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https://www.readbyqxmd.com/read/28110490/high-expression-of-wls-is-associated-with-lymph-node-metastasis-and-advanced-tnm-stage-in-gastric-carcinomas
#1
Wei Zhang, Hong Tao, Xiao Chen, Haruhiko Sugimura, Jiandong Wang, Ping Zhou
The roles of Wnt protein in carcinogenesis have been well documented in human cancers. Wls is a key modulator for the secretion of Wnt protein. We previously found that Wls was aberrantly expressed in colorectal carcinomas. Studies have revealed that dysregulation of Wnt signal transduction plays an important role in gastric carcinoma. We hypothesized that Wls may play a role in the development and progression of gastric carcinoma. In this study, three gastric cancer cell lines MGC-803, SGC-7901, and AGS, and a set of gastric carcinoma tissue specimens were subjected to immunohistochemistry...
January 22, 2017: Pathology International
https://www.readbyqxmd.com/read/28110435/comparison-between-solid-component-size-on-thin-section-ct-and-pathologic-lymph-node-metastasis-and-local-invasion-in-t1-lung-adenocarcinoma
#2
Hideyuki Hayashi, Kazuto Ashizawa, Yukihiro Ogihara, Akifumi Nishida, Keitaro Matsumoto, Naoya Yamasaki, Takeshi Nagayasu, Minoru Fukuda, Sumihisa Honda, Masataka Uetani
OBJECTIVES: To correlate the tumor size and solid component size on thin-section CT (TS-CT) with pathological findings including lymph node (LN) metastasis and local invasion in T1 lung adenocarcinoma. METHODS: 188 patients with surgically resected T1 lung adenocarcinoma were retrospectively analyzed. Two chest radiologists measured the long-axis and short-axis dimensions of nodules and solid components with a lung and/or a mediastinal window setting (WS) on TS-CT...
January 21, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28110398/simultaneous-robotic-subtotal-gastrectomy-and-right-hemicolectomy-for-synchronous-adenocarcinoma-of-stomach-and-colon
#3
Byoung Jo Suh, Sung Jin Oh, Jin Yong Shin, Do Hoon Ku, Dong Sik Bae, Jong Kwon Park
Simultaneous laparoscopy-assisted resection for synchronous stomach and colon cancers has been reported frequently; however, robot-assisted gastrectomy and colectomy for these conditions are rarely reported. We report the successful use of robotic surgery for synchronous cancers of the stomach and colon. A 71-year-old woman with no specific medical history was diagnosed with early gastric cancer at the gastric angle and right colon cancer after undergoing esophagogastroduodenoscopy and colonofiberoscopy. Abdomino-pelvic computed tomography revealed that the stomach and colon lesions were limited to the mucosa without any lymph nodes or distant metastasis, which suggested the clinical stage for both cancers as T1N0M0...
January 21, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28110330/prognostic-advantage-of-docetaxel-cisplatin-5-fluorouracil-neoadjuvant-chemotherapy-in-clinical-stage-ii-iii-esophageal-squamous-cell-carcinoma-due-to-excellent-control-of-preoperative-disease-and-postoperative-lymph-node-recurrence
#4
Keishi Yamashita, Kei Hosoda, Hiromitsu Moriya, Chikatoshi Katada, Mitsuhiro Sugawara, Hiroaki Mieno, Shoko Komori, Natsuya Katada, Masahiko Watanabe
BACKGROUND: Neoadjuvant chemotherapy (NAC) has become prevalent in esophageal squamous cell carcinoma (ESCC), but its long-term prognostic advantages remain unclear. The latest prognostic outcomes in clinical Stage (cStage) II/III ESCC with NAC were herein elucidated. PATIENTS AND METHODS: NAC prior to curative treatment was done in 115 cStage II/III ESCC patients with either cisplatin (CDDP)/5-fluorouracil (5-FU; CF) (n = 41) or docetaxel/CDDP/5-FU (DCF) NAC (n = 74) between 2007 and 2013...
January 21, 2017: Oncology
https://www.readbyqxmd.com/read/28110206/an-epstein-barr-virus-susceptible-immature-t-cell-line-will4-established-from-a-patient-with-t-lymphoblastic-lymphoma-bearing-cd21-and-a-clonal-ebv-genome
#5
Hiroki Hosoi, Ken-Ichi Imadome, Shinobu Tamura, Kodai Kuriyama, Shogo Murata, Yusuke Yamashita, Toshiki Mushino, Takehiro Oiwa, Hiroshi Kobata, Akinori Nishikawa, Hideki Nakakuma, Nobuyoshi Hanaoka, Yasushi Isobe, Kouichi Ohshima, Takashi Sonoki
We managed a patient with an Epstein-Barr virus-associated T-cell lymphoblastic lymphoma. Mediastinal tumor cells at initial admission were positive for CD4, CD8, and TdT. Interestingly, a lymph node at necropsy was compatible for a CD4-positive peripheral T-cell lymphoma without CD8 and TdT expression, suggesting a different phenotype from the mediastinal tumor. Tumor cells in pleural effusion continued to proliferate in in vitro and were designated as WILL4. WILL4 cells were positive for CD3, CD4, CD8, CD21, T-cell receptor (TcR) αβ, and TdT, indicating a similar phenotype to thymocytes...
January 15, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28110170/tailoring-polymeric-hybrid-micelles-with-lymph-node-targeting-ability-to-improve-the-potency-of-cancer-vaccines
#6
Qin Zeng, Hanmei Li, Hao Jiang, Jiao Yu, Ying Wang, Huan Ke, Tao Gong, Zhirong Zhang, Xun Sun
It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines and particles sized between 10 and 100 nm with a neutral or negative surface charge are preferred for lymphatic transfer after subcutaneous or intradermal injection. However their limited uptake by antigen presenting cells (APCs) and inadequate retention within LNs undoubtedly restrains their strength on activating T cell immunity. Here, we address this issue by tailoring the physicochemical properties of polymeric hybrid micelles (HMs), which are self-assembled from two amphiphilic diblock copolymers, poly-(ethylene glycol) phosphorethanolamine (PEG-PE) and polyethylenimine-stearic acid conjugate (PSA) via hydrophobic and electrostatic interactions...
January 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28110027/vascular-resection-in-pancreaticoduodenectomy-for-periampullary-cancers-report-of-a-single-center-experience
#7
Mauro Podda, Jessica Thompson, Christoph Thomas Germain Kulli, Iain Stephen Tait
BACKGROUND: Pancreaticoduodenectomy (PD) is the only chance of cure for periampullary cancers. This study aims to evaluate survival and complication rates for PD with additional vascular resection performed for local vascular involvement and compare to standard PD. MATERIALS AND METHODS: A retrospective cohort analysis of a departmental hepato-pancreatobiliary database from 2004-2014 was performed. All patients (n=92) who underwent PD without vascular resection (n=72), with venous resection (n=16), with both arterial and venous resection (n=4) were included in the study...
January 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28109909/erk2-zeb1-mir-101-1-axis-contributes-to-epithelial-mesenchymal-transition-and-cell-migration-in-cancer
#8
Kailash Chandra Mangalhara, Siddharth Manvati, Sunil Kumar Saini, Kalaiarasan Ponnusamy, Gaurav Agarwal, Suresh K Abraham, Rameshwar N K Bamezai
Regulation of metastasis continues to remain enigmatic despite our improved understanding of cancer. Identification of microRNAs associated with metastasis in the recent past has provided a new hope. Here, we show how microRNA-101 (miR-101) regulates two independent processes of cellular metastasis by targeting pro-metastatic upstream regulatory transcription factors, ZEB1 and ZEB2, and downstream effector-actin modulators, RHOA and RAC1, providing a single target for therapeutic intervention. Further, we depict how down-regulation of miR-101 by extracellular signal-regulated kinase-2 (ERK2) is vital for MAP kinase pathway induced cellular migration and mesenchymal transition...
January 18, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28109842/reverse-transcriptase-loop-mediated-isothermal-amplification-for-the-detection-of-feline-coronavirus
#9
Angelica Stranieri, Stefania Lauzi, Alessia Giordano, Saverio Paltrinieri
The Feline coronavirus (FCoV) is the etiological agent of feline infectious peritonitis (FIP), a lethal disease of felids. The role of molecular methods is controversial for the diagnosis of FIP, while essential for the identification of the shedders. Thus, a fast and inexpensive method for the detection of FCoV could be beneficial, especially in multicat environments. A reverse transcription loop mediated isothermal amplification (RT-LAMP) assay was developed. RNA extraction and RT-nPCR for FCoV were performed on thirty-two samples (11 faeces, 9 blood, 8 effusions, and 4 lymph nodes) collected from 27 cats...
January 18, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28109818/identification-of-a-compound-isolated-from-german-chamomile-matricaria-chamomilla-with-dermal-sensitization-potential
#10
Cristina Avonto, Diego Rua, Pradeep B Lasonkar, Amar G Chittiboyina, Ikhlas A Khan
German chamomile is one of the most popular herbal ingredients used in cosmetics and personal care products. Allergic skin reactions following topical application of German chamomile have been occasionally reported, although it is not fully understood which of the chemical constituents is responsible for this adverse effect. In the present work, three candidate sensitizers were isolated from German chamomile based on activity-guided fractionation of chamomile extracts tested using the in vitro KeratinoSens™ assay...
January 18, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28109626/significance-of-lymph-node-metastasis-on-survival-of-women-with-uterine-adenosarcoma
#11
Hiroko Machida, Michael J Nathenson, Tsuyoshi Takiuchi, Crystal L Adams, Jocelyn Garcia-Sayre, Koji Matsuo
OBJECTIVE: Uterine adenosarcoma (UAS) is a rare gynecologic malignancy and the significance of lymph node metastasis on survival has not been well studied. METHODS: A retrospective study was performed utilizing the Surveillance, Epidemiology, End Results Program to examine UAS (n=994), endometrial stromal sarcoma (ESS, n=2910), and uterine leiomyosarcoma (LMS, n=5506) diagnosed between 1973 and 2013. The impact of lymph node metastasis on cause-specific survival (CSS) was cross-compared by multivariable analysis...
January 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28109575/nationwide-assessment-of-robotic-lobectomy-for-non-small-cell-lung-cancer
#12
Ravi Rajaram, Sanjay Mohanty, David J Bentrem, Emily S Pavey, David D Odell, Ankit Bharat, Karl Y Bilimoria, Malcolm M DeCamp
BACKGROUND: Robotic lobectomy has been described for non-small cell lung cancer (NSCLC). Our objectives were to (1) evaluate the use of robotic lobectomy over time, (2) identify factors associated with its use, and (3) assess outcomes after robotic lobectomy compared with other surgical approaches. METHODS: Stage I to IIIA NSCLC patients were identified from the National Cancer Data Base (2010 to 2012). Trends in robotic lobectomy were assessed over time, and multivariable logistic regression models were developed to identify factors associated with its use...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109572/subcarinal-lymph-nodes-should-be-dissected-in-all-lobectomies-for-non-small-cell-lung-cancer-regardless-of-primary-tumor-location
#13
Jens Eckardt, Erik Jakobsen, Peter B Licht
BACKGROUND: Mediastinal staging is of paramount importance for planning of treatment in non-small cell lung cancer (NSCLC). Single institution reports recently claimed that subcarinal lymph node dissection during resection of upper lobe NSCLC could be spared. We used a complete national lung cancer registry to investigate patterns of unsuspected mediastinal lymph node involvement after lobectomy. METHODS: During an 11-year period (2004 to 2014) 5,577 consecutive patients who underwent operations for NSCLC were investigated for unsuspected mediastinal lymph node involvement (N2 disease) discovered at final histopathology...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109569/adhering-to-quality-measures-in-esophagectomy-is-associated-with-improved-survival-in-all-stages-of-esophageal-cancer
#14
Pamela Samson, Varun Puri, Stephen Broderick, G Alexander Patterson, Bryan Meyers, Traves Crabtree
BACKGROUND: Quality measures for patients with early and locally advanced esophageal cancer undergoing esophagectomy have been made by national organizations. The rate of adherence to these measures as well as their association with overall survival are unknown. METHODS: Esophagectomy patients were abstracted from the National Cancer Database. Because neoadjuvant status was available since 2006, the analysis of locally advanced patients began at this time point...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109475/predictors-of-extracapsular-extension-in-hpv-associated-oropharyngeal-cancer-treated-surgically
#15
Mathew Geltzeiler, Daniel Clayburgh, John Gleysteen, Neil D Gross, Bronwyn Hamilton, Peter Andersen, Daniel Brickman
OBJECTIVES: Extracapsular extension (ECE) in cervical metastatic lymph nodes remains an indication for adding chemotherapy for patients with oropharyngeal squamous cell carcinoma (OPSCC). The aim of this study is to identify specific imaging characteristics on computed tomography (CT) scan that are predictive of ECE in order to better risk stratify patients preoperatively. MATERIALS AND METHODS: A single cohort study was performed using a prospectively collected database of patients with HPV-related OPSCC who underwent transoral robotic surgery with cervical lymphadenectomy...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109462/can-ratio-of-the-biggest-tumor-diameter-to-total-tumor-diameter-be-a-new-parameter-in-the-differential-diagnosis-of-agressive-and-favorable-multifocal-papillary-thyroid-microcarcinoma
#16
Abbas Ali Tam, Didem Özdemir, Neslihan Çuhacı, Hüsniye Başer, Ahmet Dirikoç, Cevdet Aydın, Aylin Kılıç Yazgan, Reyhan Ersoy, Bekir Çakır
OBJECTIVES: In this study, we aimed to evaluate the usefulness of a new parameter -ratio of the biggest tumor diameter to total tumor diameter- for the differentiation of agressive and favorable papillary thyroid microcarcinomas (PTMC). MATERIALS AND METHODS: The diameter of the biggest tumor focus was taken as the primary tumor diameter. Total tumor diameter was calculated as the sum of the maximal diameter of each lesion. Ratio of primary tumor diameter to total tumor diameter was defined as tumor diameter ratio (TDR)...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109407/treatment-of-the-axilla-in-patients-with-primary-breast-cancer-and-low-burden-axillary-disease-limitations-of-the-evidence-from-randomised-controlled-trials
#17
REVIEW
J F R Robertson, P J J Herrod, J Matthew, L S Kilburn, C E Coles, I Bradbury
Invasive breast cancer is the second most common cancer worldwide. It is known to metastasise to the regional axillary lymph nodes but there has been debate over what is the best way to stage and treat the axilla in patients presenting with primary breast cancer. Multiple trials over the last two decades have led to a change in practice from routine axillary lymph node dissection to sentinel lymph node biopsy in patients who are clinically lymph node negative preoperatively. This has resulted in new questions regarding subsequent treatment of some patients...
February 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28109398/evaluation-of-the-mediastinum-differentiating-between-stations-4l-5-and-6-using-ebus-and-eus
#18
Anna Bendzsak, Ricardo Oliveira, Eric Goudie, Vicky Thiffault, Adeline Jouquan, Pasquale Ferraro, Moishe Liberman
Correct identification of mediastinal lymph node stations with endoscopic ultrasound (EUS) and endobronchial ultrasound (EBUS) requires knowledge of their ultrasonic anatomical positions and relations. The ultrasonic positions of the lymph node stations located in and around the aortopulmonary window (stations 4L, 5, and 6) can be more challenging to understand. The aim of this report is to describe the endosonographic anatomic positions of stations 4L, 5, and 6 and to demonstrate their locations using EUS and EBUS...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109291/systemic-nocardiosis-in-a-dog-caused-by-nocardia-cyriacigeorgica
#19
Yesari Eroksuz, Nafia Canan Gursoy, Tolga Karapinar, Burak Karabulut, Canan Akdeniz Incili, Zeynep Yerlikaya, Zulal Asci Toraman, Mehmet Ozkan Timurkan, Hatice Eroksuz
BACKGROUND: Systemic nocardiosis due to Nocardia cyriacigeorgica has not been reported in dogs. CASE PRESENTATION: Light and electron microscopy, microbiological culture and molecular identification (PCR) were used to diagnose systemic nocardiosis caused by Nocardia cyriacigeorgica in a 3-month-old husky dog. The postmortem changes included multifocal to coalescing, sharply circumscribed pyogranulomatous inflammation and abscess formation in lungs, liver, myocardium, spleen, kidneys, brain, and hilar lymph nodes...
January 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28109288/long-intergenic-non-coding-rna-00152-promotes-lung-adenocarcinoma-proliferation-via-interacting-with-ezh2-and-repressing-il24-expression
#20
Qin-Nan Chen, Xin Chen, Zhen-Yao Chen, Feng-Qi Nie, Chen-Chen Wei, Hong-Wei Ma, Li Wan, Shuai Yan, Sheng-Nan Ren, Zhao-Xia Wang
BACKGROUND: Numerous studies have shown that long non-coding RNAs (lncRNAs) behave as a novel class of transcript during multiple cancer processes, such as cell proliferation, apoptosis, migration, and invasion. LINC00152 is located on chromosome 2p11.2, and has a transcript length of 828 nucleotides. The biological role of LINC00152 in LAD(lung adenocarcinoma) remains unknown. METHODS: Quantitative reverse transcription PCR(qRT-PCR) was used to detect LINC00152 expression in 60 human LAD tissues and paired normal tissues...
January 21, 2017: Molecular Cancer
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