Junyi Hu, Shao-Gang Wang, Yaxin Hou, Zhaohui Chen, Lilong Liu, Ruizhi Li, Nisha Li, Lijie Zhou, Yu Yang, Liping Wang, Liang Wang, Xiong Yang, Yichen Lei, Changqi Deng, Yang Li, Zhiyao Deng, Yuhong Ding, Yingchun Kuang, Zhipeng Yao, Yang Xun, Fan Li, Heng Li, Jia Hu, Zheng Liu, Tao Wang, Yi Hao, Xuanmao Jiao, Wei Guan, Zhen Tao, Shancheng Ren, Ke Chen
Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic and spatial transcriptomic and metabolomic analyses on 100 patients with ccRCC from the Tongji Hospital RCC (TJ-RCC) cohort. Our analysis identifies four ccRCC subtypes including De-clear cell differentiated (DCCD)-ccRCC, a subtype with distinctive metabolic features. DCCD cancer cells are characterized by fewer lipid droplets, reduced metabolic activity, enhanced nutrient uptake capability and a high proliferation rate, leading to poor prognosis...
February 15, 2024: Nature Genetics