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https://www.readbyqxmd.com/read/29337772/salvage-surgery-for-locoregional-failure-in-anal-squamous-cell-carcinoma
#1
Glen R Guerra, Joseph C Kong, Maria-Pia Bernardi, Robert G Ramsay, Wayne A Phillips, Satish K Warrier, A Craig Lynch, Samuel Y Ngan, Alexander G Heriot
BACKGROUND: Anal squamous cell carcinoma is a rare cancer with a high cure rate, making research into the treatment of locoregional failure difficult. OBJECTIVE: The purpose of this study was to examine factors related to local treatment failure and determine the outcomes of patients undergoing local salvage resection. DESIGN: This was a retrospective cohort study. SETTING: This study was conducted at a quaternary referral center...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29336917/changing-practice-evaluation-stage-1-seminoma-outcomes-with-adjuvant-treatment-versus-surveillance-risk-factors-for-recurrence-and-optimizing-follow-up-protocols-experience-from-a-supraregional-center
#2
Helen E J Tyrrell, David N Church, Johnson Joseph, Zoe C Traill, Mark E Sullivan, Mark H Tuthill, Clare L Verrill, Elias P Pintus, Nicola L Dallas, Paul B Rogers, Jacqueline Redgwell, Andrew S Protheroe
BACKGROUND: Stage 1 seminoma is frequently cured by radical orchiectomy; however, the management strategies after this diagnosis vary in terms of the use of adjuvant treatment and the nature of the follow-up protocols. We analyzed stage 1 seminomas treated in the Thames Valley Cancer Network for outcomes to determine whether any factors are predictive of recurrence. We also studied relapses to determine the optimal follow-up schedule and protocol. MATERIALS AND METHODS: Data were obtained from centers within the Thames Valley Cancer Network for a 12-year period from 2004 to 2016...
December 11, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29243581/anticancer-natural-coumarins-as-lead-compounds-for-the-discovery-of-new-drugs
#3
Diana C G A Pinto, Artur M S Silva
Cancer is one of the most serious illnesses of our civilization. The International Agency for Research on Cancer estimated that 14.1 million new cancer cases were diagnosed. Therefore, the cure efficiency of cancer chemotherapy depends not only on how the anticancer drug is delivered to its targets but also on the anticancer drug itself. Among the approved drugs 80% are derived from natural compounds. In this sense, coumarins, natural polyphenols for which anticancer activity has been proved, can be a source or inspire the synthesis of new anticancer agents...
December 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29235195/human-pluripotent-stem-cells-to-produce-cell-based-cancer-immunotherapy
#4
REVIEW
Huang Zhu, Yi-Shin Lai, Ye Li, Robert Blum, Dan Kaufman
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC-derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC-derived T and NK cells have advantages compared to primary immune cells, as they can be precisely engineered to introduce improved anti-tumor activity and produced in essentially unlimited numbers...
December 13, 2017: Stem Cells
https://www.readbyqxmd.com/read/29205560/targeting-cancer-stem-cells-and-signaling-pathways-by-resveratrol-and-pterostilbene
#5
REVIEW
Lingling Zhang, Xiang Wen, Mengmeng Li, Shiming Li, Hui Zhao
In past decades, increasing evidence regarding cancer stem cells (CSCs) may account for carcinogenesis, tumor drug-resistant, and metastasis. CSCs are even considered as the root causes of tumor recurrence and metastases. Targeting CSCs may provide a new clue to cure cancer. Epidemiological and clinical studies have suggested that intake of dietary natural products may bring health benefits including lowering risk of cancer incidence. In this review, we have particularly focused on targeting signaling pathways of CSCs by natural resveratrol and its dimethylated derivative pterostilbene...
December 4, 2017: BioFactors
https://www.readbyqxmd.com/read/29174651/cancer-combination-therapy-of-the-sesquiterpenoid-artesunate-and-the-selective-egfr-tyrosine-kinase-inhibitor-erlotinib
#6
Thomas Efferth
BACKGROUND: The shift from cytotoxic to targeted chemotherapy led to improved treatment outcomes in oncology. Nevertheless, many cancer patients cannot be cured from their disease because of the development of drug resistance and side effects. PURPOSE: There is an ongoing quest for novel compounds, which raised not only the interest in natural products but also in novel combination therapy regimens. STUDY DESIGN: In this review, we report on the inhibition epidermal growth factor receptor (EGFR) by targeted small molecules and their combination with natural products from medicinal plants...
November 10, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29127762/anti-invasive-and-antiproliferative-effects-of-pleurotus-ostreatus-extract-on-acute-leukemia-cell-lines
#7
Alireza Ebrahimi, Amir Atashi, Masoud Soleimani, Maedeh Mashhadikhan, Ahmadreza Barahimi, Amirhossein Maghari
BACKGROUND: Currently, mushrooms have been used in traditional and folk medicines for their therapeutic activities, such as antibiotic, antitumor, anti-inflammatory, anticancer, antileukemic and immunomodulatory actions. This investigation evaluates the anti-invasive, antiproliferative and cytotoxic effects of Pleurotus ostreatus (Pleurotaceae) on leukemia cell lines. METHODS: The proliferation of KG-1 cells was measured by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay after treatment with gradient dilutions of P...
November 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29055715/live-or-let-die-neuroprotective-and-anti-cancer-effects-of-nutraceutical-antioxidants
#8
REVIEW
Xiao-Yuan Mao, Ming-Zhu Jin, Jin-Fei Chen, Qin Li, Hong-Hao Zhou, Wei-Lin Jin
Diet sources are closely involved in the pathogenesis of diverse neuropsychiatric disorders and cancers, in addition to inherited factors. Currently, natural products or nutraceuticals (commonly called medical foods) are increasingly employed for adjunctive therapy of these patients. However, the potential molecular mechanisms of the nutrient efficacy remain elusive. In this review, we summarized the neuroprotective and anti-cancer mechanisms of nutraceuticals. It was concluded that the nutraceuticals exerted neuroprotection and suppressed tumor growth possibly through the differential modulations of redox homeostasis...
October 18, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29027954/marine-sponge-natural-products-with-anticancer-potential-an-updated-review
#9
REVIEW
Cinzia Calcabrini, Elena Catanzaro, Anupam Bishayee, Eleonora Turrini, Carmela Fimognari
Despite the huge investment into research and the significant effort and advances made in the search for new anticancer drugs in recent decades, cancer cure and treatment continue to be a formidable challenge. Many sources, including plants, animals, and minerals, have been explored in the oncological field because of the possibility of identifying novel molecular therapeutics. Marine sponges are a prolific source of secondary metabolites, a number of which showed intriguing tumor chemopreventive and chemotherapeutic properties...
October 13, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28993418/a-genetic-roadmap-of-pancreatic-cancer-still-evolving
#10
REVIEW
Faiyaz Notta, Stephan A Hahn, Francisco X Real
A diagnosis of pancreatic ductal adenocarcinoma (PDA) is often fatal. PDA is widely recognised as one of the 'incurable cancers' because therapies against this tumour type are generally ineffective. The fatal nature of this tumour is due to its aggressive clinical course. Pancreatic cancer commonly presents at the metastatic stage; even in cases where tumours are localised to the pancreas at diagnosis, metastatic seeds have often been invariably been spawned off, frustrating surgical attempts to cure the cancer...
December 2017: Gut
https://www.readbyqxmd.com/read/28962082/protective-effect-of-schisandra-chinensis-bee-pollen-extract-on-liver-and-kidney-injury-induced-by-cisplatin-in-rats
#11
Haibo Huang, Zhenhuang Shen, Qianqian Geng, Zhenhong Wu, Peiying Shi, Xiaoqing Miao
Cisplatin (CP) has been used to cure numerous forms of cancers effectively in clinics, however, it could induce some toxic effects. Bee pollen is a natural compound, produced by honey bees. It is obtained from collected flower pollen and nectar, mixed with bee saliva. Bee pollen produced from Schisandra chinensis plants is described to exert potent antioxidant effects and to be a free radical scavenger. The purpose of this study was to investigate the effects of therapeutic treatment with Schisandra chinensis bee pollen extract (SCBPE) on liver and kidney injury induced by CP...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28941992/nano-delivery-system-targeting-to-cancer-stem-cell-cluster-of-differentiation-biomarkers
#12
REVIEW
Ahad Mokhtarzadeh, Soodabeh Hassanpour, Zahra Farajzadeh Vahid, Maryam Hejazi, Maryam Hashemi, Javad Ranjbari, Maryam Tabarzad, Saeed Noorolyai, Miguel de la Guardia
Cancer stem cells (CSCs) are one of the most important origins of cancer progression and metastasis. CSCs have unique self-renewal properties and diverse cell membrane receptors that induced the resistance to the conventional chemotherapeutic agents. Therefore, the therapeutic removal of CSCs could result in the cancer cure with lack of recurrence and metastasis. In this regard, targeting CSCs in accordance to their specific biomarkers is a talented attitude in cancer therapy. Various CSCs surface biomarkers have been described, which some of them exhibited similarities on different cancer cell types, while the others are cancer specific and have just been reported on one or a few types of cancers...
September 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28935537/affibody-molecules-for-molecular-imaging-and-targeted-drug-delivery-in-the-management-of-breast-cancer
#13
REVIEW
Anindita De, Gowthamarajan Kuppusamy, Veera Venkata Satyanarayana Reddy Karri
Breast cancer is one of the leading reasons for the morbidity and mortality of cancer related death globally. The modern therapies are basically the combination of the breast-preserving surgeries or ablation with or without node biopsy or destroying the carcinoma cells adjuvant with chemotherapy, radiotherapy, hormonal or biological therapies depending upon the nature of the receptor of the cancerous cells, nature of the lymph node, as well as the tendency of the recurrence. For decade's carcinoma management suffered by the limitation of imagining, targeting and penetrability problem associated with management and cure of this deadly disease leads to unwanted chemo-toxicity and side effects...
September 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28933366/the-role-of-the-mapk-signaling-topoisomerase-and-dietary-bioactives-in-controlling-cancer-incidence
#14
REVIEW
Khaled A Selim, Hend Abdelrasoul, Mohamed Aboelmagd, Ahmed M Tawila
Reactive oxygen species (ROS) are common products of mitochondrial oxidative phosphorylation, xenobiotics metabolism and are generated in response to several environmental stress conditions. Some of them play important biochemical roles in cellular signal transduction and gene transcription. On the other hand, ROS are known to be involved in a wide range of human diseases, including cancer. The excessive production of such ROS together with disruption of homeostasis detoxifying mechanisms can mediate a series of cellular oxidative stresses...
April 26, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28875834/argemone-mexicana-a-boon-to-medicinal-and-pharmacological-approaches-in-current-scenario
#15
A Nancy, A Praveena
Nature is God's gift to human beings. Natural products are a source of new chemical diversity and are the choice of today's world. Nature itself gives remedy to all our health problems. The sources of natural product are plants, animals and microorganisms. Among them plant and its products are more reliable for its renewability and therefore, considered as fortunate thing for human welfare. Our traditional system of medicine which has been followed by our ancestors has its own impact on human life. Due to the inadequate knowledge many plant derived products (drugs) has not yet been explored to the society...
August 30, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28871002/trichostatin-a-sensitizes-hepatocellular-carcinoma-cells-to-enhanced-nk-cell-mediated-killing-by-regulating-immune-related-genes
#16
Sangsu Shin, Miok Kim, Seon-Jin Lee, Kang-Seo Park, Chang Hoon Lee
BACKGROUND/AIM: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The ability of HCC to avoid immune detection is considered one of the main factors making it difficult to cure. Abnormal histone deacetylation is thought to be one of the mechanisms for HCC immune escape, making histone deacetylases (HDACs) attractive targets for HCC treatment. Here, we investigated the effect of trichostatin A (TSA), a highly potent HDAC inhibitor, on HCC (HepG2) gene expression and function...
September 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28856217/pcr-based-amplification-of-circulating-rnas-as-prognostic-and-predictive-biomarkers-focus-on-neuroblastoma
#17
Sam C Brownhill, Sue A Burchill
Metastatic disease is a major challenge for cancer cure, haematogenous spread and subsequent growth of tumour cells at distant sites being the cause of most cancer deaths. Molecular characterization and detection of the tumour cells responsible for haematogenous spread may increase understanding of the biology of metastasis, help improve patient management and allow evaluation of novel treatments to prevent and eradicate this disease. The bone marrow is a common site to which tumour cells metastasize, from which they may re-circulate to other organs with a favourable microenvironment for growth...
April 2017: Practical Laboratory Medicine
https://www.readbyqxmd.com/read/28852947/modeling-of-the-metabolic-energy-dissipation-for-restricted-tumor-growth
#18
Ivana Pajic-Lijakovic, Milan Milivojevic
Energy dissipation mostly represents unwanted outcome but in the biochemical processes it may alter the biochemical pathways. However, it is rarely considered in the literature although energy dissipation and its alteration due to the changes in cell microenvironment may improve methods for guiding chemical and biochemical processes in the desired directions. Deeper insight into the changes of metabolic activity of tumor cells exposed to osmotic stress or irradiation may offer the possibility of tumor growth reduction...
October 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28801952/positioning-telling-and-performing-a-male-illness-chronic-prostatitis-chronic-pelvic-pain-syndrome
#19
Nicholas Wood, Annum Qureshi, Fahim Mughal
OBJECTIVES: There is a paucity of illness accounts of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), despite a significant level of prevalence and burden of disease. This qualitative study thus elicited twelve accounts from men suffering with CP/CPPS. METHODS: Narrative analysis was employed, focusing primarily on narrative content. RESULTS: Three major narrative themes were identified: (1) Medical stories: Blame and shame; (2) The Erratic nature of CP/CPPS; and (3) Ongoing struggles for coping and cures and the Search for meaning...
November 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28780353/ultra-microsecond-pulsed-curcumin-for-effective-treatment-of-triple-negative-breast-cancers
#20
Lakshya Mittal, Vishak Raman, Ignacio G Camarillo, Raji Sundararajan
Triple negative breast cancer (TNBC) is difficult to treat due to lack of the three receptors, commonly used for treating breast cancers. Current standard of cure is either ineffective or refractive to many patients. Thus, there is a critical need for alternate, affordable therapies for TNBC cancers. Towards this, electrical pulse-mediated chemotherapy, known as electrochemotherapy is a viable option, because it uses the synergy of electrical pulses and the anticancer properties of chemo drug. Considering the cost and the harsh side effects of various commonly administered chemo drugs, in this study, low cost, yet effective, natural phytochemical curcumin is studied for its anticancer effect on MDA-MB-231, TNBC cells...
September 30, 2017: Biochemical and Biophysical Research Communications
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