapy-for-locally-advanced-rectal-cancer
#10
Xinhua Wang, Wuteng Cao, Dechao Liu, Fangqian Li, Wenli Li, Liang Kang, Yanhong Deng, Zhiyang Zhou
OBJECTIVE: To investigate the value of MRI with CUBE sequence in early evaluation of the efficacy of neoadjuvant therapy (NAT) for locally advanced rectal cancer. METHODS: Inclusion criteria: (1) rectal cancer proven by biopsy; (2) locally advanced rectal cancer (T3-4 or positive lymph nodes) with distance from lower edge of tumor to anal verge within 12 cm diagnosed by MRI before NAT; (3) acceptance of NAT treatment regulations and completion of NAT; (4) completion of routine MRI scan and CUBE scan before and after 2-course NAT chemotherapy (including new neoadjuvant chemotherapy and chemoradiotherapy); (5) completion of surgery 6-8 weeks after NAT; (6) exclusion of any previous NAT due to rectal malignant tumor or other tumors; (7) exclusion of poor image quality of preoperative routine MRI insufficient for rectal cancer staging or of CUBE image insufficient for tumor volume measurement...
January 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29354900/-analysis-of-risk-factor-of-perioperative-complications-in-patients-with-radical-gastrectomy-for-gastric-cancer-and-its-influence-on-prognosis
#11
Junrui Jin, Jingyu Deng, Han Liang, Changyu Sun, Xiaofan Guo, Jiangtao Guo, Huihui Bai, Huifang Liu, Nannan Zhang
OBJECTIVE: To study the risk factor of perioperative complication in gastric cancer patients with radical therapy and its influence on prognosis. METHODS: Clinical, pathological and follow-up data of 1 148 gastric cancer patients undergoing radical gastrectomy at Tianjin Medical University Affiliated Tumor Hospital between January 2009 and August 2011 were retrospectively collected. Pearson 2 test and Logistic regression analysis were used to analyze the risk factor of perioperative complication...
January 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29354899/-accurate-low-ligation-of-inferior-mesenteric-artery-and-root-lymph-node-dissection-according-to-different-vascular-typing-in-laparoscopic-radical-resection-of-rectal-cancer
#12
Jiaming Zhou, Shuyun Zhang, Jun Huang, Pinzhu Huang, Shaoyong Peng, Jinxin Lin, Tuoyang Li, Jianping Wang, Meijin Huang
OBJECTIVE: To explore the feasibility and clinical significance of precision low inferior mesenteric artery (IMA) ligation with the left colonic artery (LCA) preservation and root lymph node dissection in laparoscopic radical resection for rectal cancer, according to the inferior mesenteric artery (IMA) types. METHODS: One Hundred and fore cases of rectal cancer patients who underwent laparoscopic resection in The Sixth Affiliated Hospital of Sun Yat-sen University from October 2015 to June 2016 were selected and divided into study group and control group according to different surgical methods...
January 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29354891/-2107-hotspots-review-and-future-prospects-in-colorectal-cancer
#13
Jianping Wang
Radical surgeries and(neo) adjuvant therapies have significantly prolonged survival of patients with colorectal cancer. Microinvasive surgery and function preservation become more important with the prerequisite of R0 resection. As for colorectal cancer, long term survival after laparoscopic curative surgery is proved non-inferior to its open counterpart. The new transanal approach of total mesorectal excision, while avoiding abdominal incision for extraction, may as well improve surgical quality. Local excision and the "watch and wait" strategy, though attractive for organ-preservation, are undermined by suboptimal clinical and radiographic assessment of lymph node and treatment response, respectively...
January 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29354608/a-granular-cell-tumor-of-the-rectum-a-case-report-and-review-of-the-literature
#14
Seung Yoon Yang, Byung Soh Min, Woo Ram Kim
A granular cell tumor (GCT) is an uncommon mesenchymal lesion that rarely occurs in the colon and the rectum. We describe the case of 51-year-old man with a 2-cm-sized rectal GCT 10 cm above the anal verge that was incidentally detected after a screening colonoscopy. Preoperative radiologic studies demonstrated a suspicious submucosal rectal mass with mesorectal fat infiltration, but without circumferential resection margin threatening, extramural vessel invasion, and regional lymph-node enlargement. The tumor was resected by using a transanal endoscopic operation (TEO) without immediate postoperative complications...
December 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/29354603/is-the-location-of-the-tumor-another-prognostic-factor-for-patients-with-colon-cancer
#15
Myung-Kyu Jung, Ui Sup Shin, Young-Jun Ki, Yong-Bae Kim, Sun-Mi Moon, Se-Jin Sung
Purpose: In this study, we investigated both the characteristics of right colon cancer (RTCC) in comparison with those of left colon cancer (LTCC) and the impact of the location of the colon cancer on the prognosis. Methods: We retrospectively analyzed the cases of 974 patients with nonmetastatic colon cancer who had undergone surgery with a curative intent from January 2001 to December 2011. RTCC was defined as a tumor located proximal to the splenic flexure. The characteristics of RTCC cancer were investigated by using descriptive analyses, and their impacts on the prognosis were assessed by using a Cox multivariate regression...
December 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/29354584/quantitative-lymphoscintigraphy-to-predict-the-possibility-of-lymphedema-development-after-breast-cancer-surgery-retrospective-clinical-study
#16
Paul Kim, Ju Kang Lee, Oh Kyung Lim, Heung Kyu Park, Ki Deok Park
Objective: To predict the probability of lymphedema development in breast cancer patients in the early post-operation stage, we investigated the ability of quantitative lymphoscintigraphic assessment. Methods: This retrospective study included 201 patients without lymphedema after unilateral breast cancer surgery. Lymphoscintigraphy was performed between 4 and 8 weeks after surgery to evaluate the lymphatic system in the early postoperative stage. Quantitative lymphoscintigraphy was performed using four methods: ratio of radiopharmaceutical clearance rate of the affected to normal hand; ratio of radioactivity of the affected to normal hand; ratio of radiopharmaceutical uptake rate of the affected to normal axilla (RUA); and ratio of radioactivity of the affected to normal axilla (RRA)...
December 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29353973/prognostic-evaluation-of-postoperative-adjuvant-therapy-for-operable-cervical-cancer-10-years-experience-of-national-cancer-center-in-china
#17
Tong Shu, Dan Zhao, Bin Li, Yating Wang, Shuanghuan Liu, Pingping Li, Jing Zuo, Ping Bai, Rong Zhang, Lingying Wu
Objective: The aim of this study was to investigate the prognostic factors and to evaluate the impact of adjuvant therapy on clinical outcome for early-stage cervical cancer. Methods: The clinical-pathological data of all 1,335 patients with the International Federation of Gynecology and Obstetrics (FIGO) Ib-IIa cervical cancer treated with primary radical surgery at the Chinese National Cancer Center between May 2007 and Dec 2013 were retrospectively reviewed. The median follow-up was 70 months...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353366/is-invasion-a-necessary-step-for-metastases-in-breast-cancer
#18
REVIEW
Steven A Narod, Victoria Sopik
PURPOSE: To review the empirical evidence to support the conventional (sequential) model of breast cancer progression, which is based on the paradigm that cancer passes through several stages, including an in situ stage prior to an invasive stage, and thereafter (in some cases) disseminates to the lymph nodes and distant organs. METHODS: We review the cancer literature of the last 50 years which relates to the prevention of invasive breast cancer (through radiotherapy or surgery) and reductions in the mortality for breast cancer...
January 20, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29353314/robot-assisted-post-chemotherapy-retroperitoneal-lymph-node-dissection-in-germ-cell-tumor-is-the-single-docking-with-lateral-approach-relevant
#19
C Overs, J B Beauval, L Mourey, P Rischmann, M Soulié, M Roumiguié, Nicolas Doumerc
INTRODUCTION: Surgical treatment of post-chemotherapy residual mass of germ cell tumor (GCT) may be performed in various techniques. We assess the feasibility, safety, and efficacy of single-docking with lateral approach robot-assisted retroperitoneal lymph node dissection (R-RPLND) in residual mass of GCT in our center. MATERIALS AND METHODS: A retrospective review of patients undergoing R-RPLND for residual mass of CGT was performed between January 2014 and April 2017...
January 20, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29352742/cambogin-suppresses-dextran-sulphate-sodium-induced-colitis-by-enhancing-treg-cell-stability-and-function
#20
Yue Lu, Na-Mi Kim, Yi-Wen Jiang, Hong Zhang, Dan Zheng, Fu-Xiang Zhu, Rui Liang, Bin Li, Hong-Xi Xu
BACKGROUND AND PURPOSE: Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of gastrointestinal tract, and the dysfunction of immune regulation plays a critical role in IBD. Reflecting the limited use of current drugs and therapies for IBD treatment, it is necessary to explore novel drugs or therapies for this disease. We investigated the effect of cambogin in a mouse model of dextran sulphate sodium (DSS)-induced colitis and whether cambogin attenuates inflammation via Treg-cell-mediated immune modulation...
January 20, 2018: British Journal of Pharmacology
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